CA2385342A1 - Improved electrochemical sensor - Google Patents

Improved electrochemical sensor Download PDF

Info

Publication number
CA2385342A1
CA2385342A1 CA002385342A CA2385342A CA2385342A1 CA 2385342 A1 CA2385342 A1 CA 2385342A1 CA 002385342 A CA002385342 A CA 002385342A CA 2385342 A CA2385342 A CA 2385342A CA 2385342 A1 CA2385342 A1 CA 2385342A1
Authority
CA
Canada
Prior art keywords
base
test sample
fluid test
electrochemical sensor
sensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002385342A
Other languages
French (fr)
Other versions
CA2385342C (en
Inventor
Yingping Deng
Sherry J. Jamison
Andrew J. Edelbrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Healthcare LLC
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of CA2385342A1 publication Critical patent/CA2385342A1/en
Application granted granted Critical
Publication of CA2385342C publication Critical patent/CA2385342C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted

Abstract

Disclosed is an improved electrochemical sensor for the detection of an analyte in a fluid test sample. The electro-chemical sensor is of the type in which the fluid test sample is drawn into a capillary space and the improvement to the sensor involves an arrangement where a portion of the sensor's counter electrode is placed on the edge of the capillary space in a relationship to the sensor's working electrode such that if the capillary space is not completely filled there will be generated only a very weak current. When the sensor is con-nected to a properly programmed current detector, the weak current caused by the underfilling of the capillary space will be detected as an error and will notify the user of the sensor that the test should not be continued.

Claims (12)

1. In an electrochemical sensor for detecting the concentra-tion of analyte in a fluid test sample comprising (1) a non-conductive base which provides a flow path for the fluid test sample which base has a front edge as well as a counter elec-trode and a working electrode on its upper surface which are in electrical communication with a detector of electrical cur-rent; (2) a reaction layer on at least the surface of the working electrode comprising an enzyme which reacts with the analyte to produce electrons which are transferred to the working electrode; and (3) a cover which when mated with the base forms a capillary space with an opening for the introduc-tion of fluid test sample thereto which space contains the flow path for the fluid test sample in which the counter and working electrodes are situated so that the major portion of the counter electrode is located downstream of the opening from the working electrode with a sub-element of the reference electrode being upstream from the working electrode so that when electrochemical communication between only the sub-element of the counter electrode and the working electrode takes place, there is insufficient flow of electrical current through the detector to constitute a valid test for the con-centration of analyte in the fluid test sample and the detec-tor is pre-programmed to emit an error signal in the event of such insufficient flow of electrical current, the improvement which comprises placing the sub-element of the counter elec-trode on the upper surface of the base so that it is flush with the front edge of the base.
2. The electrochemical sensor of Claim 1 which is connected to a current detector which is programmed to give an error signal when the current it receives is below a predetermined level.
3. The electrochemical sensor of Claim 1 wherein there is a dielectric layer over the working and counter electrode having openings to expose these electrodes to a reaction layer on top of the dielectric layer and the area of the sub-element of the counter electrode which is exposed is 2% to 7% of the area of the working electrode which is exposed.
4. The electrochemical sensor of Claim 3 wherein the sub-element of the counter electrode is not in contact with the reaction layer.
5. The electrochemical sensor of Claim 1 wherein the sub-element is physically disconnected from the rest of the coun-ter electrode and is provided with its own connector from con-tact with a current detector.
6. The electrochemical sensor of Claim 1 wherein the cover has a concave portion; so that the concave portion forms the capillary space when the cover is mated with the base.
7. The electrochemical sensor of Claim 1 which has a spacer element with a U shaped indentation so that the U shaped in-dentation forms the capillary space when it is inserted be-tween the cover and the base.
8. A method for the electrochemical determination of an ana-lyte in a fluid test sample which comprises connecting the electrochemical sensor of Claim 1 to a current detector which is programmed to detect a current which is weaker than a pre-determined current level and introducing the fluid test sample into the capillary space of the sensor.
9. The method of Claim 8 wherein the current detector is programmed to provide an error signal when the current is weaker than the predetermined current level.
10. The method of Claim 8 wherein the fluid test sample is blood and the analyte is glucose.
11. A method for the production of a base member for an elec-trochemical sensor for detecting the concentration of an ana-lyte in a fluid test sample which comprises the steps of:

a) providing an insulating base material in the form of a sheet from which a plurality of bases for the sen-sor can be punched out to form a base having a front edge;
b) screen printing an electrically conductive pattern on to the insulating base material;

c) screen printing a working electrode and a counter electrode onto the conductive pattern so that the main portion of the counter electrode lies further from the front edge of the base than the working electrode and a sub-element of the counter electrode overlaps the base's front edge; and d) punching the base from the sheet of insulating base material in a pattern such that the sub-element of the counter electrode is flush with the front edge of the base.
12. A method for the production of an electrochemical sensor which comprises the steps of:

a) providing the base member prepared as in Claim 11;
b) screen printing a dielectric layer onto the working and control electrodes in a pattern which leaves predetermined portions of these electrodes exposed;

c) screen printing a reaction layer over the dielectric layer; and d) applying a cover member to the base member to form a capillary space into which the fluid test sample can flow;
wherein steps a, b, c and d are carried out before the base member is punched from the sheet of insulating base member ma-terial.
CA2385342A 2001-05-21 2002-05-08 Improved electrochemical sensor Expired - Fee Related CA2385342C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29200501P 2001-05-21 2001-05-21
US60/292,005 2001-05-21

Publications (2)

Publication Number Publication Date
CA2385342A1 true CA2385342A1 (en) 2002-11-21
CA2385342C CA2385342C (en) 2010-12-21

Family

ID=23122780

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2385342A Expired - Fee Related CA2385342C (en) 2001-05-21 2002-05-08 Improved electrochemical sensor

Country Status (7)

Country Link
US (2) US20020175075A1 (en)
EP (1) EP1262769B1 (en)
JP (1) JP3612307B2 (en)
AT (1) ATE493644T1 (en)
AU (1) AU784254B2 (en)
CA (1) CA2385342C (en)
DE (1) DE60238733D1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114544733A (en) * 2020-11-25 2022-05-27 五鼎生物技术股份有限公司 Biochemical test piece

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
CN1598564B (en) * 1997-12-22 2010-04-21 罗赫诊断手术公司 Meter
US8071384B2 (en) 1997-12-22 2011-12-06 Roche Diagnostics Operations, Inc. Control and calibration solutions and methods for their use
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6841052B2 (en) 1999-08-02 2005-01-11 Bayer Corporation Electrochemical-sensor design
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
AU2002312521A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
US7033371B2 (en) 2001-06-12 2006-04-25 Pelikan Technologies, Inc. Electric lancet actuator
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
WO2002100461A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
EP1404233B1 (en) 2001-06-12 2009-12-02 Pelikan Technologies Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
WO2002100254A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
CA2419213C (en) * 2002-03-07 2011-06-21 Bayer Healthcare Llc Improved electrical sensor
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7132041B2 (en) * 2003-02-11 2006-11-07 Bayer Healthcare Llc Methods of determining the concentration of an analyte in a fluid test sample
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US8058077B2 (en) 2003-06-20 2011-11-15 Roche Diagnostics Operations, Inc. Method for coding information on a biosensor test strip
US7597793B2 (en) * 2003-06-20 2009-10-06 Roche Operations Ltd. System and method for analyte measurement employing maximum dosing time delay
US7718439B2 (en) 2003-06-20 2010-05-18 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7604721B2 (en) * 2003-06-20 2009-10-20 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7645421B2 (en) 2003-06-20 2010-01-12 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7645373B2 (en) 2003-06-20 2010-01-12 Roche Diagnostic Operations, Inc. System and method for coding information on a biosensor test strip
US8148164B2 (en) 2003-06-20 2012-04-03 Roche Diagnostics Operations, Inc. System and method for determining the concentration of an analyte in a sample fluid
US7452457B2 (en) * 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
US8206565B2 (en) * 2003-06-20 2012-06-26 Roche Diagnostics Operation, Inc. System and method for coding information on a biosensor test strip
GB2404739B (en) * 2003-08-05 2006-04-12 E2V Tech Uk Ltd Sensor
AU2003261594A1 (en) * 2003-09-03 2005-03-16 Jianyuan Chen An novel test strip, the method for its manufacture and the use thereof
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US20050067277A1 (en) * 2003-09-30 2005-03-31 Pierce Robin D. Low volume electrochemical biosensor
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc Method and apparatus for a variable user interface
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
RU2371707C2 (en) 2004-02-06 2009-10-27 БАЙЕР ХЕЛТКЭР ЭлЭлСи Electrochemical biosensor
EP1751546A2 (en) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Printable hydrogel for biosensors
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc Method and apparatus for a fluid sampling device
JP4805259B2 (en) 2004-06-17 2011-11-02 バイエル・ヘルスケア・エルエルシー Detection of incomplete filling of biosensor
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
DE102004033317A1 (en) * 2004-07-09 2006-02-09 Roche Diagnostics Gmbh Analytical test element
CA2973124C (en) 2004-10-12 2020-01-07 Ascensia Diabetes Care Holdings Ag Concentration determination in a diffusion barrier layer
GB2420180A (en) * 2004-11-11 2006-05-17 Sensor Tech Ltd Method of electrochemical analysis of an analyte
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
GB0514728D0 (en) * 2005-07-19 2005-08-24 Hypoguard Ltd Biosensor and method of manufacture
CA2609720C (en) * 2005-07-20 2015-06-30 Bayer Healthcare Llc Gated amperometry
US7966859B2 (en) * 2006-05-03 2011-06-28 Bayer Healthcare Llc Underfill detection system for a biosensor
US7993512B2 (en) 2006-07-11 2011-08-09 Bayer Healthcare, Llc Electrochemical test sensor
KR101096898B1 (en) * 2006-07-26 2011-12-22 파나소닉 주식회사 Biosensor measuring system, and measuring method
JP5056755B2 (en) * 2006-07-26 2012-10-24 パナソニック株式会社 Biosensor measurement system and abnormal waveform detection method in biosensor
US7802467B2 (en) * 2006-12-22 2010-09-28 Abbott Diabetes Care Inc. Analyte sensors and methods of use
US8163146B2 (en) * 2007-10-12 2012-04-24 Abbott Diabetes Care Inc. Mediator stabilized reagent compositions for use in biosensor electrodes
WO2009076271A2 (en) * 2007-12-10 2009-06-18 Bayer Healthcare Llc Wear-resistant electrochemical test sensor and method of forming the same
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
US8280474B2 (en) * 2008-06-02 2012-10-02 Abbott Diabetes Care Inc. Reference electrodes having an extended lifetime for use in long term amperometric sensors
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US9378443B2 (en) 2009-05-14 2016-06-28 Ascensia Diabetes Care Holding Ag Calibration coded sensors and apparatus, systems and methods for reading same
US8357276B2 (en) 2009-08-31 2013-01-22 Abbott Diabetes Care Inc. Small volume test strips with large sample fill ports, supported test strips, and methods of making and using same
MX2012005412A (en) 2009-11-10 2012-08-15 Bayer Healthcare Llc Underfill recognition system for a biosensor.
KR101929057B1 (en) * 2010-03-22 2018-12-13 바이엘 헬쓰케어 엘엘씨 Residual compensation for a biosensor
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
CA3047242A1 (en) 2010-06-07 2011-12-15 Ascensia Diabetes Care Holdings Ag Underfill management system for a biosensor
WO2012064648A1 (en) 2010-11-12 2012-05-18 Bayer Healthcare Llc Auto-coded analyte sensors and apparatus, systems, and methods for detecting same
JP5819183B2 (en) 2011-02-03 2015-11-18 アークレイ株式会社 Analysis device, sensor inspection device, inspection method, and inspection program
WO2012114706A1 (en) 2011-02-23 2012-08-30 パナソニック株式会社 Biological sample measuring device
JP5953301B2 (en) 2011-06-16 2016-07-20 パナソニックヘルスケアホールディングス株式会社 Sensor and sensor system including the same
US9775806B2 (en) 2011-09-21 2017-10-03 Ascensia Diabetes Care Holdings Ag Analysis compensation including segmented signals
KR101367262B1 (en) * 2011-11-11 2014-02-26 주식회사 아이센스 Blood Glucose Sensor and sensing error detecting method using thereof
US9097659B2 (en) * 2013-03-14 2015-08-04 Bayer Healthcare Llc Maintaining electrode function during manufacture with a protective layer
GB201321430D0 (en) 2013-12-04 2014-01-15 Spd Swiss Prec Diagnostics Gmbh Assay device

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68924026T3 (en) * 1988-03-31 2008-01-10 Matsushita Electric Industrial Co., Ltd., Kadoma BIOSENSOR AND ITS MANUFACTURE.
US5264103A (en) * 1991-10-18 1993-11-23 Matsushita Electric Industrial Co., Ltd. Biosensor and a method for measuring a concentration of a substrate in a sample
US5582697A (en) * 1995-03-17 1996-12-10 Matsushita Electric Industrial Co., Ltd. Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same
US5628890A (en) 1995-09-27 1997-05-13 Medisense, Inc. Electrochemical sensor
JP3460183B2 (en) * 1996-12-24 2003-10-27 松下電器産業株式会社 Biosensor
US5759364A (en) * 1997-05-02 1998-06-02 Bayer Corporation Electrochemical biosensor
US5798031A (en) 1997-05-12 1998-08-25 Bayer Corporation Electrochemical biosensor
DE19747875A1 (en) * 1997-10-20 1999-05-06 Meinhard Prof Dr Knoll Method for measuring variable sizes and device for carrying out the method
CA2305922C (en) * 1999-08-02 2005-09-20 Bayer Corporation Improved electrochemical sensor design
US6841052B2 (en) * 1999-08-02 2005-01-11 Bayer Corporation Electrochemical-sensor design

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114544733A (en) * 2020-11-25 2022-05-27 五鼎生物技术股份有限公司 Biochemical test piece

Also Published As

Publication number Publication date
AU3820702A (en) 2002-11-28
US20060037870A1 (en) 2006-02-23
EP1262769A1 (en) 2002-12-04
CA2385342C (en) 2010-12-21
US7122110B2 (en) 2006-10-17
JP3612307B2 (en) 2005-01-19
AU784254B2 (en) 2006-03-02
ATE493644T1 (en) 2011-01-15
EP1262769B1 (en) 2010-12-29
DE60238733D1 (en) 2011-02-10
JP2003004691A (en) 2003-01-08
US20020175075A1 (en) 2002-11-28

Similar Documents

Publication Publication Date Title
CA2385342A1 (en) Improved electrochemical sensor
EP1343007B1 (en) Electrochemical sensor
EP1275732B1 (en) Electrochemical test sensor with an underfill detection system
KR100441152B1 (en) Biosensor
US8430999B2 (en) Method for detecting sample supply condition, and analyzer
DK1074832T4 (en) Electrochemical sensor with improved design
KR100340174B1 (en) Electrochemical Biosensor Test Strip, Fabrication Method Thereof and Electrochemical Biosensor
TW200538725A (en) Analyzer
JPH09222411A (en) Electrochemical sensor
EP1714148A1 (en) Electrochemical biosensor
EP2008087A2 (en) Laminated biosensor and its manufacturing method
KR101103682B1 (en) Bio-sensor
JP2020024221A (en) Keeping of electrode function during manufacture using protective layer
KR101058754B1 (en) Biological Sample Quantitative Measurement Method and Biological Sample Quantitative Measurement System
JP2004004057A (en) Biosensor, adapter used for the same and measuring apparatus
US10732138B2 (en) Biosensor strip

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKLA Lapsed

Effective date: 20120508