CA2392943A1 - Chemistry system for a clinical analyzer - Google Patents

Chemistry system for a clinical analyzer Download PDF

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Publication number
CA2392943A1
CA2392943A1 CA002392943A CA2392943A CA2392943A1 CA 2392943 A1 CA2392943 A1 CA 2392943A1 CA 002392943 A CA002392943 A CA 002392943A CA 2392943 A CA2392943 A CA 2392943A CA 2392943 A1 CA2392943 A1 CA 2392943A1
Authority
CA
Canada
Prior art keywords
reagent
recited
containment device
dispensing
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002392943A
Other languages
French (fr)
Other versions
CA2392943C (en
Inventor
Raymond Jakubowicz
David Angelo Tomasso
Michael W. Lacourt
James David. Shaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Clinical Diagnostics Inc
Original Assignee
Ortho Clinical Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Clinical Diagnostics Inc filed Critical Ortho Clinical Diagnostics Inc
Publication of CA2392943A1 publication Critical patent/CA2392943A1/en
Application granted granted Critical
Publication of CA2392943C publication Critical patent/CA2392943C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/103—General features of the devices using disposable tips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114998—Automated chemical analysis with conveyance of sample along a test line in a container or rack with treatment or replacement of aspirator element [e.g., cleaning, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/119163—Automated chemical analysis with aspirator of claimed structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Abstract

A clinical analyzer for determining the presence or amount of an analyte in a sample includes at least one reagent supply and at last one reaction containment device for containing a volume of sample and a volume of said at least one reagent from said at least one reagent supply. A wash-free delivery system introduces reagent into at least one reaction containment device without requiring washing of delivery components.

Claims (40)

We Claim:
1. A wash-free reagent delivery system for introducing a volume of at least one reagent into a reaction containment device in a clinical analyzer, said system including:
at least one reagent supply; and reagent wash-free delivery means for introducing a volume of at least one reagent from said at least one reagent supply to at least one reaction containment device.
2. A system as recited in Claim 1, including a plurality of fluid dispensing elements, each of said fluid dispensing elements used to aspirate a volume of reagent from said at least one reagent supply for single-use dispensing into said reaction containment device.
3. A system as recited in Claim 2, wherein said fluid dispensing elements are disposable.
4. A system as recited in Claim 1, wherein said reagent wash-free delivery means includes at least one reagent container retaining at least one reagent and a fluid dispensing element dedicated to said at least one reagent container for dispensing multiple volumes of reagent from said container.
5. A system as recited in Claim 4, wherein said fluid dispensing element is a metering tip.
6. A system as recited in Claim 5, wherein said metering tip is disposable.
7. A system as recited in Claim 5, wherein said reagent container separately retains more than one reagent and includes a corresponding number of fluid dispensing elements, each said element being dedicated to a said reagent.
8. A system as recited in Claim 4, wherein said wash-free delivery means includes means for moving said fluid dispensing element between said reagent container and a reaction containment device.
9. A system as recited in Claim 1, wherein said wash-free delivery means includes a reagent container having self-dispensing means for dispensing a predetermined amount of reagent into at least one reaction containment device.
10. A system as recited in Claim 9, wherein said self-dispensing means includes a pump mechanism.
11. A system as recited in Claim 9, wherein said self-dispensing means includes an actuator mechanism.
12. A clinical analyzer for determining the presence or amount of an analyte in a sample, said analyzer comprising:
at least one reagent supply;
at least one reaction containment device for containing a volume of sample and a volume of said at least one reagent from said at least one reagent supply; and wash-free delivery means for introducing said reagent into said at least one reaction containment device without requiring washing thereof.
13. An analyzer as recited in Claim 12, including sample delivery means for introducing, sample into said reaction containment device.
14. An analyzer as recited in Claim 12, said wash-free delivery means includes means for introducing sample and said at least one reagent into said reaction containment device.
15. An analyzer as recited in Claim 14, wherein said sample wash-free delivery means is separate from said reagent wash-free delivery means.
16. An analyzer as recited in Claim 12, wherein said at least one reaction containment device does not require washing following analyte detection therein.
17. An analyzer as recited in Claim 12, wherein said wash-free delivery means includes a plurality of fluid dispensing elements, each of said fluid dispensing elements providing a volume of a said reagent to said reaction containment device.
18. An analyzer as recited in Claim 17, wherein each of said fluid dispensing elements provide a single use dispersion of reagent to a single reaction containment device.
19. An analyzer as recited in Claim 17, wherein at least one fluid dispensing element can provide multiple use dispersions of one reagent from a dedicated specific reagent supply to more than one reaction containment devices.
20. An analyzer as recited in Claim 12, wherein said wash-free delivery means includes a reagent container having self-dispensing means for dispensing a predetermined volume of a reagent to at least one reaction containment device.
21. An analyzer as recited in Claim 20, wherein said self-dispensing means includes a pump mechanism.
22. An analyzer as recited in Claim 20, wherein said self-dispensing means includes an actuator mechanism.
23. An analyzer as recited in Claim 12, wherein said reaction containment device is a reaction cuvette.
24. An analyzer as recited in Claim 23, wherein said cuvette is disposable.
25. A clinical analyzer for determining the presence or amount of an analyte in a sample, said analyzer comprising:
at least one sample supply;
at least one reagent supply;

at least one reaction containment device for containing a volume of sample from said at least one sample supply and a volume of reagent from said at least one reagent supply; and reagent wash-free delivery means for introducing said volume from said at least one reagent supply into said reaction containment device.
26. A clinical analyzer as recited in Claim 25, including sample delivery means for introducing sample from said at least one sample supply into said at least one reaction containment device.
27. A clinical analyzer as recited in Claim 26, wherein said sample delivery means includes wash-free delivery means for introducing said volume of sample from said at least one sample supply into said reaction containment device.
28. A clinical analyzer as recited in Claim 25, including wash-free delivery means for introducing said sample from said sample supply and at least one reagent from said reagent supply into said reaction containment device.
29. A method for determining the amount or presence of an analyte in a sample using a clinical analyzer, said method including the steps of:
delivering a volume of sample to a reaction containment device;
delivering a volume of at least one reagent from a reagent supply to said reaction containment device using wash-free delivery means for introducing said at least one reagent to said reaction containment device thereby forming a detectable species in said containment device; and determining the formed species.
30. A method as recited in Claim 29, wherein said sample delivering step includes the steps of:
aspirating a volume of sample from a sample supply into a fluid dispensing member;
dispensing aspirated sample into said reaction containment device using said dispensing member.
27 3l. A method as recited in Claim 30, including the step of disposing of said dispensing member following said dispensing step.
32. A method as recited in Claim 29, wherein said reagent delivering step includes the steps of:
aspirating a volume of a reagent from said reagent supply into a fluid dispensing member;
and dispensing said volume of aspirated reagent from said fluid dispensing member into said reaction vessel.
33. A method as recited in Claim 32, including the step of disposing of said fluid dispensing member following said dispensing step.
34. A method as recited in Claim 29, wherein said reagent delivering step includes the additional steps of:
aspirating a first volume of a reagent into a first fluid dispensing element;
dispensing said reagent from said first fluid dispensing element into said reaction containment device;
disposing of said first fluid dispensing element;
aspirating a second volume of a reagent into a second fluid dispensing element; and dispensing said reagent from said second fluid dispensing element into said reaction containment device.
35. A method as recited in Claim 34, wherein said first volume is taken from a first reagent and said second volume is taken from a second reagent which is different than the first reagent.
36. A method as recited in Claim 35, wherein said second reagent aspirating and dispensing steps and said first reagent aspirating and dispensing steps are performed using a common metering mechanism.
37. A method as recited in Claim 32, wherein said reagent aspirating and dispensing steps further include the steps of:
repeatably using said fluid dispensing member to aspirate and dispense reagent into more than one reaction containment device, wherein said fluid dispensing member is dedicated for use with a first reagent container.
38. A method as recited in Claim 29, wherein at least one reagent fluid container includes a mechanism capable of dispensing a predetermined volume of reagent, said reagent delivering step includes the step of:
pumping a predetermined volume of reagent from said reagent supply into at least one reaction containment device.
39. A method as recited in Claim 29, wherein said reagent supply includes a mechanism capable of dispensing a predetermined amount of reagent, said reagent delivering step including the step of:
actuating said supply so as to cause a predetermined volume of reagent to be dispensed into at least one reaction containment device.
40. A method for conducting at least one assay in a clinical analyzer, said method including the steps of:
i) delivering a volume of sample into at least one reaction containment device;
ii) delivering a volume of at least one reagent from a reagent supply into said reaction containment device; and iii) repeating at least one of steps i) and ii) wherein a washing operation is not required between any of said delivering steps.
CA2392943A 2001-07-20 2002-07-11 Chemistry system for a clinical analyzer Expired - Fee Related CA2392943C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30683001P 2001-07-20 2001-07-20
US60/306,830 2001-07-20
US10/185,613 2002-06-28
US10/185,613 US7250303B2 (en) 2001-07-20 2002-06-28 Chemistry system for a clinical analyzer

Publications (2)

Publication Number Publication Date
CA2392943A1 true CA2392943A1 (en) 2003-01-20
CA2392943C CA2392943C (en) 2012-08-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2392943A Expired - Fee Related CA2392943C (en) 2001-07-20 2002-07-11 Chemistry system for a clinical analyzer

Country Status (7)

Country Link
US (2) US7250303B2 (en)
EP (1) EP1278067B1 (en)
JP (1) JP2003098182A (en)
AT (1) ATE356666T1 (en)
CA (1) CA2392943C (en)
DE (1) DE60218787T2 (en)
MX (1) MXPA02007100A (en)

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US7855084B2 (en) 2010-12-21
US7250303B2 (en) 2007-07-31
US20030022380A1 (en) 2003-01-30
US20080145939A1 (en) 2008-06-19
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CA2392943C (en) 2012-08-28
JP2003098182A (en) 2003-04-03
ATE356666T1 (en) 2007-04-15
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EP1278067B1 (en) 2007-03-14
DE60218787T2 (en) 2007-12-06

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