CA2476656A1 - Immobilized bioactive hydrogel matrices as surface coatings - Google Patents

Immobilized bioactive hydrogel matrices as surface coatings Download PDF

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Publication number
CA2476656A1
CA2476656A1 CA002476656A CA2476656A CA2476656A1 CA 2476656 A1 CA2476656 A1 CA 2476656A1 CA 002476656 A CA002476656 A CA 002476656A CA 2476656 A CA2476656 A CA 2476656A CA 2476656 A1 CA2476656 A1 CA 2476656A1
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CA
Canada
Prior art keywords
molecular weight
high molecular
bioactive hydrogel
surface coatings
hydrogel matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002476656A
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French (fr)
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CA2476656C (en
Inventor
Francis V. Lamberti
Richard Chris Klann
Ronald Stewart Hill
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Encelle Inc
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Individual
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Publication of CA2476656A1 publication Critical patent/CA2476656A1/en
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Publication of CA2476656C publication Critical patent/CA2476656C/en
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Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
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    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
    • B29C39/003—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor characterised by the choice of material
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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    • A61L2420/00—Materials or methods for coatings medical devices
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7532—Artificial members, protheses
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    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T428/2913—Rod, strand, filament or fiber
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    • Y10T428/294—Coated or with bond, impregnation or core including metal or compound thereof [excluding glass, ceramic and asbestos]
    • Y10T428/2942—Plural coatings
    • Y10T428/2947—Synthetic resin or polymer in plural coatings, each of different type
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31551—Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31786—Of polyester [e.g., alkyd, etc.]

Abstract

The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.
CA002476656A 2002-02-21 2003-02-21 Immobilized bioactive hydrogel matrices as surface coatings Expired - Fee Related CA2476656C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35862502P 2002-02-21 2002-02-21
US60/358,625 2002-02-21
PCT/US2003/005072 WO2003072157A1 (en) 2002-02-21 2003-02-21 Immobilized bioactive hydrogel matrices as surface coatings

Publications (2)

Publication Number Publication Date
CA2476656A1 true CA2476656A1 (en) 2003-09-04
CA2476656C CA2476656C (en) 2008-11-25

Family

ID=27765970

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002476656A Expired - Fee Related CA2476656C (en) 2002-02-21 2003-02-21 Immobilized bioactive hydrogel matrices as surface coatings
CA002476653A Expired - Lifetime CA2476653C (en) 2002-02-21 2003-02-21 Cross-linked bioactive hydrogel matrices

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002476653A Expired - Lifetime CA2476653C (en) 2002-02-21 2003-02-21 Cross-linked bioactive hydrogel matrices

Country Status (10)

Country Link
US (9) US7303814B2 (en)
EP (2) EP1476204B1 (en)
JP (2) JP4489437B2 (en)
AT (2) ATE410198T1 (en)
AU (2) AU2003213253B2 (en)
CA (2) CA2476656C (en)
DE (2) DE60325827D1 (en)
ES (2) ES2318115T3 (en)
NZ (2) NZ535136A (en)
WO (2) WO2003072157A1 (en)

Families Citing this family (292)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050163818A1 (en) * 1996-11-05 2005-07-28 Hsing-Wen Sung Drug-eluting device chemically treated with genipin
US20040081704A1 (en) 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
AU2002328762B2 (en) * 2001-10-11 2007-08-23 Straumann Holding Ag Osteophilic implants
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
US20080086792A1 (en) 2006-10-13 2008-04-17 Thomas Charles Kuracina Method and apparatus for diverting sweat, liquid, moisture or the like from an eye
JP4489437B2 (en) 2002-02-21 2010-06-23 エンセル，インコーポレイテッド Immobilized bioactive hydrogel matrix as a surface coating
GB0212667D0 (en) * 2002-05-31 2002-07-10 Psimedica Ltd Orthopaedic scaffolds for tissue engineering
US7299805B2 (en) 2002-06-07 2007-11-27 Marctec, Llc Scaffold and method for implanting cells
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
CN1290483C (en) * 2002-06-20 2006-12-20 多克萨股份公司 System for a dental filling material or implant material, and powdered material, hydration liquid, implant material and method of achieving bonding
US7550004B2 (en) * 2002-08-20 2009-06-23 Cook Biotech Incorporated Endoluminal device with extracellular matrix material and methods
IL152030A0 (en) * 2002-09-30 2003-05-29 Nvr Labs Ltd Neural & Vascular Cohesive biopolymers comprising sulfated polysaccharides and fibrillar proteins and use thereof for tissue repair
CN1739017B (en) 2002-12-11 2011-04-06 弗罗桑医疗设备公司 Gelatine-based materials as swabs
US6982298B2 (en) 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8137688B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8138265B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
DE10318801A1 (en) * 2003-04-17 2004-11-04 Aesculap Ag & Co. Kg Flat implant and its use in surgery
EP1648298A4 (en) 2003-07-25 2010-01-13 Dexcom Inc Oxygen enhancing membrane systems for implantable devices
SE0302652D0 (en) * 2003-10-06 2003-10-06 Amersham Biosciences Ab Attachment of cells to surfaces
EP2514445B1 (en) 2003-10-22 2018-07-18 Encelle, Inc. Bioactive hydrogel compositions for the regeneration of connective tissue
JP4510425B2 (en) * 2003-10-30 2010-07-21 静志 永森 Cell culture method by three-dimensional culture
EP1689321B1 (en) * 2003-11-07 2017-01-04 The University of Connecticut Artificial tissue systems and uses thereof
WO2005065079A2 (en) * 2003-11-10 2005-07-21 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
ATE475434T1 (en) 2004-01-30 2010-08-15 Ferrosan As HEMOSTATIC SPRAYS AND COMPOSITIONS
FR2865737B1 (en) * 2004-02-03 2006-03-31 Anteis Sa BIOCOMPATIBLE RETICLE GEL
DE102004019241A1 (en) 2004-04-16 2005-11-03 Cellmed Ag Injectable cross-linked and uncrosslinked alginates and their use in medicine and aesthetic surgery
US8337482B2 (en) 2004-04-19 2012-12-25 The Invention Science Fund I, Llc System for perfusion management
US8361013B2 (en) 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US9011329B2 (en) 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US9801527B2 (en) 2004-04-19 2017-10-31 Gearbox, Llc Lumen-traveling biological interface device
US7857767B2 (en) 2004-04-19 2010-12-28 Invention Science Fund I, Llc Lumen-traveling device
US8019413B2 (en) 2007-03-19 2011-09-13 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US7850676B2 (en) 2004-04-19 2010-12-14 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US8092549B2 (en) 2004-09-24 2012-01-10 The Invention Science Fund I, Llc Ciliated stent-like-system
US8353896B2 (en) 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
US20050245905A1 (en) * 2004-04-30 2005-11-03 Schmidt Steven P Local drug-delivery system
US8696564B2 (en) 2004-07-09 2014-04-15 Cardiac Pacemakers, Inc. Implantable sensor with biocompatible coating for controlling or inhibiting tissue growth
WO2006005340A1 (en) 2004-07-09 2006-01-19 Ferrosan A/S Haemostatic composition comprising hyaluronic acid
FR2877669B1 (en) * 2004-11-05 2007-01-26 Inst Nat Sciences Appliq COVALENT GRAFTING OF HYDROPHOBIC SUBSTANCES ON COLLAGEN
US20090088846A1 (en) 2007-04-17 2009-04-02 David Myung Hydrogel arthroplasty device
ITTO20040918A1 (en) * 2004-12-29 2005-03-29 Luigi Ambrosio POLYMERIC HYDROGEL BIODEGRADABLE ABSORBERS AND PROCEDURE FOR THEIR PREPARATION
US20080171070A1 (en) * 2005-01-31 2008-07-17 Pierre Schaaf Polyelectrolyte Multilayer Film, Preparation And Uses Thereof
WO2006089167A1 (en) * 2005-02-18 2006-08-24 Cartilix, Inc. Glucosamine materials
US8552100B2 (en) * 2005-02-23 2013-10-08 The Regents Of The University Of California Flexible hydrogel-based functional composite materials
WO2006091675A2 (en) * 2005-02-23 2006-08-31 Surmodics, Inc. Implantable medical articles having laminin coatings and methods of use
EP1887967A2 (en) * 2005-04-25 2008-02-20 Eric F. Bernstein Dermal fillers for biomedical applications in mammals and methods of using the same
EP1880738A1 (en) * 2005-05-13 2008-01-23 Netech Inc. Medical composition for promotion of skin regeneration
US8475886B2 (en) 2005-08-05 2013-07-02 Corning Incorporated Methods for producing surfaces that resist non-specific protein binding and cell attachment
DE602006018023D1 (en) * 2005-08-08 2010-12-16 Angstrom Medica Inc CEMENT PRODUCTS AND METHOD FOR THE PRODUCTION AND USE THEREOF
JP5213104B2 (en) * 2005-09-16 2013-06-19 和雄 遊道 Biomaterials for regenerative medicine
AU2006293426A1 (en) * 2005-09-22 2007-03-29 Hadasit Medical Research Services & Development Limited Dextran and arabinogalactan conjugates of therapeutically active compounds
US20070190165A1 (en) * 2005-10-21 2007-08-16 Brey Eric M Tissue-specific basement membrane gels
WO2007050314A2 (en) * 2005-10-24 2007-05-03 Hosheng Tu Medical device with living cell sheet
TWI363800B (en) * 2006-02-06 2012-05-11 Univ Tamkang Biomedical device having crosslinked biopolymer micro pattern and preparation thereof
ATE504236T1 (en) * 2006-02-27 2011-04-15 Edwards Lifesciences Corp WATER GEL FOR INTRAVENOUS AMPEROMETRIC BIOSENSOR
US20080058785A1 (en) 2006-04-12 2008-03-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
US20120035540A1 (en) 2006-04-12 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Event-based control of a lumen traveling device
US8021677B2 (en) * 2006-05-12 2011-09-20 Gore Enterprise Holdings, Inc. Immobilized biologically active entities having a high degree of biological activity
US20080108138A1 (en) * 2006-06-13 2008-05-08 Vermette Patrick Bioactive compositions and their use in cell patterning
US8377091B2 (en) 2006-06-15 2013-02-19 Microvention, Inc. Embolization device constructed from expansile polymer
DE102006033167A1 (en) 2006-07-10 2008-01-24 Gelita Ag Use of gelatin and a crosslinking agent for the preparation of a crosslinking medical adhesive
DE102006033168A1 (en) 2006-07-10 2008-01-17 Gelita Ag Use of gelatin and a crosslinking agent for the preparation of a crosslinking therapeutic composition
CA2657435A1 (en) 2006-07-10 2008-07-03 Medipacs, Inc. Super elastic epoxy hydrogel
AU2012200560B2 (en) * 2006-08-18 2014-07-31 Elanco New Zealand Method for Reducing the Incidence of Mastitis
NZ549249A (en) * 2006-08-18 2009-10-30 Univ Massey Methods for reducing the incidence of mastitis by administration of keratin
CA2663417A1 (en) * 2006-09-13 2008-03-20 Southeastern Medical Technologies, Llc Methods and compositions for sealing and adhering biological tissues and medical uses thereof
US7914819B1 (en) * 2006-10-19 2011-03-29 Clemson University Research Foundation Polysaccharide-based biomaterials
US9017664B2 (en) 2006-12-15 2015-04-28 Lifebond Ltd. Gelatin-transglutaminase hemostatic dressings and sealants
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
DK2097116T3 (en) 2006-12-22 2013-01-02 Medidom Lab In situ system for intra-articular cartilage and bone tissue healing
US7751863B2 (en) 2007-02-06 2010-07-06 Glumetrics, Inc. Optical determination of ph and glucose
JPWO2008096547A1 (en) * 2007-02-07 2010-05-20 焼津水産化学工業株式会社 Antitumor agent composition containing tissue-retaining chitosan gel
US8529951B1 (en) 2007-02-21 2013-09-10 Anand Ramamurthi Elastogenic cues and methods for using same
US8679859B2 (en) * 2007-03-12 2014-03-25 State of Oregon by and through the State Board of Higher Education on behalf of Porland State University Method for functionalizing materials and devices comprising such materials
JP5517919B2 (en) 2007-05-10 2014-06-11 グルメトリクス、 インク． Balanced non-consumable fluorescent sensor for immediate intravascular glucose measurement
EP1997457B1 (en) * 2007-06-01 2010-11-10 Allergan, Inc. Biological tissue growth support through induced tensile stress
WO2008157372A2 (en) 2007-06-14 2008-12-24 Massachusetts Institute Of Technology Self assembled films for protein and drug delivery applications
US8932619B2 (en) * 2007-06-27 2015-01-13 Sofradim Production Dural repair material
US8480651B2 (en) * 2007-08-02 2013-07-09 Covidien Lp Cannula system
EP2178949B1 (en) * 2007-08-14 2017-12-13 Cook Medical Technologies LLC Photoactivated crosslinking of a protein or peptide
US8815973B2 (en) * 2007-08-28 2014-08-26 Pioneer Surgical Technology, Inc. Cement products and methods of making and using the same
US20090068250A1 (en) * 2007-09-07 2009-03-12 Philippe Gravagna Bioresorbable and biocompatible compounds for surgical use
US20100285086A1 (en) * 2007-10-09 2010-11-11 Lee Mark H Biomimetic Extracellular Matrices
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
US8414924B2 (en) * 2007-10-10 2013-04-09 Kyoto University Preparation for treating heart disease used in cell therapy
WO2009067601A1 (en) 2007-11-20 2009-05-28 Pioneer Surgical Orthobiologics, Inc. Cryopreservation of cells using cross-linked bioactive hydrogel matrix particles
WO2009067626A1 (en) 2007-11-21 2009-05-28 Glumetrics, Inc. Use of an equilibrium intravascular sensor to achieve tight glycemic control
US9308068B2 (en) 2007-12-03 2016-04-12 Sofradim Production Implant for parastomal hernia
EP2227635A2 (en) 2007-12-03 2010-09-15 Medipacs, Inc. Fluid metering device
US8470035B2 (en) 2007-12-21 2013-06-25 Microvention, Inc. Hydrogel filaments for biomedical uses
EP2249891B1 (en) 2008-02-13 2016-05-25 The Cleveland Clinic Foundation Molecular enhancement of extracellular matrix and methods of use
EP2247645B1 (en) * 2008-02-13 2017-12-06 Hyperbranch Medical Technology, Inc. Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
US8642831B2 (en) 2008-02-29 2014-02-04 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
WO2009135029A2 (en) 2008-04-30 2009-11-05 The Cleveland Clinic Foundation Compositions and methods to treat urinary incontinence
CA2728187C (en) 2008-06-18 2014-04-29 Lifebond Ltd Improved cross-linked compositions
US9242026B2 (en) 2008-06-27 2016-01-26 Sofradim Production Biosynthetic implant for soft tissue repair
EP3357519B1 (en) * 2008-07-02 2019-03-13 Allergan, Inc. Compositions for soft tissue filling and regeneration
US8883915B2 (en) 2008-07-07 2014-11-11 Biomimedica, Inc. Hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
WO2010017282A1 (en) 2008-08-05 2010-02-11 Biomimedica, Inc. Polyurethane-grafted hydrogels
ES2829971T3 (en) 2008-09-02 2021-06-02 Tautona Group Lp Hyaluronic acid threads and / or derivatives thereof, methods to manufacture them and uses thereof
CN102202611B (en) * 2008-10-21 2015-07-22 Ww技术股份公司 Fusion device and tool set for fusing a human or animal joint
AU2009333168C1 (en) 2008-12-17 2017-04-20 The Johns Hopkins University Biocompatible polysaccharide-based hydrogels
US8469779B1 (en) 2009-01-02 2013-06-25 Lifecell Corporation Method for debristling animal skin
US20100249924A1 (en) * 2009-03-27 2010-09-30 Allergan, Inc. Bioerodible matrix for tissue involvement
EP2236520A1 (en) * 2009-03-31 2010-10-06 Leukocare Ag Stabilizing composition for immobilized biomolecules
US9414864B2 (en) 2009-04-15 2016-08-16 Warsaw Orthopedic, Inc. Anterior spinal plate with preformed drug-eluting device affixed thereto
US9078712B2 (en) 2009-04-15 2015-07-14 Warsaw Orthopedic, Inc. Preformed drug-eluting device to be affixed to an anterior spinal plate
US9463260B2 (en) * 2009-06-29 2016-10-11 Covidien Lp Self-sealing compositions
FR2949688B1 (en) 2009-09-04 2012-08-24 Sofradim Production FABRIC WITH PICOTS COATED WITH A BIORESORBABLE MICROPOROUS LAYER
WO2011032011A1 (en) 2009-09-10 2011-03-17 Medipacs, Inc. Low profile actuator and improved method of caregiver controlled administration of therapeutics
WO2011041546A1 (en) 2009-09-30 2011-04-07 Glumetrics, Inc. Sensors with thromboresistant coating
WO2011040969A1 (en) * 2009-09-30 2011-04-07 Massachusetts Institute Of Technology Compositions and methods for the treatment of atherosclerosis and other related diseases
US20110093057A1 (en) * 2009-10-16 2011-04-21 Confluent Surgical, Inc. Mitigating Thrombus Formation On Medical Devices By Influencing pH Microenvironment Near The Surface
EP2493367B1 (en) 2009-10-26 2019-03-13 Microvention, Inc. Embolization device constructed from expansile polymer
US8467843B2 (en) 2009-11-04 2013-06-18 Glumetrics, Inc. Optical sensor configuration for ratiometric correction of blood glucose measurement
WO2011057131A1 (en) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Polysaccharide based hydrogels
NZ599527A (en) 2009-11-09 2014-04-30 Spotlight Technology Partners Llc Fragmented hydrogels
EP2504432B1 (en) 2009-11-10 2018-02-14 The Johns Hopkins University Hydrogel-based vascular lineage cell growth media and uses thereof
DK2515957T3 (en) 2009-12-22 2015-11-09 Lifebond Ltd CHANGE OF ENZYMATIC CIRCULATORS FOR MANAGEMENT OF CHARACTERISTICS BY CIRCUIT MATRIX
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
WO2011088213A1 (en) * 2010-01-15 2011-07-21 University Of Utah Research Foundation Crosslinked hydrogels and methods of making and using thereof
WO2011090224A1 (en) * 2010-01-21 2011-07-28 서울대학교산학협력단 Method for coating a medical product with a pharmaceutical substance
US9500186B2 (en) 2010-02-01 2016-11-22 Medipacs, Inc. High surface area polymer actuator with gas mitigating components
WO2011096402A1 (en) * 2010-02-03 2011-08-11 独立行政法人物質・材料研究機構 Biocompatible device
US20110229457A1 (en) * 2010-03-12 2011-09-22 Surmodics, Inc. Injectable drug delivery system
EP3078388B1 (en) 2010-03-22 2019-02-20 Allergan, Inc. Cross-linked hydrogels for soft tissue augmentation
US10143776B2 (en) 2010-06-30 2018-12-04 The Johns Hopkins University Functional vascularization with biocompatible polysaccharide-based hydrogels
AU2011287215B2 (en) 2010-08-05 2015-09-10 Lifebond Ltd. Dry composition wound dressings and adhesives
US8697056B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US8945664B1 (en) 2010-10-29 2015-02-03 Greatbatch Ltd. Mechanical stability of the biomimetic coating by cross linking of surfactant polymer
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
CA2817584C (en) 2010-11-15 2018-01-02 Zimmer Orthobiologics, Inc. Bone void fillers
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US8637067B1 (en) 2011-03-10 2014-01-28 Lifecell Corporation Elastic tissue matrix derived hydrogel
FR2972626B1 (en) 2011-03-16 2014-04-11 Sofradim Production PROSTHETIC COMPRISING A THREE-DIMENSIONAL KNIT AND ADJUSTED
EP2508212A1 (en) 2011-04-05 2012-10-10 Universitätsklinikum Freiburg Biocompatible and biodegradable gradient layer system for regenerative medicine and for tissue support
EP2696908B1 (en) 2011-04-14 2015-03-11 Lifecell Corporation Regenerative materials
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
WO2012149492A1 (en) * 2011-04-27 2012-11-01 Massachusetts Institute Of Technology Coating compositions, methods and coated devices
BR112013030086A2 (en) * 2011-05-24 2022-03-03 Purdue Research Foundation Synthetic Peptideoglycans Binding to Hyaluronic Acid, Engineered Collagen Matrix and Their Uses
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
KR102238406B1 (en) 2011-06-03 2021-04-08 알러간 인더스트리 에스에이에스 Dermal filler compositions including antioxidants
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
FR2977790B1 (en) 2011-07-13 2013-07-19 Sofradim Production PROSTHETIC FOR UMBILIC HERNIA
FR2977789B1 (en) 2011-07-13 2013-07-19 Sofradim Production PROSTHETIC FOR UMBILIC HERNIA
US9089523B2 (en) 2011-07-28 2015-07-28 Lifecell Corporation Natural tissue scaffolds as tissue fillers
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
DK2760432T3 (en) 2011-09-27 2019-06-11 Medtronic Minimed Inc PROCEDURE FOR FUNCTIONALIZING A POROSE MEMBRANE COVER ON AN OPTICAL SENSOR FOR PROMOTING ANTITROMBOGENT INTERMEDIATE
CA2849052C (en) 2011-09-30 2019-11-05 Sofradim Production Reversible stiffening of light weight mesh
WO2013046057A1 (en) 2011-09-30 2013-04-04 Sofradim Production Multilayer implants for delivery of therapeutic agents
US20130103157A1 (en) 2011-10-03 2013-04-25 Lampros Kourtis Polymeric adhesive for anchoring compliant materials to another surface
US20130102690A1 (en) * 2011-10-21 2013-04-25 Nitta Casings Inc. Collagen-polysaccharide materials mimicking blood vessels, tissues and bones for medical, pharmaceutical and orthopedic applications, and processes for producing the same
JP6095675B2 (en) * 2011-10-28 2017-03-15 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ Non-aqueous compositions for bone hemostasis and methods for using and manufacturing them
KR20140097256A (en) 2011-11-02 2014-08-06 할사이온, 인크. Methods and compositions for wound treatment
EP2776068A4 (en) * 2011-11-13 2015-05-20 Suneris Inc In-situ cross-linkable polymeric compositions and methods thereof
CA2856512A1 (en) 2011-11-21 2013-05-30 Biomimedica, Inc. Systems, devices, and methods for anchoring orthopaedic implants to bone
ES2726105T3 (en) 2011-12-20 2019-10-01 Lifecell Corp Fluidizable fabric products
US9532863B2 (en) 2011-12-20 2017-01-03 Lifecell Corporation Sheet tissue products
US8940317B2 (en) 2011-12-23 2015-01-27 Pioneer Surgical Technology Continuous matrix with osteoconductive particles dispersed therein, method of forming thereof, and method of regenerating bone therewith
FR2985271B1 (en) 2011-12-29 2014-01-24 Sofradim Production KNITTED PICOTS
FR2985170B1 (en) 2011-12-29 2014-01-24 Sofradim Production PROSTHESIS FOR INGUINAL HERNIA
DK2806907T3 (en) 2012-01-24 2019-02-18 Lifecell Corp EXTENDED TISSUE MATRIX
EP2822474B1 (en) 2012-03-06 2018-05-02 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
CN104302689A (en) 2012-03-14 2015-01-21 麦德医像公司 Smart polymer materials with excess reactive molecules
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
US10278927B2 (en) 2012-04-23 2019-05-07 Massachusetts Institute Of Technology Stable layer-by-layer coated particles
BR112014026090A8 (en) 2012-04-24 2019-08-27 Lifecell Corp flowable tissue matrix composition
EP2977066A3 (en) 2012-06-12 2016-07-27 Ferrosan Medical Devices A/S Dry haemostatic composition
BR112014031223B1 (en) 2012-06-14 2023-03-14 Microvention, Inc POLYMER TREATMENT COMPOSITIONS
WO2013191510A1 (en) * 2012-06-22 2013-12-27 서울대학교 산학협력단 Medical metal material for in vivo insertion, comprising in vivo movement-preventing means
ES2753156T3 (en) 2012-07-13 2020-04-07 Lifecell Corp Improved adipose tissue treatment procedures
CN102784164A (en) * 2012-07-27 2012-11-21 中国海洋大学 Application of polysaccharide sulphate to preparation of tumor treatment neovascularization inhibitors and vascular disrupting agents
FR2994185B1 (en) 2012-08-02 2015-07-31 Sofradim Production PROCESS FOR THE PREPARATION OF A POROUS CHITOSAN LAYER
US20140072611A1 (en) 2012-09-07 2014-03-13 Fibrocell Technologies, Inc. Methods and Compositions for Treating Post-Cardial Infarction Damage
US9644076B2 (en) * 2012-09-25 2017-05-09 Max-Planck-Gesellschaft zur Foerderung der Wissenschafen e. V. Cross-linkers for hydrogels, hydrogels including these cross-linkers and applications thereof
FR2995788B1 (en) 2012-09-25 2014-09-26 Sofradim Production HEMOSTATIC PATCH AND PREPARATION METHOD
FR2995779B1 (en) 2012-09-25 2015-09-25 Sofradim Production PROSTHETIC COMPRISING A TREILLIS AND A MEANS OF CONSOLIDATION
FR2995778B1 (en) 2012-09-25 2015-06-26 Sofradim Production ABDOMINAL WALL REINFORCING PROSTHESIS AND METHOD FOR MANUFACTURING THE SAME
WO2014052376A1 (en) 2012-09-26 2014-04-03 Lifecell Corporation Processed adipose tissue
US10159555B2 (en) 2012-09-28 2018-12-25 Sofradim Production Packaging for a hernia repair device
US9078950B2 (en) 2012-10-15 2015-07-14 Microvention, Inc. Polymeric treatment compositions
CA2895482A1 (en) * 2012-12-18 2014-06-26 Novabone Products, Llc Bioactive glass with ethylene oxide propylene oxide block copolymers
CN103007346A (en) * 2012-12-26 2013-04-03 天津市赛宁生物工程技术有限公司 Anti-adhesion endocranium prepared by physical sedimentation method
US9682177B2 (en) * 2012-12-28 2017-06-20 Boston Scientific Scimed, Inc. Methods, compositions and kits for surgical repair
US9446166B2 (en) 2013-01-24 2016-09-20 Ethicon, Inc. Fibrin sealant compositions with chemical crosslinking
CN104994893B (en) 2013-02-06 2018-01-05 生命细胞公司 Method for the partial modification of tissue products
US9347037B2 (en) * 2013-02-11 2016-05-24 Evan Masataka Masutani Methods and apparatus for building complex 3D scaffolds and biomimetic scaffolds built therefrom
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
WO2014164815A2 (en) 2013-03-12 2014-10-09 Allergan, Inc. Adipose tissue combinations, devices, and uses thereof
US10130288B2 (en) 2013-03-14 2018-11-20 Cell and Molecular Tissue Engineering, LLC Coated sensors, and corresponding systems and methods
US10405961B2 (en) 2013-03-14 2019-09-10 Cell and Molecular Tissue Engineering, LLC Coated surgical mesh, and corresponding systems and methods
US9463244B2 (en) 2013-03-15 2016-10-11 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
FR3006581B1 (en) 2013-06-07 2016-07-22 Sofradim Production PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY
FR3006578B1 (en) 2013-06-07 2015-05-29 Sofradim Production PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY
GB201310894D0 (en) 2013-06-19 2013-07-31 Univ Singapore Surface modification of medical or veterinary devices
EP3010419B1 (en) 2013-06-21 2020-05-20 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US9290115B2 (en) 2013-09-10 2016-03-22 Bae Industries, Inc. Seat assembly with moveable seatback
WO2015048774A2 (en) * 2013-09-30 2015-04-02 Bioactive Regenerative Therapeutics, Inc. Biomimetic hybrid gel compositions and methods of use
US9248384B2 (en) 2013-10-02 2016-02-02 Allergan, Inc. Fat processing system
CN103520764B (en) * 2013-10-29 2015-06-03 成都迪康中科生物医学材料有限公司 Functional dressing, and preparation method and application thereof
KR20150053606A (en) * 2013-11-08 2015-05-18 세원셀론텍(주) A gum-type materials with the enforced physical and biological properties through naturally crosslinking of collagen and hyaluronic acid, its manufacture and its usage method
CN103638553A (en) * 2013-11-27 2014-03-19 首都医科大学 Hyaluronic acid hydrogel biological stent material having oriented channels and preparation method thereof
AU2014361291B2 (en) 2013-12-11 2017-11-30 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
US11000285B2 (en) * 2013-12-17 2021-05-11 3Dt Holdings, Llc Luminal grafts and methods of making and using the same
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
WO2015167752A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers including active agents
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US10493107B2 (en) * 2014-06-09 2019-12-03 Cornell University Implantable therapeutic delivery system and methods thereof
EP3000489B1 (en) 2014-09-24 2017-04-05 Sofradim Production Method for preparing an anti-adhesion barrier film
EP3000432B1 (en) 2014-09-29 2022-05-04 Sofradim Production Textile-based prosthesis for treatment of inguinal hernia
EP3000433B1 (en) 2014-09-29 2022-09-21 Sofradim Production Device for introducing a prosthesis for hernia treatment into an incision and flexible textile based prosthesis
US10722444B2 (en) 2014-09-30 2020-07-28 Allergan Industrie, Sas Stable hydrogel compositions including additives
JP6726852B2 (en) 2014-10-13 2020-07-22 フェッローサン メディカル ディバイス エー／エス Dry composition for use in hemostasis and wound healing
EP3029189B1 (en) 2014-12-05 2021-08-11 Sofradim Production Prosthetic porous knit, method of making same and hernia prosthesis
JP6747650B2 (en) 2014-12-24 2020-08-26 フェロサン メディカル デバイシーズ エイ／エス Syringe for holding and mixing the first substance and the second substance
US10751448B2 (en) * 2015-01-12 2020-08-25 Wake Forest University Health Sciences Multi-layer skin substitute products and methods of making and using the same
AU2016214910B2 (en) 2015-02-06 2021-10-07 The University Of British Columbia Engineered tissue substitute system
EP3059255B1 (en) 2015-02-17 2020-05-13 Sofradim Production Method for preparing a chitosan-based matrix comprising a fiber reinforcement member
BR112017019272A2 (en) 2015-03-10 2018-05-02 Allergan Pharmaceuticals Holdings Ireland Unlimited Company multiple needle injector
JP2018511684A (en) 2015-04-03 2018-04-26 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ Gelled dextran ether
JP2018513249A (en) 2015-04-03 2018-05-24 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ Oxidized dextran
EP3085337B1 (en) 2015-04-24 2022-09-14 Sofradim Production Prosthesis for supporting a breast structure
US10126298B2 (en) 2015-05-04 2018-11-13 Arman Nabatian Hydrogels containing embedded substrates for targeted binding of molecules
CA3177726A1 (en) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation
EP3106185B1 (en) 2015-06-19 2018-04-25 Sofradim Production Synthetic prosthesis comprising a knit and a non porous film and method for forming same
JP6747651B2 (en) 2015-07-03 2020-08-26 フェロサン メディカル デバイシーズ エイ／エス Syringe for holding vacuum in storage and for mixing two components
CN107028872B (en) * 2015-07-21 2020-05-22 中国科学院化学研究所 Composite hydrogel, preparation method and application thereof
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
KR101734489B1 (en) 2015-08-11 2017-05-11 (주)헵틸와이 Medical catheter comprising oxidized polysaccharide and hydrophilic polymer-containing coating layer and manufacturing method thereof
WO2017062762A2 (en) * 2015-10-07 2017-04-13 Sigmon John C Methods, medical devices and kits for modifying the luminal profile of a body vessel
WO2017075055A1 (en) * 2015-10-26 2017-05-04 President And Fellows Of Harvard College Reduced and oxidized polysaccharides and methods of use thereof
CN105363070B (en) * 2015-11-25 2016-11-23 中国石油大学(华东) A kind of hydrogel that can be used for cell adhesion and preparation method thereof
GB201523102D0 (en) * 2015-12-30 2016-02-10 Augmented Optics Ltd Electrically active hydrophilic bio-polymers
EP3195830B1 (en) 2016-01-25 2020-11-18 Sofradim Production Prosthesis for hernia repair
JP6820912B2 (en) * 2016-03-28 2021-01-27 富士フイルム株式会社 Preparations, preparation parts and methods for manufacturing them
RU2725968C2 (en) 2016-04-08 2020-07-07 Аллерган, Инк. Aspiration-injection device
SG11201809197XA (en) 2016-04-27 2018-11-29 Anika Therapeutics Inc Compositions for use in treating tendon degeneration
US9745439B1 (en) 2016-05-10 2017-08-29 Qatar Foundation For Education, Science And Community Development Methods of forming aerogels
US10792394B2 (en) 2016-06-03 2020-10-06 Lifecell Corporation Methods for localized modification of tissue products
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
EP3312325B1 (en) 2016-10-21 2021-09-22 Sofradim Production Method for forming a mesh having a barbed suture attached thereto and the mesh thus obtained
US20180133368A1 (en) * 2016-11-15 2018-05-17 The Board Of Regents Of The University Of Texas System 3D Printed Ti-6Al-4V Scaffolds with Hydrogel Matrix
US20200179569A1 (en) * 2016-11-25 2020-06-11 Stimos Gmbh Material for a bone implant and method for producing the same
AU2017382173A1 (en) 2016-12-22 2019-06-06 Lifecell Corporation Devices and methods for tissue cryomilling
CN107050521B (en) * 2017-04-27 2020-10-09 天新福（北京）医疗器材股份有限公司 Double-layer collagen dermal scaffold and preparation method thereof
EP3398554A1 (en) 2017-05-02 2018-11-07 Sofradim Production Prosthesis for inguinal hernia repair
WO2019017987A1 (en) * 2017-07-18 2019-01-24 Modern Meadow, Inc. Biofabricated leather articles, and methods thereof
JP2020533070A (en) 2017-09-08 2020-11-19 パイオニア サージカル テクノロジー インコーポレイテッド Intervertebral implants, instruments, and methods
USD907771S1 (en) 2017-10-09 2021-01-12 Pioneer Surgical Technology, Inc. Intervertebral implant
CN111200976B (en) 2017-10-09 2023-07-07 微仙美国有限公司 Radioactive liquid embolism
US11123375B2 (en) 2017-10-18 2021-09-21 Lifecell Corporation Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products
AU2018351051A1 (en) 2017-10-18 2020-03-19 Lifecell Corporation Adipose tissue products and methods of production
US11246994B2 (en) 2017-10-19 2022-02-15 Lifecell Corporation Methods for introduction of flowable acellular tissue matrix products into a hand
JP7463273B2 (en) 2017-10-19 2024-04-08 ライフセル コーポレーション Flowable acellular tissue matrix products and methods of manufacture - Patents.com
WO2019089567A1 (en) 2017-10-30 2019-05-09 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
US11376345B2 (en) 2017-11-23 2022-07-05 Sentigel Ab Hydrogel composition and its uses
EP4321182A2 (en) 2018-05-09 2024-02-14 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions
CN109224123B (en) * 2018-10-11 2021-04-09 成都迪康中科生物医学材料有限公司 Nano-hydroxyapatite composite material with tumor inhibition effect and preparation method thereof
EP3653171A1 (en) 2018-11-16 2020-05-20 Sofradim Production Implants suitable for soft tissue repair
WO2020120805A2 (en) 2018-12-14 2020-06-18 Institut Químic De Sarrià Cets Fundació Privada Heterogeneous scaffolds and methods of functionalising surfaces
US11090412B2 (en) 2018-12-21 2021-08-17 Zavation Medical Products Llc Bone repair composition and kit
WO2020243497A1 (en) 2019-05-30 2020-12-03 Lifecell Corporation Biologic breast implant
WO2020252230A1 (en) * 2019-06-13 2020-12-17 The Regents Of The University Of California Osteoinductive modified gelatin hydrogels and methods of making and using the same
US11446084B2 (en) 2019-07-12 2022-09-20 Neuralink Corp. Laser drilling of pia mater
CN110787325A (en) * 2019-09-21 2020-02-14 常州百瑞吉生物医药有限公司 Disulfide bond cross-linked hyaluronic acid gel for preventing abdominal (pelvic) cavity postoperative tissue adhesion and preparation method thereof
KR102099846B1 (en) * 2019-09-26 2020-04-14 (주)리젠바이오참 Method for preparing biodegradable polymer support coated with dextran and protein complex
CN111171332B (en) * 2019-12-31 2021-09-28 广州贝奥吉因生物科技股份有限公司 Nitric oxide releasing hydrogel and preparation method thereof
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
CN112140669A (en) * 2020-09-22 2020-12-29 苏州经结纬面料科技有限公司 Outdoor sports fabric and preparation process thereof
CN114644739B (en) * 2020-12-18 2023-08-22 武汉理工大学 High-adhesiveness hydrogel, preparation method and application
CN112807483B (en) * 2021-02-03 2022-10-21 中国药科大学 Anti-inflammatory, antibacterial and hemostatic double-network hydrogel and preparation method and application thereof
CN115068666B (en) * 2021-03-10 2023-12-26 广东粤港澳大湾区国家纳米科技创新研究院 Anti-adhesion hemostatic hydrogel and preparation method and application thereof
CN113101264B (en) * 2021-04-08 2022-05-03 西南交通大学 Hydrogel with ROS response and preparation method and application thereof
CN113425893A (en) * 2021-07-26 2021-09-24 郑州大学 Preparation method and application of drug-loaded hydrogel
CN113941026A (en) * 2021-10-25 2022-01-18 浙江中医药大学 Bioactive glass-coated chitosan cellulose derivative-based injectable hydrogel dressing and preparation method thereof
CN114767922B (en) * 2022-03-15 2023-09-12 青岛大学 Hyaluronic acid hydrogel carrying probiotics and preparation method and application thereof
CN115844927B (en) * 2023-03-02 2023-05-12 深圳汉盛再生医学科技有限公司 Application of stem cells in preparation of preparation for treating leukoencephalopathy
CN116036361B (en) * 2023-03-29 2023-06-20 四川大学 Injection hydrogel and preparation method and application thereof

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4618490A (en) 1980-06-06 1986-10-21 Marco Peter T De Method of treatment of animal and human tissues damaged by burns and frank visible gangrene
SU1002356A1 (en) 1980-12-31 1983-03-07 Всесоюзный кардиологический научный центр АМН СССР Process for preparing immobilized fibrinolysin
US4520821A (en) 1982-04-30 1985-06-04 The Regents Of The University Of California Growing of long-term biological tissue correction structures in vivo
GB2148901A (en) * 1983-10-04 1985-06-05 Johnson & Johnson Protein/polysaccharide complexes
GB8328074D0 (en) 1983-10-20 1983-11-23 Geistlich Soehne Ag Chemical compositions
DE3414924A1 (en) * 1984-04-19 1985-10-31 Klaus Dr.med. Dr.med.habil. 8000 München Draenert COATED ANCHORAGE PART FOR IMPLANTS
US4563350A (en) 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US4863856A (en) 1985-04-04 1989-09-05 Verax Corporation Weighted collagen microsponge for immobilizing bioactive materials
US4997753A (en) 1985-04-04 1991-03-05 Verax Corporation Weighted collagen microsponge for immobilizing bioactive material
US5100783A (en) 1985-05-10 1992-03-31 Verax Corporation Weighted microsponge for immobilizing bioactive material
US4895724A (en) 1985-06-07 1990-01-23 Pfizer Inc. Chitosan compositions for controlled and prolonged release of macromolecules
US4902295A (en) 1985-08-26 1990-02-20 Hana Biologics, Inc. Transplantable artificial tissue
AU589438B2 (en) 1985-08-26 1989-10-12 Hana Biologics, Inc. Transplantable artificial tissue and process
JPS62246371A (en) 1986-04-19 1987-10-27 株式会社　高研 Artificial skin and its production
US5457093A (en) 1987-09-18 1995-10-10 Ethicon, Inc. Gel formulations containing growth factors
US5705485A (en) 1987-09-18 1998-01-06 Ethicon, Inc. Gel formulations containing growth factors
US5263983A (en) 1988-03-09 1993-11-23 Terumo Kabushiki Kaisha Medical material and prosthetic skin in which cells can invade
US5350583A (en) 1988-03-09 1994-09-27 Terumo Kabushiki Kaisha Cell-penetrable medical material and artificial skin
US4950483A (en) 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
US5800541A (en) 1988-11-21 1998-09-01 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
US5306500A (en) * 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US4957902A (en) 1988-12-20 1990-09-18 Board Of Regents, The University Of Texas System Peptide inhibitors of wound contraction
US5290558A (en) 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5073373A (en) 1989-09-21 1991-12-17 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5466609A (en) 1990-10-31 1995-11-14 Coulter Corporation Biodegradable gelatin-aminodextran particle coatings of and processes for making same
US5099012A (en) 1990-12-11 1992-03-24 Eastman Kodak Company Chroman-2-carboxamide conjugates and their use for treatment of reperfusion injury
CS277533B6 (en) 1990-12-29 1993-03-17 Krajicek Milan Fixed osteaosynthesis appliance
DK0585368T3 (en) 1991-04-25 1998-03-16 Univ Brown Res Found Implantable biocompatible immuno-insulating vehicle for delivery of selected therapeutic products
US5605938A (en) 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5591709A (en) 1991-08-30 1997-01-07 Life Medical Sciences, Inc. Compositions and methods for treating wounds
EP0544259A1 (en) 1991-11-27 1993-06-02 Lignyte Co., Ltd. Water insoluble biocompatible hyaluronic and polyion complex and method of making the same
US5824331A (en) 1992-02-24 1998-10-20 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
EP0587840B1 (en) 1992-02-24 1999-12-15 Encelle, Inc. Bioartificial endocrine device
US6352707B1 (en) 1992-02-24 2002-03-05 Anton-Lewis Usala Transplant encapsulation in a hydrogel matrix to obscure immune recognition
US5834005A (en) 1992-02-24 1998-11-10 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5830492A (en) 1992-02-24 1998-11-03 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5514379A (en) * 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
CA2176927C (en) 1993-11-17 2010-03-23 Seang H. Yiv Transparent liquid for encapsulated drug delivery
US5569468A (en) 1994-02-17 1996-10-29 Modi; Pankaj Vaccine delivery system for immunization, using biodegradable polymer microspheres
DE69527141T2 (en) 1994-04-29 2002-11-07 Scimed Life Systems Inc STENT WITH COLLAGEN
US5783214A (en) 1994-06-13 1998-07-21 Buford Biomedical, Inc. Bio-erodible matrix for the controlled release of medicinals
SE503711C2 (en) 1994-12-14 1996-08-12 Medicarb Ab Multistage procedure for coating an intraocular lens
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5733337A (en) 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
US5830879A (en) * 1995-10-02 1998-11-03 St. Elizabeth's Medical Center Of Boston, Inc. Treatment of vascular injury using vascular endothelial growth factor
US6833408B2 (en) * 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
JP2000511512A (en) * 1996-05-03 2000-09-05 イノジェネティックス・ナムローゼ・フェンノートシャップ Novel pharmaceuticals containing gelatin crosslinked with oxidized polysaccharide
US5718012A (en) 1996-05-28 1998-02-17 Organogenesis, Inc. Method of strength enhancement of collagen constructs
FR2754268B1 (en) * 1996-10-07 1998-12-24 Dev Des Utilisations Du Collag ADHESIVE COMPOSITION BASED ON MACROMOLECULAR POLYALDEHYDE AND METHOD FOR CROSSLINKING COLLAGEN OR GELATIN
US5756715A (en) 1996-11-08 1998-05-26 Abbott Laboratories Process for making crystalline iron dextran
US6011008A (en) 1997-01-08 2000-01-04 Yissum Research Developement Company Of The Hebrew University Of Jerusalem Conjugates of biologically active substances
US5866165A (en) 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
US6582472B2 (en) * 1997-02-26 2003-06-24 Applied Medical Resources Corporation Kinetic stent
US5972332A (en) 1997-04-16 1999-10-26 The Regents Of The University Of Michigan Wound treatment with keratinocytes on a solid support enclosed in a porous material
US5993844A (en) 1997-05-08 1999-11-30 Organogenesis, Inc. Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
WO1998055161A1 (en) 1997-06-03 1998-12-10 Innogenetics N.V. New medicaments based on polymers composed of methacrylamide-modified gelatin
US6077916A (en) 1997-06-04 2000-06-20 The Penn State Research Foundation Biodegradable mixtures of polyphoshazene and other polymers
CN1161127C (en) 1997-07-03 2004-08-11 奥奎斯特公司 Cross-linked polysaccharide drug carrier
AU8681098A (en) * 1997-08-01 1999-03-08 Massachusetts Institute Of Technology Three-dimensional polymer matrices
US5922339A (en) 1998-01-27 1999-07-13 Usala; Anton-Lewis Compositions and methods for biocompatible implants
US6378527B1 (en) * 1998-04-08 2002-04-30 Chondros, Inc. Cell-culture and polymer constructs
GB9902652D0 (en) 1999-02-05 1999-03-31 Fermentech Med Ltd Process
US6299448B1 (en) * 1999-02-17 2001-10-09 Ivanka J. Zdrahala Surgical implant system for restoration and repair of body function
FR2794649B1 (en) * 1999-06-11 2003-04-11 Solutions BIOMATERIAL BASED ON AN INSOLUBILIZED DEXTRAN DERIVATIVE AND A GROWTH FACTOR, METHOD FOR PREPARING SAME AND ITS APPLICATIONS
EP1142596A1 (en) 2000-04-03 2001-10-10 Universiteit Gent Compositions of crosslinkable prepolymers for use in therapeutically active biodegradable implants
US6682760B2 (en) 2000-04-18 2004-01-27 Colbar R&D Ltd. Cross-linked collagen matrices and methods for their preparation
JP2001316285A (en) * 2000-05-01 2001-11-13 Yasuhiko Tabata Material for regeneration of tissue organ composed of cell and cell growth factor
JP2004535836A (en) * 2000-11-14 2004-12-02 エヌ．ブイ．アール． ラブズ インコーポレイテッド Crosslinked hyaluronic acid-laminin gels and their use in cell culture and medical implants
JP4489437B2 (en) * 2002-02-21 2010-06-23 エンセル，インコーポレイテッド Immobilized bioactive hydrogel matrix as a surface coating

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