CA2382199A1 - Hematology control and system for multi-parameter hematology measurements - Google Patents

Hematology control and system for multi-parameter hematology measurements Download PDF

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Publication number
CA2382199A1
CA2382199A1 CA002382199A CA2382199A CA2382199A1 CA 2382199 A1 CA2382199 A1 CA 2382199A1 CA 002382199 A CA002382199 A CA 002382199A CA 2382199 A CA2382199 A CA 2382199A CA 2382199 A1 CA2382199 A1 CA 2382199A1
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CA
Canada
Prior art keywords
hematology
control
parameter
control compositions
measurements
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002382199A
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French (fr)
Other versions
CA2382199C (en
Inventor
Wayne L. Ryan
John Scholl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Streck Laboratories Inc
Original Assignee
Streck Laboratories, Inc.
Wayne L. Ryan
John Scholl
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27008293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2382199(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/378,608 external-priority patent/US6200500B1/en
Application filed by Streck Laboratories, Inc., Wayne L. Ryan, John Scholl filed Critical Streck Laboratories, Inc.
Publication of CA2382199A1 publication Critical patent/CA2382199A1/en
Application granted granted Critical
Publication of CA2382199C publication Critical patent/CA2382199C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N2001/2893—Preparing calibration standards
    • G01N2015/1014—
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/106664—Blood serum or blood plasma standard or control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2525—Stabilizing or preserving

Abstract

Hematology control compositions and systems used to measure a plurality of parameters in a blood sample are provided.
The hematology control compositions are particularly useful as a control for multi-parameter, automated instrument systems.
The control compositions comprise a reticulocyte component, a white blood cell component, a red blood cell component, and a platelet component. Methods of making and using the control compositions are also provided.
CA002382199A 1999-08-20 2000-08-17 Hematology control and system for multi-parameter hematology measurements Expired - Lifetime CA2382199C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/378,608 US6200500B1 (en) 1999-08-20 1999-08-20 Hematology control and system for multi-parameter hematology measurements
US09/504,816 2000-02-16
US09/378,608 2000-02-16
US09/504,816 US6221668B1 (en) 1999-08-20 2000-02-16 Hematology control and system for multi-parameter hematology measurements
PCT/US2000/022623 WO2001014872A1 (en) 1999-08-20 2000-08-17 Hematology control and system for multi-parameter hematology measurements

Publications (2)

Publication Number Publication Date
CA2382199A1 true CA2382199A1 (en) 2001-03-01
CA2382199C CA2382199C (en) 2007-07-03

Family

ID=27008293

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002382199A Expired - Lifetime CA2382199C (en) 1999-08-20 2000-08-17 Hematology control and system for multi-parameter hematology measurements

Country Status (8)

Country Link
US (4) US6221668B1 (en)
EP (1) EP1212613B1 (en)
JP (2) JP2003507740A (en)
AT (1) ATE363657T1 (en)
AU (1) AU6645900A (en)
CA (1) CA2382199C (en)
DE (1) DE60035053T2 (en)
WO (1) WO2001014872A1 (en)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509192B1 (en) * 1992-02-24 2003-01-21 Coulter International Corp. Quality control method
US6444471B1 (en) 1999-10-18 2002-09-03 Research & Diagnostic Systems, Inc. Reticulocyte containing complete blood control
US6531321B1 (en) * 2000-09-15 2003-03-11 Streck Laboratories, Inc. Blood control and system for erythrocyte sedimentation measurement
US6448085B1 (en) * 2001-04-13 2002-09-10 Sysmex Corporation Quality control material and calibrator for nucleated red blood cell tested on hematology analyzer
US6759246B1 (en) * 2001-11-30 2004-07-06 Research & Diagnostic Systems, Inc. Hematology control composition including lymphocyte analogs and method for preparation and use
US6653137B2 (en) 2001-12-03 2003-11-25 Streck Laboratories Inc. Hematology reference control
WO2004003568A1 (en) * 2001-12-03 2004-01-08 Streck Laboratories, Inc. Hematology reference control
US6723563B2 (en) 2001-12-03 2004-04-20 Streck Laboratories Inc. Hematology reference control
US7098189B2 (en) 2002-12-16 2006-08-29 Kimberly-Clark Worldwide, Inc. Wound and skin care compositions
US7267980B1 (en) 2003-04-04 2007-09-11 Research & Diagnostic Systems, Inc. Stabilizing solution for cells and tissues
WO2005036164A1 (en) * 2003-10-02 2005-04-21 Beckman Coulter, Inc. Reference control for optical measurement of nucleated red blood cells of a blood sample
US7198953B2 (en) * 2003-10-12 2007-04-03 Beckman Coulter, Inc. Method of using a reference control composition for measurement of nucleated red blood cells
EP1682865B1 (en) * 2003-10-12 2018-08-15 Beckman Coulter, Inc. Method of using a reference control composition for measurement of nucleated red blood cells
US7195919B2 (en) * 2003-12-19 2007-03-27 Beckman Coulter, Inc. Hematology controls for reticulocytes and nucleated red blood cells
WO2005100979A1 (en) * 2004-04-07 2005-10-27 Beckman Coulter, Inc. Reference control containing a nucleated red blood cell component
US7109036B2 (en) * 2004-05-13 2006-09-19 Beckman Coulter, Inc. Hematology reference control containing an immature granulocyte component
US7485666B2 (en) 2004-06-17 2009-02-03 Kimberly-Clark Worldwide, Inc. Vaginal health products
US7244618B2 (en) * 2004-09-01 2007-07-17 Maine Standards Company, Llc Stable lipid standards
US7531357B2 (en) * 2005-04-04 2009-05-12 Bio-Rad Laboratories, Inc. Preparation of platelet analogs
US7354767B2 (en) * 2006-03-16 2008-04-08 Beckman Coulter, Inc. Reference control composition containing a nucleated red blood cell component made of non-nucleated blood cells
US7482161B2 (en) * 2006-07-17 2009-01-27 Bio-Rad Laboratories, Inc. Preparation of a red blood cell component for a hematology control
WO2008061073A2 (en) 2006-11-14 2008-05-22 Beckman Coulter, Inc. Hematology linearity control composition system and method of use
US7618821B2 (en) * 2007-04-13 2009-11-17 Streck, Inc. Simulated blood components and methods
CN101311724B (en) * 2007-05-24 2014-11-12 深圳迈瑞生物医疗电子股份有限公司 Single group leucocyte emulation ion, calibrator comprising same and its preparation method
CN101311725B (en) 2007-05-25 2014-03-26 深圳迈瑞生物医疗电子股份有限公司 WBC differential count quality control matter and method for making same
CN101561443B (en) * 2008-04-15 2013-08-21 深圳迈瑞生物医疗电子股份有限公司 Five-classification leucocyte simulacrum particle, method for preparing same, and quality control substance and calibration substance containing same
GB0808413D0 (en) * 2008-05-09 2008-06-18 Univ Nottingham Stabilisation of blood cell conjugates
DE102008026665A1 (en) * 2008-06-04 2009-12-17 Dr. Lerche Kg Process for and material of a molding standard
US20100086962A1 (en) 2008-10-08 2010-04-08 Streck, Inc. Hematology controls and methods
WO2010078194A1 (en) * 2008-12-30 2010-07-08 Streck, Inc. Method for screening blood using a preservative that may be in a substantially solid state form
US8114580B2 (en) * 2009-01-13 2012-02-14 Bio-Rad Laboratories, Inc. Simulation of normal fresh blood platelets for reference control
CN101881778B (en) * 2009-05-06 2014-01-29 深圳迈瑞生物医疗电子股份有限公司 Reticulocyte mimics and preparation method thereof
US9504641B2 (en) * 2011-09-10 2016-11-29 Richard C. K. Yen Therapy to reduce extravasation damage
US10603287B2 (en) 2016-07-20 2020-03-31 Ptlnv, Llc, Series Three (3) Albumin nanosphere preparations to control bleeding from surgical operations
US11260110B2 (en) 2009-11-18 2022-03-01 Ptlnv, Llc, Series Four (4) Nanoparticles for the therapeutic treatment of radiation-induced skin ulcers
CN102109430B (en) * 2009-12-25 2013-11-06 深圳迈瑞生物医疗电子股份有限公司 Nucleated red blood cell simulation particle and blood quality control substance and preparation methods and application thereof
US9091677B2 (en) 2010-08-09 2015-07-28 Beckman Coulter, Inc. Isotonic buffered composition and method that enables counting of cells
US9040255B2 (en) 2010-09-23 2015-05-26 Biocept, Inc. Use of diazolidinyl urea for anti-clumping of biological samples
US8551784B2 (en) 2010-11-17 2013-10-08 Streck, Inc. Cis di-ahl modified controls for glycated hemoglobin S-A1c derived from healthy blood cells
US8546144B2 (en) 2010-11-17 2013-10-01 Streck, Inc. Method of preparing controls for glycated hemoglobin S-A1c derived from healthy blood cells
US20120308985A1 (en) * 2011-04-21 2012-12-06 Streck, Inc. Immature Reticulocyte Fraction Reference Control and Related Methods
JP6117181B2 (en) * 2011-04-28 2017-04-19 ベックマン コールター， インコーポレイテッド Hematology control composition with long-term stability
JP6300352B2 (en) * 2014-03-31 2018-03-28 シーシーアイ株式会社 Standard substance composition for measuring neutral fat concentration and method for producing the same
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US11582967B2 (en) * 2015-08-13 2023-02-21 Fenwal, Inc. Medium and methods for the storage of red blood cells
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
WO2018022991A1 (en) 2016-07-29 2018-02-01 Streck, Inc. Suspension composition for hematology analysis control
WO2018187348A1 (en) * 2017-04-03 2018-10-11 Immucor, Inc. Red cell diluent with edta and methods for making and using the same
CN109459372B (en) * 2018-10-29 2021-03-26 迪瑞医疗科技股份有限公司 Nucleated erythrocyte simulated particle and preparation method and application thereof
CN111413176B (en) * 2020-05-09 2023-05-16 河北艾驰生物科技有限公司 Erythrocyte and leucocyte quality control substance for urine component analysis and preparation method thereof
JP2023525338A (en) * 2020-05-13 2023-06-15 ベクトン・ディキンソン・アンド・カンパニー Blood-based controls for composite panels
EP4208021A1 (en) * 2020-09-03 2023-07-12 Bio-Rad Laboratories, Inc. Preparation of nucleated rbc (nrbc) analogs for use as reference hematology controls in automated hematology analyzers
JP7262558B1 (en) 2021-11-30 2023-04-21 シスメックス株式会社 Accuracy control sample measurement method and sample analyzer

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL30925A (en) 1967-11-08 1972-12-29 Torlontano G Preparation of blood corpuscles suspensions
US3574137A (en) 1969-02-25 1971-04-06 Pfizer Multiple-analysis hematology control comprising human red blood cells and fowl red blood cells in an anticoagulant containing human serologically compatible plasma medium
US3558522A (en) 1969-03-05 1971-01-26 Baxter Laboratories Inc Hematology control standard comprising washed red blood cells and synthetic latex particles
US3640896A (en) 1970-04-13 1972-02-08 Pfizer Process for stabilizing fowl red blood cells
US3873467A (en) 1974-02-01 1975-03-25 United Medical Lab Inc Hematologic reference control
US4179398A (en) 1977-03-21 1979-12-18 ICN Medical Laboratories, Inc. Platelet control composition
US4160644A (en) 1977-06-13 1979-07-10 Streck Laboratories, Inc. Platelet reference control and method of preparation
US4198206A (en) 1977-06-13 1980-04-15 Ryan Wayne L Method for preparing a platelet reference control
US4099917A (en) 1977-07-21 1978-07-11 Technicon Instruments Corporation Process for preparing a cell suspension from blood for discrimination of white blood cells and platelets from other blood particles
US4219440A (en) 1979-06-06 1980-08-26 Coulter Electronics, Inc. Multiple analysis hematology reference control reagent and method of making the same
US4324687A (en) 1979-02-15 1982-04-13 Louderback Allan Lee Blood biochemistry control standard
US4358394A (en) 1979-05-07 1982-11-09 Coulter Electronics, Inc. Process for preparing whole blood reference controls having long term stability
US4299726A (en) 1979-05-07 1981-11-10 Coulter Electronics, Inc. Process for preparing whole blood reference controls having long term stability, preconditioning diluent and media therefor
US4264470A (en) 1979-05-07 1981-04-28 Coulter Electronics, Inc. Selecting goat erythrocytes to simulate human platelets in hematologic reference controls
US4324686A (en) 1979-06-11 1982-04-13 R & D Systems, Inc. Hematology control composition and methods for its use
US4390632A (en) 1980-07-14 1983-06-28 Coulter Electronics, Inc. Stabilization process for biological cells and stabilized compositions thereof
US4336029A (en) * 1980-08-15 1982-06-22 Ortho Diagnostic Systems Inc. Method and reagents for quantitative determination of reticulocytes and platelets in whole blood
US4389490A (en) 1981-05-29 1983-06-21 Coulter Electronics, Inc. Method of stabilizing platelets for determining multiple platelet parameters in reference control and calibrator compositions; and diluents thereof
US4425334A (en) 1982-04-02 1984-01-10 The Regents Of The University Of California Functional oxygen transport system
US4436821A (en) 1982-04-12 1984-03-13 Streck Laboratories, Inc. Simulated human platelets from red blood cells
US4704364A (en) 1984-05-18 1987-11-03 Coulter Electronics, Inc. Hematology control compositions for three populations of leukocytes; and methods for their preparation and use in whole blood control systems
US4751179A (en) 1984-05-31 1988-06-14 Coulter Electronics, Inc. Method and reagents for differential determination of four populations of leukocytes in blood
US4711852A (en) 1984-11-05 1987-12-08 Akzo N.V. Control for blood gas analyzers and hemoglobin analysis
US4745071A (en) 1985-09-05 1988-05-17 Sequoia-Turner Corporation Method for the volumetric differentiation of blood cells types
US4698312A (en) 1986-07-28 1987-10-06 Fisher Scientific Company Stabilizing blood cells with aromatic polyaldehyde for use in hematology controls and calibrators
US4777139A (en) 1987-06-25 1988-10-11 Fisher Scientific Company Hematology control or calibrator with red cell components of enhanced stability
GB8717860D0 (en) 1987-07-28 1987-09-03 Enviroguard Inc Formation of soluble silicates
JP2619911B2 (en) * 1988-04-08 1997-06-11 東亜医用電子株式会社 Standard blood for reticulocyte analyzer
US5008201A (en) 1990-05-24 1991-04-16 Streck Laboratories, Inc. Simulated human platelets from red blood cells
IE76732B1 (en) * 1990-08-07 1997-11-05 Becton Dickinson Co One step test for absolute counts
JPH04326061A (en) * 1991-04-26 1992-11-16 Hitachi Ltd Blood analyser
US5459073A (en) 1991-05-08 1995-10-17 Streck Laboratories, Inc. Method and composition for preserving antigens and process for utilizing cytological material produced by same
US5460797A (en) 1991-05-08 1995-10-24 Streck Laboratories, Inc. Method for fixing tissues and cells for analysis using oxazolidine compounds
US5262327A (en) 1991-05-09 1993-11-16 Streck Laboratories, Inc. White blood cell hematology control
US5270208A (en) 1991-05-09 1993-12-14 Streck Laboratories, Inc. White blood cell hematology control
CA2129834A1 (en) 1992-02-24 1993-08-25 Michael N. Elliott Suspension media for hematological composition and method for its use
WO1993017330A1 (en) 1992-02-24 1993-09-02 Coulter Corporation Hematology control composition for leukocyte analogs; and methods for their preparation and use
WO1993018397A1 (en) 1992-03-02 1993-09-16 Streck Laboratories, Inc. Reference control for use with manual and flow cytometric reticulocyte counting devices
DE69432410T2 (en) 1993-05-14 2004-03-04 Coulter International Corp., Miami RETICULOYCYTE DETERMINATION METHOD AND DEVICE USING LIGHT SCATTERING TECHNIQUES
US5656499A (en) * 1994-08-01 1997-08-12 Abbott Laboratories Method for performing automated hematology and cytometry analysis
WO1996012181A1 (en) 1994-10-12 1996-04-25 Research & Diagnostics Systems, Inc. Reticulocyte assay control
US5492883A (en) 1994-11-21 1996-02-20 Corning Incorporated Molecular sieve structures using aqueous emulsions
EP0771420A1 (en) * 1995-04-28 1997-05-07 Coulter International Corp. Quality control method of hematology instruments
US5858790A (en) 1996-06-26 1999-01-12 Abbott Laboratories Hematology reference control and method of preparation
US5705391A (en) 1996-08-14 1998-01-06 Associated Universities, Inc. Modified acyl-ACP desaturase
US5874311A (en) * 1997-11-21 1999-02-23 Coulter International Corp. Method for differentiation of reticulocytes in blood

Also Published As

Publication number Publication date
US20020019053A1 (en) 2002-02-14
CA2382199C (en) 2007-07-03
US6399388B1 (en) 2002-06-04
AU6645900A (en) 2001-03-19
US20020022271A1 (en) 2002-02-21
EP1212613B1 (en) 2007-05-30
DE60035053D1 (en) 2007-07-12
EP1212613A4 (en) 2005-09-21
US6403377B1 (en) 2002-06-11
ATE363657T1 (en) 2007-06-15
US6406915B2 (en) 2002-06-18
WO2001014872A1 (en) 2001-03-01
JP2005121661A (en) 2005-05-12
EP1212613A1 (en) 2002-06-12
US6221668B1 (en) 2001-04-24
DE60035053T2 (en) 2008-01-31
JP2003507740A (en) 2003-02-25

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