CA2431003A1 - Direct wavefront-based corneal ablation treatment program - Google Patents

Direct wavefront-based corneal ablation treatment program Download PDF

Info

Publication number
CA2431003A1
CA2431003A1 CA002431003A CA2431003A CA2431003A1 CA 2431003 A1 CA2431003 A1 CA 2431003A1 CA 002431003 A CA002431003 A CA 002431003A CA 2431003 A CA2431003 A CA 2431003A CA 2431003 A1 CA2431003 A1 CA 2431003A1
Authority
CA
Canada
Prior art keywords
optical
eye
image
tissue
aberration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002431003A
Other languages
French (fr)
Other versions
CA2431003C (en
Inventor
Lawrence W. Stark
John K. Shimmick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AMO Manufacturing USA LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2431003A1 publication Critical patent/CA2431003A1/en
Application granted granted Critical
Publication of CA2431003C publication Critical patent/CA2431003C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/1015Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for wavefront analysis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes

Abstract

A method for measuring an optical system comprises transmitting an image with the optical system. Gradients of the optical system can be determined by separating the transmitted image with a lenslet array. An error-correcting change in the shape of the optical system can be mapped by integrating across the gradients (76). The change in elevation around the path (96) is related to the accuracy of the gradient array. A system for measuring a wavefront of an eye includes an image source for projecting an image into the eye, lenslets, a detector for measuring angles of light rays of an optical surface (34) of an eye, and a computer for mapping the errors of the eye. A tomographic wavefront map is made by deflecting the measurement path of the wavefront sensor.
Aberrations are selected for treatment in response to an order of the aberration and a tissue structure corresponding to the aberration.

Claims (35)

1. A method for measuring optical tissues of an eye, the method comprising:
transmitting an image through the optical tissues;
determining local gradients across the optical tissues from the transmitted image; and mapping an error-correcting change in the optical tissues by integrating across the gradients.
2. The method of claim 1, wherein the image is transmitted from the retina anteriorly through the optical tissues.
3. The method of claim 2, further comprising transmitting a source image from a light source posteriorly through the optical tissues and onto the retina to define the image.
4. The method of claim 3, wherein the image comprises a small spot or point.
5. The method of claim 3, wherein the image is transmitted posteriorly through a central region of the cornea, the central region having a size which is significantly less than a pupil size of the eye.
6. The method of claim 5, wherein the central region has a width of between about 1 and 4 mm.
7. The method of claim 2, wherein the mapping step comprises deriving a proposed change in the optical tissue surface elevations so as to effect a desired change in optical properties of the eye, and further comprising modifying the optical tissue surface according to the proposed change by laser ablation.
8. The method of claim 1, wherein the image is transmitted by the optical tissues as a plurality of beamlets, wherein the gradients comprise an array of gradients, each gradient corresponding to an associated portion of an optical surface, each beamlet being transmitted through the optical tissue according to the corresponding gradient.
9. The method of claim 8, wherein the integrating step comprises integrating along a closed integration path across the gradient array.
10. The method of claim 9, further comprising determining an accuracy of the gradient array by calculating a change in elevation along the closed integration path.
11. The method of claim 9, wherein the closed integration path extends from a first center of a first portion of the optical surface to a second center of a second portion of the optical surface, from the second center to a third center of a third portion of the optical surface, and from the third center back to the first center, the first, second and third portions of the optical surface corresponding to the first, second and third gradients of the gradient array, respectively.
12. The method of claim 9, wherein the closed integration path extends from an initial location corresponding to a position between a first gradient array element and a second gradient array element, the path crossing a first portion of the optical surface corresponding to the second gradient array element, a second portion of the optical surface corresponding to a third gradient array element, and a third portion of the optical surface corresponding to a fourth gradient array element before returning back to the initial location.
13. The method of claim 1, further comprising adjusting the image with an adaptive optical element so as to compensate for errors of the optical system.
14. The method of claim 1, wherein an elevation map of an optical surface of the optical system is generated directly in the mapping step without deriving coefficients of a series expansion mathematically approximating the optical surface.
15. A method for measuring optical tissues of an eye, the method comprising:
transmitting an image through the optical tissue;
determining local gradients across the optical tissue from the transmitted image; and mapping a wavefront error of the eye by integrating the gradients across the tissue.
16. The method of claim 15, wherein the step of integrating further comprises:
integrating along a closed integration path across a gradient array.
17. The method of claim 16, further comprising determining an accuracy of the gradient array by calculating a change in elevation along the closed integration path.
18. A method of determining an accuracy of a gradient array in an optical tissue measurement comprising:
transmitting an image through the optical tissue;
determining local gradients across the optical tissue from the transmitted image; and integrating along a closed integration path across a portion of the array.
19. The method of claim 18, further comprising:
calculating a change in elevation along the closed integration path across the portion of the array.
20. The method of claim 18 wherein, the closed integration path comprises:
a common starting point, a common ending point, a first integration path connecting the common starting point to the common ending point, and a second integration path connecting the common starting point to the common ending point, the first and second integration paths being different.
21. A system for diagnosing an eye of a patient, the eye having a retina and optical tissues, the system comprising:
an image source arranged to direct an image posteriorly through the optical tissues and onto the retina;
a wavefront sensor oriented to sense the image as transmitted anteriorly by the optical tissue, the wavefront sensor generating signals indicating gradients across the optical tissues; and a processor having an integration module configured for integrating among the gradients to determine a map for correction of the optical tissues.
22. The system of claim 21, wherein the processor directly determines a surface elevation map of an optical surface without generating coefficients of a series expansion mathematically approximating the surface.
23. The system of claim 21, wherein the processor comprises a computer executable code performing the method of claim 15 or 18.
24. A method of measuring a tomographic wavefront error map of an eye, the method comprising:
deflecting a light measurement path of a wavefront sensor to a first angular orientation relative to the eye;
measuring the eye at the first angular orientation;
deflecting the light measurement path to a second angular orientation;
measuring the eye at the second angular orientation; and calculating the tomographic wavefront error map of the eye from the sequential measurements, the map comprising a plurality of localized optical tissue surfaces of the eye at different depths of the eye.
25. The method of claim 24 wherein a first optical tissue surface is measured at the first angular orientation and a second optical tissue surface is measured at the second angular orientation, and further comprising:
forming a light structure having a feature on a retina of the eye; and repeating the steps of measuring and deflecting to obtain a plurality of sequential optical tissue surface measurements..
26. The method of claim 25 further comprising displacing a position of the light structure from a first position to a second position so that a feature of the light structure in the second position is resolvable from the feature of the light structure in the first position.
27. A method of selecting an aberration of an eye for treatment comprising:
calculating a tomographic wavefront error map of an eye comprising a plurality of localized optical tissues surfaces of the eye;
corresponding the aberration with a tissue structure of the eye;

selecting the aberration for treatment in response to the structure corresponding to the aberration; and combining a plurality of aberrations selected for treatment to obtain an optical treatment surface.
28. The method of claim 27 further comprising including the aberration corresponding to a corneal tissue structure of an eye and excluding the aberration corresponding to a lenticular tissue structure of an eye.
29. The method of claim 27, wherein the plurality of aberrations selected for treatment is a subset of a plurality of aberrations of the eye.
30. A method of selectively treating an aberration in an optical tissue surface of an eye comprising:
corresponding the aberration with a tissue structure of the eye;
selecting the aberration for treatment in response to the structure corresponding to the aberration;
combining a plurality of aberrations selected for treatment to obtain an optical treatment surface; and sculpting a cornea of the eye with a pattern of laser beam pulses to correct for the selected aberrations of the optical treatment surface.
31. The method of claim 30 further comprising including the aberration corresponding to a corneal tissue structure of an eye and excluding the aberration corresponding to a lenticular tissue structure of the eye.
32. A method of measuring a wavefront map of an eye comprising:
deflecting a light measurement path of a wavefront sensor to a first angular orientation relative to the eye;
measuring a first optical tissue surface of the eye at the first angular orientation of the measurement path relative to the eye;
deflecting the light measurement path to a second angular orientation;
measuring a second optical tissue surface at the second angular orientation;
and calculating the wavefront error map of the eye from the sequential optical tissue surface measurements.
33. The method of claim 32 further comprising repeating the steps of deflecting and measuring to obtain a plurality of optical tissue surface measurements.
34. The method of claim 33 further comprising:
forming a light structure having a feature on the retina; and displacing a position of the light structure from a first position to a second position so that a feature of the light structure in the second position is resolvable from the feature of the light structure in the first position.
35. A machine-readable code comprising instructions for effecting the method recited in claims 24, 27, 30, or 32.
CA2431003A 2000-12-08 2001-12-06 Direct wavefront-based corneal ablation treatment program Expired - Fee Related CA2431003C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25431300P 2000-12-08 2000-12-08
US60/254,313 2000-12-08
PCT/US2001/046573 WO2002046801A2 (en) 2000-12-08 2001-12-06 Direct wavefront-based corneal ablation treatment program

Publications (2)

Publication Number Publication Date
CA2431003A1 true CA2431003A1 (en) 2002-06-13
CA2431003C CA2431003C (en) 2012-03-20

Family

ID=22963793

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2431003A Expired - Fee Related CA2431003C (en) 2000-12-08 2001-12-06 Direct wavefront-based corneal ablation treatment program

Country Status (7)

Country Link
US (1) US7972325B2 (en)
EP (1) EP1358511A4 (en)
JP (1) JP4167064B2 (en)
AU (1) AU2002239515A1 (en)
CA (1) CA2431003C (en)
MX (1) MXPA03005113A (en)
WO (1) WO2002046801A2 (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6820979B1 (en) 1999-04-23 2004-11-23 Neuroptics, Inc. Pupilometer with pupil irregularity detection, pupil tracking, and pupil response detection capability, glaucoma screening capability, intracranial pressure detection capability, and ocular aberration measurement capability
US7156859B2 (en) 2001-07-23 2007-01-02 Fos Holding S.A. Device for separating the epithelium layer from the surface of the cornea of an eye
US7195354B2 (en) 2002-10-04 2007-03-27 The Regents Of The University Of California Adaptive ophthalmologic system
ITTO20021007A1 (en) * 2002-11-19 2004-05-20 Franco Bartoli EXCIMER LASER EQUIPMENT AND DRIVING METHOD
US7460288B2 (en) * 2002-12-06 2008-12-02 Amo Manufacturing Usa, Llc Methods for determining refractive corrections from wavefront measurements
JP4861009B2 (en) * 2002-12-06 2012-01-25 ヴィズイクス・インコーポレーテッド Presbyopia correction using patient data
US6910770B2 (en) 2003-02-10 2005-06-28 Visx, Incorporated Eye refractor with active mirror wavefront sensor
WO2004093663A2 (en) * 2003-04-09 2004-11-04 Visx Incorporated Wavefront calibration analyzer and methods
US7556378B1 (en) 2003-04-10 2009-07-07 Tsontcho Ianchulev Intraoperative estimation of intraocular lens power
US20040263779A1 (en) * 2003-06-12 2004-12-30 Visx, Inc. Hartmann-Shack wavefront measurement
US7168807B2 (en) * 2003-06-20 2007-01-30 Visx, Incorporated Iterative fourier reconstruction for laser surgery and other optical applications
US7175278B2 (en) * 2003-06-20 2007-02-13 Visx, Inc. Wavefront reconstruction using fourier transformation and direct integration
ES2665536T3 (en) 2004-04-20 2018-04-26 Alcon Research, Ltd. Integrated surgical microscope and wavefront sensor
US7387387B2 (en) * 2004-06-17 2008-06-17 Amo Manufacturing Usa, Llc Correction of presbyopia using adaptive optics and associated methods
KR20070108146A (en) * 2004-12-07 2007-11-08 에이옵틱스 테크놀로지스, 인크. Iris imaging using reflection from the eye
US20100153024A1 (en) * 2005-06-28 2010-06-17 Koninklijke Philips Electronics, N.V. Mapping a surface profile
US7261412B2 (en) * 2005-06-30 2007-08-28 Visx, Incorporated Presbyopia correction through negative high-order spherical aberration
US7331674B2 (en) * 2005-09-02 2008-02-19 Visx, Incorporated Calculating Zernike coefficients from Fourier coefficients
AU2007227371B2 (en) * 2006-03-23 2012-02-02 Amo Manufacturing Usa, Llc Systems and methods for wavefront reconstruction for aperture with arbitrary shape
NL2000221C2 (en) * 2006-09-08 2008-03-11 Akkolens Int Bv Device and method for measuring the optical properties of an eye in combination with an operating microscope.
US7575322B2 (en) 2007-05-11 2009-08-18 Amo Development Llc. Auto-alignment and auto-focus system and method
US8016420B2 (en) * 2007-05-17 2011-09-13 Amo Development Llc. System and method for illumination and fixation with ophthalmic diagnostic instruments
US8393734B2 (en) 2007-09-14 2013-03-12 Neuroptics, Inc. Pupilary screening method and system
US7594729B2 (en) 2007-10-31 2009-09-29 Wf Systems, Llc Wavefront sensor
WO2010054268A2 (en) 2008-11-06 2010-05-14 Wavetec Vision Systems, Inc. Optical angular measurement system for ophthalmic applications and method for positioning of a toric intraocular lens with increased accuracy
US7967442B2 (en) 2008-11-28 2011-06-28 Neuroptics, Inc. Methods, systems, and devices for monitoring anisocoria and asymmetry of pupillary reaction to stimulus
US8876290B2 (en) 2009-07-06 2014-11-04 Wavetec Vision Systems, Inc. Objective quality metric for ocular wavefront measurements
WO2011008606A1 (en) 2009-07-14 2011-01-20 Wavetec Vision Systems, Inc. Determination of the effective lens position of an intraocular lens using aphakic refractive power
JP5837489B2 (en) 2009-07-14 2015-12-24 ウェーブテック・ビジョン・システムズ・インコーポレイテッドWavetec Vision Systems, Inc. Ophthalmic equipment
US8409181B2 (en) * 2009-11-05 2013-04-02 Amo Development, Llc. Methods and systems for treating presbyopia
EP2675340A1 (en) * 2011-02-15 2013-12-25 WaveLight GmbH Apparatus for measuring optical properties of an object
GB2490143B (en) * 2011-04-20 2013-03-13 Rolls Royce Plc Method of manufacturing a component
JP5850637B2 (en) * 2011-04-27 2016-02-03 キヤノン株式会社 Fundus imaging apparatus, fundus imaging apparatus control method, and program
US9072462B2 (en) 2012-09-27 2015-07-07 Wavetec Vision Systems, Inc. Geometric optical power measurement device
US10028654B2 (en) 2013-03-15 2018-07-24 Amo Development, Llc System and method for eye orientation
WO2021240392A1 (en) * 2020-05-27 2021-12-02 Alcon Inc. Method of correcting higher-order aberrations using laser vision correction

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4665913A (en) 1983-11-17 1987-05-19 Lri L.P. Method for ophthalmological surgery
EP0158505B1 (en) * 1984-04-13 1989-07-12 Trw Inc. Active mirror wavefront sensor
US4692027A (en) 1985-07-03 1987-09-08 Itek Corporation Spatial processing for single or dual shear wavefront sensor
US4804269A (en) * 1987-08-11 1989-02-14 Litton Systems, Inc. Iterative wavefront measuring device
US5054907A (en) 1989-12-22 1991-10-08 Phoenix Laser Systems, Inc. Ophthalmic diagnostic apparatus and method
US5170193A (en) 1989-12-22 1992-12-08 Phoenix Laser Systems, Inc. Apparatus and method of identifying signals in biological tissues
JP2895150B2 (en) * 1990-03-16 1999-05-24 シチズン時計株式会社 Optical device
US5258791A (en) 1990-07-24 1993-11-02 General Electric Company Spatially resolved objective autorefractometer
CA2073802C (en) 1991-08-16 2003-04-01 John Shimmick Method and apparatus for combined cylindrical and spherical eye corrections
DE4232915A1 (en) 1992-10-01 1994-04-07 Hohla Kristian Device for shaping the cornea by removing tissue
CO4230054A1 (en) 1993-05-07 1995-10-19 Visx Inc METHOD AND SYSTEMS FOR LASER TREATMENT OF REFRACTIVE ERRORS USING TRAVELING IMAGES FORMATION
US5646791A (en) 1995-01-04 1997-07-08 Visx Incorporated Method and apparatus for temporal and spatial beam integration
JPH0915057A (en) * 1995-06-26 1997-01-17 Mitsubishi Electric Corp Wave front sensor and wave front measuring method
US5782822A (en) * 1995-10-27 1998-07-21 Ir Vision, Inc. Method and apparatus for removing corneal tissue with infrared laser radiation
US6271914B1 (en) 1996-11-25 2001-08-07 Autonomous Technologies Corporation Objective measurement and correction of optical systems using wavefront analysis
US5777719A (en) * 1996-12-23 1998-07-07 University Of Rochester Method and apparatus for improving vision and the resolution of retinal images
JP3823266B2 (en) * 1997-05-13 2006-09-20 株式会社トプコン Optical property measuring device
JP3740546B2 (en) * 1997-11-11 2006-02-01 株式会社トプコン Ophthalmic measuring device
US6280435B1 (en) * 1998-03-04 2001-08-28 Visx, Incorporated Method and systems for laser treatment of presbyopia using offset imaging
JP3431828B2 (en) * 1998-04-09 2003-07-28 三菱電機株式会社 Wavefront sensor
US6834238B1 (en) * 1998-06-08 2004-12-21 Cytoscan Sciences Llc Method for identifying optical contrast enhancing agents
US6000800A (en) 1998-06-22 1999-12-14 Schepens Eye Research Institute Coaxial spatially resolved refractometer
US6099125A (en) 1998-12-07 2000-08-08 Schepens Eye Research Foundation Coaxial spatially resolved refractometer
US6004313A (en) 1998-06-26 1999-12-21 Visx, Inc. Patient fixation system and method for laser eye surgery
US6011625A (en) * 1998-07-08 2000-01-04 Lockheed Martin Corporation Method for phase unwrapping in imaging systems
GB9820664D0 (en) * 1998-09-23 1998-11-18 Isis Innovation Wavefront sensing device
DE19904753C1 (en) * 1999-02-05 2000-09-07 Wavelight Laser Technologie Gm Device for photorefractive corneal surgery of the eye for correcting high-order visual defects
EP1037166A1 (en) * 1999-03-16 2000-09-20 Philips Corporate Intellectual Property GmbH Method for the detection of contours in an X-Ray image
JP2000283853A (en) * 1999-03-31 2000-10-13 Mitsubishi Electric Corp Wavefront sensor
US6294775B1 (en) * 1999-06-08 2001-09-25 University Of Washington Miniature image acquistion system using a scanning resonant waveguide
US6563105B2 (en) * 1999-06-08 2003-05-13 University Of Washington Image acquisition with depth enhancement
US6050687A (en) 1999-06-11 2000-04-18 20/10 Perfect Vision Optische Geraete Gmbh Method and apparatus for measurement of the refractive properties of the human eye
US6199986B1 (en) * 1999-10-21 2001-03-13 University Of Rochester Rapid, automatic measurement of the eye's wave aberration
US6486943B1 (en) * 2000-09-19 2002-11-26 The Schepens Eye Research Institute, Inc. Methods and apparatus for measurement and correction of optical aberration
US6331059B1 (en) 2001-01-22 2001-12-18 Kestrel Corporation High resolution, multispectral, wide field of view retinal imager

Also Published As

Publication number Publication date
EP1358511A4 (en) 2009-01-07
JP4167064B2 (en) 2008-10-15
EP1358511A2 (en) 2003-11-05
WO2002046801A2 (en) 2002-06-13
AU2002239515A1 (en) 2002-06-18
JP2004524063A (en) 2004-08-12
CA2431003C (en) 2012-03-20
US20020135736A1 (en) 2002-09-26
MXPA03005113A (en) 2004-01-29
WO2002046801A3 (en) 2003-02-06
US7972325B2 (en) 2011-07-05

Similar Documents

Publication Publication Date Title
CA2431003A1 (en) Direct wavefront-based corneal ablation treatment program
US5920373A (en) Method and apparatus for determining optical characteristics of a cornea
JP3621044B2 (en) Objective measurement and correction of optical systems using wavefront analysis
US9713420B2 (en) Optical instrument alignment system
US7303281B2 (en) Method and device for determining refractive components and visual function of the eye for vision correction
US6271915B1 (en) Objective measurement and correction of optical systems using wavefront analysis
JP3452860B2 (en) A device for measuring the refractive properties of the human eye
ES2223874T3 (en) OBJECTIVE MEASUREMENT AND CORRECTION OF OPTICAL SYSTEMS USED BY THE WAVE FRONT ANALYSIS.
US7339658B2 (en) Device and method for measuring surface topography and wave aberration of a lens system, in particular an eye
MXPA01013364A (en) Spatial filter for enhancing hartmann shack images and associated methods.
JP2004524051A (en) Wavefront sensor and method for objective measurement of optical system
JP2004507306A (en) Non-contact measurement system for optical imaging quality of the eye
US7296895B2 (en) Sequential scanning wavefront measurement and retinal topography
JP3898108B2 (en) Eye characteristics measuring device
JP4231273B2 (en) Eye characteristics measuring device
WO2003051189A2 (en) Improved hartmann-shack wavefront sensor apparatus and method
JP4562234B2 (en) Eye characteristic measuring device
JP2004255010A (en) Apparatus for measuring refractive power of eye
WO2005048819A2 (en) Method and device for determining refractive components and visual function of the eye for vision correction
MXPA00004897A (en) Objective measurement and correction of optical systems using wavefront analysis

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20210831

MKLA Lapsed

Effective date: 20191206