CA2434305A1 - Sample deposition method and system - Google Patents
Sample deposition method and system Download PDFInfo
- Publication number
- CA2434305A1 CA2434305A1 CA002434305A CA2434305A CA2434305A1 CA 2434305 A1 CA2434305 A1 CA 2434305A1 CA 002434305 A CA002434305 A CA 002434305A CA 2434305 A CA2434305 A CA 2434305A CA 2434305 A1 CA2434305 A1 CA 2434305A1
- Authority
- CA
- Canada
- Prior art keywords
- liquid droplet
- sample plate
- electric field
- deposition system
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
- B01J2219/00367—Pipettes capillary
- B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
- B01J2219/00371—Pipettes comprising electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00691—Automatic using robots
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
- B01L2300/0838—Capillaries
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
- B01L2400/027—Drop detachment mechanisms of single droplets from nozzles or pins electrostatic forces between substrate and tip
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Abstract
This invention provides methods and systems for rapidly, accurately and efficiently depositing liquid droplets (130) onto a planar uper surface (117) of sample plate (115) held in sample plate holder (110) which is supported on, or incorporated into, a motion table (105) included in an LC MALDI sample distribution system (100) for MALDI-mass spectrometry sample preparation.
System (100) also includes a holding mechanism (118) for holding at least one capillary (125) which terminates at a capillary tip (127) on which droplet (130) is formed. A power supply (135) forms an electric field between sample plate surface (117) and droplet (130) which acts to pull the droplet (130) onto the sample plate (115).
System (100) also includes a holding mechanism (118) for holding at least one capillary (125) which terminates at a capillary tip (127) on which droplet (130) is formed. A power supply (135) forms an electric field between sample plate surface (117) and droplet (130) which acts to pull the droplet (130) onto the sample plate (115).
Claims (41)
1. A method of depositing a liquid droplet, the method comprising:
providing a sample plate at a distance from a liquid droplet; and generating an electric field between the liquid droplet and the sample plate to polarize the liquid droplet, wherein the liquid droplet is either charged or grounded;
wherein the liquid droplet is pulled to the sample plate along the electric field.
providing a sample plate at a distance from a liquid droplet; and generating an electric field between the liquid droplet and the sample plate to polarize the liquid droplet, wherein the liquid droplet is either charged or grounded;
wherein the liquid droplet is pulled to the sample plate along the electric field.
2. The method of claim 1, wherein providing a sample plate comprises moving the sample plate to a target position.
3. The method of claim 1, wherein the liquid droplet is pulled to a target location on the sample plate.
4. The method of claim 1, wherein the liquid droplet is provided at a tip of a capillary.
5. The method of claim 4, wherein the capillary is connected to a column.
6. The method of claim 1, wherein generating an electric field comprises applying a charge to the liquid droplet.
7. The method of claim 6, wherein generating an electric field comprises connecting the sample plate to ground.
8. The method of claim 7, wherein the sample plate is connected to ground indirectly via an electrode plate that underlies the sample plate.
9. The method of claim 1, wherein generating an electric field comprises applying a charge to the sample plate.
10. The method of claim 9, wherein the charge is applied to the sample plate indirectly via an electrode plate that underlies the sample plate.
11. The method of claim 9, wherein generating an electric field comprises connecting the liquid droplet to ground.
12. The method of claim 1, wherein generating an electric field comprises applying a charge to one or more auxiliary electrodes.
13. The method of claim 1, wherein the distance between the liquid droplet and the sample plate is less than ten millimeters.
14. The method of claim 13, wherein the distance between the liquid droplet and the sample plate is approximately five millimeters.
15. The method of claim 1, wherein the electric field has a duration of 100-300 milliseconds.
16. The method of claim 15, wherein the electric field has a duration of approximately 200 milliseconds.
17. The method of claim 1, wherein the electric field has a potential difference of 500-3000 volts.
18. The method of claim 17, wherein the potential difference is approximately 1000 volts.
19. The method of claim 1, wherein two or more drops are deposited at each target location on the sample plate.
20. The method of claim 1, wherein the liquid droplet comprises sample molecules.
21. The method of claim 1, wherein the liquid droplet comprises matrix molecules suitable for MALDI.
22. The method of claim 1, wherein the sample droplet comprises a mixture of sample molecules and matrix molecules.
23. A liquid droplet deposition system, comprising:
a holding mechanism;
a plurality of capillaries, held by the holding mechanism;
a sample plate holder positionable with respect to the plurality of capillaries; and a power supply configured to generate an electric field between each capillary and a sample plate when the sample plate is placed upon the sample plate holder, along which electric field a droplet of liquid which can form at an end of the capillary is pulled to the sample plate.
a holding mechanism;
a plurality of capillaries, held by the holding mechanism;
a sample plate holder positionable with respect to the plurality of capillaries; and a power supply configured to generate an electric field between each capillary and a sample plate when the sample plate is placed upon the sample plate holder, along which electric field a droplet of liquid which can form at an end of the capillary is pulled to the sample plate.
24. The liquid droplet deposition system of claim 23, wherein each capillary comprises:
a column for containing a liquid from which the liquid droplet is formed;
and a capillary, connected at a first end to the column, and including an open tip at a second end for providing the droplets.
a column for containing a liquid from which the liquid droplet is formed;
and a capillary, connected at a first end to the column, and including an open tip at a second end for providing the droplets.
25. The liquid droplet deposition system of claim 23, wherein the column comprises a liquid chromatography column.
26. The liquid droplet deposition system of claim 23, wherein the sample plate holder is movable.
27. The liquid droplet deposition system of claim 23, wherein a sample plate is positioned on the sample plate holder below the array of capillaries.
28. The liquid droplet deposition system of claim 27, further comprising means for moving the sample plate to a target position.
29. The liquid droplet deposition system of claim 27, wherein the power supply includes a voltage source far applying a charge to the sample plate.
30. The liquid droplet deposition system of claim 29, wherein system comprises an electrode plate through which the charge is applied indirectly to the sample plate.
31. The liquid droplet deposition system of claim 29, wherein the system comprises an electrical connection which grounds a liquid droplet at an end of the capillary.
32. The liquid droplet deposition system of claim 23, wherein the power supply permits the independent application of a charge to each of a plurality of liquid droplets.
33. The liquid droplet deposition system of claim 23, wherein the power supply permits the independent application of a charge to different parts of the sample plate.
34. The liquid droplet deposition system of claim 33, wherein the power supply further includes a ground connection for grounding the liquid droplet.
35. The liquid droplet deposition system of claim 23, wherein the power supply includes a voltage source for applying a charge to the liquid droplet.
36. The liquid droplet deposition system of claim 23, further comprising a controller which controls one or more parameters selected from the group consisting of movement of the sample plate, intensity of the electric field, duration of the electric field, and frequency of application of the electric field.
37. The liquid droplet deposition system of claim 36, wherein the controller comprises a computer which is programmed with software which provides a user interface which allows an operator to set parameters for the sample deposition.
38. The liquid droplet deposition system of claim 23, wherein the capillary is connected to a liquid chromatography column.
39. A liquid droplet deposition method, comprising:
providing a plurality of liquid droplets above a positionable sample plate;
and attracting each droplet to a target location on the sample plate with an electric field foamed between the plurality of droplets and the sample plate, wherein the liquid droplets are either charged or grounded.
providing a plurality of liquid droplets above a positionable sample plate;
and attracting each droplet to a target location on the sample plate with an electric field foamed between the plurality of droplets and the sample plate, wherein the liquid droplets are either charged or grounded.
44. The method of claim 39, wherein the plurality of liquid droplets includes eight or more droplets.
41. The method of claim 39, wherein attracting each droplet to a target location is performed in a succession to a single target location.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/765,207 | 2001-01-17 | ||
US09/765,207 US6918309B2 (en) | 2001-01-17 | 2001-01-17 | Sample deposition method and system |
PCT/US2002/001536 WO2002062475A1 (en) | 2001-01-17 | 2002-01-17 | Sample deposition method and system |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2434305A1 true CA2434305A1 (en) | 2002-08-15 |
CA2434305C CA2434305C (en) | 2010-03-09 |
Family
ID=25072933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002434305A Expired - Fee Related CA2434305C (en) | 2001-01-17 | 2002-01-17 | Sample deposition method and system |
Country Status (8)
Country | Link |
---|---|
US (2) | US6918309B2 (en) |
EP (1) | EP1358012B1 (en) |
JP (1) | JP4162207B2 (en) |
AT (1) | ATE403496T1 (en) |
AU (1) | AU2007221973B2 (en) |
CA (1) | CA2434305C (en) |
DE (1) | DE60228049D1 (en) |
WO (1) | WO2002062475A1 (en) |
Cited By (1)
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WO2006084376A1 (en) * | 2005-02-09 | 2006-08-17 | The University Of British Columbia | Sub-microlitre electrostatic dispenser |
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US20020003177A1 (en) * | 2000-03-17 | 2002-01-10 | O'connor Stephen D. | Electrostatic systems and methods for dispensing liquids |
US6918309B2 (en) * | 2001-01-17 | 2005-07-19 | Irm Llc | Sample deposition method and system |
US6657191B2 (en) * | 2001-03-02 | 2003-12-02 | Bruker Daltonics Inc. | Means and method for multiplexing sprays in an electrospray ionization source |
-
2001
- 2001-01-17 US US09/765,207 patent/US6918309B2/en not_active Expired - Fee Related
-
2002
- 2002-01-17 CA CA002434305A patent/CA2434305C/en not_active Expired - Fee Related
- 2002-01-17 DE DE60228049T patent/DE60228049D1/en not_active Expired - Lifetime
- 2002-01-17 JP JP2002562474A patent/JP4162207B2/en not_active Expired - Fee Related
- 2002-01-17 AT AT02718848T patent/ATE403496T1/en not_active IP Right Cessation
- 2002-01-17 WO PCT/US2002/001536 patent/WO2002062475A1/en active Application Filing
- 2002-01-17 EP EP02718848A patent/EP1358012B1/en not_active Expired - Lifetime
-
2005
- 2005-06-20 US US11/160,350 patent/US7578206B2/en not_active Expired - Fee Related
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2007
- 2007-10-12 AU AU2007221973A patent/AU2007221973B2/en not_active Ceased
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006084376A1 (en) * | 2005-02-09 | 2006-08-17 | The University Of British Columbia | Sub-microlitre electrostatic dispenser |
Also Published As
Publication number | Publication date |
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AU2007221973B2 (en) | 2009-12-10 |
CA2434305C (en) | 2010-03-09 |
JP4162207B2 (en) | 2008-10-08 |
WO2002062475B1 (en) | 2002-11-21 |
US20050232823A1 (en) | 2005-10-20 |
US6918309B2 (en) | 2005-07-19 |
EP1358012A4 (en) | 2006-04-05 |
EP1358012B1 (en) | 2008-08-06 |
AU2007221973A1 (en) | 2007-11-01 |
US7578206B2 (en) | 2009-08-25 |
ATE403496T1 (en) | 2008-08-15 |
JP2004529325A (en) | 2004-09-24 |
WO2002062475A1 (en) | 2002-08-15 |
US20020092366A1 (en) | 2002-07-18 |
EP1358012A1 (en) | 2003-11-05 |
DE60228049D1 (en) | 2008-09-18 |
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