CA2396805A1 - Method and apparatus for automatic tissue staining - Google Patents

Method and apparatus for automatic tissue staining Download PDF

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Publication number
CA2396805A1
CA2396805A1 CA002396805A CA2396805A CA2396805A1 CA 2396805 A1 CA2396805 A1 CA 2396805A1 CA 002396805 A CA002396805 A CA 002396805A CA 2396805 A CA2396805 A CA 2396805A CA 2396805 A1 CA2396805 A1 CA 2396805A1
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CA
Canada
Prior art keywords
slide
specimen
reagent pack
identifier
staining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002396805A
Other languages
French (fr)
Other versions
CA2396805C (en
Inventor
Ken K. Tseung
Glenn Takayama
Norman K. Rhett
Mark V. Corl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lab Vision Corp
Original Assignee
Lab Vision Corporation
Ken K. Tseung
Glenn Takayama
Norman K. Rhett
Mark V. Corl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Vision Corporation, Ken K. Tseung, Glenn Takayama, Norman K. Rhett, Mark V. Corl filed Critical Lab Vision Corporation
Publication of CA2396805A1 publication Critical patent/CA2396805A1/en
Application granted granted Critical
Publication of CA2396805C publication Critical patent/CA2396805C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates

Abstract

A method and apparatus for specimen slide (710) preparation is disclosed. Th e method and apparatus of the present invention uses slide trays (700) that ha ve receptacles for at least one specimen slide (710) and an associated reagent park (720). The specimen slide (710) and/or reagent pack (720) includes an identifier (420) that specifies a particular slide preparation protocol that should be followed. The method and apparatus reads the identifier (420) to determine the particular slide preparation protocol and then prepares the specimen slide according to the particular slide preparation protocol. The apparatus may obtain some or all of the reagents needed for the particular slide preparation protocol from the reagent pack (400).

Claims (27)

1. A method of operating an autostainer device comprising accepting a slide tray, the slide tray having at least one specimen slide and preparing the specimen slide according to a slide preparation protocol, characterised in that the slide tray has a reagent pack associated with the specimen slide, the reagent pack or the specimen slide comprising a first identifier that specifies a particular slide preparation protocol, and in that the method includes reading the first identifier, and preparing the specimen slide according to the particular slide preparation protocol.
2. The method of Claim 1 further comprising pausing the device during operation and restarting the device after adding an additional specimen slide onto the slide tray.
3. The method as claimed in either Claim 1 or Claim 2 wherein the reagent pack is associated with the specimen slide by being adjacent to the specimen slide.
4. The method as claimed in either Claim 1 or Claim 2 wherein the reagent pack comprises the first identifier and wherein the reagent pack is associated with the specimen slide by having a second identifier on the specimen slide that is the same as the first identifier.
5. The method as claimed in either Claim 1 or Claim 2 wherein the specimen slide comprises the first identifier and wherein the reagent pack is associated with the specimen slide by having a second identifier that is the same as the first identifier.
6. The method as claimed in any preceding claim wherein said reagent pack comprises a set of wells, each well containing a reagent needed for the particular slide preparation protocol.
7. The method as claimed in any preceding claim wherein said reagent pack comprise a peel-off identifier, the peel-off identifier for placement on the specimen slide.
8. A slide rack for a slide staining apparatus, the slide rack comprising a first receptacle for accepting a specimen slide, characterised in that the slide rack further comprises a second receptacle for accepting a reagent pack and in that the reagent pack contains at least one reagent needed to prepare said specimen slide and an identifier that identifies a slide preparation protocol for the specimen slide.
9. The slide rack is claimed in Claim 8 further wherein said first receptacle and said second receptacle are adjacent to each other.
10. A reagent pack for a slide staining apparatus, the reagent pack comprising a set of wells, said well containing reagents for a specific slide preparation protocol characterised in that the reagent pack further comprises an identifier associated with the specific slide preparation protocol.
11. The reagent pack as claimed in Claim 10 wherein the identifier comprises a peel-off sticker for placement on an associated specimen slide.
12. An apparatus for staining specimen slides, comprising at least one slide tray, for holding at least one specimen slide and an automatic staining head assembly, said automatic staining head assembly for obtaining reagents and depositing reagents on the specimen slide, characterised in that the slide tray has a reagent pack associated with the specimen slide, the associated reagent pack having reagents needed for processing the specimen slide, in that the specimen slide or reagent pack has an identifier associated with a slide preparation protocol, and in that the apparatus further comprises an input device for reading the identifier, a control system for controlling the automatic staining head assembly to prepare the specimen slide according to the slide preparation protocol, a pause input for pausing the apparatus during processing and a restart input for restarting the apparatus after adding a new specimen slide onto the slide tray.
13. An apparatus for staining specimen slides, comprising more than one slide tray, the slide tray for holding more than one specimen slide, an automatic staining head assembly, the automatic staining head assembly for depositing reagents on the specimen slides, and a control system coupled to the automatic staining head assembly for controlling the automatic staining head assembly to prepare the specimen slides during a staining run characterised in that the automatic staining head assembly further comprises an input device for reading identifiers that specify slide preparation protocols to perform in that the apparatus further comprises a pause input for pausing the apparatus during the staining run and a restart input for restarting the apparatus after adding new specimen slides onto one of the slide trays, and in that the control system causes the automatic staining head assembly to read a new set of identifiers associated with the new specimen slides to add the new specimen slides to the staining run.
14. The apparatus as claimed in Claim 13 wherein said apparatus further comprises reagent packs.
15. The apparatus as claimed in Claim 14 wherein each reagent pack comprises a set of wells, each well containing a reagent needed for a particular slide preparation protocol.
16. The apparatus as claimed in either Claim 14 or Claim 15 wherein the identifiers comprises a barcode on each said reagent pack.
17. The apparatus as claimed in any one of Claims 13 to 15 wherein the identifiers comprise a set of barcodes on the specimen slides.
18. The apparatus as claimed in any one of the Claims 13 to 17 further comprising a STAT restart input, the STAT restart input for restarting the apparatus after adding new specimen slides onto one of said slide trays, wherein the new specimen slides are given high priority.

18. The slide rack as claimed in claim 17 further wherein said reagent pack further comprises an identifier that identifies a slide preparation protocol for said specimen slide.
19. The slide rack as claimed in claim 17 further wherein said first receptacle and said second receptacle are adjacent to each other.
20. A reagent pack for a slide staining apparatus, said reagent pack comprising:
a set of wells, said well containing reagents for a specific slide preparation protocol; and an identifier, said identifier associated with said slide preparation protocol.
21. The reagent pack as claimed in claim 20 wherein said identifier comprises a peel-off sticker for placement on an associated specimen slide.
22. The reagent pack as claimed in claim 20 further wherein said identifier comprises a peel-off sticker for placement on an associated specimen slide.
23. A slide staining apparatus, said apparatus comprising:
at least one slide rack for holding a slide specimen to be prepared;
and a tiltable sink assembly, said tiltable sink assembly having a first drain hole on a first side such that liquid material drains through said first drain hole when tilted down on said first side, said tiltable sink assembly having a second drain hole on a second side such that liquid material drains through said second drain hole when tilted down on said second side.
24. The apparatus as claimed in claim 23 wherein said first drain hole is coupled to a sewage system.
25. The apparatus as claimed in claim 23 wherein said second drain hole is coupled to a hazardous waste container.
26. The apparatus as claimed in claim 23 wherein said second drain hole is coupled to a corrugated tube.
27. An apparatus for staining specimen slides, said apparatus comprising:
at least one slide tray, said slide tray for holding at least one specimen slide and an associated reagent pack, said associated reagent pack having reagents needed for processing said specimen slide; and an automatic staining head assembly, said automatic staining head assembly for obtaining said reagents from said associated reagent pack and depositing reagents on said specimen slide.
CA2396805A 2000-01-14 2001-01-08 Method and apparatus for automatic tissue staining Expired - Lifetime CA2396805C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/483,248 US6746851B1 (en) 2000-01-14 2000-01-14 Method for automated staining of specimen slides
US09/483,248 2000-01-14
PCT/US2001/000512 WO2001051909A1 (en) 2000-01-14 2001-01-08 Method and apparatus for automatic tissue staining

Publications (2)

Publication Number Publication Date
CA2396805A1 true CA2396805A1 (en) 2001-07-19
CA2396805C CA2396805C (en) 2010-07-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2396805A Expired - Lifetime CA2396805C (en) 2000-01-14 2001-01-08 Method and apparatus for automatic tissue staining

Country Status (11)

Country Link
US (1) US6746851B1 (en)
EP (1) EP1247084B1 (en)
JP (2) JP5189721B2 (en)
CN (1) CN1236297C (en)
AT (1) ATE355513T1 (en)
AU (1) AU2001226345A1 (en)
CA (1) CA2396805C (en)
DE (1) DE60126910T2 (en)
DK (1) DK1247084T3 (en)
ES (1) ES2282227T3 (en)
WO (1) WO2001051909A1 (en)

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Also Published As

Publication number Publication date
EP1247084B1 (en) 2007-02-28
CN1404573A (en) 2003-03-19
JP2013040974A (en) 2013-02-28
JP2003519791A (en) 2003-06-24
WO2001051909A1 (en) 2001-07-19
US6746851B1 (en) 2004-06-08
ATE355513T1 (en) 2006-03-15
AU2001226345A1 (en) 2001-07-24
DE60126910D1 (en) 2007-04-12
CN1236297C (en) 2006-01-11
DK1247084T3 (en) 2007-06-25
ES2282227T3 (en) 2007-10-16
DE60126910T2 (en) 2007-11-08
EP1247084A1 (en) 2002-10-09
CA2396805C (en) 2010-07-20
JP5189721B2 (en) 2013-04-24
JP5444443B2 (en) 2014-03-19

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