CA2427837A1 - Radioactive member for use in brachytherapy and method of making - Google Patents
Radioactive member for use in brachytherapy and method of making Download PDFInfo
- Publication number
- CA2427837A1 CA2427837A1 CA002427837A CA2427837A CA2427837A1 CA 2427837 A1 CA2427837 A1 CA 2427837A1 CA 002427837 A CA002427837 A CA 002427837A CA 2427837 A CA2427837 A CA 2427837A CA 2427837 A1 CA2427837 A1 CA 2427837A1
- Authority
- CA
- Canada
- Prior art keywords
- radioactive
- bioabsorbable carrier
- elongate
- mold
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1027—Interstitial radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1023—Means for creating a row of seeds, e.g. spacers
Abstract
A radioactive member for use in brachytherapy comprising a molded elongate, bioabsorbable carrier material with spaced radioactive sources disposed therein, and methods for the manufacture thereof. The radioactive members may be used in treatment of, for example, prostate cancer.
Claims (24)
1. ~A radioactive member for use in brachytherapy comprising an elongate bioabsorbable carrier molded about spaced radioactive sources disposed therein.
2. ~A radioactive member as claimed in claim 1 wherein said elongate bioabsorbable carrier is essentially rigid.
3. ~A radioactive member as claimed in claim 2 wherein said elongate bioabsorbable carrier is formed from a material selected from the group consisting of poly(-L-lactic acid), poly(glycolic acid), polyester amides of glycolic acids, polyester amides of lactic acids, and combinations thereof.
4. ~A radioactive member as claimed in claim 3 wherein said elongate bioabsorbable carrier comprises a combination of PLLA (Poly (L-lactide)) and PGA (Poly (glycolide)) having 10 parts PLLA/90 parts PGA w/w.
5. ~A radioactive member as claimed in claim 4 wherein said elongate bioabsorbable carrier forms regions containing radioactive sources and regions devoid of radioactive sources.
6. ~A radioactive member as claimed in claim 5, wherein said regions of said elongate bioabsorbable carrier containing radioactive sources are wider than said regions devoid of radioactive sources.
7. ~A radioactive member as claimed in claim 1, wherein said elongate bioabsorbable carrier is echogenic.
8.~A radioactive member as claimed in claim 1, wherein said radioactive sources are radioactive seeds.
9. ~A radioactive member as claimed in claim 1, wherein said elongate bioabsorbable carrier comprises a porous structure.
10. ~A radioactive member for use in brachytherapy comprising an elongate bioabsorbable carrier with spaced radioactive sources disposed therein, wherein said elongate bioabsorbable carrier is of a substantially solid composition.
11. ~A radioactive member as claimed in claim 10, wherein said elongate bioabsorbable carrier is essentially rigid.
12. ~A radioactive member as claimed in claim 11, wherein said elongate bioabsorbable carrier is formed from a material selected from the group consisting of poly(-L-lactic acid), poly(glycolic acid), polyester amides of glycolic acids, polyester amides of lactic acids, and combinations thereof.
13. ~A radioactive member as claimed in claim 12, wherein said elongate bioabsorbable carrier comprises a combination of PLLA (Poly (L-lactide)) and PGA (Poly (glycolide)) having 10 parts PLLA/90 parts PGA w/w.
14. ~A radioactive member as claimed in claim 13, wherein said elongate bioabsorbable carrier forms regions containing radioactive sources and regions devoid of radioactive sources.
15. ~A radioactive member as claimed in claim 14, wherein said regions of said elongate bioabsorbable carrier containing radioactive sources are wider than said regions devoid of radioactive sources.
16. ~A radioactive member as claimed in claim 10, wherein said elongate bioabsorbable carrier is echogenic.
17. ~A method for making a radioactive member comprising the steps of:
a) providing a mold;
b) introducing a plurality of radioactive sources into the mold;
c) introducing liquid bioabsorbable carrier material into the mold;
d) setting the liquid bioabsorbable carrier material; and e) removing the set product from the mold.
a) providing a mold;
b) introducing a plurality of radioactive sources into the mold;
c) introducing liquid bioabsorbable carrier material into the mold;
d) setting the liquid bioabsorbable carrier material; and e) removing the set product from the mold.
18. ~A method as claimed in claim 17, wherein said introducing step further comprises injecting said material into said mold.
19. A method as claimed in claim 18, wherein the mold has a number of small pins protruding towards its centre position so as to hold radioactive sources at predetermined positions in the mold prior to the introduction of the liquid bioabsorbable carrier material.
20. A method as claimed in claim 17, further comprising the step of introducing a blowing agent into said carrier material.
21. A method as claimed in claim 17, further comprising the step of venting entrapped air from said mold during said step of introducing liquid bioabsorbable carrier material into the mold.
22. A method as claimed in claim 17, wherein said setting step further comprising~
forming gas bubbles in said carrier material so as to form a porous structure to the set carrier material.
forming gas bubbles in said carrier material so as to form a porous structure to the set carrier material.
23. A method of treatment of a condition which is responsive to radiation therapy which comprises the step of placing a radioactive member as claimed in claim 1 adjacent a site to be treated within a patient for a sufficient period of time to deliver a therapeutically effective dose.
24. A method as claimed in claim 23 wherein the condition is cancer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24504600P | 2000-11-01 | 2000-11-01 | |
| US60/245,046 | 2000-11-01 | ||
| PCT/US2001/049879 WO2002036199A2 (en) | 2000-11-01 | 2001-11-01 | Radioactive member for use in brachytherapy and method of making |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2427837A1 true CA2427837A1 (en) | 2002-05-10 |
| CA2427837C CA2427837C (en) | 2010-07-13 |
Family
ID=22925077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2427837A Expired - Fee Related CA2427837C (en) | 2000-11-01 | 2001-11-01 | Radioactive member for use in brachytherapy and method of making |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6905455B2 (en) |
| EP (1) | EP1330292B1 (en) |
| AT (1) | ATE305809T1 (en) |
| AU (5) | AU3122702A (en) |
| BR (1) | BR0115087B1 (en) |
| CA (1) | CA2427837C (en) |
| CZ (1) | CZ20031217A3 (en) |
| DE (1) | DE60113871T2 (en) |
| DK (1) | DK1330292T3 (en) |
| ES (1) | ES2253446T3 (en) |
| IL (1) | IL155382A0 (en) |
| MX (1) | MXPA03003852A (en) |
| NO (1) | NO20031803L (en) |
| NZ (2) | NZ525361A (en) |
| PL (1) | PL203978B1 (en) |
| RU (1) | RU2277953C2 (en) |
| WO (1) | WO2002036199A2 (en) |
| ZA (1) | ZA200303372B (en) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
| US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
| US6949064B2 (en) | 2000-10-20 | 2005-09-27 | Bard Brachytherapy, Inc. | Brachytherapy seed deployment system |
| EP1545705A4 (en) | 2000-11-16 | 2010-04-28 | Microspherix Llc | Flexible and/or elastic brachytherapy seed or strand |
| EP2428171B1 (en) | 2001-09-24 | 2014-02-19 | Applied Medical Resources Corporation | Bladeless Obturator |
| US6786858B2 (en) * | 2001-11-02 | 2004-09-07 | Ideamatrix, Inc. | Delivery system and method for interstitial radiotherapy using hollow seeds |
| US7094198B2 (en) * | 2001-11-02 | 2006-08-22 | Worldwide Medical Technologies, Llc | Delivery system and method for interstitial radiation therapy using seed elements with ends having one of projections and indentations |
| US7074291B2 (en) * | 2001-11-02 | 2006-07-11 | Worldwide Medical Technologies, L.L.C. | Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings |
| US7060020B2 (en) * | 2001-11-02 | 2006-06-13 | Ideamatrix, Inc. | Delivery system and method for interstitial radiation therapy |
| US6761680B2 (en) | 2001-11-02 | 2004-07-13 | Richard A. Terwilliger | Delivery system and method for interstitial radiation therapy using seed strands constructed with preformed strand housing |
| IL147898A (en) * | 2002-01-30 | 2007-05-15 | Yuval Golan | Auger effect-based cancer therapy method |
| DE10204818C2 (en) * | 2002-02-06 | 2003-11-27 | Eurotope Entwicklungsgesellsch | Device and method for loading implantation needles with radiation sources from radiation source chains for interstitial brachytherapy of tissue |
| JP2005525860A (en) | 2002-05-16 | 2005-09-02 | アプライド メディカル リソーシーズ コーポレイション | An obturator with a conical tip |
| US6932758B1 (en) * | 2003-02-12 | 2005-08-23 | Bruno Schmidt | Coupled seed train |
| US7322928B2 (en) * | 2003-03-17 | 2008-01-29 | Medi-Physics, Inc. | Products and methods for brachytherapy |
| US6997862B2 (en) * | 2003-05-13 | 2006-02-14 | Ideamatrix, Inc. | Delivery system and method for interstitial radiation therapy using seed strands with custom end spacing |
| EP2545860B1 (en) | 2003-10-03 | 2014-02-12 | Applied Medical Resources Corporation | Bladeless optical obturator |
| US20050080314A1 (en) * | 2003-10-09 | 2005-04-14 | Terwilliger Richard A. | Shielded transport for multiple brachytheapy implants with integrated measuring and cutting board |
| EP1765197B1 (en) | 2004-06-29 | 2017-03-29 | Applied Medical Resources Corporation | Insufflating optical surgical instrument |
| EP1681077A1 (en) * | 2005-01-12 | 2006-07-19 | Acrostak Corp. | A positioning device and a procedure for treating the walls of a resection cavity |
| US7736293B2 (en) * | 2005-07-22 | 2010-06-15 | Biocompatibles Uk Limited | Implants for use in brachytherapy and other radiation therapy that resist migration and rotation |
| US8187159B2 (en) | 2005-07-22 | 2012-05-29 | Biocompatibles, UK | Therapeutic member including a rail used in brachytherapy and other radiation therapy |
| US7794644B2 (en) * | 2005-10-05 | 2010-09-14 | Applied Medical Resources Corporation | Thin-walled optical obturator |
| WO2007053823A2 (en) * | 2005-10-31 | 2007-05-10 | Biolucent, Inc. | Brachytherapy apparatus and methods of using same |
| US20070265487A1 (en) * | 2006-05-09 | 2007-11-15 | Worldwide Medical Technologies Llc | Applicators for use in positioning implants for use in brachytherapy and other radiation therapy |
| US7988611B2 (en) | 2006-05-09 | 2011-08-02 | Biocompatibles Uk Limited | After-loader for positioning implants for needle delivery in brachytherapy and other radiation therapy |
| US20090216063A1 (en) * | 2008-01-29 | 2009-08-27 | Biocompatibles Uk Limited | Bio-absorbable brachytherapy strands |
| US20090304576A1 (en) * | 2006-08-08 | 2009-12-10 | Warren Stephen L | Device for delivery of anti-cancer agents to tissue |
| US7878964B1 (en) | 2006-09-07 | 2011-02-01 | Biocompatibles Uk Limited | Echogenic spacers and strands |
| US7874976B1 (en) | 2006-09-07 | 2011-01-25 | Biocompatibles Uk Limited | Echogenic strands and spacers therein |
| US8517977B2 (en) * | 2006-10-06 | 2013-08-27 | Applied Medical Resources Corporation | Visual insufflation port |
| US20080269540A1 (en) * | 2007-04-27 | 2008-10-30 | Worldwide Medical Technologies Llc | Seed cartridge adaptor and methods for use therewith |
| EP2220321A1 (en) * | 2007-11-13 | 2010-08-25 | Infinite Edge Technologies, LLC | Reinforced window spacer |
| US9089707B2 (en) | 2008-07-02 | 2015-07-28 | The Board Of Regents, The University Of Texas System | Systems, methods and devices for paired plasticity |
| US8457757B2 (en) | 2007-11-26 | 2013-06-04 | Micro Transponder, Inc. | Implantable transponder systems and methods |
| DE112008003180T5 (en) * | 2007-11-26 | 2011-03-03 | Micro-Transponder, Inc., Dallas | Implantable transponder systems and methods |
| KR101409458B1 (en) * | 2007-11-28 | 2014-06-19 | 삼성전자주식회사 | Portable communication terminal having an aromatic function and apparatus for charging communication terminal having the same |
| EP2837345B1 (en) * | 2008-01-25 | 2016-10-05 | Applied Medical Resources Corporation | Insufflating access system |
| PL2293914T3 (en) * | 2008-06-30 | 2012-09-28 | Cerebel Invest Sa | Method for moulding poly(1,4-dioxanone) |
| RU2460643C1 (en) * | 2008-06-30 | 2012-09-10 | Серебель-Инвест Са | Method of casting poly-1,4-dioxanone |
| EP2328487B1 (en) | 2008-09-29 | 2018-04-18 | Applied Medical Resources Corporation | First-entry trocar system |
| US9014787B2 (en) | 2009-06-01 | 2015-04-21 | Focal Therapeutics, Inc. | Bioabsorbable target for diagnostic or therapeutic procedure |
| WO2012066498A1 (en) * | 2010-11-18 | 2012-05-24 | Northern Oncology (Pty) Ltd | Brachytherapy seed, methodology and calculating dose of brachytherapy and method of treatment |
| US10350431B2 (en) | 2011-04-28 | 2019-07-16 | Gt Medical Technologies, Inc. | Customizable radioactive carriers and loading system |
| EP3456384B1 (en) | 2011-04-28 | 2020-07-22 | GT Medical Technologies, Inc. | Dosimetrically customizable brachytherapy carriers |
| JP6066428B2 (en) | 2011-05-02 | 2017-01-25 | アプライド メディカル リソーシーズ コーポレイション | Low profile surgical universal access port |
| US20130289389A1 (en) | 2012-04-26 | 2013-10-31 | Focal Therapeutics | Surgical implant for marking soft tissue |
| US9492683B2 (en) | 2013-03-15 | 2016-11-15 | Gammatile Llc | Dosimetrically customizable brachytherapy carriers and methods thereof in the treatment of tumors |
| CN103736200B (en) * | 2013-12-31 | 2016-08-17 | 原子高科股份有限公司 | A kind of preparation method of radioactive particle chain |
| EP3171820B1 (en) | 2014-07-25 | 2022-11-16 | Hologic, Inc. | Implantable devices and techniques for oncoplastic surgery |
| US9821174B1 (en) | 2015-02-06 | 2017-11-21 | Gammatile Llc | Radioactive implant planning system and placement guide system |
| US9403033B1 (en) | 2015-04-24 | 2016-08-02 | Gammatile Llc | Apparatus and method for loading radioactive seeds into carriers |
| WO2016179420A1 (en) | 2015-05-06 | 2016-11-10 | Gammatile Llc | Radiation shielding |
| US10888710B1 (en) | 2016-11-29 | 2021-01-12 | Gt Medical Technologies, Inc. | Transparent loading apparatus |
| US11219502B2 (en) | 2017-09-11 | 2022-01-11 | Medtronic Advanced Energy, Llc | Transformative shape-memory polymer tissue cavity marker devices, systems and deployment methods |
| US11324567B2 (en) | 2018-02-01 | 2022-05-10 | Medtronic Advanced Energy, Llc | Expandable tissue cavity marker devices, systems and deployment methods |
| US10981018B2 (en) | 2019-02-14 | 2021-04-20 | Gt Medical Technologies, Inc. | Radioactive seed loading apparatus |
| CA3211766A1 (en) * | 2021-03-19 | 2022-09-22 | Gt Medical Technologies, Inc. | Custom brachytherapy carriers |
| US20230211176A1 (en) * | 2021-12-30 | 2023-07-06 | Gt Medical Technologies, Inc. | Radiation shielding apparatus for implantable radioactive seeds |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US466681A (en) * | 1892-01-05 | Scrubbing-machine | ||
| US28554A (en) * | 1860-06-05 | Joseph brakeley | ||
| US51136A (en) * | 1865-11-28 | Improvement in tubes and pumps for wells | ||
| US2702316A (en) * | 1951-02-28 | 1955-02-15 | Rca Corp | Signal modulation system |
| US2703316A (en) | 1951-06-05 | 1955-03-01 | Du Pont | Polymers of high melting lactide |
| US2668162A (en) | 1952-03-20 | 1954-02-02 | Du Pont | Preparation of high molecular weight polyhydroxyacetic ester |
| US2758987A (en) | 1952-06-05 | 1956-08-14 | Du Pont | Optically active homopolymers containing but one antipodal species of an alpha-monohydroxy monocarboxylic acid |
| US3297033A (en) | 1963-10-31 | 1967-01-10 | American Cyanamid Co | Surgical sutures |
| US3351049A (en) | 1965-04-12 | 1967-11-07 | Hazleton Nuclear Science Corp | Therapeutic metal seed containing within a radioactive isotope disposed on a carrier and method of manufacture |
| BE758156R (en) | 1970-05-13 | 1971-04-28 | Ethicon Inc | ABSORBABLE SUTURE ELEMENT AND ITS |
| US3839297A (en) | 1971-11-22 | 1974-10-01 | Ethicon Inc | Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures |
| US4052988A (en) | 1976-01-12 | 1977-10-11 | Ethicon, Inc. | Synthetic absorbable surgical devices of poly-dioxanone |
| US4141087A (en) | 1977-01-19 | 1979-02-27 | Ethicon, Inc. | Isomorphic copolyoxalates and sutures thereof |
| US4323055A (en) | 1980-04-08 | 1982-04-06 | Minnesota Mining And Manufacturing Company | Radioactive iodine seed |
| US4689424A (en) | 1981-08-06 | 1987-08-25 | Ethicon, Inc. | Radiation sterilizable absorbable polymeric materials and methods for manufacturing the same |
| US4441496A (en) | 1982-02-08 | 1984-04-10 | Ethicon, Inc. | Copolymers of p-dioxanone and 2,5-morpholinediones and surgical devices formed therefrom having accelerated absorption characteristics |
| US4452973A (en) | 1982-11-12 | 1984-06-05 | American Cyanamid Company | Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same |
| US4510295A (en) | 1983-01-20 | 1985-04-09 | Ethicon, Inc. | Absorbable polymers of substituted benzoic acid |
| US4473670A (en) | 1983-05-25 | 1984-09-25 | Ethicon, Inc. | Salt-filled absorbable polymers |
| US4612923A (en) | 1983-12-01 | 1986-09-23 | Ethicon, Inc. | Glass-filled, absorbable surgical devices |
| US4646741A (en) | 1984-11-09 | 1987-03-03 | Ethicon, Inc. | Surgical fastener made from polymeric blends |
| US4754745A (en) * | 1984-11-21 | 1988-07-05 | Horowitz Bruce S | Conformable sheet material for use in brachytherapy |
| US4697575A (en) | 1984-11-21 | 1987-10-06 | Henry Ford Hospital | Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member |
| US4702228A (en) | 1985-01-24 | 1987-10-27 | Theragenics Corporation | X-ray-emitting interstitial implants |
| US4741337A (en) | 1985-07-17 | 1988-05-03 | Ethicon, Inc. | Surgical fastener made from glycolide-rich polymer blends |
| JPH0641786B2 (en) | 1985-07-31 | 1994-06-01 | アイシン・エィ・ダブリュ株式会社 | Lockup clutch control system for multi-speed automatic transmission. |
| US4916209A (en) | 1987-12-23 | 1990-04-10 | Pfizer Inc. | Bioabsorbable polydepsipeptide, preparation and use thereof |
| AT397468B (en) | 1990-07-11 | 1994-04-25 | Oesterr Forsch Seibersdorf | SPOTLIGHT HOLDER AND METHOD AND DEVICE FOR PRODUCING THE SAME |
| JP2740358B2 (en) | 1991-02-04 | 1998-04-15 | シャープ株式会社 | CAD equipment for pattern design |
| CA2112905A1 (en) | 1991-07-05 | 1993-01-21 | Michael R. Violante | Ultrasmall non-aggregated porous particles entrapping gas-bubbles |
| US5264540A (en) | 1992-07-20 | 1993-11-23 | Ethicon, Inc. | Aromatic polyanhydrides |
| US5450592A (en) * | 1992-09-02 | 1995-09-12 | Data General Corporation | Shared resource control using a deferred operations list |
| US5397816A (en) | 1992-11-17 | 1995-03-14 | Ethicon, Inc. | Reinforced absorbable polymers |
| US5460592A (en) * | 1994-01-24 | 1995-10-24 | Amersham Holdings, Inc. | Apparatus and method for making carrier assembly for radioactive seed carrier |
| CA2150432A1 (en) * | 1995-05-30 | 1996-12-01 | Bert Van Den Berg | Models for computer integrated manufacturing |
| US6589502B1 (en) * | 1995-11-27 | 2003-07-08 | International Brachytherapy S.A. | Radioisotope dispersed in a matrix for brachytherapy |
| US6080099A (en) * | 1998-08-12 | 2000-06-27 | Syntheon, Llc | Radioactive therapeutic seeds |
| IL142166A0 (en) | 1998-11-06 | 2002-03-10 | Nycomed Amersham Plc | Products and methods for brachytherapy |
| JP4349546B2 (en) | 1999-02-25 | 2009-10-21 | ジーイー・ヘルスケア・リミテッド | Medical tools and devices with improved ultrasound visibility |
| EP1173252B1 (en) * | 1999-04-28 | 2007-12-05 | Medi Physics, Inc. | Products for brachytherapy and methods for their production |
-
2001
- 2001-11-01 IL IL15538201A patent/IL155382A0/en unknown
- 2001-11-01 ES ES01991503T patent/ES2253446T3/en not_active Expired - Lifetime
- 2001-11-01 DE DE60113871T patent/DE60113871T2/en not_active Expired - Lifetime
- 2001-11-01 BR BRPI0115087-1A patent/BR0115087B1/en not_active IP Right Cessation
- 2001-11-01 DK DK01991503T patent/DK1330292T3/en active
- 2001-11-01 US US10/415,715 patent/US6905455B2/en not_active Expired - Lifetime
- 2001-11-01 CZ CZ20031217A patent/CZ20031217A3/en unknown
- 2001-11-01 PL PL366252A patent/PL203978B1/en not_active IP Right Cessation
- 2001-11-01 MX MXPA03003852A patent/MXPA03003852A/en active IP Right Grant
- 2001-11-01 WO PCT/US2001/049879 patent/WO2002036199A2/en active IP Right Grant
- 2001-11-01 AU AU3122702A patent/AU3122702A/en active Pending
- 2001-11-01 AU AU2002231227A patent/AU2002231227B2/en not_active Ceased
- 2001-11-01 EP EP01991503A patent/EP1330292B1/en not_active Expired - Lifetime
- 2001-11-01 NZ NZ525361A patent/NZ525361A/en not_active IP Right Cessation
- 2001-11-01 RU RU2003112010/14A patent/RU2277953C2/en not_active IP Right Cessation
- 2001-11-01 CA CA2427837A patent/CA2427837C/en not_active Expired - Fee Related
- 2001-11-01 AT AT01991503T patent/ATE305809T1/en not_active IP Right Cessation
- 2001-11-01 NZ NZ543165A patent/NZ543165A/en not_active IP Right Cessation
-
2003
- 2003-04-23 NO NO20031803A patent/NO20031803L/en not_active Application Discontinuation
- 2003-04-30 ZA ZA200303372A patent/ZA200303372B/en unknown
-
2005
- 2005-04-05 US US11/099,238 patent/US7547274B2/en not_active Expired - Fee Related
-
2007
- 2007-05-23 AU AU2007202344A patent/AU2007202344A1/en not_active Abandoned
- 2007-09-06 AU AU2007216652A patent/AU2007216652B2/en not_active Ceased
-
2009
- 2009-06-15 US US12/484,511 patent/US8033981B2/en not_active Expired - Fee Related
- 2009-10-22 AU AU2009227914A patent/AU2009227914B2/en not_active Ceased
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