CA2515205C - Swab for collecting biological specimens - Google Patents
Swab for collecting biological specimens Download PDFInfo
- Publication number
- CA2515205C CA2515205C CA002515205A CA2515205A CA2515205C CA 2515205 C CA2515205 C CA 2515205C CA 002515205 A CA002515205 A CA 002515205A CA 2515205 A CA2515205 A CA 2515205A CA 2515205 C CA2515205 C CA 2515205C
- Authority
- CA
- Canada
- Prior art keywords
- fibre
- swab
- tip
- rod
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000835 fiber Substances 0.000 claims abstract description 48
- 238000010521 absorption reaction Methods 0.000 claims abstract description 5
- 239000001963 growth medium Substances 0.000 claims description 7
- 239000000853 adhesive Substances 0.000 claims description 6
- 230000001070 adhesive effect Effects 0.000 claims description 6
- 239000004952 Polyamide Substances 0.000 claims description 4
- 230000005686 electrostatic field Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 229920002647 polyamide Polymers 0.000 claims description 4
- 229920000728 polyester Polymers 0.000 claims description 4
- 229920000297 Rayon Polymers 0.000 claims description 3
- 239000002964 rayon Substances 0.000 claims description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 229920000742 Cotton Polymers 0.000 claims description 2
- 229940072056 alginate Drugs 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 238000004458 analytical method Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000012258 culturing Methods 0.000 description 2
- 244000144992 flock Species 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000001823 molecular biology technique Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/38—Swabs having a stick-type handle, e.g. cotton tips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5029—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures using swabs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/02—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by impregnation, e.g. using swabs or loops
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/08—Ergonomic or safety aspects of handling devices
- B01L2200/087—Ergonomic aspects
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
Abstract
The present invention relates to a swab (20) for collecting biological specimens of the type consisting of a rod (14) terminating in a tip (16) covered with fibre (17) with hydrophilic properties to allow absorption of said specimens, characterised in that said fibre (17) covers said tip (16) in the form of a layer deposited by flocking.
Description
SWAB FOR COLLECTING BIOLOGICAL SPECIMENS
Field of the invention The present invention relates to a swab for collecting biological specimens.
Background of the invention In the field of clinical and diagnostic analyses, svrabs for collecting biological specimens of organic material are known, consisting essentially of a cylindricail rod around one end of which, known as the tip, is wrapped a wad of fibre such as rayon or a natural fibre such as cotton, with hydrophilic properties to allow rapid absorption of the quantity of specimen to be collected and testrsd. Stable io adherence of the fibre wrapped around the tip of the rod is generally achieved by gluing.
Usually, especially if the specimen is to be examined by culturing the microorganisms gathered with the collection, a swab is immersed in a test-tube containing culture medium immediately after collection for appropriate conservation of the specimen during storage and /or transport thereof to the analytical laboratory. -An example of this type of device is given in patent EP0643131 by the same Applicant and refers to a swab for collecting and in vitro transporting specimens, of the type comprising a test-tube with culture medium in gel form and a rod carrying at one end a stopper for sealing the test-tube and at the opposite end means for collecting said specimen, for example a wad of fibre wrapped around the tip of the rod, to be dipped into the culture medium.
The tip of the cylindrical rod, generally manufactured from essentially rigid material such as plastic, for example by extrusion, commonly presents a truncating cut which would make it difficult to insert the swab rod into the cavities (oral, nasal, ocular or rectal, urethral, vaginal etc.) of the patient from whom the specimen is taken, if the tip is not adequately protected. Therefore, the wad of hydrophilic fibre wrapped around said truncated end must not only contain sufficient material to allow absorption of the specimen in the desired quantity, in general 100 microlitres, but must also have a sufficiently thick and rounded shape to sheathe the edge of the truncated end so that it cannot cause damage or irritation to the patient during specimen collection. For this reason the fibre wad is wrapped around the tip of the rod in a rounded shape, typically developing into an ogive or similar shape so that it gradually becomes thicker towards the end of the rod thus reaching maximum thickness and therefore maximum protective effect, precisely around the truncated end. A wad of such a shape, while protecting the patient from any risk of contact evith said truncated end of the rod, results in a nuniber of drawbacks. The main one is that the thickness of the wad, because of the hydrophilic nature of the fibre, leads to penetration of collected liquid specimen into the mass of said wad. As, for practical reasons, the sample is released from the swab at the moment of analysis by simply gripping the rod of the sevab and i delicately sliding its tip and hence the fibre impregnated with liquid, along for example a petri dish with culture medium, in practice by spreading the specimen onto this latter (swabbing), even if this operation is repeated and is careful, it does not enable the entire volume e.g. the 100 ml of absorbed specimen to be released, because that part of it which has penetrated into the interior of the wad in the direction of its tip cannot be pressed out towards the surface and hence released by the swab during this operation Due to this defect, on average only about 40% of the liquid specimen collected can in practice be recovered for analysis. Such loss of specimen translates inevitably into reduced sensitivity of analysis and increased false negatives.
In this respect, referring to the aforementioned average specimen loss after swabbing the swab, by testing only the 40 microlitres released for swabbing out of the 100 microlitres of specimen initially collected, it becomes difficult to establish whether a negative test effectively refers to the absence of the microorganism sought or rather to its non- or insufficient transfer from swab to test plate.
A further problem derived from the bulky fibre wad of a swab of the known art is particularly evident for example in the case of urethral or ocular use of said swab.
In these and other particular applications it would actually be even more desirable to be able to minimize swab thickness and hence patient discomfort during collection.
Summary of ths in~iantion As a solution to these problems, and also to achieve other advantages which will be apparent from the description, the present invention proposes a swab for collecting biological specimens of the type consisting of a rod terminating with a tip covered in fibre with hydrophilic properties to allow absorption of said specimens, characterised in that said fibre covers said tip in the form of a layer applied by means of flocking.
With the aim of better understanding the characteristics and advantages of the invention, a non-limiting example of a practical embodiment thereof is described hereinafter, with reference to the figures of the accompanying drawings. Said example refers to the case of a swab suitable for both the collection and storage of a biological specimen, and therefore also includes a test-tube containing a 1 culture medium suitable for the collected microorganisms into which the swab is to be immersed after collection, such as for example the type described in the aforementioned patent EP0643131 by the same Applicant.
Brief description of the figures Figure 1 shows an exploded view of the two components of a device in accordance with the example, that is the swab and test-tube, whereby the test-tube is partially sectioned longitudinally.
Figure 2 shows an enlarged detail of the swab of Figure 1 in section.
Detailed description of the invention With reference to said figures, a device of the invention in accordance with the illustrated example comprises an essentially cylindrical test-tube 10 containing a culture medium in gel form 11, presenting a free surface level 12 inside the test-tube.
The upper open end of the test-tube presents a collar 13 for receiving a closure means.
The device is completed by a swab 20 consisting of a rod 14 carrying at one end a stopper 15 which has to act as the closure means of the test-tube and is hence shaped so that it can engage, for example by snap-engaging, with the collar 13 of the test-tube.
At the opposite end, the rod 14 terminates with a tip 16 carrying a suitable means, for example a layer of fibre 17, for collecting the specimen to be analysed.
In the illustrated example, said tip 16 of the rod is shaped in a rounded geometry, similar to an ogive, and said fibre 17 being disposed as a layer of uniform thickness.
06/012CA descr.
Field of the invention The present invention relates to a swab for collecting biological specimens.
Background of the invention In the field of clinical and diagnostic analyses, svrabs for collecting biological specimens of organic material are known, consisting essentially of a cylindricail rod around one end of which, known as the tip, is wrapped a wad of fibre such as rayon or a natural fibre such as cotton, with hydrophilic properties to allow rapid absorption of the quantity of specimen to be collected and testrsd. Stable io adherence of the fibre wrapped around the tip of the rod is generally achieved by gluing.
Usually, especially if the specimen is to be examined by culturing the microorganisms gathered with the collection, a swab is immersed in a test-tube containing culture medium immediately after collection for appropriate conservation of the specimen during storage and /or transport thereof to the analytical laboratory. -An example of this type of device is given in patent EP0643131 by the same Applicant and refers to a swab for collecting and in vitro transporting specimens, of the type comprising a test-tube with culture medium in gel form and a rod carrying at one end a stopper for sealing the test-tube and at the opposite end means for collecting said specimen, for example a wad of fibre wrapped around the tip of the rod, to be dipped into the culture medium.
The tip of the cylindrical rod, generally manufactured from essentially rigid material such as plastic, for example by extrusion, commonly presents a truncating cut which would make it difficult to insert the swab rod into the cavities (oral, nasal, ocular or rectal, urethral, vaginal etc.) of the patient from whom the specimen is taken, if the tip is not adequately protected. Therefore, the wad of hydrophilic fibre wrapped around said truncated end must not only contain sufficient material to allow absorption of the specimen in the desired quantity, in general 100 microlitres, but must also have a sufficiently thick and rounded shape to sheathe the edge of the truncated end so that it cannot cause damage or irritation to the patient during specimen collection. For this reason the fibre wad is wrapped around the tip of the rod in a rounded shape, typically developing into an ogive or similar shape so that it gradually becomes thicker towards the end of the rod thus reaching maximum thickness and therefore maximum protective effect, precisely around the truncated end. A wad of such a shape, while protecting the patient from any risk of contact evith said truncated end of the rod, results in a nuniber of drawbacks. The main one is that the thickness of the wad, because of the hydrophilic nature of the fibre, leads to penetration of collected liquid specimen into the mass of said wad. As, for practical reasons, the sample is released from the swab at the moment of analysis by simply gripping the rod of the sevab and i delicately sliding its tip and hence the fibre impregnated with liquid, along for example a petri dish with culture medium, in practice by spreading the specimen onto this latter (swabbing), even if this operation is repeated and is careful, it does not enable the entire volume e.g. the 100 ml of absorbed specimen to be released, because that part of it which has penetrated into the interior of the wad in the direction of its tip cannot be pressed out towards the surface and hence released by the swab during this operation Due to this defect, on average only about 40% of the liquid specimen collected can in practice be recovered for analysis. Such loss of specimen translates inevitably into reduced sensitivity of analysis and increased false negatives.
In this respect, referring to the aforementioned average specimen loss after swabbing the swab, by testing only the 40 microlitres released for swabbing out of the 100 microlitres of specimen initially collected, it becomes difficult to establish whether a negative test effectively refers to the absence of the microorganism sought or rather to its non- or insufficient transfer from swab to test plate.
A further problem derived from the bulky fibre wad of a swab of the known art is particularly evident for example in the case of urethral or ocular use of said swab.
In these and other particular applications it would actually be even more desirable to be able to minimize swab thickness and hence patient discomfort during collection.
Summary of ths in~iantion As a solution to these problems, and also to achieve other advantages which will be apparent from the description, the present invention proposes a swab for collecting biological specimens of the type consisting of a rod terminating with a tip covered in fibre with hydrophilic properties to allow absorption of said specimens, characterised in that said fibre covers said tip in the form of a layer applied by means of flocking.
With the aim of better understanding the characteristics and advantages of the invention, a non-limiting example of a practical embodiment thereof is described hereinafter, with reference to the figures of the accompanying drawings. Said example refers to the case of a swab suitable for both the collection and storage of a biological specimen, and therefore also includes a test-tube containing a 1 culture medium suitable for the collected microorganisms into which the swab is to be immersed after collection, such as for example the type described in the aforementioned patent EP0643131 by the same Applicant.
Brief description of the figures Figure 1 shows an exploded view of the two components of a device in accordance with the example, that is the swab and test-tube, whereby the test-tube is partially sectioned longitudinally.
Figure 2 shows an enlarged detail of the swab of Figure 1 in section.
Detailed description of the invention With reference to said figures, a device of the invention in accordance with the illustrated example comprises an essentially cylindrical test-tube 10 containing a culture medium in gel form 11, presenting a free surface level 12 inside the test-tube.
The upper open end of the test-tube presents a collar 13 for receiving a closure means.
The device is completed by a swab 20 consisting of a rod 14 carrying at one end a stopper 15 which has to act as the closure means of the test-tube and is hence shaped so that it can engage, for example by snap-engaging, with the collar 13 of the test-tube.
At the opposite end, the rod 14 terminates with a tip 16 carrying a suitable means, for example a layer of fibre 17, for collecting the specimen to be analysed.
In the illustrated example, said tip 16 of the rod is shaped in a rounded geometry, similar to an ogive, and said fibre 17 being disposed as a layer of uniform thickness.
06/012CA descr.
In general terms, in accordance with the fundamental characteristic of the invention, said fibre with hydrophilic properties is deposited by means of flocking. The flocking technique is preferably of the type conducted in an electrostatic field which deposits the fibres in an ordered manner, perpendicular to the surface of the tip of the swab rod, which has been previously coated with adhesive for example by immersion or spraying.
The fibre which is to form the flocked layer is subjected to an electrostatic field, and is hence deposited in an oriented manner and anchored to the surface of the tip, being retained by the adhesive.
The adhesive is preferably water-based: once dried it enables the fibre to be anchored in a stable manner to the swab and to resist abrasion.
The flocked swab is then dried by exposing it to a source of heat or radio-frequency.
The tip of the swab stem is covered with a layer of fibre, preferably of uniform thickness, and from 0.6 mm to 3 mm thick. The fibre count, i.e. the weight in grams of a single fibre, is preferably between 1.7 Dtex and 3.3 Dtex, wherein Dtex means decitex, being a measure of weight for a single fibre/yarn such that 1 Dtex equals 1 gram per 10,000 meters. In particular, a fibre of 0.6 mm length and 1.7 Dtex can be applied by flocking to obtain a fine nap, and a fibre up to 3 mm in length and 3.3 Dtex can be applied to obtain a long nap, obtaining, for values intermediate between the aforedefined, corresponding intermediate characteristics of thickness and fineness of the flocked layer.
Within the wide choice of such values, the expedient to be respected according to the objects of the invention is to maintain an ordered arrangement of the fibres, substantially parallel to each other and normal to the surface of the rod, avoiding any overlapping of fibres which can occur if the nap is too long. Indeed, in this manner the capillary represented by each fibre, by virtue of which it can carry out its task of absorbing and releasing essentially the same quantity of specimen, remains unimpaired and functional.
The amount of fibre to be deposited for forming the flocked layer in accordance with the invention is determined on the basis of the type of fibre and the pre-chosen layer characteristics of thickness and fineness, in such a manner as to enable 100 microlitres of specimen to be absorbed.
In accordance with the objects of the invention, the fibre is chosen from a wide range of materials provided they are hydrophilic by capillarity, such as for example, synthetic or artificial materials e.g. rayon, polyester, polyamide, carbon fibre or alginate, natural materials e.g. c tdon and silk, or miad;ures thereof.
The fibre which is to form the flocked layer is subjected to an electrostatic field, and is hence deposited in an oriented manner and anchored to the surface of the tip, being retained by the adhesive.
The adhesive is preferably water-based: once dried it enables the fibre to be anchored in a stable manner to the swab and to resist abrasion.
The flocked swab is then dried by exposing it to a source of heat or radio-frequency.
The tip of the swab stem is covered with a layer of fibre, preferably of uniform thickness, and from 0.6 mm to 3 mm thick. The fibre count, i.e. the weight in grams of a single fibre, is preferably between 1.7 Dtex and 3.3 Dtex, wherein Dtex means decitex, being a measure of weight for a single fibre/yarn such that 1 Dtex equals 1 gram per 10,000 meters. In particular, a fibre of 0.6 mm length and 1.7 Dtex can be applied by flocking to obtain a fine nap, and a fibre up to 3 mm in length and 3.3 Dtex can be applied to obtain a long nap, obtaining, for values intermediate between the aforedefined, corresponding intermediate characteristics of thickness and fineness of the flocked layer.
Within the wide choice of such values, the expedient to be respected according to the objects of the invention is to maintain an ordered arrangement of the fibres, substantially parallel to each other and normal to the surface of the rod, avoiding any overlapping of fibres which can occur if the nap is too long. Indeed, in this manner the capillary represented by each fibre, by virtue of which it can carry out its task of absorbing and releasing essentially the same quantity of specimen, remains unimpaired and functional.
The amount of fibre to be deposited for forming the flocked layer in accordance with the invention is determined on the basis of the type of fibre and the pre-chosen layer characteristics of thickness and fineness, in such a manner as to enable 100 microlitres of specimen to be absorbed.
In accordance with the objects of the invention, the fibre is chosen from a wide range of materials provided they are hydrophilic by capillarity, such as for example, synthetic or artificial materials e.g. rayon, polyester, polyamide, carbon fibre or alginate, natural materials e.g. c tdon and silk, or miad;ures thereof.
5 E2~Ksmpisz Some preparative examples are nove given of a swab according to the invention.
Such examples are not intended in any way to limit the scope of the invention.
A swab is prepared using a plastic rod, suitable for human clinical collection, of i diameter 2.5 mm which decreases to 1 mm over a length of about 6 cm.
The tip of the part with the smallest diameter is dipped in or sprayed with an adhesive, then the rod is placed vertically in a flocking apparatus in electrostatic field to deposit a polyamide flock.
The polyamide flock of 0.7 mm length and 1.7 Dtex allows 0.5 pl per mm2 to be absorbed, therefore by flocking the 10 mm long tip of said rod the absorbing capacity obtained.is 40 pl.
Proceeding as per example 1, a rod with a spatulate end is used, suited for example to collecting organic specimens from the oral cavity of a patient.
Polyester fibre of 1 mm length and 1.7 Dtex count are used for the flocking.
Proceeding as per examples 1 and 2, polyester fibre of 2 mm length and 2.5 Dtex count is used.
Continuing in general terms, it is calculated that a swab of the invention is capable of releasing about 90% of the absorbed specimen by swabbing, in this manner considerably increasing the sensitivity of the analysis compared with swabs of the known art, in particular by almost completely eliminating the risk of false negatives resulting from the incomplete release of the collected specimen from swab to test plate.
In addition, the fact of being able to form, according to the invention, a fibre layer of any thickness, even very small, around the tip of the rod rather than a mass to cover it, as in the known art, means that the required rounded shape of the swab, i.e. free of edges, no longer has to depend on the mass of fibre itself but on the tip of the rod, which can therefore be preferably shaped into a round form, as indeed occurs in the aforedescribed example and shown in the accompanying drawings.
Particularly in specific cases where swabs of the greatest possible thinness are required, for eazample urethral or ocular, this represents a further definite advantage over known swabs. Indeed a swab csin be provided with a rounded tip by virtue of its shaping, around which a thin layer of fibre is deposited by flocking to allow on the one hand collection of a sufficient quantity of specimen for analysis, and on the other to minimize the total bulk of the part of the swab vehich lo is to penetrate the urethra, in consequence so reducing the discomfort of the patient undergoing the collection procedure.
The shape given to the tip of the swab nevertheless varies greatly according to the type of collection it is intended for, and can even be truncated or have edges when the type of collection (for example oral) allows it.
According to the invention, the type of adhesive, type of fibre and fibre characteristics, such as length and count, are in any case chosen from a wide range of options in order to obtain an ideal specific marker for identifying the microbiological specimen, whether by a direct diagnostic technique, by immuno-test, or by molecular biology techniques such as PCR, or with other known culturing, enrichment or selection techniques.
The specimen to be collected with a swab of the invention generally consists of bacteria or viruses or DNA or RNA or a mixture thereof.
Such examples are not intended in any way to limit the scope of the invention.
A swab is prepared using a plastic rod, suitable for human clinical collection, of i diameter 2.5 mm which decreases to 1 mm over a length of about 6 cm.
The tip of the part with the smallest diameter is dipped in or sprayed with an adhesive, then the rod is placed vertically in a flocking apparatus in electrostatic field to deposit a polyamide flock.
The polyamide flock of 0.7 mm length and 1.7 Dtex allows 0.5 pl per mm2 to be absorbed, therefore by flocking the 10 mm long tip of said rod the absorbing capacity obtained.is 40 pl.
Proceeding as per example 1, a rod with a spatulate end is used, suited for example to collecting organic specimens from the oral cavity of a patient.
Polyester fibre of 1 mm length and 1.7 Dtex count are used for the flocking.
Proceeding as per examples 1 and 2, polyester fibre of 2 mm length and 2.5 Dtex count is used.
Continuing in general terms, it is calculated that a swab of the invention is capable of releasing about 90% of the absorbed specimen by swabbing, in this manner considerably increasing the sensitivity of the analysis compared with swabs of the known art, in particular by almost completely eliminating the risk of false negatives resulting from the incomplete release of the collected specimen from swab to test plate.
In addition, the fact of being able to form, according to the invention, a fibre layer of any thickness, even very small, around the tip of the rod rather than a mass to cover it, as in the known art, means that the required rounded shape of the swab, i.e. free of edges, no longer has to depend on the mass of fibre itself but on the tip of the rod, which can therefore be preferably shaped into a round form, as indeed occurs in the aforedescribed example and shown in the accompanying drawings.
Particularly in specific cases where swabs of the greatest possible thinness are required, for eazample urethral or ocular, this represents a further definite advantage over known swabs. Indeed a swab csin be provided with a rounded tip by virtue of its shaping, around which a thin layer of fibre is deposited by flocking to allow on the one hand collection of a sufficient quantity of specimen for analysis, and on the other to minimize the total bulk of the part of the swab vehich lo is to penetrate the urethra, in consequence so reducing the discomfort of the patient undergoing the collection procedure.
The shape given to the tip of the swab nevertheless varies greatly according to the type of collection it is intended for, and can even be truncated or have edges when the type of collection (for example oral) allows it.
According to the invention, the type of adhesive, type of fibre and fibre characteristics, such as length and count, are in any case chosen from a wide range of options in order to obtain an ideal specific marker for identifying the microbiological specimen, whether by a direct diagnostic technique, by immuno-test, or by molecular biology techniques such as PCR, or with other known culturing, enrichment or selection techniques.
The specimen to be collected with a swab of the invention generally consists of bacteria or viruses or DNA or RNA or a mixture thereof.
Claims (9)
1. Swab (20) for collecting biological specimens of the type comprising a rod (14) terminating in a tip (16) covered with fibre (17) with hydrophilic properties to allow absorption of said specimens, characterised in that said fibre (17) covers said tip (16) in the form of a layer deposited by flocking whereby said layer of flocked fibre is capable of absorbing and releasing substantially the same quantity of specimen.
2. Swab as claimed in claim 1, characterised in that said rod tip (16) is shaped with a rounded geometry, such as an ogive, said fibre (17) being arranged in a uniform thickness.
3. Swab as claimed in claim 1, characterised in that said rod tip (16) is shaped with a geometry at least partly truncated or with edges.
4. Swab as claimed in claim 1, characterised in that said layer of said fibre (17) has a thickness between 0.6 mm and 3 mm.
5. Swab as claimed in claim 1, characterised in that in said fibre layer (17), said fibre has a count between 1.7 Dtex and 3.3 Dtex.
6. Swab as claimed in claim 1, characterised in that in said layer (17), said fibre has a length and count variable from respectively 0.6 mm and 1.7 Dtex to provide a fine nap, to a length of 3 mm and a count of 3.3 Dtex to provide a long nap.
7. Swab as claimed in claim 1, characterised In that said fibre (17) is chosen from rayon, polyester, polyamide, carbon fibre, alginate; natural fibres such as cotton and silk; or their mixtures.
8. Device for collecting and transporting biological specimens characterised by comprising a test-tube (10) containing a culture medium (11), and a swab (20) as claimed in one or more of claims 1, 2, 3, 4, 5, 6, and 7.
9. Method for preparing a swab (20) as claimed in one or more of claims 1, 2, 3, 4, 5, 6, and 7 characterised by comprising the steps of applying an adhesive to the tip (16) of said rod (14) of said swab (20) to be covered by fibre (17), and subjecting said swab (20) to flocking with the pre-selected fibre (17) in an electrostatic field.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000643A ITMI20030643A1 (en) | 2003-04-01 | 2003-04-01 | BUFFER FOR THE COLLECTION OF BIOLOGICAL SAMPLES |
ITMI2003A000643 | 2003-04-01 | ||
PCT/EP2004/003392 WO2004086979A1 (en) | 2003-04-01 | 2004-03-31 | Swab for collecting biological specimens |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2515205A1 CA2515205A1 (en) | 2004-10-14 |
CA2515205C true CA2515205C (en) | 2007-07-17 |
Family
ID=33105040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002515205A Expired - Lifetime CA2515205C (en) | 2003-04-01 | 2004-03-31 | Swab for collecting biological specimens |
Country Status (10)
Country | Link |
---|---|
US (9) | US8114027B2 (en) |
EP (1) | EP1608268B2 (en) |
JP (1) | JP4579902B2 (en) |
CA (1) | CA2515205C (en) |
DE (6) | DE202004021787U1 (en) |
DK (1) | DK1608268T4 (en) |
ES (1) | ES2297406T5 (en) |
IT (1) | ITMI20030643A1 (en) |
NZ (1) | NZ541560A (en) |
WO (1) | WO2004086979A1 (en) |
Families Citing this family (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2533915C (en) | 2002-08-13 | 2020-09-22 | N-Dia, Inc. | Devices and methods for detecting amniotic fluid in vaginal secretions |
ITMI20030643A1 (en) * | 2003-04-01 | 2004-10-02 | Copan Innovation Ltd | BUFFER FOR THE COLLECTION OF BIOLOGICAL SAMPLES |
WO2005049809A1 (en) | 2003-11-18 | 2005-06-02 | Charm Sciences, Inc. | Inhibition assay method and device for detection of antibiotics |
WO2006069053A2 (en) | 2004-12-22 | 2006-06-29 | Charm Sciences, Inc. | Sampling method and device |
PL1844189T3 (en) * | 2005-01-10 | 2021-10-25 | Smiths Detection Inc. | Method for preparing a sampling swab |
WO2006131423A1 (en) * | 2005-06-08 | 2006-12-14 | Copan Innovation Limited | Device for the withdrawal, collection and transport of specimens for diagnostic analyses |
ITMI20051057A1 (en) * | 2005-06-08 | 2006-12-09 | Copan Innovation Ltd | DEVELOPMENT, COLLECTION AND TRANSPORT OF BIOLOGICAL SAMPLES |
US8476064B2 (en) | 2006-05-09 | 2013-07-02 | Charm Sciences, Inc. | Inhibition assay method and device for detection of antibiotics |
US7749173B2 (en) * | 2006-06-01 | 2010-07-06 | Daniel Larkin | Apparatus for simultaneously collecting exocervical and endocervical samples |
US8323211B2 (en) * | 2006-06-01 | 2012-12-04 | Daniel Larkin | Sexually transmitted infection sampling device |
US8439847B2 (en) * | 2006-06-01 | 2013-05-14 | Daniel Larkin | Method and apparatus for simultaneously collecting exocervical and endocervical samples |
US20110270127A1 (en) * | 2006-09-18 | 2011-11-03 | Shany Vered | Biological Fluid Receptacle |
JP4339906B2 (en) * | 2006-10-19 | 2009-10-07 | デンカ生研株式会社 | Simple membrane assay method and kit using sample filtration filter |
JP5586842B2 (en) * | 2006-10-19 | 2014-09-10 | デンカ生研株式会社 | Simple membrane assay method and kit using sample filtration filter |
WO2009017188A1 (en) * | 2007-08-01 | 2009-02-05 | Nipro Corporation | Stress measurement kit and stress measurement method |
EP2060900A3 (en) * | 2007-11-13 | 2009-10-07 | Mayo Foundation for Medical Education and Research | Biopsy sample mount and processing method |
US20090163933A1 (en) * | 2007-12-20 | 2009-06-25 | John DiMaio | Cold Wax Ear Hair Removal Instrument |
EP2250479A2 (en) * | 2008-02-15 | 2010-11-17 | 3M Innovative Properties Company | Sample acquisition device |
EP2254480A1 (en) * | 2008-02-15 | 2010-12-01 | 3M Innovative Properties Company | Sample acquisition device |
US20110244248A1 (en) * | 2008-12-11 | 2011-10-06 | Liu ying jun | Coating and a method of coating |
US8348856B1 (en) | 2008-12-16 | 2013-01-08 | Zanetta Malanowska-Stega | Simultaneous multiple method out-patient uterus biopsy device and method |
WO2010126614A2 (en) | 2009-04-30 | 2010-11-04 | Good Start Genetics, Inc. | Methods and compositions for evaluating genetic markers |
JP5290131B2 (en) * | 2009-11-16 | 2013-09-18 | デンカ生研株式会社 | Swab for collecting biological specimen, method for producing the swab, and kit using the swab |
US8420385B2 (en) | 2010-04-21 | 2013-04-16 | Puritan Medical Products Company, Llc | Collection device and material |
EP2381258A1 (en) | 2010-04-26 | 2011-10-26 | Securetec Detektions-Systeme AG | Microfluidic system with sample pre-treatment |
ITMI20100796A1 (en) * | 2010-05-06 | 2011-11-07 | Copan Italia Spa | DEVELOPMENT AND TRANSFER OF A SAMPLE OF BIOLOGICAL MATERIAL |
JP2011234666A (en) * | 2010-05-10 | 2011-11-24 | Sanyo:Kk | Swab |
IT1401447B1 (en) * | 2010-06-09 | 2013-07-26 | Copan Italia Spa | METHOD FOR THE QUANTITATIVE TRANSFER OF ANALYTES |
DE202010010203U1 (en) | 2010-07-14 | 2010-11-04 | Helling Gmbh | Swabs for collection and sterile storage of biological samples |
US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
IT1403618B1 (en) * | 2011-01-05 | 2013-10-31 | Copan Italia Spa | PROCEDURE FOR REALIZING A DEVICE FOR THE COLLECTION AND TRANSFER OF SAMPLES FOR MOLECULAR BIOLOGY |
WO2015067913A1 (en) | 2013-11-07 | 2015-05-14 | Diagnodus Limited | Biomarkers |
GB201107466D0 (en) * | 2011-05-05 | 2011-06-15 | Loktionov Alexandre | Device and method for non-invasive collection of colorectal mucocellular layer and disease detection |
ITUD20110129A1 (en) | 2011-08-10 | 2013-02-11 | Alifax Holding S P A | DEVICE FOR THE COLLECTION OF BIOLOGICAL SAMPLES, AND ITS PROCEDURE |
US9228233B2 (en) | 2011-10-17 | 2016-01-05 | Good Start Genetics, Inc. | Analysis methods |
US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
DE202012101720U1 (en) | 2012-05-10 | 2012-06-06 | Nathanael Riess | Swabs and containers for collection and sterile storage of biological samples |
ITMI20121120A1 (en) | 2012-06-26 | 2013-12-27 | Copan Italia Spa | DEVICE AND METHOD FOR THE COLLECTION, TRANSFER AND / OR CONSERVATION OF SAMPLES OF BIOLOGICAL MATERIAL |
JP6257614B2 (en) | 2012-07-06 | 2018-01-10 | スリーエム イノベイティブ プロパティズ カンパニー | Apparatus for detecting ATP in a liquid sample |
WO2014007846A1 (en) | 2012-07-06 | 2014-01-09 | 3M Innovative Properties Company | Apparatus and methods for detecting atp in a liquid sample |
US10519434B2 (en) | 2012-07-13 | 2019-12-31 | Diomics Corporation | Biologic sample collection devices and methods of production and use thereof |
US9708600B2 (en) | 2012-07-13 | 2017-07-18 | Diomics Corporation | Biologic sample collection devices and methods of production and use thereof |
ITMI20121603A1 (en) * | 2012-09-25 | 2014-03-26 | Copan Italia Spa | DEVICE AND METHOD FOR THE COLLECTION AND TRANSFER OF SAMPLES OF BIOLOGICAL MATERIAL |
US10537703B2 (en) * | 2012-11-26 | 2020-01-21 | Thync Global, Inc. | Systems and methods for transdermal electrical stimulation to improve sleep |
CN105008925B (en) | 2013-01-02 | 2017-09-26 | N-Dia有限责任公司 | The method for predicting the pregnant woman childbirth time |
US20160008632A1 (en) * | 2013-02-22 | 2016-01-14 | Thync, Inc. | Methods and apparatuses for networking neuromodulation of a group of individuals |
JP5686853B2 (en) * | 2013-06-13 | 2015-03-18 | デンカ生研株式会社 | Swab for collecting biological specimen, method for producing the swab, and kit using the swab |
ITMI20131088A1 (en) * | 2013-06-28 | 2014-12-29 | Copan Italia Spa | FLOCKED BUFFER AND METHOD FOR THE COLLECTION AND TRANSFER OF SAMPLES OF BIOLOGICAL MATERIAL |
ITMI20131673A1 (en) | 2013-10-10 | 2015-04-11 | Copan Italia Spa | FLOCKED BUFFER FOR THE COLLECTION AND TRANSFER OF SAMPLES OF BIOLOGICAL MATERIAL AND RELATIVE PRODUCTION METHOD |
US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
US9243222B2 (en) * | 2014-01-06 | 2016-01-26 | Lawrence Livermore National Security, Llc | Compositions and methods for pathogen transport |
USD788908S1 (en) * | 2014-03-14 | 2017-06-06 | Khaled W. Abusaif | Swab |
WO2015187849A2 (en) | 2014-06-04 | 2015-12-10 | Lucigen Corporation | Sample collection and analysis devices |
WO2016025021A1 (en) | 2014-08-15 | 2016-02-18 | Diomics Corporation | Films for biologic analyte collection and analysis and methods of production and use thereof |
WO2016040446A1 (en) | 2014-09-10 | 2016-03-17 | Good Start Genetics, Inc. | Methods for selectively suppressing non-target sequences |
US10429399B2 (en) | 2014-09-24 | 2019-10-01 | Good Start Genetics, Inc. | Process control for increased robustness of genetic assays |
EP4095261A1 (en) | 2015-01-06 | 2022-11-30 | Molecular Loop Biosciences, Inc. | Screening for structural variants |
JP6664157B2 (en) * | 2015-07-03 | 2020-03-13 | 株式会社クラレ | Mucus collection device from nasal cavity or throat |
WO2017027538A1 (en) * | 2015-08-11 | 2017-02-16 | Stem Arts Projects, Llc | Portable nucleic acid extraction apparatus and method of using the same |
ITUB20153258A1 (en) | 2015-08-27 | 2017-02-27 | Copan Italia Spa | Device for the collection, transfer and storage of biological and / or chemical material samples |
US9995756B2 (en) | 2015-10-01 | 2018-06-12 | Beth Israel Deaconess Medical Center, Inc. | Buccal cell diagnosis of arrhythmogenic cardiomyopathy (ACM) |
US20170100574A1 (en) * | 2015-10-09 | 2017-04-13 | Edward Tak Wei | Apparatus configured for accurate up-loading of a single dose onto a delivery applicator |
US10980520B2 (en) | 2015-10-19 | 2021-04-20 | Green Panther, LLC | Urine sampling vessel |
ITUB20155324A1 (en) | 2015-11-03 | 2017-05-03 | Copan Italia Spa | Device for the collection, transfer and storage of biological and / or chemical material samples |
WO2017210748A1 (en) * | 2016-06-10 | 2017-12-14 | Flinders University Of South Australia | Nucleic acid collection device and method |
DE102016007658A1 (en) * | 2016-06-23 | 2017-12-28 | Interbros Gmbh | Interdental cleaners |
EP3329991A1 (en) | 2016-12-02 | 2018-06-06 | Securetec Detektions-Systeme AG | Drug detection via surface enhanced raman spectroscopy |
WO2018107175A1 (en) | 2016-12-09 | 2018-06-14 | Malanowska Stega Zanetta | Brush biopsy device, kit and method |
US10935555B2 (en) | 2016-12-22 | 2021-03-02 | Qiagen Sciences, Llc | Determining candidate for induction of labor |
US10656164B2 (en) * | 2016-12-22 | 2020-05-19 | Qiagen Sciences, Llc | Screening asymptomatic pregnant woman for preterm birth |
KR20190122220A (en) | 2017-02-17 | 2019-10-29 | 포렉스 코포레이션 | Liquid applicators and devices |
US11291986B2 (en) | 2017-02-24 | 2022-04-05 | Becton, Dickinson And Company | Unique sample transfer device for an automated pipettor for processing a variety of clinical microbiological specimens |
RU2680930C2 (en) * | 2017-03-24 | 2019-02-28 | федеральное государственное бюджетное образовательное учреждение высшего образования "Северный государственный медицинский университет" Министерства здравоохранения Российской Федерации | Method of material reconstruction for cytological research during tumor diseases of the pancreas, liver and bile duct |
WO2019118550A1 (en) | 2017-12-13 | 2019-06-20 | Gen-Probe Incorporated | Methods for biological sample processing |
GB2572359A (en) * | 2018-03-27 | 2019-10-02 | Ge Healthcare Uk Ltd | Method and device for collecting, preserving and transferring samples |
EP3989840A1 (en) | 2019-06-28 | 2022-05-04 | Universiteit Gent | Sampling device for biological specimen |
US20230098565A1 (en) | 2020-01-31 | 2023-03-30 | Western Connecticut Health Network, Inc. | Apparatus and method for collecting liquid samples |
US20210290210A1 (en) * | 2020-03-20 | 2021-09-23 | University Of South Florida | Three-dimensional printed swabs for diagnostic testing |
WO2021214029A1 (en) | 2020-04-20 | 2021-10-28 | Dsm Ip Assets B.V. | Swab |
US20210330299A1 (en) * | 2020-04-23 | 2021-10-28 | Rodon Limited Partnership | Medical Swab |
DE102020116824B3 (en) | 2020-05-14 | 2021-07-15 | Vinceni Property Ii Gmbh | Swabs for collecting biological samples |
IT202000011683A1 (en) | 2020-05-20 | 2021-11-20 | Vacutest Kima S R L | SWAB FOR COLLECTING BIOLOGICAL SAMPLES AND METHOD FOR MAKING SUCH SWAB |
EP4163397A1 (en) * | 2020-06-05 | 2023-04-12 | Seegene, Inc. | Specimen transport kit for detecting respiratory pathogens and methods for detecting respiratory pathogens using same |
DE202020103402U1 (en) | 2020-06-15 | 2020-06-18 | Walter Schmidt | Swab for removing secretions from or from a human or animal body |
EP3932553A1 (en) | 2020-06-29 | 2022-01-05 | Erber Aktiengesellschaft | Container for small liquid volumes |
WO2022020260A1 (en) | 2020-07-20 | 2022-01-27 | Stratix Labs Corporation | Methods and articles for testing disinfectant and sanitizer efficacy |
CZ309621B6 (en) * | 2020-08-31 | 2023-05-24 | Isolit-Bravo, spol. s r.o | A swab |
USD982158S1 (en) | 2020-09-21 | 2023-03-28 | Vectornate Usa Inc. | Swab for collecting biological samples |
USD975271S1 (en) | 2020-09-21 | 2023-01-10 | Vectornate Korea Co., Ltd. | Swab for collecting biological samples |
DE102020212866A1 (en) | 2020-10-12 | 2022-06-23 | Christof-Herbert Diener | Plasma treated cleaning and/or swab swab |
USD975270S1 (en) | 2020-11-06 | 2023-01-10 | Yukon Medical, Llc | Culture swab |
KR102445778B1 (en) * | 2020-12-10 | 2022-09-20 | 최기범 | Virus sample collection rod manufacturing device for diagnostic kit |
KR102445776B1 (en) * | 2020-12-10 | 2022-09-20 | 최기범 | Method for manufacturing virus sample collection rod for diagnostic kit |
WO2022167498A1 (en) | 2021-02-02 | 2022-08-11 | Universiteit Leiden | Mass-spectrometric method for pathogen detection |
USD972130S1 (en) | 2021-02-18 | 2022-12-06 | University Of South Florida | Swab |
AU2022237386A1 (en) | 2021-03-15 | 2023-10-05 | Gen-Probe Incorporated | Compositions and methods for biological sample processing |
WO2022195328A1 (en) * | 2021-03-18 | 2022-09-22 | Chaffringeon Bernard Marie | Breakable swab applicator for use with a sampling cloth and a swab kit |
KR102586214B1 (en) * | 2021-03-23 | 2023-10-12 | 아이비에스메디칼 주식회사 | A surgical shaft |
USD977089S1 (en) | 2021-04-23 | 2023-01-31 | Carnegie Mellon University | Swab |
USD977091S1 (en) | 2021-04-23 | 2023-01-31 | Carnegie Mellon University | Swab |
USD977090S1 (en) | 2021-04-23 | 2023-01-31 | Carnegie Mellon University | Swab |
KR102602612B1 (en) * | 2021-06-10 | 2023-11-16 | 주식회사 더웨이브톡 | Container for sample transport medium |
JP7157939B1 (en) | 2021-06-23 | 2022-10-21 | 株式会社西浦化学 | specimen collection swab |
CN116448494A (en) | 2022-01-10 | 2023-07-18 | 浙江东方基因生物制品股份有限公司 | Apparatus for producing collector for collecting sample |
KR102490103B1 (en) * | 2022-02-28 | 2023-01-20 | 피엠더블유 주식회사 | Swab for collecting sample and method for preparing thereof |
CA3167468A1 (en) | 2022-03-15 | 2023-09-15 | Zhejiang Orient Gene Biotech Co., Ltd. | Device for detecting an analyte in a liquid sample |
CN117168866A (en) | 2022-05-27 | 2023-12-05 | 杭州博拓生物科技股份有限公司 | Sample collector |
CN117423095A (en) | 2022-07-18 | 2024-01-19 | 浙江东方基因生物制品股份有限公司 | Automatic identification method, device and equipment for detection result of immunoreagent card |
Family Cites Families (168)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2034986A (en) | 1932-01-02 | 1936-03-24 | Mislowitzer Ernst | Device for dispatching swabs, blood samples, and the like for bacteriological and diagnostic purposes |
US3163160A (en) * | 1962-11-15 | 1964-12-29 | Milton J Cohen | Disposable swab and culture medium device |
US3434801A (en) | 1964-02-21 | 1969-03-25 | Colab Lab Inc | Diagnostic test material for determination of ovulatory function and method for production of said test material |
US3776753A (en) | 1971-04-30 | 1973-12-04 | Deering Milliken Res Corp | Synthetic suede fabrics |
CA983358A (en) | 1971-09-08 | 1976-02-10 | Kenneth D. Bagshawe | Performance of chemical or biological reactions |
US3954563A (en) | 1971-10-29 | 1976-05-04 | Mennen Frederick C | Apparatus especially useful for detection of neisseria gonorrhoeae and the like in females |
GB1408140A (en) | 1971-12-09 | 1975-10-01 | Levene M M | Sampling device |
US3792699A (en) | 1972-05-30 | 1974-02-19 | Medex Inc | Disposable swab unit |
US3854319A (en) | 1972-10-16 | 1974-12-17 | Borg Warner | Alcoholic breath simulator |
US3744499A (en) * | 1972-10-30 | 1973-07-10 | R Wells | Dental floss roll comprising interconnected pieces each having a pick end |
DE2255454C3 (en) | 1972-11-11 | 1979-07-12 | Bayer Ag, 5090 Leverkusen | Heavy-duty sandwich body |
US4039934A (en) * | 1973-12-07 | 1977-08-02 | Fedor Ivanovich Ostashko | Method of and apparatus for measuring ionic electric conductance of objects |
US4175560A (en) | 1975-11-21 | 1979-11-27 | Paul Hartmann Ag | Swab |
DE2552172C3 (en) | 1975-11-21 | 1980-09-04 | Ernst 7801 Umkirch Knoll | Swabs, in particular for medical purposes |
US4030978A (en) | 1976-07-29 | 1977-06-21 | Becton, Dickinson And Company | Novel assembly, compositions and methods |
DE2755341C2 (en) | 1977-12-12 | 1983-09-08 | Akzo Gmbh, 5600 Wuppertal | Hydrophilic polyester fibers |
US4227537A (en) | 1978-03-08 | 1980-10-14 | Tucson Medical Instruments, Inc. | Endometrial brush with slidable protective sleeve |
US4196167A (en) | 1978-12-26 | 1980-04-01 | California Medical Developments, Inc. | Drug detection device |
JPS55121301U (en) * | 1979-02-22 | 1980-08-28 | ||
US4234316A (en) | 1979-04-02 | 1980-11-18 | Fmc Corporation | Device for delivering measured quantities of reagents into assay medium |
US4454109A (en) | 1981-02-17 | 1984-06-12 | Forsyth Dental Infirmary For Children | Method of treating periodontosis |
US4340670A (en) | 1981-06-19 | 1982-07-20 | Mennen Frederick C | Method of using over the counter swab kit for self detection of gonorrhea in the male using tetramethyl chromogen ampul |
US4421809A (en) | 1982-09-20 | 1983-12-20 | The Procter & Gamble Company | Floor mat with flock fibers adhesively bonded onto a thin polymeric film |
US4525452A (en) | 1983-01-24 | 1985-06-25 | Btc Diagnostics Limited Partnership | Enzyme immunoassay with step of immersing sample in deionized water |
DE3305798A1 (en) | 1983-02-19 | 1984-08-23 | Akzo Gmbh, 5600 Wuppertal | METHOD FOR PRODUCING HYDROPHILIC POLYESTER FIBERS |
US5279964A (en) | 1984-01-10 | 1994-01-18 | Chrisope Technologies, Inc. | Storable inoculation device containing stabilized microorganisms |
US4579376A (en) | 1984-03-14 | 1986-04-01 | Security Engineering, Inc. | Fail-secure and fail-safe door lock mechanism |
WO1985005296A1 (en) * | 1984-05-18 | 1985-12-05 | Berkshire Corporation | Swab for cleanroom environment |
US4759376A (en) | 1984-05-29 | 1988-07-26 | Nils Stormby | Endocervical sampling brush and smear method |
SE455262B (en) | 1984-10-01 | 1988-07-04 | Leif Einar Stern | SET TO MAKE BRUSHES FOR CLEANING BAKERY-LOADED SURFACES, PREFERRED TO CLEAN SKIN, DENTAL OR TENDERS, AND BRUSH MADE IN THIS SET |
US4734964A (en) | 1985-10-24 | 1988-04-05 | Cooper Lasersonics, Inc. | Apparatus for refurbishing acoustic members |
US4877037A (en) * | 1985-11-12 | 1989-10-31 | Minnesota Mining And Manufacturing Company | Tissue or mucus sampling device |
IT8505253A0 (en) | 1985-11-15 | 1985-11-15 | Copan Srl | SWAB WITH TANK OF TRANSPORT MEDIA FOR COLLECTING AND TRANSFERRING SAMPLES OF SUBSTANCES TO BE ANALYZED INTO TEST. |
US4719181A (en) * | 1985-12-20 | 1988-01-12 | Warner-Lambert Company | Free flowing granular indicator material for peroxidase-like activity |
US5468606A (en) | 1989-09-18 | 1995-11-21 | Biostar, Inc. | Devices for detection of an analyte based upon light interference |
JPS62231081A (en) * | 1986-04-01 | 1987-10-09 | 東レ株式会社 | Staple fiber for electric flocking |
US4767398A (en) | 1986-04-25 | 1988-08-30 | Chesebrough-Pond's Inc. | Swab applicator comprising a flock swab tip |
DE3619033A1 (en) | 1986-06-06 | 1987-12-10 | Bayer Ag | METHOD FOR PRODUCING FLOCK |
CH681137A5 (en) * | 1986-08-14 | 1993-01-29 | Saxer Ulrich P | |
FR2603780B1 (en) | 1986-09-15 | 1988-12-02 | Oreal | APPLICATOR ASSEMBLY OF A LIQUID, PASTY OR POWDERED PRODUCT SUCH AS A COSMETIC PRODUCT |
US4707450A (en) | 1986-09-25 | 1987-11-17 | Nason Frederic L | Specimen collection and test unit |
US4789639A (en) | 1987-01-02 | 1988-12-06 | Becton, Dickinson And Company | Liquid recovery device |
US4873992A (en) | 1987-03-20 | 1989-10-17 | Medical Dynamics, Inc. | Cervical cytology device |
US4754764A (en) | 1987-03-20 | 1988-07-05 | Medical Dynamics, Inc. | Cervical cytology device |
US4749655A (en) * | 1987-06-01 | 1988-06-07 | Becton Dickinson And Company | Specimen collection package |
US4877036A (en) | 1987-10-13 | 1989-10-31 | Saint Amand Elmer F | Swab transport system |
US5370992A (en) | 1992-03-18 | 1994-12-06 | Amoco Corporation | Nucleic acid probes and methods for detecting Yersinia enterocolitica |
US4856136A (en) | 1988-05-06 | 1989-08-15 | Padco, Inc. | Flocked foam brush |
SE463188B (en) | 1988-05-10 | 1990-10-22 | Stormby Nils | BRUSH FOR MEDICAL SAMPLING |
US5623941A (en) | 1988-05-10 | 1997-04-29 | Nils Stormby | Cervical sampling velour brush |
US5163441A (en) | 1988-06-09 | 1992-11-17 | Becton, Dickinson And Company | Polyurethane biological sample collection and transport device and its use |
FR2633256B1 (en) | 1988-06-23 | 1990-09-21 | Oreal | ASSEMBLY COMPRISING A TANK CONTAINING A LIQUID AND AN APPLICATOR HAVING A FLEXIBLE DISPENSING NOZZLE |
JPH0527671Y2 (en) | 1988-07-20 | 1993-07-14 | ||
FR2637687B1 (en) | 1988-10-11 | 1991-01-11 | Inst Textile De France | SINGLE USE DEVICE FOR BIOLOGICAL TESTS |
US5460781A (en) * | 1989-10-27 | 1995-10-24 | Fujirebio Kabushiki Kaisha | Hemoglobin sampler |
US4953560A (en) | 1989-12-07 | 1990-09-04 | Bernard Samuels | Apparatus, method, and test kit for diagnosis of vaginal yeast infections |
US5022408A (en) * | 1990-04-23 | 1991-06-11 | Mohajer Reza S | Combination exo/endocervical sampler |
SE465451B (en) | 1990-05-10 | 1991-09-16 | Medscand Ab | INSTRUMENTS FOR ENDO- AND ECTOCERVIC SAMPLING |
US5091153A (en) * | 1990-10-11 | 1992-02-25 | Toxi-Lab Incorporated | Chemical analysis test device |
JPH06504963A (en) | 1991-01-22 | 1994-06-09 | コレス・ホールディング・ツーク・アクチェンゲゼルシャフト | Correction fluid applicator |
FR2679113B1 (en) | 1991-07-19 | 1994-06-17 | Oreal | APPLICATOR ASSEMBLY FOR LIQUID COMPOSITION, ESPECIALLY COSMETIC. |
JPH0527671A (en) | 1991-07-20 | 1993-02-05 | Takeshi Oriide | Waxprinting |
US5418136A (en) | 1991-10-01 | 1995-05-23 | Biostar, Inc. | Devices for detection of an analyte based upon light interference |
CN1022673C (en) | 1992-09-03 | 1993-11-10 | 刘福元 | Method and equipment for electrostatic flocking in ambient temp. |
FR2708937B1 (en) | 1993-08-09 | 1995-12-08 | Sanofi Elf | DNA sequence and plasmids comprising at least one mechanism of resistance to phages, bacteria containing them and their use. |
IT1272598B (en) | 1993-09-09 | 1997-06-26 | Copan Italia Spa | DEVICE FOR THE COLLECTION AND TRANSPORT OF SAMPLES IN VITRO MAINLY FOR DIAGNOSTIC USE |
CN2183735Y (en) | 1993-12-08 | 1994-11-30 | 梅兹坎得·Ab | Sampling tool |
US5614375A (en) | 1994-03-23 | 1997-03-25 | Yissum Research Development Co. Of The Hebrew University Of Jerusalem | Method and test kit for the rapid detection of biotoxic contaminants |
US5538732A (en) | 1994-04-12 | 1996-07-23 | Creative Products Resource, Inc. | Medicated applicator sheet for topical drug delivery |
FR2729545A1 (en) * | 1994-06-06 | 1996-07-26 | Geraut Roland | Book or box of matches and toothpicks |
FR2722381B1 (en) | 1994-07-12 | 1997-02-28 | Oreal | APPLICATOR FOR THE APPLICATION OF A LIQUID PRODUCT AND MAKE-UP KIT EQUIPPED WITH SUCH AN APPLICATOR |
US6328159B1 (en) * | 1994-07-13 | 2001-12-11 | Centrix, Inc | Single patient dose medicament dispenser with applicator |
SE9403459L (en) * | 1994-10-12 | 1995-11-27 | Leif Einar Stern | Toothpicks and process for making them |
US5676643A (en) | 1995-02-13 | 1997-10-14 | The Procter & Gamble Company | Dispenser for friably releasing dry particulate medicaments |
JPH11514849A (en) | 1995-07-12 | 1999-12-21 | チャーム サイエンシズ インコーポレイテッド | Inspection apparatus, system and method for detecting an inspection sample |
DE69715691T2 (en) * | 1996-01-18 | 2003-07-31 | John Stephen Griffiths | Oral hygiene device |
US5738643A (en) * | 1996-04-02 | 1998-04-14 | Stredic, Iii; Prince-Allen | Swab |
US5710041A (en) | 1996-06-03 | 1998-01-20 | Remel L.P. | In situ reconstitutable lyophylized bacteria ampoule package |
JPH1024065A (en) * | 1996-07-12 | 1998-01-27 | Sanritsu Kk | Cotton swab |
FR2752696B1 (en) | 1996-09-02 | 1998-09-25 | Oreal | LIQUID OR SEMI-LIQUID APPLICATOR AND APPLICATION ASSEMBLY USING SUCH AN APPLICATOR |
JP3323085B2 (en) | 1996-09-11 | 2002-09-09 | 株式会社山洋 | Medical swabs |
US5704388A (en) * | 1996-09-27 | 1998-01-06 | Freeman; Roger | Tubular toothpick having a feathered tip |
US6420181B1 (en) | 1996-12-11 | 2002-07-16 | The United States Of America As Represented By The Secretary Of The Army | Field microspot test method for on-site chemical testing |
JPH10192050A (en) | 1996-12-27 | 1998-07-28 | Kao Corp | Pen type lip cosmetic |
JP3373385B2 (en) * | 1997-03-06 | 2003-02-04 | 富士通株式会社 | Frequency modulation method and modem device |
ATE493139T1 (en) | 1997-04-18 | 2011-01-15 | Ganeden Biotech Inc | SURFACE USE OF PROBIOTIC BACILLUS SPORES TO PREVENT OR CONTROL MICROBIAL INFECTIONS |
DE19729623B4 (en) | 1997-07-10 | 2004-10-07 | Mettler-Toledo Gmbh | Arrangement for fastening a parallelogram guide in a force measuring device |
US6049934A (en) | 1997-09-22 | 2000-04-18 | Centrix, Inc. | Disposable dental applicator |
US6634051B1 (en) | 1997-09-22 | 2003-10-21 | Centrix, Inc. | Disposable dental applicator |
US5846215A (en) | 1997-12-11 | 1998-12-08 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Antibacterial swabs |
US6306498B1 (en) | 1997-12-22 | 2001-10-23 | Asahi Kasei Kabushiki Kaisha | Fibers for electric flocking and electrically flocked article |
US5869003A (en) * | 1998-04-15 | 1999-02-09 | Nason; Frederic L. | Self contained diagnostic test unit |
US6451607B1 (en) | 1998-05-07 | 2002-09-17 | Litmus Concepts, Inc. | External dried-reagent control for analytical test devices |
US6010462A (en) | 1998-05-28 | 2000-01-04 | Becton Dickinson And Company | Blister style culture transport device and method for using the same |
US6080126A (en) | 1998-08-14 | 2000-06-27 | Chesebrough-Pond's Usa Co., Divison Of Conopco, Inc. | Cotton swabs with soft tips |
KR19980082053A (en) * | 1998-08-17 | 1998-11-25 | 정혁 | Structure of cervical cancer screening brush |
JP3478738B2 (en) | 1998-09-03 | 2003-12-15 | 憲司 中村 | Cosmetic applicator and manufacturing method thereof |
US20010008614A1 (en) | 1998-11-16 | 2001-07-19 | Jack L. Aronowitz | Sample collection system and method of use thereof |
JP2000232982A (en) | 1999-01-12 | 2000-08-29 | Genelink Inc | Noninvasive identification system |
AUPP915799A0 (en) | 1999-03-11 | 1999-04-15 | Enterix Inc. | Sample collection and testing system |
JP4372888B2 (en) | 1999-06-01 | 2009-11-25 | 栄研化学株式会社 | Sample collection instrument set |
EP1235518A1 (en) | 1999-06-25 | 2002-09-04 | Ampersand Medical Corporation | Personal cervical cell collector |
US6497688B2 (en) | 1999-07-19 | 2002-12-24 | Mcneil-Ppc, Inc. | Absorbent article comprising flocked fibers |
US6732743B1 (en) | 1999-07-22 | 2004-05-11 | Color Access, Inc. | Flocked cosmetic applicator |
US6625839B2 (en) | 2000-01-18 | 2003-09-30 | Ultradent Products, Inc. | Flocked tongue cleaning device |
US6286246B1 (en) | 2000-02-01 | 2001-09-11 | Ultradent Products, Inc. | Electrostatically flocked fishing lures and related systems and methods |
US6413087B1 (en) | 2000-02-24 | 2002-07-02 | 3M Innovative Properties Company | Packaged applicator assembly |
US6365794B1 (en) | 2000-03-22 | 2002-04-02 | Mcneil-Ppc, Inc. | Microporous films comprising flocked fibers |
US6548018B2 (en) | 2000-03-31 | 2003-04-15 | Neogen Corporation | Apparatus for chemiluminescent assays |
US6541194B2 (en) * | 2000-03-31 | 2003-04-01 | Neogen Corporation | Method for the detection of the presence of chemical species known to inhibit a chemiluminescent reaction |
FR2809182B1 (en) * | 2000-05-18 | 2003-08-15 | Univ Rene Descartes | DETECTION OF IL-6 FOR PREDICTING PREMATURE DELIVERY RISKS |
JP2002067201A (en) | 2000-06-09 | 2002-03-05 | Korumosu:Kk | Flocked material and decorative sheet as well as its manufacturing method |
JP2001346626A (en) | 2000-06-09 | 2001-12-18 | Fumie Taidou | Make up set for eyelash decoration |
US6376025B1 (en) | 2000-09-14 | 2002-04-23 | Phillip Mark | Method and system for applying minute bristles to a flow through applicator |
CA2358813A1 (en) | 2000-10-13 | 2002-04-13 | Pedinol Pharmacal, Inc. | Method for applying a medicament and swab applicator for uses therewith |
US6450810B1 (en) | 2000-10-30 | 2002-09-17 | Ultradent Products, Inc. | Cushioned, fiber-covered dental applicators |
US6382972B1 (en) | 2000-10-30 | 2002-05-07 | Ultradent Products, Inc. | Cushioned, fiber-covered dental delivery tips |
CN2460050Y (en) | 2001-01-18 | 2001-11-21 | 江苏苏云医疗器材有限公司 | Medical sampling swab |
CN2479505Y (en) | 2001-03-30 | 2002-02-27 | 王佑雄 | Microbial teting box |
US6916626B1 (en) | 2001-04-25 | 2005-07-12 | Rockeby Biomed Ltd. | Detection of Candida |
US6494845B2 (en) | 2001-05-04 | 2002-12-17 | Oralscan Laboratories, Inc. | Retractable brush for use with endoscope for brush biopsy |
CA2449925C (en) | 2001-06-08 | 2010-03-09 | F. Hoffmann-La Roche Ag | Control solution packets and methods for calibrating bodily fluid sampling devices |
JP4642277B2 (en) | 2001-06-21 | 2011-03-02 | 株式会社ジーシー | Saliva pretreatment tool and saliva pretreatment method |
US6638067B2 (en) | 2001-09-04 | 2003-10-28 | Ultradent Products, Inc. | Flocked endodontic files and other flocked devices |
US20030073932A1 (en) | 2001-09-05 | 2003-04-17 | Mark Varey | Body fluid sample preparation |
US6494856B1 (en) | 2001-09-12 | 2002-12-17 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Swab deliverable actives |
US7022289B1 (en) | 2001-10-10 | 2006-04-04 | The United States Of America As Represented By The Secretary Of The Army | Chemical and biological sampling device and kit and method of use thereof |
US20050101841A9 (en) | 2001-12-04 | 2005-05-12 | Kimberly-Clark Worldwide, Inc. | Healthcare networks with biosensors |
US20030108846A1 (en) | 2001-12-06 | 2003-06-12 | Kimberly-Clark Worldwide, Inc. | Disposable oral hygiene device and methods of making same |
US20030120180A1 (en) | 2001-12-21 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Method and apparatus for collecting and testing biological samples |
US7261483B2 (en) | 2002-04-30 | 2007-08-28 | L'ORéAL S.A. | Device, system, and method for applying a product |
FR2838936B1 (en) | 2002-04-30 | 2004-12-24 | Oreal | DEVICE FOR APPLYING A PRODUCT, ESPECIALLY COSMETIC, COVERED WITH A FLOCK OF DIFFERENT TYPES OF FIBERS |
EP1382730A1 (en) | 2002-07-15 | 2004-01-21 | Paul Hartmann AG | Cosmetic cotton pad |
CN2554995Y (en) | 2002-08-05 | 2003-06-11 | 宁波美生医疗器材有限公司 | Sampler for uterine cervix |
US20040158188A1 (en) | 2002-10-01 | 2004-08-12 | L'oreal | Analyte-taking device |
DE10246379B4 (en) | 2002-10-04 | 2005-12-22 | Jenner, Günter | Process for the preparation of a flocked cosmetic applicator head |
US6929475B1 (en) | 2002-10-04 | 2005-08-16 | Centrix, Inc. | Pre-dosed applicator and applicator system |
USD489535S1 (en) | 2002-11-02 | 2004-05-11 | Centrix, Inc. | Disposable flocked applicator |
PL377477A1 (en) | 2002-12-11 | 2006-02-06 | Ferrosan A/S | Gelatine-based materials as swabs |
US7198623B2 (en) * | 2003-01-10 | 2007-04-03 | Ultradent Products, Inc. | Fiber-coated dental infusor systems and methods of use |
ITMI20030643A1 (en) | 2003-04-01 | 2004-10-02 | Copan Innovation Ltd | BUFFER FOR THE COLLECTION OF BIOLOGICAL SAMPLES |
US6957958B2 (en) | 2003-04-02 | 2005-10-25 | Centrix, Inc. | Unit dose applicator with material chamber |
FR2857567B1 (en) | 2003-07-17 | 2006-11-24 | Oreal | PACKAGING ASSEMBLY OF A HAIR COLORING PRODUCT AND TEST DEVICE CAPABLE OF BEING USED IN SUCH ASSEMBLY |
US20050256440A1 (en) | 2004-04-30 | 2005-11-17 | Zunker Maryann | Disposable device for mechanically engaging a vagina |
US20050288616A1 (en) | 2004-06-28 | 2005-12-29 | Smiths Detection, Inc. | Sampling swab |
US7645608B2 (en) | 2004-08-17 | 2010-01-12 | Pml Microbiologicals, Inc. | Microorganism specimen storage, hydrating, transfer and applicator device |
US8445293B2 (en) | 2005-02-09 | 2013-05-21 | Rapid Pathogen Screening, Inc. | Method to increase specificity and/or accuracy of lateral flow immunoassays |
US20070105186A1 (en) | 2005-02-09 | 2007-05-10 | Gibson Berman C | Method for preserving microbial cells |
US7582067B2 (en) | 2005-03-15 | 2009-09-01 | Ted Gerard Van Acker | Prepared medication applicator including a swab and a pharmacological active agent |
US20070141562A1 (en) | 2005-12-15 | 2007-06-21 | Grove Thomas H | Apparatus and methods for high yield microbial surface sampling |
JP5478074B2 (en) | 2006-02-23 | 2014-04-23 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | Removable antimicrobial coating composition and method of use |
US7915032B2 (en) | 2006-03-03 | 2011-03-29 | Capitol Vial Inc. | Sample collection system and method |
EP2007651A4 (en) | 2006-04-14 | 2012-09-05 | Bode Technology Group Inc | Low pressure sample collection apparatus |
US8439847B2 (en) | 2006-06-01 | 2013-05-14 | Daniel Larkin | Method and apparatus for simultaneously collecting exocervical and endocervical samples |
WO2008027904A2 (en) | 2006-08-28 | 2008-03-06 | Rexaderm, Inc. | Dry wound dressing and drug delivery system |
US8652782B2 (en) | 2006-09-12 | 2014-02-18 | Longhorn Vaccines & Diagnostics, Llc | Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids |
CN101765551A (en) | 2007-04-16 | 2010-06-30 | 奥瑞许科技有限公司 | Sample divider |
US20090030341A1 (en) | 2007-07-27 | 2009-01-29 | 3M Innovative Properties Company | Sample release system |
WO2009018607A1 (en) | 2007-08-03 | 2009-02-12 | Polartechnics Limited | Device and method for biological sampling |
CN201131761Y (en) | 2007-10-21 | 2008-10-15 | 张金花 | Cervices sampler |
EP2250479A2 (en) | 2008-02-15 | 2010-11-17 | 3M Innovative Properties Company | Sample acquisition device |
WO2009136892A1 (en) | 2008-05-09 | 2009-11-12 | Akonni Biosystems | Microarray system |
GB0808557D0 (en) | 2008-05-13 | 2008-06-18 | 3M Innovative Properties Co | Sampling devices and methods of use |
US8337108B2 (en) | 2008-06-26 | 2012-12-25 | Elc Management Llc | Single-use cosmetic sampler |
IT1401447B1 (en) | 2010-06-09 | 2013-07-26 | Copan Italia Spa | METHOD FOR THE QUANTITATIVE TRANSFER OF ANALYTES |
CN201993241U (en) | 2010-12-24 | 2011-09-28 | 江苏世泰实验器材有限公司 | Quantitative biological sampling flocked swab |
IT1403618B1 (en) | 2011-01-05 | 2013-10-31 | Copan Italia Spa | PROCEDURE FOR REALIZING A DEVICE FOR THE COLLECTION AND TRANSFER OF SAMPLES FOR MOLECULAR BIOLOGY |
ITMI20121603A1 (en) | 2012-09-25 | 2014-03-26 | Copan Italia Spa | DEVICE AND METHOD FOR THE COLLECTION AND TRANSFER OF SAMPLES OF BIOLOGICAL MATERIAL |
-
2003
- 2003-04-01 IT IT000643A patent/ITMI20030643A1/en unknown
-
2004
- 2004-03-31 DE DE202004021787U patent/DE202004021787U1/en not_active Ceased
- 2004-03-31 DE DE602004010240.7T patent/DE602004010240T3/en not_active Expired - Lifetime
- 2004-03-31 EP EP04724556.8A patent/EP1608268B2/en not_active Expired - Lifetime
- 2004-03-31 JP JP2006504927A patent/JP4579902B2/en not_active Expired - Lifetime
- 2004-03-31 ES ES04724556T patent/ES2297406T5/en not_active Expired - Lifetime
- 2004-03-31 DE DE202004021907U patent/DE202004021907U1/en not_active Expired - Lifetime
- 2004-03-31 NZ NZ541560A patent/NZ541560A/en active Application Revival
- 2004-03-31 DE DE202004021932U patent/DE202004021932U1/en not_active Ceased
- 2004-03-31 WO PCT/EP2004/003392 patent/WO2004086979A1/en active IP Right Grant
- 2004-03-31 DE DE202004021930U patent/DE202004021930U1/en not_active Ceased
- 2004-03-31 US US10/543,873 patent/US8114027B2/en not_active Expired - Lifetime
- 2004-03-31 CA CA002515205A patent/CA2515205C/en not_active Expired - Lifetime
- 2004-03-31 DK DK04724556.8T patent/DK1608268T4/en active
- 2004-03-31 DE DE202004021908U patent/DE202004021908U1/en not_active Expired - Lifetime
-
2010
- 2010-10-13 US US12/903,921 patent/US8317728B2/en not_active Expired - Lifetime
-
2012
- 2012-01-30 US US13/361,584 patent/US8979784B2/en active Active
- 2012-06-25 US US13/531,800 patent/US9011358B2/en active Active
- 2012-10-23 US US13/657,949 patent/US11364018B2/en not_active Expired - Lifetime
-
2013
- 2013-05-21 US US13/899,394 patent/US9173779B2/en not_active Expired - Lifetime
-
2015
- 2015-09-18 US US14/858,792 patent/US10327741B2/en active Active
-
2019
- 2019-06-21 US US16/448,398 patent/US20190307433A1/en active Pending
-
2022
- 2022-05-13 US US17/744,421 patent/US11446012B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11446012B2 (en) | Swab for collecting biological specimens | |
US9170177B2 (en) | Device and a method for collecting and transferring samples of biological material | |
US9428788B2 (en) | Method for quantitative transfer of analytes | |
US10517575B2 (en) | Flocked swab and method for collection and transfer of samples of biological material | |
AU2004226798B2 (en) | Swab for collecting biological specimens | |
CN101103931B (en) | Device containing absorbent stuffing used for collecting clinical diagnose analyzing sample | |
KR20110051090A (en) | Device comprising a layer of absorbent material for collecting samples for clinical and diagnostic analyses |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |