CA2436618A1 - Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control - Google Patents

Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control Download PDF

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Publication number
CA2436618A1
CA2436618A1 CA002436618A CA2436618A CA2436618A1 CA 2436618 A1 CA2436618 A1 CA 2436618A1 CA 002436618 A CA002436618 A CA 002436618A CA 2436618 A CA2436618 A CA 2436618A CA 2436618 A1 CA2436618 A1 CA 2436618A1
Authority
CA
Canada
Prior art keywords
sample
block
instrument
computer
temperature control
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002436618A
Other languages
French (fr)
Other versions
CA2436618C (en
Inventor
Albert C. Mossa
Lisa M. Goven
Fenton Williams
Timothy M. Woudenberg
Marcel Margulies
Robert P. Ragusa
Richard Leath
John G. Atwood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Perkin-Elmer/Cetus Instruments
Albert C. Mossa
Lisa M. Goven
Fenton Williams
Timothy M. Woudenberg
Marcel Margulies
Robert P. Ragusa
Richard Leath
John G. Atwood
Cetus Corporation
The Perkin-Elmer Corporation
F. Hoffman-La Roche Ltd.
Pe Corporation (Ny)
Applera Corporation
Applied Biosystems Inc.
Applied Biosystems, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27088746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2436618(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Perkin-Elmer/Cetus Instruments, Albert C. Mossa, Lisa M. Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, John G. Atwood, Cetus Corporation, The Perkin-Elmer Corporation, F. Hoffman-La Roche Ltd., Pe Corporation (Ny), Applera Corporation, Applied Biosystems Inc., Applied Biosystems, Llc filed Critical Perkin-Elmer/Cetus Instruments
Publication of CA2436618A1 publication Critical patent/CA2436618A1/en
Application granted granted Critical
Publication of CA2436618C publication Critical patent/CA2436618C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D23/00—Control of temperature
    • G05D23/19—Control of temperature characterised by the use of electric means
    • G05D23/1927—Control of temperature characterised by the use of electric means using a plurality of sensors
    • G05D23/193—Control of temperature characterised by the use of electric means using a plurality of sensors sensing the temperaure in different places in thermal relationship with one or more spaces
    • G05D23/1935—Control of temperature characterised by the use of electric means using a plurality of sensors sensing the temperaure in different places in thermal relationship with one or more spaces using sequential control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D23/00—Control of temperature
    • G05D23/19—Control of temperature characterised by the use of electric means
    • G05D23/1917—Control of temperature characterised by the use of electric means using digital means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se

Abstract

An instrument for performing highly accurate PCR
employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A heated cover deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.
CA002436618A 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control Expired - Lifetime CA2436618C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62060690A 1990-11-29 1990-11-29
US07/620,606 1990-11-29
US67054591A 1991-03-14 1991-03-14
US07/670,545 1991-03-14
CA002395941A CA2395941C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002395941A Division CA2395941C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control

Publications (2)

Publication Number Publication Date
CA2436618A1 true CA2436618A1 (en) 1992-05-30
CA2436618C CA2436618C (en) 2007-09-18

Family

ID=27088746

Family Applications (4)

Application Number Title Priority Date Filing Date
CA002266010A Expired - Lifetime CA2266010C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
CA002436618A Expired - Lifetime CA2436618C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
CA002056743A Expired - Lifetime CA2056743C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
CA002395941A Expired - Lifetime CA2395941C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002266010A Expired - Lifetime CA2266010C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA002056743A Expired - Lifetime CA2056743C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
CA002395941A Expired - Lifetime CA2395941C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control

Country Status (14)

Country Link
US (4) US5475610A (en)
EP (8) EP0810030B2 (en)
JP (7) JPH06233670A (en)
KR (1) KR100236506B1 (en)
AT (6) ATE373107T1 (en)
AU (2) AU662494B2 (en)
CA (4) CA2266010C (en)
DE (11) DE69133376T2 (en)
DK (4) DK1452608T3 (en)
ES (3) ES2293111T3 (en)
GR (1) GR920300125T1 (en)
IE (2) IE914170A1 (en)
IL (5) IL100209A (en)
NZ (3) NZ240800A (en)

Families Citing this family (567)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7560273B2 (en) * 2002-07-23 2009-07-14 Applied Biosystems, Llc Slip cover for heated platen assembly
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5455175A (en) * 1990-06-04 1995-10-03 University Of Utah Research Foundation Rapid thermal cycling device
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US6787338B2 (en) 1990-06-04 2004-09-07 The University Of Utah Method for rapid thermal cycling of biological samples
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US5282543A (en) * 1990-11-29 1994-02-01 The Perkin Elmer Corporation Cover for array of reaction tubes
US6703236B2 (en) * 1990-11-29 2004-03-09 Applera Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
WO1992020778A1 (en) * 1991-05-24 1992-11-26 Kindconi Pty Limited Biochemical reaction control
US5947167A (en) * 1992-05-11 1999-09-07 Cytologix Corporation Dispensing assembly with interchangeable cartridge pumps
US6180061B1 (en) 1992-05-11 2001-01-30 Cytologix Corporation Moving platform slide stainer with heating elements
US20040191128A1 (en) * 1992-05-11 2004-09-30 Cytologix Corporation Slide stainer with heating
US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US6495676B1 (en) 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
CA2130517C (en) * 1993-09-10 1999-10-05 Walter Fassbind Array of reaction containers for an apparatus for automatic performance of temperature cycles
CA2130013C (en) * 1993-09-10 1999-03-30 Rolf Moser Apparatus for automatic performance of temperature cycles
JP3034954B2 (en) * 1993-10-22 2000-04-17 アボツト・ラボラトリーズ Reaction tubes and methods of use to minimize contamination
DE4409436A1 (en) * 1994-03-19 1995-09-21 Boehringer Mannheim Gmbh Process for processing nucleic acids
DE4412286A1 (en) * 1994-04-09 1995-10-12 Boehringer Mannheim Gmbh System for contamination-free processing of reaction processes
DE69519783T2 (en) * 1994-04-29 2001-06-07 Perkin Elmer Corp METHOD AND DEVICE FOR REAL-TIME DETECTION OF PRODUCTS OF NUCLEIC ACID AMPLIFICATION
US5456360A (en) * 1994-09-30 1995-10-10 The Perkin-Elmer Corporation Holder assembly for reaction tubes
DE4440294A1 (en) * 1994-11-11 1996-05-15 Boehringer Mannheim Gmbh System for the incubation of sample liquids
US5683659A (en) * 1995-02-22 1997-11-04 Hovatter; Kenneth R. Integral assembly of microcentrifuge strip tubes and strip caps
US5780222A (en) * 1995-04-10 1998-07-14 Alpha Therapeutic Corporation Method of PCR testing of pooled blood samples
DE19519015C1 (en) * 1995-05-24 1996-09-05 Inst Physikalische Hochtech Ev Miniaturised multi-chamber thermo-cycler for polymerase chain reaction
US5604130A (en) * 1995-05-31 1997-02-18 Chiron Corporation Releasable multiwell plate cover
JP3549621B2 (en) * 1995-06-09 2004-08-04 株式会社アイ・エイチ・アイ・エアロスペース Temperature limiting circuit
US5830657A (en) * 1996-05-01 1998-11-03 Visible Genetics Inc. Method for single-tube sequencing of nucleic acid polymers
US6063633A (en) * 1996-02-28 2000-05-16 The University Of Houston Catalyst testing process and apparatus
ATE318327T1 (en) 1996-06-04 2006-03-15 Univ Utah Res Found FLUORESCENCE-DONOR-ACCEPTOR PAIR
WO1998005060A1 (en) * 1996-07-31 1998-02-05 The Board Of Trustees Of The Leland Stanford Junior University Multizone bake/chill thermal cycling module
JPH10134941A (en) * 1996-10-29 1998-05-22 Ngk Insulators Ltd Ceramic heater
US5882903A (en) * 1996-11-01 1999-03-16 Sarnoff Corporation Assay system and method for conducting assays
DE19655141C5 (en) * 1996-11-08 2013-12-05 Eppendorf Ag Gradient tempering block for laboratory thermostats
DE29623597U1 (en) * 1996-11-08 1999-01-07 Eppendorf Geraetebau Netheler Temperature control block with temperature control devices
US5790437A (en) * 1996-11-26 1998-08-04 Watlow Electric Manufacturing Company Graphical interface for programming ramping controllers
US5779984A (en) * 1996-12-04 1998-07-14 Rainin Intstrumental Co., Inc. Pipette tip rack and refill pack containing large maximized volume freely nestable pipette tips
US5859699A (en) * 1997-02-07 1999-01-12 Arcturus Engineering, Inc. Laser capture microdissection analysis vessel
US6074868A (en) 1997-03-03 2000-06-13 Regents Of The University Of Minnesota Alumina plate method and device for controlling temperature
US6126904A (en) * 1997-03-07 2000-10-03 Argonaut Technologies, Inc. Apparatus and methods for the preparation of chemical compounds
AU743025B2 (en) 1997-03-12 2002-01-17 Applera Corporation DNA polymerases having improved labeled nucleotide incorporation properties
US7133726B1 (en) 1997-03-28 2006-11-07 Applera Corporation Thermal cycler for PCR
EP2913109A1 (en) * 1997-03-28 2015-09-02 Applera Corporation Assembly for thermal cycler for PCR
EP1127619B1 (en) * 1997-03-28 2003-10-08 PE Corporation (NY) Assembly for thermal cycler for PCR
EP1386666B1 (en) * 1997-03-28 2012-11-14 Life Technologies Corporation Improvements in thermal cycler for pcr
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
DE29714206U1 (en) * 1997-08-08 1997-12-11 Hoechst Marion Roussel De Gmbh Pipetting robot with improved temperature control device
PT895813E (en) * 1997-08-08 2004-11-30 Aventis Pharma Gmbh ROBOT OF PIPETACAO WITH TEMPERATURE IMPROVED ADJUSTMENT DEVICE
US6132684A (en) * 1997-10-31 2000-10-17 Becton Dickinson And Company Sample tube holder
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
AU747296B2 (en) * 1998-02-10 2002-05-16 Toyo Kohan Co. Ltd. Apparatus for immobilized DNA library preparation, apparatus for gene amplification, method for temperature control and method for comparing genes systematically
US6582962B1 (en) * 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
WO1999043434A1 (en) 1998-02-27 1999-09-02 Ventana Medical Systems, Inc. System and method of aspirating and dispensing reagent
US6183693B1 (en) 1998-02-27 2001-02-06 Cytologix Corporation Random access slide stainer with independent slide heating regulation
US6096271A (en) * 1998-02-27 2000-08-01 Cytologix Corporation Random access slide stainer with liquid waste segregation
US6369893B1 (en) 1998-05-19 2002-04-09 Cepheid Multi-channel optical detection system
US7188001B2 (en) * 1998-03-23 2007-03-06 Cepheid System and method for temperature control
ATE278471T1 (en) * 1998-05-04 2004-10-15 Hoffmann La Roche THERMOCYCLING APPARATUS WITH AN AUTOMATICALLY POSITIONABLE LID
DE69940574D1 (en) 1998-05-16 2009-04-23 Applera Corp Optical device, in particular for monitoring DNA polymerase chain reactions
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
US6818437B1 (en) * 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
US6149882A (en) * 1998-06-09 2000-11-21 Symyx Technologies, Inc. Parallel fixed bed reactor and fluid contacting apparatus
US7115231B1 (en) 1998-06-09 2006-10-03 Symyx Technologies, Inc. Parallel reactor with knife-edge seal
US6086831A (en) * 1998-06-10 2000-07-11 Mettler-Toledo Bohdan, Inc. Modular reaction block assembly with thermoelectric cooling and heating
US6780617B2 (en) 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
USD420743S (en) 1998-06-24 2000-02-15 Advanced Biotechnologies Limited Multi-well plate
CA2301153C (en) 1998-06-24 2008-08-26 Chen & Chen, Llc Fluid sample testing system
US7799521B2 (en) * 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
US6548026B1 (en) 1998-08-13 2003-04-15 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US6528026B2 (en) 1998-08-13 2003-03-04 Symyx Technologies, Inc. Multi-temperature modular reactor and method of using same
US6455316B1 (en) 1998-08-13 2002-09-24 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US6306658B1 (en) 1998-08-13 2001-10-23 Symyx Technologies Parallel reactor with internal sensing
US6890492B1 (en) 1998-08-13 2005-05-10 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US6759014B2 (en) * 2001-01-26 2004-07-06 Symyx Technologies, Inc. Apparatus and methods for parallel processing of multiple reaction mixtures
US6913934B2 (en) * 1998-08-13 2005-07-05 Symyx Technologies, Inc. Apparatus and methods for parallel processing of multiple reaction mixtures
US6413780B1 (en) 1998-10-14 2002-07-02 Abbott Laboratories Structure and method for performing a determination of an item of interest in a sample
US6906292B2 (en) * 1998-10-29 2005-06-14 Applera Corporation Sample tray heater module
US6896849B2 (en) * 1998-10-29 2005-05-24 Applera Corporation Manually-operable multi-well microfiltration apparatus and method
EP1000661A1 (en) * 1998-10-29 2000-05-17 Hans-Knöll-Institut für Naturstoff-Forschung e.v. Ultrathin-walled multiwell plate for heat block thermocycling
US20040214315A1 (en) * 1998-10-29 2004-10-28 Analytik Jena Ag Ultrathin-walled multi-well plate for heat block thermocycling
US6159368A (en) 1998-10-29 2000-12-12 The Perkin-Elmer Corporation Multi-well microfiltration apparatus
US6193064B1 (en) * 1998-11-04 2001-02-27 J. G. Finneran Associates, Inc. Multi-tier vial plate
SG81941A1 (en) * 1998-11-12 2001-07-24 Univ Singapore Device and method of concentration of samples by microcrystallization
US6372484B1 (en) 1999-01-25 2002-04-16 E.I. Dupont De Nemours And Company Apparatus for integrated polymerase chain reaction and capillary electrophoresis
CA2261326A1 (en) * 1999-02-09 2000-08-09 Jean-Pascal Viola Laboratory cap and well for hanging-drop crystallization methods
US6171850B1 (en) 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
AU756982B2 (en) 1999-03-19 2003-01-30 Life Technologies Corporation Multi-through hole testing plate for high throughput screening
EP1045038A1 (en) * 1999-04-08 2000-10-18 Hans-Knöll-Institut Für Naturstoff-Forschung E.V. Rapid heat block thermocycler
US20050279949A1 (en) * 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7423750B2 (en) * 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US7387891B2 (en) * 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
AU754172B2 (en) * 1999-05-27 2002-11-07 Applera Corporation Apparatus and method for the precise location of reaction plates
US6472186B1 (en) 1999-06-24 2002-10-29 Andre Quintanar High speed process and apparatus for amplifying DNA
IL147227A0 (en) * 1999-07-02 2002-08-14 Clondiag Chip Tech Gmbh Microchip matrix device for duplicating and characterizing nucleic acids
US6529796B1 (en) 1999-07-21 2003-03-04 Caco Pacific Corporation Closed loop interactive controller
US6340589B1 (en) 1999-07-23 2002-01-22 Mj Research, Inc. Thin-well microplate and methods of making same
EP1464401B1 (en) * 1999-07-30 2006-09-13 Bio-Rad Laboratories, Inc. Temperature control for multi-vessel reaction apparatus
US6657169B2 (en) 1999-07-30 2003-12-02 Stratagene Apparatus for thermally cycling samples of biological material with substantial temperature uniformity
AU2003200514B2 (en) * 1999-07-30 2004-05-06 Bio-Rad Laboratories, Inc. Temperature control for multi-vessel reaction apparatus
US6337435B1 (en) * 1999-07-30 2002-01-08 Bio-Rad Laboratories, Inc. Temperature control for multi-vessel reaction apparatus
US6633785B1 (en) 1999-08-31 2003-10-14 Kabushiki Kaisha Toshiba Thermal cycler and DNA amplifier method
JP2001136954A (en) * 1999-08-31 2001-05-22 Toshiba Corp Device for treating nucleic acid and method for treating nucleic acid
NL1012996C2 (en) * 1999-09-08 2001-03-12 Micronic B V Sealing mat for sealing test tubes.
DE19943187B4 (en) * 1999-09-09 2006-05-04 Kendro Laboratory Products Gmbh Method for treating sample material in a sample vessel and device
DE19946427C2 (en) * 1999-09-28 2002-07-04 Lange Gmbh Dr Bruno Method and device for the defined simultaneous heat treatment of several sample containers
EP1088590B1 (en) * 1999-09-29 2003-04-16 Tecan Trading AG Thermocycling device and hoisting element for microtitre plate
DE29917313U1 (en) 1999-10-01 2001-02-15 Mwg Biotech Ag Device for carrying out chemical or biological reactions
US6403931B1 (en) * 1999-10-07 2002-06-11 Ventana Medical Systems, Inc. Slide heater calibrator and temperature converter apparatus and method
WO2001025866A1 (en) * 1999-10-07 2001-04-12 Mecour Temperature Control, Llc System for controlling laboratory sample temperature and a ther mal tray for use in such system
US6300124B1 (en) 1999-11-02 2001-10-09 Regents Of The University Of Minnesota Device and method to directly control the temperature of microscope slides
US7033840B1 (en) 1999-11-09 2006-04-25 Sri International Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries
AU1476601A (en) * 1999-11-09 2001-06-06 Sri International Array for the high-throughput synthesis, screening and characterization of combinatorial libraries, and methods for making the array
AU1655901A (en) 1999-11-12 2001-06-06 E.I. Du Pont De Nemours And Company Fluorometer with low heat-generating light source
US6852986B1 (en) * 1999-11-12 2005-02-08 E. I. Du Pont De Nemours And Company Fluorometer with low heat-generating light source
EP1921440A3 (en) 1999-11-12 2008-06-04 E.I. Dupont De Nemours And Company Fluorometer with low heat-generating light source
JP4169511B2 (en) 1999-11-26 2008-10-22 東京理化器械株式会社 Sample temperature controller
DE10002920A1 (en) * 2000-01-19 2001-07-26 Epigenomics Ag Device for contacting biological material immobilized on surface with solution of second biological material, especially hybridization of DNA samples, comprises a cavity receiving solution with cover which has seal around its edges
US7169355B1 (en) 2000-02-02 2007-01-30 Applera Corporation Apparatus and method for ejecting sample well trays
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
CA2400644C (en) 2000-02-18 2009-07-14 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
WO2001081619A2 (en) * 2000-04-22 2001-11-01 Borros Arneth Conductivity pcr
US6994827B2 (en) * 2000-06-03 2006-02-07 Symyx Technologies, Inc. Parallel semicontinuous or continuous reactors
DE10066211B4 (en) * 2000-06-08 2008-06-26 Eppendorf Ag microtiter plate
US7347977B2 (en) 2000-06-08 2008-03-25 Eppendorf Ag Microtitration plate
DE10028536B4 (en) * 2000-06-08 2004-08-19 Eppendorf Ag microtiter plate
DE10066431B4 (en) * 2000-06-08 2013-10-24 Eppendorf Ag Micro-titer plate used for growing microorganisms or cells comprises frame made from rigid first plastic having plate with holes, and number of vessels made from second plastic with oxygen permeability connected to plate
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
EP2316569A1 (en) * 2000-06-28 2011-05-04 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
AU2000270385A1 (en) * 2000-08-22 2002-03-04 Bionex, Inc. Thermal cycler
US6640891B1 (en) 2000-09-05 2003-11-04 Kevin R. Oldenburg Rapid thermal cycling device
US7025120B2 (en) * 2000-09-05 2006-04-11 Oldenburg Kevin R Rapid thermal cycling device
DE10046224A1 (en) * 2000-09-19 2002-03-28 Merck Patent Gmbh Unit for parallel incubation of solutions includes frame holding titration plate closely against cover plate, forming tight seal
US6660232B1 (en) * 2000-09-29 2003-12-09 Promega Corporation Multi-well assay plate and plate holder and method of assembling the same
US7727479B2 (en) 2000-09-29 2010-06-01 Applied Biosystems, Llc Device for the carrying out of chemical or biological reactions
AU2002226050A1 (en) * 2000-12-12 2002-06-24 3-Dimensional Pharmaceuticals, Inc. Microtiter plate with integral heater
WO2002049761A2 (en) * 2000-12-18 2002-06-27 Protedyne Corporation Automated laboratory system and method
US8898021B2 (en) * 2001-02-02 2014-11-25 Mark W. Perlin Method and system for DNA mixture analysis
US20020165675A1 (en) * 2001-03-03 2002-11-07 Golovlev Valeri V. Method and microelectronic device for multi-site molecule detection
WO2002078229A1 (en) * 2001-03-21 2002-10-03 Stine John A An access and routing protocol for ad hoc networks using synchronous collision resolution and node state dissemination
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US6692708B2 (en) * 2001-04-05 2004-02-17 Symyx Technologies, Inc. Parallel reactor for sampling and conducting in situ flow-through reactions and a method of using same
US7440684B2 (en) * 2001-04-12 2008-10-21 Spaid Michael A Method and apparatus for improved temperature control in microfluidic devices
GB0110449D0 (en) * 2001-04-28 2001-06-20 Genevac Ltd Improvements in and relating to the heating of microtitre well plates in centrifugal evaporators
GB0110501D0 (en) 2001-04-30 2001-06-20 Secr Defence Brit Amplification process
GB0111275D0 (en) 2001-05-09 2001-06-27 Secr Defence Analytical method and kit
CA2348042A1 (en) 2001-06-04 2002-12-04 Ann Huletsky Sequences for detection and identification of methicillin-resistant staphylococcus aureus
US6825927B2 (en) * 2001-06-15 2004-11-30 Mj Research, Inc. Controller for a fluorometer
US6838052B2 (en) * 2001-06-29 2005-01-04 Symyx Technologies, Inc. In-situ injection and materials screening device
US6514750B2 (en) * 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
US20040166569A1 (en) * 2001-07-13 2004-08-26 Andre Marziali Thermal cycling methods and apparatus
AU2002319595B2 (en) * 2001-07-20 2007-06-07 Gen-Probe Incorporated Sample carrier and drip shield for use therewith
GB0121827D0 (en) * 2001-09-10 2001-10-31 Bjs Company Ltd Zone heating of specimen carriers
CN1262351C (en) 2001-09-11 2006-07-05 伊库姆有限公司 Sample vessels
US20050042629A1 (en) 2002-09-13 2005-02-24 Applera Corporation Thermus scotoductus nucleic acid polymerases
PL367715A1 (en) * 2001-09-20 2005-03-07 3-Dimensional Pharmaceuticals, Inc. Conductive microtiter plate
US7459302B2 (en) 2001-10-02 2008-12-02 Stratagene California Side-wall heater for thermocycler device
US7363168B2 (en) * 2001-10-02 2008-04-22 Stratagene California Adaptive baseline algorithm for quantitative PCR
US20030072685A1 (en) * 2001-10-11 2003-04-17 Goldman Jeffrey A. Heat conducting sample block
US20080124717A1 (en) * 2001-10-12 2008-05-29 Scott Manalis Method and apparatus for label-free electronic real-time double-stranded nucleic acid detection
US6765490B2 (en) * 2001-10-23 2004-07-20 Steven W. Lopez System and methods for detecting harmful agents within contents of mail
US7635588B2 (en) * 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
US7052877B2 (en) 2001-11-30 2006-05-30 Applera Corporation Thermus brockianus nucleic acid polymerases
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US7614444B2 (en) 2002-01-08 2009-11-10 Oldenburg Kevin R Rapid thermal cycling device
US7373968B2 (en) * 2002-01-08 2008-05-20 Kevin R. Oldenburg Method and apparatus for manipulating an organic liquid sample
WO2003061832A1 (en) * 2002-01-16 2003-07-31 Robbins Scientific Corporation Low volume micro-plate and volume-limiting plugs
US7228237B2 (en) 2002-02-07 2007-06-05 Applera Corporation Automatic threshold setting and baseline determination for real-time PCR
US6818420B2 (en) * 2002-02-27 2004-11-16 Biosource International, Inc. Methods of using FET labeled oligonucleotides that include a 3′-5′ exonuclease resistant quencher domain and compositions for practicing the same
US20050266455A1 (en) * 2002-03-02 2005-12-01 Sci Tec, Inc. Method and microelectronic device for multi-site molecule detection
KR100459896B1 (en) * 2002-03-06 2004-12-04 삼성전자주식회사 Thermostatic control Method and apparatus for Driving a PCR(polymerize chain reaction) chip
US20040241723A1 (en) * 2002-03-18 2004-12-02 Marquess Foley Leigh Shaw Systems and methods for improving protein and milk production of dairy herds
DE10243209A1 (en) * 2002-03-22 2003-10-02 Endress & Hauser Wetzer Gmbh Device for cooling sampling unit comprises container for receiving sample bottle and/or sample container arranged in sampling unit, cooling unit and vaporizer
US11249095B2 (en) 2002-04-15 2022-02-15 Ventana Medical Systems, Inc. Automated high volume slide processing system
CA2482441C (en) 2002-04-15 2010-06-22 Ventana Medical Systems, Inc. Automated high volume slide staining system
US7468161B2 (en) 2002-04-15 2008-12-23 Ventana Medical Systems, Inc. Automated high volume slide processing system
US20030211595A1 (en) * 2002-05-13 2003-11-13 Lee Tzong Hae Rack for handling polymerase chain reaction tubes
JP4235170B2 (en) 2002-05-17 2009-03-11 ジェン−プロウブ インコーポレイテッド Sample carrier with detachable locking mechanism
AU2003239485B2 (en) * 2002-05-17 2008-11-20 Gen-Probe Incorporated Sample carrier having sample tube blocking means and drip shield for use therewith
WO2003098278A2 (en) * 2002-05-17 2003-11-27 Applera Corporation Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
KR20050037991A (en) * 2002-05-20 2005-04-25 노드롭 그루만 코포레이션 Automatic point source biological agent detection system
US20030219890A1 (en) * 2002-05-21 2003-11-27 Gordon Gary B. Probe array bio-analysis by centrifuging shallow reaction cell
EP1532273A4 (en) * 2002-06-20 2009-11-18 Primera Biosystems Inc Apparatus for polynucleotide detection and quantitation
US7083974B2 (en) * 2002-07-12 2006-08-01 Applera Corporation Rotatable sample disk and method of loading a sample disk
DE10232202B4 (en) * 2002-07-16 2005-08-25 H+P Labortechnik Ag Sample treatment station
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
US20040043494A1 (en) * 2002-08-30 2004-03-04 Amorese Douglas A. Apparatus for studying arrays
WO2005058501A1 (en) * 2002-09-09 2005-06-30 Bjs Company Ltd Heating samples in specimen carriers
EP1546386A4 (en) * 2002-09-17 2006-05-10 Pharmacia Corp Preservation of rna and reverse transcriptase during automated liquid handling
US6730883B2 (en) 2002-10-02 2004-05-04 Stratagene Flexible heating cover assembly for thermal cycling of samples of biological material
JP2006505283A (en) * 2002-11-08 2006-02-16 フアルマシア・コーポレーシヨン High-speed automated nucleic acid isolation and quantification method
EP1581445A4 (en) * 2002-11-08 2009-04-22 Irm Llc Systems and methods of sorting samples
US6905076B2 (en) * 2002-11-15 2005-06-14 Advanced Research And Technology Institute, Inc. High temperature incubation system and method for small volumes
GB0226863D0 (en) * 2002-11-19 2002-12-24 Biogene Ltd Improvements in and relating to reaction vessels and reaction apparatus for use with such vessels
GB0229410D0 (en) * 2002-12-17 2003-01-22 Molecular Sensing Plc Sample vessel
WO2004074818A2 (en) 2002-12-20 2004-09-02 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US8676383B2 (en) 2002-12-23 2014-03-18 Applied Biosystems, Llc Device for carrying out chemical or biological reactions
US20070184548A1 (en) * 2002-12-23 2007-08-09 Lim Hi Tan Device for carrying out chemical or biological reactions
US8641987B2 (en) 2003-01-24 2014-02-04 Applied Biosystems, Llc Sample chamber array and method for processing a biological sample
AU2004220626B2 (en) 2003-02-05 2010-07-29 Iquum Inc. Sample processing tubule
CA2457607A1 (en) * 2003-02-12 2004-08-12 Agroterra Biotech Inc. Method of mutagenic chain reaction
US7332348B2 (en) * 2003-02-28 2008-02-19 Applera Corporation Sample substrate having a divided sample chamber and method of loading thereof
CN100439515C (en) * 2003-03-03 2008-12-03 清华大学 Laboratory nucleic acid analyzing chip system and its application
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
EP2390352A1 (en) 2003-03-18 2011-11-30 Quantum Genetics Ireland Limited Systems and methods for improving protein and milk production of dairy herds
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
CN1280428C (en) * 2003-05-19 2006-10-18 清华大学 Biochip system based on minute particle and its application
US20040258563A1 (en) * 2003-06-23 2004-12-23 Applera Corporation Caps for sample wells and microcards for biological materials
EP1654066B1 (en) 2003-07-31 2014-11-12 Handylab, Inc. Processing particle-containing samples
DE10341874A1 (en) * 2003-09-05 2005-03-31 Congen Biotechnologie Gmbh Method for the validation of thermocyclers
US20050053950A1 (en) * 2003-09-08 2005-03-10 Enrique Zudaire Ubani Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons
US7233393B2 (en) * 2004-08-05 2007-06-19 Applera Corporation Signal noise reduction for imaging in biological analysis
US20050280811A1 (en) * 2003-09-19 2005-12-22 Donald Sandell Grooved high density plate
CA2485049A1 (en) * 2003-10-17 2005-04-17 Russell G. Attridge, Jr. Thermal balance temperature control system
US7122799B2 (en) * 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
US8696993B2 (en) * 2003-12-25 2014-04-15 Arkray, Inc. Method of raising temperature of received object, and analyzing device
AU2005244673B2 (en) 2004-02-19 2009-12-10 The Governors Of The University Of Alberta Leptin promoter polymorphisms and uses thereof
CA2559171A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
GB0406015D0 (en) * 2004-03-17 2004-04-21 Dynal Biotech Asa Improvements in magnetic polymer particles
JP4592060B2 (en) 2004-04-26 2010-12-01 キヤノン株式会社 PCR amplification reaction apparatus and PCR amplification reaction method using the apparatus
US20080118955A1 (en) * 2004-04-28 2008-05-22 International Business Machines Corporation Method for precise temperature cycling in chemical / biochemical processes
US20050244933A1 (en) * 2004-04-28 2005-11-03 International Business Machines Corporation Method and apparatus for precise temperature cycling in chemical/biochemical processes
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US7659109B2 (en) * 2004-05-17 2010-02-09 Applied Biosystems, Llc Pasting edge heater
DE102004024350A1 (en) * 2004-05-17 2005-12-15 H+P Labortechnik Ag Reaction vessel and its preparation and use
US7311794B2 (en) 2004-05-28 2007-12-25 Wafergen, Inc. Methods of sealing micro wells
US20050282270A1 (en) * 2004-06-21 2005-12-22 Applera Corporation System for thermally cycling biological samples with heated lid and pneumatic actuator
EP1618954A1 (en) * 2004-07-14 2006-01-25 Corus Staal BV Steel sample tube
DE102004037341C5 (en) * 2004-08-02 2008-06-19 Dionex Softron Gmbh Apparatus for refrigerated storage and dispensing of samples for an integrated liquid cooling unit
US20060024204A1 (en) * 2004-08-02 2006-02-02 Oldenburg Kevin R Well plate sealing apparatus and method
US20060105453A1 (en) 2004-09-09 2006-05-18 Brenan Colin J Coating process for microfluidic sample arrays
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
DE602005015245D1 (en) * 2004-11-02 2009-08-13 Koninkl Philips Electronics Nv TEMPERATURE CONTROL SYSTEM AND METHOD
US7799283B2 (en) * 2004-11-12 2010-09-21 Ortho-Clinical Diagnostics, Inc. Heating and cooling multiple containers or multi-chamber containers
JP4756880B2 (en) * 2005-03-02 2011-08-24 キヤノン株式会社 PCR reaction temperature controller
US20060223075A1 (en) * 2005-03-29 2006-10-05 Exagen Diagnostics, Inc. Unique sequence hybridization probes (USP)
ES2401437T3 (en) * 2005-04-04 2013-04-19 Roche Diagnostics Gmbh Thermocycling of a block comprising multiple samples
US7910067B2 (en) 2005-04-19 2011-03-22 Gen-Probe Incorporated Sample tube holder
US20060257907A1 (en) * 2005-04-19 2006-11-16 The Regents Of The University Of California Packed bed for nucleic acid capture and amplification
WO2006124512A2 (en) * 2005-05-13 2006-11-23 Applera Corporation Low-mass thermal cycling block
DE102005027407B3 (en) * 2005-06-13 2006-11-09 Eppendorf Ag Thermo cycler, for polymerase chain reactions, comprises a cover over the holding zone for the reaction vessels with a sealing wall adjusted longitudinally by an external setting unit
US20070003443A1 (en) * 2005-06-23 2007-01-04 Applera Corporation Thermal-cycling pipette tip
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
JP4473189B2 (en) * 2005-07-22 2010-06-02 株式会社椿本チエイン Drug storage system for drug discovery
US20070026444A1 (en) * 2005-07-27 2007-02-01 Allan Heff Thermal cycling in polymerase chain reactions by thermodynamic methods
GB2428794A (en) * 2005-08-02 2007-02-07 Advanced Biotech Ltd Two part microwell plate and method of fabricating same
GB0517005D0 (en) 2005-08-19 2005-09-28 Enigma Diagnostics Ltd Analytical method and kit
KR101515821B1 (en) 2005-09-01 2015-04-30 오스다이어그나스틱스 피티와이 엘티디. Methods for the amplification, quantitation and identification of nucleic acids
US7630849B2 (en) * 2005-09-01 2009-12-08 Applied Biosystems, Llc Method of automated calibration and diagnosis of laboratory instruments
WO2007028860A1 (en) * 2005-09-06 2007-03-15 Finnzymes Instruments Oy Thermal cycler with optimized sample holder geometry
JP4086065B2 (en) * 2005-10-03 2008-05-14 株式会社日立製作所 Electrophoresis apparatus using capillary array and sample plate assembly used therefor
US11834720B2 (en) 2005-10-11 2023-12-05 Geneohm Sciences, Inc. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ types xi to xx
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
JP4751720B2 (en) * 2005-12-28 2011-08-17 株式会社島津製作所 Genetic analyzer
JP4751719B2 (en) * 2005-12-28 2011-08-17 株式会社島津製作所 Genetic analyzer
JP4751718B2 (en) * 2005-12-28 2011-08-17 株式会社島津製作所 Genetic analyzer
WO2007081387A1 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices, methods of use, and kits for performing diagnostics
CA2637600A1 (en) 2006-01-17 2007-07-26 Health Research, Inc. Heteroduplex tracking assay
US20070175897A1 (en) 2006-01-24 2007-08-02 Labcyte Inc. Multimember closures whose members change relative position
US7794666B2 (en) * 2006-02-07 2010-09-14 Beckman Coulter, Inc. Method and apparatus for controlling reaction temperature in bio-chemical instruments
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
DK2001990T3 (en) 2006-03-24 2016-10-03 Handylab Inc Integrated microfluidic sample processing system and method for its use
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
BRPI0709282B8 (en) 2006-03-29 2021-05-25 Merial Ltd streptococcal vaccine
DK2489943T3 (en) 2006-04-18 2018-10-22 Oy Halton Group Ltd Modular weight for large kitchens
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US9074242B2 (en) 2010-02-12 2015-07-07 Raindance Technologies, Inc. Digital analyte analysis
US20080003142A1 (en) 2006-05-11 2008-01-03 Link Darren R Microfluidic devices
US8232091B2 (en) 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
EP2027251A4 (en) * 2006-05-17 2010-05-05 California Inst Of Techn Thermal cycling system
US8055450B2 (en) * 2006-05-18 2011-11-08 Bio-Rad Laboratories, Inc. Method and apparatus for temperature control
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
WO2007146443A2 (en) * 2006-06-14 2007-12-21 Oldenburg Kevin R Ph D Thermal-cycling devices and methods of using the same
EP2057435A4 (en) * 2006-06-23 2011-04-20 Life Technologies Corp Systems and methods for cooling in biological analysis instruments
US7632464B2 (en) * 2006-06-29 2009-12-15 Bio-Rad Laboratories, Inc. Low-mass sample block with rapid response to temperature change
US20080003149A1 (en) * 2006-06-29 2008-01-03 Bio-Rad Laboratories, Inc. Low mass, rigid sample block
CN1896284B (en) * 2006-06-30 2013-09-11 博奥生物有限公司 Method for identifying allelic gene type
EP1878503A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Temperature sensor element for monitoring heating and cooling
EP1878501A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Instrument for heating and cooling
EP1878502A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Instrument for heating and cooling
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
WO2008014485A2 (en) * 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
EP1898218A3 (en) * 2006-09-05 2009-10-07 FUJIFILM Corporation Cold insulation unit and measurement apparatus
US8962306B2 (en) * 2006-09-08 2015-02-24 Thermo Fisher Scientific Oy Instruments and method relating to thermal cycling
US8592220B2 (en) 2006-10-26 2013-11-26 Intermolecular, Inc. High pressure parallel fixed bed reactor and method
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
EP3118333B1 (en) * 2006-12-13 2019-04-03 Luminex Corporation Systems and methods for multiplex analysis of pcr in real time
AU2007336774A1 (en) 2006-12-22 2008-07-03 3M Innovative Properties Company Thermal transfer methods and structures for microfluidic systems
DE102007002415B4 (en) * 2007-01-17 2011-04-28 Atlas Material Testing Technology Gmbh Device for light or weathering test comprising a sample housing with integrated UV radiation filter
DE102007003754A1 (en) * 2007-01-19 2008-07-24 Eppendorf Ag Temperature control device with calibration device
US20080175757A1 (en) * 2007-01-19 2008-07-24 Andrew Powell Microarray device with elastomeric well structure
EP2109627A4 (en) 2007-01-22 2014-07-23 Wafergen Inc Apparatus for high throughput chemical reactions
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
EP2364777B1 (en) * 2007-02-13 2018-07-25 Eppendorf AG Process for controlling the temperature of samples
EP2359933B1 (en) 2007-02-13 2017-11-08 Eppendorf AG Cover for sample with sample-size independent height adjustment
US20080318280A1 (en) * 2007-02-13 2008-12-25 Eppendorf Ag Cover for an array of reaction vessels for one-step operation modus
US8865457B2 (en) * 2007-03-15 2014-10-21 Siemens Healthcare Diagnostics Inc. Active, micro-well thermal control subsystem
WO2008116184A1 (en) 2007-03-21 2008-09-25 Applera Corporation Adaptive thermal block temperature control method and system
US8153064B2 (en) 2007-03-22 2012-04-10 Doebler Ii Robert W Systems and devices for isothermal biochemical reactions and/or analysis
CA2984820C (en) 2007-04-04 2021-12-07 Ande Corporation Plastic microfluidic separation and detection platforms
EP2132333B1 (en) 2007-04-06 2011-11-23 Becton, Dickinson and Company Compositions and methods for the identification of a carbapenemase gene
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US8323588B2 (en) 2007-05-04 2012-12-04 Quantifoil Instruments Gmbh Sample handling device for and methods of handling a sample
EP2170514B1 (en) * 2007-06-27 2013-05-29 Life Technologies Corporation Multi-material microplate and method
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
GB0715170D0 (en) * 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Reaction vessel
US20110212491A1 (en) * 2007-08-03 2011-09-01 Enigma Diagnostics Limited Reaction vessel
US8460621B2 (en) * 2007-10-15 2013-06-11 Biocision, Llc Temperature transfer stand
JP5200517B2 (en) * 2007-12-04 2013-06-05 凸版印刷株式会社 Reaction vessel
US20090165574A1 (en) * 2007-12-27 2009-07-02 Finnzymes Instruments Oy Instrument and method for nucleic acid amplification
GB2468993A (en) 2007-12-27 2010-09-29 Finnzymes Instr Oy Thermal cycling instrument and methods for carrying out pcr
CA2711854C (en) 2008-01-09 2023-03-21 Keck Graduate Institute System, apparatus and method for material preparation and/or handling
EP2255010B1 (en) * 2008-02-20 2018-05-30 Streck Inc. Thermocycler and sample vessel for rapid amplification of dna
WO2009111475A2 (en) 2008-03-03 2009-09-11 Heatflow Technologies, Inc. Heat flow polymerase chain reaction systems and methods
US20110156090A1 (en) * 2008-03-25 2011-06-30 Lin Charles W C Semiconductor chip assembly with post/base/post heat spreader and asymmetric posts
WO2009124012A1 (en) * 2008-03-31 2009-10-08 Dow Global Technologies Inc. A design for rapidly cloning one or more polypeptide chains into an expression system
EP2108451A1 (en) 2008-04-11 2009-10-14 Eppendorf AG Device for causing reactions in samples
JP2009254260A (en) * 2008-04-15 2009-11-05 Sony Corp Reaction treatment device
US20090275116A1 (en) * 2008-04-30 2009-11-05 Venugopal Subramanyam Metallic PCR frames
US8999703B2 (en) * 2008-05-05 2015-04-07 Daniel P. Welch Cell container
WO2010009199A2 (en) 2008-07-17 2010-01-21 Douglas Machine Inc. Microplate and methods for making the same
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US8633015B2 (en) * 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
WO2011120024A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet generation for droplet-based assays
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
DE202008014837U1 (en) 2008-11-07 2010-03-11 Aj Roboscreen Gmbh Device for receiving connected reaction spaces
EP2356423A1 (en) 2008-11-12 2011-08-17 Ventana Medical Systems, Inc. Methods and apparatuses for heating slides carrying specimens
KR101143975B1 (en) * 2008-12-16 2012-05-09 엘지전자 주식회사 Refrigerator
IT1397110B1 (en) * 2008-12-29 2012-12-28 St Microelectronics Rousset SELF-SEALING MICROREACTOR AND METHOD TO CARRY OUT A REACTION
AU2010208085B2 (en) * 2009-01-30 2014-02-06 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
EP2398921B1 (en) 2009-02-19 2015-08-05 Becton Dickinson Infusion Therapy Systems Inc. Methods for the detection and identification of extended spectrum beta lactamases
US20100279299A1 (en) * 2009-04-03 2010-11-04 Helixis, Inc. Devices and Methods for Heating Biological Samples
WO2010129704A2 (en) * 2009-05-05 2010-11-11 Pressure Biosciences Inc. Microtube and related methods therefor
US20100288059A1 (en) * 2009-05-14 2010-11-18 Streck, Inc. Specimen container, system, and method
US9166139B2 (en) * 2009-05-14 2015-10-20 The Neothermal Energy Company Method for thermally cycling an object including a polarizable material
GB0910330D0 (en) * 2009-06-16 2009-07-29 Univ Leiden A biological microfluidics chip and related methods
AU2010266034B2 (en) * 2009-06-26 2016-12-15 Claremont Biosolutions Llc Capture and elution of bio-analytes via beads that are used to disrupt specimens
GB2511693A (en) * 2009-08-08 2014-09-10 Bibby Scient Ltd An apparatus for treating a test sample
GB2512764B (en) * 2009-08-08 2014-12-24 Bibby Scient Ltd An apparatus for treating a test sample
CN102471746B (en) * 2009-08-20 2013-07-10 宝生物工程有限公司 Temperature cycling device
IN2012DN02105A (en) * 2009-09-01 2015-08-21 Life Technologies Corp
JP6155418B2 (en) 2009-09-02 2017-07-05 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド System for mixing fluids by combining multiple emulsions
CN201837588U (en) 2009-09-09 2011-05-18 海利克斯公司 Optical system for multiple reactions
JP5426993B2 (en) * 2009-10-30 2014-02-26 アークレイ株式会社 Temperature control apparatus and temperature control method
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
US20110127254A1 (en) * 2009-11-30 2011-06-02 Cypress Technology Llc Electric Heating Systems and Associated Methods
JP5680950B2 (en) * 2009-12-10 2015-03-04 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Multiwell plate and lid
EP2338594A1 (en) * 2009-12-23 2011-06-29 PEQLAB Biotechnologie GmbH Thermal plate
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US20130029343A1 (en) * 2010-02-22 2013-01-31 4Titude Ltd. Multiwell strips
JP6154137B2 (en) 2010-02-23 2017-06-28 ルミネックス コーポレーション Apparatus and method for integrated sample preparation, reaction, and detection
US8399198B2 (en) 2010-03-02 2013-03-19 Bio-Rad Laboratories, Inc. Assays with droplets transformed into capsules
EP2556170A4 (en) 2010-03-25 2014-01-01 Quantalife Inc Droplet transport system for detection
CA2767113A1 (en) 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Detection system for droplet-based assays
EP2556173B1 (en) 2010-04-09 2021-05-26 Life Technologies Corporation Improved thermal uniformity for thermal cycler instrumentation using dynamic control
US8383793B2 (en) 2010-04-15 2013-02-26 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
MX2012012172A (en) 2010-04-20 2013-01-18 Corbett Res Pty Ltd Temperature control method and apparatus.
EP2612123B1 (en) * 2010-08-31 2016-08-10 Canon U.S. Life Sciences, Inc. Compound calibrator for thermal sensors
WO2012031050A1 (en) * 2010-08-31 2012-03-08 Canon U.S. Life Sciences, Inc. Thermal calibration
US9144801B2 (en) 2010-08-31 2015-09-29 Abbott Laboratories Sample tube racks having retention bars
WO2012032519A2 (en) 2010-09-07 2012-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of diagnosing parkinson's disease
WO2012033914A1 (en) * 2010-09-09 2012-03-15 Battelle Memorial Institute Heating a short section of tape or wire to a controlled temperature
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
EP3974831A1 (en) 2010-10-22 2022-03-30 T2 Biosystems, Inc. Methods for detecting the presence of a bacterium in a whole blood sample
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
EP3574990B1 (en) 2010-11-01 2022-04-06 Bio-Rad Laboratories, Inc. System for forming emulsions
JP5722001B2 (en) * 2010-11-10 2015-05-20 株式会社日立ハイテクノロジーズ Genetic testing method and testing device
EP2463382A1 (en) 2010-12-07 2012-06-13 Enterologics, Inc. Method for identifying E. Coli M-17
US10159982B2 (en) 2010-12-08 2018-12-25 Applied Biosystems B.V. Control systems and methods for biological applications
CN103476498B (en) 2010-12-17 2016-09-28 Bjsip有限公司 Method and system for fast PCR heating
US20130316358A1 (en) 2011-01-31 2013-11-28 Yeda Research And Development Co. Ltd. Methods of diagnosing disease using overlap extension pcr
EP2481812A1 (en) 2011-01-31 2012-08-01 Westfälische Wilhelms-Universität Münster Molecular sexing of avian subjects
EP3859011A1 (en) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Methods for forming mixed droplets
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
BR112013022889B8 (en) 2011-03-08 2022-12-20 Univ Laval CENTRIPETAL FLUIDIC DEVICE FOR TESTING COMPONENTS OF A BIOLOGICAL MATERIAL IN A FLUID, TEST APPARATUS AND TESTING METHOD USING SUCH CENTRIPETAL FLUIDIC DEVICE
AU2012231098B2 (en) 2011-03-18 2016-09-29 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
US20140157443A1 (en) 2011-04-14 2014-06-05 St. Jude Children's Research Hospital Methods and compositions for detecting and modulating a novel mtor complex
CA2833262C (en) 2011-04-15 2020-08-18 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
EP2699352A1 (en) 2011-04-21 2014-02-26 Streck Inc. Improved sample tube having particular utility for nucleic acid amplification
CA2834291A1 (en) 2011-04-25 2012-11-01 Biorad Laboratories, Inc. Methods and compositions for nucleic acid analysis
US8968684B2 (en) 2011-04-28 2015-03-03 Bin Lian Microplates, reaction modules and detection systems
AU2012250619B2 (en) 2011-05-04 2015-11-26 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
AU2012255144B2 (en) 2011-05-18 2015-01-29 Diasorin Italia S.P.A. Systems and methods for volumetric metering on a sample processing device
JP2014517291A (en) 2011-05-18 2014-07-17 スリーエム イノベイティブ プロパティズ カンパニー System and method for valve operation of a sample processing apparatus
US9168523B2 (en) 2011-05-18 2015-10-27 3M Innovative Properties Company Systems and methods for detecting the presence of a selected volume of material in a sample processing device
CA2835654A1 (en) 2011-06-01 2012-12-06 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
WO2012167142A2 (en) 2011-06-02 2012-12-06 Raindance Technolgies, Inc. Enzyme quantification
JP2013009585A (en) * 2011-06-23 2013-01-10 Sensata Technologies Massachusetts Inc Assembly of electric motor starter components
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013019751A1 (en) 2011-07-29 2013-02-07 Bio-Rad Laboratories, Inc., Library characterization by digital assay
CN104040238B (en) 2011-11-04 2017-06-27 汉迪拉布公司 Polynucleotides sample preparation apparatus
EP2795757A4 (en) * 2011-12-19 2015-09-16 Husky Injection Molding System for disconnecting electrical power upon regulation failure
ITBO20110766A1 (en) * 2011-12-28 2013-06-29 Silicon Biosystems Spa DEVICES, EQUIPMENT, KITS AND METHOD FOR THE TREATMENT OF A BIOLOGICAL SAMPLE
DK2809810T3 (en) 2012-01-06 2020-02-03 Viomics Inc METHOD AND METHOD OF DETECTING IN PERFERRAL BLOOD OF LUNG CANCER MODIFIED RNAs
US9040000B2 (en) 2012-01-26 2015-05-26 Heatflow Technologies Inc. Sample container with sensor receptacle and methods of use
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
EP2834375B1 (en) 2012-04-06 2021-05-05 Geneohm Sciences Canada, Inc. Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) of mrej type xxi
WO2013155531A2 (en) 2012-04-13 2013-10-17 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US9562271B2 (en) 2012-04-20 2017-02-07 T2 Biosystems, Inc. Compositions and methods for detection of Candida species
US9579657B2 (en) 2012-05-24 2017-02-28 Bjs Ip Ltd Clamp for fast PCR heating
EP2875131B1 (en) 2012-07-18 2018-03-14 Siemens Healthcare Diagnostics Inc. A method of normalizing biological samples
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
US9932632B2 (en) 2012-08-10 2018-04-03 Streck, Inc. Real-time optical system for polymerase chain reaction
US20140112829A1 (en) * 2012-10-22 2014-04-24 Qiagen Gaithersburg, Inc. Tube strip handling and heating apparatus
USD735881S1 (en) 2012-10-22 2015-08-04 Qiagen Gaithersburg, Inc. Tube strip holder for automated processing systems
US9180461B2 (en) 2012-10-22 2015-11-10 Qiagen Gaithersburg, Inc. Condensation-reducing incubation cover
US9512468B2 (en) * 2012-11-06 2016-12-06 Industrial Technology Research Institute Detection method uses magnetic and detectable nanoparticles with oligonucleotides attached thereto
JP6078346B2 (en) * 2013-01-07 2017-02-08 株式会社日立ハイテクノロジーズ Nucleic acid amplification apparatus, temperature control method, and temperature control apparatus
WO2014108850A2 (en) 2013-01-09 2014-07-17 Yeda Research And Development Co. Ltd. High throughput transcriptome analysis
JP6180745B2 (en) * 2013-01-30 2017-08-16 株式会社日立ハイテクノロジーズ Nucleic acid analyzer
JP2014147296A (en) * 2013-01-31 2014-08-21 Hitachi High-Technologies Corp Nucleic acid inspection device
US9045795B2 (en) * 2013-03-13 2015-06-02 Life Technologies Corporation Methods to control dissolved gas
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
US9039993B2 (en) 2013-03-14 2015-05-26 Formulatrix, Inc. Microfluidic device
AU2013202778A1 (en) * 2013-03-14 2014-10-02 Gen-Probe Incorporated Systems, methods, and apparatuses for performing automated reagent-based assays
US9163277B2 (en) 2013-03-14 2015-10-20 Formulatrix, Inc. Microfluidic device
US9108772B2 (en) 2013-03-15 2015-08-18 Scientific Specialties, Inc. Container latching systems for one-handed operation
CN107233945B (en) 2013-03-19 2019-10-11 生命科技股份有限公司 Thermal cycler capping
KR101492230B1 (en) * 2013-05-14 2015-02-13 (주)마이크로디지탈 Polymerase chain reaction system
US10415084B2 (en) 2013-06-27 2019-09-17 Quark Biosciences Taiwan, Inc. Multiplex slide plate device and operation method thereof
US9724692B2 (en) * 2013-06-27 2017-08-08 Quark Biosciences, Inc. Multiplex slide plate
EP3495803A1 (en) 2013-06-28 2019-06-12 Streck, Inc. Devices for real-time polymerase chain reaction
CN204625602U (en) 2013-09-16 2015-09-09 生命科技股份有限公司 Hot frame assembly and heat circulating system
SE537326C2 (en) * 2013-09-30 2015-04-07 Symcel Sverige AB Provvial
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US10036058B2 (en) 2013-10-07 2018-07-31 Agdia Inc. Portable testing device for analyzing biological samples
GB201319759D0 (en) * 2013-11-08 2013-12-25 Thomsen Lars Device and method for heating a fluid chamber
JP6128234B2 (en) * 2013-12-02 2017-05-17 株式会社島津製作所 Analytical apparatus and autosampler used therefor
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
CN117054211A (en) 2013-12-13 2023-11-14 文塔纳医疗系统公司 Automated histological processing of biological samples and related techniques
JP5820459B2 (en) * 2013-12-18 2015-11-24 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． Thermocycle device
US10471431B2 (en) 2014-02-18 2019-11-12 Life Technologies Corporation Apparatuses, systems and methods for providing scalable thermal cyclers and isolating thermoelectric devices
US20170065971A1 (en) 2014-03-04 2017-03-09 Streck, Inc. Improved sample tube with transparent tip having particular utility for nucleic acid amplification
US20150257183A1 (en) * 2014-03-06 2015-09-10 Paz Pentelka Apparatus, system and method of identifying a wireless docking station
WO2015148702A1 (en) * 2014-03-26 2015-10-01 Sigma Labs, Inc. Optical manufacturing process sensing and status indication system
WO2015159293A2 (en) 2014-04-14 2015-10-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A method and kit for determining the tissue or cell origin of dna
US9279797B2 (en) * 2014-06-12 2016-03-08 Axion Biosystems, Inc. Multiwell microelectrode array with optical stimulation
JP6452965B2 (en) * 2014-06-13 2019-01-16 株式会社日立ハイテクノロジーズ Nucleic acid amplification equipment
WO2016004022A2 (en) * 2014-06-30 2016-01-07 Gnubio, Inc. Floating thermal contact enabled pcr
WO2016003543A1 (en) * 2014-07-02 2016-01-07 Taunk Dale Singh Ergonomic numbered connector to hold tubes with improved cap
GB201416422D0 (en) * 2014-09-17 2014-10-29 Illumina Cambridge Ltd Flexible tape-based chemistry apparatus
DE102014018308A1 (en) * 2014-12-10 2016-06-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Temperature control body for a multiwell plate and method and apparatus for freezing and / or thawing biological samples
EP3254079B1 (en) * 2015-02-06 2021-05-19 Life Technologies Corporation Methods and systems for biological instrument calibration
WO2016134342A1 (en) 2015-02-20 2016-08-25 Wafergen, Inc. Method for rapid accurate dispensing, visualization and analysis of single cells
CN104630057B (en) * 2015-03-05 2016-08-17 东南大学 A kind of full-automatic heat circulating instrument heat lid
EP3069745B1 (en) * 2015-03-16 2023-12-27 The Surgical Company International B.V. Fluid warming system with biased layers
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US10207272B2 (en) 2015-04-19 2019-02-19 VitroSolutions, LLC Method and device for placement of microscopic sample into the tube
DE102015108173A1 (en) 2015-05-22 2016-11-24 Degudent Gmbh Process for increasing the strength of shaped bodies consisting of lithium silicate glass-ceramic
US10763142B2 (en) 2015-06-22 2020-09-01 Lam Research Corporation System and method for determining field non-uniformities of a wafer processing chamber using a wafer processing parameter
US10386821B2 (en) 2015-06-22 2019-08-20 Lam Research Corporation Systems and methods for calibrating scalar field contribution values for a limited number of sensors including a temperature value of an electrostatic chuck and estimating temperature distribution profiles based on calibrated values
US9779974B2 (en) 2015-06-22 2017-10-03 Lam Research Corporation System and method for reducing temperature transition in an electrostatic chuck
US10381248B2 (en) * 2015-06-22 2019-08-13 Lam Research Corporation Auto-correction of electrostatic chuck temperature non-uniformity
ES2843532T3 (en) * 2015-07-23 2021-07-19 Cepheid Thermal control device and methods of use
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
US10059061B2 (en) * 2015-10-07 2018-08-28 The Boeing Company Composite manufacturing with a multi-dimensional array of independently-controllable thermal zones
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
CN108350485A (en) 2015-10-30 2018-07-31 精密科学发展有限责任公司 The multiplex amplification detection assay of plasma dna and separation and detection
RU2640186C2 (en) * 2015-11-19 2017-12-26 Федеральное государственное бюджетное учреждение науки Институт аналитического приборостроения Российской академии наук (ИАП РАН) Device for real time simultaneous control of plurality of nucleic acid amplifications
JP2017108710A (en) * 2015-12-18 2017-06-22 ウシオ電機株式会社 Sample heating apparatus
JP2019512208A (en) 2016-01-21 2019-05-16 ティー２ バイオシステムズ，インコーポレーテッド NMR method and system for detecting bacteria quickly
EP3907292A1 (en) 2016-03-03 2021-11-10 Memed Diagnostics Ltd. Analyzing rna for diagnosing infection type
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
SG10201700260XA (en) * 2016-06-10 2018-01-30 Star Array Pte Ltd Rapid thermal cycling for sample analyses and processing
TWI713536B (en) * 2016-06-15 2020-12-21 諾貝爾生物有限公司 Capping system for biological thermal reaction and method of using the same
JP2018009968A (en) * 2016-06-30 2018-01-18 株式会社Ｓｃｒｅｅｎホールディングス Well plate and usage of the well plate
WO2018017892A1 (en) 2016-07-21 2018-01-25 Takara Bio Usa, Inc. Multi-z imaging and dispensing with multi-well devices
RU2666209C2 (en) * 2016-09-22 2018-09-06 Федеральное государственное бюджетное учреждение науки Институт аналитического приборостроения Российской академии наук (ИАП РАН) Apparatus for real-time simultaneous monitoring of multiple nucleic acid amplifications
CN107051611B (en) * 2016-12-27 2019-02-22 苏州欣祥本机械科技有限公司 A kind of medical tubes storage box
US10722893B2 (en) * 2017-01-13 2020-07-28 Shimadzu Corporation Mounting and heating mechanism of sample collection containers
WO2018150648A1 (en) * 2017-02-20 2018-08-23 株式会社日立製作所 Temperature regulating device and nucleic-acid amplification device
US11761032B2 (en) * 2017-03-11 2023-09-19 Yan Wang Methods and devices for performing real time digital PCR
US20200180991A1 (en) * 2017-04-28 2020-06-11 Corning Incorporated Glass structure, glass structure forming system, and method of making glass structure
JP6831539B2 (en) 2017-05-22 2021-02-17 栄研化学株式会社 Reagent cartridge
KR20220104847A (en) 2017-06-30 2022-07-26 인스크립타 인코포레이티드 Automated cell processing methods, modules, instruments, and systems
US10738327B2 (en) 2017-08-28 2020-08-11 Inscripta, Inc. Electroporation cuvettes for automation
WO2019068022A1 (en) 2017-09-30 2019-04-04 Inscripta, Inc. Flow through electroporation instrumentation
US11154864B2 (en) 2018-01-17 2021-10-26 Qiagen Sciences, Llc Microfluidic device with vented microchambers
CN110157590A (en) * 2018-02-13 2019-08-23 光鼎生物科技（江苏）有限公司 Thermal cycler
US10443031B1 (en) 2018-03-29 2019-10-15 Inscripta, Inc. Methods for controlling the growth of prokaryotic and eukaryotic cells
US10376889B1 (en) 2018-04-13 2019-08-13 Inscripta, Inc. Automated cell processing instruments comprising reagent cartridges
US10858761B2 (en) 2018-04-24 2020-12-08 Inscripta, Inc. Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
CN114854720A (en) 2018-06-30 2022-08-05 因思科瑞普特公司 Apparatus, modules and methods for improved detection of editing sequences in living cells
JP7067620B2 (en) * 2018-07-03 2022-05-16 株式会社島津製作所 Sample dispensing aid and sample dispensing method
US11142740B2 (en) 2018-08-14 2021-10-12 Inscripta, Inc. Detection of nuclease edited sequences in automated modules and instruments
US10752874B2 (en) 2018-08-14 2020-08-25 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
US10532324B1 (en) 2018-08-14 2020-01-14 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
WO2020036926A1 (en) 2018-08-17 2020-02-20 Cellecta, Inc. Multiplex preparation of barcoded gene specific dna fragments
CN109097455B (en) * 2018-09-03 2022-11-11 中国科学院长春光学精密机械与物理研究所 Polymerase chain reaction system
EP3853373A4 (en) 2018-09-17 2022-06-22 The University of North Carolina at Chapel Hill Method for quantifying dna fragments in a sample by size
EP3626344A1 (en) * 2018-09-21 2020-03-25 Eppendorf AG Thermocycler and method for controlling a thermocycler
US11298701B2 (en) 2018-11-26 2022-04-12 King Instrumentation Technologies Microtiter plate mixing control system
KR102009505B1 (en) * 2019-01-17 2019-08-12 주식회사 엘지화학 Module for polymerase chain reaction of sample
CN109663621A (en) * 2019-01-17 2019-04-23 京东方科技集团股份有限公司 A kind of preparation method, micro-nano-fluidic control chip and the device of micro-nano structure substrate
CN109735437B (en) * 2019-01-28 2022-04-19 长春长光辰英生物科学仪器有限公司 Vessel and method for collecting and processing cells after ejection sorting of cells
CN109806923A (en) * 2019-01-29 2019-05-28 莫纳（苏州）生物科技有限公司 A kind of PCR pedestal and PCR instrument
US10862502B2 (en) 2019-03-04 2020-12-08 Analog Devices International Unlimited Company ADC output drift correction techniques
JP2022525322A (en) 2019-03-14 2022-05-12 インシリクサ， インコーポレイテッド Methods and systems for time-gate fluorescence-based detection
CN110170348B (en) * 2019-05-26 2020-08-14 徐子昕 A low-pressure cooker for heating microcentrifuge tube
EP3969877A1 (en) 2019-06-03 2022-03-23 Entech Instruments Inc. Improved recovery of organic compounds in liquid samples using full evaporative vacuum extraction, thermal desorption, and gcms analysis
US10907125B2 (en) 2019-06-20 2021-02-02 Inscripta, Inc. Flow through electroporation modules and instrumentation
EP3986909A4 (en) 2019-06-21 2023-08-02 Inscripta, Inc. Genome-wide rationally-designed mutations leading to enhanced lysine production in e. coli
US10927385B2 (en) 2019-06-25 2021-02-23 Inscripta, Inc. Increased nucleic-acid guided cell editing in yeast
CN110501511B (en) * 2019-08-13 2023-08-08 迈克医疗电子有限公司 Online reagent adjusting method, device and analysis and detection system
EP3901286A1 (en) 2020-04-24 2021-10-27 Mirnax Biosens, S.L. Bivalent reverse primer
WO2021089643A1 (en) 2019-11-04 2021-05-14 Mirnax Biosens, S.L. Bivalent reverse primer
BR112022010014A2 (en) 2019-11-26 2022-08-16 Ovo Incubators Pty Ltd INCUBATOR
CN111154643A (en) * 2020-01-10 2020-05-15 福建红帽子环境科技有限公司 Water-based dismutase generating device
US10689669B1 (en) 2020-01-11 2020-06-23 Inscripta, Inc. Automated multi-module cell processing methods, instruments, and systems
WO2021154706A1 (en) 2020-01-27 2021-08-05 Inscripta, Inc. Electroporation modules and instrumentation
WO2021188540A2 (en) 2020-03-16 2021-09-23 The University Of North Carolina At Chapel Hill Compositions and methods for the selective detection of tumor-derived viral dna
JP7460752B2 (en) * 2020-03-17 2024-04-02 株式会社日立ハイテク automatic analyzer
US11597255B2 (en) * 2020-03-25 2023-03-07 Pony Al Inc. Systems and methods for cooling vehicle components
US20210332388A1 (en) 2020-04-24 2021-10-28 Inscripta, Inc. Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
US11787841B2 (en) 2020-05-19 2023-10-17 Inscripta, Inc. Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
CN111830933B (en) * 2020-07-16 2022-03-29 广东亨通光电科技有限公司 Heating element detection system, method and device and storage medium
CN114384945B (en) * 2020-10-21 2023-06-27 Oppo广东移动通信有限公司 Processor temperature control method and device, storage medium and electronic equipment
IL278473A (en) 2020-11-03 2022-06-01 Yeda Res & Dev Methods of prognosing, determining treatment course and treating multiple myeloma
JP7327360B2 (en) 2020-11-19 2023-08-16 横河電機株式会社 Heat treatment system, nucleic acid extraction system, nucleic acid analysis system
EP4249580A1 (en) 2020-11-19 2023-09-27 Yokogawa Electric Corporation Treatment apparatus, nucleic acid extraction system, and nucleic acid analysis system
CN112698675A (en) * 2020-12-24 2021-04-23 南通浩洋节能科技有限公司 Control device of constant temperature equipment
RU2760495C1 (en) * 2021-02-25 2021-11-25 Общество с ограниченной ответственностью «НПО ТЕХОСНАСТКА» Tubes in strip
CN113219190B (en) * 2021-05-17 2022-05-24 青岛市三凯医学科技有限公司 Full-automatic layered heating and cooling detection equipment and method
CA3221196A1 (en) 2021-05-21 2022-11-24 Ovo Incubators (Pty) Ltd Incubator tray and a method of incubating
RU210037U1 (en) * 2021-09-22 2022-03-25 Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" TEMPERATURE MAINTENANCE DEVICE FOR SYNCHRONOUS CULTIVATION OF MICROORGANISMS
CN113753381B (en) * 2021-10-18 2022-11-15 镇江金太医学检验实验室有限公司 Novel coronavirus multiplex PCR (polymerase chain reaction) rapid detection kit
CN114015546B (en) * 2021-10-23 2022-10-28 美东汇成生命科技(昆山)有限公司 PCR single tube with strong sealing performance
CN114115380B (en) * 2021-11-24 2022-07-22 广东华中科技大学工业技术研究院 Temperature control method and system for 3D glass hot bending die
GB2613338A (en) * 2021-11-24 2023-06-07 Genomtec Sa Thermal interface arrangement
CN114260030B (en) * 2021-12-27 2023-11-03 威海沃驰智能技术有限公司 Test tube sample preservation cabinet for biotechnology
TW202338077A (en) * 2022-03-22 2023-10-01 列特博生技股份有限公司 Multi-function polymerase chain reaction device and controlling method thereof
EP4306941A1 (en) * 2022-07-11 2024-01-17 Furuno Electric Co., Ltd. Apparatus and method for checking stirring quality of a chemical analyzer
CN115074236B (en) * 2022-07-21 2022-10-25 鲲鹏基因（北京）科技有限责任公司 Temperature control device for PCR instrument, amplification equipment and PCR instrument
WO2024038457A1 (en) 2022-08-18 2024-02-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A method for determining the tissue or cell of origin of dna
CN115649527B (en) * 2022-11-14 2023-03-21 长沙市第一医院 Disposable nursing pad automatic packaging machine
CN117491672B (en) * 2023-12-29 2024-03-15 佳木斯市中心医院 Pediatric urine collection and detection equipment

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US34133A (en) * 1862-01-14 Improvement in grain thrashers and separators
FR413708A (en) * 1909-03-22 1910-08-17 Adrian Baumann Ball
DK105348C (en) * 1964-07-20 1966-09-19 Cai Aage Casper Moeller Control coupling for controlling temperature variations in a medium.
US3311303A (en) * 1965-09-28 1967-03-28 Gen Electric Programmer
US3483997A (en) * 1967-07-03 1969-12-16 Harry W Ritter Test tube rack and test tube capping devices
GB1247520A (en) * 1967-10-23 1971-09-22 Ole Rues Container for laboratory use
US3856471A (en) * 1968-08-05 1974-12-24 Nasa Amino acid analysis
US3799426A (en) * 1972-04-12 1974-03-26 D Lacy Container
US3847200A (en) * 1972-05-01 1974-11-12 Brinkmann Instr Inc Apparatus for concentrating laboratory specimens by evaporation
US3912913A (en) * 1973-04-09 1975-10-14 Courtaulds Eng Ltd Process control method and apparatus
GB1474524A (en) * 1973-07-06 1977-05-25
US3983363A (en) * 1975-02-03 1976-09-28 Alter R R Electrically heated semen warming and storage unit
FR2330976A1 (en) * 1975-11-05 1977-06-03 Air Ind Electric heat pump - consists of heat exchange elements having central region with several arms at right angles
DE2603683A1 (en) * 1976-01-31 1977-08-11 Loo Hans Michael Van De Dr Rer Covered stand for small reaction vessels - with cover fixed against stoppers of vessels to maintain them in position
USRE34133E (en) * 1976-07-23 1992-11-24 Dynatech Holdings, Ltd. Microtest plates
US4154795A (en) * 1976-07-23 1979-05-15 Dynatech Holdings Limited Microtest plates
US4094641A (en) * 1977-02-25 1978-06-13 Waters Associates, Inc. Low loss sample bottle assembly
US4206872A (en) * 1977-03-17 1980-06-10 Levine Michael R Electronic thermostat
FR2413708A1 (en) * 1977-12-30 1979-07-27 Poudres & Explosifs Ste Nale Temp. regulator associated with heat exchanger - obtains error signal for control by comparing measured temp. with setting temp.
JPS55136958A (en) * 1979-04-14 1980-10-25 Olympus Optical Co Ltd Automatic analyzer
US4244920A (en) * 1979-12-10 1981-01-13 Plastronics, Inc. Specimen collection assembly
US4312835A (en) * 1980-04-21 1982-01-26 American Cyanamid Company Thermal control means for liquid chromatograph samples
US4310488A (en) * 1980-05-19 1982-01-12 Hoffmann-La Roche Inc. Sample or reagent container for analyzers
DE3026267C2 (en) * 1980-07-11 1983-10-27 Hewlett-Packard GmbH, 7030 Böblingen Thermostating device for liquid chromatographs
US4335620A (en) * 1980-07-16 1982-06-22 The Upjohn Company Temperature controlled sample carrier
CH647086A5 (en) * 1980-09-16 1984-12-28 Mettler Instrumente Ag METHOD OF CONTROLLING THE TEMPERATURE OF A FURNACE FOR THERMOANALYTIC EXPERIMENTS.
JPS5754157A (en) * 1980-09-19 1982-03-31 Nippon Kayaku Co Ltd L-argininal derivative and its preparation
JPS5798013A (en) * 1980-12-12 1982-06-18 Olympus Optical Co Ltd Controlling system of cooler in chemical analyzing apparatus
US4348207A (en) * 1981-01-29 1982-09-07 Cooper Laboratories, Inc. Method and means for determination of pregnancy
US4362699A (en) * 1981-03-10 1982-12-07 Bio Research, Inc. Apparatus for high pressure peptide synthesis
JPS57201645A (en) * 1981-06-08 1982-12-10 Kyokuto Shibosan Kk Method and device for manufacturing corrugated cardboard with corrugated composite core
JPS5841358A (en) * 1981-09-04 1983-03-10 Hitachi Ltd Automatic analyzer
US4518700A (en) * 1981-12-04 1985-05-21 Beckman Instruments, Inc. Method and apparatus for regulating the temperature of an analytical instrument reactor
US4534941A (en) * 1981-12-04 1985-08-13 Beckman Instruments, Inc. Analytical instrument thermoelectric temperature regulator
US4663290A (en) * 1982-01-21 1987-05-05 Molecular Genetics, Inc. Production of reverse transcriptase
DE3238535A1 (en) * 1982-10-18 1984-04-19 Planer Products Ltd., Sunbury-on-Thames, Middlesex Process and apparatus for controlled cooling of a product
US4478094A (en) * 1983-01-21 1984-10-23 Cetus Corporation Liquid sample handling system
CH654210A5 (en) * 1983-05-20 1986-02-14 Hasunor Ag PROCEDURE TO GET PREPARED metabolically INCOME OBTAINED FROM YEAST OF ANY KIND.
EP0134622A3 (en) * 1983-05-25 1986-10-08 Georgetown University Apparatus and method for separating polynucleotides and detecting specific polynucleotide sequences
US4599314A (en) * 1983-06-14 1986-07-08 Hsc Research Development Corporation Multiple vessel specimen tray with lid for releasably adhering vessel covers
FI833076A0 (en) * 1983-08-30 1983-08-30 Labsystems Oy ANORDNING FOER MAETNING AV UPPVAERMBARA VAETSKEPROV
US4598049A (en) * 1983-08-31 1986-07-01 Systec Inc. General purpose gene synthesizer
US4554839A (en) * 1983-10-14 1985-11-26 Cetus Corporation Multiple trough vessel for automated liquid handling apparatus
DE3402276C1 (en) * 1984-01-24 1985-02-21 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Plastic reaction vessel for small amounts of liquid
IL71131A (en) * 1984-03-02 1988-09-30 Product Advanced Ltd Method and apparatus for heating and/or cooling objects simultaneously at different preselected temperatures
US4554436A (en) * 1984-03-15 1985-11-19 Bodenseewerk Perkin-Elmer & Co., Gmbh Electric heater for a rotating sample vessel container in a sampling device for gas chromatography
DE3412157A1 (en) * 1984-03-31 1985-10-03 Kernforschungsanlage Jülich GmbH, 5170 Jülich METHOD AND THERMOSTAT FOR SETTING A CONSTANT TEMPERATURE FOR A FLUID WITH A LOW MASS CURRENT
JPS60241884A (en) * 1984-05-15 1985-11-30 Tokyo Daigaku Automation cycling reaction apparatus and automatic analyzer using same
US4504733A (en) * 1984-05-15 1985-03-12 Sybron Corporation Dry bath temperature control
US4711851A (en) * 1984-05-21 1987-12-08 State University Of New York Test apparatus for determining a metabolic characteristic of microorganisms
US4683194A (en) * 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
JPS6130597A (en) * 1984-07-20 1986-02-12 Nippon Zeon Co Ltd Device for synthesizing polynucleotide
CH664094A5 (en) * 1984-08-30 1988-02-15 Treff Ag Clip-on lid covers arrayed containers - projecting from apertured carrier plate
US4685081A (en) * 1984-12-17 1987-08-04 Allied Corporation Peltier junction used for thermal control of solid state devices
US4708886A (en) * 1985-02-27 1987-11-24 Fisher Scientific Company Analysis system
US5008182A (en) * 1986-01-10 1991-04-16 Cetus Corporation Detection of AIDS associated virus by polymerase chain reaction
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
ES8706823A1 (en) * 1985-03-28 1987-06-16 Cetus Corp Process for amplifying, detecting, and/or cloning nucleic acid sequences.
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5038852A (en) * 1986-02-25 1991-08-13 Cetus Corporation Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US4693834A (en) * 1986-05-05 1987-09-15 Murex Corporation Transverse flow diagnostic kit
US4863849A (en) * 1985-07-18 1989-09-05 New York Medical College Automatable process for sequencing nucleotide
DE3682502D1 (en) * 1985-08-21 1991-12-19 Biotope Inc METHOD AND DEVICES FOR SEPARATING, MIXING AND DETERMINING COMPONENTS IN SPECIFIC BINDING TESTS.
US4858155A (en) * 1985-12-24 1989-08-15 Beckman Instruments, Inc. Reaction temperature control system
US4755356A (en) * 1986-01-23 1988-07-05 Robbins Scientific Corporation Locking microcentrifuge tube
US4800159A (en) * 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
CA1339653C (en) * 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
GB2193725A (en) * 1986-03-17 1988-02-17 Flow Lab Incubator
US4933146A (en) * 1986-07-11 1990-06-12 Beckman Instruments, Inc. Temperature control apparatus for automated clinical analyzer
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
CA1338457C (en) 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
US4742225A (en) * 1986-10-16 1988-05-03 Eastman Kodak Company Elliptical cylinder light collector for photosimulable phosphor imaging apparatus
US5084246A (en) * 1986-10-28 1992-01-28 Costar Corporation Multi-well test plate
BE1000415A7 (en) * 1987-03-18 1988-11-22 Bell Telephone Mfg Asynchronous based on time division operating communication.
EP0311440B1 (en) * 1987-10-09 1992-06-24 Seiko Instruments Inc. Apparatus for carrying out a liquid reaction
US4988618A (en) * 1987-11-16 1991-01-29 Gene-Trak Systems Magnetic separation device and methods for use in heterogeneous assays
US4902624A (en) * 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
FI79342C (en) * 1987-12-23 1989-12-11 Orion Yhtymae Oy APPARATUS, DEL AV EN APPARAT OCH FOERFARANDE FOER MAONGFALDIGANDE AV NUKLEINSYROR.
DE3843610A1 (en) * 1988-01-13 1989-07-27 Stephan Dr Diekmann DISCONNECTING OR REACTION PILLAR UNIT
GB8807297D0 (en) * 1988-03-26 1988-04-27 Dean P D G Intelligent heating block
US4953741A (en) * 1988-05-09 1990-09-04 Multi-Technology Inc. Medical fail safe releasible locks and/or seals for capped disposable centrifuge containers, cryogenic vials and the like
EP0342155A3 (en) * 1988-05-13 1990-06-27 Agrogen-Stiftung Laboratory device for optional heating and cooling
GB8814962D0 (en) * 1988-06-23 1988-07-27 Lep Scient Ltd Biochemical reaction machine
DE8808738U1 (en) * 1988-07-07 1988-09-01 Diekmann, Stephan, Dr., 3400 Goettingen, De
US4990129A (en) * 1988-08-16 1991-02-05 Nielsen Steven T Swinging bucket ultracentrifuge rotor, sample tube and adapter
US5075216A (en) * 1988-09-23 1991-12-24 Cetus Corporation Methods for dna sequencing with thermus aquaticus dna polymerase
US4865986A (en) * 1988-10-06 1989-09-12 Coy Corporation Temperature control apparatus
DE3839162A1 (en) * 1988-11-19 1990-05-23 Arman Notghi Apparatus for the automatic adjustment of a plurality of temperature states in molecular biological methods
EP0375282B1 (en) * 1988-12-20 1996-04-17 Nippon Steel Corporation Blast furnace operation management method and apparatus
FR2642156B1 (en) * 1989-01-20 1994-05-20 Bertin Et Cie METHOD AND DEVICE FOR QUICK REGULATION OF A WALL TEMPERATURE
US5056427A (en) * 1989-03-15 1991-10-15 Seiko Instruments Inc. Sealing of cavity on reagent tray
US4950608A (en) * 1989-04-25 1990-08-21 Scinics Co., Ltd. Temperature regulating container
US5254314A (en) * 1989-08-24 1993-10-19 International Mould Engineering Microcentrifuge tube
AT394323B (en) * 1989-11-02 1992-03-10 Slt Labinstruments Gmbh TEMPERATURE CHAMBER, ESPECIALLY FOR TEMPERING THE CONTENT OF A MICROTITRATION PLATE, AND METHOD FOR CONTROLLING A HEATING CIRCUIT
CA2031912A1 (en) * 1989-12-22 1991-06-23 Robert Fred Pfost Heated cover device
JP3089577B2 (en) * 1993-01-18 2000-09-18 ヤマハ発動機株式会社 Engine supercharger
US5967001A (en) * 1998-01-26 1999-10-19 Qualicon Cap removing tool

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