CA2402268A1 - Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections - Google Patents

Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections Download PDF

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Publication number
CA2402268A1
CA2402268A1 CA002402268A CA2402268A CA2402268A1 CA 2402268 A1 CA2402268 A1 CA 2402268A1 CA 002402268 A CA002402268 A CA 002402268A CA 2402268 A CA2402268 A CA 2402268A CA 2402268 A1 CA2402268 A1 CA 2402268A1
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CA
Canada
Prior art keywords
sequence
rsv
iss
purine
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002402268A
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French (fr)
Other versions
CA2402268C (en
Inventor
Gary Van Nest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dynavax Technologies Corp
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Dynavax Technologies Corporation
Gary Van Nest
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Publication date
Application filed by Dynavax Technologies Corporation, Gary Van Nest filed Critical Dynavax Technologies Corporation
Publication of CA2402268A1 publication Critical patent/CA2402268A1/en
Application granted granted Critical
Publication of CA2402268C publication Critical patent/CA2402268C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

Abstract

The invention provides methods of preventing and/or treating infection by a respiratory virus such as respiratory syncytial virus (RSV), particularly reducing infection and/or one or more symptoms of respiratory virus infection. A polynucleotide comprising an immunostimulatory sequence (an “ISS”) is administered to an individual which is at risk of being exposed to a respiratory virus, has been exposed to a respiratory virus or is infected with a respiratory virus. The ISS is administered without any antigens of the respiratory virus. Administration of the ISS results in reduced incidence and/or severity of one or more symptoms of respiratory virus infection.

Claims (15)

1. A method of suppressing a respiratory syncytial virus (RSV) infection in an individual who has been exposed to RSV, comprising administering a composition comprising a polynucleotide comprising an immunostimulatory sequence (ISS) to said individual, wherein the ISS comprises the sequence 5'-C, G-3', wherein an RSV
antigen is not administered in conjunction with administration of said composition, and wherein said composition is administered in an amount sufficient to suppress a RSV
infection.
2. The method of claim 1, wherein the ISS comprises the sequence 5'-T, C, G-
3'.
3. The method of claim 1, wherein the ISS comprises the sequence 5'-purine, purine, C, G, pyrimidine, pyrimidine, C, G-3' or 5'-purine, purine, C, G, pyrimidine, pyrimidine, C, C-3'.
4. The method of claim 3, wherein the ISS comprises a sequence selected from the group consisting of 5'-AACGTTCC-3', 5'-AACGTTCG-3', 5'-GACGTTCC-3', and 5'-GACGTTCG-3' .
5. The method of claim 1, wherein the ISS comprises the sequence 5'-TGACTGTGAACGTTCGAGATGA-3' (SEQ ID NO:1).
6. The method of claim 1, wherein the individual is a mammal.
7. The method of claim 1, wherein administration is at a site of exposure.
8. The method of claim 7, wherein the site of exposure is respiratory mucosa.
9. The method of claim 7, wherein the site of exposure is the nasal passages.
10. The method of claim 1, wherein the suppression comprises a reduction of RSV
titer in a biological sample from said individual.
11. A kit for use in suppressing a respiratory syncytial virus (RSV) infection in an individual infected with or exposed to RSV, comprising:

a composition comprising a polynucleotide comprising an immunostimulatory sequence (ISS), wherein the ISS comprises the sequence 5'-C, G-3' and wherein said kit does not comprises an RSV antigen; and instructions for administration of said composition to an individual infected with or exposed to RSV to suppress RSV infection.
12. The kit of claim 11, wherein the ISS comprises the sequence 5'-T, C, G-3'.
13. The kit of claim 11, wherein the ISS comprises the sequence 5'-purine, purine, C, G, pyrimidine, pyrimidine, G, G-3' or 5'-purine, purine, C, G, pyrimidine, pyrimidine, C, C-3' .
14. The kit of claim 13, wherein the ISS comprises a sequence selected from the group consisting of 5'-AACGTTCC-3', 5'-AACGTTCG-3', 5'-GACGTTCC-3' and 5'-GACGTTCG-3' .
15. The kit of claim 11, wherein the ISS comprises the sequence 5'-TGACTGTGAACGTTCGAGATGA-3' (SEQ ID NO:1).
CA2402268A 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections Expired - Fee Related CA2402268C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18858300P 2000-03-10 2000-03-10
US60/188,583 2000-03-10
US09/802,686 2001-03-09
US09/802,686 US20010046967A1 (en) 2000-03-10 2001-03-09 Methods of preventing and treating respiratory viral infection using immunomodulatory polynucleotide
PCT/US2001/007839 WO2001068116A2 (en) 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections

Publications (2)

Publication Number Publication Date
CA2402268A1 true CA2402268A1 (en) 2001-09-20
CA2402268C CA2402268C (en) 2012-10-02

Family

ID=26884244

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2402268A Expired - Fee Related CA2402268C (en) 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections

Country Status (8)

Country Link
US (3) US20010046967A1 (en)
EP (1) EP1261352B1 (en)
JP (1) JP2003526672A (en)
AT (1) ATE476983T1 (en)
AU (2) AU4358701A (en)
CA (1) CA2402268C (en)
DE (1) DE60142775D1 (en)
WO (1) WO2001068116A2 (en)

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Publication number Publication date
AU4358701A (en) 2001-09-24
JP2003526672A (en) 2003-09-09
EP1261352B1 (en) 2010-08-11
AU2001243587C1 (en) 2006-11-16
AU2001243587B2 (en) 2005-11-24
US20040009942A1 (en) 2004-01-15
WO2001068116A2 (en) 2001-09-20
CA2402268C (en) 2012-10-02
EP1261352A2 (en) 2002-12-04
ATE476983T1 (en) 2010-08-15
US20010046967A1 (en) 2001-11-29
DE60142775D1 (en) 2010-09-23
US20100035975A1 (en) 2010-02-11
US8226957B2 (en) 2012-07-24
WO2001068116A3 (en) 2002-08-08

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