CA2544612A1 - Degassing device and end-cap assembly for a filter including such a degassing device - Google Patents

Degassing device and end-cap assembly for a filter including such a degassing device Download PDF

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Publication number
CA2544612A1
CA2544612A1 CA002544612A CA2544612A CA2544612A1 CA 2544612 A1 CA2544612 A1 CA 2544612A1 CA 002544612 A CA002544612 A CA 002544612A CA 2544612 A CA2544612 A CA 2544612A CA 2544612 A1 CA2544612 A1 CA 2544612A1
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CA
Canada
Prior art keywords
chamber
degassing device
passageway
downstream portion
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002544612A
Other languages
French (fr)
Other versions
CA2544612C (en
Inventor
Juergen Dannenmaier
Hermann Goehl
Thomas Ertl
Jacques Chevallet
Francesco Ribolzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gambro Lundia AB
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2544612A1 publication Critical patent/CA2544612A1/en
Application granted granted Critical
Publication of CA2544612C publication Critical patent/CA2544612C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/21—Specific headers, end caps

Abstract

A degassing device (203) comprises a first chamber (21) having an inlet for a liquid, and a second chamber (22) having an opening (23) closed by a hydrophobic membrane (24) and an outlet (25) for discharging the liquid. The first chamber (21) has a downstream portion that partially extends within the second chamber (22) and communicates therewith by a passageway (28). The second chamber (22) has a downstream portion that extends below the passageway (28) and asymmetrically surrounds the downstream portion of the first chamber (21).

Claims (32)

1. A degassing device (201; 202; 203; 204; 205; 206) comprising:
- a first chamber (21) having an inlet for a liquid; and - a second chamber (22) having an opening (23) closed by a hydrophobic membrane (24) and an outlet (25) for discharging the liquid, wherein the first chamber (21) has a downstream portion that partially extends within the second chamber (22) and communicates therewith by a passageway (28), and the second chamber (22) has a downstream portion that extends below the passageway (28) and asymmetrically surrounds the downstream portion of the first chamber (21).
2. A degassing device (201; 202; 203; 204; 205; 206) according to claim 1, wherein the downstream portion of the second chamber (22) has a lateral wall (29;
62) that surrounds a longitudinal axis (27) of the degassing device and a bottom wall (30; 60) that is inclined with respect to a longitudinal axis (27) of the degassing device.
3. A degassing device (201; 202; 203; 204; 206) according to claim 2, wherein the downstream portion of the first chamber (21) has a lateral wall (26) that is concentric to the lateral wall (29) of the second chamber (22).
4. A degassing device (201; 202; 203; 204; 206) according to claims 3, wherein the lateral wall (26) of the downstream portion of the first chamber (21) and the lateral wall (29) of the downstream portion of the second chamber (22) are substantially cylindrical.
5. A degassing device (201; 202; 203; 204; 206) according to one of the claims to 4, wherein the downstream portion of the first chamber (21) has a cross-section that is substantially the same as the cross-section of the passageway (28) between the first and the second chamber (22).
6. A degassing device (205) according to one of the claims 1 and 2, wherein the downstream portion of the first chamber (21) is substantially conical and the passageway (28) between the first and the second chamber (22) opens at the tip of the cone.
7. A degassing device (205) according to claim 6, wherein the passageway (28) between the first and the second chamber (22) opens in the second chamber (22) close to a wall (62) delimiting an upstream portion of the second chamber (22).
8. A degassing device (201; 202; 205) according to one of the claims 1 to 7, wherein the first chamber (21) comprises an upstream portion having a decreasing cross section.
9. A degassing device (203; 204) according to one of the claims 1 to 7, wherein the first chamber (21) comprises an upstream portion having an increasing cross section.
10. A degassing device (201; 202; 203; 204; 206) according to one of the claims 1 to 9, wherein the second chamber (22) comprises an upstream portion extending above the passageway (28) that has a decreasing cross-section, with a larger cross-section that is substantially level with the passageway (28) and a smaller cross-section that is substantially level with the hydrophobic membrane (24).
11. A degassing device (201; 202; 203; 204) according to claim 10, wherein the upstream portion of the second chamber (22) is substantially frusto-conical.
12. A degassing device (201; 202; 203; 204; 205; 206) according to one of the claims 1 to 11, wherein the outlet port (25) opens in the downstream portion of the second chamber (22) at a location furthest to the passageway (28).
13. A degassing device (201; 202; 203; 204; 205; 206) according to one of the claims 1 to 12, wherein the ratio of the diameter of the passageway (28) to the diameter of the second chamber (22) at the level of the passageway (28) is comprised between about 0,2 and about 0,5.
14. A degassing device (201; 202; 203; 204; 205; 206) according to one of the claims 1 to 13, wherein the first chamber (21) of the degassing device has a downstream portion having a cross-section selected with respect to a maximal flow rate of a liquid in a circuit connected to the degassing device so that the velocity of the liquid in the downstream portion of the first chamber (21) is less than a predetermined velocity.
15. A degassing device (201; 202; 203; 204; 205; 206) according to claim 14, wherein the cross-section of the downstream portion of the first chamber (21) is selected with respect to a maximal flow rate of a liquid of about 500ml/min in a circuit connected to the degassing device so that the velocity of the liquid in the downstream portion of the first chamber (21) is less than about 3m/min.
16. A degassing device (201; 202; 203; 204; 205; 206) according to one of the claims 1 to 15, wherein the cross-section of the second chamber (22) of the degassing device at the level of the passageway (28) is selected so that the ratio of the velocity of a liquid within a downstream portion of the first chamber (21) to the velocity of the liquid within the second chamber (22) at the level of the passageway (28) is more than a determined value.
17. A degassing device (201; 202; 203; 204; 205; 206) according to claim 16, wherein the cross-section of the second chamber (22) of the degassing device at the level of the passageway (28) is selected so that the ratio of the velocity of the liquid within the downstream portion of the first chamber (21) to the velocity of the liquid within the second chamber (22) at the level of the passageway (28) is at least about 2.
18. A degassing device (201; 202; 203; 204; 205; 206) according to one of the claims 1 to 17, wherein the downstream portion of the second chamber (22) forms an overflow for a fluid flowing from the first chamber (21) into the second chamber (22).
19. A degassing device (201; 202; 203; 204; 205; 206) according to one of the claims 1 to 18, wherein the first chamber (21), the second chamber (22) and the passageway (28) therebetween are arranged with respect to each other so that a flow pattern of a liquid flowing from the first chamber (21), through the second chamber (22) and to the outlet port (25) comprises a component that is tangential to the membrane.
20. A degassing device (201; 202; 203; 204; 205; 206) according to claim 19, wherein the flow pattern of a liquid flowing from the first chamber (21), through the second chamber (22) and to the outlet port (25) comprises an umbrella like component.
21. A degassing device (201; 202; 203; 204; 205; 206) according to one of the claims 1 to 20, wherein the first chamber (21), the second chamber (22) and the passageway (28) therebetween are arranged with respect to each other so that a flow of liquid flowing from the first chamber (21), through the second chamber (22) and to the outlet port (25) keeps gas bubbles in motion along an inner surface of the hydrophobic membrane (24).
22. A degassing device (201) according to one of the claims 1 to 21, further comprising an inlet port (38, 39, 40) for the infusion of liquid.
23. A degassing device (201) according to one of the claims 1 to 22, further comprising a pressure measurement port (38, 39, 40) for connection to a pressure sensor.
24. A degassing device (201; 202; 203; 204; 205; 206) according to any of the claims 1 to 24, further comprising a protective member (36, 44, 59, 63, 77) for protecting the hydrophobic membrane (24) against external blows and for limiting the deformation of the hydrophobic membrane (24) when the pressure of the liquid within the degassing device exceeds a limit.
25. A degassing device (201; 202; 203; 204; 205; 206) according to one of the claims 1 to 24, wherein the hydrophobic membrane (24) is arranged in a plane substantially perpendicular to a longitudinal axis (27) of the degassing device.
26. End-cap assembly for a filtration device (1) including a filtration membrane (4) arranged in an elongated housing (2), the end-cap assembly comprising:
.cndot.an end-cap (5; 50) having:
- an end wall (15; 51) having a central axis, - a peripheral wall (16; 52; 61; 71) surrounding the end wall (15; 51), for connection to an end of the housing (2), and .cndot.a degassing device (201; 202; 203; 204; 205; 206) according to one of the claims 1 to 25 connected to the end-cap (5, 50) so that the first chamber (21) of the degassing chamber is in fluid communication with an interior of the en-cap.
27. End-cap assembly according to claim 26, wherein the degassing device (201;
202; 205; 206) has a longitudinal axis (27) that coincides with the central axis of the end wall (15; 60) of the end-cap (5) and the first chamber (21) has a wall (26;
60; 72) directly connected to the end wall (15; 60) of the end-cap (5).
28. End-cap assembly according to claim 27, wherein the end wall (15) of the end-cap (5) is substantially annular and the wall of the first chamber (21) has circular cross section decreasing from a first end of larger section, by which the first chamber (21) is connected to the end wall (15) of the end cap (5), to a second end of smaller cross section forming the passageway (28) between the first chamber (21) and the second chamber (22).
29. End-cap assembly according to claim 26, wherein the degassing device (203) has a longitudinal axis (27) that is substantially parallel to and spaced apart from the central axis (3) of the end wall (51) of the end-cap (50), and the end cap assembly further comprises a lateral nozzle (53) for connecting an interior of the end-cap (50) to an inlet (54) of the first chamber (21) of the degassing device (203).
30. End-cap assembly according to claim 29, wherein the first chamber (21) has a wall having circular cross section increasing from a first end of smaller section, which forms the inlet (54) of the first chamber (21), to a second end of larger cross section, which forms the passageway (28) between the first and the second chamber (22).
31. Filtration device (1) comprising an end-cap assembly according to one of the claims 26 to 30.
32. Filtration device (1) according to claim 31, for the extracorporeal treatment of blood.
CA2544612A 2003-11-24 2004-11-02 Degassing device and end-cap assembly for a filter including such a degassing device Expired - Fee Related CA2544612C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP03026855 2003-11-24
EP03026854.4 2003-11-24
EP03026854 2003-11-24
EP03026855.1 2003-11-24
PCT/EP2004/012372 WO2005053772A1 (en) 2003-11-24 2004-11-02 Degassing device and end-cap assembly for a filter including such a degassing device

Publications (2)

Publication Number Publication Date
CA2544612A1 true CA2544612A1 (en) 2005-06-16
CA2544612C CA2544612C (en) 2011-12-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2544612A Expired - Fee Related CA2544612C (en) 2003-11-24 2004-11-02 Degassing device and end-cap assembly for a filter including such a degassing device

Country Status (9)

Country Link
US (1) US8048209B2 (en)
EP (1) EP1532994B1 (en)
KR (1) KR101118380B1 (en)
CN (1) CN1878582B (en)
AU (1) AU2004294685B2 (en)
CA (1) CA2544612C (en)
ES (1) ES2476021T3 (en)
HK (1) HK1097783A1 (en)
WO (1) WO2005053772A1 (en)

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Publication number Publication date
AU2004294685B2 (en) 2010-07-08
US8048209B2 (en) 2011-11-01
KR101118380B1 (en) 2012-03-09
AU2004294685A1 (en) 2005-06-16
EP1532994B1 (en) 2014-04-09
EP1532994A1 (en) 2005-05-25
CN1878582A (en) 2006-12-13
KR20060120089A (en) 2006-11-24
ES2476021T3 (en) 2014-07-11
US20090084720A1 (en) 2009-04-02
WO2005053772A1 (en) 2005-06-16
HK1097783A1 (en) 2007-07-06
CN1878582B (en) 2011-05-25
CA2544612C (en) 2011-12-20

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