CA2497103A1 - Microabrader with controlled abrasion features - Google Patents

Microabrader with controlled abrasion features Download PDF

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Publication number
CA2497103A1
CA2497103A1 CA002497103A CA2497103A CA2497103A1 CA 2497103 A1 CA2497103 A1 CA 2497103A1 CA 002497103 A CA002497103 A CA 002497103A CA 2497103 A CA2497103 A CA 2497103A CA 2497103 A1 CA2497103 A1 CA 2497103A1
Authority
CA
Canada
Prior art keywords
abrader
skin
housing
delivery site
push button
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002497103A
Other languages
French (fr)
Other versions
CA2497103C (en
Inventor
Alexander G. Lastovich
Frank E. Martin
M. Ishaq Haider
Richard P. Clarke
Jason B. Alarcon
John A. Mikszta
John P. Dekker, Iii
Weston Harding
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2497103A1 publication Critical patent/CA2497103A1/en
Application granted granted Critical
Publication of CA2497103C publication Critical patent/CA2497103C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Abstract

An abrader device for delivering a substance into skin via an abrasion proce ss includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed, in an upper opening of the housi ng and movable across a lower opening of the housing to abrade the delivery sit e in at least one furrow, and an abrader surface attached to the applicator he ad whereby the housing remains firm and stationary at the delivery site and structure of the housing and the applicator head controls parameters of the abrasion process. In particular, the amount of force or pressure applied to the abrader surface, the speed at which the abrader surface moves across the skin and the number of lateral passes of the abrader surface across the skin are controlled so that the abrader device provides a furrow with a length of substantially the same depth thereby providing reproducible results, even though different technicians are applying the abrader device against a patient's skin.

Claims (10)

1. An abrader device for delivering a substance into skin via an abrasion process, said abrader device comprising:
a base having a top surface and a bottom surface onto which an abrader surface with microprotrusions is mounted, said microprotrusions having at least one scraping edge for forming a furrow along a length of the skin;
a handle projecting from the top surface of the base; and means for controlling the amount of force or pressure applied to the microprotrusions as the abrader surface moves across the skin thereby forming a furrow of a substantially consistent depth along its length wherein said means for controlling the amount of force or pressure is a preloaded spring that deflects only if a sufficient amount of pressure is present.
2. The abrader device according to Claim 1, further comprising a housing surrounding the base; wherein the handle is a push button that collapses inside the base when activated, and the base rotates with respect to the housing and proportionally to the push button collapse, thereby causing the abrader surface to rotate against skin when the housing is placed against skin.
3. The abrader device according to Claim 1, wherein said handle has an upper portion and a lower portion, said upper portion capable of collapsing onto said lower portion and said means for controlling the amount of force includes a spring surrounding a post where the spring and post are disposed in said lower portion and extend to said upper portion of the handle.
4. The abrader device according to Claim 3, wherein said means for controlling the amount of force is a printed matter gauge wherein the printed matter gauge is coded in proportion to the amount of force applied.
5. An abrader device for delivering a substance into skin via an abrasion process, said abrader device comprising:
a housing adapted to be pressed against the skin at a desired delivery site, said housing having a top with an upper opening and a bottom defining a lower opening, which surrounds the delivery site;
an applicator head disposed in the upper opening and movable across the lower opening to abrade the delivery site; and an abrader surface attached to said applicator head whereby said housing remains firm and stationary at the delivery site and structure of said housing and said applicator head controls parameters of the abrasion process.
6. The abrader device according to Claim 5, wherein the structure of said housing that controls the abrasion process is a track that determines at least one of the length of the abraded area and the depth of penetration of the abrader surface into the skin at the delivery site.
7. The abrader device according to Claim 5, further comprising means for moving said applicator head and abrader surface across the delivery site.
8. An automatic abrader device for delivering a substance into skin via an abrasion process, said abrader device comprising:
a housing adapted to be fixedly attached to the skin at a desired delivery site, said housing having a top with an upper opening and a bottom with a lower opening;
a push button arranged to project through the upper opening of the housing;
a spring mechanism surrounding the push button;

a series of one or more levers or perpendicularly arranged horizontal bars in operable communication with said push button; and an abrader surface movable across the lower opening of the housing to abrade the delivery site and in operable communication with said push button and said series of one or more levers or perpendicularly arranged horizontal bars wherein when the push button is pressed or activated said abrader surface moves into contact with the skin at the delivery site and moves across the delivery site in one direction in conjunction with the movement of said series of one of levers or perpendicularly arranged horizontal bars.
9. An abrader device for delivering a substance into skin via an abrasion process, said abrader device comprising:
a housing adapted to be attached to the skin at a desired delivery site, said housing having a top with an upper opening and a bottom with a lower opening, said lower opening facing the skin;
a push button arranged to project through the upper opening of the housing the push button having a first camming surface;
an abrader surface movable across the lower opening of the housing to abrade the delivery site and having a second camuning surface in operable communication with said first camming surface wherein when said push button is pressed or activated said abrader surface moves into contact with the skin at the delivery site and moves across the delivery site from a first position to a second position in conjunction with the movement of said push button.
10. The abrader device according to Claim 9, further comprising a biasing spring wherein said biasing spring biases said abrader surface towards said first position.
CA2497103A 2002-08-29 2003-08-27 Microabrader with controlled abrasion features Expired - Fee Related CA2497103C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40669402P 2002-08-29 2002-08-29
US60/406,694 2002-08-29
PCT/US2003/026811 WO2004020034A2 (en) 2002-08-29 2003-08-27 Microabrader with controlled abrasion features

Publications (2)

Publication Number Publication Date
CA2497103A1 true CA2497103A1 (en) 2004-03-11
CA2497103C CA2497103C (en) 2011-07-19

Family

ID=31978342

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2497154A Expired - Fee Related CA2497154C (en) 2002-08-29 2003-08-27 Substance delivery via a rotating microabrading surface
CA2497103A Expired - Fee Related CA2497103C (en) 2002-08-29 2003-08-27 Microabrader with controlled abrasion features
CA2497128A Expired - Fee Related CA2497128C (en) 2002-08-29 2003-08-27 Microprotrusion arrays and methods for using same to deliver substances into tissue

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2497154A Expired - Fee Related CA2497154C (en) 2002-08-29 2003-08-27 Substance delivery via a rotating microabrading surface

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2497128A Expired - Fee Related CA2497128C (en) 2002-08-29 2003-08-27 Microprotrusion arrays and methods for using same to deliver substances into tissue

Country Status (7)

Country Link
US (5) US7316671B2 (en)
EP (4) EP1531895B1 (en)
JP (3) JP4460451B2 (en)
AU (3) AU2003268205B2 (en)
CA (3) CA2497154C (en)
ES (4) ES2617576T3 (en)
WO (3) WO2004020034A2 (en)

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