CA2525240A1 - Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers - Google Patents

Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers Download PDF

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Publication number
CA2525240A1
CA2525240A1 CA002525240A CA2525240A CA2525240A1 CA 2525240 A1 CA2525240 A1 CA 2525240A1 CA 002525240 A CA002525240 A CA 002525240A CA 2525240 A CA2525240 A CA 2525240A CA 2525240 A1 CA2525240 A1 CA 2525240A1
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CA
Canada
Prior art keywords
light
biosensor
tunable
wavelength
sensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002525240A
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French (fr)
Other versions
CA2525240C (en
Inventor
Brian T. Cunningham
Peter Y. Li
Constance Chang-Hasnain
Carlos Mateus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
SRU Biosystems Inc
Original Assignee
Sru Biosystems, Inc.
The Regents Of The University Of California
Brian T. Cunningham
Peter Y. Li
Constance Chang-Hasnain
Carlos Mateus
Sru Biosystems, Llc
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Publication date
Application filed by Sru Biosystems, Inc., The Regents Of The University Of California, Brian T. Cunningham, Peter Y. Li, Constance Chang-Hasnain, Carlos Mateus, Sru Biosystems, Llc filed Critical Sru Biosystems, Inc.
Priority to CA2723087A priority Critical patent/CA2723087A1/en
Publication of CA2525240A1 publication Critical patent/CA2525240A1/en
Application granted granted Critical
Publication of CA2525240C publication Critical patent/CA2525240C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Plasma & Fusion (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

An apparatus and method for detection of peak wavelength values of colorimetric resonant optical biosensors using tunable filters and tunable lasers is provided. Biomolecular interactions may be detected on a biosensor by directing collimated white light towards a surface of the biosensor.
Molecular binding on the surface of the biosensor is indicated by a shift in the peak wavelength value of reflected or transmitted light from the biosensor, while an increase in the wavelength corresponds to an increase in molecular absorption. A tunable laser light source may generate the collimated white light and a tunable filter may receive the reflected or transmitted light and pass the light to a photodiode sensor. The photodiode sensor then quantifies an amount of the light reflected or transmitted through the tunable filter as a function of the tuning voltage of the tunable filter.

Claims (38)

1. A measuring apparatus for detecting a biochemical interaction on a biosensor, the measuring apparatus comprising:
a light source for generating collimated white light and directing the collimated white light towards a surface of the biosensor; and a tunable filter operable to receive light transmitted through the biosensor and to pass a narrow band of light having wavelengths substantially centered at a passband wavelength and to reflect substantially all other wavelengths, wherein the passband wavelength is adjusted according to a tuning voltage of the tunable filter.
2. The invention of claim 1, wherein the tunable filter is a micro-electro-mechanical (MEM) cantilever device.
3. The invention of claim 1, wherein the tunable filter includes a vertical cavity surface emitting laser (VCSEL).
4. The invention of claim 1, wherein the light source is an LED.
5. The invention of claim 1, wherein the light source is a tunable laser.
6. The invention of claim 5, wherein the tunable laser is a vertical cavity surface emitting laser (VCSEL).
7. The invention of claim 1, wherein the biosensor is a colorimetric resonant optical biosensor.
8. The invention of claim 1, wherein the passband wavelength is adjustable over a wavelength range that includes a biosensor resonant wavelength.
9. The invention of claim 1, wherein the tuning voltage is adjusted as a function of time, so as to sweep the passband wavelength.
10. The invention of claim 1, further comprising a photodiode sensor positioned to receive the narrow band of light having wavelengths substantially centered at the passband wavelength from the tunable filter.
11. The invention of claim 10, wherein the tunable filter includes the photodiode sensor.
12. The invention of claim 10, wherein an output of the photodiode sensor quantifies an amount of the light transmitted through the tunable filter as a function of the tuning voltage of the tunable filter.
13. The invention of claim 1, further comprising a plurality of tunable filters, wherein each tunable filter measures light transmitted through a respective region of the biosensor.
14. ~The invention of claim 13, wherein the plurality of tunable filters are arranged in a linear array.
15. ~A measuring apparatus for detecting a biochemical interaction on a biosensor, the measuring apparatus comprising:
a tunable laser light source for generating light having a tunable laser wavelength and for directing the light towards a surface of the biosensor, wherein the tunable laser wavelength is tuned by adjusting a tuning voltage; and a photodiode detector operable to receive light transmitted through the biosensor and to detect a broad band of wavelengths encompassing a wavelength passband, wherein an output of the photodiode detector quantifies an amount of the light transmitted through the biosensor as a function of the tuning voltage.
16. ~The invention of claim 15, wherein the tuning voltage adjusts the tunable laser wavelength over a range of wavelength that encompasses a biosensor resonant wavelength.
17. ~The invention of claim 15, wherein the biosensor is illuminated at normal incidence by the tunable laser light source.
18. ~The invention of claim 15, wherein the tunable laser light source is a vertical cavity surface emitting laser (VCSEL).
19. The invention of claim 15, wherein the photodiode detector detects a minimum in intensity of the light transmitted through the biosensor as a function of wavelength.
20. The invention of claim 15, wherein the photodiode detector detects a wavelength of peak reflected intensity of the light transmitted through the biosensor.
21. The invention of claim 15, further comprising a plurality of tunable laser light sources, wherein where each tunable laser light source illuminates a respective region on the biosensor's surface.
22. The invention of claim 15, wherein the biosensor is a colorimetric resonant optical biosensor.
23. The invention of claim 15, further comprising a biosensor readout interface.
24. An apparatus for detecting a maximum wavelength of reflected light, the apparatus comprising:
a light source for generating collimated white light;
a power splitter for directing the collimated white light towards a surface of a sensor;
and a tunable detector that receives light reflected by the sensor and measures a radiation spectrum of the light reflected from the sensor, wherein the tunable detector filters a narrow band of light having wavelengths substantially centered at a passband wavelength from the light reflected by the sensor, where the passband wavelength is adjusted according to a tuning voltage of the tunable detector.
25. The invention of claim 24, wherein the tunable detector has a micro-electro-mechanical (MEM) cantilever device.
26. The invention of claim 24, wherein the tunable detector includes a vertical cavity surface emitting laser (VCSEL).
27. The invention of claim 24, wherein the light source is an LED.
28. The invention of claim 24, further comprising an optical fiber probe positioned to receive the collimated white light from the power splitter and to direct the collimated white light towards the surface of the sensor.
29. The invention of claim 28, wherein the optical fiber probe receives the light reflected by the sensor and directs the light reflected by the sensor to the tunable detector.
30. The invention of claim 24, further comprising a collimation device positioned to receive the collimated white light from the power splitter and to direct the collimated white light towards the surface of the sensor.
31 31. The invention of claim 24, wherein the sensor is a biosensor.
32. An apparatus for detecting a maximum wavelength of reflected light, the apparatus comprising:
a tunable laser light source for generating a tunable single wavelength of light, wherein the tunable laser light source is tuned by adjusting a tuning voltage;
an optical circulator for directing the tunable single wavelength of light towards a surface of a sensor; and a photodiode detector operable to receive light reflected from the biosensor and to detect a broad band of wavelengths encompassing a wavelength passband, wherein an output of the photodiode detector quantifies an amount of the light reflected from the biosensor as a function of the tuning voltage.
33. The invention of claim 32, wherein the sensor is a biosensor.
34. The invention of claim 32, wherein the tunable laser light source is a vertical cavity surface emitting laser (VCSEL).
35. The invention of claim 32, wherein a peak reflecting wavelength of the light reflected form the biosensor is determined by varying the tunable single wavelength of light emitted by the tunable laser light source.
36. The invention of claim 32, wherein as the tunable laser light source is tuned, only a resonance wavelength of the sensor is reflected from the sensor.
37. The invention of claim 32, further comprising a collimation device positioned to receive the single wavelength of light from the optical circulator and to direct the single wavelength of light towards the surface of the sensor.
38. The invention of claim 37, further comprising a beam expansion device positioned to receive the single wavelength of light from the collimation device and to direct the single wavelength of light towards the surface of the sensor.
CA2525240A 2003-05-08 2004-05-07 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers Expired - Fee Related CA2525240C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2723087A CA2723087A1 (en) 2003-05-08 2004-05-07 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/434,015 2003-05-08
US10/434,015 US7497992B2 (en) 2003-05-08 2003-05-08 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
PCT/US2004/014262 WO2004102193A2 (en) 2003-05-08 2004-05-07 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2723087A Division CA2723087A1 (en) 2003-05-08 2004-05-07 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers

Publications (2)

Publication Number Publication Date
CA2525240A1 true CA2525240A1 (en) 2004-11-25
CA2525240C CA2525240C (en) 2011-02-22

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CA2525240A Expired - Fee Related CA2525240C (en) 2003-05-08 2004-05-07 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers

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US (2) US7497992B2 (en)
EP (1) EP1623220B1 (en)
AT (1) ATE485511T1 (en)
AU (1) AU2004239726B2 (en)
CA (2) CA2723087A1 (en)
DE (1) DE602004029665D1 (en)
HK (1) HK1081271A1 (en)
NZ (1) NZ543982A (en)
WO (1) WO2004102193A2 (en)

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