CA2520032A1 - Aerosolization apparatus with air inlet shield - Google Patents

Aerosolization apparatus with air inlet shield Download PDF

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Publication number
CA2520032A1
CA2520032A1 CA002520032A CA2520032A CA2520032A1 CA 2520032 A1 CA2520032 A1 CA 2520032A1 CA 002520032 A CA002520032 A CA 002520032A CA 2520032 A CA2520032 A CA 2520032A CA 2520032 A1 CA2520032 A1 CA 2520032A1
Authority
CA
Canada
Prior art keywords
chamber
end section
pharmaceutical formulation
user
shield
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002520032A
Other languages
French (fr)
Other versions
CA2520032C (en
Inventor
Michael John Dunkley
Jonathan David Tuckwell
Edward William Vernon-Harcourt
Sameer Shirgaonkar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BGP Products Operations GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33299853&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2520032(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2520032A1 publication Critical patent/CA2520032A1/en
Application granted granted Critical
Publication of CA2520032C publication Critical patent/CA2520032C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Abstract

An aerosolization apparatus (100) comprises a housing (105) defining a chamber (110) having a plurality of air inlets (115). The chamber (110) contains an aersolizable pharmaceutical formulation or is sized to receive a receptacle (125) which contains an aerosolizable pharmaceutical formulation. A shield (170) covers at least one of the air inlets (115) or a portion of at least one of the air inlets (115). The shield (170) prevents blockage of the air inlet (115) by a user grasping the apparatus (100) and inadvertently covering the air inlet (115). An end section (140) is associated with the housing (105).
The end section (140) is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section (140) to inhale aerosolized pharmaceutical formulation that has exited the receptacle (125).

Claims (31)

1. A handheld aerosolization apparatus comprising:
a housing defining a chamber having a plurality of air inlets, the chamber being sized to receive a receptacle which contains an aerosolizable pharmaceutical formulation;
a shield which covers at least one but not all of the air inlets, whereby the shield prevents blockage of the at least one air inlet by a user grasping the apparatus; and an end section associated with the housing, the end section sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the receptacle.
2. An apparatus according to claim 1 wherein the shield is a portion of the end section.
3. An apparatus according to claim 1 wherein the end section is removably connected to the housing and wherein the end section may be removed from the housing to provide access to the chamber.
4. An apparatus according to claim 3 wherein the shield is a portion of the end section.
5. An apparatus according to claim 1 wherein the shield comprises at least two covering portions, each covering portion covering at least one inlet.
6. An apparatus according to claim 5 wherein there are two covering portions and wherein the two covering portions are diametrically opposed.
7. An apparatus according to claim 5 wherein the at least two covering portions are separated by open portions.
8. An apparatus according to claim 7 wherein the open portions provide direct access to at least one inlet.
9. An apparatus according to claim 1 wherein the shield extends longitudinally along the apparatus.
10. An apparatus according to claim 1 wherein the receptacle is a capsule and further comprising a puncturing mechanism in the housing for creating one or more openings in the capsule.
11. An apparatus according to claim 10 wherein the puncture member is adapted to puncture only one end of the capsule.
12. An apparatus according to claim 10 wherein the chamber is elongated and wherein the capsule is received lengthwise within the elongated chamber.
13. An apparatus according to claim 1 wherein the inlet is shaped to create a swirling airflow within the chamber.
14. A handheld aerosolization apparatus comprising:
a housing defining a chamber having a plurality of air inlets, the chamber being sized to receive a receptacle which contains an aerosolizable pharmaceutical formulation;
a shield which covers a portion of but not all of at least one of the air inlets; and an end section associated with the housing, the end section sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the receptacle.
15. An apparatus according to claim 14 wherein the shield is a portion of the end section.
16. An apparatus according to claim 14 wherein the end section is removably connected to the housing and wherein the end section may be removed from the housing to provide access to the chamber.
17. An apparatus according to claim 16 wherein the shield is a portion of the end section.
18. An apparatus according to claim 14 wherein the inlet is shaped to create a swirling airflow within the chamber.
19. A handheld aerosolization apparatus comprising:
a housing defining a chamber having one or more air inlets, the chamber being sized to receive a receptacle which contains an aerosolizable pharmaceutical formulation;
a shield extending around only a portion of transverse circumference of the housing, the shield covering at least one air inlets, whereby the shield prevents blockage of the at least one air inlet by a user grasping the apparatus; and an end section associated with the housing, the end section sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the receptacle.
20. An apparatus according to claim 19 wherein the shield is a portion of the end section.
21. An apparatus according to claim 19 wherein the end section is removably connected to the housing and wherein the end section may be removed from the housing to provide access to the chamber.
22. An apparatus according to claim 21 wherein the shield is a portion of the end section.
23. An apparatus according to claim 19 wherein the inlet is shaped to create a swirling airflow within the chamber.
24. A method of aerosolizing a pharmaceutical formulation, the method comprising:
providing an aerosolizable pharmaceutical formulation in a chamber, the chamber having a plurality of air inlets;
shielding at least one but not all of the air inlets from being blocked by a user grasping the chamber;
aerosolizing the pharmaceutical formulation by flowing air through the chamber; and administering the aerosolized pharmaceutical formulation to the respiratory tract of a user during the user's inhalation.
25. A method according to claim 24 wherein the pharmaceutical formulation is contained within a capsule and further comprising the step of inserting the capsule into the chamber.
26. A method according to claim 25 further comprising puncturing the capsule within the chamber.
27. A method according to claim 24 wherein the user's inhalation causes the air to flow through the chamber.
28. A method of aerosolizing a pharmaceutical formulation, the method comprising:
providing an aerosolizable pharmaceutical formulation in a chamber, the chamber having one or more air inlets;
shielding only a portion of at least one of the air inlets from being blocked by a user grasping the chamber;
aerosolizing the pharmaceutical formulation by flowing air through the chamber; and administering the aerosolized pharmaceutical formulation to the respiratory tract of a user during the user's inhalation.
29. A method according to claim 28 wherein the pharmaceutical formulation is contained within a capsule and further comprising the step of inserting the capsule into the chamber.
30. A method according to claim 29 further comprising puncturing the capsule within the chamber.
31. A method according to claim 28 wherein the user's inhalation causes the air to flow through the chamber.
CA2520032A 2003-04-09 2004-04-09 Aerosolization apparatus with air inlet shield Expired - Lifetime CA2520032C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46167903P 2003-04-09 2003-04-09
US60/461,679 2003-04-09
PCT/US2004/010928 WO2004091705A1 (en) 2003-04-09 2004-04-09 Aerosolization apparatus with air inlet shield

Publications (2)

Publication Number Publication Date
CA2520032A1 true CA2520032A1 (en) 2004-10-28
CA2520032C CA2520032C (en) 2012-10-16

Family

ID=33299853

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2520032A Expired - Lifetime CA2520032C (en) 2003-04-09 2004-04-09 Aerosolization apparatus with air inlet shield

Country Status (15)

Country Link
US (3) US7559325B2 (en)
EP (1) EP1610850B2 (en)
JP (1) JP4943838B2 (en)
KR (1) KR101066788B1 (en)
AT (1) ATE549051T1 (en)
AU (1) AU2004229446B2 (en)
CA (1) CA2520032C (en)
CY (1) CY1113859T1 (en)
DK (1) DK1610850T3 (en)
ES (1) ES2383367T5 (en)
MX (1) MXPA05010842A (en)
PL (1) PL1610850T3 (en)
PT (1) PT1610850E (en)
SI (1) SI1610850T2 (en)
WO (1) WO2004091705A1 (en)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040206350A1 (en) * 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
EP1615689B1 (en) * 2003-04-09 2016-02-03 Novartis AG Aerosolization apparatus with capsule puncture alignment guide
US8869794B1 (en) * 2003-04-09 2014-10-28 Novartis Pharma Ag Aerosolization apparatus with capsule puncturing member
PT1610850E (en) * 2003-04-09 2012-06-15 Novartis Ag Aerosolization apparatus with air inlet shield
US7658721B2 (en) * 2004-01-16 2010-02-09 Biodel Inc. Sublingual drug delivery device
WO2005102429A1 (en) * 2004-04-21 2005-11-03 Innovata Biomed Limited Inhaler
US20070051362A1 (en) * 2004-04-23 2007-03-08 Sullivan Timothy R Multiple unit dose drug delivery system
PL370286A1 (en) * 2004-09-23 2006-04-03 Glaxosmithkline Pharmaceuticals Spółka Akcyjna Powder inhaler - capsules opening and emptying system
GB0503738D0 (en) 2005-02-23 2005-03-30 Optinose As Powder delivery devices
DE102005038619A1 (en) * 2005-08-16 2007-02-22 Pari GmbH Spezialisten für effektive Inhalation An inhalation therapy device with an ampoule for storing a medicament to be nebulised
AU2006297394B9 (en) * 2005-09-29 2013-09-19 Novartis Ag Receptacles and kits, such as for dry powder packaging
NL1033047C2 (en) * 2006-12-13 2008-06-16 Pharmachemie Bv Capsule filled with a medicine, in particular an inhalable medicine.
WO2008086413A2 (en) 2007-01-09 2008-07-17 Mystic Pharmaceuticals, Inc. Intranasal cartridge devices
US9248076B2 (en) 2007-05-16 2016-02-02 Mystic Pharmaceuticals, Inc. Dose dispensing containers
US8683995B2 (en) 2007-05-16 2014-04-01 Mystic Pharmaceuticals, Inc. Dose dispensing containers
CN105776119B (en) 2007-05-16 2019-04-23 神秘制药公司 Combination unit dose dispensing containers
WO2008156586A2 (en) * 2007-06-12 2008-12-24 Alkermes, Inc. Inhalation device for powdered substances
CN103707452B (en) * 2007-09-14 2017-05-03 神秘制药公司 Deep draw container forming method
DE102007056462B4 (en) 2007-11-23 2011-10-27 Pari Pharma Gmbh Disposable ampoule for a device for generating aerosols
MX2010012452A (en) * 2008-05-15 2011-03-15 Novartis Ag Star Pulmonary delivery of a fluoroquinolone.
US20130047985A1 (en) * 2010-04-23 2013-02-28 3M Innovative Properties Company Dry powder inhaler assembly and containers
CA2841390C (en) * 2011-07-13 2019-08-27 Pharmaxis Ltd Medicament delivery device having improved powder emission and deagglomeration
US8327610B1 (en) * 2011-12-16 2012-12-11 JCDS Holdings, LLC Capsule opener and emptier
US20150367366A1 (en) * 2012-12-06 2015-12-24 Aerodesigns, Inc. Aerosol dispenser with edible cartridge
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
WO2014141069A1 (en) 2013-03-14 2014-09-18 Novartis Ag Deamorphization of spray-dried formulations via spray-blending
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
JP2016518388A (en) 2013-04-30 2016-06-23 オティトピック インク． Dry powder formulation and usage
WO2015012758A1 (en) * 2013-07-22 2015-01-29 Inhalation Sciences Sweden Ab Apparatus and method for generating an aerosol
MX2016002844A (en) * 2013-09-19 2016-06-17 Philip Morris Products Sa Aerosol-generating system for generating nicotine salt particles.
EP3089607B1 (en) * 2014-01-02 2019-12-11 Philip Morris Products S.a.s. Aerosol-generating system comprising a cylindrical polymeric capsule
WO2015127315A1 (en) 2014-02-20 2015-08-27 Otitopic Inc. Dry powder formulations for inhalation
NO2709641T3 (en) * 2014-03-10 2018-05-12
CA2940599A1 (en) 2014-03-27 2015-10-01 Novartis Ag Spray-dried solid-in-oil-in-water dispersions for inhalation of active pharmaceutical ingredients
AU2016228976B2 (en) 2015-03-11 2018-11-08 University Of Cincinnati Compositions and methods for treating bacterial infection
RU2711313C2 (en) * 2015-04-15 2020-01-16 Филип Моррис Продактс С.А. Powder inhaler providing delivery of portion of dry powder dose
CA2992171A1 (en) 2015-09-09 2017-03-16 Novartis Ag Targeted delivery of spray-dried formulations to the lungs
DK3347377T3 (en) 2015-09-09 2021-05-10 Novartis Ag Thymic stromal lymphopoietin (TSLP) -binding antibodies and methods of using the antibodies
TN2018000076A1 (en) 2015-09-09 2019-07-08 Novartis Ag Thymic stromal lymphopoietin (tslp)-binding molecules and methods of using the molecules
GB201615601D0 (en) 2016-09-14 2016-10-26 British American Tobacco Investments Ltd Receptacle section
GB201615602D0 (en) * 2016-09-14 2016-10-26 British American Tobacco Investments Ltd Receptacle Section
JP7061124B2 (en) 2016-11-30 2022-04-27 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム Inhaler with spiral end plug
KR102545359B1 (en) * 2016-11-30 2023-06-20 필립모리스 프로덕츠 에스.에이. Inhalers with custom-sized cavities
GB201700136D0 (en) 2017-01-05 2017-02-22 British American Tobacco Investments Ltd Aerosol generating device and article
GB201700620D0 (en) 2017-01-13 2017-03-01 British American Tobacco Investments Ltd Aerosol generating device and article
US10195147B1 (en) 2017-09-22 2019-02-05 Otitopic Inc. Dry powder compositions with magnesium stearate
US10786456B2 (en) 2017-09-22 2020-09-29 Otitopic Inc. Inhaled aspirin and magnesium to treat inflammation
CN107737393B (en) * 2017-10-12 2020-08-28 上海新黄河制药有限公司 Preparation atomization flow passage for powder aerosol inhalation device
CN107715264B (en) * 2017-10-12 2021-01-29 上海新黄河制药有限公司 Dispersion/depolymerization device of powder agglomeration of powder aerosol device preparation
GB201720338D0 (en) 2017-12-06 2018-01-17 British American Tobacco Investments Ltd Component for an aerosol-generating apparatus
CN111465423B (en) 2017-12-28 2022-08-16 菲利普莫里斯生产公司 Inhaler with swirl channel
EP3772252B1 (en) * 2018-03-26 2022-05-04 Philip Morris Products S.A. Inhaler with apertured porous support element
BR112021024979A2 (en) 2019-06-10 2022-01-25 Respira Therapeutics Inc Carrier-based formulations and related methods
KR20230156916A (en) * 2021-03-16 2023-11-15 필립모리스 프로덕츠 에스.에이. Inhaler item holder for high dose delivery

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3012694A (en) 1958-10-22 1961-12-12 Johnston William Derrick Gas dispensing device
US3809084A (en) 1970-02-16 1974-05-07 American Cyanamid Co Pressurized portable dispenser
US3888253A (en) 1972-08-04 1975-06-10 Beecham Group Ltd Device for administration of medicines
FR2224175B1 (en) 1973-04-04 1978-04-14 Isf Spa
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
DE2346914C3 (en) * 1973-09-18 1980-10-16 Paul Ritzau Pari-Werk, Gmbh & Co, 8130 Starnberg Powdered substance inhaler
IT1016489B (en) 1974-03-18 1977-05-30 Isf Spa INHALER
SE408265B (en) 1975-12-12 1979-06-05 Draco Ab DEVICE FOR CARBON DIOXIDE POWERED ENDOSAEROSOL, INTENDED FOR INHALATION
GB1562732A (en) * 1976-02-10 1980-03-12 Allen & Hanburys Ltd Device for dispensing medicaments
US4247066A (en) 1978-02-21 1981-01-27 General Dynamics Corporation Airfoil variable cambering device and method
US4238931A (en) * 1979-01-25 1980-12-16 Energy Conservation Unlimited, Inc. Waste heat recovery system controller
IT1116047B (en) 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti DEVICE FOR THE QUICK INHALATION OF POWDER DRUGS BY PERSONS SUFFERING FROM ASTHMA
US4265236A (en) 1980-03-31 1981-05-05 Pacella Angelo M Portable inhalator device
DE3345722A1 (en) 1983-12-17 1985-06-27 Boehringer Ingelheim KG, 6507 Ingelheim INHALATOR
DE3634952A1 (en) 1986-10-14 1988-04-21 Bayer Ag IMIDAZO-PYRROLO-PYRIDINE DERIVATIVES
IT1222509B (en) 1987-08-17 1990-09-05 Miat Spa INSUFFLATOR FOR THE ADMINISTRATION OF DRUGS IN THE FORM OF PRE-DOSED POWDER IN OPERATIONS
IT1228460B (en) 1989-02-23 1991-06-19 Phidea S R L DISPOSABLE INHALER WITH PRE-PERFORATED CAPSULE
IT1228459B (en) 1989-02-23 1991-06-19 Phidea S R L INHALER WITH REGULAR AND COMPLETE EMPTYING OF THE CAPSULE.
US5201308A (en) * 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
ES2284226T3 (en) 1991-07-02 2007-11-01 Nektar Therapeutics DEVICE FOR PROVIDING MEDICATIONS IN AEROSOL.
US6681767B1 (en) 1991-07-02 2004-01-27 Nektar Therapeutics Method and device for delivering aerosolized medicaments
US5287850A (en) * 1991-08-20 1994-02-22 Habley Medical Technology Corporation Timing and velocity controlled powered pharmaceutical inhaler
DE4211475A1 (en) * 1991-12-14 1993-06-17 Asta Medica Ag POWDER INHALATOR
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
GB9216038D0 (en) 1992-07-28 1992-09-09 Bespak Plc Dispensing apparatus for powdered medicaments
ES2171455T3 (en) * 1993-06-29 2002-09-16 Ponwell Entpr Ltd DISPENSER.
SE9302550D0 (en) 1993-07-30 1993-07-30 Ernst Hoerlin POWDER INHALES
WO1995024183A1 (en) 1994-03-07 1995-09-14 Inhale Therapeutic Systems Methods and compositions for pulmonary delivery of insulin
JP3372105B2 (en) * 1994-05-26 2003-01-27 株式会社日立ユニシアオートモティブ Inhalation type dispenser
JP3388896B2 (en) 1994-08-08 2003-03-24 株式会社日立ユニシアオートモティブ Inhalation type dispenser
CA2200727C (en) 1994-09-21 2006-11-28 Adrian E. Smith Apparatus and methods for dispersing dry powder medicaments
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
JP3308425B2 (en) 1995-03-10 2002-07-29 株式会社ユニシアジェックス Nasal administration device
AU706195B2 (en) 1995-04-14 1999-06-10 Inhale Therapeutic Systems Powdered pharmaceutical formulations having improved dispersibility
DE19523516C1 (en) † 1995-06-30 1996-10-31 Asta Medica Ag Inhaler for administering medication from blister packs
AUPN976496A0 (en) 1996-05-10 1996-05-30 Glaxo Wellcome Australia Ltd Unit dose dispensing device
US6503480B1 (en) 1997-05-23 2003-01-07 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
GB2318737B (en) 1996-10-30 2000-06-14 Bespak Plc Improved inhalers
GB9626233D0 (en) 1996-12-18 1997-02-05 Chawla Brinda P S Medicament packaging and deliveery device
EP1019021B2 (en) 1997-09-29 2012-12-26 Novartis AG Stabilized preparations for use in metered dose inhalers
SK9562000A3 (en) 1997-12-22 2000-11-07 Astrazeneca Ab A suction tube and inhalation device comprising such a tube
NZ506289A (en) 1998-03-16 2004-12-24 Nektar Therapeutics Aerosolized active agent delivery to the lungs at a flow rate of less than 17 liters per minute
SE9800897D0 (en) 1998-03-17 1998-03-17 Astra Ab Inhalation device
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
DE19835346A1 (en) 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Two-part capsule for pharmaceutical preparations for powder inhalers
US5992675A (en) 1998-09-15 1999-11-30 Browne & Co. Inc./Cie Ltee Splatter screen
JP2000217917A (en) * 1999-01-27 2000-08-08 Unisia Jecs Corp Inhaler type medicine administration tool
DE60041610D1 (en) 1999-05-28 2009-04-02 Nektar Therapeutics Apparatus for dispensing metered quantities of medicament-containing aerosol
KR100863630B1 (en) * 1999-09-25 2008-10-15 유니버시티 오브 아이오와 리써치 파운데이션 Immunostimulatory Nucleic Acids
US20010029947A1 (en) 1999-12-17 2001-10-18 Steve Paboojian Receptacles to facilitate the extraction of powders
US6427688B1 (en) 2000-02-01 2002-08-06 Dura Pharmaceuticals, Icn. Dry powder inhaler
SE0000935D0 (en) 2000-03-21 2000-03-21 Astrazeneca Ab An inhalation device
US20020000225A1 (en) 2000-06-02 2002-01-03 Carlos Schuler Lockout mechanism for aerosol drug delivery devices
GB2364919A (en) 2000-07-21 2002-02-13 Cambridge Consultants Inhalers
PT1303326E (en) * 2000-07-24 2012-10-11 Clinical Designs Ltd Dispenser
US6357490B1 (en) 2000-08-22 2002-03-19 Advanced Inhalation Research, Inc. System, method and apparatus for filling containers
US6766799B2 (en) 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device
US7905230B2 (en) 2001-05-09 2011-03-15 Novartis Ag Metered dose inhaler with lockout
TW553752B (en) * 2001-06-20 2003-09-21 Inhale Therapeutic Syst Powder aerosolization apparatus and method
US20030094173A1 (en) 2001-11-14 2003-05-22 Inhale Therapeutic Systems, Inc. Aerosolization device with improved endpiece connection
EP1443996B1 (en) 2001-11-14 2011-05-18 Novartis AG Aerosolization apparatus comprising connectable body and endpiece
US20030168057A1 (en) 2001-12-14 2003-09-11 Inhale Therapeutic Systems, Inc. Electronically controllable aerosol delivery
ITMI20020078A1 (en) 2002-01-16 2003-07-16 Fabrizio Niccolai DEVICE USABLE IN THE TREATMENT OF RESPIRATORY TRACT AFFECTIONS
US7185651B2 (en) 2002-06-18 2007-03-06 Nektar Therapeutics Flow regulator for aerosol drug delivery and methods
WO2004041340A2 (en) 2002-10-30 2004-05-21 Nektar Therapeutics Increased dosage metered dose inhaler
US7516741B2 (en) 2002-12-06 2009-04-14 Novartis Ag Aerosolization apparatus with feedback mechanism
US20040206350A1 (en) 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
US20050081852A1 (en) 2002-12-30 2005-04-21 Nektar Therapeutics (Formely Inhale Therapeutic System Inc.) Package for an aerosolization apparatus and pharmaceutical formulation receptacle
US7669596B2 (en) 2002-12-31 2010-03-02 Novartis Pharma Ag Aerosolization apparatus with rotating capsule
US20050056280A1 (en) 2002-12-31 2005-03-17 Nektar Therapeutics Receptacle for an aerosolizable pharmaceutical formulation
EP1603615B1 (en) 2003-03-20 2008-07-09 Galephar M/F Improved dry powder inhaler system
EP1615689B1 (en) 2003-04-09 2016-02-03 Novartis AG Aerosolization apparatus with capsule puncture alignment guide
PT1610850E (en) 2003-04-09 2012-06-15 Novartis Ag Aerosolization apparatus with air inlet shield
AU2004249166B2 (en) 2003-06-13 2008-10-09 Alkermes, Inc. Low dose pharmaceutical powders for inhalation
US7046799B2 (en) * 2003-09-12 2006-05-16 Motorola, Inc. Communication headset and method
DE10350555A1 (en) 2003-10-29 2005-06-09 Hugo Kern Und Liebers Gmbh & Co. Platinen- Und Federnfabrik inhaler
WO2009075794A1 (en) 2007-12-05 2009-06-18 Nektar Therapeutics Receptacle for an aerosolizable pharmaceutical formulation

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PT1610850E (en) 2012-06-15
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US8069851B2 (en) 2011-12-06
KR101066788B1 (en) 2011-09-21
SI1610850T1 (en) 2012-09-28
ES2383367T5 (en) 2021-03-31
CA2520032C (en) 2012-10-16
EP1610850A1 (en) 2006-01-04
EP1610850B1 (en) 2012-03-14
US20090260623A1 (en) 2009-10-22
ATE549051T1 (en) 2012-03-15
ES2383367T3 (en) 2012-06-20
MXPA05010842A (en) 2006-03-30
EP1610850B2 (en) 2020-08-05
US7559325B2 (en) 2009-07-14
SI1610850T2 (en) 2020-11-30
DK1610850T3 (en) 2012-06-25
JP2006522663A (en) 2006-10-05
AU2004229446A1 (en) 2004-10-28
USRE47526E1 (en) 2019-07-23
CY1113859T1 (en) 2016-07-27
WO2004091705A1 (en) 2004-10-28
AU2004229446B2 (en) 2010-02-25
JP4943838B2 (en) 2012-05-30
PL1610850T3 (en) 2012-11-30

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