CA2391659A1 - Crystal forms of azithromycin - Google Patents

Crystal forms of azithromycin Download PDF

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Publication number
CA2391659A1
CA2391659A1 CA002391659A CA2391659A CA2391659A1 CA 2391659 A1 CA2391659 A1 CA 2391659A1 CA 002391659 A CA002391659 A CA 002391659A CA 2391659 A CA2391659 A CA 2391659A CA 2391659 A1 CA2391659 A1 CA 2391659A1
Authority
CA
Canada
Prior art keywords
azithromycin
crystal forms
infections
treatment
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002391659A
Other languages
French (fr)
Other versions
CA2391659C (en
Inventor
Zheng Jane Li
Andrew Vincent Trask
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27404135&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2391659(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Priority to CA002536501A priority Critical patent/CA2536501C/en
Priority to CA002500217A priority patent/CA2500217C/en
Priority to CA002536914A priority patent/CA2536914C/en
Publication of CA2391659A1 publication Critical patent/CA2391659A1/en
Application granted granted Critical
Publication of CA2391659C publication Critical patent/CA2391659C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2813—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

The invention relates to novel crystal forms of azithromycin, an antibiotic useful in the treatment of infections.
CA002391659A 2001-05-22 2002-05-01 Crystal forms of azithromycin Expired - Fee Related CA2391659C (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002536501A CA2536501C (en) 2001-05-22 2002-05-01 Crystal forms of azithromycin
CA002500217A CA2500217C (en) 2001-05-22 2002-05-01 Crystal forms of azithromycin
CA002536914A CA2536914C (en) 2001-05-22 2002-05-01 Crystal forms of azithromycin

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US29256501P 2001-05-22 2001-05-22
US60/292,565 2001-05-22
US29774101P 2001-06-12 2001-06-12
US60/297,741 2001-06-12
US34304101P 2001-12-21 2001-12-21
US60/343,041 2001-12-21
PCT/IB2002/001570 WO2002094843A1 (en) 2001-05-22 2002-05-01 Crystal forms of azithromycin

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CA002500217A Division CA2500217C (en) 2001-05-22 2002-05-01 Crystal forms of azithromycin
CA002536914A Division CA2536914C (en) 2001-05-22 2002-05-01 Crystal forms of azithromycin
CA002536501A Division CA2536501C (en) 2001-05-22 2002-05-01 Crystal forms of azithromycin

Publications (2)

Publication Number Publication Date
CA2391659A1 true CA2391659A1 (en) 2002-11-22
CA2391659C CA2391659C (en) 2006-05-30

Family

ID=27404135

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002391659A Expired - Fee Related CA2391659C (en) 2001-05-22 2002-05-01 Crystal forms of azithromycin

Country Status (35)

Country Link
US (10) US6977243B2 (en)
EP (1) EP1390377B1 (en)
JP (3) JP2004530703A (en)
KR (1) KR100574153B1 (en)
AP (1) AP2003002906A0 (en)
AR (1) AR036022A1 (en)
AT (2) ATE319730T1 (en)
AU (1) AU2002256846B2 (en)
BG (1) BG108370A (en)
BR (1) BR0209918A (en)
CA (1) CA2391659C (en)
CR (1) CR7159A (en)
CZ (1) CZ20033154A3 (en)
DE (2) DE60228345D1 (en)
DK (1) DK1390377T3 (en)
EA (2) EA009611B1 (en)
EE (1) EE200300575A (en)
ES (2) ES2258142T3 (en)
GE (1) GEP20084399B (en)
HU (1) HUP0400446A2 (en)
IL (1) IL158591A0 (en)
IS (1) IS7007A (en)
MA (1) MA27023A1 (en)
MX (1) MXPA03010028A (en)
MY (1) MY129319A (en)
NO (2) NO321894B1 (en)
NZ (2) NZ529118A (en)
PA (1) PA8545701A1 (en)
PE (1) PE20021064A1 (en)
PL (1) PL367091A1 (en)
PT (1) PT1390377E (en)
SK (1) SK14402003A3 (en)
TN (1) TNSN03121A1 (en)
WO (1) WO2002094843A1 (en)
YU (1) YU91603A (en)

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Also Published As

Publication number Publication date
BR0209918A (en) 2004-03-30
JP2006152002A (en) 2006-06-15
KR100574153B1 (en) 2006-04-25
EA200301115A1 (en) 2004-04-29
EP1390377B1 (en) 2006-03-08
CZ20033154A3 (en) 2004-04-14
US7081525B2 (en) 2006-07-25
EA009611B1 (en) 2008-02-28
GEP20084399B (en) 2008-06-10
CR7159A (en) 2004-02-23
NO321894B1 (en) 2006-07-17
WO2002094843A1 (en) 2002-11-28
US20050090459A1 (en) 2005-04-28
ES2310886T3 (en) 2009-01-16
NO20061049L (en) 2003-05-12
MY129319A (en) 2007-03-30
IS7007A (en) 2003-10-30
YU91603A (en) 2006-08-17
AU2002256846B2 (en) 2007-04-05
US7307156B2 (en) 2007-12-11
US20050256062A1 (en) 2005-11-17
EP1390377A1 (en) 2004-02-25
EE200300575A (en) 2004-04-15
MXPA03010028A (en) 2004-02-12
ATE404575T1 (en) 2008-08-15
HUP0400446A2 (en) 2004-09-28
AP2003002906A0 (en) 2003-12-31
NZ529118A (en) 2005-10-28
KR20040014525A (en) 2004-02-14
US6977243B2 (en) 2005-12-20
US20040043945A1 (en) 2004-03-04
US20030162730A1 (en) 2003-08-28
US20040043944A1 (en) 2004-03-04
JP4584162B2 (en) 2010-11-17
PT1390377E (en) 2006-06-30
PL367091A1 (en) 2005-02-21
NO20035177D0 (en) 2003-11-21
JP2004530703A (en) 2004-10-07
JP2007161726A (en) 2007-06-28
US7105179B2 (en) 2006-09-12
AR036022A1 (en) 2004-08-04
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ATE319730T1 (en) 2006-03-15
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US20040082527A1 (en) 2004-04-29
DE60209704D1 (en) 2006-05-04
PE20021064A1 (en) 2002-11-21
US20050256063A1 (en) 2005-11-17
PA8545701A1 (en) 2003-09-05
US20050192234A1 (en) 2005-09-01
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US20040138149A1 (en) 2004-07-15
DK1390377T3 (en) 2006-06-19
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