CA2512926A1 - Methods and compositions for inhibition of angiogenesis - Google Patents

Methods and compositions for inhibition of angiogenesis Download PDF

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Publication number
CA2512926A1
CA2512926A1 CA002512926A CA2512926A CA2512926A1 CA 2512926 A1 CA2512926 A1 CA 2512926A1 CA 002512926 A CA002512926 A CA 002512926A CA 2512926 A CA2512926 A CA 2512926A CA 2512926 A1 CA2512926 A1 CA 2512926A1
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disease
use according
angiogenesis
inhibition
compositions
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CA2512926C (en
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Robert D`Amato
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Childrens Medical Center Corp
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The Children's Medical Center Corporation
Robert D`Amato
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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Abstract

The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.

Claims (16)

1. ~Use of thalidomide for the treatment of a disease selected from the group consisting of Vitamin A deficiency, contact lens overwear, chemical burns, trauma, radial keatotomy, rubeosis and pemphigoid.
2. ~Use according to claim 1 wherein the disease is Vitamin A deficiency.
3. ~Use according to claim 1 wherein the disease is contact lens overwear.
4. ~Use according to claim 1 wherein the disease is chemical burns.
5. ~Use according to claim 1 wherein the disease is trauma.
6. ~Use according to claim 1 wherein the disease is radial keatotomy.
7. ~Use according to claim 1 wherein the disease is rubeosis.
8. ~Use according to claim 1 wherein the disease is pemphigoid.
9. ~Use of thalidomide in the manufacture of a medicament for the treatment of a disease~
selected from the group consisting of Vitamin A deficiency, contact lens overwear, chemical burns, trauma, radial keatotomy, rubeosis and pemphigoid.
10. ~Use according to claim 9 wherein the disease is Vitamin A deficiency.
11. ~Use according to claim 9 wherein the disease is contact lens overwear.
12. ~Use according to claim 9 wherein the disease is chemical burns.
13. ~Use according to claim 9 wherein the disease is trauma.
14. ~Use according to claim 9 wherein the disease is radial keatotomy.
15. ~Use according to claim 9 wherein the disease is rubeosis.
16. ~Use according to claim 9 wherein the disease is pemphigoid.~
CA2512926A 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis Expired - Lifetime CA2512926C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2504693A 1993-03-01 1993-03-01
US08/025,046 1993-03-01
US08/168,817 US5629327A (en) 1993-03-01 1993-12-15 Methods and compositions for inhibition of angiogenesis
US08/168,817 1993-12-15
CA002157288A CA2157288C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002157288A Division CA2157288C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Publications (2)

Publication Number Publication Date
CA2512926A1 true CA2512926A1 (en) 1994-09-15
CA2512926C CA2512926C (en) 2010-08-03

Family

ID=26699202

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2512926A Expired - Lifetime CA2512926C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis
CA002342974A Expired - Lifetime CA2342974C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis
CA002157288A Expired - Lifetime CA2157288C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

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CA002342974A Expired - Lifetime CA2342974C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis
CA002157288A Expired - Lifetime CA2157288C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Country Status (20)

Country Link
US (18) US5629327A (en)
EP (4) EP1245229A3 (en)
JP (4) JPH08507767A (en)
KR (1) KR100506043B1 (en)
AT (2) ATE218865T1 (en)
AU (1) AU676722B2 (en)
BR (1) BR9400764A (en)
CA (3) CA2512926C (en)
CO (1) CO4230017A1 (en)
DE (3) DE69430796T2 (en)
DK (2) DK0688211T3 (en)
ES (2) ES2245711T3 (en)
FR (1) FR08C0036I2 (en)
HK (1) HK1052865A1 (en)
LU (1) LU91471I2 (en)
NL (1) NL300358I2 (en)
NZ (4) NZ262676A (en)
PE (1) PE10095A1 (en)
PT (1) PT688211E (en)
WO (1) WO1994020085A1 (en)

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