CA2476929A1 - Tissue repair matrix - Google Patents

Tissue repair matrix Download PDF

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Publication number
CA2476929A1
CA2476929A1 CA002476929A CA2476929A CA2476929A1 CA 2476929 A1 CA2476929 A1 CA 2476929A1 CA 002476929 A CA002476929 A CA 002476929A CA 2476929 A CA2476929 A CA 2476929A CA 2476929 A1 CA2476929 A1 CA 2476929A1
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Canada
Prior art keywords
matrix
collagen
binder
soluble
acid
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Granted
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CA002476929A
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French (fr)
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CA2476929C (en
Inventor
Michael K. Kwan
Stephen D. Pacetti
Ronald K. Yamamoto
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DePuy Spine LLC
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Individual
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
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    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
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    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
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    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
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    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30092—Properties of materials and coating materials using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
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    • A61L2430/00—Materials or treatment for tissue regeneration
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Abstract

A porous three-dimensional tissue repair matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium phosphate immobilized in the matrix.

Claims (26)

1. An implantable porous, biodegradable, three-dimensionally fixed matrix having shape memory comprising a network of water-insoluble mineralized biopolymer fibers, a drug and a water-soluble binder which is rendered insoluble by cross-linking.
2. An implantable, porous, biodegradable, three-dimensionally fixed matrix for bone growth having shape memory which maintains its porosity for a period greater than about fourteen days after implant into a physiological environment in which said bone growth is required, comprising insoluble mineralized biopolymer fibers, a drug and a water-soluble binder which is rendered insoluble by cross-linking.
3. A matrix according to claim 1 or 2 wherein said matrix is compressible from its initial size, shape and porosity and returns from a compressed state without substantial loss of said fibers or binder.
4. A matrix according to claim 1 or 2 wherein said drug comprises an antibiotic.
5. A matrix according to claim 1 or 2 further comprising a growth factor.
6. A matrix according to claim 1 or 2 further comprising marrow.
7. A matrix according to claims 1 or 2 wherein said binder is selected from the group consisting of soluble collagen, gelatin, polylactic acid, polyglycolic acid, copolymers of lactic and glycolic acid, polycaprolactone, carboxymethylcellulose, cellulose esters, dextrose, dextran, chitosan, hyaluronic acid, ficol, chondroitin sulfate, polyvinyl alcohol, polyacrylic acid, polypropylene glycol, polyethylene glycol, water soluble polyacrylates and water soluble polymethacrylates.
8. A matrix according to claim 1 or 2 wherein said biopolymer comprises fibrillar collagen.
9. A matrix according to claim 1 or 2 wherein said mineral comprises hydroxyapatite.
10. A matrix according to claim 2 wherein said mineral is released into said physiological environment during replacement with bone in a time-release profile which maintains said porosity for said period of time.
11. A matrix according to claim 1 or 2 wherein said mineralized biopolymer fibers are in the form of mineralized collagen containing about 30-95% by weight of collagen.
12. A matrix according to claim 1 or 2 further comprising autogenous bone.
13. A method of repairing fibrous tissue or cartilage comprising the step of introducing to a target site of repair a composition comprising are effective amount of a porous, biodegradable, three-dimensionally fixed matrix having shape memory comprising insoluble mineralized biopolymer fibers and a water-soluble binder which is rendered insoluble by cross-linking, sufficient to promote new fibrous tissue or cartilage formation.
14. A method of repairing fibrous tissue, cartilage or bone comprising the steps of:
(a) introducing a delivery vehicle to a target site of repair, said vehicle containing a porous, biodegradable, three-dimensionally fixed matrix having shape memory comprising insoluble mineralized biopolymer fibers and a water-soluble binder which is rendered insoluble by cross-linking in a compressed state relative to the initial size, shape acid porosity of said matrix; and (b) releasing said matrix from said delivery vehicle whereby said matrix returns to said initial size, shape and porosity.
15. A method according to claim 13 or 14 wherein said matrix returns to said initial size, shape and porosity without loss of a substantial amount of said fibers and binder.
16. A method according to claims 13 or 14 wherein said matrix further comprising an additive.
17. A method according to claim 16 wherein said additive comprises a drug.
18. A method according to claim 17 wherein said drug comprises an antibiotic.
19. A method according to claim 16 wherein said additive comprises a growth factor.
20. A method according to claim 13 or 14 wherein said matrix further comprises marrow.
21. A method according to claim 13 or 14 wherein said binder is selected from the group consisting of soluble collagen, gelatin, polylactic acid, polyglycolic acid, copolymers of lactic and glycolic acid, polycaprolactone, carboxymethylcellulose, cellulose esters, dextrose, dextran, chitosan, hyaluronic acid, ficol, chondroitin sulfate, polyvinyl alcohol, polyacrylic acid, polypropylene glycol, polyethylene glycol, water soluble polyacrylates and water soluble polymethacrylates.
22. A method according to claim 13 or 14 wherein said biopolymer comprises fibrillar collagen.
23. A method according to claim 13 or 14 wherein the mineral of said mineralized biopolymer fibers comprises hydroxyapatite.
24. A method according to claim 13 or 14 wherein said matrix comprises collagen and immobilized calcium phosphate in the form of mineralized collagen containing about 30-95% by weight of collagen.
25. A method according to claim 13 or 14 wherein said matrix further comprises autogenous bone.
26. A method according to claim 21 wherein said binder comprises soluble collagen.
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US08/633,554 US5776193A (en) 1995-10-16 1996-04-17 Bone grafting matrix
US10/086,225 US6764517B2 (en) 1995-10-16 2002-02-22 Tissue repair matrix
US10/086,225 2002-02-22
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