CA2499369A1 - Cassette and embedding assembly, staging devices, and methods for handling tissue samples - Google Patents

Cassette and embedding assembly, staging devices, and methods for handling tissue samples Download PDF

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Publication number
CA2499369A1
CA2499369A1 CA002499369A CA2499369A CA2499369A1 CA 2499369 A1 CA2499369 A1 CA 2499369A1 CA 002499369 A CA002499369 A CA 002499369A CA 2499369 A CA2499369 A CA 2499369A CA 2499369 A1 CA2499369 A1 CA 2499369A1
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CA
Canada
Prior art keywords
cassette
side walls
bottom wall
tissue sample
ribs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002499369A
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French (fr)
Other versions
CA2499369C (en
Inventor
Warren P. Williamson, Iv
Craig B. Berky
Stephen P. Whitlatch
Thomas J. Ward
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Biopath Automation LLC
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Individual
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Filing date
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Publication of CA2499369A1 publication Critical patent/CA2499369A1/en
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Publication of CA2499369C publication Critical patent/CA2499369C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/043—Hinged closures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N2001/315—Basket-type carriers for tissues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G01N2001/366—Moulds; Demoulding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2525—Stabilizing or preserving
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Abstract

The disclosure relates to a cassette (10), frame (12) and mold (14) for holding a tissue sample (80) during an embedding and microtoming process, and related methods. The cassette (10) is sectionable in a microtome and includes a body (20) with a bottom wall (24) and a plurality of side walls (22a-22d).
First and second side walls (22a-22c) are generally V-shaped to present an apex of the "V" to the microtome blade. A lid (32) of the cassette (10) is stiffer than the bottom wall (24) of the cassette (10) to assist with positioning the tissue sample (80). The side walls (22a-22d) of the cassette are perforated so as to significantly reduce the amount of cassette material that must be cut by the microtome blade. In one embodiment, to additionally reduce blade wear the ribs (128) on one side wall (124a) are offset lengthwise relative to the ribs (128) on an opposite side wall (124b). An upper flange (140) of the cassette includes depressions (142a-142f) configured to register with detents (54, 56 and 58, 60) in the frame (12).

Claims (39)

1, ~A cassette for holding a tissue sample, comprising:
a body including a perforated bottom wall and a plurality of perforated side walls extending upwardly with respect to said bottom wall to define an interior space for receiving the tissue sample;
said bottom wall and said plurality of side walls being constructed of a material capable of being successfully sectioned in a microtome and resistant to degradation during histologic tissue processing, wherein said plurality of side walls comprise first and second side walls on opposite sides of said bottom wall each including portions angling from approximate midpoints of the first and second side walls toward the other of the first and second side walls on the opposite side of the bottom wall.
2, ~The cassette of claim 1, further comprising a lid configured to be coupled with said body and movable between open and closed positions, said lid being stiffer than said bottom wall.
3. ~The cassette of claim 1, wherein said plurality of side walls comprise perforated walls in which the ratio of open area to solid area is at least about 3.5:1.
4. ~The cassette of claim 1, wherein said plurality of side walls comprise perforated walls in which the ratio of open area to solid area is at least about 3.0:1.
5, ~The cassette of claim 1, wherein said plurality of side walls comprise perforated walls in which the ratio of open area to solid area is at least about 2.5:1.
6. ~The cassette of claim 1, wherein said first and second side walls include a length and comprise perforated walls constructed with spaced apart ribs, said ribs of said first side wall being offset along said length with respect to said ribs of said second side wall.
7. ~The cassette of claim 1, further comprising:
a flange extending along upper portions of at least two of said side walls, said flange including depressions configured to register with detents in a frame during a tissue embedding process.
8. ~The cassette of claim 1, wherein said bottom wall includes a central area and comprises a perforated wall constructed with spaced apart ribs, said ribs angling toward said central area.
9,~A cassette for holding a tissue sample, comprising:
a body including a bottom wall and a plurality of side walls extending upwardly with respect to said bottom wall to define an interior space for receiving the tissue sample, said bottom wall and said plurality of side walls being constructed of a material capable of being successfully sectioned in a microtome; and a lid configured to be coupled with said body and movable between open and closed positions, said lid being stiffer than said bottom wall.
10. ~The cassette of claim 9, wherein said plurality of side walls comprise perforated walls in which the ratio of open area to solid area is at least about 3.5:1.
11. ~The cassette of claim 9, wherein said plurality of side walls comprise perforated walls in which the ratio of open area to solid area is at least about 3.0:1.
12. ~The cassette of claim 9, said plurality of side walls comprise perforated walls in which the ratio of open area to solid area is at least about 2.5:1.
13. ~The cassette of claim 9, wherein said first and second side walls include a length and comprise perforated walls constructed with spaced apart ribs, said ribs of said first side wall being offset along said length with respect to said ribs of said second side wall.
14. ~The cassette of claim 9, further comprising:
a flange extending along upper portions of at least two of said side walls, said flange including depressions configured to register with detents in a frame during a tissue embedding process.
15. ~The cassette of claim 9, wherein said bottom wall includes a central area and comprises a perforated wall constructed with spaced apart ribs, said ribs angling toward said central area.
16. ~A cassette for holding a tissue sample, comprising:
a body including a bottom wall and a plurality of side walls extending upwardly with respect to said bottom wall to define an interior space for receiving the tissue sample, said bottom wall and said plurality of side walls being constructed of a material capable of being successfully sectioned in a microtome;
wherein said plurality of side walls comprise perforated walls in which the ratio of open area to solid area is at least about 2.5:1.
17. ~The cassette of claim 16, wherein said plurality of side walls comprise perforated walls in which the ratio of open area to solid area is at least about 3.0:1.
18. The cassette of claim 16, wherein said plurality of side walls comprise perforated walls in which the ratio of open area to solid area is at least about 3.5:1.
19. The cassette of claim 16, wherein said first and second side walls include a length and comprise perforated walls constructed with spaced apart ribs, said ribs of said first side wall being offset along said length with respect to said ribs of said second side wall.
20. The cassette of claim 16, further comprising:
a flange extending along upper portions of at least two of said side walls, said flange including depressions configured to register with detents in a frame during a tissue embedding process.
21. The cassette of claim 16, wherein said bottom wall includes a central area and comprises a perforated wall constructed with spaced apart ribs, said ribs angling toward said central area.
22. A cassette for holding a tissue sample, comprising:
a body including a bottom wall and a plurality of side walls extending upwardly with respect to said bottom wall to define an interior space for receiving the tissue sample, said bottom wall and said plurality of side walls being constructed of a material capable of being successfully sectioned in a microtome and said plurality of side walls comprising first and second side walls on opposite sides of said bottom wall, and wherein said first and second side walls include a length and comprise perforated walls constructed with spaced apart ribs, said ribs of said first side wall being offset along said length with respect to said ribs of said second side wall.
23. The cassette of claim 22, wherein said plurality of side walls comprise perforated walls in which the ratio of open area to solid area is at least about 3.5:1.
24. The cassette of claim 22, wherein said plurality of side walls comprise perforated walls in which the ratio of open area to solid area is at least about 3.0:1.
25. The cassette of claim 22, further comprising:
a flange extending along upper portions of at least two of said side walls, said flange including depressions configured to register with detents in a frame during a tissue embedding process.
26. The cassette of claim 22, wherein said bottom wall includes a central area and comprises a perforated wall constructed with spaced apart ribs, said ribs of said bottom wall angling toward said central area.
27. A cassette for holding a tissue sample, comprising:
a body including a bottom wall and a plurality of side walls extending upwardly with respect to said bottom wall to define an interior space for receiving the tissue sample, said bottom wall and said plurality of side walls being constructed of a material capable of being successfully sectioned in a microtome; and a flange extending outwardly along upper portions of at least two of said side walls, said flange including depressions configured to register with detents in a frame during a tissue embedding process.
28. An assembly for embedding a tissue sample prior to a microtoming procedure used to obtain slices of the embedded tissue sample, the assembly comprising:
a cassette for holding the tissue sample and having 1) a body including a bottom wall and a plurality of side walls extending upwardly with respect to said bottom wall to define an interior space for receiving the tissue sample, said bottom wall and said plurality of side walls being constructed of a material capable of being successfully sectioned in a microtome; and 2) a flange extending outwardly along upper portions of at least two of said side walls, said flange including a plurality of depressions; and a frame configured to receive said cassette, said frame including upper detents and lower detents engagable with said flange to define upper and lower positions of said cassette in said frame, said lower detents registering with said depressions.
29. The assembly of claim 28, wherein said depressions are on upper and lower sides of said flange and each registers with a separate detent of said frame.
30. An assembly for embedding a tissue sample prior to a microtoming procedure used to obtain slices of the embedded tissue sample, the assembly comprising:
a microtome sectionable cassette for holding the tissue sample;
a frame configured to receive and hold said cassette;
a base mold having an interior configured to receive embedding material; and a holding member configured to hold said frame against said base mold while the embedding material is introduced into the base mold.
31. The assembly of claim 30, wherein said frame includes outer walls and said holding member further comprises:
a resilient seal engagable with said outer walls to prevent leakage of liquid embedding material from said base mold after introduction thereof through said cassette and frame.
32. A device for staging a tissue sample cassette from an upper position in a frame used during a tissue embedding process to a lower position in the frame, the device comprising:
a handle;
a staging mechanism coupled with said handle and configured to engage an upper surface of the cassette; and a stop operatively coupled to said handle and configured to stop vertical movement of said staging mechanism when the cassette reaches the lower position in the frame.
33. The device of claim 32, wherein the stop comprises a fixed stop member coupled for movement with the staging mechanism and configured to stop against an upper surface of the frame.
34. The device of claim 32, wherein the staging mechanism further comprises a plurality of fingers configured to engage a corresponding plurality of locations on an upper surface of the cassette.
35. The device of claim 32, further comprising:
a stabilizing mechanism coupled with said handle and movable relative to said staging mechanism, said stabilizing mechanism configured to engage an upper surface of the frame as said staging mechanism moves the cassette from the upper position to the lower position.
36. The device of claim 35, wherein said staging mechanism is normally spring biased into an upward position and is forced downward against the spring bias when moving the cassette from the upper position to the lower position.
37. The device of claim 35, wherein said stop further comprises respective surfaces of said handle and said stabilizing mechanism.
38. A method of cutting a slice from a tissue sample contained in a microtome sectionable cassette and embedded in a hardened embedding material, the cassette comprising a body including a bottom wall and a plurality of side walls extending from the bottom wall to define an interior space for receiving the tissue sample, at least a first one of the side walls including portions angling from an approximate midpoint thereof toward a second one of the side walls on the opposite side of the bottom wall, the method comprising:
holding the embedded microtome sectionable cassette in a microtome having a blade with the first one of the side walls facing the blade, and cutting a slice of the cassette, hardened embedding material, and tissue sample with the blade.
39, A method of cutting a slice from a tissue sample contained in a microtome sectionable cassette and embedded in a hardened embedding material, the cassette comprising a body including a bottom wall and a plurality of side walls extending from the bottom wall to define an interior space for receiving the tissue sample, the bottom wall and the plurality of side walls being constructed of a material capable of being successfully sectioned in a microtome and the plurality of side walls comprising first and second side walls on opposite sides of the bottom wall, and wherein the first and second side walls include a length and comprise perforated walls constructed with spaced apart ribs, the ribs of the first side wall being offset along the length with respect to the ribs of the second side wall, the method comprising:
holding the embedded microtome sectionable cassette in a microtome having a blade with one of the first and second side walls facing the blade, and cutting a slice of the cassette, hardened embedding material, and tissue sample with the blade.
CA2499369A 2002-09-26 2002-09-26 Cassette and embedding assembly, staging devices, and methods for handling tissue samples Expired - Lifetime CA2499369C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/030775 WO2004028693A1 (en) 2002-09-26 2002-09-26 Cassette and embedding assembly, staging devices, and methods for handling tissue samples

Publications (2)

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CA2499369A1 true CA2499369A1 (en) 2004-04-08
CA2499369C CA2499369C (en) 2010-06-29

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US (3) US7776274B2 (en)
EP (2) EP1545775B1 (en)
JP (1) JP4237704B2 (en)
CN (1) CN100518940C (en)
AT (2) ATE471211T1 (en)
AU (2) AU2002341872B2 (en)
BR (1) BR0215894B1 (en)
CA (1) CA2499369C (en)
DE (1) DE60236764D1 (en)
DK (2) DK1545775T3 (en)
ES (2) ES2345482T3 (en)
WO (1) WO2004028693A1 (en)

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