CA2547786A1 - Bulk compounder manifold - Google Patents

Bulk compounder manifold Download PDF

Info

Publication number
CA2547786A1
CA2547786A1 CA002547786A CA2547786A CA2547786A1 CA 2547786 A1 CA2547786 A1 CA 2547786A1 CA 002547786 A CA002547786 A CA 002547786A CA 2547786 A CA2547786 A CA 2547786A CA 2547786 A1 CA2547786 A1 CA 2547786A1
Authority
CA
Canada
Prior art keywords
manifold
outlet
fluid
check
valve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002547786A
Other languages
French (fr)
Other versions
CA2547786C (en
Inventor
Jeffrey Steigerwalt
Kenneth C. Raines
Richard S. Pierce
Aleandro Digianfilippo
Joel Bartholomew
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
B Braun Medical Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2547786A1 publication Critical patent/CA2547786A1/en
Application granted granted Critical
Publication of CA2547786C publication Critical patent/CA2547786C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/24—Check- or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A61M2039/1088—Tube connectors; Tube couplings having a plurality of male connectors, e.g. Luer connectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/04—Access sites having pierceable self-sealing members
    • A61M39/045—Access sites having pierceable self-sealing members pre-slit to be pierced by blunt instrument
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/87571—Multiple inlet with single outlet
    • Y10T137/87676—With flow control
    • Y10T137/87684—Valve in each inlet

Abstract

The present invention provides a manifold (10) for receiving fluid tubes in a bulk compounder. In its simplest form, the manifold includes a plurality of inlets, each inlet defining an opening to a respective fluid passageway, and each passageway contains a check-valve. Included in this manifold is an outl et (310) in fluid communication with the fluid passageways and an inlet port (140) which is coaxial with the outlet (310). The coaxial inlet port (140) contains a check-valve (150). Included as a part of the present invention is a cannula (300) adapted for use with the manifold of the present invention, tu be sets for use with the manifold of the present invention, and a method of minimizing error in filling a bag using a manifold in accordance with the present invention.

Claims (18)

1. A manifold for receiving fluid tubes in a bulk compounder, said manifold comprising:
a plurality of inlets, each inlet defining an opening to a respective fluid passageway, each said passageway containing a check-valve;
an outlet in fluid communication with said fluid passageways; and an inlet port which is coaxial with said outlet, said coaxial inlet port containing a check-valve.
2. The manifold of claim 1 further comprising a central chamber in fluid communication with each said fluid passageway for fluidly connecting said fluid passageways to said outlet.
3. The manifold of claim 1 wherein said outlet comprises an outlet port having a self-sealing membrane adapted to be penetrated by a cannula.
4. The manifold of claim 1 wherein said outlet comprises an outlet port having a self-sealing membrane adapted to be penetrated by a cannula, and wherein said coaxial inlet port check-valve is adapted to have a cracking pressure greater than the vacuum pressure within said outlet port when the cannula is pulled from said self-sealing membrane.
5. The manifold of claim 4 wherein all said check-valves are adapted to have a cracking pressure greater than the vacuum pressure within said outlet port when the cannula is pulled from said self-sealing membrane.
6. The manifold of claim 1 wherein said plurality of inlets are disposed linearly with respect to each other.
7. A manifold set for receiving fluid tubes in a bulk compounder comprising:
a manifold, said manifold comprising:
a plurality of inlets, each inlet defining an opening to a respective fluid passageway, each said passageway containing a check-valve;
an outlet in fluid communication with said fluid passageways; and an inlet port which is coaxial with said outlet, said coaxial inlet port containing a check-valve;
and a cannula having at least one male blunt tip for insertion into said self-sealing membrane.
8. The manifold set of claim 7 wherein said cannula has a female port at said male blunt tip end for receiving an additional male tip.
9. A manifold for receiving fluid tubes in a bulk compounder, said manifold comprising:
a plurality of inlets, each inlet defining an opening to a respective fluid passageway, each said passageway containing a check-valve, said plurality of inlets disposed radially from a center inlet; and an outlet in fluid communication with all of said fluid passageways and said center inlet;
said outlet and said center inlet having the same central axis.
10. The manifold of claim 9 wherein said center inlet defines a center passageway containing a check-valve.
11. A tube set for use in bulk compounding, said tube set comprising:
a plurality of pump sections, each said pump section having a distal end;
a plurality of tubes, each said tube of said plurality having a distal end and proximal end, each said proximal end of each tube of said plurality attached to said distal end of a respective pump section, and each said distal end of each tube of said plurality attached to a manifold, said manifold comprising:
a plurality of inlets, each inlet defining an opening to a respective fluid passageway, each said passageway containing a check-valve;
an outlet in fluid communication with said fluid passageways; and an inlet port which is coaxial with said outlet, said coaxial inlet port containing a check-valve.
12. The tube set of claim 11 wherein said plurality is six.
13. The tube set of claim 11 wherein said plurality is nine.
14. A tube set for use in bulk compounding, said tube set comprising:
a plurality of pump sections, each said pump section having a distal end and a proximal end;
a first plurality of tubes, each said tube of said first plurality attached to said proximal end of a respective pump section;
a second plurality of tubes, each said tube of said second plurality having a distal end and proximal end, each said proximal end of each tube of said second plurality attached to said distal end of a respective pump section, and said distal end of each tube of said second plurality attached to a manifold, said manifold comprising:
a plurality of inlets, each inlet defining an opening to a respective fluid passageway, each said passageway containing a check-valve;

an outlet in fluid communication with said fluid passageways; and an inlet port which is coaxial with said outlet, said coaxial inlet port containing a check-valve.
15. The tube set of claim 14 wherein said first and second plurality are both six.
16. The tube set of claim 14 wherein said first and second plurality are both nine.
17. A method of minimizing error in the filling of a product bag in a bulk compounding system, said method comprising the steps of:
providing a manifold with a minimum common volume to minimize residual holding of any one ingredient solution; and passing individual ingredient solutions through the manifold to fill a product bag;
whereby error is reduced because of the minimization of the manifold common volume step.
18. A cannula for attaching two fluid channels, said cannula comprising:
at least one male blunt tip end for insertion into a first fluid source; and a female port formed within said male blunt tip end to allow connection of said cannula to a different fluid source wherein said different fluid source has a male end.
CA2547786A 2003-12-04 2004-10-05 Bulk compounder manifold Expired - Fee Related CA2547786C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/727,930 2003-12-04
US10/727,930 US6951228B2 (en) 2003-12-04 2003-12-04 Bulk compounder manifold
PCT/US2004/032668 WO2005061328A1 (en) 2003-12-04 2004-10-05 Bulk compounder manifold

Publications (2)

Publication Number Publication Date
CA2547786A1 true CA2547786A1 (en) 2005-07-07
CA2547786C CA2547786C (en) 2011-05-10

Family

ID=34633591

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2547786A Expired - Fee Related CA2547786C (en) 2003-12-04 2004-10-05 Bulk compounder manifold

Country Status (9)

Country Link
US (3) US6951228B2 (en)
EP (1) EP1689641B1 (en)
JP (2) JP4538004B2 (en)
CN (1) CN100577520C (en)
AU (1) AU2004305480B2 (en)
CA (1) CA2547786C (en)
ES (1) ES2539797T3 (en)
HK (1) HK1090009A1 (en)
WO (1) WO2005061328A1 (en)

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Also Published As

Publication number Publication date
EP1689641B1 (en) 2015-04-08
JP2010148963A (en) 2010-07-08
WO2005061328A1 (en) 2005-07-07
EP1689641A4 (en) 2010-09-29
US6951228B2 (en) 2005-10-04
CN100577520C (en) 2010-01-06
US20060070684A1 (en) 2006-04-06
CA2547786C (en) 2011-05-10
CN1997553A (en) 2007-07-11
US7036537B2 (en) 2006-05-02
HK1090009A1 (en) 2006-12-15
ES2539797T3 (en) 2015-07-06
JP5188531B2 (en) 2013-04-24
BRPI0416543A (en) 2007-01-09
JP2007515207A (en) 2007-06-14
US20050126652A1 (en) 2005-06-16
WO2005061328A8 (en) 2005-09-22
AU2004305480B2 (en) 2009-12-03
US7252122B2 (en) 2007-08-07
EP1689641A1 (en) 2006-08-16
US20050121103A1 (en) 2005-06-09
JP4538004B2 (en) 2010-09-08
AU2004305480A1 (en) 2005-07-07

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Effective date: 20211005