CA2402247A1 - Biodegradable immunomodulatory formulations and methods for use thereof - Google Patents
Biodegradable immunomodulatory formulations and methods for use thereof Download PDFInfo
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- CA2402247A1 CA2402247A1 CA002402247A CA2402247A CA2402247A1 CA 2402247 A1 CA2402247 A1 CA 2402247A1 CA 002402247 A CA002402247 A CA 002402247A CA 2402247 A CA2402247 A CA 2402247A CA 2402247 A1 CA2402247 A1 CA 2402247A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Abstract
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or nanocarrier.
Claims (71)
1. An immunomodulatory polynucleotide/microcarrier (IMP/MC) complex, comprising:
a polynucleotide comprising an immunostimulatory sequence (ISS) linked to a biodegradable microcarrier (MC), wherein the ISS comprises the sequence 5'-C, G-3' and wherein said MC is less than 10 µm in size.
a polynucleotide comprising an immunostimulatory sequence (ISS) linked to a biodegradable microcarrier (MC), wherein the ISS comprises the sequence 5'-C, G-3' and wherein said MC is less than 10 µm in size.
2. The IMP/MC complex of claim 1, wherein said polynucleotide is covalently linked to said microcarrier.
3. The IMP/MC complex of claim 1, wherein said polynucleotide is non-covalently linked to said microcarrier.
4. The IMP/MC complex of claim 1, wherein said microcarrier is a liquid phase microcarrier.
5. The IMP/MC complex of claim 1, wherein said microcarrier is a solid phase microcarrier.
6. The IMP/MC complex of claim 1, wherein said microcarrier is from 25 nm to 5 µm in size.
7. The IMP/MC complex of claim 6, wherein said microcarrier is from 1.0 ~m to 2.0 µm in size.
8. The IMP/MC complex of claim 7, wherein said microcarrier is 1.4 µm in size.
9. The IMP/MC complex of claim 7, wherein said microcarrier is cationic.
10. The IMP/MC complex of claim 1, wherein said complex is antigen-free.
11. The IMP/MC complex of claim 1, wherein the ISS comprises the sequence 5'-T, C, G-3'.
12. The IMP/MC complex of claim 1, wherein the ISS comprises the sequence 5'-C, G, pyrimidine, pyrimidine, C, G-3'.
13. The IMP/MC complex of claim 1, wherein the ISS comprises the sequence 5'-purine, purine, C, G, pyrimidine, pyrimidine, C, G-3'.
14. The IMP/MC complex of claim 1, wherein the ISS comprises the sequence SEQ
ID NO:1.
ID NO:1.
15. A method of modulating an immune response in an individual comprising administering to an individual an immunomodulatory polynucleotide/microcarrier (IMP/MC) complex, said complex comprising a polynucleotide comprising an immunostimulatory sequence (ISS) linked to a biodegradable microcarrier (MC), wherein the ISS comprises the sequence 5'-C, G-3' and wherein said MC is less than 10 µm in size, in an amount sufficient to modulate an immune response in said individual.
16. The method of claim 15, wherein said microcarrier is a solid phase microcarrier.
17. The method of claim 15, wherein said microcarrier is a liquid phase microcarrier.
18. The method of claim 15, wherein the IMP/MC complex is covalently linked.
19. The method of claim 15, wherein the IMP/MC complex is non-covalently linked.
20. The method of claim 15, wherein said complex is antigen-free.
21. The method of claim 15, wherein a Th1-type immune response is stimulated.
22. The method of claim 15, wherein a Th2-type immune response is suppressed.
23. The method of claim 15, wherein the ISS comprises the sequence 5'-T, C, G-3'.
24. The method of claim 15, wherein the ISS comprises the sequence 5'-C, G, pyrimidine, pyrimidine, C, G-3'.
25. The IMP/MC complex of claim 15, wherein the ISS comprises the sequence 5'-purine, purine, C, G, pyrimidine, pyrimidine, C, G-3'.
26. The IMP/MC complex of claim 15, wherein the ISS comprises the sequence SEQ ID NO:1.
27. A method of increasing interferon-gamma (IFN-.gamma.) in an individual, comprising:
administering an effective amount of an immunomodulatory polynucleotide/microcarrier (IMP/MC) complex to said individual, said complex comprising a polynucleotide comprising an immunostimulatory sequence (ISS) linked to a biodegradable microcarrier (MC), wherein the ISS comprises the sequence 5'-C, G-3', wherein said MC is less than 10 µm in size and wherein an effective amount is an amount sufficient to increase IFN-.gamma. in said individual.
administering an effective amount of an immunomodulatory polynucleotide/microcarrier (IMP/MC) complex to said individual, said complex comprising a polynucleotide comprising an immunostimulatory sequence (ISS) linked to a biodegradable microcarrier (MC), wherein the ISS comprises the sequence 5'-C, G-3', wherein said MC is less than 10 µm in size and wherein an effective amount is an amount sufficient to increase IFN-.gamma. in said individual.
28. The method of claim 27, wherein said microcarrier is a solid phase microcarrier.
29. The method of claim 27, wherein said microcarrier is a liquid phase microcarrier.
30. The method of claim 27, wherein the IMP/MC complex is covalently linked.
31. The method of claim 27, wherein the IMP/MC complex is non-covalently linked.
32. The method of claim 27, wherein said complex is antigen-free.
33. The method of claim 27, wherein the ISS comprises the sequence 5'-T, C, G-3'.
34. The method of claim 27, wherein the ISS comprises the sequence 5'-C, G, pyrimidine, pyrimidine, C, G-3'.
35. The IMP/MC complex of claim 27, wherein the ISS comprises the sequence 5'-purine, purine, C, G, pyrimidine, pyrimidine, C, G-3'.
36. The IMP/MC complex of claim 27, wherein the ISS comprises the sequence SEQ ID NO:1.
37. A method of increasing interferon-alpha (IFN-.alpha.) in an individual, comprising:
administering an effective amount of an immunomodulatory polynucleotide/microcarrier (IMP/MC) complex to said individual, said complex comprising a polynucleotide comprising an immunostimulatory sequence (ISS) linked to a biodegradable microcarrier (MC), wherein the ISS comprises the sequence 5'-C, G-3', wherein said MC is less than 10 µm in size and wherein an effective amount is an amount sufficient to increase IFN-.alpha. in said individual.
administering an effective amount of an immunomodulatory polynucleotide/microcarrier (IMP/MC) complex to said individual, said complex comprising a polynucleotide comprising an immunostimulatory sequence (ISS) linked to a biodegradable microcarrier (MC), wherein the ISS comprises the sequence 5'-C, G-3', wherein said MC is less than 10 µm in size and wherein an effective amount is an amount sufficient to increase IFN-.alpha. in said individual.
38. The method of claim 37, wherein said individual has a viral infection.
39. The method of claim 37, wherein said microcarrier is a solid phase microcarrier.
40. The method of claim 37, wherein said microcarrier is a liquid phase microcarrier.
41. The method of claim 37, wherein the IMP/MC complex is covalently linked.
42. The method of claim 37, wherein the IMP/MC complex is non-covalently linked.
43. The method of claim 37, wherein said complex is antigen-free.
44. The method of claim 37, wherein the ISS comprises the sequence 5'-T, C, G-3'.
45. The method of claim 37, wherein the ISS comprises the sequence 5'-C, G, pyrimidine, pyrimidine, C, G-3'.
46. The IMP/MC complex of claim 37, wherein the ISS comprises the sequence 5'-purine, purine, C, G, pyrimidine, pyrimidine, C, G-3'.
47. The IMP/MC complex of claim 37, wherein the ISS comprises the sequence SEQ ID NO:1.
48. A method of reducing levels of IgE in an individual, comprising:
administering an effective amount of an immunomodulatory polynucleotide/microcarrier (IMP/MC) complex to said individual, said complex comprising a polynucleotide comprising an immunostimulatory sequence (ISS) linked to a biodegradable microcarrier (MC), wherein the ISS comprises the sequence 5'-C, G-3', wherein said MC is less than 10 µm in size and wherein an effective amount is an amount sufficient to reducing levels of IgE in said individual.
administering an effective amount of an immunomodulatory polynucleotide/microcarrier (IMP/MC) complex to said individual, said complex comprising a polynucleotide comprising an immunostimulatory sequence (ISS) linked to a biodegradable microcarrier (MC), wherein the ISS comprises the sequence 5'-C, G-3', wherein said MC is less than 10 µm in size and wherein an effective amount is an amount sufficient to reducing levels of IgE in said individual.
49. The method of claim 48, wherein said microcarrier is a solid phase microcarrier.
50. The method of claim 48, wherein said microcarrier is a liquid phase microcarrier.
51. The method of claim 48, wherein the IMP/MC complex is covalently linked.
52. The method of claim 48, wherein the IMP/MC complex is non-covalently linked.
53. The method of claim 48, wherein said complex is antigen-free.
54. The method of claim 48, wherein the ISS comprises the sequence 5'-T, C, G-3'
55. The method of claim 48, wherein the ISS comprises the sequence 5'-C, G;
pyrimidine, pyrimidine, C, G-3'.
pyrimidine, pyrimidine, C, G-3'.
56. The IMP/MC complex of claim 48, wherein the ISS comprises the sequence 5'-purine, purine, C, G, pyrimidine, pyrimidine, C, G-3'.
57. The IMP/MC complex of claim 48, wherein the ISS comprises the sequence SEQ ID NO:1.
58. A kit, comprising:
a container comprising an immunomodulatory polynucleotide/microcarrier (IMP/MC) complex, wherein the ISS comprises the sequence 5'-C, G-3', wherein said MC
is a biodegradable MC and wherein said MC is less than 10 µm in size; and instructions for use of IMP/MC complex in immunodulation of an individual.
a container comprising an immunomodulatory polynucleotide/microcarrier (IMP/MC) complex, wherein the ISS comprises the sequence 5'-C, G-3', wherein said MC
is a biodegradable MC and wherein said MC is less than 10 µm in size; and instructions for use of IMP/MC complex in immunodulation of an individual.
59. The kit of claim 58, wherein said polynucleotide is covalently linked to said microcarrier.
60. The kit of claim 58, wherein said polynucleotide is non-covalently linked to said microcarrier.
61. The kit of claim 58, wherein said microcarrier is a liquid phase microcarrier.
62. The kit of claim 58, wherein said microcarrier is a solid phase microcarrier.
63. The kit of claim 58, wherein said microcarrier is from 25 nm to 5 µm in size.
64. The kit of claim 63, wherein said microcarrier is from 1.0 µm to 2.0 µm in size.
65. The kit of claim 64, wherein said microcarrier is 1.4 µm in size.
66. The kit of claim 58, wherein said microcarrier is cationic.
67. The kit of claim 58, wherein said complex is antigen-free.
68. The kit of claim 58, wherein the ISS comprises the sequence 5'-T, C, G-3'.
69. The kit of claim 58, wherein the ISS comprises the sequence 5'-C, G, pyrimidine, pyrimidine, C, G-3'.
70. The kit of claim 58, wherein the ISS comprises the sequence 5'-purine, purine, C, G, pyrimidine, pyrimidine, C, G-3'.
71. The kit of claim 58, wherein the ISS comprises the sequence SEQ ID NO:1.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18830300P | 2000-03-10 | 2000-03-10 | |
US60/188,303 | 2000-03-10 | ||
US09/802,359 US20030129251A1 (en) | 2000-03-10 | 2001-03-09 | Biodegradable immunomodulatory formulations and methods for use thereof |
US09/802,359 | 2001-03-09 | ||
PCT/US2001/007848 WO2001068144A2 (en) | 2000-03-10 | 2001-03-12 | Biodegradable immunomodulatory formulations and methods for use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2402247A1 true CA2402247A1 (en) | 2001-09-20 |
CA2402247C CA2402247C (en) | 2011-11-01 |
Family
ID=26883938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2402247A Expired - Fee Related CA2402247C (en) | 2000-03-10 | 2001-03-12 | Biodegradable immunomodulatory formulations and methods for use thereof |
Country Status (8)
Country | Link |
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US (4) | US20030129251A1 (en) |
EP (1) | EP1261378B1 (en) |
JP (1) | JP2003526682A (en) |
AT (1) | ATE460181T1 (en) |
AU (2) | AU2001245631B2 (en) |
CA (1) | CA2402247C (en) |
DE (1) | DE60141508D1 (en) |
WO (1) | WO2001068144A2 (en) |
Families Citing this family (81)
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US6727230B1 (en) * | 1994-03-25 | 2004-04-27 | Coley Pharmaceutical Group, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
EP0855184A1 (en) * | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination |
US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
US20040006034A1 (en) * | 1998-06-05 | 2004-01-08 | Eyal Raz | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
IL139813A0 (en) | 1998-05-22 | 2002-02-10 | Loeb Health Res Inst At The Ot | Methods and products for inducing mucosal immunity |
US6693086B1 (en) * | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
AU4343700A (en) | 1999-04-12 | 2000-11-14 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Oligodeoxynucleotide and its use to induce an immune response |
US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
US7223398B1 (en) * | 1999-11-15 | 2007-05-29 | Dynavax Technologies Corporation | Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof |
WO2001051500A1 (en) | 2000-01-14 | 2001-07-19 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
US20010044416A1 (en) * | 2000-01-20 | 2001-11-22 | Mccluskie Michael J. | Immunostimulatory nucleic acids for inducing a Th2 immune response |
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JP2010511408A (en) * | 2006-12-04 | 2010-04-15 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ | Compositions and methods for treating cancer with CpG rich DNA and cupredoxins |
WO2009060281A2 (en) * | 2007-11-06 | 2009-05-14 | Coley Pharmaceutical Gmbh | Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties |
AU2010254551B2 (en) * | 2009-05-27 | 2016-10-20 | Selecta Biosciences, Inc. | Immunomodulatory agent-polymeric compounds |
WO2010138914A1 (en) | 2009-05-29 | 2010-12-02 | Oxonica Materials Inc. | Sers-active particles or substances and uses thereof |
US8546550B2 (en) * | 2010-11-16 | 2013-10-01 | Selecta Biosciences, Inc. | Immunostimulatory oligonucleotides |
-
2001
- 2001-03-09 US US09/802,359 patent/US20030129251A1/en not_active Abandoned
- 2001-03-12 EP EP01918571A patent/EP1261378B1/en not_active Expired - Lifetime
- 2001-03-12 WO PCT/US2001/007848 patent/WO2001068144A2/en active IP Right Grant
- 2001-03-12 AU AU2001245631A patent/AU2001245631B2/en not_active Ceased
- 2001-03-12 AU AU4563101A patent/AU4563101A/en active Pending
- 2001-03-12 CA CA2402247A patent/CA2402247C/en not_active Expired - Fee Related
- 2001-03-12 JP JP2001566707A patent/JP2003526682A/en active Pending
- 2001-03-12 AT AT01918571T patent/ATE460181T1/en not_active IP Right Cessation
- 2001-03-12 DE DE60141508T patent/DE60141508D1/en not_active Expired - Lifetime
- 2001-08-10 US US09/927,422 patent/US7250403B2/en not_active Expired - Lifetime
-
2007
- 2007-06-19 US US11/820,592 patent/US8124590B2/en not_active Expired - Fee Related
-
2012
- 2012-01-25 US US13/358,492 patent/US8669237B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20120121622A1 (en) | 2012-05-17 |
WO2001068144A2 (en) | 2001-09-20 |
US20030022852A1 (en) | 2003-01-30 |
US8669237B2 (en) | 2014-03-11 |
US20030129251A1 (en) | 2003-07-10 |
AU4563101A (en) | 2001-09-24 |
US20110038896A1 (en) | 2011-02-17 |
ATE460181T1 (en) | 2010-03-15 |
JP2003526682A (en) | 2003-09-09 |
DE60141508D1 (en) | 2010-04-22 |
EP1261378B1 (en) | 2010-03-10 |
AU2001245631B2 (en) | 2005-08-25 |
EP1261378A2 (en) | 2002-12-04 |
CA2402247C (en) | 2011-11-01 |
US7250403B2 (en) | 2007-07-31 |
US8124590B2 (en) | 2012-02-28 |
WO2001068144A3 (en) | 2002-05-16 |
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