CA2504723A1 - Prosthesis with multiple drugs in discrete unmixed droplets - Google Patents
Prosthesis with multiple drugs in discrete unmixed droplets Download PDFInfo
- Publication number
- CA2504723A1 CA2504723A1 CA002504723A CA2504723A CA2504723A1 CA 2504723 A1 CA2504723 A1 CA 2504723A1 CA 002504723 A CA002504723 A CA 002504723A CA 2504723 A CA2504723 A CA 2504723A CA 2504723 A1 CA2504723 A1 CA 2504723A1
- Authority
- CA
- Canada
- Prior art keywords
- beneficial agent
- prosthesis
- interventional device
- loaded
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
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- B05C13/02—Means for manipulating or holding work, e.g. for separate articles for particular articles
- B05C13/025—Means for manipulating or holding work, e.g. for separate articles for particular articles relatively small cylindrical objects, e.g. cans, bottles
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- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
- G11B7/00—Recording or reproducing by optical means, e.g. recording using a thermal beam of optical radiation by modifying optical properties or the physical structure, reproducing using an optical beam at lower power by sensing optical properties; Record carriers therefor
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
Abstract
An interventional device for delivery of multiple beneficial agents. The device includes a prosthesis having a surface loaded with a plurality of discrete droplets of first and second beneficial agents. The discrete droplets of beneficial agent are loaded along a first controlled trajectory and the second beneficial agent is loaded along a second controlled trajectory. The first controlled trajectory and the second controlled trajectory can be aligned to allow mixing of the first and second beneficial agents prior to being loaded onto the surface of the prosthesis.
Claims (31)
1.~An interventional device for the delivery of multiple beneficial agents, the device comprising:
a prosthesis to be deployed in a lumen, the prosthesis having a surface;
a plurality of discrete droplets of a first beneficial agent loaded on the surface of the prosthesis; and a plurality of discrete droplets of a second beneficial agent loaded on the surface of the prosthesis.
a prosthesis to be deployed in a lumen, the prosthesis having a surface;
a plurality of discrete droplets of a first beneficial agent loaded on the surface of the prosthesis; and a plurality of discrete droplets of a second beneficial agent loaded on the surface of the prosthesis.
2. ~The interventional device of claim 1, wherein the first beneficial agent and the second beneficial agent are incompatible.
3. ~The interventional device of claim 1, wherein the first beneficial agent is dissolved in a first solvent and the second beneficial agent is dissolved in a second solvent, and further wherein the first solvent and the second solvent are immiscible.
4. ~The interventional device of claim 1, wherein the discrete droplets of the first beneficial agent are loaded along a first controlled trajectory and the discrete droplets of the second beneficial agent are loaded along a second controlled trajectory; the first controlled trajectory and the second controlled trajectory being aligned to allow the first beneficial agent and the second beneficial agent to mix prior to being loaded onto the surface of the prosthesis.
5. ~The interventional device of claim 1, wherein the discrete droplets of the first beneficial agent and the discrete droplets of the second beneficial agent mix on the surface of the prosthesis.
6. ~The interventional device of claim 1, wherein the first beneficial agent is dissolved in a solvent and the second beneficial agent causes the first beneficial agent to precipitate out of the solvent.
7. ~The interventional device of claim 1, wherein the first beneficial agent and the second beneficial agent are loaded on the prosthesis in unmixed droplets to provide a selected pattern.
8. ~The interventional device of claim 1, wherein at least one of the first beneficial agent and the second beneficial agent is mixed with a binder prior to being loaded on the prosthesis.
9. ~The interventional device of claim 8, wherein the binder is a phosphorylcholine-linked polymer.
10. ~The interventional device of claim 8, wherein the second beneficial agent cures the binder on the prosthesis with the first beneficial agent mixed therein.
11. ~The interventional device of claim 8, wherein the first beneficial agent is mixed with a binder having a first release rate for delivery of the first beneficial agent.
12. ~The interventional device of claim 11, wherein the second beneficial agent is mixed with a binder having a second release rate for delivery of the second beneficial agent; the first release rate being different than the second release rate.
13. ~The interventional device of claim 1, wherein the prosthesis includes at least one cavity defined therein, the at least one cavity being at least partially loaded with a base material; and further wherein the first beneficial agent and the second beneficial agent are loaded to the base material.
14. ~The interventional device of claim 1, wherein the prosthesis includes at least one cavity, the at least one cavity defining a mouth having a first cross-dimension and a reservoir having a second cross-dimension, the second cross-dimension being greater than the first cross-dimension.
15. The interventional device of claim 1, further including a plurality of discrete droplets of a third beneficial agent loaded on the surface of the prosthesis.
16. ~The interventional device of claim 15, wherein the first beneficial agent is dexamethasone, the second beneficial agent is estradiol, and the third beneficial agent is the rapamycin analog 3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-3-methoxy-4-tetrazol-1-yl)cyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone;23,27-Epoxy-3H-pyrido [2,1-c][1,4] oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone.
17. ~The interventional device of claim 15, wherein the first beneficial agent, the second beneficial agent and the third beneficial agent are each dissolved in a first solvent.
18. ~The interventional device of claim 1, wherein at least one of the first beneficial agent and the second beneficial agent is selected from a group consisting of antithrombotics, anticoagulants, antiplatelet agents, anti-lipid agents, thrombolytics, antiproliferatives, anti-inflammatories, agents that inhibit hyperplasia, smooth muscle cell inhibitors, antibiotics, growth factor inhibitors, cell adhesion inhibitors, cell adhesion promoters, antimitotics, antifibrins, antioxidants, antineoplastics, agents that promote endothelial cell recovery, antiallergic substances, radiopaque agents, viral vectors, antisense compounds, oligionucleotides, cell permeation enhancers, angiogenesis agents, paclitaxel, rapamycin, Everolimus, heparin, estradiol, dexamethasone, analogs thereof, rapamycin analog is 3S,6R,7E,9R,10R,12R,145,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-3-methoxy-4-tetrazol-1-yl)cyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]
oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, and combinations thereof.
oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, and combinations thereof.
19. ~The interventional device of claim 1, further including an overcoat applied over at least a portion of the surface.
20. ~The interventional device of claim 1, wherein beneficial agent is applied to the prosthesis using a fluid jet dispenser having a dispensing element capable of dispensing beneficial agent in discrete droplets, each droplet having a controlled trajectory.
21. ~An interventional device for delivery of beneficial agent, the device comprising:
a prosthesis to be deployed in a lumen, the prosthesis having a first surface and a second surface; the first surface of the prosthesis at least partially loaded with a first beneficial agent;
and the second surface at least partially loaded with a second beneficial agent;
at least one of the first beneficial agent and the second beneficial agent being loaded by a fluid-dispenser having a dispensing element capable of dispensing beneficial agent in discrete droplets, each droplet having a controlled trajectory.
a prosthesis to be deployed in a lumen, the prosthesis having a first surface and a second surface; the first surface of the prosthesis at least partially loaded with a first beneficial agent;
and the second surface at least partially loaded with a second beneficial agent;
at least one of the first beneficial agent and the second beneficial agent being loaded by a fluid-dispenser having a dispensing element capable of dispensing beneficial agent in discrete droplets, each droplet having a controlled trajectory.
22. ~The interventional device of claim 21, wherein the prosthesis has a tubular body when deployed, the tubular body defining a longitudinal axis; and further wherein the first surface of the prosthesis is defined as an inner surface of the tubular body and the second surface of the prosthesis is defined as an outer surface of the tubular body.
23. ~The interventional device of claim 21, wherein at least one of the first beneficial and second beneficial agent is selected from a group consisting of antiplatelet agents, aspirin, cell adhesion promoters, agents that promote endothelial healing, agents that promote migration, angiogenesis promoters, cytokines, anti migrative agents, antifibrins, estradiol, anti-inflammatories, anti-proliferatives, smooth muscle inhibitors, cell adhesion promoters, and 3S,6R,7E,9R,10R,12R,145,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-3-methoxy-4-tetrazol-1-yl)cyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, and combinations thereof.
24. ~The interventional device of claim 21, wherein the prosthesis is defined by a plurality of interconnecting structural members; the first surface of the prosthesis including a first selected set of the structural members and the second surface of the prosthesis including a second selected set of the structural members.
25. ~The interventional device of claim 24, wherein at least one of the first selected set of structural members and the second selected set of structural members defines at least one ring-shaped element extending around a circumference of the tubular body.
26. ~The interventional device of claim 21, wherein the first beneficial agent has a first local areal density and the second beneficial agent has a second local areal density.
27. ~The interventional device of claim 26, wherein at least one of the first local areal density and the second local areal density is uniform across a selected portion of the prosthesis.
28. ~The interventional device of claim 21, wherein at least one of the first local areal density of beneficial agent and the second local areal density is varied across a selected portion of the prosthesis.
29. ~The interventional device of claim 21, further including a third beneficial agent loaded on at least one of the first surface and second surface of the prosthesis.
30. ~The interventional device of claim 21, the prosthesis further includes a base material layer, the base material layer defining a pattern on the prosthesis for loading the beneficial agent.
31. ~The interventional device of claim 21, further including an overcoat applied to at least one of the inner surface or the outer surface of the prosthesis.
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
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US42457502P | 2002-11-07 | 2002-11-07 | |
US42457702P | 2002-11-07 | 2002-11-07 | |
US42457602P | 2002-11-07 | 2002-11-07 | |
US42460702P | 2002-11-07 | 2002-11-07 | |
US42457402P | 2002-11-07 | 2002-11-07 | |
US60/424,575 | 2002-11-07 | ||
US60/424,607 | 2002-11-07 | ||
US60/424,574 | 2002-11-07 | ||
US60/424,577 | 2002-11-07 | ||
US60/424,576 | 2002-11-07 | ||
PCT/US2003/035627 WO2004043300A1 (en) | 2002-11-07 | 2003-11-07 | Prosthesis with multiple drugs in discrete unmixed droplets |
Publications (2)
Publication Number | Publication Date |
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CA2504723A1 true CA2504723A1 (en) | 2004-05-27 |
CA2504723C CA2504723C (en) | 2012-10-16 |
Family
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Application Number | Title | Priority Date | Filing Date |
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CA002505367A Abandoned CA2505367A1 (en) | 2002-11-07 | 2003-11-07 | Prosthesis having varied concentration of beneficial agent |
CA2520368A Expired - Fee Related CA2520368C (en) | 2002-11-07 | 2003-11-07 | Method of loading beneficial agent to a prosthesis by fluid-jet application |
CA2504723A Expired - Fee Related CA2504723C (en) | 2002-11-07 | 2003-11-07 | Prosthesis with multiple drugs in discrete unmixed droplets |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
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CA002505367A Abandoned CA2505367A1 (en) | 2002-11-07 | 2003-11-07 | Prosthesis having varied concentration of beneficial agent |
CA2520368A Expired - Fee Related CA2520368C (en) | 2002-11-07 | 2003-11-07 | Method of loading beneficial agent to a prosthesis by fluid-jet application |
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US (7) | US20040185081A1 (en) |
EP (4) | EP1562517B1 (en) |
JP (3) | JP4917753B2 (en) |
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- 2003-11-07 DE DE60331854T patent/DE60331854D1/en not_active Expired - Lifetime
- 2003-11-07 AU AU2003295419A patent/AU2003295419A1/en not_active Abandoned
- 2003-11-07 US US10/703,820 patent/US7208190B2/en not_active Expired - Fee Related
- 2003-11-07 CA CA002505367A patent/CA2505367A1/en not_active Abandoned
- 2003-11-07 AU AU2003290676A patent/AU2003290676A1/en not_active Abandoned
- 2003-11-07 DE DE60333028T patent/DE60333028D1/en not_active Expired - Lifetime
- 2003-11-07 MX MXPA05004926A patent/MXPA05004926A/en unknown
- 2003-11-07 WO PCT/US2003/035563 patent/WO2004043298A1/en active Application Filing
- 2003-11-07 CA CA2520368A patent/CA2520368C/en not_active Expired - Fee Related
- 2003-11-07 PL PL377190A patent/PL377190A1/en unknown
- 2003-11-07 BR BR0316106-4A patent/BR0316106A/en not_active IP Right Cessation
- 2003-11-07 AT AT03783258T patent/ATE471126T1/en not_active IP Right Cessation
- 2003-11-07 PL PL376752A patent/PL376752A1/en unknown
- 2003-11-07 EP EP03783257A patent/EP1572029B1/en not_active Expired - Lifetime
- 2003-11-07 BR BR0316102-1A patent/BR0316102A/en not_active IP Right Cessation
- 2003-11-07 CA CA2504723A patent/CA2504723C/en not_active Expired - Fee Related
- 2003-11-07 JP JP2004551882A patent/JP2006505355A/en not_active Ceased
- 2003-11-07 EP EP10154000.3A patent/EP2198976A3/en not_active Withdrawn
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2006
- 2006-08-17 US US11/465,396 patent/US7597764B2/en not_active Expired - Fee Related
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2007
- 2007-04-23 US US11/738,839 patent/US7645476B2/en not_active Expired - Fee Related
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2009
- 2009-08-31 US US12/551,413 patent/US8001926B2/en not_active Expired - Fee Related
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2011
- 2011-07-05 US US13/176,319 patent/US20110262621A1/en not_active Abandoned
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