CA2410561A1 - Applicator having abrading surface coated with substance to be applied to skin - Google Patents
Applicator having abrading surface coated with substance to be applied to skin Download PDFInfo
- Publication number
- CA2410561A1 CA2410561A1 CA002410561A CA2410561A CA2410561A1 CA 2410561 A1 CA2410561 A1 CA 2410561A1 CA 002410561 A CA002410561 A CA 002410561A CA 2410561 A CA2410561 A CA 2410561A CA 2410561 A1 CA2410561 A1 CA 2410561A1
- Authority
- CA
- Canada
- Prior art keywords
- skin
- substance
- applicator
- delivery
- surface coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Polishing Bodies And Polishing Tools (AREA)
Abstract
The present invention provides improved methods for delivery of substances into the skin. It has been discovered that delivery of substances such as nucleic acids, amino acids, amino acid derivatives, peptides and polypeptides simultaneously with abrasion of the skin enhances delivery and the biological response as compared to application of the substance to previously abraded skin.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/576,643 US6595947B1 (en) | 2000-05-22 | 2000-05-22 | Topical delivery of vaccines |
US09/576,643 | 2000-05-22 | ||
PCT/US2001/016121 WO2001089622A1 (en) | 2000-05-22 | 2001-05-18 | Applicator having abrading surface coated with substance to be applied to skin |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2410561A1 true CA2410561A1 (en) | 2001-11-29 |
CA2410561C CA2410561C (en) | 2009-05-12 |
Family
ID=24305324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002410561A Expired - Lifetime CA2410561C (en) | 2000-05-22 | 2001-05-18 | Applicator having abrading surface coated with substance to be applied to skin |
Country Status (12)
Country | Link |
---|---|
US (3) | US6595947B1 (en) |
EP (1) | EP1289599B1 (en) |
JP (1) | JP4801309B2 (en) |
CN (1) | CN100394995C (en) |
AT (1) | ATE272423T1 (en) |
AU (2) | AU6175701A (en) |
BR (1) | BR0111345B1 (en) |
CA (1) | CA2410561C (en) |
DE (1) | DE60104686T2 (en) |
ES (1) | ES2222376T3 (en) |
MX (1) | MXPA02011557A (en) |
WO (1) | WO2001089622A1 (en) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9302903B2 (en) * | 2000-12-14 | 2016-04-05 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
US6743215B2 (en) * | 2001-04-06 | 2004-06-01 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and cellulite reduction |
WO2003103570A2 (en) * | 2001-08-01 | 2003-12-18 | University Of Rochester | Transcutaneous immunization against papillomavirus with papillomavirus virus-like particles |
FR2828648A1 (en) * | 2001-08-16 | 2003-02-21 | Adam Bouaziz | CONSTITUTION OF AN EXTRACTIBLE VACCINE FROM AN IMMUNOGENIC INSERT. |
US20040120964A1 (en) * | 2001-10-29 | 2004-06-24 | Mikszta John A. | Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses |
US6908453B2 (en) * | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
KR20120087197A (en) | 2002-07-19 | 2012-08-06 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | Microneedle device, method of using microneedle device and method of delivering microneedle device |
AR040819A1 (en) * | 2002-08-08 | 2005-04-20 | Alza Corp | VACCINE TRANSDERMAL ADMINISTRATION DEVICE THAT HAS MICROPROJECTIONS COVERED |
CA2497154C (en) * | 2002-08-29 | 2012-01-03 | Becton, Dickinson And Company | Substance delivery via a rotating microabrading surface |
BR0314111A (en) * | 2002-09-12 | 2005-07-26 | Childrens Hosp Medical Center | Method and device for painless medication injection |
ATE503491T1 (en) * | 2003-02-13 | 2011-04-15 | Becton Dickinson Co | IMPROVED ANTHRAX VACCINES AND DELIVERY METHODS |
US8961477B2 (en) * | 2003-08-25 | 2015-02-24 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
US20050095283A1 (en) * | 2003-09-16 | 2005-05-05 | Aphios Corporation | Compositions and methods for topically treating diseases |
AU2004287411A1 (en) * | 2003-10-31 | 2005-05-19 | Alza Corporation | System and method for transdermal vaccine delivery |
EP1706171A1 (en) * | 2003-12-29 | 2006-10-04 | 3M Innovative Properties Company | Medical devices and kits including same |
US7896841B2 (en) * | 2004-02-17 | 2011-03-01 | Children's Hospital Medical Center | Injection device for administering a vaccine |
JP2007523771A (en) * | 2004-02-23 | 2007-08-23 | スリーエム イノベイティブ プロパティズ カンパニー | Microneedle array molding method |
WO2005099751A2 (en) * | 2004-04-01 | 2005-10-27 | Alza Corporation | Apparatus and method for transdermal delivery of influenza vaccine |
KR20070011481A (en) * | 2004-04-13 | 2007-01-24 | 알자 코포레이션 | Apparatus and method for transdermal delivery of multiple vaccines |
WO2005123173A1 (en) * | 2004-06-10 | 2005-12-29 | 3M Innovative Properties Company | Patch application device and kit |
EP1768742A4 (en) * | 2004-07-06 | 2007-10-17 | Transpharma Medical Ltd | Delivery system for transdermal immunization |
US7316665B2 (en) * | 2004-08-25 | 2008-01-08 | Becton, Dickinson And Company | Method and device for the delivery of a substance including a covering |
US9174035B2 (en) | 2004-11-18 | 2015-11-03 | 3M Innovative Properties Company | Microneedle array applicator and retainer |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
BRPI0517749A (en) | 2004-11-18 | 2008-10-21 | 3M Innovative Properties Co | application device for applying a micro-needle device to a skin surface, and method for using an application device |
KR101224257B1 (en) * | 2004-11-18 | 2013-01-18 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | Masking method for coating a microneedle array |
JP5015787B2 (en) | 2004-11-18 | 2012-08-29 | スリーエム イノベイティブ プロパティズ カンパニー | Contact coating method of microneedle array |
AU2005314151B2 (en) | 2004-12-07 | 2011-09-08 | 3M Innovative Properties Company | Method of molding a microneedle |
WO2006108185A1 (en) | 2005-04-07 | 2006-10-12 | 3M Innovative Properties Company | System and method for tool feedback sensing |
US20080009802A1 (en) * | 2005-04-25 | 2008-01-10 | Danilo Lambino | Method of treating acne with stratum corneum piercing device |
US20070270738A1 (en) * | 2005-04-25 | 2007-11-22 | Wu Jeffrey M | Method of treating ACNE with stratum corneum piercing patch |
US20060253078A1 (en) * | 2005-04-25 | 2006-11-09 | Wu Jeffrey M | Method of treating skin disorders with stratum corneum piercing device |
EP1904158B1 (en) * | 2005-06-24 | 2013-07-24 | 3M Innovative Properties Company | Collapsible patch with microneedle array |
ATE477833T1 (en) * | 2005-06-27 | 2010-09-15 | 3M Innovative Properties Co | MICRONEEDLE CARTRIDGE ASSEMBLY |
JP5144510B2 (en) | 2005-06-27 | 2013-02-13 | スリーエム イノベイティブ プロパティズ カンパニー | Microneedle array application device |
US20070009542A1 (en) * | 2005-07-05 | 2007-01-11 | Galit Levin | Method and device for transdermal immunization |
CN101242869B (en) | 2005-09-02 | 2010-05-26 | Iomai公司 | Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof |
WO2007061964A1 (en) * | 2005-11-18 | 2007-05-31 | 3M Innovative Properties Company | Methods for coating microneedles |
US20080262416A1 (en) * | 2005-11-18 | 2008-10-23 | Duan Daniel C | Microneedle Arrays and Methods of Preparing Same |
WO2007075614A1 (en) * | 2005-12-21 | 2007-07-05 | 3M Innovative Properties Company | Microneedle devices |
US9339641B2 (en) | 2006-01-17 | 2016-05-17 | Emkinetics, Inc. | Method and apparatus for transdermal stimulation over the palmar and plantar surfaces |
US9610459B2 (en) | 2009-07-24 | 2017-04-04 | Emkinetics, Inc. | Cooling systems and methods for conductive coils |
WO2007124411A1 (en) * | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
US11224742B2 (en) | 2006-10-02 | 2022-01-18 | Emkinetics, Inc. | Methods and devices for performing electrical stimulation to treat various conditions |
US9005102B2 (en) | 2006-10-02 | 2015-04-14 | Emkinetics, Inc. | Method and apparatus for electrical stimulation therapy |
JP2010505471A (en) | 2006-10-02 | 2010-02-25 | エムキネティクス, インコーポレイテッド | Method and apparatus for magnetic induction therapy |
US10786669B2 (en) | 2006-10-02 | 2020-09-29 | Emkinetics, Inc. | Method and apparatus for transdermal stimulation over the palmar and plantar surfaces |
US20090054333A1 (en) * | 2006-10-17 | 2009-02-26 | Antonio Giordano | Peptide inhibitors of cyclin-dependent kinase activity and uses thereof |
US20080214987A1 (en) * | 2006-12-22 | 2008-09-04 | Nanomed Devices, Inc. | Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances |
US8795197B2 (en) * | 2007-07-17 | 2014-08-05 | Histologics, LLC | Frictional trans-epithelial tissue disruption collection apparatus and method of inducing an immune response |
KR20100105829A (en) | 2007-07-17 | 2010-09-30 | 히스톨로직스 엘엘씨 | Frictional trans-epithelial tissue disruption and collection apparatus and method of inducing and/or augmenting an immune response |
WO2009047774A2 (en) * | 2007-10-09 | 2009-04-16 | Transpharma Ltd. | Magnetic patch coupling |
KR101287351B1 (en) | 2007-12-05 | 2013-07-23 | 시네론 메디컬 리미티드 | A carrier for use in a skin treatment apparatus |
EP2561819B1 (en) | 2008-01-17 | 2015-01-07 | Syneron Medical Ltd. | Hair removal apparatus for personal use |
WO2009093230A2 (en) | 2008-01-24 | 2009-07-30 | Syneron Medical Ltd. | A device, apparatus, and method of adipose tissue treatment |
WO2010032235A1 (en) | 2008-09-21 | 2010-03-25 | Syneron Medical Ltd. | A method and apparatus for personal skin treatment |
US8691502B2 (en) | 2008-10-31 | 2014-04-08 | Tremrx, Inc. | T-cell vaccination with viral vectors via mechanical epidermal disruption |
US8606366B2 (en) | 2009-02-18 | 2013-12-10 | Syneron Medical Ltd. | Skin treatment apparatus for personal use and method for using same |
US8834423B2 (en) | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
EP2493551A4 (en) | 2009-10-26 | 2013-04-17 | Emkinetics Inc | Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues |
US9044213B1 (en) | 2010-03-26 | 2015-06-02 | Histologics, LLC | Frictional tissue sampling and collection method and device |
GB201007207D0 (en) | 2010-04-29 | 2010-06-16 | Univ Cork | Method |
US8588884B2 (en) | 2010-05-28 | 2013-11-19 | Emkinetics, Inc. | Microneedle electrode |
CN112933391A (en) | 2012-05-01 | 2021-06-11 | 高等教育联邦系统-匹兹堡大学 | Tip-loaded microneedle array for percutaneous insertion |
US10201332B1 (en) | 2012-12-03 | 2019-02-12 | Healoe Llc | Device and method of orienting a biopsy device on epithelial tissue |
US20140297784A1 (en) * | 2013-03-29 | 2014-10-02 | Lucy Ma Zhao | Cross Platform Application Transactions |
MX2016009771A (en) * | 2014-01-31 | 2016-11-14 | Factor Bioscience Inc | Methods and products for nucleic acid production and delivery. |
JP7199809B2 (en) | 2015-02-13 | 2023-01-06 | ファクター バイオサイエンス インコーポレイテッド | Nucleic acid product and its administration method |
WO2016149673A1 (en) | 2015-03-18 | 2016-09-22 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
US11684763B2 (en) | 2015-10-16 | 2023-06-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices |
US11744889B2 (en) | 2016-01-05 | 2023-09-05 | University of Pittsburgh—of the Commonwealth System of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
US11013466B2 (en) | 2016-01-28 | 2021-05-25 | Healoe, Llc | Device and method to control and manipulate a catheter |
WO2018035377A1 (en) | 2016-08-17 | 2018-02-22 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
CN110582245B (en) | 2017-03-27 | 2022-09-16 | 诺服塞尔有限公司 | Systems, devices, and methods for intradermal solution delivery |
DE102017126501A1 (en) | 2017-11-10 | 2019-05-16 | Lts Lohmann Therapie-Systeme Ag | Micro needle system for the application of a hepatitis vaccine |
US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
Family Cites Families (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3289670A (en) * | 1964-03-09 | 1966-12-06 | Milo Bundy Corp | Device for abrading and applying biologicals to the skin of a patient |
US3351059A (en) * | 1964-06-02 | 1967-11-07 | Norman Lettvin | Single stable dose vaccinator |
US3556080A (en) * | 1968-04-08 | 1971-01-19 | Lincoln Lab Inc | Skin allergy testing device |
US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US4270548A (en) * | 1979-09-05 | 1981-06-02 | Aller-Screen, Inc. | Allergy testing method |
US4483348A (en) | 1982-03-25 | 1984-11-20 | Nathan Sher | Skin testing device |
GB2125280B (en) | 1982-08-18 | 1986-01-02 | Hyman Goldberg | Surgical scrubbing device |
US4568343A (en) * | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
US4746515A (en) * | 1987-02-26 | 1988-05-24 | Alza Corporation | Skin permeation enhancer compositions using glycerol monolaurate |
AU614092B2 (en) | 1987-09-11 | 1991-08-22 | Paul Max Grinwald | Improved method and apparatus for enhanced drug permeation of skin |
CA2008262A1 (en) * | 1989-01-30 | 1990-07-30 | John A. Gilly | Clinical applicator |
EP0429842B1 (en) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
SU1724181A1 (en) | 1990-03-22 | 1992-04-07 | Ивано-Франковский Государственный Медицинский Институт | Tester for chamber-scarification skin testing |
TW279133B (en) * | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
DE4117900A1 (en) | 1991-05-31 | 1992-12-03 | Spantec Werkzeugtechnik Gmbh | ROLL MILLING |
US5620896A (en) * | 1992-03-23 | 1997-04-15 | University Of Massachusetts Medical Center | DNA vaccines against rotavirus infections |
US5273528A (en) * | 1992-07-10 | 1993-12-28 | Skeen Mikell L | Livestock inoculator |
DE4307869C2 (en) * | 1993-03-12 | 1996-04-04 | Microparts Gmbh | Microstructure body and process for its manufacture |
US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
US5885211A (en) * | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
US5380337A (en) * | 1994-01-24 | 1995-01-10 | Romaine; Richard A. | Mesh-type skin biopsy appliance |
US5660680A (en) | 1994-03-07 | 1997-08-26 | The Regents Of The University Of California | Method for fabrication of high vertical aspect ratio thin film structures |
JP2551742B2 (en) * | 1994-05-23 | 1996-11-06 | 三星電機株式会社 | Skin wound forming device for drug administration |
CA2149836C (en) | 1994-05-23 | 1999-07-06 | Sang Bae Choi | Perforating device for dermal administration |
US5591139A (en) * | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
AU3487095A (en) | 1994-09-05 | 1996-03-27 | Cyanamid Websters Pty. Limited | Scratch vaccine applicator and/or method of applying a vacine |
WO1996037256A1 (en) * | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical patch for enhancing the delivery of compounds through the skin |
AU5740496A (en) | 1995-05-22 | 1996-12-11 | General Hospital Corporation, The | Micromechanical device and method for enhancing delivery of compounds through the skin |
JPH0910307A (en) * | 1995-06-30 | 1997-01-14 | Pentel Kk | Injection syringe holder |
US5958589A (en) | 1995-07-07 | 1999-09-28 | The United States Of America As Represented By The Secretary Of Agriculture | Starch-based microcellular foams |
DE19525607A1 (en) | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneal drug delivery system |
US5658515A (en) * | 1995-09-25 | 1997-08-19 | Lee; Abraham P. | Polymer micromold and fabrication process |
GB9520209D0 (en) | 1995-09-25 | 1995-12-06 | Cawley R | Skin cleaning apparatus |
US6032060A (en) * | 1996-01-25 | 2000-02-29 | 3M Innovative Properties Company | Method for conditioning skin and an electrode by passing electrical energy |
AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
US6230051B1 (en) | 1996-06-18 | 2001-05-08 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
US5919364A (en) * | 1996-06-24 | 1999-07-06 | Regents Of The University Of California | Microfabricated filter and shell constructed with a permeable membrane |
DE69722414T2 (en) | 1996-07-03 | 2004-05-19 | Altea Therapeutics Corp. | MULTIPLE MECHANICAL MICROPERFORATION OF SKIN OR MUCOSA |
US5983136A (en) | 1996-09-17 | 1999-11-09 | Deka Products Limited Partnership | System for delivery of drugs by transport |
US5910306A (en) * | 1996-11-14 | 1999-06-08 | The United States Of America As Represented By The Secretary Of The Army | Transdermal delivery system for antigen |
US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
US6065864A (en) | 1997-01-24 | 2000-05-23 | The Regents Of The University Of California | Apparatus and method for planar laminar mixing |
US5928207A (en) | 1997-06-30 | 1999-07-27 | The Regents Of The University Of California | Microneedle with isotropically etched tip, and method of fabricating such a device |
US5931794A (en) | 1997-10-21 | 1999-08-03 | Pitesky; Isadore | Allergy testing apparatus |
IL122016A (en) * | 1997-10-22 | 2001-09-13 | Tav Tech Ltd | Apparatus for dermal abrasion |
ATE221400T1 (en) * | 1997-12-11 | 2002-08-15 | Alza Corp | DEVICE FOR INCREASE THE TRANSDERMAL FLOW OF ACTIVE INGREDIENTS |
JP4875799B2 (en) | 1998-02-25 | 2012-02-15 | アメリカ合衆国 | Use of skin permeation enhancers and barrier disintegrants to promote transdermal immune responses attracted by ADP-ribosylated exotoxins |
US5970998A (en) | 1998-02-27 | 1999-10-26 | The Regents Of The University Of California | Microfabricated cantilever ratchet valve, and method for using same |
US6173202B1 (en) | 1998-03-06 | 2001-01-09 | Spectrx, Inc. | Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue |
US6106751A (en) | 1998-03-18 | 2000-08-22 | The Regents Of The University Of California | Method for fabricating needles via conformal deposition in two-piece molds |
US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6623457B1 (en) * | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
US6835184B1 (en) * | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
US6331266B1 (en) * | 1999-09-29 | 2001-12-18 | Becton Dickinson And Company | Process of making a molded device |
US6494865B1 (en) * | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
ATE295200T1 (en) * | 1999-12-10 | 2005-05-15 | Alza Corp | SKIN TREATMENT DEVICE FOR PROLONGED TRANSDERMAL ADMINISTRATION OF MEDICATIONS |
-
2000
- 2000-05-22 US US09/576,643 patent/US6595947B1/en not_active Expired - Lifetime
-
2001
- 2001-05-18 MX MXPA02011557A patent/MXPA02011557A/en active IP Right Grant
- 2001-05-18 DE DE60104686T patent/DE60104686T2/en not_active Expired - Lifetime
- 2001-05-18 WO PCT/US2001/016121 patent/WO2001089622A1/en active IP Right Grant
- 2001-05-18 AU AU6175701A patent/AU6175701A/en active Pending
- 2001-05-18 JP JP2001585860A patent/JP4801309B2/en not_active Expired - Fee Related
- 2001-05-18 BR BRPI0111345-3A patent/BR0111345B1/en not_active IP Right Cessation
- 2001-05-18 AT AT01935686T patent/ATE272423T1/en not_active IP Right Cessation
- 2001-05-18 CA CA002410561A patent/CA2410561C/en not_active Expired - Lifetime
- 2001-05-18 ES ES01935686T patent/ES2222376T3/en not_active Expired - Lifetime
- 2001-05-18 CN CNB018099157A patent/CN100394995C/en not_active Expired - Fee Related
- 2001-05-18 AU AU2001261757A patent/AU2001261757B2/en not_active Ceased
- 2001-05-18 EP EP01935686A patent/EP1289599B1/en not_active Expired - Lifetime
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2003
- 2003-05-13 US US10/436,757 patent/US20030191085A1/en not_active Abandoned
-
2007
- 2007-09-07 US US11/851,956 patent/US7731968B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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MXPA02011557A (en) | 2004-09-06 |
CN1430526A (en) | 2003-07-16 |
AU2001261757B2 (en) | 2004-04-01 |
US6595947B1 (en) | 2003-07-22 |
US20030191085A1 (en) | 2003-10-09 |
BR0111345B1 (en) | 2010-10-05 |
CN100394995C (en) | 2008-06-18 |
EP1289599B1 (en) | 2004-08-04 |
DE60104686D1 (en) | 2004-09-09 |
BR0111345A (en) | 2004-02-03 |
JP4801309B2 (en) | 2011-10-26 |
JP2003534065A (en) | 2003-11-18 |
US20080009785A1 (en) | 2008-01-10 |
ES2222376T3 (en) | 2005-02-01 |
ATE272423T1 (en) | 2004-08-15 |
WO2001089622A1 (en) | 2001-11-29 |
AU6175701A (en) | 2001-12-03 |
EP1289599A1 (en) | 2003-03-12 |
DE60104686T2 (en) | 2005-08-11 |
US7731968B2 (en) | 2010-06-08 |
CA2410561C (en) | 2009-05-12 |
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