CA2518769A1 - Apparatus and process for dose-guided radiotherapy - Google Patents
Apparatus and process for dose-guided radiotherapy Download PDFInfo
- Publication number
- CA2518769A1 CA2518769A1 CA002518769A CA2518769A CA2518769A1 CA 2518769 A1 CA2518769 A1 CA 2518769A1 CA 002518769 A CA002518769 A CA 002518769A CA 2518769 A CA2518769 A CA 2518769A CA 2518769 A1 CA2518769 A1 CA 2518769A1
- Authority
- CA
- Canada
- Prior art keywords
- patient
- radiation
- radiotherapy
- dose
- identified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1071—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan
- A61N2005/1072—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan taking into account movement of the target
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1071—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan
Abstract
A method and an apparatus for dose-guided radiotherapy for a patient (P) having an identified radiotherapy target utilizes a radiation detecting array (R) of radiation-sensitive dosimeters for the real-time remote measurement of radiotherapy at the radiation detecting array (R). The radiation detecting array is positioned within the patient's (P) body along the treatment path before or after the identified radiotherapy target or the device may be positioned beyond the patient (P) to measure transit dose. A radiation source (A) for emitting radiation for radiotherapy along a treatment path through the patient (P) to the identified radiotherapy target is utilized. The method includes generating a predicted dose pattern of radiation at the placed radiation detecting array (R). The predicted dose pattern assumes an on-target radiation source (A) emitting the radiotherapy beam along the treatment path through the patient (P) to the identified radiotherapy target. Gating of the radiation source (A) can occur responsive to the comparing of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array (R). Radiation intensity can vary between low levels to a treatment level responsive to coincidence of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array (R).
Claims (19)
1. A method of dose-guided radiotherapy for a patient having an identified radiotherapy target comprising the steps of:
providing a radiation detecting array of radiation-sensitive detectors for the remote measurement of real-tune dose pattern at the radiation detecting array;
providing a radiation source for emitting radiation along a treatment path through the patient to the identified radiotherapy target;
placing the radiation detecting array within the patient along the treatment path before or after the identified radiotherapy target or exterior to the patient's body on the treatment path;
generating a predicted dose pattern of radiation at the placed radiation detecting array;
emitting radiation along the treatment path through the patient's body to the array to receive the real-time dose pattern; and, comparing the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array to determine coincidence of radiation with the identified radiotherapy target in the patient.
providing a radiation detecting array of radiation-sensitive detectors for the remote measurement of real-tune dose pattern at the radiation detecting array;
providing a radiation source for emitting radiation along a treatment path through the patient to the identified radiotherapy target;
placing the radiation detecting array within the patient along the treatment path before or after the identified radiotherapy target or exterior to the patient's body on the treatment path;
generating a predicted dose pattern of radiation at the placed radiation detecting array;
emitting radiation along the treatment path through the patient's body to the array to receive the real-time dose pattern; and, comparing the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array to determine coincidence of radiation with the identified radiotherapy target in the patient.
2. The method of dose-guided radiotherapy for a patient having an identified radiotherapy target according to claim 1 and wherein:
placing the radiation detecting array adjacent to the identified radiotherapy target within the patient.
placing the radiation detecting array adjacent to the identified radiotherapy target within the patient.
3. The method of dose-guided radiotherapy for a patient having an identified radiotherapy target according to claim 1 and wherein:
placing the radiation detecting array exterior of the patient.
placing the radiation detecting array exterior of the patient.
4. The method of dose-guided radiotherapy for a patient having an identified radiotherapy target according to claim 1 and wherein:
gating the radiation source responsive to the comparing of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array.
gating the radiation source responsive to the comparing of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array.
5. The method of dose-guided radiotherapy for a patient having an identified radiotherapy target according to claim 4 and wherein:
gating the radiation source to a treatment level responsive to coincidence of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array.
gating the radiation source to a treatment level responsive to coincidence of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array.
6. The method of dose-guided radiotherapy for a patient having an identified radiotherapy target according to claim 4 and wherein:
gating the radiation source to a low level per unit of time responsive to non-coincidence of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array.
gating the radiation source to a low level per unit of time responsive to non-coincidence of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array.
7. The method of dose-guided radiotherapy for a patient having an identified radiotherapy target according to claim 1 and wherein:
moving the provided radiation source and patient relative to one another responsive to the comparing of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array to produce coincidence of the predicted dose pattern to the real-time dose pattern at the detecting array.
moving the provided radiation source and patient relative to one another responsive to the comparing of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array to produce coincidence of the predicted dose pattern to the real-time dose pattern at the detecting array.
8. The method of dose-guided radiotherapy for a patient having an identified radiotherapy target according to claim 6 and wherein:
utilizing the real-time dose pattern produced by the radiation source at the low level per unit of time to move the patient and accelerator into a position of coincidence between the predicted dose pattern and the real-time dose pattern measured at the array.
utilizing the real-time dose pattern produced by the radiation source at the low level per unit of time to move the patient and accelerator into a position of coincidence between the predicted dose pattern and the real-time dose pattern measured at the array.
9. The method that of dose-guided radiotherapy for a patient having an identified radiotherapy target according to claim 1 and wherein the step of placing the radiation detecting array exterior to the patient's body on the treatment path includes:
filling a pad with tissue equivalent gel;
placing the array with in the tissue equivalent gel; and, contacting pad with the patient to enable the pad with tissue equivalent gel to constitute a continuum of the patient's body.
filling a pad with tissue equivalent gel;
placing the array with in the tissue equivalent gel; and, contacting pad with the patient to enable the pad with tissue equivalent gel to constitute a continuum of the patient's body.
10. In the combination of, a patient having an identified radiotherapy target; and, a radiation source for emitting radiation along a treatment path through the patient to an identified radiotherapy target;
the improvement comprising:
a detecting array of radiation-sensitive dosimeters for the real-time dose measurement of radiation within the patient along the treatment path before or after the identified radiotherapy target or exterior to the patient's body on the treatment path.
the improvement comprising:
a detecting array of radiation-sensitive dosimeters for the real-time dose measurement of radiation within the patient along the treatment path before or after the identified radiotherapy target or exterior to the patient's body on the treatment path.
11. The combination of claim 10 and wherein:
the detecting array is placed outside of the patient.
the detecting array is placed outside of the patient.
12. The combination of claim 10 and wherein:
the detecting array is placed inside of the patient.
the detecting array is placed inside of the patient.
13. The combination of claim 10 and further including:
a memory for retaining a predicted dose pattern of the radiation source at the detecting array; and, means for detecting coincidence between the predicted dose pattern and the real-time dose pattern to enable alignment of the radiation source with respect to a patient.
a memory for retaining a predicted dose pattern of the radiation source at the detecting array; and, means for detecting coincidence between the predicted dose pattern and the real-time dose pattern to enable alignment of the radiation source with respect to a patient.
14. The combination of claim 11 and wherein:
the detecting array is placed with in a gel; and, the gel is confined with in a pad for direct contact with the patient.
the detecting array is placed with in a gel; and, the gel is confined with in a pad for direct contact with the patient.
15. The method of dose-guided radiotherapy for a patient having an identified radiotherapy target according to claim 1 and wherein:
the detector array is positioned in the patient's rectum adjacent to the prostate gland.
the detector array is positioned in the patient's rectum adjacent to the prostate gland.
16. The method of dose-guided radiotherapy for a patient having an identified radiotherapy target according to claim 15 and wherein:
the detector array is disposed in an inflatable rectal probe that stabilizes the position of the prostate gland and prevents the prostate gland from moving during the radiotherapy procedure.
the detector array is disposed in an inflatable rectal probe that stabilizes the position of the prostate gland and prevents the prostate gland from moving during the radiotherapy procedure.
17. The method of dose-guided radiotherapy for a patient having an identified radiotherapy target according to claim 15 and wherein:
the rectal probe contains an ultrasound probe to position the detector array with respect to the prostate gland.
the rectal probe contains an ultrasound probe to position the detector array with respect to the prostate gland.
18. The method of dose-guided radiotherapy for a patient having an identified radiotherapy target according to claim 15 and wherein:
the rectal probe includes a drug delivery compartment to supply radiation mitigating drugs.
the rectal probe includes a drug delivery compartment to supply radiation mitigating drugs.
19. The method of dose-guided radiotherapy for a patient having an identified radiotherapy target according to claim 15 and wherein:
the rectal probe includes a drug delivery sampling port to monitor drug density during the radiotherapy procedure.
the rectal probe includes a drug delivery sampling port to monitor drug density during the radiotherapy procedure.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45393403P | 2003-03-11 | 2003-03-11 | |
| US60/453,934 | 2003-03-11 | ||
| PCT/US2004/006905 WO2004080522A1 (en) | 2003-03-11 | 2004-03-04 | Apparatus and process for dose-guided radiotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2518769A1 true CA2518769A1 (en) | 2004-09-23 |
| CA2518769C CA2518769C (en) | 2012-07-17 |
Family
ID=32990839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2518769A Expired - Fee Related CA2518769C (en) | 2003-03-11 | 2004-03-04 | Apparatus and process for dose-guided radiotherapy |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7554090B2 (en) |
| EP (1) | EP1608427B1 (en) |
| AT (1) | ATE528039T1 (en) |
| AU (1) | AU2004220539B8 (en) |
| CA (1) | CA2518769C (en) |
| WO (1) | WO2004080522A1 (en) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2478296A1 (en) | 2002-03-06 | 2003-09-18 | Tomotherapy Incorporated | Method for modification of radiotherapy treatment delivery |
| US7158754B2 (en) * | 2003-07-01 | 2007-01-02 | Ge Medical Systems Global Technology Company, Llc | Electromagnetic tracking system and method using a single-coil transmitter |
| EP2532386A3 (en) | 2005-07-22 | 2013-02-20 | TomoTherapy, Inc. | System for delivering radiation therapy to a moving region of interest |
| KR20080039920A (en) * | 2005-07-22 | 2008-05-07 | 토모테라피 인코포레이티드 | System and method of evaluating dose delivered by a radiation therapy system |
| EP1907057B1 (en) | 2005-07-23 | 2017-01-25 | TomoTherapy, Inc. | Radiation therapy delivery device utilizing coordinated motion of gantry and couch |
| SE0502594L (en) * | 2005-11-28 | 2007-05-29 | Micropos Medical Ab | A device for measuring administered dose in a target range |
| JP5241714B2 (en) | 2006-07-07 | 2013-07-17 | プロテウス デジタル ヘルス， インコーポレイテッド | Smart parenteral delivery system |
| WO2008086434A2 (en) * | 2007-01-09 | 2008-07-17 | Cyberheart, Inc. | Depositing radiation in heart muscle under ultrasound guidance |
| WO2008086430A1 (en) * | 2007-01-09 | 2008-07-17 | Cyberheart, Inc. | Method for depositing radiation in heart muscle |
| US8500771B2 (en) * | 2007-01-16 | 2013-08-06 | Radiadyne, Llc | Rectal balloon apparatus with pressure relieving lumen and sensors |
| US20140336441A1 (en) * | 2007-01-16 | 2014-11-13 | Radiadyne Llc | Endorectal balloon with gas release lumen |
| US9381334B2 (en) | 2007-01-16 | 2016-07-05 | Radiadyne Llc | Endorectal balloon with gas release lumen |
| US9707379B2 (en) | 2007-01-16 | 2017-07-18 | Radiadyne Llc | Rectal balloon with locking stopper |
| US7831016B2 (en) * | 2007-03-01 | 2010-11-09 | Best Medical Canada | Radiation dosimetry apparatus and method, and dosimeter for use therein |
| US8509383B2 (en) | 2007-10-25 | 2013-08-13 | Tomotherapy Incorporated | System and method for motion adaptive optimization for radiation therapy delivery |
| WO2009055733A1 (en) | 2007-10-25 | 2009-04-30 | Proteus Biomedical, Inc. | Fluid transfer port information system |
| US8467497B2 (en) | 2007-10-25 | 2013-06-18 | Tomotherapy Incorporated | System and method for motion adaptive optimization for radiation therapy delivery |
| WO2009067463A1 (en) | 2007-11-19 | 2009-05-28 | Proteus Biomedical, Inc. | Body-associated fluid transport structure evaluation devices |
| US8238516B2 (en) * | 2008-01-09 | 2012-08-07 | Kabushiki Kaisha Toshiba | Radiotherapy support apparatus |
| JP2010054309A (en) * | 2008-08-27 | 2010-03-11 | Mitsubishi Heavy Ind Ltd | Radiotherapy apparatus using transmission type dosimeter |
| US8784290B2 (en) * | 2009-07-17 | 2014-07-22 | Cyberheart, Inc. | Heart treatment kit, system, and method for radiosurgically alleviating arrhythmia |
| WO2011053802A2 (en) | 2009-10-30 | 2011-05-05 | Tomotherapy Incorporated | Non-voxel-based broad-beam (nvbb) algorithm for intensity modulated radiation therapy dose calculation and plan optimization |
| US9014779B2 (en) | 2010-02-01 | 2015-04-21 | Proteus Digital Health, Inc. | Data gathering system |
| EP2531096A4 (en) | 2010-02-01 | 2013-09-11 | Proteus Digital Health Inc | Two-wrist data gathering system |
| US9000401B2 (en) | 2010-07-07 | 2015-04-07 | Institut National D'optique | Fiber optic radiochromic dosimeter probe and method to make the same |
| EP2420861A1 (en) * | 2010-08-20 | 2012-02-22 | Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO | A radiation dose meter for measuring radiation dose in an external magnetic field |
| BR112013005406A2 (en) * | 2010-09-09 | 2020-02-18 | Koninklijke Philps Electronics N.V. | DOSIMETER, THERAPEUTIC APPLIANCE AND COMPUTER PROGRAM PRODUCT |
| AU2010360735B2 (en) | 2010-09-13 | 2016-02-18 | Rmit University | Brachytherapy dose verification apparatus, system and method |
| DE102010048233B4 (en) * | 2010-10-12 | 2014-04-30 | Gsi Helmholtzzentrum Für Schwerionenforschung Gmbh | Method for generating an irradiation planning and method for applying a spatially resolved radiation dose |
| US8885986B2 (en) | 2011-05-02 | 2014-11-11 | Radiadyne Llc | Small diameter radiation sensor cable |
| DE102011085773B4 (en) | 2011-11-04 | 2014-08-21 | Siemens Aktiengesellschaft | Dose reconstruction in radiotherapy |
| CN105027227B (en) | 2013-02-26 | 2017-09-08 | 安科锐公司 | Electromagnetically actuated multi-diaphragm collimator |
| US10926111B2 (en) * | 2019-03-21 | 2021-02-23 | Vieworks Co., Ltd. | Bragg peak detector using scintillators and method of operating the same |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308988A (en) * | 1992-05-18 | 1994-05-03 | Radiation Measurements, Inc. | Analyzer for radiotherapy radiation beam |
| US5444254A (en) * | 1992-06-12 | 1995-08-22 | Thomson And Nielsen Electronics Ltd. | Flexible radiation probe |
| US5811822A (en) * | 1997-04-29 | 1998-09-22 | The United States Of America As Represented By The Secretary Of The Navy | Optically transparent, optically stimulable glass composites for radiation dosimetry |
| US6087666A (en) * | 1998-02-18 | 2000-07-11 | The United States Of America As Represented By The Secretary Of The Navy | Optically stimulated luminescent fiber optic radiation dosimeter |
| US6402689B1 (en) * | 1998-09-30 | 2002-06-11 | Sicel Technologies, Inc. | Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors |
| US8636648B2 (en) * | 1999-03-01 | 2014-01-28 | West View Research, Llc | Endoscopic smart probe |
| US6551232B1 (en) * | 1999-08-19 | 2003-04-22 | New England Medical Center | Dosimetry for californium-252(252Cf) neutron-emitting brachytherapy sources and encapsulation, storage, and clinical delivery thereof |
| US6504899B2 (en) | 2000-09-25 | 2003-01-07 | The Board Of Trustees Of The Leland Stanford Junior University | Method for selecting beam orientations in intensity modulated radiation therapy |
| US20020193685A1 (en) * | 2001-06-08 | 2002-12-19 | Calypso Medical, Inc. | Guided Radiation Therapy System |
| US7557353B2 (en) * | 2001-11-30 | 2009-07-07 | Sicel Technologies, Inc. | Single-use external dosimeters for use in radiation therapies |
| US6961405B2 (en) * | 2002-10-07 | 2005-11-01 | Nomos Corporation | Method and apparatus for target position verification |
| US20050059879A1 (en) * | 2003-09-16 | 2005-03-17 | Robert Sutherland | Localization of a sensor device in a body |
| US7399977B2 (en) * | 2004-07-23 | 2008-07-15 | University Health Network | Apparatus and method for determining radiation dose |
| US20060027756A1 (en) * | 2004-08-09 | 2006-02-09 | Ian Thomson | Dosimeter having an array of sensors for measuring ionizing radiation, and dosimetry system and method using such a dosimeter |
-
2004
- 2004-03-04 AT AT04717501T patent/ATE528039T1/en not_active IP Right Cessation
- 2004-03-04 CA CA2518769A patent/CA2518769C/en not_active Expired - Fee Related
- 2004-03-04 WO PCT/US2004/006905 patent/WO2004080522A1/en active Application Filing
- 2004-03-04 AU AU2004220539A patent/AU2004220539B8/en not_active Ceased
- 2004-03-04 EP EP04717501A patent/EP1608427B1/en not_active Expired - Lifetime
-
2005
- 2005-03-04 US US10/548,391 patent/US7554090B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070058778A1 (en) | 2007-03-15 |
| ATE528039T1 (en) | 2011-10-15 |
| EP1608427A4 (en) | 2008-06-18 |
| US7554090B2 (en) | 2009-06-30 |
| AU2004220539B8 (en) | 2011-01-06 |
| EP1608427B1 (en) | 2011-10-12 |
| AU2004220539A1 (en) | 2004-09-23 |
| AU2004220539B2 (en) | 2010-09-02 |
| EP1608427A1 (en) | 2005-12-28 |
| WO2004080522A1 (en) | 2004-09-23 |
| CA2518769C (en) | 2012-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2518769A1 (en) | Apparatus and process for dose-guided radiotherapy | |
| US3794840A (en) | Method and apparatus for directing a radiation beam toward a tumor or the like | |
| US9351691B2 (en) | Apparatus and method for external beam radiation distribution mapping | |
| US8093549B2 (en) | Radiation beam analyzer and method | |
| US7399977B2 (en) | Apparatus and method for determining radiation dose | |
| Low et al. | Phantoms for IMRT dose distribution measurement and treatment verification | |
| Suchowerska et al. | Clinical trials of a urethral dose measurement system in brachytherapy using scintillation detectors | |
| Oraiqat et al. | An ionizing radiation acoustic imaging (iRAI) technique for real‐time dosimetric measurements for FLASH radiotherapy | |
| US20070129593A1 (en) | Apparatus and method for brachytherapy radiation distribution mapping | |
| CN202715135U (en) | Mobile X-ray unit | |
| US20050101824A1 (en) | Implantable radiotherapy/brachytherapy radiation detecting apparatus and methods | |
| KR100921342B1 (en) | Measuring device for amount of radioactive rays | |
| WO2000007037A1 (en) | Dynamic radiation scanning device | |
| US8790234B2 (en) | Brachytherapy system and in vivo dose detector therefor | |
| WO2004041060A3 (en) | System and method for cancer detection | |
| Carrara et al. | Semiconductor real-time quality assurance dosimetry in brachytherapy | |
| KR101900463B1 (en) | A water dosimeter device using x-ray acoustic signal | |
| US20180036555A1 (en) | Rectal phantom unit and phantom device including the same | |
| Moros et al. | Clinical system for simultaneous external superficial microwave hyperthermia and cobalt-60 radiation | |
| KR102273851B1 (en) | Quality Assurance Phantom Device for Brachytherapy | |
| Bravo-Miranda et al. | Measurement of rectum dose by in vivo alanine/ESR dosimetry in gynecological 192Ir HDR brachytherapy | |
| WO2015107179A1 (en) | Minimally invasive applicator for in-situ radiation dosimetry | |
| CN212090534U (en) | Boron-10-containing drug concentration distribution measuring device suitable for BNCT system | |
| Sampath et al. | The dosimetric influence of central vaginal cylinders in high dose rate (HDR) iridium (Ir192) brachytherapy treatment | |
| KR100489592B1 (en) | Apparatus for measuring an accuracy of radiation dose for a standard stereotatic radiosurgery |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150304 |