CA2434604A1 - Cartridge for containing a specimen sample for optical analysis - Google Patents
Cartridge for containing a specimen sample for optical analysis Download PDFInfo
- Publication number
- CA2434604A1 CA2434604A1 CA002434604A CA2434604A CA2434604A1 CA 2434604 A1 CA2434604 A1 CA 2434604A1 CA 002434604 A CA002434604 A CA 002434604A CA 2434604 A CA2434604 A CA 2434604A CA 2434604 A1 CA2434604 A1 CA 2434604A1
- Authority
- CA
- Canada
- Prior art keywords
- seal
- test chamber
- liquid
- inlet
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/11—Filling or emptying of cuvettes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
Abstract
A cartridge (21) for holding a test specimen with an extremely small volume.
The cartridge has a test chamber (63) and a vestibule (66) through which the test fluids are inserted into the test chamber. The cartridge has a stopper (60) having a pair of seals (72, 74), the first of which seals the test chamber inlet (65) between the vestibule and the test chamber, and the second of which seals the mouth (67) of the vestibule so that when the stopper is in place, the test chamber is closed to the admission of air other contaminants and the vestibule is similarly closed against escape of the overflow from the test chamber.
The cartridge has a test chamber (63) and a vestibule (66) through which the test fluids are inserted into the test chamber. The cartridge has a stopper (60) having a pair of seals (72, 74), the first of which seals the test chamber inlet (65) between the vestibule and the test chamber, and the second of which seals the mouth (67) of the vestibule so that when the stopper is in place, the test chamber is closed to the admission of air other contaminants and the vestibule is similarly closed against escape of the overflow from the test chamber.
Claims (18)
1. A method sealing a chamber to preclude air entrapment in a test liquid, comprising:
(a) providing an analytic chamber having a test chamber and an overflow reservoir;
(b) filling the analytic chamber to a fill line such that the test chamber is completely filled with liquid;
(c) seating a primary seal within the analytic chamber to form a seal interface that lies between the test chamber and the overflow reservoir within the liquid volume in the analytic chamber;
(d) retaining any evacuated liquid displaced upon seating the primary seal into the overflow reservoir; and (e) sealing the overflow reservoir with a second seal to preclude voiding of the overflow reservoir and rupturing of the primary seal.
(a) providing an analytic chamber having a test chamber and an overflow reservoir;
(b) filling the analytic chamber to a fill line such that the test chamber is completely filled with liquid;
(c) seating a primary seal within the analytic chamber to form a seal interface that lies between the test chamber and the overflow reservoir within the liquid volume in the analytic chamber;
(d) retaining any evacuated liquid displaced upon seating the primary seal into the overflow reservoir; and (e) sealing the overflow reservoir with a second seal to preclude voiding of the overflow reservoir and rupturing of the primary seal.
2. A method according to Claim 1 in which said step of filling the chamber with liquid includes one step of introducing a test liquid into the chamber having a volume sufficient to fill the test chamber to a level below said fill line, and a second step of introducing a buffer solution having a density different from the density of the test liquid to the chamber, the combined volume of said test liquid and said buffer being sufficient to bring the surface of said combined liquids to said fill line, said test liquid and buffer solution providing a liquid interface within the test chamber having buffer solution on one side and test liquid at the other side, said seating step displacing buffer solution from the one side of said liquid interface into said overflow reservoir, whereby all of said test liquid is retained in the test chamber, and air is excluded from the test chamber.
3. A method according to Claim 2 in which said overflow reservoir is above said test chamber and said buffer solution has a density not more than the density of the test liquid, including the steps of connecting the overflow reservoir to the test chamber by an inlet adjacent to said fill line and spaced above the liquid interface, and seating said primary seal in the inlet.
4. A method according to claim 1, including the steps of providing a stopper having a primary sealing element adjacent its distal end and a second sealing element adjacent its proximal end, inserting the stopper into and through the overflow reservoir to seat the primary sealing element between the test chamber and the reservoir, the distal end of said stopper displacing liquid from the test chamber into the reservoir, and thereafter seating the second sealing element to seal the overflow reservoir.
5. A seal system for sealing a test chamber to preclude air entrapment in liquid inserted into the chamber, said system comprising:
(a) a test chamber having a longitudinal axis adapted to be disposed vertically as liquid is inserted therein, and having a vestibule above said test chamber, an inlet between said test chamber and said vestibule, and a fill line located adjacent said inlet, said fill line determined by the surface of liquid inserted into said test chamber;
(b) a stopper having a first seal adapted to sealingly seat in the inlet and close the same, said stopper having a distal end adapted to enter the inlet of the test chamber below the fill line before the first seal closes said inlet, said distal end having a thickness sufficient to displace upwardly liquid through said inlet and position the surface of the liquid in said vestibule prior to said first seal closing said inlet, said first seal, upon being seated in the inlet, precluding air entrapment within the test chamber;
(c) said vestibule having a volume to form an overflow reservoir for receiving a volume of liquid that may be displaced upon seating the primary seal; and (d) a second seal remote form the first seal in said vestibule, said first and second seals defining therebetween the overflow reservoir, said second seal precluding migration of any overflow liquid past the second seal out of the system.
(a) a test chamber having a longitudinal axis adapted to be disposed vertically as liquid is inserted therein, and having a vestibule above said test chamber, an inlet between said test chamber and said vestibule, and a fill line located adjacent said inlet, said fill line determined by the surface of liquid inserted into said test chamber;
(b) a stopper having a first seal adapted to sealingly seat in the inlet and close the same, said stopper having a distal end adapted to enter the inlet of the test chamber below the fill line before the first seal closes said inlet, said distal end having a thickness sufficient to displace upwardly liquid through said inlet and position the surface of the liquid in said vestibule prior to said first seal closing said inlet, said first seal, upon being seated in the inlet, precluding air entrapment within the test chamber;
(c) said vestibule having a volume to form an overflow reservoir for receiving a volume of liquid that may be displaced upon seating the primary seal; and (d) a second seal remote form the first seal in said vestibule, said first and second seals defining therebetween the overflow reservoir, said second seal precluding migration of any overflow liquid past the second seal out of the system.
6. A system according to Claim 5 wherein said test chamber is separated from said vestibule by the top wall of the test chamber and wherein further said inlet is positioned within said top wall.
7. A system according to Claim 5 in which said stopper has a stem adapted to extend through said vestibule, with a distal end adapted to pass through said inlet of said test chamber and a proximal end adapted to be positioned above said vestibule, said first seal being positioned on said stem adjacent the distal end, and the second seal being positioned on said stem adjacent the proximal end.
8. A system according to Claim 7 wherein said inlet comprises a tapered passage terminating in a cylindrical channel providing a seat for said first seal, and an upwardly open mouth providing a seat for the second seal, said first seal comprising a probe at the distal end of said stem adapted to pass through said tapered passage and into said cylindrical channel to seal the inlet, and said second seal comprising a plug adapted to sealingly engage in said open mouth.
9. A system according to Claim 8 wherein said cylindrical channel is disposed centrally in the top wall of said test chamber and has an internal diameter substantially smaller than the internal dimensions of the test chamber.
10. A system according to Claim 8 wherein the distance between the distal end of the probe and the plug is greater than the distance between the cylindrical channel and the mouth, whereby the probe completes the first seal before the plug effects the second seal.
11. A system according to claim 10 wherein said mouth is a socket, and said plug is a block complementary to said socket.
12. A system according to claim 10 wherein said stem has ribs extending between said probe and said plug.
13. A system according to claim 5 wherein said test chamber has longitudinal side walls of translucent plastic material with no fluorescent additives to enable optical analysis of the liquid inserted in the test chamber.
14. A system according to claim 13 wherein at least one of said longitudinal sidewalls of the test chamber is flat.
15. A cartridge containing a test chamber for use in apparatus for performing optical analysis of liquid specimens by optical observation, said apparatus having a receptacle for receiving the cartridge and positioning the test chamber of the cartridge in a field of observation of the apparatus to enable analysis of liquid within the test chamber, the apparatus having at least two magnetic poles positioned on opposite sides of the receptacle to apply a magnetic field to the cartridge, said cartridge comprising:
a body of translucent plastic adapted to be slidably engaged in the receptacle of the apparatus between said magnetic poles to position the test chamber in the magnetic field of said poles, said body having a domed cross section with a flat land area adapted to be positioned in the field of observation of the apparatus, a test chamber underlying said flat land area and having a longitudinal axis adapted to be disposed vertically when liquid is inserted therein, and having a vestibule above said test chamber, an inlet between said test chamber and said vestibule, and a fill line located adjacent said inlet, said fill line determined by the surface of liquid inserted into said test chamber;
a stopper having a first seal adapted to sealingly seat in the inlet and close the same, said stopper having a distal end adapted to enter the inlet of the test chamber below the fill line before the first seal closes said inlet, said distal end having a thickness sufficient to displace liquid upwardly through said inlet and position the surface of the liquid in said vestibule prior to said first seal closing said inlet, said first seal, upon being seated in the inlet, precluding air entrapment within the test chamber;
said vestibule having a volume to form an overflow reservoir for receiving a volume of liquid that may be displaced upon seating the primary seal;
and a second seal remote form the first seal in said vestibule, said first and second seals defining therebetween the overflow reservoir, said second seal precluding migration of any overflow liquid past the second seal out of the system.
a body of translucent plastic adapted to be slidably engaged in the receptacle of the apparatus between said magnetic poles to position the test chamber in the magnetic field of said poles, said body having a domed cross section with a flat land area adapted to be positioned in the field of observation of the apparatus, a test chamber underlying said flat land area and having a longitudinal axis adapted to be disposed vertically when liquid is inserted therein, and having a vestibule above said test chamber, an inlet between said test chamber and said vestibule, and a fill line located adjacent said inlet, said fill line determined by the surface of liquid inserted into said test chamber;
a stopper having a first seal adapted to sealingly seat in the inlet and close the same, said stopper having a distal end adapted to enter the inlet of the test chamber below the fill line before the first seal closes said inlet, said distal end having a thickness sufficient to displace liquid upwardly through said inlet and position the surface of the liquid in said vestibule prior to said first seal closing said inlet, said first seal, upon being seated in the inlet, precluding air entrapment within the test chamber;
said vestibule having a volume to form an overflow reservoir for receiving a volume of liquid that may be displaced upon seating the primary seal;
and a second seal remote form the first seal in said vestibule, said first and second seals defining therebetween the overflow reservoir, said second seal precluding migration of any overflow liquid past the second seal out of the system.
16. A cartridge according to claim 15 wherein said test chamber has a volume of at least 315 NI and said vestibule has a volume of at least 95,u1 when the first of said stopper seals is seated in the inlet and the second seal is precluding migration of any overflow liquid past the second seal.
17. A cartridge according to claim 15 wherein said test chamber has a volume in the range of 22 ml to 675 µl.
18. A cartridge according to claim 15 wherein said test chamber has a cross-sectional area in the range of 10 to 14 square millimeters and the inlet has a diameter of 2.35 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2708573A CA2708573C (en) | 2001-02-12 | 2002-02-12 | Cartridge for containing a specimen sample for optical analysis |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26810101P | 2001-02-12 | 2001-02-12 | |
| US60/268,101 | 2001-02-12 | ||
| PCT/US2002/004124 WO2002065103A1 (en) | 2001-02-12 | 2002-02-12 | Cartridge for containing a specimen sample for optical analysis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2708573A Division CA2708573C (en) | 2001-02-12 | 2002-02-12 | Cartridge for containing a specimen sample for optical analysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2434604A1 true CA2434604A1 (en) | 2002-08-22 |
| CA2434604C CA2434604C (en) | 2010-09-28 |
Family
ID=23021476
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2434604A Expired - Fee Related CA2434604C (en) | 2001-02-12 | 2002-02-12 | Cartridge for containing a specimen sample for optical analysis |
| CA2708573A Expired - Fee Related CA2708573C (en) | 2001-02-12 | 2002-02-12 | Cartridge for containing a specimen sample for optical analysis |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2708573A Expired - Fee Related CA2708573C (en) | 2001-02-12 | 2002-02-12 | Cartridge for containing a specimen sample for optical analysis |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6861259B2 (en) |
| EP (1) | EP1360471B1 (en) |
| JP (1) | JP3766064B2 (en) |
| KR (1) | KR20030074816A (en) |
| CN (1) | CN1491355A (en) |
| AT (1) | ATE340360T1 (en) |
| AU (1) | AU2002243968B2 (en) |
| BR (1) | BR0207095A (en) |
| CA (2) | CA2434604C (en) |
| DE (1) | DE60214827T2 (en) |
| IL (1) | IL156741A0 (en) |
| WO (1) | WO2002065103A1 (en) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7863012B2 (en) * | 2004-02-17 | 2011-01-04 | Veridex, Llc | Analysis of circulating tumor cells, fragments, and debris |
| US7764821B2 (en) | 2002-02-14 | 2010-07-27 | Veridex, Llc | Methods and algorithms for cell enumeration in a low-cost cytometer |
| AU2003219759B2 (en) | 2002-02-14 | 2011-01-20 | Veridex, Llc | Methods and algorithms for cell enumeration in a low-cost cytometer |
| US7011794B2 (en) | 2002-11-25 | 2006-03-14 | Immunivest Corporation | Upon a cartridge for containing a specimen sample for optical analysis |
| US7682833B2 (en) | 2003-09-10 | 2010-03-23 | Abbott Point Of Care Inc. | Immunoassay device with improved sample closure |
| US20050181353A1 (en) * | 2004-02-17 | 2005-08-18 | Rao Galla C. | Stabilization of cells and biological specimens for analysis |
| US8189899B2 (en) * | 2004-07-30 | 2012-05-29 | Veridex, Llc | Methods and algorithms for cell enumeration in a low-cost cytometer |
| US7901950B2 (en) * | 2005-08-12 | 2011-03-08 | Veridex, Llc | Method for assessing disease states by profile analysis of isolated circulating endothelial cells |
| US7777885B2 (en) * | 2005-08-17 | 2010-08-17 | Veridex, Llc | Diagnostic imaging device for the analysis of circulating rare cells |
| JP5457673B2 (en) * | 2005-09-20 | 2014-04-02 | ベリデックス・リミテッド・ライアビリティ・カンパニー | Methods and compositions for making unique sequence DNA probes, labeling of DNA probes, and use of these probes |
| US9134237B2 (en) * | 2005-09-20 | 2015-09-15 | Janssen Diagnotics, LLC | High sensitivity multiparameter method for rare event analysis in a biological sample |
| US8337755B2 (en) * | 2006-03-13 | 2012-12-25 | Veridex, Llc | Operator independent programmable sample preparation and analysis system |
| US7722822B2 (en) * | 2006-03-23 | 2010-05-25 | Agilent Technologies, Inc. | Sample tube and vial processing system, and method for processing the sample |
| US8003314B2 (en) | 2007-04-16 | 2011-08-23 | Diagnostic Hybrids, Inc. | Methods for direct fluorescent antibody virus detection in liquids |
| US8003060B2 (en) * | 2007-05-18 | 2011-08-23 | Axela Inc. | Reaction vessel with integrated optical and fluid control elements |
| US8110101B2 (en) * | 2007-08-30 | 2012-02-07 | Veridex, Llc | Method and apparatus for imaging target components in a biological sample using permanent magnets |
| US7828968B2 (en) | 2007-08-30 | 2010-11-09 | Veridex, Llc | Method and apparatus for imaging target components in a biological sample using permanent magnets |
| US8758267B2 (en) * | 2009-03-17 | 2014-06-24 | Nova Biomedical Corporation | Modified lancet carrier for single-use lancet sensor assembly |
| US8790916B2 (en) | 2009-05-14 | 2014-07-29 | Genestream, Inc. | Microfluidic method and system for isolating particles from biological fluid |
| WO2011071772A2 (en) * | 2009-12-07 | 2011-06-16 | Meso Scale Technologies, Llc. | Assay cartridges and methods of using the same |
| CN103237901B (en) | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | For treating the biomarker of diagnosis |
| WO2011127219A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings | Circulating biomarkers for disease |
| CA2817283C (en) | 2010-10-05 | 2020-07-14 | Anpac Bio-Medical Science Co., Ltd. | Micro-devices for disease detection |
| GB2488559A (en) * | 2011-03-01 | 2012-09-05 | Univ Bristol | Apparatus for testing the quality of drinking water |
| WO2012128841A2 (en) | 2011-03-24 | 2012-09-27 | Anpac Bio-Medical Science Co., Ltd. | Micro-devices for disease detection |
| WO2013016600A2 (en) | 2011-07-28 | 2013-01-31 | The Trustees Of The University Of Pennsylvania | Methods and reagents for diagnosing conditions and characterization of tumor cells associated with serous fluids |
| US10466160B2 (en) | 2011-08-01 | 2019-11-05 | Celsee Diagnostics, Inc. | System and method for retrieving and analyzing particles |
| CA2842359A1 (en) | 2011-08-01 | 2013-02-07 | Denovo Sciences | Cell capture system and method of use |
| US9404864B2 (en) | 2013-03-13 | 2016-08-02 | Denovo Sciences, Inc. | System for imaging captured cells |
| US9174216B2 (en) | 2013-03-13 | 2015-11-03 | DeNovo Science, Inc. | System for capturing and analyzing cells |
| US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
| US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
| US9081001B2 (en) | 2012-05-15 | 2015-07-14 | Wellstat Diagnostics, Llc | Diagnostic systems and instruments |
| WO2014091321A1 (en) * | 2012-12-13 | 2014-06-19 | Koninklijke Philips N.V. | Cartridge and apparatus for preparing a biological sample |
| US9606102B2 (en) | 2013-01-26 | 2017-03-28 | Denovo Sciences, Inc. | System and method for capturing and analyzing cells |
| US9707562B2 (en) | 2013-03-13 | 2017-07-18 | Denovo Sciences, Inc. | System for capturing and analyzing cells |
| US10391490B2 (en) | 2013-05-31 | 2019-08-27 | Celsee Diagnostics, Inc. | System and method for isolating and analyzing cells |
| US9856535B2 (en) | 2013-05-31 | 2018-01-02 | Denovo Sciences, Inc. | System for isolating cells |
| JP6551835B2 (en) * | 2014-08-22 | 2019-07-31 | パナソニックＩｐマネジメント株式会社 | Socket, Adapter, and Assembly Jig |
| US9476875B2 (en) | 2015-03-02 | 2016-10-25 | Chembio Diagnostic Systems, Inc. | Integrated buffer dual-path immunoassay device |
| DE102016104808A1 (en) | 2016-03-15 | 2017-09-21 | Als Automated Lab Solutions Gmbh | Device for insertion into an imaging system |
| EP3651903A4 (en) | 2017-08-29 | 2021-06-16 | Bio-Rad Laboratories, Inc. | System and method for isolating and analyzing cells |
| US11375986B1 (en) * | 2018-07-27 | 2022-07-05 | The University Of Chicago | Device and method for stool sample collection |
| US10633693B1 (en) | 2019-04-16 | 2020-04-28 | Celsee Diagnostics, Inc. | System and method for leakage control in a particle capture system |
| CN114072490A (en) | 2019-05-07 | 2022-02-18 | 伯乐实验室有限公司 | System and method for automated single cell processing |
| US11273439B2 (en) | 2019-05-07 | 2022-03-15 | Bio-Rad Laboratories, Inc. | System and method for target material retrieval from microwells |
| WO2020251802A1 (en) | 2019-06-14 | 2020-12-17 | Bio-Rad Laboratories, Inc. | System and method for automated single cell processing and analyses |
| US11504719B2 (en) | 2020-03-12 | 2022-11-22 | Bio-Rad Laboratories, Inc. | System and method for receiving and delivering a fluid for sample processing |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3124281A (en) | 1964-03-10 | stull | ||
| US3276640A (en) | 1965-03-08 | 1966-10-04 | Kessler Milton | Closable pouring spout and an axially slidable cap moving a plug thereon for liquid containers |
| US4091802A (en) * | 1976-02-17 | 1978-05-30 | Eastman Kodak Company | Vented liquid collection device |
| DE3036139A1 (en) | 1980-09-25 | 1982-05-06 | Hans 8801 Schillingsfürst Heinlein | SPOUT FOR BOTTLE-LIKE CONTAINERS |
| US4559610A (en) * | 1983-05-04 | 1985-12-17 | Southwest Research Corporation | Gas pumping system analog |
| IT8322185V0 (en) | 1983-06-22 | 1983-06-22 | Victor Wassilieff | CLOSING DEVICE FOR FLUID CONTAINERS. |
| US4859610A (en) | 1985-06-05 | 1989-08-22 | Synbiotics Corporation | Immunoassay incubation device |
| US4703865A (en) * | 1985-06-10 | 1987-11-03 | Bates William T D | Sealing cap |
| US4933291A (en) | 1986-12-22 | 1990-06-12 | Eastman Kodak Company | Centrifugable pipette tip and pipette therefor |
| US5089417A (en) | 1987-07-01 | 1992-02-18 | Miles Inc. | Fluid separation and processing device |
| US4849173A (en) | 1987-07-24 | 1989-07-18 | Chang Mao Kuei | Excrement examination unit |
| US5597733A (en) | 1988-07-25 | 1997-01-28 | Precision Systems, Inc. | Automatic multiple-sample multiple-reagent dispensing method in chemical analyzer |
| US5160702A (en) * | 1989-01-17 | 1992-11-03 | Molecular Devices Corporation | Analyzer with improved rotor structure |
| US5026526A (en) | 1990-02-09 | 1991-06-25 | Eastman Kodak Company | Automated capping means for analyzer pipette |
| GB9013728D0 (en) | 1990-06-20 | 1990-08-08 | Waddington & Duval Ltd | Improvements in and relating to dispensing taps |
| US5179862A (en) | 1990-06-29 | 1993-01-19 | Panametrics, Inc. | Snap-on flow measurement system |
| US6013532A (en) | 1990-09-26 | 2000-01-11 | Immunivest Corporation | Methods for magnetic immobilization and manipulation of cells |
| JPH0726701Y2 (en) | 1991-03-08 | 1995-06-14 | 東洋製罐株式会社 | Sample collection container |
| US5149506A (en) | 1991-08-09 | 1992-09-22 | Sage Products, Inc. | Stool collection and transport device |
| US5242660A (en) * | 1992-02-28 | 1993-09-07 | Paul Hsei | Sample preparation device |
| US5427739A (en) * | 1992-08-27 | 1995-06-27 | Schering-Plough Healthcare Products, Inc. | Apparatus for performing immunoassays |
| US5302348A (en) | 1992-12-10 | 1994-04-12 | Itc Corporation | Blood coagulation time test apparatus and method |
| US5578269A (en) | 1993-06-11 | 1996-11-26 | Ortho Diagnostic Systems Inc. | Automated blood analysis system with an integral centrifuge |
| US5658801A (en) | 1994-05-03 | 1997-08-19 | Spectral Diagnostics Inc. | Medical test kit |
| DE4420719C2 (en) | 1994-06-15 | 1997-11-20 | Henkel Kgaa | Membrane-sealed tube with needle lock |
| ES2168389T3 (en) * | 1994-09-08 | 2002-06-16 | Lifescan Inc | STRIP OF OPTICAL READING AND INCORPORATED PATTERN FOR THE DETECTION OF AN ANALYTE. |
| US5504011A (en) | 1994-10-21 | 1996-04-02 | International Technidyne Corporation | Portable test apparatus and associated method of performing a blood coagulation test |
| US5728352A (en) * | 1994-11-14 | 1998-03-17 | Advanced Care Products | Disposable electronic diagnostic instrument |
| US5882942A (en) | 1995-02-15 | 1999-03-16 | Wako Pure Chemical Industries, Ltd. | Method for sampling feces |
| US5814275A (en) | 1995-02-15 | 1998-09-29 | Akzo Nobel N.V. | Obstruction detector for a fluid flow line of a medical laboratory instrument |
| EP0920627B1 (en) | 1996-06-07 | 2004-05-12 | Immunivest Corporation | Magnetic separation employing external and internal gradients |
| US5714123A (en) | 1996-09-30 | 1998-02-03 | Lifescan, Inc. | Protective shield for a blood glucose strip |
| US5772966A (en) | 1997-01-24 | 1998-06-30 | Maracas; George N. | Assay dispensing apparatus |
| US6342183B1 (en) | 1997-02-14 | 2002-01-29 | Escreen | System for collecting and locally analyzing a fluid specimen |
| US5958349A (en) | 1997-02-28 | 1999-09-28 | Cepheid | Reaction vessel for heat-exchanging chemical processes |
| US6002475A (en) * | 1998-01-28 | 1999-12-14 | Careside, Inc. | Spectrophotometric analytical cartridge |
| US6271046B1 (en) * | 1997-10-06 | 2001-08-07 | Enterix, Inc. | Apparatus and method for analyte detection |
| US6184040B1 (en) * | 1998-02-12 | 2001-02-06 | Polaroid Corporation | Diagnostic assay system and method |
| US6391264B2 (en) * | 1999-02-11 | 2002-05-21 | Careside, Inc. | Cartridge-based analytical instrument with rotor balance and cartridge lock/eject system |
| US6239445B1 (en) * | 1999-03-01 | 2001-05-29 | Bayer Corporation | Optical inspection apparatus with removable inserts |
| US7011794B2 (en) * | 2002-11-25 | 2006-03-14 | Immunivest Corporation | Upon a cartridge for containing a specimen sample for optical analysis |
-
2002
- 2002-02-12 AT AT02709486T patent/ATE340360T1/en not_active IP Right Cessation
- 2002-02-12 WO PCT/US2002/004124 patent/WO2002065103A1/en active IP Right Grant
- 2002-02-12 EP EP02709486A patent/EP1360471B1/en not_active Expired - Lifetime
- 2002-02-12 CA CA2434604A patent/CA2434604C/en not_active Expired - Fee Related
- 2002-02-12 AU AU2002243968A patent/AU2002243968B2/en not_active Ceased
- 2002-02-12 DE DE60214827T patent/DE60214827T2/en not_active Expired - Lifetime
- 2002-02-12 JP JP2002564572A patent/JP3766064B2/en not_active Expired - Fee Related
- 2002-02-12 CN CNA02804875XA patent/CN1491355A/en active Pending
- 2002-02-12 IL IL15674102A patent/IL156741A0/en unknown
- 2002-02-12 BR BR0207095-2A patent/BR0207095A/en not_active IP Right Cessation
- 2002-02-12 CA CA2708573A patent/CA2708573C/en not_active Expired - Fee Related
- 2002-02-12 KR KR10-2003-7010548A patent/KR20030074816A/en not_active Application Discontinuation
- 2002-02-12 US US10/074,900 patent/US6861259B2/en not_active Expired - Lifetime
-
2004
- 2004-11-12 US US10/988,057 patent/US7604777B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1360471A1 (en) | 2003-11-12 |
| KR20030074816A (en) | 2003-09-19 |
| CN1491355A (en) | 2004-04-21 |
| EP1360471A4 (en) | 2005-02-23 |
| EP1360471B1 (en) | 2006-09-20 |
| DE60214827T2 (en) | 2007-03-29 |
| US7604777B2 (en) | 2009-10-20 |
| ATE340360T1 (en) | 2006-10-15 |
| US20050063863A1 (en) | 2005-03-24 |
| AU2002243968A2 (en) | 2002-08-28 |
| CA2434604C (en) | 2010-09-28 |
| US20020109838A1 (en) | 2002-08-15 |
| JP3766064B2 (en) | 2006-04-12 |
| IL156741A0 (en) | 2004-02-08 |
| US6861259B2 (en) | 2005-03-01 |
| DE60214827D1 (en) | 2006-11-02 |
| CA2708573C (en) | 2012-05-01 |
| JP2004526955A (en) | 2004-09-02 |
| BR0207095A (en) | 2004-01-20 |
| AU2002243968B2 (en) | 2007-01-25 |
| WO2002065103A1 (en) | 2002-08-22 |
| CA2708573A1 (en) | 2002-08-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2434604A1 (en) | Cartridge for containing a specimen sample for optical analysis | |
| CA2507549A1 (en) | Improvement upon a cartridge for containing a specimen sample for optical analysis | |
| US5341692A (en) | Device for taking, preserving and transporting a fluid sample for analysis | |
| AU2002243968A1 (en) | Cartridge for containing a specimen sample for optical analysis | |
| US7029627B2 (en) | Apparatus for sampling, storing, preserving and testing a specimen | |
| JP4774210B2 (en) | Gathering assembly | |
| ES2316362T3 (en) | EXCHANGE OF FLUIDS IN A CAMERA ON A MICROSCOPE SLIDE HOLDER. | |
| WO2005023426A3 (en) | Biological specimen collection and analysis system | |
| CN101389965A (en) | Rapid test apparatus | |
| BR112015027553B1 (en) | assembly to prepare a specimen to determine the presence of at least one species of microorganism in the specimen and method for preparing a specimen to determine the presence of at least one species of microorganism in the specimen | |
| US4660423A (en) | Water sampling apparatus | |
| US4594905A (en) | Liquid analyzer | |
| US20020057996A1 (en) | Centrifuge tube assembly | |
| AU2013285517B2 (en) | Device for spermatozoa selection | |
| CN207751723U (en) | A kind of fracturing fluid positioning and quantitative sampler | |
| RU2249693C1 (en) | Sample-taking container | |
| CA2405257A1 (en) | Air tight bailer system | |
| JPS59203976A (en) | Sealing device for needle part of liquid sampling vessel | |
| CA2425624A1 (en) | Apparatus for sampling and testing a specimen | |
| CA3232433A1 (en) | Dual chamber specimen collection container assembly | |
| ECSP003369A (en) | TESTED TAPE HAVING A LIQUID CELL AND METHOD TESTING A SAMPLE |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20210831 |
|
| MKLA | Lapsed |
Effective date: 20200212 |