CA2382442A1 - Pore structures for reduced pressure aerosolization - Google Patents

Pore structures for reduced pressure aerosolization Download PDF

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Publication number
CA2382442A1
CA2382442A1 CA002382442A CA2382442A CA2382442A1 CA 2382442 A1 CA2382442 A1 CA 2382442A1 CA 002382442 A CA002382442 A CA 002382442A CA 2382442 A CA2382442 A CA 2382442A CA 2382442 A1 CA2382442 A1 CA 2382442A1
Authority
CA
Canada
Prior art keywords
pores
increased
structures
aerosolization
pore structures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002382442A
Other languages
French (fr)
Other versions
CA2382442C (en
Inventor
Rajesh S. Patel
Sudarsan Srinivasan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aradigm Corp
Original Assignee
Aradigm Corporation
Rajesh S. Patel
Sudarsan Srinivasan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/432,890 external-priority patent/US6354516B1/en
Application filed by Aradigm Corporation, Rajesh S. Patel, Sudarsan Srinivasan filed Critical Aradigm Corporation
Publication of CA2382442A1 publication Critical patent/CA2382442A1/en
Application granted granted Critical
Publication of CA2382442C publication Critical patent/CA2382442C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
    • A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled

Abstract

A nozzle (38) comprising a thin, flexible substantially planar polymeric film (46) having a plurality of pores (302) with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps (h1, h2), in which the thickness of the membrane is reduced in stepwise fashion, or the pores can be tapered.
Nozzles formed comprising pores having such structures permit aerosol generation at lower extrusion pressures, thereby allowing for decreased weight of aerosolization devices, increased efficiency, increased portability and increased battery life. The pore structures (302) also allow for the use of thicker, more easily processed polymeric films in manufacturing while having a thinner, more efficient aerosolization area. The use of decreased extrusion pressures also results in increased uniformity in aerosol generation and improved reliability of other components.
CA002382442A 1999-09-15 2000-09-11 Pore structures for reduced pressure aerosolization Expired - Fee Related CA2382442C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15419899P 1999-09-15 1999-09-15
US60/154,198 1999-09-15
US09/432,890 US6354516B1 (en) 1999-11-02 1999-11-02 Pore structures for reduced pressure aerosolization
US09/432,890 1999-11-02
PCT/US2000/024887 WO2001019528A1 (en) 1999-09-15 2000-09-11 Pore structures for reduced pressure aerosolization

Publications (2)

Publication Number Publication Date
CA2382442A1 true CA2382442A1 (en) 2001-03-22
CA2382442C CA2382442C (en) 2009-07-07

Family

ID=26851240

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002382442A Expired - Fee Related CA2382442C (en) 1999-09-15 2000-09-11 Pore structures for reduced pressure aerosolization

Country Status (9)

Country Link
US (2) US6689986B2 (en)
EP (1) EP1222033B1 (en)
JP (1) JP2003509142A (en)
AT (1) ATE345875T1 (en)
AU (1) AU781452B2 (en)
CA (1) CA2382442C (en)
DE (1) DE60032003T2 (en)
ES (1) ES2275545T3 (en)
WO (1) WO2001019528A1 (en)

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US6354516B1 (en) 1999-11-02 2002-03-12 Aradigm Corporation Pore structures for reduced pressure aerosolization
CA2441366A1 (en) * 2001-03-24 2002-10-03 Aviva Biosciences Corporation Biochips including ion transport detecting structures and methods of use
US20060029955A1 (en) * 2001-03-24 2006-02-09 Antonio Guia High-density ion transport measurement biochip devices and methods
US20050196746A1 (en) * 2001-03-24 2005-09-08 Jia Xu High-density ion transport measurement biochip devices and methods
US20050009004A1 (en) * 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US7244703B2 (en) * 2001-06-22 2007-07-17 Bentley Pharmaceuticals, Inc. Pharmaceutical compositions and methods for peptide treatment
ATE510174T1 (en) 2003-05-21 2011-06-15 Alexza Pharmaceuticals Inc IMPACT LIT INDEPENDENT HEATING UNIT
AU2004296784B2 (en) 2003-12-08 2010-12-02 Cpex Pharmaceuticals, Inc. Pharmaceutical compositions and methods for insulin treatment
US20050281739A1 (en) * 2004-06-16 2005-12-22 Glen Gong Imaging damaged lung tissue using compositions
US7553810B2 (en) * 2004-06-16 2009-06-30 Pneumrx, Inc. Lung volume reduction using glue composition
US7678767B2 (en) 2004-06-16 2010-03-16 Pneumrx, Inc. Glue compositions for lung volume reduction
US7608579B2 (en) * 2004-06-16 2009-10-27 Pneumrx, Inc. Lung volume reduction using glue compositions
US20050281799A1 (en) 2004-06-16 2005-12-22 Glen Gong Targeting damaged lung tissue using compositions
US20050281798A1 (en) * 2004-06-16 2005-12-22 Glen Gong Targeting sites of damaged lung tissue using composition
EP1781182B1 (en) 2004-07-08 2019-11-13 PneumRx, Inc. Pleural effusion treatment device
WO2006031775A2 (en) 2004-09-13 2006-03-23 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
US20070148567A1 (en) * 2005-12-09 2007-06-28 Joerg Ferber Method and apparatus for laser-drilling an inkjet orifice in a substrate
US8337814B2 (en) * 2005-12-15 2012-12-25 Topical Sinus Therapeutics, Inc. Treatment of active infections, sinusitis, rhinitis, and related neurological disorders and related compositions
US7958887B2 (en) 2006-03-10 2011-06-14 Aradigm Corporation Nozzle pore configuration for intrapulmonary delivery of aerosolized formulations
JP2010504410A (en) * 2006-09-20 2010-02-12 ヌームアールエックス， インコーポレイテッド Tissue adhesive composition and method thereof
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
US9034007B2 (en) * 2007-09-21 2015-05-19 Insera Therapeutics, Inc. Distal embolic protection devices with a variable thickness microguidewire and methods for their use
US9414968B2 (en) * 2008-09-05 2016-08-16 Smith & Nephew, Inc. Three-dimensional porous film contact layer with improved wound healing
TWI506070B (en) * 2009-12-14 2015-11-01 3M Innovative Properties Co Microperforated polymeric film and methods of making and using the same
AU2013273670B2 (en) * 2009-12-14 2015-11-05 3M Innovative Properties Company Microperforated polymeric film and methods of making and using the same
BR112013031464A2 (en) 2011-06-07 2016-12-06 Smith & Nephew Wound Contact Methods and Limbs
US8679150B1 (en) 2013-03-15 2014-03-25 Insera Therapeutics, Inc. Shape-set textile structure based mechanical thrombectomy methods
US8715314B1 (en) 2013-03-15 2014-05-06 Insera Therapeutics, Inc. Vascular treatment measurement methods
US8715315B1 (en) 2013-03-15 2014-05-06 Insera Therapeutics, Inc. Vascular treatment systems
WO2014150288A2 (en) 2013-03-15 2014-09-25 Insera Therapeutics, Inc. Vascular treatment devices and methods
US9168476B2 (en) 2013-10-11 2015-10-27 3M Innovative Properties Company Air filter comprising a microperforated film, and method of using
TR201906899T4 (en) * 2014-07-11 2019-05-21 Philip Morris Products Sa Aerosol-forming cartridge with protective foil.
CN108697423A (en) 2016-02-16 2018-10-23 伊瑟拉医疗公司 The part flow arrangement of suction unit and anchoring
CN110520206B (en) * 2016-09-13 2022-03-18 海世欧申有限责任公司 Microfluidic filter device

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US4894115A (en) 1989-02-14 1990-01-16 General Electric Company Laser beam scanning method for forming via holes in polymer materials
US4959119A (en) * 1989-11-29 1990-09-25 E. I. Du Pont De Nemours And Company Method for forming through holes in a polyimide substrate
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GB9109064D0 (en) * 1991-04-26 1991-06-12 Dunne Miller Weston Ltd Dispensing device
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US5709202A (en) 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
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JP3748890B2 (en) 1994-10-28 2006-02-22 アラダイム コーポレーション Disposable container, disposable package, drug delivery device, and method for producing aerosol for use in aerosolized spray of respiratory medication
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Also Published As

Publication number Publication date
AU7369000A (en) 2001-04-17
AU781452B2 (en) 2005-05-26
EP1222033A1 (en) 2002-07-17
WO2001019528A1 (en) 2001-03-22
EP1222033B1 (en) 2006-11-22
ATE345875T1 (en) 2006-12-15
US6689986B2 (en) 2004-02-10
US20020088781A1 (en) 2002-07-11
CA2382442C (en) 2009-07-07
DE60032003D1 (en) 2007-01-04
JP2003509142A (en) 2003-03-11
ES2275545T3 (en) 2007-06-16
US20040124185A1 (en) 2004-07-01
DE60032003T2 (en) 2007-06-06
US6855909B2 (en) 2005-02-15
EP1222033A4 (en) 2003-03-19

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