CA2514078A1 - Wound dressing - Google Patents

Wound dressing Download PDF

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Publication number
CA2514078A1
CA2514078A1 CA002514078A CA2514078A CA2514078A1 CA 2514078 A1 CA2514078 A1 CA 2514078A1 CA 002514078 A CA002514078 A CA 002514078A CA 2514078 A CA2514078 A CA 2514078A CA 2514078 A1 CA2514078 A1 CA 2514078A1
Authority
CA
Canada
Prior art keywords
absorbent core
wound dressing
backing layer
border
compliant element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002514078A
Other languages
French (fr)
Other versions
CA2514078C (en
Inventor
Gudmundur Fertram Sigurjonsson
Thordur M. Elefsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BSN Medical GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32719504&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2514078(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2514078A1 publication Critical patent/CA2514078A1/en
Application granted granted Critical
Publication of CA2514078C publication Critical patent/CA2514078C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A61F13/0203—Adhesive plasters or dressings having a fluid handling member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A61F13/0203—Adhesive plasters or dressings having a fluid handling member
    • A61F13/022—Adhesive plasters or dressings having a fluid handling member having more than one layer with different fluid handling characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A61F13/0203—Adhesive plasters or dressings having a fluid handling member
    • A61F13/0223—Adhesive plasters or dressings having a fluid handling member characterized by parametric properties of the fluid handling layer, e.g. absorbency, wicking capacity, liquid distribution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A61F13/0246—Adhesive plasters or dressings characterised by the skin adhering layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/34—Oils, fats, waxes or natural resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00544—Plasters form or structure
    • A61F2013/00574—Plasters form or structure shaped as a body part
    • A61F2013/00578—Plasters form or structure shaped as a body part conformable; soft or flexible, e.g. elastomeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00544—Plasters form or structure
    • A61F2013/00582—Properties of backing
    • A61F2013/00587—Thickness
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00544—Plasters form or structure
    • A61F2013/00604—Multilayer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00727—Plasters means for wound humidity control
    • A61F2013/00748—Plasters means for wound humidity control with hydrocolloids or superabsorbers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00795—Plasters special helping devices
    • A61F2013/008—Plasters special helping devices easy removing of the protection sheet
    • A61F2013/00804—Plasters special helping devices easy removing of the protection sheet different adhesion of different adhesive layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00846—Plasters with transparent or translucent part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00855—Plasters pervious to air or vapours
    • A61F2013/00885—Plasters pervious to air or vapours impervious, i.e. occlusive bandage

Abstract

A wound dressing including an absorbent core and a backing layer connected thereto. The backing layer defines at least one compliant element disassociated from the distal surface of the absorbent core. The compliant element includes at least one ridge extending outwardly relative to the distal surface of the absorbent core. A method for making the compliant element and connecting the backing layer to the absorbent core includes using a platen in communication with a vacuum and compressed air.

Claims (35)

1. A wound dressing, comprising:
an absorbent core having opposed proximal and distal surfaces, and defining border and central portions along the distal surface thereof; and a liquid impervious, vapor permeable backing layer connected to the absorbent core, said backing layer having at least one compliant element disassociated from the absorbent core.
2. The wound dressing according to claim 1, wherein the at least one compliant element corresponds to an intermediate portion of the absorbent core interposed between the border and central portions thereof.
3. The wound dressing according to claim 2, wherein the absorbent core has a thickness at the central portion thereof that is less than the thickness at the intermediate portion.
4. The wound dressing according to claim 1, wherein the border portion of the absorbent core includes a beveled portion near a peripheral edge thereof.
5. The wound dressing according to claim 1, wherein a thickness of the absorbent core progressively decreases from an outer section of the intermediate portion to the border portion thereof.
6. The wound dressing according to claim 5, wherein the thickness of the absorbent core is at a minimum along a peripheral edge of the border portion.
7. The wound dressing according to claim 1, wherein the backing layer is permanently secured to the absorbent core along the border portion thereof.
8. The wound dressing according to claim 7, wherein the backing layer is sealed along the peripheral edges of the absorbent core.
9. The wound dressing according to claim 1, wherein the border portion of the absorbent core includes at least one beveled portion, said backing layer permanently secured to the absorbent core along the border portion thereof.
10. The wound dressing according to claim 1, wherein said backing layer is attached to the central portion of the absorbent core when said wound dressing is substantially devoid of moisture, said backing layer is configured to disassociate from the central portion of the absorbent core when the wound dressing has absorbed a quantity of moisture.
11. The wound dressing according to claim 1, wherein the compliant element includes at least one ridge concentric to the periphery of the absorbent core extending substantially outwardly relative to the distal surface of the absorbent core.
12. The wound dressing according to claim 1, wherein the compliant element is defined as a portion of the backing layer extending generally co-planar with the distal surface of the absorbent core when the wound dressing is substantially devoid of moisture.
13. The wound dressing according to claim 1, further comprising a perforated, skin adherent facing layer secured to the proximal surface of the absorbent core.
14. The wound dressing according to claim 13, wherein the facing layer is a discrete layer of silicone gel.
15. The wound dressing according to claim 1, wherein the absorbent core is selected from the group consisting of polymeric foam, woven material, and non-woven material.
16. The wound dressing according to claim 1, wherein the backing layer is selected from the group consisting of latex rubber, silicone film, polyurethane film, and polyethylene film.
17. The wound dressing according to claim 1, wherein the absorbent core contains discrete portions of at least one absorbent material.
18. The wound dressing according to claim 17, wherein the discrete portions of absorbent material are enmeshed in the absorbent core.
19. The wound dressing according to claim 18, wherein the absorbent material is selected from the group consisting of hydrocolloids, hydrogels, and hydrophilic polymers.
20. The wound dressing according to claim 17, wherein the discrete portions of absorbent material are disposed in receptacles formed along the distal surface of the absorbent core.
21. A method for making a wound dressing including an absorbent core having proximal and distal surfaces, a liquid impervious, vapor permeable backing layer extending over the distal surface of the absorbent core that includes a portion defining a compliant element disassociated and outwardly extending from the distal surface of the absorbent core, said method comprising the steps of:
securing a border portion of the backing layer to a border portion of the absorbent core located near the periphery thereof;
connecting a central portion of the backing layer to a central portion of the absorbent core; and forming the compliant element by drawing said compliant element away from the absorbent core.
22. The method according to claim 21, wherein the compliant element is drawn from the absorbent core with a vacuum as the border and central portions of the backing layer are connected to the absorbent core.
23. The method according to claim 22, further comprising the step of removing the vacuum from the backing layer.
24. The method according to claim 23, further comprising the step of injecting compressed air against the backing layer after the compliant element has been formed.
25. The method according to claim 21, wherein a platen configured with a predetermined profile corresponding to the compliant element and the border and central portions of the backing layer is employed to secure the backing layer to the absorbent core, the platen including at least one groove defining the form of the compliant element of the backing layer and selectively in communication with a vacuum.
26. The method according to claim 25, further comprising the steps of:
drawing the backing layer against the platen prior to bonding the border and central portions thereof to the absorbent core by pulling the area of the backing layer corresponding to the compliant element into the at least one groove with a vacuum in communication therewith;
applying the platen with the backing layer carried thereon against the absorbent core, said platen being heated at a suitable temperature to secure the border portion of the backing layer to the absorbent core; and removing the vacuum from the backing layer after the border portion of the backing layer is secured to the absorbent core.
27. The method according to claim 25, wherein compressed air is exerted against the central portion of the backing layer to separate the platen therefrom.
28. The method according to claim 25, wherein the platen includes a tapered profile corresponding to an end portion of the border portion adjacent the periphery of the wound dressing, said profile imparting a tapered edge to the wound dressing.
29. The method according to claim 25, wherein the platen includes at least one recessed portion defined along the profile thereof.
30. The method according to claim 29, wherein the at least one recessed portion is defined about a central axis of the platen.
31. The method according to claim 30, wherein the platen includes at least two concentric recessed portions.
32. The method according to claim 21, further comprising the step of sealing the peripheral edges of the absorbent core with the backing layer.
33. The method according to claim 25, wherein the at least one groove is connected to at least one passageway in communication with compressed air.
34. The method according to claim 33, further comprising the step of exerting compressed air via the at least one passageway against the compliant element to form two concentric ridges.
35
CA2514078A 2002-12-31 2003-12-03 Wound dressing Expired - Lifetime CA2514078C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US43714602P 2002-12-31 2002-12-31
US60/437,146 2002-12-31
US48277503P 2003-06-27 2003-06-27
US60/482,775 2003-06-27
US50354603P 2003-09-17 2003-09-17
US60/503,546 2003-09-17
US51831703P 2003-11-10 2003-11-10
US60/518,317 2003-11-10
PCT/US2003/037075 WO2004060225A1 (en) 2002-12-31 2003-12-03 Wound dressing

Publications (2)

Publication Number Publication Date
CA2514078A1 true CA2514078A1 (en) 2004-07-22
CA2514078C CA2514078C (en) 2012-07-10

Family

ID=32719504

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2510977A Expired - Lifetime CA2510977C (en) 2002-12-31 2003-12-03 Wound dressing comprising an absorbent core with a plurality of receptacles formed therein
CA2514078A Expired - Lifetime CA2514078C (en) 2002-12-31 2003-12-03 Wound dressing
CA2514080A Expired - Lifetime CA2514080C (en) 2002-12-31 2003-12-03 Wound dressing

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2510977A Expired - Lifetime CA2510977C (en) 2002-12-31 2003-12-03 Wound dressing comprising an absorbent core with a plurality of receptacles formed therein

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2514080A Expired - Lifetime CA2514080C (en) 2002-12-31 2003-12-03 Wound dressing

Country Status (8)

Country Link
US (16) US7423193B2 (en)
EP (3) EP1587554B1 (en)
JP (4) JP2006516003A (en)
AU (3) AU2003294366B2 (en)
CA (3) CA2510977C (en)
DK (1) DK1583493T3 (en)
ES (1) ES2543082T3 (en)
WO (3) WO2004060359A1 (en)

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