CA2476653A1 - Cross-linked bioactive hydrogel matrices - Google Patents

Cross-linked bioactive hydrogel matrices Download PDF

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Publication number
CA2476653A1
CA2476653A1 CA002476653A CA2476653A CA2476653A1 CA 2476653 A1 CA2476653 A1 CA 2476653A1 CA 002476653 A CA002476653 A CA 002476653A CA 2476653 A CA2476653 A CA 2476653A CA 2476653 A1 CA2476653 A1 CA 2476653A1
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Canada
Prior art keywords
molecular weight
high molecular
weight component
hydrogel matrix
pastes
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Granted
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CA002476653A
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French (fr)
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CA2476653C (en
Inventor
Francis V. Lamberti
Richard Chris Klann
Ronald Stewart Hill
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Encelle Inc
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
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    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract

The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.
CA002476653A 2002-02-21 2003-02-21 Cross-linked bioactive hydrogel matrices Expired - Lifetime CA2476653C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35862502P 2002-02-21 2002-02-21
US60/358,625 2002-02-21
PCT/US2003/005511 WO2003072155A1 (en) 2002-02-21 2003-02-21 Cross-linked bioactive hydrogel matrices

Publications (2)

Publication Number Publication Date
CA2476653A1 true CA2476653A1 (en) 2003-09-04
CA2476653C CA2476653C (en) 2009-01-27

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Family Applications (2)

Application Number Title Priority Date Filing Date
CA002476656A Expired - Fee Related CA2476656C (en) 2002-02-21 2003-02-21 Immobilized bioactive hydrogel matrices as surface coatings
CA002476653A Expired - Lifetime CA2476653C (en) 2002-02-21 2003-02-21 Cross-linked bioactive hydrogel matrices

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002476656A Expired - Fee Related CA2476656C (en) 2002-02-21 2003-02-21 Immobilized bioactive hydrogel matrices as surface coatings

Country Status (10)

Country Link
US (9) US7303814B2 (en)
EP (2) EP1476202B1 (en)
JP (2) JP4489437B2 (en)
AT (2) ATE410198T1 (en)
AU (2) AU2003213253B2 (en)
CA (2) CA2476656C (en)
DE (2) DE60325827D1 (en)
ES (2) ES2314187T3 (en)
NZ (2) NZ535369A (en)
WO (2) WO2003072157A1 (en)

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CN103638553A (en) * 2013-11-27 2014-03-19 首都医科大学 Hyaluronic acid hydrogel biological stent material having oriented channels and preparation method thereof
CN114644739A (en) * 2020-12-18 2022-06-21 武汉理工大学 High-adhesion hydrogel, preparation method and application

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