CA2457189A1 - Medical devices comprising nanomaterials and therapeutic methods utilizing the same - Google Patents
Medical devices comprising nanomaterials and therapeutic methods utilizing the same Download PDFInfo
- Publication number
- CA2457189A1 CA2457189A1 CA002457189A CA2457189A CA2457189A1 CA 2457189 A1 CA2457189 A1 CA 2457189A1 CA 002457189 A CA002457189 A CA 002457189A CA 2457189 A CA2457189 A CA 2457189A CA 2457189 A1 CA2457189 A1 CA 2457189A1
- Authority
- CA
- Canada
- Prior art keywords
- medical device
- nanoparticles
- nanomaterial
- stent
- medical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2/0108—Both ends closed, i.e. legs gathered at both ends
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L29/126—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2002/018—Filters implantable into blood vessels made from tubes or sheets of material, e.g. by etching or laser-cutting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0006—Rounded shapes, e.g. with rounded corners circular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/005—Rosette-shaped, e.g. star-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0067—Three-dimensional shapes conical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/90—Stent for heart valve
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/905—Specially adapted for travel through blood circulatory system
Abstract
The present invention provides medical devices comprising nanomaterials. By utilizing nanomaterials in the production thereof, the inventive medical devices can be provided with various advantageous properties and/or capabilities. Methods of producing the inventive medical devices are also provided. Inasmuch as the inventive devices are expected to provide certain advantages in their use, there is also provide a method of medical care, including methods of treatment or diagnosis, wherein the inventive devices a re brought into therapeutic contact with a body to be treated or diagnosed thereby.
Claims (37)
1) A medical device comprising at least one nanomaterial.
2) The medical device of claim 1, wherein the nanomaterial comprises at least one plurality of nanoparticles.
3) The medical device of claim 2, wherein the nanoparticles comprise carbon nanotubes or nanofibers.
4) The medical device of claim 3, wherein the medical device comprises multiple layers and the carbon nanotubes or nanofibers are interspersed between two adjacent layers.
5) The medical device of claim 4, wherein the medical device is catheter shafting.
6) The medical device of claim 1, wherein the nanomaterial comprises a nanocomposite material further comprising at least one plurality of nanoparticles and a matrix material.
7) The medical device of claim 6, wherein the device is an intralumen cardiovascular medical device.
8) The medical device of claim 7, wherein the matrix material comprises a thermoplastic material and the nanoparticles comprise a clay.
9) The medical device of claim 8, wherein the matrix material comprises a polyurethane and the clay comprises montmorillonite.
10) The medical device of claim 9, wherein the montmorillonite is functionalized with akylammonium.
11) The medical device of claim 8, wherein the medical device comprises an embolic filter.
12) A medical care kit, comprising at least one medical device and at least one nanomaterial provided in packaging.
13) The medical care kit of claim 12, wherein the at least one nanomaterial is included in at least a component of the at least one medical device.
14) The medical care kit of claim 12, wherein the nanomaterial comprises a first plurality of nanoparticles.
15) The medical care kit of claim 14, wherein the first plurality of nanoparticles comprise at least one biodegradable, biocompatible material, and at least one therapeutic agent.
16) The medical care kit of claim 15, wherein the first plurality of nanoparticles further comprise a magnetic material.
17) The medical care kit of claim 15, wherein the first plurality of nanoparticles further comprise a heat sensitive material.
18) The medical care kit of claim 13, wherein the medical device is a stent, the at least one nanomaterial comprises a coating applied to at least a portion of the stent and wherein the nanomaterial coating comprises a thermoplastic matrix material and magnetic nanoparticles.
19) A method of medical care comprising bringing a medical device into therapeutic contact with a body to effectuate a treatment or diagnosis thereof, wherein the medical device comprises at least one nanomaterial.
20) The method of claim 19, wherein the method of medical care is a method of treatment.
21) The method of claim 20, wherein the medical device is a transluminal medical device.
22) The method of claim 21, wherein the medical device is a stent delivery catheter.
23) The method of claim 22, wherein the stent delivery catheter is caused to deliver a stent to a desired treatment site.
24) The method of claim 23, further comprising causing a plurality of nanoparticles to be delivered to the treatment site.
25) The method of claim 24, wherein the nanoparticles operatively disposed relative to the stent at the time of delivery of the stent.
26) The method of claim 25, wherein the nanoparticles are a component of a nanomaterial coating provided on at least a portion of a surface of the stent.
27) The method of claim 24, wherein the nanoparticles are caused to be operatively disposed relative to the desired treatment site at substantially the same time as the stent is delivered.
28) The method of claim 24, wherein the nanoparticles are caused to be operatively disposed relative to the desired treatment site after the stent has been delivered.
29) The method of claim 28, wherein the step of causing the nanoparticles to be operatively disposed relative to the desired treatment site is repeated a plurality of times.
30) A method of making at least a component of a medical device, comprising:
providing a nanomaterial;
preparing at least a component of the medical device with the nanomaterial.
providing a nanomaterial;
preparing at least a component of the medical device with the nanomaterial.
31) The method of claim 30, wherein the nanomaterial comprises a first plurality of nanoparticles.
32) The method of claim 31, wherein the nanoparticles comprise carbon nanotubes, nanofibers, or nanowires.
33) The method of claim 32, wherein the nanomaterial is provided by electrospinning or electrohydrodynamically spraying a material onto a mold.
34) The method of claim 33, wherein the material is a carbonizable material that is electrohydrodynamically spun unto a mandrel and then carbonized to provide carbon nanotubes, nanowires, or nanofibers.
35) The method of claim 34, wherein the component of the medical device is provided by depositing a matrix material onto the mandrel and about at least a portion of the carbon nanoparticles.
36) The method of claim 32, wherein the component of the device prepared is a tie layer provided between a first and a second layer of the medical device.
37) The method of claim 36, wherein the tie layer is provide by causing at least a portion of the first layer of the medical device to come into contact with a solution comprising the carbon nanoparticles.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33133201P | 2001-09-28 | 2001-09-28 | |
US60/331,332 | 2001-09-28 | ||
US32762901P | 2001-10-05 | 2001-10-05 | |
US60/327,629 | 2001-10-05 | ||
PCT/US2002/030726 WO2003026532A2 (en) | 2001-09-28 | 2002-09-27 | Medical devices comprising nanomaterials and therapeutic methods utilizing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2457189A1 true CA2457189A1 (en) | 2003-04-03 |
CA2457189C CA2457189C (en) | 2011-08-09 |
Family
ID=26985974
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2456918A Expired - Fee Related CA2456918C (en) | 2001-09-28 | 2002-09-27 | Medical devices comprising nanocomposites |
CA2457189A Expired - Fee Related CA2457189C (en) | 2001-09-28 | 2002-09-27 | Medical devices comprising nanomaterials and therapeutic methods utilizing the same |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2456918A Expired - Fee Related CA2456918C (en) | 2001-09-28 | 2002-09-27 | Medical devices comprising nanocomposites |
Country Status (6)
Country | Link |
---|---|
US (5) | US7591831B2 (en) |
EP (4) | EP1429683B1 (en) |
JP (2) | JP2005503865A (en) |
AU (2) | AU2002360251A1 (en) |
CA (2) | CA2456918C (en) |
WO (2) | WO2003026532A2 (en) |
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2009
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2012
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WO2003026532A3 (en) | 2004-01-08 |
US8137373B2 (en) | 2012-03-20 |
CA2456918A1 (en) | 2003-06-19 |
EP1429683A2 (en) | 2004-06-23 |
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US9463103B2 (en) | 2016-10-11 |
US20030093107A1 (en) | 2003-05-15 |
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EP2266501B1 (en) | 2016-04-13 |
CA2457189C (en) | 2011-08-09 |
EP1429833A2 (en) | 2004-06-23 |
EP1429833B1 (en) | 2018-02-14 |
WO2003049795A2 (en) | 2003-06-19 |
EP2266501A3 (en) | 2011-04-27 |
AU2002360251A1 (en) | 2003-06-23 |
AU2002356530A1 (en) | 2003-04-07 |
JP2005503865A (en) | 2005-02-10 |
US20100010440A1 (en) | 2010-01-14 |
WO2003049795A3 (en) | 2003-12-31 |
EP2319453B1 (en) | 2016-07-20 |
EP2266501A2 (en) | 2010-12-29 |
US20120150109A1 (en) | 2012-06-14 |
JP2005511212A (en) | 2005-04-28 |
AU2002360251A8 (en) | 2003-06-23 |
US7591831B2 (en) | 2009-09-22 |
WO2003026532A2 (en) | 2003-04-03 |
EP1429683B1 (en) | 2014-12-24 |
US20090227944A1 (en) | 2009-09-10 |
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