CA2541779A1 - Form of administration based on crosslinked hydrophilic polymers - Google Patents

Form of administration based on crosslinked hydrophilic polymers Download PDF

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Publication number
CA2541779A1
CA2541779A1 CA002541779A CA2541779A CA2541779A1 CA 2541779 A1 CA2541779 A1 CA 2541779A1 CA 002541779 A CA002541779 A CA 002541779A CA 2541779 A CA2541779 A CA 2541779A CA 2541779 A1 CA2541779 A1 CA 2541779A1
Authority
CA
Canada
Prior art keywords
polyacrylic acid
active ingredient
nutrient
dosage form
hydrophilic polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002541779A
Other languages
French (fr)
Other versions
CA2541779C (en
Inventor
Johannes Bartholomaeus
Maria Christina Vazquez Lantes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2541779A1 publication Critical patent/CA2541779A1/en
Application granted granted Critical
Publication of CA2541779C publication Critical patent/CA2541779C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/005—Crosslinking of cellulose derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
    • C08J2333/02—Homopolymers or copolymers of acids; Metal or ammonium salts thereof

Abstract

The invention relates to a film-shaped form of administration for topically administering at least one agent and/or nutrient to a living being. Said form of administration comprises at least one agent-containing and/or nutrient-containing layer that is based on crosslinked hydrophilic polymers which are crosslinked with at least one polyacrylic acid derivative.

Claims (9)

1. A process for producing a dosage form in film form for surface administration of at least one active ingredient and/or nutrient to a living creature comprising at least one active ingredient-containing and/or nutrient-containing layer based on hydrophilic polymers crosslinked with at least one polyacrylic acid derivative by building up individual layers successively on a smooth surface, characterized by the steps:

a) simultaneous spraying of an aqueous solution of the hydrophilic polymers and of the active ingredient and/or of the nutrient and of an aqueous solution of the polyacrylic acid derivative, b) removal of the water by drying.
2. The production process as claimed in claim 1, characterized in that an optionally crosslinked polyacrylic acid, preferably a polyacrylic acid crosslinked with allylsucrose or allylpentaerythritol and/or a polyacrylic acid crosslinked with divinylglycol, where appropriate neutralized with calcium, is used as polyacrylic acid derivative.
3. The production process as claimed in claim 1 or 2, characterized in that hydroxypropylmethylcellulose, hydroxyethylcellulose and/or methylcellulose, preferably hydroxypropylmethylcellulose, is employed as hydrophilic polymer.
4. The production process as claimed in any of claims 1 to 3, characterized in that the weight ratio of hydrophilic polymers to polyacrylic acid derivative(s) is from 5:1 to 5:4, preferably 5:2 to 5:3.
5. A dosage form produced as claimed in any of claims 1 to 4.
6. The dosage form as claimed in claim 5, characterized in that it has at least one active ingredient-containing and/or nutrient-containing layer, a covering layer and where appropriate an adhesive layer.
7. The dosage form as claimed in claim 5 or 6, characterized in that at least one active ingredient-containing layer has a concentration gradient of the active ingredient.
8. The dosage form as claimed in any of claims 5 to 7, characterized in that the covering layer is impermeable for the active ingredient and/or nutrient.
9. The dosage form as claimed in any of claims 5 to 8, characterized in that it is covered with a protective layer before application.
CA2541779A 2003-12-12 2004-12-13 Form of administration based on crosslinked hydrophilic polymers Expired - Fee Related CA2541779C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10358748.9 2003-12-12
DE10358748A DE10358748A1 (en) 2003-12-12 2003-12-12 Dosage form based on crosslinked hydrophilic polymers
PCT/EP2004/014147 WO2005056648A1 (en) 2003-12-12 2004-12-13 Form of administration based on crosslinked hydrophilic polymers

Publications (2)

Publication Number Publication Date
CA2541779A1 true CA2541779A1 (en) 2005-06-23
CA2541779C CA2541779C (en) 2012-05-15

Family

ID=34672769

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2541779A Expired - Fee Related CA2541779C (en) 2003-12-12 2004-12-13 Form of administration based on crosslinked hydrophilic polymers

Country Status (9)

Country Link
US (1) US8133510B2 (en)
EP (1) EP1692216B1 (en)
JP (1) JP5420150B2 (en)
CN (1) CN100425639C (en)
CA (1) CA2541779C (en)
DE (1) DE10358748A1 (en)
ES (1) ES2397152T3 (en)
PL (1) PL1692216T3 (en)
WO (1) WO2005056648A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008021473A1 (en) * 2008-04-29 2009-11-12 Heraeus Kulzer Gmbh Dental materials equipped with antiplaque agent (s)
US9119793B1 (en) 2011-06-28 2015-09-01 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for doxycycline
AT511881B1 (en) * 2011-09-08 2015-02-15 Indoo Rs Gmbh METHOD AND SYSTEM FOR LOCATING A COMMUNICATION DEVICE
BR112015020851A2 (en) * 2013-02-21 2017-07-18 Massachusetts Inst Technology formulation for delivering an agent to a site in a mucosal cavity and method for delivering an agent to a site in a mucosal cavity.
US10842802B2 (en) 2013-03-15 2020-11-24 Medicis Pharmaceutical Corporation Controlled release pharmaceutical dosage forms
EP3129012A4 (en) 2014-04-08 2017-10-11 Teikoku Pharma USA, Inc. Rivastigmine transdermal compositions and methods of using the same
EP4013452A4 (en) * 2019-08-16 2023-10-18 AMD Pharma Ltd. Adhesive drug delivery film and a microparticle comprising thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4389397A (en) 1980-08-04 1983-06-21 Merck & Co., Inc. Solubilization of ivermectin in water
JPS6185315A (en) * 1984-10-04 1986-04-30 Teikoku Seiyaku Kk Sheet-like preparation
CA2018471A1 (en) * 1989-07-28 1991-01-28 Ian W. Kellaway Mucoadhesive hydrogels delivery system
US6245351B1 (en) * 1996-03-07 2001-06-12 Takeda Chemical Industries, Ltd. Controlled-release composition
WO1998022097A2 (en) * 1996-11-20 1998-05-28 Bio Advances, Llc Controlled release matrix composition using polar polymer or monomer and poly(acrylic acid) blend
US6153210A (en) * 1997-08-14 2000-11-28 Periodontix, Inc. Use of locally delivered metal ions for treatment of periodontal disease
PT1079813E (en) * 1998-04-29 2005-05-31 Virotex Corp PHARMACEUTICAL CARRIER TRANSPORTATION DEVICE SUITABLE FOR DELIVERY OF PHARMACEUTICAL COMPOUNDS TO MUCOUS SURFACES
US6800329B2 (en) * 1999-02-12 2004-10-05 Lts Lohmann Therapie-Systeme Ag Method for producing film-type dosage
US6375963B1 (en) * 1999-06-16 2002-04-23 Michael A. Repka Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof
DE19932603A1 (en) 1999-07-13 2001-01-25 Gruenenthal Gmbh Multi-layer film containing active substance made of in-situ cross-linked hydrophilic polymers
US6284235B1 (en) 2000-02-11 2001-09-04 National Starch And Chemical Company Investment Holding Corporation Bioadhesive composition
DE10146251A1 (en) 2001-09-20 2003-04-17 Gruenenthal Gmbh Device for producing a pharmaceutical film
US7846478B2 (en) 2002-01-31 2010-12-07 Henkel Ag & Co. Kgaa Bioadhesive composition
JP2003292554A (en) * 2002-04-08 2003-10-15 Hiroshi Takimoto Biodegradable compound, biodegradable composition and method for molding the same

Also Published As

Publication number Publication date
US20080286342A1 (en) 2008-11-20
EP1692216B1 (en) 2012-11-14
WO2005056648A1 (en) 2005-06-23
US8133510B2 (en) 2012-03-13
DE10358748A1 (en) 2005-07-14
CA2541779C (en) 2012-05-15
PL1692216T3 (en) 2013-04-30
CN100425639C (en) 2008-10-15
EP1692216A1 (en) 2006-08-23
CN1902266A (en) 2007-01-24
ES2397152T3 (en) 2013-03-05
JP5420150B2 (en) 2014-02-19
JP2007513917A (en) 2007-05-31

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Effective date: 20181213