CA2397827A1 - Reaction block for parallel synthetic chemistry and vessel therefor - Google Patents

Reaction block for parallel synthetic chemistry and vessel therefor Download PDF

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Publication number
CA2397827A1
CA2397827A1 CA002397827A CA2397827A CA2397827A1 CA 2397827 A1 CA2397827 A1 CA 2397827A1 CA 002397827 A CA002397827 A CA 002397827A CA 2397827 A CA2397827 A CA 2397827A CA 2397827 A1 CA2397827 A1 CA 2397827A1
Authority
CA
Canada
Prior art keywords
reaction
reaction chamber
vessels
discharge channel
synthetic chemistry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002397827A
Other languages
French (fr)
Other versions
CA2397827C (en
Inventor
Dieter Voegelin
Claus Muller
Roman Bar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2397827A1 publication Critical patent/CA2397827A1/en
Application granted granted Critical
Publication of CA2397827C publication Critical patent/CA2397827C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/40—Removing or ejecting moulded articles
    • B29C45/44—Removing or ejecting moulded articles for undercut articles
    • B29C45/4471—Removing or ejecting moulded articles for undercut articles using flexible or pivotable undercut forming elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00283—Reactor vessels with top opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
    • B01J2219/0031—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks the racks or blocks being mounted in stacked arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00331—Details of the reactor vessels
    • B01J2219/00333—Closures attached to the reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B01J2219/00405—Sliding valves
    • B01J2219/00407—In multiple arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00414—Means for dispensing and evacuation of reagents using suction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/045—Connecting closures to device or container whereby the whole cover is slidable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

A reaction vessel, particularly for use in parallel synthetic chemistry, is characterized by an inner structure, namely a reaction chamber and a discharge channel which are interconnected. The interconnection preferably consist of a connection channel between the bottom of the reaction chamber and the discharge channel so that almost any liquid in the reaction chamber can be removed through the discharge channel. The connection channel may be molded by an extension hinged to the core molding the reaction chamber, so that the reaction vessel can be conveniently manufactured by injection molding. A reaction block particularly for use with these reaction vessels comprises a closure means covering the open ends of the discharge channel and the reaction chamber of at least two of the reaction vessels. By guiding means the closure means is directed to perform a generally linear movement in moving from the opening to the closing position, and during this movement, to move towards the open ends of the vessels in order to close them with a force withstanding also an overpressure possibly developing within the vessels.
CA002397827A 2001-09-07 2002-08-13 Reaction block for parallel synthetic chemistry and vessel therefor Expired - Lifetime CA2397827C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01810859.7 2001-09-07
EP01810859A EP1291074A1 (en) 2001-09-07 2001-09-07 Reaction block for parallel synthetic chemistry and vessel therefor

Publications (2)

Publication Number Publication Date
CA2397827A1 true CA2397827A1 (en) 2003-03-07
CA2397827C CA2397827C (en) 2008-04-29

Family

ID=8184124

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002397827A Expired - Lifetime CA2397827C (en) 2001-09-07 2002-08-13 Reaction block for parallel synthetic chemistry and vessel therefor

Country Status (7)

Country Link
US (2) US20030170147A1 (en)
EP (1) EP1291074A1 (en)
JP (1) JP4681793B2 (en)
AT (1) ATE359117T1 (en)
CA (1) CA2397827C (en)
DE (1) DE60219400T2 (en)
ES (1) ES2284782T3 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3805352B1 (en) * 2005-05-25 2006-08-02 株式会社エンプラス Fluid handling device and fluid handling unit used therefor
JP4680037B2 (en) 2005-11-14 2011-05-11 株式会社エンプラス Fluid handling device and fluid handling unit used therefor
EP1872855A1 (en) * 2006-06-27 2008-01-02 F.Hoffmann-La Roche Ag Plate for equilibrating a fluid
DE102006030068A1 (en) * 2006-06-28 2008-01-03 M2P-Labs Gmbh Apparatus and method for the supply and removal of fluids in shaken microreactors arrays
TWI737631B (en) * 2015-10-01 2021-09-01 美商柏克萊燈光有限公司 Well-plate incubator
CA3045898A1 (en) 2016-12-01 2018-06-07 Berkeley Lights, Inc. Well-plate incubator
CN108819126A (en) * 2018-07-25 2018-11-16 东莞广泽汽车饰件有限公司 A kind of injection mold of car trim

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1171178B (en) * 1960-02-06 1964-05-27 Martin Christ Fa Centrifuge cell
GB1064901A (en) * 1965-01-19 1967-04-12 Alfred George Wright Improvements relating to centrifuges
JPS5866852A (en) * 1981-10-19 1983-04-21 Olympus Optical Co Ltd U-shaped reaction vessel
US4605536A (en) * 1984-05-29 1986-08-12 Veb Metaplast Quedlinburg Cuvette for projection display of chemical experiments
JPS6356420A (en) * 1986-08-27 1988-03-11 Fukuraito Kk Manufacture of dental disposable syringe
JPH01317733A (en) * 1988-06-20 1989-12-22 Terumo Corp Bottomed cylindrical molded product, mold and method for preparing the same
US5395006A (en) * 1993-04-29 1995-03-07 Verma; Kuldeep Fermentation vessels and closures therefor
US5641681A (en) * 1995-04-17 1997-06-24 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Device and method for screening crystallization conditions in solution crystal growth
GB9515831D0 (en) * 1995-08-02 1995-10-04 The Technology Partnership Plc Automated chemical synthesis system
US5746982A (en) * 1996-02-29 1998-05-05 Advanced Chemtech, Inc. Apparatus for automated synthesis of chemical compounds
US5972694A (en) * 1997-02-11 1999-10-26 Mathus; Gregory Multi-well plate
EP0991464B1 (en) * 1997-06-16 2002-01-09 Chemspeed Ltd. Reaction vessel holder
US5801055A (en) * 1997-09-10 1998-09-01 Becton Dickinson And Company Multi-well culture dish assembly
DE59802862D1 (en) * 1997-11-08 2002-02-28 Chemspeed Ltd DEVICE FOR HOLDING TEMPERATURE AND SHAKABLE REACTION VESSELS
DE19915811C2 (en) * 1999-04-08 2001-05-03 Boehringer Ingelheim Pharma Reaction vessel
US6811752B2 (en) * 2001-05-15 2004-11-02 Biocrystal, Ltd. Device having microchambers and microfluidics
US20070140925A1 (en) * 2005-11-11 2007-06-21 Phelps David Y Automated chemical synthesizer and method for synthesis using same

Also Published As

Publication number Publication date
US20030170147A1 (en) 2003-09-11
DE60219400D1 (en) 2007-05-24
JP2003190773A (en) 2003-07-08
ES2284782T3 (en) 2007-11-16
EP1291074A1 (en) 2003-03-12
CA2397827C (en) 2008-04-29
ATE359117T1 (en) 2007-05-15
JP4681793B2 (en) 2011-05-11
US7794668B2 (en) 2010-09-14
DE60219400T2 (en) 2007-12-27
US20060263273A1 (en) 2006-11-23

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20220815