CA2552717A1 - Mixing bag with integral sparger and sensor receiver - Google Patents

Mixing bag with integral sparger and sensor receiver Download PDF

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Publication number
CA2552717A1
CA2552717A1 CA002552717A CA2552717A CA2552717A1 CA 2552717 A1 CA2552717 A1 CA 2552717A1 CA 002552717 A CA002552717 A CA 002552717A CA 2552717 A CA2552717 A CA 2552717A CA 2552717 A1 CA2552717 A1 CA 2552717A1
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CA
Canada
Prior art keywords
fluid
bag
vessel
receiving
receiver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002552717A
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French (fr)
Other versions
CA2552717C (en
Inventor
Alexandre N. Terentiev
Sergey Terentyev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Levtech Inc
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Individual
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Filing date
Publication date
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Application filed by Individual filed Critical Individual
Publication of CA2552717A1 publication Critical patent/CA2552717A1/en
Application granted granted Critical
Publication of CA2552717C publication Critical patent/CA2552717C/en
Expired - Fee Related legal-status Critical Current
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/513—Flexible receptacles, e.g. bags supported by rigid containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/231—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids by bubbling
    • B01F23/23105—Arrangement or manipulation of the gas bubbling devices
    • B01F23/2312—Diffusers
    • B01F23/23121—Diffusers having injection means, e.g. nozzles with circumferential outlet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/231—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids by bubbling
    • B01F23/23105—Arrangement or manipulation of the gas bubbling devices
    • B01F23/2312—Diffusers
    • B01F23/23123—Diffusers consisting of rigid porous or perforated material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/808—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with stirrers driven from the bottom of the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B01F33/4534—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements using a rod for supporting the stirring element, e.g. stirrer sliding on a rod or mounted on a rod sliding in a tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/213—Measuring of the properties of the mixtures, e.g. temperature, density or colour
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers

Abstract

A mixing bag (10) for use in bioprocessing in which a fluid (F) is received and agitated using an internal fluid-agitating element (18) driven by an external motive device (24). The bag (10) may include an integral sparger (100) and sensor receiver (200).

Claims (35)

1. A bioprocessing vessel intended for receiving a fluid, comprising:
a bag capable of receiving and holding the fluid, the bag having a rigid, integral sparger including means for forming bubbles from a gas supplied to the fluid in the bag.
2. The vessel according to claim 1, wherein the rigid, integral sparger is welded to the bag to form a fluid-impervious seal.
3. The vessel according to claim 2, wherein the means for forming bubbles comprises a perforated film attached to the rigid material.
4. The vessel according to claim 2, wherein the means for forming bubbles comprises a gas permeable film attached to the rigid material.
5. The vessel according to claim 2, wherein the means for forming bubbles comprises a perforated piece of material attached to a face of the sparger along the interior of the bag.
6. The vessel according to claims 1, further including a magnetic fluid-agitating element.
7. The vessel according to claim 6, wherein the rigid material further includes a first receiver for receiving and holding the magnetic fluid-agitating element at a home location when positioned in the vessel.
8. The vessel according to claim 6, wherein the receiver is an upstanding post.
9. The vessel according to claim 1, wherein the sparger comprises a rigid material, and the means for forming bubbles comprises an outer wall of a post connected to the rigid material, wherein the post provides a centering function for an annular magnetic fluid-agitating element positioned in the bag.
10. The vessel according to claim 9, wherein the post includes an oversized head for retaining the fluid-agitating element.
11. The vessel according to claim 9, wherein the rigid material includes a recess for receiving a motive device for the fluid-agitating element.
12. A bioprocessing vessel intended for receiving a fluid, comprising:
a bag capable of receiving and holding the fluid, the bag having a rigid receiver facing an interior; and an at least translucent tube having a closed end for insertion through the receiver and in communication with the interior.
13. The vessel of claim 12, further including a magnetic fluid-agitating element.
14. The vessel of claim 12, wherein the rigid receiver is welded to the bag to form a fluid-impervious seal.
15. The vessel of claim 12, further including a bushing for holding the receiver in the tube.
16. The vessel of claim 12, further including means for sealing the tube in the receiver.
17. The vessel of claim 12, further including a fluorescent sensor element externally attached to the closed end of the tube.
18. The vessel of claim 17, in combination with a fiber optic cable for transmitting light to the sensor element and receiving the light reflected therefrom.
19. A bioprocessing vessel intended for receiving a fluid, comprising:
a bag capable of receiving and holding the fluid, the bag having an integral sparger including a perforated or gas permeable material for forming bubbles from a gas supplied to the fluid; and a magnetic element for agitating the fluid.
20. The vessel of claim 19, further including a rigid receiver for receiving the magnetic element in the bag.
21 21. The vessel of claim 20, wherein the receiver is a post and the material comprises an outer wall of the post.
22. The vessel of claim 20, wherein the sparger comprises a rigid portion welded to the bag and the material comprises a porous or permeable film attached to the face of the portion.
23. A bioprocessing vessel intended for receiving a fluid, comprising:
a bag capable of receiving and holding the fluid, the bag having a rigid receiver facing an interior;
an at least translucent tube having a closed end for insertion through the receiver and in communication with the interior; and a magnetic fluid-agitating element.
24. The vessel of claim 23, further including a rigid receiver for receiving the magnetic element in the bag.
25. A method of manufacturing a bioreactor, comprising:
providing a bag capable of receiving and holding a fluid; and attaching to the bag an integral sparger including means for forming bubbles from a gas supplied to the fluid in the bag.
26. The method of claim 25, wherein the sparger comprises a rigid, disk-shaped piece of material, and the attaching step comprises welding the bag to the periphery of the rigid material to form a fluid-impervious seal.
27. The method of claim 25, further including the step of placing a magnetic impeller in the bag.
28. A method of bioprocessing a fluid, comprising:
providing a bag capable of receiving and holding a fluid;
attaching to the bag a rigid, integral sparger including means for forming bubbles in the fluid when present;
supplying gas to the sparger; and disposing of the bag, including the sparger.
29. The method of claim 28, further including the step of recovering the fluid from the bag.
30. The method of claim 28, wherein the step of attaching comprises welding the bag to the rigid material to create a fluid-impervious seal.
31. The method of claim 28, further including the step of agitating the fluid using an externally driven magnetic fluid-agitating element.
32. A method of arranging a sensor for a fluid bioprocessing operation, comprising:
providing a bag capable of receiving and holding a fluid;
attaching to the bag a rigid receiver; and inserting a transparent tube having a closed end in the receiver, whereby the sensor may be positioned on or in the tube for interfacing with the fluid.
in the bag.
33. The method of claim 32, further comprising the steps of disposing of the bag with the tube in the receiver.
34. The method of claim 32, further comprising the step of inserting a fiber optic cable in an open end of the tube.
35. The method of claim 32, further comprising externally attaching a fluorescent sensor element to a closed end of the tube.
CA2552717A 2004-01-07 2005-01-07 Mixing bag with integral sparger and sensor receiver Expired - Fee Related CA2552717C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US53503104P 2004-01-07 2004-01-07
US60/535,031 2004-01-07
US59996004P 2004-08-09 2004-08-09
US60/599,960 2004-08-09
PCT/US2005/000464 WO2005068059A1 (en) 2004-01-07 2005-01-07 Mixing bag with integral sparger and sensor receiver

Publications (2)

Publication Number Publication Date
CA2552717A1 true CA2552717A1 (en) 2005-07-28
CA2552717C CA2552717C (en) 2011-11-29

Family

ID=34798840

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2552717A Expired - Fee Related CA2552717C (en) 2004-01-07 2005-01-07 Mixing bag with integral sparger and sensor receiver

Country Status (6)

Country Link
US (7) US7469884B2 (en)
EP (2) EP2813281B1 (en)
JP (1) JP2007522801A (en)
CA (1) CA2552717C (en)
IL (1) IL176667A (en)
WO (1) WO2005068059A1 (en)

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US20060131765A1 (en) 2006-06-22
US20070252290A1 (en) 2007-11-01
EP2813281A1 (en) 2014-12-17
WO2005068059A1 (en) 2005-07-28
CA2552717C (en) 2011-11-29
US9770696B2 (en) 2017-09-26
EP1701780B8 (en) 2014-09-24
US20090135667A1 (en) 2009-05-28
US20100197003A1 (en) 2010-08-05
JP2007522801A (en) 2007-08-16
US20120152769A1 (en) 2012-06-21
US8123199B2 (en) 2012-02-28
US7384027B2 (en) 2008-06-10
US8708319B2 (en) 2014-04-29
US7469884B2 (en) 2008-12-30
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EP1701780A1 (en) 2006-09-20
IL176667A0 (en) 2006-10-31
US20130171723A1 (en) 2013-07-04
US20140234951A1 (en) 2014-08-21
US7992846B2 (en) 2011-08-09
EP2813281B1 (en) 2016-08-17
US8550439B2 (en) 2013-10-08
EP1701780A4 (en) 2011-11-23

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