CA2388610A1 - Oral transmucosal drug dosage using solid solution - Google Patents

Oral transmucosal drug dosage using solid solution Download PDF

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Publication number
CA2388610A1
CA2388610A1 CA002388610A CA2388610A CA2388610A1 CA 2388610 A1 CA2388610 A1 CA 2388610A1 CA 002388610 A CA002388610 A CA 002388610A CA 2388610 A CA2388610 A CA 2388610A CA 2388610 A1 CA2388610 A1 CA 2388610A1
Authority
CA
Canada
Prior art keywords
solid solution
formulation
oral transmucosal
drug dosage
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002388610A
Other languages
French (fr)
Other versions
CA2388610C (en
Inventor
Hao Zhang
Jed Croft
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23697434&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2388610(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2388610A1 publication Critical patent/CA2388610A1/en
Application granted granted Critical
Publication of CA2388610C publication Critical patent/CA2388610C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats

Abstract

The present invention is directed toward formulation and method for oral transmucosal delivery of a pharmaceutical.
The invention provides a drug formulation comprising a solid pharmaceutial agent in solid solution with a dissolution agent. The formulation is administered into a patient's oral cavity, delivering the pharmaceutical agent by absorption through a patient's oral mucosal tissue. The formulation and method provide for improved oral mucosal delivery of the pharmaceutical agent.
CA002388610A 1999-10-27 2000-10-12 Oral transmucosal drug dosage using solid solution Expired - Fee Related CA2388610C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/428,071 US6264981B1 (en) 1999-10-27 1999-10-27 Oral transmucosal drug dosage using solid solution
US09/428,071 1999-10-27
PCT/US2000/028113 WO2001030288A1 (en) 1999-10-27 2000-10-12 Oral transmucosal drug dosage using solid solution

Publications (2)

Publication Number Publication Date
CA2388610A1 true CA2388610A1 (en) 2001-05-03
CA2388610C CA2388610C (en) 2007-08-21

Family

ID=23697434

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002388610A Expired - Fee Related CA2388610C (en) 1999-10-27 2000-10-12 Oral transmucosal drug dosage using solid solution

Country Status (12)

Country Link
US (1) US6264981B1 (en)
EP (1) EP1242013B2 (en)
JP (2) JP4815084B2 (en)
AT (1) ATE468845T2 (en)
AU (1) AU1079701A (en)
CA (1) CA2388610C (en)
DE (1) DE60044464D1 (en)
ES (1) ES2345870T5 (en)
HK (1) HK1050313A1 (en)
MX (1) MXPA02004235A (en)
PT (1) PT1242013E (en)
WO (1) WO2001030288A1 (en)

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