CA2476929A1 - Tissue repair matrix - Google Patents
Tissue repair matrix Download PDFInfo
- Publication number
- CA2476929A1 CA2476929A1 CA002476929A CA2476929A CA2476929A1 CA 2476929 A1 CA2476929 A1 CA 2476929A1 CA 002476929 A CA002476929 A CA 002476929A CA 2476929 A CA2476929 A CA 2476929A CA 2476929 A1 CA2476929 A1 CA 2476929A1
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- CA
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- Prior art keywords
- matrix
- collagen
- binder
- soluble
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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Abstract
A porous three-dimensional tissue repair matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium phosphate immobilized in the matrix.
Claims (26)
1. An implantable porous, biodegradable, three-dimensionally fixed matrix having shape memory comprising a network of water-insoluble mineralized biopolymer fibers, a drug and a water-soluble binder which is rendered insoluble by cross-linking.
2. An implantable, porous, biodegradable, three-dimensionally fixed matrix for bone growth having shape memory which maintains its porosity for a period greater than about fourteen days after implant into a physiological environment in which said bone growth is required, comprising insoluble mineralized biopolymer fibers, a drug and a water-soluble binder which is rendered insoluble by cross-linking.
3. A matrix according to claim 1 or 2 wherein said matrix is compressible from its initial size, shape and porosity and returns from a compressed state without substantial loss of said fibers or binder.
4. A matrix according to claim 1 or 2 wherein said drug comprises an antibiotic.
5. A matrix according to claim 1 or 2 further comprising a growth factor.
6. A matrix according to claim 1 or 2 further comprising marrow.
7. A matrix according to claims 1 or 2 wherein said binder is selected from the group consisting of soluble collagen, gelatin, polylactic acid, polyglycolic acid, copolymers of lactic and glycolic acid, polycaprolactone, carboxymethylcellulose, cellulose esters, dextrose, dextran, chitosan, hyaluronic acid, ficol, chondroitin sulfate, polyvinyl alcohol, polyacrylic acid, polypropylene glycol, polyethylene glycol, water soluble polyacrylates and water soluble polymethacrylates.
8. A matrix according to claim 1 or 2 wherein said biopolymer comprises fibrillar collagen.
9. A matrix according to claim 1 or 2 wherein said mineral comprises hydroxyapatite.
10. A matrix according to claim 2 wherein said mineral is released into said physiological environment during replacement with bone in a time-release profile which maintains said porosity for said period of time.
11. A matrix according to claim 1 or 2 wherein said mineralized biopolymer fibers are in the form of mineralized collagen containing about 30-95% by weight of collagen.
12. A matrix according to claim 1 or 2 further comprising autogenous bone.
13. A method of repairing fibrous tissue or cartilage comprising the step of introducing to a target site of repair a composition comprising are effective amount of a porous, biodegradable, three-dimensionally fixed matrix having shape memory comprising insoluble mineralized biopolymer fibers and a water-soluble binder which is rendered insoluble by cross-linking, sufficient to promote new fibrous tissue or cartilage formation.
14. A method of repairing fibrous tissue, cartilage or bone comprising the steps of:
(a) introducing a delivery vehicle to a target site of repair, said vehicle containing a porous, biodegradable, three-dimensionally fixed matrix having shape memory comprising insoluble mineralized biopolymer fibers and a water-soluble binder which is rendered insoluble by cross-linking in a compressed state relative to the initial size, shape acid porosity of said matrix; and (b) releasing said matrix from said delivery vehicle whereby said matrix returns to said initial size, shape and porosity.
(a) introducing a delivery vehicle to a target site of repair, said vehicle containing a porous, biodegradable, three-dimensionally fixed matrix having shape memory comprising insoluble mineralized biopolymer fibers and a water-soluble binder which is rendered insoluble by cross-linking in a compressed state relative to the initial size, shape acid porosity of said matrix; and (b) releasing said matrix from said delivery vehicle whereby said matrix returns to said initial size, shape and porosity.
15. A method according to claim 13 or 14 wherein said matrix returns to said initial size, shape and porosity without loss of a substantial amount of said fibers and binder.
16. A method according to claims 13 or 14 wherein said matrix further comprising an additive.
17. A method according to claim 16 wherein said additive comprises a drug.
18. A method according to claim 17 wherein said drug comprises an antibiotic.
19. A method according to claim 16 wherein said additive comprises a growth factor.
20. A method according to claim 13 or 14 wherein said matrix further comprises marrow.
21. A method according to claim 13 or 14 wherein said binder is selected from the group consisting of soluble collagen, gelatin, polylactic acid, polyglycolic acid, copolymers of lactic and glycolic acid, polycaprolactone, carboxymethylcellulose, cellulose esters, dextrose, dextran, chitosan, hyaluronic acid, ficol, chondroitin sulfate, polyvinyl alcohol, polyacrylic acid, polypropylene glycol, polyethylene glycol, water soluble polyacrylates and water soluble polymethacrylates.
22. A method according to claim 13 or 14 wherein said biopolymer comprises fibrillar collagen.
23. A method according to claim 13 or 14 wherein the mineral of said mineralized biopolymer fibers comprises hydroxyapatite.
24. A method according to claim 13 or 14 wherein said matrix comprises collagen and immobilized calcium phosphate in the form of mineralized collagen containing about 30-95% by weight of collagen.
25. A method according to claim 13 or 14 wherein said matrix further comprises autogenous bone.
26. A method according to claim 21 wherein said binder comprises soluble collagen.
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US552395P | 1995-10-16 | 1995-10-16 | |
US08/633,554 US5776193A (en) | 1995-10-16 | 1996-04-17 | Bone grafting matrix |
US10/086,225 US6764517B2 (en) | 1995-10-16 | 2002-02-22 | Tissue repair matrix |
US10/086,225 | 2002-02-22 | ||
PCT/US2003/005426 WO2003071991A1 (en) | 1995-10-16 | 2003-02-21 | Tissue repair matrix |
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CA2476929A1 true CA2476929A1 (en) | 2003-09-04 |
CA2476929C CA2476929C (en) | 2011-06-21 |
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CA002232986A Expired - Fee Related CA2232986C (en) | 1995-10-16 | 1996-10-15 | Bone grafting matrix |
CA2476929A Expired - Fee Related CA2476929C (en) | 1995-10-16 | 2003-02-21 | Tissue repair matrix |
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CA002232986A Expired - Fee Related CA2232986C (en) | 1995-10-16 | 1996-10-15 | Bone grafting matrix |
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EP (2) | EP0855884B1 (en) |
JP (2) | JP4275732B2 (en) |
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DK (1) | DK0855884T3 (en) |
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NZ (2) | NZ321756A (en) |
PT (1) | PT855884E (en) |
WO (2) | WO1997014376A1 (en) |
Families Citing this family (255)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6132674A (en) * | 1995-10-12 | 2000-10-17 | Bristol-Myers Squibb Company | Method of making an orthopaedic implant having a porous surface |
US5776193A (en) * | 1995-10-16 | 1998-07-07 | Orquest, Inc. | Bone grafting matrix |
IT1282207B1 (en) * | 1995-11-20 | 1998-03-16 | Fidia Advanced Biopolymers Srl | HUMAN BONE MARROW STEM CELL CULTURE SYSTEMS IN THREE-DIMENSIONAL MATRIXES CONSISTING OF HYALURONIC ACID ESTERS |
US6221854B1 (en) * | 1996-03-05 | 2001-04-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
US20110207666A1 (en) * | 1996-03-05 | 2011-08-25 | Depuy Spine, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
US20020098222A1 (en) * | 1997-03-13 | 2002-07-25 | John F. Wironen | Bone paste |
EP1014897B1 (en) | 1997-05-30 | 2008-10-29 | Osteobiologics, Inc. | Fiber-reinforced, porous, biodegradable implant device |
US7524335B2 (en) * | 1997-05-30 | 2009-04-28 | Smith & Nephew, Inc. | Fiber-reinforced, porous, biodegradable implant device |
DE19726412A1 (en) * | 1997-06-21 | 1998-12-24 | Merck Patent Gmbh | Implant material with a carrier-drug combination |
US6241771B1 (en) * | 1997-08-13 | 2001-06-05 | Cambridge Scientific, Inc. | Resorbable interbody spinal fusion devices |
US6977095B1 (en) * | 1997-10-01 | 2005-12-20 | Wright Medical Technology Inc. | Process for producing rigid reticulated articles |
US6296667B1 (en) * | 1997-10-01 | 2001-10-02 | Phillips-Origen Ceramic Technology, Llc | Bone substitutes |
US20040081704A1 (en) | 1998-02-13 | 2004-04-29 | Centerpulse Biologics Inc. | Implantable putty material |
US20030147860A1 (en) * | 2002-02-07 | 2003-08-07 | Marchosky J. Alexander | Compositions and methods for forming and strengthening bone |
DE19855890A1 (en) * | 1998-12-03 | 2000-06-08 | Nerlich Michael | Porous composite matrix, its production and use |
US6224629B1 (en) * | 1998-12-09 | 2001-05-01 | Purzer Pharmaceuticals Co. Ltd. | Bone substitute composition and process of preparation thereof |
IT1302534B1 (en) * | 1998-12-21 | 2000-09-05 | Fidia Advanced Biopolymers Srl | INJECTABLE, BIOCOMPATIBLE AND BIODEGRADABLE COMPOSITIONS INCLUDING AT LEAST A DERIVATIVE OF HYALURONIC ACID, CHONDROGENIC CELLS, FOR |
DE19962090B4 (en) * | 1998-12-22 | 2014-07-17 | Karl Weis | Process for the production of moldings |
US6383519B1 (en) * | 1999-01-26 | 2002-05-07 | Vita Special Purpose Corporation | Inorganic shaped bodies and methods for their production and use |
WO2000045871A1 (en) | 1999-02-04 | 2000-08-10 | Sdgi Holdings, Inc. | Highly-mineralized osteogenic sponge compositions, and uses thereof |
CA2362046A1 (en) * | 1999-02-04 | 2000-08-10 | Sdgi Holdings, Inc. | Osteogenic paste compositions and uses thereof |
JP4472804B2 (en) * | 1999-05-18 | 2010-06-02 | 学校法人松本歯科大学 | Bone filler and method for producing the same |
WO2001000792A1 (en) | 1999-06-29 | 2001-01-04 | Marchosky J Alexander | Compositions and methods for forming and strengthening bone |
NZ516738A (en) * | 1999-07-20 | 2004-01-30 | Univ Southern California | Identification of pluripotent pre-mesenchymal, pre-hematopoietic progenitor cells expressing a unique molecular marker |
US6458162B1 (en) * | 1999-08-13 | 2002-10-01 | Vita Special Purpose Corporation | Composite shaped bodies and methods for their production and use |
US6162258A (en) * | 1999-08-25 | 2000-12-19 | Osteotech, Inc. | Lyophilized monolithic bone implant and method for treating bone |
DE19956503A1 (en) * | 1999-11-24 | 2001-06-21 | Universitaetsklinikum Freiburg | Sprayable bone replacement material |
KR100331608B1 (en) * | 1999-11-25 | 2002-04-09 | 김정근 | Process for manufacturing of bone graft materials using animal bones |
WO2001082828A2 (en) * | 2000-04-28 | 2001-11-08 | Anthony Atala | Tissue engineered testicular prosthesis and use thereof |
CA2410637C (en) * | 2000-05-31 | 2007-04-10 | Mnemoscience Gmbh | Shape memory polymers seeded with dissociated cells for tissue engineering |
DE10028975B4 (en) * | 2000-06-16 | 2005-06-30 | Henkel Kgaa | Compositions for the treatment of tooth and / or bone tissue |
DE10029520A1 (en) * | 2000-06-21 | 2002-01-17 | Merck Patent Gmbh | Coating for metallic implant materials |
US7726319B1 (en) | 2000-08-24 | 2010-06-01 | Osteotech, Inc. | Method for removal of water associated with bone while diminishing the dimensional changes associated with lyophilization |
EP1335686B1 (en) * | 2000-10-24 | 2008-12-17 | Warsaw Orthopedic, Inc. | Spinal fusion devices |
EP1337266A4 (en) * | 2000-10-31 | 2006-11-02 | Depuy Spine Inc | Mineralized collagen-polysaccharide matrix for bone and cartilage repair |
US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
AU2002246785A1 (en) * | 2000-12-28 | 2002-08-06 | The Board Of Regents Of The University Of Nebraska | Electrolytic deposition of coatings for prosthetic metals and alloys |
US6558709B2 (en) * | 2001-01-05 | 2003-05-06 | Howmedica Osteonics Corp. | Calcium phosphate composition and method of preparing same |
US9080146B2 (en) | 2001-01-11 | 2015-07-14 | Celonova Biosciences, Inc. | Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface |
US7700819B2 (en) * | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
US20020115742A1 (en) * | 2001-02-22 | 2002-08-22 | Trieu Hai H. | Bioactive nanocomposites and methods for their use |
JP4790917B2 (en) * | 2001-02-23 | 2011-10-12 | 独立行政法人科学技術振興機構 | Artificial vertebral body |
US6949251B2 (en) * | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
GB0115320D0 (en) * | 2001-06-22 | 2001-08-15 | Univ Nottingham | Matrix |
IL144446A0 (en) * | 2001-07-19 | 2002-05-23 | Prochon Biotech Ltd | Plasma protein matrices and methods for their preparation |
JP2003180820A (en) * | 2001-10-09 | 2003-07-02 | Techno Network Shikoku Co Ltd | Biological material, drug, food, medical instrument, cell culture instrument and process of producing tissue- inducible material |
JP4403268B2 (en) * | 2001-10-21 | 2010-01-27 | 独立行政法人産業技術総合研究所 | Method for producing calcium phosphate porous sintered body and method for producing artificial bone using the same |
JP2003169845A (en) * | 2001-12-07 | 2003-06-17 | Japan Science & Technology Corp | Sponge-like porous apatite-collagen composite, sponge-like superporous apatite-collagen composite and method of manufacturing the same |
DE60335246D1 (en) * | 2002-02-22 | 2011-01-20 | Depuy Spine Inc | GEWEBSREPARATURMATRIX |
TW200400062A (en) * | 2002-04-03 | 2004-01-01 | Mathys Medizinaltechnik Ag | Kneadable, pliable bone replacement material |
US7776600B2 (en) | 2002-04-18 | 2010-08-17 | Carnegie Mellon University | Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids |
US7247288B2 (en) * | 2002-04-18 | 2007-07-24 | Carnegie Mellon University | Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids |
JP2005528144A (en) | 2002-04-29 | 2005-09-22 | バイオメット ドイチュラント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Structural complex as a matrix for bone tissue engineering |
US7163965B2 (en) * | 2002-05-01 | 2007-01-16 | Japan Science And Technology Agency | Process for producing porous composite materials |
US20030225347A1 (en) * | 2002-06-03 | 2003-12-04 | Argenta Louis C. | Directed tissue growth employing reduced pressure |
US7166133B2 (en) | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
US7846141B2 (en) | 2002-09-03 | 2010-12-07 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
GB0224986D0 (en) | 2002-10-28 | 2002-12-04 | Smith & Nephew | Apparatus |
CN100372579C (en) * | 2002-11-06 | 2008-03-05 | 独立行政法人物质·材料研究机构 | Cross-linked apatite/collagen porous body containing self-organized apatite/collagen composite and its production method |
ITMI20030186A1 (en) * | 2003-02-05 | 2004-08-06 | Consiglio Nazionale Ricerche | ARTIFICIAL BONE TISSUE SYNTHESIS PROCEDURE, |
GB0307011D0 (en) * | 2003-03-27 | 2003-04-30 | Regentec Ltd | Porous matrix |
JP4680771B2 (en) * | 2003-05-26 | 2011-05-11 | Hoya株式会社 | Calcium phosphate-containing composite porous body and method for producing the same |
WO2005000483A1 (en) * | 2003-06-06 | 2005-01-06 | Tufts University | Method for forming inorganic coatings |
DE10328892A1 (en) * | 2003-06-26 | 2005-05-12 | Curasan Ag | Bone building agent and manufacturing process |
US7955616B2 (en) * | 2003-09-23 | 2011-06-07 | Orthocon, Inc. | Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects |
US7687138B2 (en) * | 2003-10-27 | 2010-03-30 | Hoya Corporation | Porous calcium phosphate ceramic and method for producing same |
JP4671596B2 (en) * | 2003-11-26 | 2011-04-20 | 京セラ株式会社 | Porous bone repair material and method for producing the same |
US20070231788A1 (en) * | 2003-12-31 | 2007-10-04 | Keyvan Behnam | Method for In Vitro Assay of Demineralized Bone Matrix |
WO2005065396A2 (en) * | 2003-12-31 | 2005-07-21 | Osteotech, Inc. | Improved bone matrix compositions and methods |
US7189263B2 (en) * | 2004-02-03 | 2007-03-13 | Vita Special Purpose Corporation | Biocompatible bone graft material |
JP4643166B2 (en) * | 2004-03-30 | 2011-03-02 | 独立行政法人物質・材料研究機構 | Method for controlling average pore diameter of porous material containing apatite / collagen composite fiber |
US20070190101A1 (en) * | 2004-03-31 | 2007-08-16 | Chunlin Yang | Flowable bone grafts |
US8062272B2 (en) | 2004-05-21 | 2011-11-22 | Bluesky Medical Group Incorporated | Flexible reduced pressure treatment appliance |
US7909805B2 (en) | 2004-04-05 | 2011-03-22 | Bluesky Medical Group Incorporated | Flexible reduced pressure treatment appliance |
US10058642B2 (en) | 2004-04-05 | 2018-08-28 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
GB0409446D0 (en) | 2004-04-28 | 2004-06-02 | Smith & Nephew | Apparatus |
JP2007537007A (en) | 2004-05-12 | 2007-12-20 | マサチューセッツ インスティテュート オブ テクノロジー | Manufacturing methods such as three-dimensional printing including solvent vapor film formation |
US9220595B2 (en) | 2004-06-23 | 2015-12-29 | Orthovita, Inc. | Shapeable bone graft substitute and instruments for delivery thereof |
WO2006031196A1 (en) * | 2004-09-14 | 2006-03-23 | Agency For Science, Technology And Research | Porous biomaterial-filler composite and a method for making the same |
US7722895B1 (en) * | 2004-09-20 | 2010-05-25 | Warsaw Orthopedic, Inc. | Osteogenic implants with combined implant materials, and materials and methods for same |
US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
US9107850B2 (en) | 2004-10-25 | 2015-08-18 | Celonova Biosciences, Inc. | Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
US20210299056A9 (en) | 2004-10-25 | 2021-09-30 | Varian Medical Systems, Inc. | Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods |
US9114162B2 (en) | 2004-10-25 | 2015-08-25 | Celonova Biosciences, Inc. | Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same |
AU2005298344B2 (en) | 2004-10-25 | 2011-02-10 | Varian Medical Systems, Inc. | Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
WO2006046414A1 (en) * | 2004-10-28 | 2006-05-04 | National Institute For Materials Science | Process for producing porous object comprising apatite/collagen composite fiber |
WO2006056391A2 (en) * | 2004-11-23 | 2006-06-01 | Ossacur Ag | Bioresorbable, surface-mineralised material for filling osseous defects |
DE102005016443A1 (en) * | 2004-11-23 | 2006-05-24 | Ossacur Ag | Bioabsorbable and mineralized material, useful for filling of bone defects, comprises a collagen matrix from aggregated collagen chains, where only the surface of the aggregated collagen chain is mineralized |
WO2006062518A2 (en) | 2004-12-08 | 2006-06-15 | Interpore Spine Ltd. | Continuous phase composite for musculoskeletal repair |
US20070038303A1 (en) * | 2006-08-15 | 2007-02-15 | Ebi, L.P. | Foot/ankle implant and associated method |
US8535357B2 (en) | 2004-12-09 | 2013-09-17 | Biomet Sports Medicine, Llc | Continuous phase compositions for ACL repair |
DE102005034420A1 (en) * | 2004-12-23 | 2006-07-06 | Ossacur Ag | Gel-like material for filling bone and / or cartilage defects |
US7621963B2 (en) * | 2005-04-13 | 2009-11-24 | Ebi, Llc | Composite bone graft material |
US20060233849A1 (en) * | 2005-04-13 | 2006-10-19 | Simon Bruce J | Composite bone graft material |
US7740794B1 (en) | 2005-04-18 | 2010-06-22 | Biomet Sports Medicine, Llc | Methods of making a polymer and ceramic composite |
US7857853B2 (en) * | 2005-04-29 | 2010-12-28 | Sdgi Holdings, Inc | Synthetic loadbearing collagen-mineral composites useful for spinal implants, and methods of manufacture |
US8506646B2 (en) * | 2005-04-29 | 2013-08-13 | Warsaw Orthopedic, Inc. | Multi-purpose medical implant devices |
US20060251628A1 (en) * | 2005-05-06 | 2006-11-09 | Mohamed Attawia | Defatted, dewatered bone marrow |
US8518436B2 (en) * | 2005-05-16 | 2013-08-27 | Purdue Research Foundation | Engineered extracellular matrices |
GB0517499D0 (en) | 2005-08-26 | 2005-10-05 | West Hertfordshire Hospitals N | Surgical scaffold |
EP1937701A4 (en) * | 2005-09-02 | 2009-09-16 | Colbar Lifescience Ltd | Cross-linked polysaccharide and protein matrices and methods for their preparation |
US8921109B2 (en) | 2005-09-19 | 2014-12-30 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
US9005646B2 (en) | 2005-10-12 | 2015-04-14 | Lifenet Health | Compositions for repair of defects in tissues, and methods of making the same |
US9132208B2 (en) * | 2008-08-07 | 2015-09-15 | Lifenet Health | Composition for a tissue repair implant and methods of making the same |
US8911759B2 (en) * | 2005-11-01 | 2014-12-16 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
US20120114763A1 (en) * | 2005-11-14 | 2012-05-10 | Genoss Ltd | Method for Producing Collagen/Apatite Composite Membrane for Guided Bone Regeneration |
US20100040668A1 (en) * | 2006-01-12 | 2010-02-18 | Rutgers, The State University Of New Jersey | Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof |
US8287914B2 (en) * | 2006-01-12 | 2012-10-16 | Rutgers, The State University Of New Jersey | Biomimetic hydroxyapatite synthesis |
WO2007084725A2 (en) | 2006-01-19 | 2007-07-26 | Osteotech, Inc. | Injectable and moldable bone substitute materials |
US20070173949A1 (en) * | 2006-01-25 | 2007-07-26 | Sharps Lewis S | Bonding system for orthopedic implants |
US7939092B2 (en) * | 2006-02-01 | 2011-05-10 | Warsaw Orthopedic, Inc. | Cohesive osteogenic putty and materials therefor |
DE102006011211A1 (en) * | 2006-03-02 | 2007-09-06 | Ossacur Ag | Material for the treatment of bone and / or cartilage defects |
WO2007117499A2 (en) * | 2006-04-05 | 2007-10-18 | University Of Nebraska | Bioresorbable polymer reconstituted bone and methods of formation thereof |
US20070269476A1 (en) | 2006-05-16 | 2007-11-22 | Voytik-Harbin Sherry L | Engineered extracellular matrices control stem cell behavior |
US8303967B2 (en) | 2006-06-29 | 2012-11-06 | Orthovita, Inc. | Bioactive bone graft substitute |
JP4997452B2 (en) | 2006-08-22 | 2012-08-08 | 三菱電機株式会社 | Laser processing apparatus, bone joining method, implant material, implant material manufacturing method, and implant material manufacturing apparatus |
JP2008061897A (en) * | 2006-09-08 | 2008-03-21 | Saga Univ | Living body implant |
US8084055B2 (en) * | 2006-09-21 | 2011-12-27 | Purdue Research Foundation | Collagen preparation and method of isolation |
DE102006048833A1 (en) * | 2006-10-16 | 2008-04-17 | Universität Rostock | Combination for preparing medicine product for treatment of osteoporosis, prophylaxis or bone fractures, or for anchorage of implants, comprises calcium-containing substance and cross linking agent |
US8106008B2 (en) * | 2006-11-03 | 2012-01-31 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
US7931651B2 (en) | 2006-11-17 | 2011-04-26 | Wake Lake University Health Sciences | External fixation assembly and method of use |
US7544212B2 (en) * | 2006-12-08 | 2009-06-09 | Collagen Matrix, Inc. | Bone implant composite |
US7381224B1 (en) | 2006-12-08 | 2008-06-03 | Collagen Matrix, Inc. | Bone implant composite |
AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
US8048857B2 (en) * | 2006-12-19 | 2011-11-01 | Warsaw Orthopedic, Inc. | Flowable carrier compositions and methods of use |
US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
US8377016B2 (en) | 2007-01-10 | 2013-02-19 | Wake Forest University Health Sciences | Apparatus and method for wound treatment employing periodic sub-atmospheric pressure |
EP1964583A1 (en) | 2007-02-09 | 2008-09-03 | Royal College of Surgeons in Ireland | Process for producing a collagen/hydroxyapatite composite scaffold |
US8431148B2 (en) * | 2007-03-08 | 2013-04-30 | Warsaw Orthopedic, Inc. | Bone void filler |
US9554920B2 (en) | 2007-06-15 | 2017-01-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
WO2008157495A2 (en) * | 2007-06-15 | 2008-12-24 | Osteotech, Inc. | Bone matrix compositions and methods |
WO2008157492A2 (en) | 2007-06-15 | 2008-12-24 | Osteotech, Inc. | Osteoinductive demineralized cancellous bone |
US8642061B2 (en) | 2007-06-15 | 2014-02-04 | Warsaw Orthopedic, Inc. | Method of treating bone tissue |
US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
ITMI20071298A1 (en) * | 2007-06-29 | 2008-12-30 | Univ Bologna Alma Mater | POROUS COMPOSITE MATERIAL, RELATED PREPARATION PROCESS AND ITS USE FOR THE DEVELOPMENT OF DEVICES FOR TISSUE ENGINEERING |
US9492278B2 (en) * | 2007-07-10 | 2016-11-15 | Warsaw Orthopedic, Inc. | Delivery system |
JP5323832B2 (en) | 2007-08-07 | 2013-10-23 | アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー | Protein preparation containing GDF-5 in acidic aqueous solution |
US20110076316A1 (en) * | 2007-10-08 | 2011-03-31 | Sureshan Sivananthan | Scalable matrix for the in vivo cultivation of bone and cartilage |
BRPI0817544A2 (en) | 2007-10-10 | 2017-05-02 | Univ Wake Forest Health Sciences | apparatus for treating damaged spinal cord tissue |
ES2446544T3 (en) | 2007-10-19 | 2014-03-10 | Warsaw Orthopedic, Inc. | Demineralized bone matrix compositions and methods |
US7998499B2 (en) * | 2007-10-25 | 2011-08-16 | Collagen Matrix, Inc. | Calcium-containing bone implants |
JP2009132601A (en) * | 2007-11-01 | 2009-06-18 | Hoya Corp | Porous body comprising apatite/collagen composite fiber and its production method |
US9149563B2 (en) * | 2007-11-06 | 2015-10-06 | The University Of Connecticut | Calcium phosphate/structural protein composites and method of preparation thereof |
EP2211763A4 (en) * | 2007-11-06 | 2013-02-13 | Univ Connecticut | Ceramic/structural protein composites and method of preparation thereof |
US20090131886A1 (en) | 2007-11-16 | 2009-05-21 | Liu Y King | Steerable vertebroplasty system |
US9510885B2 (en) | 2007-11-16 | 2016-12-06 | Osseon Llc | Steerable and curvable cavity creation system |
US20090131867A1 (en) | 2007-11-16 | 2009-05-21 | Liu Y King | Steerable vertebroplasty system with cavity creation element |
CN101868203B (en) | 2007-11-21 | 2014-10-22 | 史密夫及内修公开有限公司 | Wound dressing |
GB0722820D0 (en) | 2007-11-21 | 2008-01-02 | Smith & Nephew | Vacuum assisted wound dressing |
EP2987510B1 (en) | 2007-11-21 | 2020-10-28 | T.J. Smith & Nephew Limited | Suction device and dressing |
US11253399B2 (en) | 2007-12-06 | 2022-02-22 | Smith & Nephew Plc | Wound filling apparatuses and methods |
GB0723875D0 (en) | 2007-12-06 | 2008-01-16 | Smith & Nephew | Wound management |
WO2009076441A1 (en) | 2007-12-10 | 2009-06-18 | Purdue Research Foundation | Collagen-based matrices with stem cells |
US8267960B2 (en) | 2008-01-09 | 2012-09-18 | Wake Forest University Health Sciences | Device and method for treating central nervous system pathology |
BRPI0906702A2 (en) * | 2008-01-09 | 2015-06-30 | Innovative Health Technologies Llc | Implant granules and methods for bone regeneration and preservation |
WO2009088519A1 (en) * | 2008-01-11 | 2009-07-16 | Rutgers, The State University Of New Jersey | Biomimetic hydroxyapatite composite materials and methods for the preparation thereof |
GB0803564D0 (en) | 2008-02-27 | 2008-04-02 | Smith & Nephew | Fluid collection |
US20140031944A1 (en) * | 2008-03-18 | 2014-01-30 | Yoh Sawatari | Cylindrical graft and method for preparing a recipient site and implanting a cylindrical graft into alveolar jaw bone |
WO2009122902A1 (en) * | 2008-04-02 | 2009-10-08 | Hoya株式会社 | Expandable porous material comprising apatite/collagen complex, and method for production thereof |
CA2720845A1 (en) * | 2008-04-14 | 2009-10-22 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered gdf-5 formulations |
US9616153B2 (en) | 2008-04-17 | 2017-04-11 | Warsaw Orthopedic, Inc. | Rigid bone graft substitute |
US20090263507A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Biological markers and response to treatment for pain, inflammation, neuronal or vascular injury and methods of use |
CA2721507C (en) | 2008-04-18 | 2017-10-03 | Collplant Ltd. | Methods of generating and using procollagen |
US20090263458A1 (en) * | 2008-04-21 | 2009-10-22 | Lasse Daniel Efskind | Material for surgical use in traumatology |
JP5653342B2 (en) * | 2008-04-24 | 2015-01-14 | メドトロニック,インコーポレイテッド | Cold ionizing radiation sterilization |
JP2009268685A (en) * | 2008-05-07 | 2009-11-19 | Hoya Corp | Artificial bone formed by covering it with apatite/collagen complex and its production method |
KR20100007180A (en) * | 2008-07-11 | 2010-01-22 | 세원셀론텍(주) | Method manufacture of bone recovery collagen gel composition |
WO2010009294A1 (en) | 2008-07-18 | 2010-01-21 | Wake Forest University Heath Sciences | Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage |
KR100932945B1 (en) | 2009-01-16 | 2009-12-21 | 원광대학교산학협력단 | Solid scaffold formed with bone powder and fibrin glue |
US9101475B2 (en) | 2009-02-12 | 2015-08-11 | Warsaw Orthopedic, Inc. | Segmented delivery system |
US10806833B1 (en) | 2009-05-11 | 2020-10-20 | Integra Lifesciences Corporation | Adherent resorbable matrix |
US20100298832A1 (en) | 2009-05-20 | 2010-11-25 | Osseon Therapeutics, Inc. | Steerable curvable vertebroplasty drill |
CN102573938B (en) * | 2009-07-23 | 2015-08-05 | 布若贞提克斯骨生物学有限公司 | injectable and mouldable osteoinductive ceramic material |
CA2779109A1 (en) | 2009-10-29 | 2011-05-05 | Prosidyan, Inc. | Dynamic bioactive bone graft material having an engineered porosity |
WO2011059746A1 (en) * | 2009-10-29 | 2011-05-19 | Prosidyan, Inc. | Dynamic bioactive bone graft material and methods for handling |
US8758791B2 (en) | 2010-01-26 | 2014-06-24 | Warsaw Orthopedic, Inc. | Highly compression resistant matrix with porous skeleton |
US9144629B2 (en) | 2010-03-03 | 2015-09-29 | Novabone Products, Llc | Ionically crosslinked materials and methods for production |
WO2015147923A1 (en) | 2010-03-03 | 2015-10-01 | Novabone Products, Llc | Kit for delivering bone grafting materials |
EP2542187B1 (en) * | 2010-03-03 | 2019-11-20 | Novabone Products, LLC | Composition for the regeneration of bony defects |
CN101791438B (en) * | 2010-03-16 | 2013-02-27 | 浙江大学 | Method for preparing bioactive poly(lactic-co-glycolic acid)/collagen/hydroxyapatite composite fiber membrane for bone repair |
CN103002926B (en) | 2010-04-16 | 2015-09-23 | 阿派泰克有限公司 | Biomaterial |
US9061095B2 (en) | 2010-04-27 | 2015-06-23 | Smith & Nephew Plc | Wound dressing and method of use |
BR112012027708B1 (en) | 2010-04-29 | 2021-03-09 | Dfine, Inc | medical device for ablation of tissue within a patient's bone |
US9295695B2 (en) | 2010-04-30 | 2016-03-29 | Skeletal Kinetics, Llc | Temperature-insensitive calcium phosphate cements |
CA3048850A1 (en) | 2010-05-11 | 2011-11-17 | Howmedica Osteonics Corp. | Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods |
US8858577B2 (en) | 2010-05-19 | 2014-10-14 | University Of Utah Research Foundation | Tissue stabilization system |
GB201011173D0 (en) | 2010-07-02 | 2010-08-18 | Smith & Nephew | Provision of wound filler |
US8877220B2 (en) * | 2010-08-05 | 2014-11-04 | Collagen Matrix, Inc. | Self-expandable biopolymer-mineral composite |
WO2012051420A2 (en) | 2010-10-13 | 2012-04-19 | Cibor, Inc. | Synthetic bone grafts constructed from carbon foam materials |
US8926710B2 (en) | 2010-10-25 | 2015-01-06 | Warsaw Orthopedic, Inc. | Osteoinductive bone graft injectable cement |
JP2013542837A (en) | 2010-11-15 | 2013-11-28 | ジンマー オーソバイオロジクス,インコーポレイティド | Bone void filler |
GB201020005D0 (en) | 2010-11-25 | 2011-01-12 | Smith & Nephew | Composition 1-1 |
MX337627B (en) | 2010-11-25 | 2016-03-10 | Smith & Nephew | Composition i-ii and products and uses thereof. |
US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
WO2012099852A1 (en) | 2011-01-17 | 2012-07-26 | Cibor, Inc. | Reinforced carbon fiber/carbon foam intervertebral spine fusion device |
US8852214B2 (en) | 2011-02-04 | 2014-10-07 | University Of Utah Research Foundation | System for tissue fixation to bone |
AU2012259434B2 (en) * | 2011-02-25 | 2015-12-17 | Synthes Gmbh | Osteogenic promoting implants and methods of inducing bone growth |
US8765189B2 (en) | 2011-05-13 | 2014-07-01 | Howmedica Osteonic Corp. | Organophosphorous and multivalent metal compound compositions and methods |
EP2529764A1 (en) | 2011-05-31 | 2012-12-05 | Curasan AG | Biodegradable composite material |
US20150159066A1 (en) | 2011-11-25 | 2015-06-11 | Smith & Nephew Plc | Composition, apparatus, kit and method and uses thereof |
WO2013142763A1 (en) | 2012-03-22 | 2013-09-26 | University Of Connecticut | Biomimetic scaffold for bone regeneration |
US10207027B2 (en) | 2012-06-11 | 2019-02-19 | Globus Medical, Inc. | Bioactive bone graft substitutes |
CN102805881B (en) * | 2012-06-18 | 2014-02-19 | 浙江星月生物科技股份有限公司 | Collagen basal bone cartilage three-layer compound and preparation method thereof |
US20130345826A1 (en) | 2012-06-22 | 2013-12-26 | Collagen Matrix, Inc. | Implants for Bone and Cartilage Repair |
US11253252B2 (en) | 2012-07-30 | 2022-02-22 | Conextions, Inc. | Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone |
US11957334B2 (en) | 2012-07-30 | 2024-04-16 | Conextions, Inc. | Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone |
US10219804B2 (en) | 2012-07-30 | 2019-03-05 | Conextions, Inc. | Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone |
US11944531B2 (en) | 2012-07-30 | 2024-04-02 | Conextions, Inc. | Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone |
US9629632B2 (en) | 2012-07-30 | 2017-04-25 | Conextions, Inc. | Soft tissue repair devices, systems, and methods |
US10835241B2 (en) | 2012-07-30 | 2020-11-17 | Conextions, Inc. | Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone |
US9427309B2 (en) | 2012-07-30 | 2016-08-30 | Conextions, Inc. | Soft tissue repair devices, systems, and methods |
US10390935B2 (en) | 2012-07-30 | 2019-08-27 | Conextions, Inc. | Soft tissue to bone repair devices, systems, and methods |
US9066853B2 (en) * | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
US9381274B2 (en) | 2013-03-14 | 2016-07-05 | Prosidyan, Inc. | Bone graft implants containing allograft |
US8889178B2 (en) | 2013-03-14 | 2014-11-18 | Prosidyan, Inc | Bioactive porous bone graft compositions in synthetic containment |
US8883195B2 (en) | 2013-03-14 | 2014-11-11 | Prosidyan, Inc. | Bioactive porous bone graft implants |
US20160120706A1 (en) | 2013-03-15 | 2016-05-05 | Smith & Nephew Plc | Wound dressing sealant and use thereof |
RU2563621C2 (en) * | 2013-09-16 | 2015-09-20 | Федеральное государственное бюджетное учреждение науки Институт физики полупроводников им. А.В. Ржанова Сибирского отделения Российской академии наук (ИФП СО РАН) | Bioresorbable polymer cell matrix |
CN103536965B (en) * | 2013-09-24 | 2014-11-05 | 北京大学口腔医学院 | Preparation method for three-dimensional mineralized collagen bracket with strict grade structure as well as product and application of three-dimensional mineralized collagen bracket |
US9878071B2 (en) | 2013-10-16 | 2018-01-30 | Purdue Research Foundation | Collagen compositions and methods of use |
US9539286B2 (en) | 2013-10-18 | 2017-01-10 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
US9486483B2 (en) | 2013-10-18 | 2016-11-08 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
US9579421B2 (en) | 2014-02-07 | 2017-02-28 | Globus Medical Inc. | Bone grafts and methods of making and using bone grafts |
US9463264B2 (en) | 2014-02-11 | 2016-10-11 | Globus Medical, Inc. | Bone grafts and methods of making and using bone grafts |
US11583384B2 (en) | 2014-03-12 | 2023-02-21 | Conextions, Inc. | Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone |
US9895354B2 (en) | 2014-04-04 | 2018-02-20 | University Of Kentucky Research Foundation | Bilayered calcium sulfate/calcium phosphate space-making composites with multiple drug delivery capabilities |
US9539363B2 (en) * | 2014-04-24 | 2017-01-10 | Warsaw Orthopedic, Inc. | Collagen matrix |
CN104147641B (en) * | 2014-07-11 | 2016-08-31 | 深圳职业技术学院 | A kind of for personalized bone renovating material and its preparation method |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
US10238507B2 (en) | 2015-01-12 | 2019-03-26 | Surgentec, Llc | Bone graft delivery system and method for using same |
WO2016172365A1 (en) | 2015-04-21 | 2016-10-27 | Purdue Research Foundation Office Of Technology Commercialization | Cell-collagen-silica composites and methods of making and using the same |
US10016529B2 (en) | 2015-06-10 | 2018-07-10 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
US11426489B2 (en) | 2015-06-10 | 2022-08-30 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
US9580543B1 (en) * | 2016-02-05 | 2017-02-28 | Xerox Corporation | Method of making branched polyester resin with a target glass transition temperature |
FI127762B (en) | 2016-09-19 | 2019-02-15 | Tty Saeaetioe | Method for producing porous composite material |
US11696822B2 (en) | 2016-09-28 | 2023-07-11 | Conextions, Inc. | Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone |
CN109862834B (en) | 2016-10-27 | 2022-05-24 | Dfine有限公司 | Bendable osteotome with cement delivery channel |
CN106512104A (en) * | 2016-10-31 | 2017-03-22 | 北京奥精医药科技有限公司 | Mineralized collagen-based alveolar bone restoration material and preparation method thereof |
AU2017363356B2 (en) | 2016-11-28 | 2023-02-09 | Dfine, Inc. | Tumor ablation devices and related methods |
EP3551100B1 (en) | 2016-12-09 | 2021-11-10 | Dfine, Inc. | Medical devices for treating hard tissues |
WO2018129180A1 (en) | 2017-01-06 | 2018-07-12 | Dfine, Inc. | Osteotome with a distal portion for simultaneous advancement and articulation |
CN106798949B (en) * | 2017-02-22 | 2019-09-20 | 福建吉特瑞生物科技有限公司 | A kind of porous hydroxyapatite bone renovating material and preparation method thereof |
WO2018200750A1 (en) | 2017-04-25 | 2018-11-01 | Purdue Research Foundation | 3-dimensional (3d) tissue-engineered muscle for tissue restoration |
US11547397B2 (en) | 2017-12-20 | 2023-01-10 | Conextions, Inc. | Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone |
WO2019164853A1 (en) | 2018-02-20 | 2019-08-29 | Conextions, Inc. | Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone |
US11116647B2 (en) | 2018-04-13 | 2021-09-14 | Surgentec, Llc | Bone graft delivery system and method for using same |
US10687828B2 (en) | 2018-04-13 | 2020-06-23 | Surgentec, Llc | Bone graft delivery system and method for using same |
EP3876856A4 (en) | 2018-11-08 | 2022-10-12 | Dfine, Inc. | Tumor ablation device and related systems and methods |
CA3158044A1 (en) | 2019-12-04 | 2021-06-10 | Yuval Zubery | A collagen-hydroxyapatite device for non-surgical periodontal treatment |
US11896736B2 (en) | 2020-07-13 | 2024-02-13 | Globus Medical, Inc | Biomaterial implants and methods of making the same |
CN112494463B (en) * | 2020-11-23 | 2022-10-18 | 潍坊医学院 | Berberine/mineralized collagen composite membrane as well as preparation method and application thereof |
CN114425104B (en) * | 2021-12-21 | 2023-03-03 | 中国人民解放军空军军医大学 | Medicine-carrying bone guiding/inducing composite structure and preparation method and application thereof |
WO2023150739A2 (en) * | 2022-02-07 | 2023-08-10 | Moskovitz Martin J | Cryo-surgical device and materials and method of use thereof |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1271763A (en) * | 1969-05-12 | 1972-04-26 | Fmc Corp | New or improved structures for example, prstuetic structures, and a method of preparing them |
US4455256A (en) * | 1981-05-05 | 1984-06-19 | The Regents Of The University Of California | Bone morphogenetic protein |
US4294753A (en) * | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
US4440750A (en) * | 1982-02-12 | 1984-04-03 | Collagen Corporation | Osteogenic composition and method |
US4434094A (en) * | 1983-04-12 | 1984-02-28 | Collagen Corporation | Partially purified osteogenic factor and process for preparing same from demineralized bone |
US4789663A (en) * | 1984-07-06 | 1988-12-06 | Collagen Corporation | Methods of bone repair using collagen |
US4627982A (en) * | 1984-07-16 | 1986-12-09 | Collagen Corporation | Partially purified bone-inducing factor |
US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
US4888366A (en) * | 1984-10-24 | 1989-12-19 | Collagen Corporation | Inductive collagen-based bone repair preparations |
CA1260391A (en) * | 1985-03-28 | 1989-09-26 | Karl A. Piez | Xenogeneic collagen/mineral preparations in bone repair |
US5246457A (en) * | 1985-03-28 | 1993-09-21 | Collagen Corporation | Xenogeneic collagen/mineral preparations in bone repair |
US4780450A (en) * | 1985-12-20 | 1988-10-25 | The University Of Maryland At Baltimore | Physically stable composition and method of use thereof for osseous repair |
US4698326A (en) * | 1985-12-20 | 1987-10-06 | Regents Of The University Of Minnesota | Composition and method for osseous repair |
US5133755A (en) * | 1986-01-28 | 1992-07-28 | Thm Biomedical, Inc. | Method and apparatus for diodegradable, osteogenic, bone graft substitute device |
US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
US5306311A (en) * | 1987-07-20 | 1994-04-26 | Regen Corporation | Prosthetic articular cartilage |
WO1989004646A1 (en) * | 1987-11-13 | 1989-06-01 | Jefferies Steven R | Bone repair material and delayed drug delivery |
US4863732A (en) * | 1987-12-16 | 1989-09-05 | Collagen Corporation | Injectable composition for inductive bone repair |
GB2215209B (en) | 1988-03-14 | 1992-08-26 | Osmed Inc | Method and apparatus for biodegradable, osteogenic, bone graft substitute device |
US4975526A (en) * | 1989-02-23 | 1990-12-04 | Creative Biomolecules, Inc. | Bone collagen matrix for zenogenic implants |
GB8819755D0 (en) * | 1988-08-19 | 1988-09-21 | Geistlich Soehne Ag | Chemical compound |
US5264214A (en) * | 1988-11-21 | 1993-11-23 | Collagen Corporation | Composition for bone repair |
US5162430A (en) * | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
US5092883A (en) * | 1988-12-28 | 1992-03-03 | Eppley Barry L | Method for promoting soft connective tissue growth and repair in mammals |
DE3907663A1 (en) * | 1989-03-09 | 1990-09-13 | Espe Stiftung | BONE REPLACEMENT FROM GLASIONOMIC CEMENT |
WO1991001720A1 (en) * | 1989-08-07 | 1991-02-21 | Herman Wade Schlameus | Composition and method of promoting hard tissue healing |
US5236456A (en) * | 1989-11-09 | 1993-08-17 | Osteotech, Inc. | Osteogenic composition and implant containing same |
US5071655A (en) * | 1990-01-12 | 1991-12-10 | Baylink David J | Pharmaceutical combination for treatment of bone-wasting diseases |
US5645591A (en) * | 1990-05-29 | 1997-07-08 | Stryker Corporation | Synthetic bone matrix |
US5219998A (en) * | 1990-06-04 | 1993-06-15 | Levin Robert H | Yeast-derived epidermal growth factor |
ATE139126T1 (en) * | 1990-09-10 | 1996-06-15 | Synthes Ag | MEMBRANE FOR BONE REGENERATION |
US5231169A (en) * | 1990-10-17 | 1993-07-27 | Norian Corporation | Mineralized collagen |
CA2071912C (en) * | 1990-11-30 | 2002-10-15 | Hanne Bentz | Use of a bone morphogenetic protein in synergistic combination with tgf-beta for bone repair |
US5208219A (en) * | 1991-02-14 | 1993-05-04 | Celtrix Pharmaceuticals Inc. | Method for inducing bone growth |
US5149691A (en) * | 1991-03-12 | 1992-09-22 | Creative Biomolecules, Inc. | Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone |
JP3064470B2 (en) * | 1991-04-19 | 2000-07-12 | 杉郎 大谷 | Artificial prosthetic materials |
JPH07500315A (en) * | 1991-05-10 | 1995-01-12 | セルトリックス ファーマシューティカルズ,インコーポレイテッド | Targeted delivery of bone growth factors |
DE4120325A1 (en) * | 1991-06-20 | 1992-12-24 | Merck Patent Gmbh | IMPLANT MATERIAL |
DE4121043A1 (en) * | 1991-06-26 | 1993-01-07 | Merck Patent Gmbh | BONE REPLACEMENT MATERIAL WITH FGF |
US5356629A (en) | 1991-07-12 | 1994-10-18 | United States Surgical Corporation | Composition for effecting bone repair |
US5270300A (en) * | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
US5306303A (en) * | 1991-11-19 | 1994-04-26 | The Medical College Of Wisconsin, Inc. | Bone induction method |
US6013853A (en) * | 1992-02-14 | 2000-01-11 | The University Of Texas System | Continuous release polymeric implant carrier |
WO1993015694A1 (en) * | 1992-02-14 | 1993-08-19 | Board Of Regents, The University Of Texas System | Multi-phase bioerodible implant/carrier and method of manufacturing and using same |
US5876452A (en) * | 1992-02-14 | 1999-03-02 | Board Of Regents, University Of Texas System | Biodegradable implant |
DE69302680D1 (en) * | 1992-02-21 | 1996-06-20 | Ici Plc | OXIDATION CATALYSTS |
US5532217A (en) * | 1992-04-24 | 1996-07-02 | Silver; Frederick H. | Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone |
IL106159A0 (en) * | 1992-06-30 | 1993-10-20 | Dow Chemical Co | Targeted delivery of growth factors for bone regeneration |
WO1994001483A1 (en) | 1992-07-02 | 1994-01-20 | Collagen Corporation | Biocompatible polymer conjugates |
WO1994015653A1 (en) * | 1993-01-12 | 1994-07-21 | Genentech, Inc. | Tgf-beta formulation for inducing bone growth |
US5531794A (en) * | 1993-09-13 | 1996-07-02 | Asahi Kogaku Kogyo Kabushiki Kaisha | Ceramic device providing an environment for the promotion and formation of new bone |
JP3061732B2 (en) * | 1993-09-13 | 2000-07-10 | 旭光学工業株式会社 | Ceramics functional material providing a place for osteoinduction and bone formation, and method for producing the same |
US6201039B1 (en) * | 1993-09-21 | 2001-03-13 | The Penn State Research Foundation | Bone substitute composition comprising hydroxyapatite and a method of production therefor |
JP3410195B2 (en) * | 1994-02-28 | 2003-05-26 | テルモ株式会社 | Composite material of bioabsorbable plastic and collagen |
US5577792A (en) * | 1995-02-21 | 1996-11-26 | Prince Corporation | Multiple visor system with aligned pivot axes |
US6902584B2 (en) * | 1995-10-16 | 2005-06-07 | Depuy Spine, Inc. | Bone grafting matrix |
US5776193A (en) | 1995-10-16 | 1998-07-07 | Orquest, Inc. | Bone grafting matrix |
-
1996
- 1996-04-17 US US08/633,554 patent/US5776193A/en not_active Expired - Lifetime
- 1996-10-15 CA CA002232986A patent/CA2232986C/en not_active Expired - Fee Related
- 1996-10-15 JP JP51593297A patent/JP4275732B2/en not_active Expired - Lifetime
- 1996-10-15 PT PT96937686T patent/PT855884E/en unknown
- 1996-10-15 NZ NZ321756A patent/NZ321756A/en not_active IP Right Cessation
- 1996-10-15 ES ES96937686T patent/ES2224182T3/en not_active Expired - Lifetime
- 1996-10-15 DE DE69632829T patent/DE69632829T2/en not_active Expired - Lifetime
- 1996-10-15 AT AT96937686T patent/ATE270078T1/en active
- 1996-10-15 CN CNB961988835A patent/CN1172724C/en not_active Expired - Fee Related
- 1996-10-15 WO PCT/US1996/016496 patent/WO1997014376A1/en active IP Right Grant
- 1996-10-15 DK DK96937686T patent/DK0855884T3/en active
- 1996-10-15 AU AU75167/96A patent/AU705303B2/en not_active Expired
- 1996-10-15 EP EP96937686A patent/EP0855884B1/en not_active Expired - Lifetime
-
1998
- 1998-07-07 US US09/110,726 patent/US6187047B1/en not_active Expired - Lifetime
-
2002
- 2002-02-22 US US10/086,225 patent/US6764517B2/en not_active Expired - Lifetime
-
2003
- 2003-02-21 AT AT03709281T patent/ATE490744T1/en active
- 2003-02-21 AU AU2003213235A patent/AU2003213235B2/en not_active Ceased
- 2003-02-21 WO PCT/US2003/005426 patent/WO2003071991A1/en active IP Right Grant
- 2003-02-21 CA CA2476929A patent/CA2476929C/en not_active Expired - Fee Related
- 2003-02-21 EP EP03709281A patent/EP1482872B1/en not_active Expired - Lifetime
- 2003-02-21 CN CN038089807A patent/CN1646070B/en not_active Expired - Fee Related
- 2003-02-21 NZ NZ535466A patent/NZ535466A/en not_active IP Right Cessation
-
2004
- 2004-05-27 US US10/856,981 patent/US7842097B2/en not_active Expired - Fee Related
-
2006
- 2006-10-04 JP JP2006272877A patent/JP4526525B2/en not_active Expired - Lifetime
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