CA2419213A1 - Improved electrical sensor - Google Patents

Improved electrical sensor Download PDF

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Publication number
CA2419213A1
CA2419213A1 CA002419213A CA2419213A CA2419213A1 CA 2419213 A1 CA2419213 A1 CA 2419213A1 CA 002419213 A CA002419213 A CA 002419213A CA 2419213 A CA2419213 A CA 2419213A CA 2419213 A1 CA2419213 A1 CA 2419213A1
Authority
CA
Canada
Prior art keywords
sensor
counter electrode
sub
electrode
working
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002419213A
Other languages
French (fr)
Other versions
CA2419213C (en
Inventor
Andrew J. Edelbrock
Matthew K. Musho
Mark S. Vreeke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Healthcare LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27757795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2419213(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2419213A1 publication Critical patent/CA2419213A1/en
Application granted granted Critical
Publication of CA2419213C publication Critical patent/CA2419213C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/201—Glucose concentration

Abstract

Disclosed is an electrochemical sensor for the determina-tion of analytes in body fluids, e.g. glucose in blood. The sensor involves a non-conductive base which provides a flow path for the body fluid with the base having a working and counter electrode on its surface which are in electrical com-munication with a detector of current. The base and a cover therefore provide a capillary space containing the electrodes into which the body fluid is drawn by capillary action. The counter electrode has a sub-element which contains an electro-active material and is configured in the system (sensor and meter) to provide an error signal when insufficient body fluid is drawn into the capillary.

Claims (10)

1. In an electrochemical sensor for determining the concen-tration of an analyte in a fluid test sample comprising 1) a non-conductive base which provides a flow path for the fluid test sample and has a counter electrode and a working elec-trode on its upper surface which are in electrical communica-tion with a detector of electrical current; 2) a reaction layer on the upper surface of the working electrode comprising an enzyme and mediator which reacts with the analyte to cause electrons to be transferred between the analyte and the work-ing electrode; and 3) a cover which when mated with the base forms a capillary space with an opening for the introduction of fluid test sample thereto which space contains the flow path for the fluid test sample in which the working and coun-ter electrodes are situated so that the major portion of the counter electrode is located downstream of the opening from the working electrode, with a sub-element of the counter elec-trode being upstream from the working electrode, so that when electrical communication between only the sub-element of the counter electrode and the working electrode takes place, there is insufficient flow of electrical current through the detec-tor to constitute a valid test upon the application of between the working electrode and the sub-element, the improvement which comprises employing a sub-element of the counter elec-trode which comprises an electroactive material capable of al-lowing oxidation to occur at the surface of the working elec-trode under the applied potential and is present in an amount which is insufficient to maintain the flow of electric current through the detector to constitute a valid determination of analyte concentration.
2. The sensor of Claim 1 which comprises an insulating base, an electrical conductor pattern, an electrode pattern compris-ing a working electrode and a counter electrode, a sub-element of the counter electrode, an insulating layer partially cover-ing the electrodes, and a reaction layer.
3. The sensor of Claim 2 wherein the reaction layer com-prises poly(ethylene oxide), an enzyme and a ferricyanide salt.
4. The sensor of Claim 3 wherein the enzyme is glucose oxi-dase.
5. The sensor of Claim 1 wherein the electroactive material is an oxide of Ag, Cu, Mn, Pb, Hg, Ni, Co, Bi, Re, or Te.
6. The sensor of Claim 1 wherein the electroactive material is AgO.
7. The sensor of Claim 1 wherein silver has been deposited on the surface of the sub-element of the counter electrode and oxidized in place to form silver oxide.
8. The sensor of Claim 1 wherein the electroactive material is a metal halide.
9. The sensor of Claim 1 wherein the sub-element of the counter electrode is physically disconnected from the main body of the counter electrode and provided with its own con-nection to the detector through the main body of the counter electrode.
10. The sensor of Claim 2 wherein there is no reagent in con-tact with the sub-element of the counter electrode.
CA2419213A 2002-03-07 2003-02-19 Improved electrical sensor Expired - Lifetime CA2419213C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36338002P 2002-03-07 2002-03-07
US60/363,380 2002-03-07

Publications (2)

Publication Number Publication Date
CA2419213A1 true CA2419213A1 (en) 2003-09-07
CA2419213C CA2419213C (en) 2011-06-21

Family

ID=27757795

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2419213A Expired - Lifetime CA2419213C (en) 2002-03-07 2003-02-19 Improved electrical sensor

Country Status (7)

Country Link
US (2) US20040007461A1 (en)
EP (1) EP1343007B1 (en)
JP (1) JP3999148B2 (en)
AU (1) AU2003200788B2 (en)
CA (1) CA2419213C (en)
DK (1) DK1343007T3 (en)
ES (1) ES2399092T3 (en)

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USRE44521E1 (en) 1999-08-02 2013-10-08 Bayer Healthcare Llc Electrochemical-sensor design
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Also Published As

Publication number Publication date
EP1343007A1 (en) 2003-09-10
CA2419213C (en) 2011-06-21
JP2003279526A (en) 2003-10-02
US7118668B1 (en) 2006-10-10
JP3999148B2 (en) 2007-10-31
US20060219551A1 (en) 2006-10-05
EP1343007B1 (en) 2013-01-09
US20040007461A1 (en) 2004-01-15
ES2399092T3 (en) 2013-03-25
AU2003200788B2 (en) 2010-12-02
DK1343007T3 (en) 2013-04-15
AU2003200788A1 (en) 2003-09-25

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