CA2427990A1 - Improved cell carrier grids - Google Patents

Improved cell carrier grids Download PDF

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Publication number
CA2427990A1
CA2427990A1 CA002427990A CA2427990A CA2427990A1 CA 2427990 A1 CA2427990 A1 CA 2427990A1 CA 002427990 A CA002427990 A CA 002427990A CA 2427990 A CA2427990 A CA 2427990A CA 2427990 A1 CA2427990 A1 CA 2427990A1
Authority
CA
Canada
Prior art keywords
holes
cell carrier
improved cell
individual
grid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002427990A
Other languages
French (fr)
Other versions
CA2427990C (en
Inventor
Tamir Huberman
Yael Schiffenbauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Kinetics Ltd
Original Assignee
Medis El Ltd.
Tamir Huberman
Yael Schiffenbauer
Cell Kinetics Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medis El Ltd., Tamir Huberman, Yael Schiffenbauer, Cell Kinetics Ltd. filed Critical Medis El Ltd.
Publication of CA2427990A1 publication Critical patent/CA2427990A1/en
Application granted granted Critical
Publication of CA2427990C publication Critical patent/CA2427990C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/26—Inoculator or sampler
    • C12M1/32—Inoculator or sampler multiple field or continuous type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/56—Means for indicating position of a recipient or sample in an array
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum

Abstract

An improved cell carrier grid (20). The grid (20) is capable of containing and retaining individual living cells in an array discrete locations and includes a body (22) that defines having an ordered array (24) of holes (26) is identifiable. Each of said holes (26) can contain at least a portion of an individual living cell. According to some embodiments of the invention, individual cells contained within said holes (26) reside substantially in a single focal plane so that accuracy of data collected is increased. According to some embodiments of the invention, said body (22) is at least partially coated with a biologically active material (58). According to some embodiments of the invention, said body (22) is designed and constructed such that the individual cells contained within said holes (26) are recoverable by a recovery device.
CA002427990A 2000-11-28 2001-10-30 Improved cell carrier grids Expired - Fee Related CA2427990C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25313400P 2000-11-28 2000-11-28
US60/253,134 2000-11-28
PCT/US2001/042844 WO2002044318A1 (en) 2000-11-28 2001-10-30 Improved cell carrier grids

Publications (2)

Publication Number Publication Date
CA2427990A1 true CA2427990A1 (en) 2002-06-06
CA2427990C CA2427990C (en) 2009-03-17

Family

ID=22959012

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002427990A Expired - Fee Related CA2427990C (en) 2000-11-28 2001-10-30 Improved cell carrier grids

Country Status (8)

Country Link
US (1) US6495340B2 (en)
EP (1) EP1337622A4 (en)
JP (1) JP3940361B2 (en)
KR (1) KR100873228B1 (en)
CN (1) CN1271197C (en)
AU (1) AU2002226882A1 (en)
CA (1) CA2427990C (en)
WO (1) WO2002044318A1 (en)

Families Citing this family (34)

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Publication number Priority date Publication date Assignee Title
IL136232A0 (en) * 2000-05-18 2001-05-20 Bar Ilan University Res Author Measurements of enzymatic activity in a single, individual cell in population
US6495340B2 (en) * 2000-11-28 2002-12-17 Medis El Ltd. Cell carrier grids
US20020106715A1 (en) * 2001-02-02 2002-08-08 Medisel Ltd System and method for collecting data from individual cells
EP1438753B1 (en) * 2001-10-11 2010-04-07 Koninklijke Philips Electronics N.V. Thin film transistor device and method of manufacturing same
WO2003035824A1 (en) * 2001-10-25 2003-05-01 Bar-Ilan University Interactive transparent individual cells biochip processor
ES2375724T3 (en) 2002-09-27 2012-03-05 The General Hospital Corporation MICROFLUDE DEVICE FOR SEPERATION OF CELLS AND ITS USES.
IL154677A0 (en) * 2003-02-27 2003-09-17 Univ Bar Ilan A method and apparatus for manipulating an individual cell
US20040248205A1 (en) * 2003-04-16 2004-12-09 Stern Lawrence J. Major histocompatibility complex (MHC)-peptide arrays
US8597597B2 (en) 2003-06-26 2013-12-03 Seng Enterprises Ltd. Picoliter well holding device and method of making the same
US7888110B2 (en) 2003-06-26 2011-02-15 Seng Enterprises Ltd. Pico liter well holding device and method of making the same
US9200245B2 (en) * 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
US20050064524A1 (en) * 2003-08-11 2005-03-24 Mordechai Deutsch Population of cells utilizable for substance detection and methods and devices using same
US7403647B2 (en) * 2004-09-13 2008-07-22 Seng Enterprises Ltd. Method for identifying an image of a well in an image of a well-bearing component
US20060057435A1 (en) * 2004-09-15 2006-03-16 Medis Technologies Ltd Method and apparatus for preventing fuel decomposition in a direct liquid fuel cell
ES2352344T3 (en) 2005-01-25 2011-02-17 Seng Enterprises Limited MICROFLUID DEVICE FOR CELL STUDY.
JP4579745B2 (en) * 2005-03-31 2010-11-10 富士通株式会社 Cell capture device
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
DE102005034043B4 (en) * 2005-07-18 2019-12-12 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Mixture containing L-carnitine and trehalulose and product containing the mixture
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
JP4659553B2 (en) * 2005-08-05 2011-03-30 富士通株式会社 Automatic microinjection device and cell capture plate
WO2007052245A1 (en) 2005-11-03 2007-05-10 Seng Enterprises Ltd. Method and device for studying floating, living cells
WO2007102078A1 (en) * 2006-03-08 2007-09-13 Cell Kinetics Ltd. Hole-type cell carriers that promote cell adhesion and/or viability
US20070254276A1 (en) * 2006-04-26 2007-11-01 Seng Enterprises Ltd. Method and system for measuring membrane potential based on fluorescence polarization
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
EP2029779A4 (en) 2006-06-14 2010-01-20 Living Microsystems Inc Use of highly parallel snp genotyping for fetal diagnosis
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
WO2008032323A2 (en) * 2006-09-11 2008-03-20 Seng Enterprises Ltd. Method of determining lymph node metastasis
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
EP2237887A2 (en) * 2007-12-26 2010-10-13 Seng Enterprises Ltd. Device for the study of living cells
EP2334812B1 (en) 2008-09-20 2016-12-21 The Board of Trustees of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
USD802157S1 (en) * 2014-03-02 2017-11-07 Pluristem Ltd. Carrier for cell culture
KR102095466B1 (en) 2018-08-29 2020-03-31 정진우 Ice storage tank of cooling thermal energy storagesystem
CN209331001U (en) * 2018-11-09 2019-09-03 彭秋平 Freezing carries bar

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
US5310674A (en) * 1982-05-10 1994-05-10 Bar-Ilan University Apertured cell carrier
IL68507A (en) * 1982-05-10 1986-01-31 Univ Bar Ilan System and methods for cell selection
US5272081A (en) * 1982-05-10 1993-12-21 Bar-Ilan University System and methods for cell selection
US4772540A (en) * 1985-08-30 1988-09-20 Bar Ilan University Manufacture of microsieves and the resulting microsieves
US4877659A (en) * 1988-08-02 1989-10-31 Inti Corporation Multiwell assay/culture strip
US5183744A (en) * 1988-10-26 1993-02-02 Hitachi, Ltd. Cell handling method for cell fusion processor
US6103479A (en) * 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6022700A (en) * 1998-03-12 2000-02-08 Intelligent Imaging Innovations, Inc. High throughput biological sample preparation device and methods for use thereof
US6495340B2 (en) * 2000-11-28 2002-12-17 Medis El Ltd. Cell carrier grids
US20020106715A1 (en) * 2001-02-02 2002-08-08 Medisel Ltd System and method for collecting data from individual cells

Also Published As

Publication number Publication date
CN1489626A (en) 2004-04-14
JP2004514442A (en) 2004-05-20
US20020094567A1 (en) 2002-07-18
KR100873228B1 (en) 2008-12-10
JP3940361B2 (en) 2007-07-04
US6495340B2 (en) 2002-12-17
EP1337622A1 (en) 2003-08-27
CN1271197C (en) 2006-08-23
KR20030070041A (en) 2003-08-27
AU2002226882A1 (en) 2002-06-11
EP1337622A4 (en) 2006-03-01
WO2002044318A1 (en) 2002-06-06
CA2427990C (en) 2009-03-17

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Effective date: 20131030