CA2436342A1 - Coated vascular filters - Google Patents
Coated vascular filters Download PDFInfo
- Publication number
- CA2436342A1 CA2436342A1 CA002436342A CA2436342A CA2436342A1 CA 2436342 A1 CA2436342 A1 CA 2436342A1 CA 002436342 A CA002436342 A CA 002436342A CA 2436342 A CA2436342 A CA 2436342A CA 2436342 A1 CA2436342 A1 CA 2436342A1
- Authority
- CA
- Canada
- Prior art keywords
- moiety
- vascular filter
- implantation
- living organism
- polymerized residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06166—Sutures
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1075—Balloon catheters with special features or adapted for special applications having a balloon composed of several layers, e.g. by coating or embedding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
Abstract
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
Claims (33)
1. A vascular filter for implantation into a living organism comprising:
a substantially tubular body formed from a plurality of longitudinally arranged first elements and a plurality of second elements connected to the plurality of first elements and to each other, the plurality of second elements forming a lattice structure for capturing particulate matter;
a biocompatible vehicle affixed to at least a portion of the substantially tubular body; and at least one agent in therapeutic dosages incorporated into the biocompatible vehicle for the treatment of a disease condition.
a substantially tubular body formed from a plurality of longitudinally arranged first elements and a plurality of second elements connected to the plurality of first elements and to each other, the plurality of second elements forming a lattice structure for capturing particulate matter;
a biocompatible vehicle affixed to at least a portion of the substantially tubular body; and at least one agent in therapeutic dosages incorporated into the biocompatible vehicle for the treatment of a disease condition.
2. The vascular filter for implantation into a living organism according to Claim 1, wherein the biocompatible vehicle comprises a polymeric matrix.
3. The vascular filter for implantation into a living organism according to Claim 2, wherein the polymeric matrix comprises poly(ethylene-co-vinytacetate) and polybutylmethacrylate.
4. The vascular filter for implantation into a living organism according to Claim 3, wherein the polymeric matrix comprises first and second layers, the first layer making contact with at least a portion of the substantially tubular body and comprising a solution of polyethylene-co-vinylacetate) and polybutylmethacrylate, and the second layer comprising polybutylmethacrylate.
5. The vascular filter for implantation into a living organism according to Claim 4, wherein the at least one agent is incorporated into the first layer.
6. The vascular filter for implantation into a living organism according to Claim 2, wherein the biocompatible vehicle comprises a polyfluoro copolymer comprising polymerized residue of a first moiety selected from the group consisting of vinylidenefluoride and tetrafluoroethylene, and polymerized residue of a second moiety other than the first moiety and which is copolymerized with the first moiety, thereby producing the polyfluoro copolymer, wherein the relative amounts of the polymerized residue of the first moiety and the polymerized residue of the second moiety are effective to produce the biocompatible vehicle with properties effective for use in coating implantable medical devices when the coated medical device is subjected to a predetermined maximum temperature, and a solvent in which the polyfluoro copolymer is substantially soluble.
7. The vascular filter for implantation into a living organism according to Claim 6, wherein the polyfluoro copolymer comprises from about fifty to about ninety-two weight percent of the polymerized residue of the first moiety copolymerized with from about fifty to about eight weight percent of the polymerized residue of the second moiety.
8. The vascular filter for implantation into a living organism according to Claim 6, wherein said polyfluoro copolymer comprises from about fifty to about eighty-five weight percent of the polymerized residue of vinylidenefluoride copolymerized with from about fifty to about fifteen weight percent of the polymerized residue of the second moiety.
9. The vascular filter for implantation into a living organism according to Claim 6, wherein said copolymer comprises from about fifty-five to about sixty-five weight percent of the polymerized residue of the vinylidenefluoride copolymerized with from about forty-five to about thirty-five weight percent of the polymerized residue of the second moiety.
10. The vascular filter for implantation into a living organism according to Claim 6, wherein the second moiety is selected from the group consisting of hexafluoropropylene, tetrafluoroethylene, vinylidenefluoride, 1-hydropentafluoropropylene, perfluoro (methyl vinyl ether), chlorotrifluoroethylene, pentafluoropropene, trifluoroethylene, hexafluoroacetone and hexsafluoroisobutylene.
11. The vascular filter for implantation into a living organism according to Claim 6, wherein the second moiety is hexafluoropropylene.
12. The vascular filter for implantation into a living organism according to Claim 1, wherein the at least one agent comprises an anti-proliferative.
13. The vascular filter for implantation into a living organism according to Claim 1, wherein the at least one agent comprises an anti-inflammatory.
14. The vascular filter for implantation into a living organism according to Claim 1, wherein the at least one agent comprises an anti-coagulant.
15. The vascular filter for implantation into a living organism according to Claim 1, wherein the at least one agent comprises rapamycin.
16. The vascular filter for implantation into a living organism according to Claim 1, wherein the at least one agent comprises heparin.
17. A removable percutaneous vascular filter system for blocking micro-and macro-emboli in a vessel while allowing continued perfusion of blood, comprising:
a guidewire having distal and proximal ends;
a filter including a non-metallic, porous, flexible filter membrane having a distal portion and a proximal free portion and a filter membrane support structure extending from the flexible filter membrane distal portion to at least the flexible filter membrane proximal portion, wherein the filter membrane distal portion in pivotally attached to the guidewire near the distal end of the guidewire and wherein the filter membrane proximal free end portion is substantially parallel to the guidewire in its collapsed state;
deploying means operatively connected to the filter to cause the filter membrane proximal free end portion to move from a position substantially parallel to the guidewire to a position removed from the longitudinal axis of the guidewire to cause the flexible filter membrane to form a substantially conical shape to form a generally sealing relationship with the wall of the vessel;
a biocompatible vehicle affixed to at least a portion of the filter; and at least one agent in therapeutic dosages incorporated into the biocompatible vehicle for the treatment of a disease condition.
a guidewire having distal and proximal ends;
a filter including a non-metallic, porous, flexible filter membrane having a distal portion and a proximal free portion and a filter membrane support structure extending from the flexible filter membrane distal portion to at least the flexible filter membrane proximal portion, wherein the filter membrane distal portion in pivotally attached to the guidewire near the distal end of the guidewire and wherein the filter membrane proximal free end portion is substantially parallel to the guidewire in its collapsed state;
deploying means operatively connected to the filter to cause the filter membrane proximal free end portion to move from a position substantially parallel to the guidewire to a position removed from the longitudinal axis of the guidewire to cause the flexible filter membrane to form a substantially conical shape to form a generally sealing relationship with the wall of the vessel;
a biocompatible vehicle affixed to at least a portion of the filter; and at least one agent in therapeutic dosages incorporated into the biocompatible vehicle for the treatment of a disease condition.
18. The removable percutaneous vascular filter system according to Claim 17, wherein the biocompatible vehicle comprises a polymeric matrix.
19. The removable percutaneous vascular filter system according to Claim 18, wherein the polymeric matrix comprises poly(ethylene-co-vinylacetate) and polybutylmethacrylate.
20. The removable percutaneous vascular filter system according to Claim 19, wherein the polymeric matrix comprises first and second layers, the first layer making contact with at least a portion of the filter and comprising a solution of poly(ethylene-co-vinylacetate) and polybutylmethacrylate and the second layer comprising polybutylmethacrylate.
21. The removable percutaneous vascular filter system according to Claim 20, wherein the at least one agent is incorporated into the first layer.
22. The removable percutaneous vascular filter system according to Claim 18, wherein the biocompatible vehicle comprises a polyfluoro copolymer comprising polymerized residue of a first moiety selected from the group consisting of vinylidenefluoride and tetrafluoroethylene, and polymerized residue of a second moiety other than the first moiety and which is copolymerized with the first moiety, thereby producing the polyfluoro copolymer, wherein the relative amounts of the polymerized residue of the first moiety and the polymerized residue of the second moiety are effective to produce the biocompatible vehicle with properties effective for use in coating implantable medical devices when the coated medical device is subjected to a predetermined maximum temperature, and a solvent in which the polyfluoro copolymer is substantially soluble.
23. The removable percutaneous vascular filter system according to Claim 22, wherein the polyfluoro copolymer comprises from about fifty to about ninety-two weight percent of the polymerized residue of the first moiety copolymerized with from about fifty to about eight weight percent of the polymerized residue of the second moiety.
24. The removable percutaneous vascular filter system according to Claim 22, wherein the polyfluoro copolymer comprises from about fifty to about eighty-five weight percent of the polymerized residue of vinylidenefluoride copolymerized with from about fifty to about fifteen weight percent of the polymerized residue of the second moiety.
25. The removable percutaneous vascular filter system according to Claim 22, wherein said copolymer comprises from about fifty-five to about sixty-five weight percent of the polymerized residue of the vinylidenefluoride copolymerized with from about forty-five to about thirty-five weight percent of the polymerized residue of the second moiety.
26. The removable percutaneous vascular filter system according to Claim 22, wherein the second moiety is selected from the group consisting of hexafluoropropylene, tetrafluoroethylene, vinylidenefluoride, 1-hydropentafluoropropylene, perfluoro (methyl vinyl ether), chlorotrifluoroethylene, pentafluoropropene, trifluoroethylene, hexafluoroacetone and hexafluoroisobutylene.
27. The removable percutaneous vascular flier system according to Claim 22, wherein the second moiety is hexafluoropropylene.
28. The removable percutaneous vascular filter system according to Claim 17, wherein the at least one agent comprises an anti-proliferative.
29. The removable percutaneous vascular filter system according to Claim 17, wherein the at least one agent comprises an anti-inflammatory.
30. The removable percutaneous vascular falter system according to Claim 17, wherein the at least one agent comprises an anti-coagulant.
31. The removable percutaneous vascular falter system according to Claim 17, wherein the at least one agent comprises rapamycin.
32. The removable percutaneous vascular filter system according to Claim 17, wherein the at least one agent comprises heparin.
33. The removable percutaneous vascular filter system according to Claim 17, wherein the at least one agent comprises dexamethasone.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US10/208,581 | 2002-07-30 | ||
US10/208,581 US20030204168A1 (en) | 2002-04-30 | 2002-07-30 | Coated vascular devices |
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Publication Number | Publication Date |
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CA2436342A1 true CA2436342A1 (en) | 2004-01-30 |
CA2436342C CA2436342C (en) | 2011-06-28 |
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Application Number | Title | Priority Date | Filing Date |
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CA2436342A Expired - Lifetime CA2436342C (en) | 2002-07-30 | 2003-07-30 | Coated vascular filters |
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US (1) | US20030204168A1 (en) |
EP (1) | EP1386624B1 (en) |
JP (1) | JP4368631B2 (en) |
AT (1) | ATE432096T1 (en) |
AU (1) | AU2003220715B2 (en) |
CA (1) | CA2436342C (en) |
DE (1) | DE60327730D1 (en) |
MX (1) | MXPA03006825A (en) |
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JP4368631B2 (en) | 2009-11-18 |
JP2004130101A (en) | 2004-04-30 |
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