CA2516490A1 - Measuring apparatus for determining an analyte in a liquid sample - Google Patents

Measuring apparatus for determining an analyte in a liquid sample Download PDF

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Publication number
CA2516490A1
CA2516490A1 CA002516490A CA2516490A CA2516490A1 CA 2516490 A1 CA2516490 A1 CA 2516490A1 CA 002516490 A CA002516490 A CA 002516490A CA 2516490 A CA2516490 A CA 2516490A CA 2516490 A1 CA2516490 A1 CA 2516490A1
Authority
CA
Canada
Prior art keywords
measuring apparatus
test
detector
selection circuit
analyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002516490A
Other languages
French (fr)
Other versions
CA2516490C (en
Inventor
Wolfgang Clemens
Axel Gerlt
Bernd Roesicke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2516490A1 publication Critical patent/CA2516490A1/en
Application granted granted Critical
Publication of CA2516490C publication Critical patent/CA2516490C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15105—Purely manual piercing, i.e. the user pierces the skin without the assistance of any driving means or driving devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142—Devices intended for single use, i.e. disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48785—Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0295—Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157

Abstract

A measuring apparatus used for determining an analyte in a liquid sample has the following apparatus components: a test element with a test field for applying the liquid sample, the test element experiencing a detectable modification due to the analyte to be determined, a detector which detects the modification and generates an electrical detector signal as a function of it, an evaluation circuit arranged downstream of the detector, which evaluates the detector signal to form a measurement result, a display device connected to the evaluation circuit for displaying the measurement result, and an electrical power supply for supplying electrical power to the electrical apparatus components.
So that the analyte can be determined in a straightforwardly, conveniently and inexpensively, at least some of the electrical apparatus components (5 to 12) are formed on the basis of polymer electronics.

Claims (17)

1. A measuring apparatus for determining an analyte in a liquid sample, having the following apparatus components: a test element (4) with a test field (2) for applying the liquid sample, the test element (4) experiencing a detectable modification due to the analyte to be determined, a detector (5) which detects the modification and generates an electrical detector signal as a function of it, an evaluation circuit (6) arranged downstream of the detector (5), which evaluates the detector signal to form a measurement result, a display device (7) connected to the evaluation circuit (6) for displaying the measurement result, and an electrical power supply (10) for supplying electrical power to the electrical apparatus components (5 to 8), characterized in that at least some of the electrical apparatus components (5 to 10) are formed on the basis of polymer electronics.
2. The measuring apparatus as claimed in claim 1, characterized in that the electrical apparatus components (2 to 10) are formed on a flat support (1).
3. The measuring apparatus as claimed in claim 1, characterized in that the test field (2) and the test element (4) or the test field (2), the test element (4) and the detector (5) are formed in a first apparatus unit (14), which can be coupled via an interface (15, 16) to a further apparatus unit (support 1) which contains the other apparatus components (6 to 10).
4. The measuring apparatus as claimed in one of the preceding claims, characterized in that the apparatus components furthermore comprise a controller (8) which controls the determination of the analyte in a measurement process.
5. The measuring apparatus as claimed in claim 4, characterized in that the controller (8) has means for activating the measurement process, which respond to at least one of the following events: an operating element (9) on the measuring apparatus is actuated, a cover on the measuring apparatus is removed, the test element (4) is coupled to the card-shaped support (1), the liquid sample is applied onto the test field (2).
6. The measuring apparatus as claimed in claim 4 or 5, characterized in that the controller (8) has means for preventing further measurement processes with the same test element (4).
7. The measuring apparatus as claimed in claim 6, characterized in that there are display means, in particular the display device (7), which can be driven by the controller (8) in order to display that the measuring apparatus is unusable.
8. The measuring apparatus as claimed in one of the preceding claims, characterized in that the evaluation circuit (6) has a calibration data memory (36) with calibrations data for correcting the measurement results to be displayed.
9. The measuring apparatus as claimed in one of the preceding claims, characterized in that the measuring apparatus has at least one removable cover (21), in particular packaging, at least in the region of the test field (2), which seals against environmental effects, in particular water vapor and/or oxygen.
10. The measuring apparatus as claimed in one of the preceding claims, characterized in that the electrical power supply (10) is a chargeable storage capacitor (12).
11. The measuring apparatus as claimed in one of the preceding claims, characterized in that a pricking aid (13, 13', 13 " ), in particular a needle or a spike, is integrated in it in order to obtain blood as the liquid sample.
12. The measuring apparatus as claimed in one of the preceding claims, characterized in that at least one further test element (17) with a test field (18) and a detector (19) is provided, in that the detectors (5, 19) are connected via a selection circuit (20) to the evaluation circuit (6) and in that the selection circuit (20) always selects only one of the detectors (5, 19) and joins it only for single use to the selection circuit (20) and subsequently selects an as yet unused detector after the measurement has taken place.
13. The measuring apparatus as claimed in claim 12, characterized in that the selection circuit (20) drives display means, in particular the display device (7), so that it displays the test field assigned to the currently usable detector.
14. The measuring apparatus as claimed in claim 12 or 13, characterized in that the test fields (2, 18) are respectively covered with a cover (21, 24) to be removed before use, in that detection means (22) joined to the selection circuit (20) are arranged in the regions of the covers (21', 24, 28) and in that the selection circuit (20) detects covers (21', 24, 28) having been removed.
15. The measuring apparatus as claimed in one of claims 12 to 14, characterized in that when the apparatus components are formed on a flat support (1), the test fields (2, 18) are arranged in the edge region of the support (1) in zones (26) separated from one another by break lines (27) and in that each zone (26) can be broken off from the support (1) after the test field lying in it has been used.
16. The measuring apparatus as claimed in claim 15, characterized in that the test fields (2, 18) in the zones (26) are arranged so that they are respectively covered by a neighboring zone and are accessible only after this neighboring zone has been broken off.
17. The measuring apparatus as claimed in claim 15 or 16, characterized in that detection means joined to the selection circuit (20) are arranged in the regions of the break lines (27) and in that the selection circuit (20) detects zones having been broken off.
CA2516490A 2002-11-14 2003-11-14 Measuring apparatus for determining an analyte in a liquid sample Expired - Fee Related CA2516490C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10253154.4 2002-11-14
DE10253154A DE10253154A1 (en) 2002-11-14 2002-11-14 Biosensor, used to identify analyte in liquid sample, has test field with detector, where detector registers field changes as electrical signals for evaluation
PCT/DE2003/003784 WO2004044571A1 (en) 2002-11-14 2003-11-14 Measuring apparatus used for determining an analyte in a liquid sample, comprising polymer electronic components

Publications (2)

Publication Number Publication Date
CA2516490A1 true CA2516490A1 (en) 2004-05-27
CA2516490C CA2516490C (en) 2011-10-11

Family

ID=32185677

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2516490A Expired - Fee Related CA2516490C (en) 2002-11-14 2003-11-14 Measuring apparatus for determining an analyte in a liquid sample

Country Status (10)

Country Link
US (1) US7641857B2 (en)
EP (1) EP1563288B1 (en)
JP (1) JP4808968B2 (en)
CN (1) CN1739024A (en)
AT (1) ATE480767T1 (en)
AU (1) AU2003294625A1 (en)
CA (1) CA2516490C (en)
DE (3) DE10253154A1 (en)
HK (1) HK1078134A1 (en)
WO (1) WO2004044571A1 (en)

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US7641857B2 (en) 2010-01-05
CN1739024A (en) 2006-02-22
US20060121625A1 (en) 2006-06-08
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AU2003294625A1 (en) 2004-06-03
AU2003294625A8 (en) 2004-06-03

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