CA2439813A1 - Porous beta-tricalcium phosphate granules and methods for producing same - Google Patents
Porous beta-tricalcium phosphate granules and methods for producing same Download PDFInfo
- Publication number
- CA2439813A1 CA2439813A1 CA002439813A CA2439813A CA2439813A1 CA 2439813 A1 CA2439813 A1 CA 2439813A1 CA 002439813 A CA002439813 A CA 002439813A CA 2439813 A CA2439813 A CA 2439813A CA 2439813 A1 CA2439813 A1 CA 2439813A1
- Authority
- CA
- Canada
- Prior art keywords
- porous
- beta
- tcp
- binder
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Compositions Of Oxide Ceramics (AREA)
Abstract
A porous .beta.-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 ~m, preferably 50-125 ~m. The porous .beta.-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous .beta.-TCP, and a bioactive agent and a binder. The invention also provides an implementable prosthetic device comprising a prosthetic implant having a surface region, a porous .beta.-TCP material disposed on the surface region optionally comprising at least a bioactive agent or a binder. Methods of producing the porous .beta.-TCP material and including bone formation are also provided.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002659188A CA2659188A1 (en) | 2001-03-02 | 2002-02-26 | Porous beta-tricalcium phosphate granules and methods for producing same |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/798,518 | 2001-03-02 | ||
US09/798,518 US20030049328A1 (en) | 2001-03-02 | 2001-03-02 | Porous beta-tricalcium phosphate granules and methods for producing same |
US09/960,789 | 2001-09-21 | ||
US09/960,789 US6949251B2 (en) | 2001-03-02 | 2001-09-21 | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
PCT/US2002/005827 WO2002070029A2 (en) | 2001-03-02 | 2002-02-26 | Porous beta-tricalcium phosphate granules and methods for producing same |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002659188A Division CA2659188A1 (en) | 2001-03-02 | 2002-02-26 | Porous beta-tricalcium phosphate granules and methods for producing same |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2439813A1 true CA2439813A1 (en) | 2002-09-12 |
CA2439813C CA2439813C (en) | 2009-06-16 |
Family
ID=27121998
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002659188A Abandoned CA2659188A1 (en) | 2001-03-02 | 2002-02-26 | Porous beta-tricalcium phosphate granules and methods for producing same |
CA002439813A Expired - Fee Related CA2439813C (en) | 2001-03-02 | 2002-02-26 | Porous beta-tricalcium phosphate granules and methods for producing same |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002659188A Abandoned CA2659188A1 (en) | 2001-03-02 | 2002-02-26 | Porous beta-tricalcium phosphate granules and methods for producing same |
Country Status (8)
Country | Link |
---|---|
US (4) | US6949251B2 (en) |
EP (1) | EP1372748B1 (en) |
JP (3) | JP2005505311A (en) |
AT (1) | ATE429256T1 (en) |
CA (2) | CA2659188A1 (en) |
DE (1) | DE60232061D1 (en) |
ES (1) | ES2325573T3 (en) |
WO (1) | WO2002070029A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7578845B2 (en) | 2002-04-29 | 2009-08-25 | Biomet Deutschland Gmbh | Structured composites as a matrix (scaffold) for the tissue engineering of bones |
CN116492450A (en) * | 2023-06-25 | 2023-07-28 | 朗肽生物制药股份有限公司 | Recombinant human basic fibroblast growth factor oral gel and preparation method thereof |
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2002
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- 2002-02-26 DE DE60232061T patent/DE60232061D1/en not_active Revoked
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- 2002-02-26 JP JP2002569200A patent/JP2005505311A/en active Pending
- 2002-02-26 ES ES02748362T patent/ES2325573T3/en not_active Expired - Lifetime
- 2002-02-26 AT AT02748362T patent/ATE429256T1/en not_active IP Right Cessation
-
2004
- 2004-06-10 JP JP2004173260A patent/JP2004262758A/en not_active Withdrawn
-
2005
- 2005-03-29 US US11/093,818 patent/US7390498B2/en not_active Expired - Lifetime
- 2005-03-29 US US11/093,429 patent/US7357941B2/en not_active Expired - Lifetime
-
2008
- 2008-02-21 US US12/072,105 patent/US8173149B2/en not_active Expired - Lifetime
- 2008-12-17 JP JP2008321674A patent/JP2009101174A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US7578845B2 (en) | 2002-04-29 | 2009-08-25 | Biomet Deutschland Gmbh | Structured composites as a matrix (scaffold) for the tissue engineering of bones |
CN116492450A (en) * | 2023-06-25 | 2023-07-28 | 朗肽生物制药股份有限公司 | Recombinant human basic fibroblast growth factor oral gel and preparation method thereof |
CN116492450B (en) * | 2023-06-25 | 2023-10-10 | 朗肽生物制药股份有限公司 | Recombinant human basic fibroblast growth factor oral gel and preparation method thereof |
Also Published As
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US20050170012A1 (en) | 2005-08-04 |
US20060292198A1 (en) | 2006-12-28 |
ES2325573T3 (en) | 2009-09-09 |
ATE429256T1 (en) | 2009-05-15 |
AU2002306592C1 (en) | 2002-09-19 |
JP2004262758A (en) | 2004-09-24 |
JP2005505311A (en) | 2005-02-24 |
DE60232061D1 (en) | 2009-06-04 |
US20090110743A1 (en) | 2009-04-30 |
CA2439813C (en) | 2009-06-16 |
US7390498B2 (en) | 2008-06-24 |
US20030180376A1 (en) | 2003-09-25 |
EP1372748A2 (en) | 2004-01-02 |
US8173149B2 (en) | 2012-05-08 |
JP2009101174A (en) | 2009-05-14 |
WO2002070029A2 (en) | 2002-09-12 |
CA2659188A1 (en) | 2002-09-12 |
US6949251B2 (en) | 2005-09-27 |
US7357941B2 (en) | 2008-04-15 |
WO2002070029A3 (en) | 2003-02-06 |
EP1372748B1 (en) | 2009-04-22 |
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