CA2567839A1 - Mass spectrometry with selective ion filtration by digital thresholding - Google Patents
Mass spectrometry with selective ion filtration by digital thresholding Download PDFInfo
- Publication number
- CA2567839A1 CA2567839A1 CA002567839A CA2567839A CA2567839A1 CA 2567839 A1 CA2567839 A1 CA 2567839A1 CA 002567839 A CA002567839 A CA 002567839A CA 2567839 A CA2567839 A CA 2567839A CA 2567839 A1 CA2567839 A1 CA 2567839A1
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- Prior art keywords
- mass spectrometer
- digital
- digital signal
- threshold
- digitizer
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Classifications
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0009—Calibration of the apparatus
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
Abstract
The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly- or multiply-charged ions by selective ion filtering carried out by a digital thresholding process.
Claims (32)
1. A method of identifying a multiply-charged ion comprising:
a) specifying a digital signal threshold on a mass spectrometer, wherein the mass spectrometer comprises:
i) an ion detector;
ii) a digitizer for converting an analog signal to a digital signal;
iii) an analog signal transfer means for transferring an analog signal from the detector to the digitizer; and iv) a digital threshold filter, for setting a digital signal threshold, in digital data communication with the digitizer, in response to a digital signal input from the digitizer, independently outputting a digital signal to a data file only if the digital signal input is greater than the specified digital signal threshold;
wherein upon a mass spectrometer measurement of the multiply-charged ion, the filtered digital signal output to the data file originates from the detection of the multiply-charged ion and excludes digital signal output from analog signals arising from singly-charged ions.
a) specifying a digital signal threshold on a mass spectrometer, wherein the mass spectrometer comprises:
i) an ion detector;
ii) a digitizer for converting an analog signal to a digital signal;
iii) an analog signal transfer means for transferring an analog signal from the detector to the digitizer; and iv) a digital threshold filter, for setting a digital signal threshold, in digital data communication with the digitizer, in response to a digital signal input from the digitizer, independently outputting a digital signal to a data file only if the digital signal input is greater than the specified digital signal threshold;
wherein upon a mass spectrometer measurement of the multiply-charged ion, the filtered digital signal output to the data file originates from the detection of the multiply-charged ion and excludes digital signal output from analog signals arising from singly-charged ions.
2. The method of claim 1 further comprising making a plurality of mass spectrometer measurements according to step a) and co-adding the resulting plurality of data files.
3. The method of claim 1 wherein the multiply-charged ion is a biomolecule.
4. The method of claim 3 wherein the biomolecule is a nucleic acid, peptide, protein, lipid, or carbohydrate.
5. The method of claim 3 wherein the biomolecule comprises a non-covalently-bound small molecule.
6. The method of claim 1 wherein the singly-charged ions are biomolecule stabilizer additives or matrix modifiers.
7. The method of claim 6 wherein the stabilizer additives are one or more of:
polyethylene glycol, glycerol, reducing agents, detergents or buffer salts, or any combination thereof.
polyethylene glycol, glycerol, reducing agents, detergents or buffer salts, or any combination thereof.
8. The method of claim 6 wherein the matrix-modifying additives are one or more of:
ampholytes, detergents, or buffer salts, or any combination thereof.
ampholytes, detergents, or buffer salts, or any combination thereof.
9. The method of claim 1 wherein the analog signal is an analog voltage signal and the digital signal is a digital voltage signal.
10. The method of claim 1 wherein the mass spectrometer is a time-of-flight mass spectrometer, a quadrupole time-of-flight mass spectrometer, a linear quadrupole mass spectrometer, a linear trap mass spectrometer, an electric/magnetic sector mass spectrometer, or a quadrupole ion trap mass spectrometer.
11. A method for determining the molecular mass of a plurality of analytes in a mixture comprising:
a) specifying a unique digital signal threshold for at least some members of a plurality of digital threshold filters on a mass spectrometer, wherein the mass spectrometer comprises:
i) an ion detector;
ii) a digitizer for converting an analog signal to a digital signal;
iii) an analog signal transfer means for transferring an analog signal from the detector to the digitizer; and iv) a plurality of digital threshold filters for setting a digital signal threshold in digital data communication with the digitizer, in response to a digital signal input from the digitizer independently outputting a digital signal to a corresponding data file only if the digital signal input is greater than the specified digital signal threshold;
b) making a mass spectrometer measurement of the mixture, wherein each unique digital signal threshold differentially filters digital signals arising from the plurality of analytes and produces a unique digital signal output to each corresponding data file wherein the measurement results in storage of a plurality of data files; and c) analyzing each member of the plurality of data files wherein the molecular mass of at least one member of the plurality of analytes is contained therein.
a) specifying a unique digital signal threshold for at least some members of a plurality of digital threshold filters on a mass spectrometer, wherein the mass spectrometer comprises:
i) an ion detector;
ii) a digitizer for converting an analog signal to a digital signal;
iii) an analog signal transfer means for transferring an analog signal from the detector to the digitizer; and iv) a plurality of digital threshold filters for setting a digital signal threshold in digital data communication with the digitizer, in response to a digital signal input from the digitizer independently outputting a digital signal to a corresponding data file only if the digital signal input is greater than the specified digital signal threshold;
b) making a mass spectrometer measurement of the mixture, wherein each unique digital signal threshold differentially filters digital signals arising from the plurality of analytes and produces a unique digital signal output to each corresponding data file wherein the measurement results in storage of a plurality of data files; and c) analyzing each member of the plurality of data files wherein the molecular mass of at least one member of the plurality of analytes is contained therein.
12. The method of claim 11 further comprising making a plurality of mass spectrometer measurements according to step b) and co-adding the resulting plurality of data files obtained from the plurality of mass spectrometer measurements.
13. The method of claim 11 wherein the analysis of step c) comprises mathematical subtraction of at least one member of the plurality of data files from at least one other member of the plurality of data files.
14. The method of claim 11 wherein the plurality of analytes comprise singly-charged ions and multiply-charged ions.
15. The method of claim 14 wherein the multiply-charged ions are biomolecules.
16. The method of claim 15 wherein the biomolecules comprise non-covalently-bound small molecules.
17. The method of claim 15 wherein the biomolecules are nucleic acids, peptides, proteins, lipids or carbohydrates.
18. The method of claim 14 wherein the singly-charged ions are biomolecule stabilizer additives or matrix modifiers.
19. The method of claim 18 wherein the stabilizer additives are one or more of:
polyethylene glycol, glycerol, reducing agents, detergents, or buffer salts, or any combination thereof.
polyethylene glycol, glycerol, reducing agents, detergents, or buffer salts, or any combination thereof.
20. The method of claim 18 wherein the matrix-modifying additives are one or more of:
ampholytes, detergents, or buffer salts, or any combination thereof.
ampholytes, detergents, or buffer salts, or any combination thereof.
21. The method of claim 11 wherein the analog signal is an analog voltage signal and the digital signal is a digital voltage signal.
22. The method of claim 11 wherein the mass spectrometer is a time-of-flight mass spectrometer, a quadrupole time-of-flight mass spectrometer, a linear quadrupole mass spectrometer, a linear trap mass spectrometer, an electric/magnetic sector mass spectrometer, or a quadrupole ion trap mass spectrometer.
23. A method of calibrating a mass spectrum of an analyte comprising:
a) specifying a first digital signal threshold at a first member of a plurality of digital threshold filters, on a mass spectrometer, wherein the mass spectrometer comprises:
i) an ion detector;
ii) a digitizer for converting an analog signal to a digital signal;
iii) an analog signal transfer means for transferring an analog signal from the detector to the digitizer; and iv) a plurality of digital threshold filters for setting a digital signal threshold, in digital data communication with the digitizer, in response to a digital signal input from the digitizer, independently outputting a digital signal to a corresponding data file only if the digital signal input is greater than the specified digital signal threshold;
wherein the first digital signal threshold is specified such that digital signal output to a first data file comprises signals from the analyte and a calibrant ion;
b) specifying a second digital signal threshold at a second member of the plurality of digital threshold filters wherein the second digital signal threshold is specified such that digital signal output to a second data file comprises signals from the analyte but not from the calibrant ion;
c) subtracting the second data file from the first data file to obtain a calibration data file comprising a signal from the calibrant ion but not from the analyte; and d) using said calibration data file to calibrate the mass spectrum of the analyte.
a) specifying a first digital signal threshold at a first member of a plurality of digital threshold filters, on a mass spectrometer, wherein the mass spectrometer comprises:
i) an ion detector;
ii) a digitizer for converting an analog signal to a digital signal;
iii) an analog signal transfer means for transferring an analog signal from the detector to the digitizer; and iv) a plurality of digital threshold filters for setting a digital signal threshold, in digital data communication with the digitizer, in response to a digital signal input from the digitizer, independently outputting a digital signal to a corresponding data file only if the digital signal input is greater than the specified digital signal threshold;
wherein the first digital signal threshold is specified such that digital signal output to a first data file comprises signals from the analyte and a calibrant ion;
b) specifying a second digital signal threshold at a second member of the plurality of digital threshold filters wherein the second digital signal threshold is specified such that digital signal output to a second data file comprises signals from the analyte but not from the calibrant ion;
c) subtracting the second data file from the first data file to obtain a calibration data file comprising a signal from the calibrant ion but not from the analyte; and d) using said calibration data file to calibrate the mass spectrum of the analyte.
24. The method of claim 23 wherein the calibrant ion is a nucleic acid, peptide or small molecule.
25. The method of claim 23 wherein the analyte is a biomolecule.
26. The method of claim 25 wherein the biomolecule is a nucleic acid, peptide, protein, lipid or carbohydrate.
27. The method of claim 26 wherein the biomolecule comprises a non-covalently-bound small molecule.
28. The method of claim 23 wherein the analog signal is an analog voltage signal and the digital signal is a digital voltage signal.
29. The method of claim 23 wherein the mass spectrometer is a time-of-flight mass spectrometer, a quadrupole time-of-flight mass spectrometer, a linear quadrupole mass spectrometer, a linear trap mass spectrometer, an electric/magnetic sector mass spectrometer, or a quadrupole ion trap mass spectrometer.
30. A system comprising a mass spectrometer comprising:
an ion detector;
a digitizer for converting an analog signal to a digital signal;
an analog signal transfer means for transferring an analog signal from the detector to the digitizer;
a plurality of digital threshold filters for setting a plurality of independent digital signal thresholds, each digital threshold filter in parallel electronic communication with the digitizer, each digital threshold filter in response to a digital voltage input from the digitizer independently outputting a digital voltage only if the digital voltage input is greater than the specified digital signal threshold;
a plurality of data files; and a plurality of parallel digital signal output transferring means, each of which is in digital data communication with one of the digital threshold filters and a corresponding data file from the plurality of data files.
an ion detector;
a digitizer for converting an analog signal to a digital signal;
an analog signal transfer means for transferring an analog signal from the detector to the digitizer;
a plurality of digital threshold filters for setting a plurality of independent digital signal thresholds, each digital threshold filter in parallel electronic communication with the digitizer, each digital threshold filter in response to a digital voltage input from the digitizer independently outputting a digital voltage only if the digital voltage input is greater than the specified digital signal threshold;
a plurality of data files; and a plurality of parallel digital signal output transferring means, each of which is in digital data communication with one of the digital threshold filters and a corresponding data file from the plurality of data files.
31. The system of claim 30 wherein the analog signal is an analog voltage signal and the digital signal is a digital voltage signal.
32. The system of claim 30 wherein the mass spectrometer is a time-of-flight mass spectrometer, a quadrupole time-of-flight mass spectrometer, a linear quadrupole mass spectrometer, a linear trap mass spectrometer, an electric/magnetic sector mass spectrometer, or a quadrupole ion trap mass spectrometer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57404204P | 2004-05-24 | 2004-05-24 | |
| US60/574,042 | 2004-05-24 | ||
| PCT/US2005/018337 WO2005117270A2 (en) | 2004-05-24 | 2005-05-24 | Mass spectrometry with selective ion filtration by digital thresholding |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2567839A1 true CA2567839A1 (en) | 2005-12-08 |
| CA2567839C CA2567839C (en) | 2011-06-28 |
Family
ID=35451565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2567839A Expired - Fee Related CA2567839C (en) | 2004-05-24 | 2005-05-24 | Mass spectrometry with selective ion filtration by digital thresholding |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US7714275B2 (en) |
| EP (2) | EP2458619B1 (en) |
| JP (1) | JP4810533B2 (en) |
| CA (1) | CA2567839C (en) |
| ES (1) | ES2641832T3 (en) |
| WO (1) | WO2005117270A2 (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8097416B2 (en) | 2003-09-11 | 2012-01-17 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
| US8546082B2 (en) | 2003-09-11 | 2013-10-01 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
| US20120122103A1 (en) | 2003-09-11 | 2012-05-17 | Rangarajan Sampath | Compositions for use in identification of bacteria |
| EP2458619B1 (en) * | 2004-05-24 | 2017-08-02 | Ibis Biosciences, Inc. | Mass spectrometry with selective ion filtration by digital thresholding |
| US8076104B2 (en) * | 2007-01-25 | 2011-12-13 | Rogan Peter K | Rapid and comprehensive identification of prokaryotic organisms |
| US7811766B2 (en) | 2007-03-28 | 2010-10-12 | Thinkvillage, Llc | Genetic identification and validation of Echinacea species |
| US8527207B2 (en) * | 2007-05-15 | 2013-09-03 | Peter K. Rogan | Accurate identification of organisms based on individual information content |
| US7977626B2 (en) * | 2007-06-01 | 2011-07-12 | Agilent Technologies, Inc. | Time of flight mass spectrometry method and apparatus |
| WO2008151023A2 (en) | 2007-06-01 | 2008-12-11 | Ibis Biosciences, Inc. | Methods and compositions for multiple displacement amplification of nucleic acids |
| JP5251232B2 (en) * | 2008-04-25 | 2013-07-31 | 株式会社島津製作所 | Mass spectrometry data processing method and mass spectrometer |
| US9393564B2 (en) | 2009-03-30 | 2016-07-19 | Ibis Biosciences, Inc. | Bioagent detection systems, devices, and methods |
| US20110171619A1 (en) * | 2009-05-28 | 2011-07-14 | Daniel Leo Sweeney | Representation of molecules as sets of masses of complementary subgroups and contiguous complementary subgroups |
| WO2011014811A1 (en) | 2009-07-31 | 2011-02-03 | Ibis Biosciences, Inc. | Capture primers and capture sequence linked solid supports for molecular diagnostic tests |
| ES2628739T3 (en) | 2009-10-15 | 2017-08-03 | Ibis Biosciences, Inc. | Multiple displacement amplification |
| EP2545183B1 (en) | 2010-03-10 | 2017-04-19 | Ibis Biosciences, Inc. | Production of single-stranded circular nucleic acid |
| US9068017B2 (en) | 2010-04-08 | 2015-06-30 | Ibis Biosciences, Inc. | Compositions and methods for inhibiting terminal transferase activity |
| CA2819024C (en) * | 2010-12-17 | 2016-07-12 | Thermo Fisher Scientific (Bremen) Gmbh | Data acquisition system and method for mass spectrometry |
| EP2753629B1 (en) | 2011-09-06 | 2016-10-19 | Ibis Biosciences, Inc. | Methods for detecting lyme disease |
| US9970061B2 (en) | 2011-12-27 | 2018-05-15 | Ibis Biosciences, Inc. | Bioagent detection oligonucleotides |
| CN104937390B (en) | 2012-09-26 | 2018-09-21 | 艾比斯生物科学公司 | swab interface for microfluidic device |
| WO2016004542A1 (en) * | 2014-07-09 | 2016-01-14 | Tofwerk Ag | Device for mass spectrometry |
| GB2559145B (en) | 2017-01-26 | 2022-07-13 | Micromass Ltd | Method of separating different ions having similar mass to charge ratios |
| EP3389080A1 (en) * | 2017-04-10 | 2018-10-17 | Tofwerk AG | Ion source and method for generating elemental ions from aerosol particles |
| US11848181B2 (en) * | 2019-01-31 | 2023-12-19 | Dh Technologies Development Pte. Ltd. | Acquisition strategy for top-down analysis with reduced background and peak overlapping |
| US11315775B2 (en) | 2020-01-10 | 2022-04-26 | Perkinelmfr Health Sciences Canada, Inc. | Variable discriminator threshold for ion detection |
Family Cites Families (431)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4075475A (en) | 1976-05-03 | 1978-02-21 | Chemetron Corporation | Programmed thermal degradation-mass spectrometry analysis method facilitating identification of a biological specimen |
| US5641631A (en) | 1983-01-10 | 1997-06-24 | Gen-Probe Incorporated | Method for detecting, identifying, and quantitating organisms and viruses |
| US5288611A (en) * | 1983-01-10 | 1994-02-22 | Gen-Probe Incorporated | Method for detecting, identifying, and quantitating organisms and viruses |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| DE3752172T3 (en) | 1986-11-24 | 2008-04-10 | Gen-Probe Inc., San Diego | Nucleic acid probes for the detection and / or quantitation of non-viral organisms |
| WO1988006633A1 (en) | 1987-03-02 | 1988-09-07 | Arnold Lyle John Jr | Polycationic supports for nucleic acid purification, separation and hybridization |
| US5188963A (en) | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
| US5270030A (en) | 1988-12-29 | 1993-12-14 | Bio-Technology General Corp. | Fibrin binding domain polypeptide and method of producing |
| US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
| DE69022180T2 (en) | 1989-05-31 | 1996-02-01 | Amoco Corp | UNIVERSAL NUCLEIC ACID PROBE FOR EUBACTERIA AND METHODS. |
| US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5213961A (en) | 1989-08-31 | 1993-05-25 | Brigham And Women's Hospital | Accurate quantitation of RNA and DNA by competetitive polymerase chain reaction |
| US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
| US5143905A (en) | 1990-05-03 | 1992-09-01 | The Regents Of The University Of California | Method and means for extending the host range of insecticidal proteins |
| US5015845A (en) | 1990-06-01 | 1991-05-14 | Vestec Corporation | Electrospray method for mass spectrometry |
| US4996423A (en) * | 1990-06-04 | 1991-02-26 | Paradygm Science & Technologies, Inc. | Chop mode operated mass spectrometer for reducing the effect of line signals |
| US5712125A (en) | 1990-07-24 | 1998-01-27 | Cemv Bioteknik Ab | Competitive PCR for quantitation of DNA |
| DE4030262A1 (en) | 1990-09-25 | 1992-03-26 | Suedzucker Ag | METHOD FOR PRODUCING RHAMNOSE FROM RHAMNOLIPID |
| NL9002259A (en) | 1990-10-17 | 1992-05-18 | Eurodiagnostics B V | METHOD FOR DETERMINING A GENOTYPE BY COMPARING THE NUCLEOTID SEQUENCE OF MEM FAMILY MEMBERS AND KIT FOR DETECTING GENETIC VARIATIONS. |
| WO1992009703A1 (en) | 1990-11-26 | 1992-06-11 | Cbr Laboratories, Inc. | Testing for spirochetal nucleic acid sequences in samples |
| US5072115A (en) * | 1990-12-14 | 1991-12-10 | Finnigan Corporation | Interpretation of mass spectra of multiply charged ions of mixtures |
| WO1992013629A1 (en) | 1991-01-31 | 1992-08-20 | Wayne State University | A method for analyzing an organic sample |
| US5866429A (en) | 1991-04-03 | 1999-02-02 | Bloch; Will | Precision and accuracy of anion-exchange separation of nucleic acids |
| US5472843A (en) | 1991-04-25 | 1995-12-05 | Gen-Probe Incorporated | Nucleic acid probes to Haemophilus influenzae |
| US5213796A (en) | 1991-05-06 | 1993-05-25 | Dana Farber Cancer Institute | Assay for polyomavirus in humans and uses thereof |
| US6055487A (en) | 1991-07-30 | 2000-04-25 | Margery; Keith S. | Interactive remote sample analysis system |
| CA2116543C (en) | 1991-07-31 | 2007-10-02 | Kay S. Greisen | Methods and reagents for detection of bacteria in cerebrospinal fluid |
| ATE257860T1 (en) | 1991-08-02 | 2004-01-15 | Biomerieux Bv | QUANTIFICATION OF NUCLEIC ACIDS |
| ATE241704T1 (en) | 1991-08-27 | 2003-06-15 | Hoffmann La Roche | PRIMERS AND BUT FOR DETECTING HEPATITIS C |
| WO1993005182A1 (en) | 1991-09-05 | 1993-03-18 | Isis Pharmaceuticals, Inc. | Determination of oligonucleotides for therapeutics, diagnostics and research reagents |
| EP0610396B1 (en) | 1991-10-23 | 2001-01-17 | Baylor College Of Medicine | Fingerprinting bacterial strains using repetitive dna sequence amplification |
| FR2683827B1 (en) | 1991-11-15 | 1994-03-04 | Institut Nal Sante Recherc Medic | METHOD FOR DETERMINING THE QUANTITY OF A FRAGMENT OF DNA OF INTEREST BY AN ENZYMATIC AMPLIFICATION METHOD. |
| US6235887B1 (en) | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
| US5484908A (en) | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
| ATE226093T1 (en) | 1991-11-26 | 2002-11-15 | Isis Pharmaceuticals Inc | INCREASED FORMATION OF TRIPLE AND DOUBLE HELICES FROM OLIGOMERS WITH MODIFIED PYRIMIDINES |
| TW393513B (en) | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| IL103935A0 (en) | 1991-12-04 | 1993-05-13 | Du Pont | Method for the identification of microorganisms by the utilization of directed and arbitrary dna amplification |
| AU3794893A (en) | 1992-03-13 | 1993-10-05 | Park Scientific Instruments Corp. | Scanning probe microscope |
| US5981176A (en) | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
| US6303297B1 (en) | 1992-07-17 | 2001-10-16 | Incyte Pharmaceuticals, Inc. | Database for storage and analysis of full-length sequences |
| FR2694754B1 (en) | 1992-08-12 | 1994-09-16 | Bio Merieux | Mycobacteria DNA fragments, amplification primers, hybridization probes, reagents and method for detecting detection of mycobacteria. |
| AU5128593A (en) | 1992-09-16 | 1994-04-12 | University Of Tennessee Research Corporation, The | Antigen of hybrid m protein and carrier for group a streptococcal vaccine |
| AU5298393A (en) | 1992-10-08 | 1994-05-09 | Regents Of The University Of California, The | Pcr assays to determine the presence and concentration of a target |
| US6436635B1 (en) | 1992-11-06 | 2002-08-20 | Boston University | Solid phase sequencing of double-stranded nucleic acids |
| US5503980A (en) | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| US6372424B1 (en) | 1995-08-30 | 2002-04-16 | Third Wave Technologies, Inc | Rapid detection and identification of pathogens |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US6194144B1 (en) | 1993-01-07 | 2001-02-27 | Sequenom, Inc. | DNA sequencing by mass spectrometry |
| EP1262564A3 (en) | 1993-01-07 | 2004-03-31 | Sequenom, Inc. | Dna sequencing by mass spectrometry |
| FR2701961B1 (en) | 1993-02-24 | 1995-04-21 | Bio Merieux | Method for destabilizing an intracatenary secondary structure of a single-stranded polynucleotide, and for capturing said nucleotide. |
| AU687801B2 (en) | 1993-03-19 | 1998-03-05 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| US6074823A (en) | 1993-03-19 | 2000-06-13 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| US5639606A (en) | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| US6323041B1 (en) * | 1993-06-11 | 2001-11-27 | Pfizer Inc. | Screening novel human phosphodiesterase IV isozymes for compounds which modify their enzymatic activity |
| JPH0775585A (en) | 1993-06-14 | 1995-03-20 | Immuno Japan:Kk | Hepatitis c virus-related oligonucleotide and method for judging virus gene type |
| US5830853A (en) | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
| AU7551594A (en) | 1993-07-29 | 1995-02-28 | MURASHIGE, Kate H. | Method for recognition of the nucleotide sequence of a purified dna segment |
| GB9315847D0 (en) | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| US6376178B1 (en) | 1993-09-03 | 2002-04-23 | Duke University | Method of nucleic acid sequencing |
| WO1995006752A1 (en) | 1993-09-03 | 1995-03-09 | Duke University | A method of nucleic acid sequencing |
| US5502177A (en) | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| WO1995011996A1 (en) | 1993-10-27 | 1995-05-04 | Cornell Research Foundation, Inc. | Detection assay for listeria and erwinia microorganisms |
| US5504327A (en) | 1993-11-04 | 1996-04-02 | Hv Ops, Inc. (H-Nu) | Electrospray ionization source and method for mass spectrometric analysis |
| DE4338119A1 (en) | 1993-11-08 | 1995-05-11 | Bayer Ag | Specific gene probes and methods for the quantitative detection of methicillin-resistant staphylococci |
| NL9301957A (en) | 1993-11-11 | 1995-06-01 | U Gene Research Bv | Method for identifying microorganisms, and useful tools. |
| US5928905A (en) | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
| US5849492A (en) | 1994-02-28 | 1998-12-15 | Phylogenetix Laboratories, Inc. | Method for rapid identification of prokaryotic and eukaryotic organisms |
| US5608217A (en) | 1994-03-10 | 1997-03-04 | Bruker-Franzen Analytik Gmbh | Electrospraying method for mass spectrometric analysis |
| DE4444229C2 (en) | 1994-03-10 | 1996-07-25 | Bruker Franzen Analytik Gmbh | Methods and devices for electrospray ionization for storage mass spectrometers |
| US5976798A (en) | 1994-03-30 | 1999-11-02 | Mitokor | Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid |
| AU7242994A (en) | 1994-05-20 | 1995-12-18 | United States Of America, As Represented By The Secretary Of The Army, The | Model for testing immunogenicity of peptides |
| US5814442A (en) | 1994-06-10 | 1998-09-29 | Georgetown University | Internally controlled virion nucleic acid amplification reaction for quantitation of virion and virion nucleic acid |
| DE4421901A1 (en) | 1994-06-23 | 1996-01-04 | Bayer Ag | A rapid DNA test for the detection of quinolone-resistant Staphylococcus aureus pathogens in clinical specimens |
| GB9417211D0 (en) | 1994-08-25 | 1994-10-12 | Solicitor For The Affairs Of H | Nucleotide sequencing method |
| US6001564A (en) | 1994-09-12 | 1999-12-14 | Infectio Diagnostic, Inc. | Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| US20020055101A1 (en) | 1995-09-11 | 2002-05-09 | Michel G. Bergeron | Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| CA2118048C (en) * | 1994-09-30 | 2003-04-08 | James W. Schumm | Multiplex amplification of short tandem repeat loci |
| US5753489A (en) | 1994-11-10 | 1998-05-19 | Immuno Ag | Method for producing viruses and vaccines in serum-free culture |
| US5654141A (en) | 1994-11-18 | 1997-08-05 | Thomas Jefferson University | Amplification based detection of bacterial infection |
| KR100399813B1 (en) | 1994-12-14 | 2004-06-09 | 가부시키가이샤 니콘 | Exposure apparatus |
| US5763169A (en) | 1995-01-13 | 1998-06-09 | Chiron Diagnostics Corporation | Nucleic acid probes for the detection and identification of fungi |
| US6180339B1 (en) | 1995-01-13 | 2001-01-30 | Bayer Corporation | Nucleic acid probes for the detection and identification of fungi |
| US5707802A (en) | 1995-01-13 | 1998-01-13 | Ciba Corning Diagnostics Corp. | Nucleic acid probes for the detection and identification of fungi |
| US5702895A (en) | 1995-01-19 | 1997-12-30 | Wakunaga Seiyaku Kabushiki Kaisha | Method and kit for detecting methicillin-resistant Staphylococcus aureus |
| GB9504598D0 (en) | 1995-03-03 | 1995-04-26 | Imp Cancer Res Tech | Method of nucleic acid analysis |
| US6428955B1 (en) | 1995-03-17 | 2002-08-06 | Sequenom, Inc. | DNA diagnostics based on mass spectrometry |
| WO1996032504A2 (en) | 1995-04-11 | 1996-10-17 | Trustees Of Boston University | Solid phase sequencing of biopolymers |
| US5932220A (en) | 1995-05-08 | 1999-08-03 | Board Of Regents University Of Texas System | Diagnostic tests for a new spirochete, Borrelia lonestari sp. nov. |
| US5625184A (en) | 1995-05-19 | 1997-04-29 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
| US5830655A (en) | 1995-05-22 | 1998-11-03 | Sri International | Oligonucleotide sizing using cleavable primers |
| US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
| NZ308970A (en) | 1995-06-07 | 1999-10-28 | Commw Scient Ind Res Org | Optimized minizymes and miniribozymes and uses thereof |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US6218529B1 (en) | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
| US6146854A (en) | 1995-08-31 | 2000-11-14 | Sequenom, Inc. | Filtration processes, kits and devices for isolating plasmids |
| US5994066A (en) | 1995-09-11 | 1999-11-30 | Infectio Diagnostic, Inc. | Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| US5869242A (en) | 1995-09-18 | 1999-02-09 | Myriad Genetics, Inc. | Mass spectrometry to assess DNA sequence polymorphisms |
| US5727202A (en) | 1995-10-18 | 1998-03-10 | Palm Computing, Inc. | Method and apparatus for synchronizing information on two different computer systems |
| US5972693A (en) | 1995-10-24 | 1999-10-26 | Curagen Corporation | Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5871697A (en) | 1995-10-24 | 1999-02-16 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5716825A (en) | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
| EP0780470B1 (en) * | 1995-12-18 | 2001-06-06 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Beta-fructofuranosidase, its preparation and uses |
| US6312893B1 (en) | 1996-01-23 | 2001-11-06 | Qiagen Genomics, Inc. | Methods and compositions for determining the sequence of nucleic acid molecules |
| GB9602028D0 (en) | 1996-02-01 | 1996-04-03 | Amersham Int Plc | Nucleoside analogues |
| US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| AU2069597A (en) | 1996-03-04 | 1997-09-22 | Genetrace Systems, Inc. | Methods of screening nucleic acids using mass spectrometry |
| AU2217597A (en) | 1996-03-18 | 1997-10-22 | Sequenom, Inc. | Dna sequencing by mass spectrometry |
| JP4693944B2 (en) | 1996-03-20 | 2011-06-01 | ベーイーオー・メリュー | Nucleic acid isolation method |
| JP3365198B2 (en) | 1996-03-21 | 2003-01-08 | ミノルタ株式会社 | Image forming device |
| US5745751A (en) | 1996-04-12 | 1998-04-28 | Nelson; Robert W. | Civil site information system |
| US6214555B1 (en) | 1996-05-01 | 2001-04-10 | Visible Genetics Inc. | Method compositions and kit for detection |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| JP2000512497A (en) | 1996-06-10 | 2000-09-26 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション | Rapid and accurate identification of mutant DNA sequences by electrospray mass spectrometry |
| AU4042597A (en) | 1996-07-19 | 1998-02-10 | Hybridon, Inc. | Method for sequencing nucleic acids using matrix-assisted laser desorption ionization time-of-flight mass spectrometry |
| US6563025B1 (en) | 1996-07-26 | 2003-05-13 | Board Of Trustees Of The University Of Illinois | Nucleotide sequences encoding anthranilate synthase |
| US5831046A (en) * | 1996-08-05 | 1998-11-03 | Prolinx, Incorporated | Boronic acid-contaning nucleic acid monomers |
| DE19633436A1 (en) | 1996-08-20 | 1998-02-26 | Boehringer Mannheim Gmbh | Method for the detection of nucleic acids by determining the mass |
| US5965363A (en) | 1996-09-19 | 1999-10-12 | Genetrace Systems Inc. | Methods of preparing nucleic acids for mass spectrometric analysis |
| AU4591697A (en) | 1996-09-19 | 1998-04-14 | Genetrace Systems, Inc. | Methods of preparing nucleic acids for mass spectrometric analysis |
| US5777324A (en) | 1996-09-19 | 1998-07-07 | Sequenom, Inc. | Method and apparatus for maldi analysis |
| US6361940B1 (en) | 1996-09-24 | 2002-03-26 | Qiagen Genomics, Inc. | Compositions and methods for enhancing hybridization and priming specificity |
| US5864137A (en) | 1996-10-01 | 1999-01-26 | Genetrace Systems, Inc. | Mass spectrometer |
| US5885775A (en) | 1996-10-04 | 1999-03-23 | Perseptive Biosystems, Inc. | Methods for determining sequences information in polynucleotides using mass spectrometry |
| GB9620769D0 (en) | 1996-10-04 | 1996-11-20 | Brax Genomics Ltd | Nucleic acid sequencing |
| US6110710A (en) | 1996-10-15 | 2000-08-29 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Sequence modification of oligonucleotide primers to manipulate non-templated nucleotide addition |
| US6140053A (en) | 1996-11-06 | 2000-10-31 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| CA2268740C (en) | 1996-11-06 | 2010-07-20 | Sequenom, Inc. | High density immobilization of nucleic acids |
| US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
| US7285422B1 (en) | 1997-01-23 | 2007-10-23 | Sequenom, Inc. | Systems and methods for preparing and analyzing low volume analyte array elements |
| CA2270132A1 (en) | 1996-11-06 | 1998-05-14 | Sequenom, Inc. | Dna diagnostics based on mass spectrometry |
| US6024925A (en) * | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
| US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| US6060246A (en) | 1996-11-15 | 2000-05-09 | Avi Biopharma, Inc. | Reagent and method for isolation and detection of selected nucleic acid sequences |
| CA2273097A1 (en) * | 1996-11-28 | 1998-06-04 | New Japan Chemical Co., Ltd. | Sugar compounds, gelling agents, gelling agent compositions, processes for the preparation of them, and gel compositions |
| US5822824A (en) | 1996-12-03 | 1998-10-20 | Dion; William D. | Mountable washing device |
| CA2274587A1 (en) | 1996-12-10 | 1998-06-18 | Genetrace Systems Inc. | Releasable nonvolatile mass-label molecules |
| US5981190A (en) | 1997-01-08 | 1999-11-09 | Ontogeny, Inc. | Analysis of gene expression, methods and reagents therefor |
| JP3884087B2 (en) | 1997-01-15 | 2007-02-21 | イクスツィリオン ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | Mass label binding hybridization probe |
| US6046005A (en) | 1997-01-15 | 2000-04-04 | Incyte Pharmaceuticals, Inc. | Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group |
| US5876936A (en) | 1997-01-15 | 1999-03-02 | Incyte Pharmaceuticals, Inc. | Nucleic acid sequencing with solid phase capturable terminators |
| US6194114B1 (en) | 1997-01-17 | 2001-02-27 | Mitsui Chemicals, Inc. | Heat-fixable developer for electrophotography |
| WO1998035057A1 (en) | 1997-02-06 | 1998-08-13 | The National University Of Singapore | Diagnosis of plasmodium infection by analysis of extrachromosomal genetic material |
| US6727061B2 (en) | 1997-02-20 | 2004-04-27 | Cabtec, Inc. | Methods for identifying species or Shigella and E. coli using operon sequence analysis |
| US5828062A (en) | 1997-03-03 | 1998-10-27 | Waters Investments Limited | Ionization electrospray apparatus for mass spectrometry |
| US6553317B1 (en) | 1997-03-05 | 2003-04-22 | Incyte Pharmaceuticals, Inc. | Relational database and system for storing information relating to biomolecular sequences and reagents |
| JP3672158B2 (en) * | 1997-03-10 | 2005-07-13 | 富士電機システムズ株式会社 | Turbidity measuring method and apparatus |
| DE19710166C1 (en) | 1997-03-12 | 1998-12-10 | Bruker Franzen Analytik Gmbh | Two-step method of DNA amplification for MALDI-TOF measurements |
| AU6553498A (en) | 1997-03-14 | 1998-09-29 | Hybridon, Inc. | Method for sequencing of modified nucleic acids using electrospray ionization-fourier transform mass spectrometry |
| US5849497A (en) | 1997-04-03 | 1998-12-15 | The Research Foundation Of State University Of New York | Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker |
| US6018713A (en) | 1997-04-09 | 2000-01-25 | Coli; Robert D. | Integrated system and method for ordering and cumulative results reporting of medical tests |
| DE19717085C2 (en) | 1997-04-23 | 1999-06-17 | Bruker Daltonik Gmbh | Processes and devices for extremely fast DNA multiplication using polymerase chain reactions (PCR) |
| US20010039263A1 (en) | 1997-05-02 | 2001-11-08 | Max-Delbruck-Centrum Fur Molekulare Medizin | Chimeric oligonucleotides and the use thereof |
| US6054278A (en) | 1997-05-05 | 2000-04-25 | The Perkin-Elmer Corporation | Ribosomal RNA gene polymorphism based microorganism identification |
| US6994960B1 (en) | 1997-05-28 | 2006-02-07 | The Walter And Eliza Hall Institute Of Medical Research | Nucleic acid diagnostics based on mass spectrometry or mass separation and base specific cleavage |
| US6159681A (en) | 1997-05-28 | 2000-12-12 | Syntrix Biochip, Inc. | Light-mediated method and apparatus for the regional analysis of biologic material |
| CA2302036C (en) | 1997-05-30 | 2003-09-02 | Genetrace Systems, Inc. | Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry |
| US6061686A (en) | 1997-06-26 | 2000-05-09 | Digital Equipment Corporation | Updating a copy of a remote document stored in a local computer system |
| CN1270598A (en) | 1997-07-22 | 2000-10-18 | 拉普吉恩公司 | Methods and compounds for analyzing nucleic acids by mass spectrometry |
| DE19732086C2 (en) | 1997-07-25 | 2002-11-21 | Univ Leipzig | Method for the quantitative determination of eubacteria |
| US6207370B1 (en) | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
| GB9719044D0 (en) | 1997-09-08 | 1997-11-12 | Inst Of Ophthalmology | Assay |
| WO1999014375A2 (en) | 1997-09-19 | 1999-03-25 | Genetrace Systems, Inc. | Dna typing by mass spectrometry with polymorphic dna repeat markers |
| US6063031A (en) | 1997-10-14 | 2000-05-16 | Assurance Medical, Inc. | Diagnosis and treatment of tissue with instruments |
| US6111096A (en) | 1997-10-31 | 2000-08-29 | Bbi Bioseq, Inc. | Nucleic acid isolation and purification |
| JP3423597B2 (en) | 1997-11-05 | 2003-07-07 | 三井農林株式会社 | Bacterial identification method |
| US6028183A (en) | 1997-11-07 | 2000-02-22 | Gilead Sciences, Inc. | Pyrimidine derivatives and oligonucleotides containing same |
| US6007992A (en) | 1997-11-10 | 1999-12-28 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| JP2001526381A (en) | 1997-12-05 | 2001-12-18 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | Nucleic acid identification method by matrix-assisted laser desorption / ionization mass spectrometry |
| US6914137B2 (en) | 1997-12-06 | 2005-07-05 | Dna Research Innovations Limited | Isolation of nucleic acids |
| US6268131B1 (en) | 1997-12-15 | 2001-07-31 | Sequenom, Inc. | Mass spectrometric methods for sequencing nucleic acids |
| US20030096232A1 (en) | 1997-12-19 | 2003-05-22 | Kris Richard M. | High throughput assay system |
| US6458533B1 (en) | 1997-12-19 | 2002-10-01 | High Throughput Genomics, Inc. | High throughput assay system for monitoring ESTs |
| GB9815166D0 (en) | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds for mass spectrometry |
| DE19802905C2 (en) | 1998-01-27 | 2001-11-08 | Bruker Daltonik Gmbh | Process for the preferred production of only one strand of selected genetic material for mass spectrometric measurements |
| DE19808584C1 (en) * | 1998-02-28 | 1999-08-26 | Bruker Daltonik Gmbh | Evaluation method for raw data of mass spectra of analyte ions with ion currents measured at recurring intervals and stored at sequential addresses in memory, with respect to the occurrence or non-occurence of ions with known masses |
| US6428956B1 (en) | 1998-03-02 | 2002-08-06 | Isis Pharmaceuticals, Inc. | Mass spectrometric methods for biomolecular screening |
| AU754999B2 (en) | 1998-03-10 | 2002-11-28 | Large Scale Proteomics Corporation | Detection and characterization of microorganisms |
| US6270973B1 (en) | 1998-03-13 | 2001-08-07 | Promega Corporation | Multiplex method for nucleic acid detection |
| US6235480B1 (en) | 1998-03-13 | 2001-05-22 | Promega Corporation | Detection of nucleic acid hybrids |
| US6268146B1 (en) | 1998-03-13 | 2001-07-31 | Promega Corporation | Analytical methods and materials for nucleic acid detection |
| US6277578B1 (en) | 1998-03-13 | 2001-08-21 | Promega Corporation | Deploymerization method for nucleic acid detection of an amplified nucleic acid target |
| US6391551B1 (en) | 1998-03-13 | 2002-05-21 | Promega Corporation | Detection of nucleic acid hybrids |
| US6312902B1 (en) | 1998-03-13 | 2001-11-06 | Promega Corporation | Nucleic acid detection |
| US6270974B1 (en) | 1998-03-13 | 2001-08-07 | Promega Corporation | Exogenous nucleic acid detection |
| US6261769B1 (en) | 1998-03-31 | 2001-07-17 | The United States Of America As Represented By The Secretary Of Agriculture | Intergenic spacer target sequence for detecting and distinguishing Chlamydial species or strains |
| US20030228597A1 (en) | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| US7321828B2 (en) | 1998-04-13 | 2008-01-22 | Isis Pharmaceuticals, Inc. | System of components for preparing oligonucleotides |
| US6223186B1 (en) | 1998-05-04 | 2001-04-24 | Incyte Pharmaceuticals, Inc. | System and method for a precompiled database for biomolecular sequence information |
| US6723564B2 (en) | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
| US6221587B1 (en) | 1998-05-12 | 2001-04-24 | Isis Pharmceuticals, Inc. | Identification of molecular interaction sites in RNA for novel drug discovery |
| DE19822108A1 (en) | 1998-05-12 | 2000-02-03 | Schering Ag | Method for the detection of microorganisms in products, in particular in medicines and cosmetics |
| US6468743B1 (en) | 1998-05-18 | 2002-10-22 | Conagra Grocery Products Company | PCR techniques for detecting microbial contaminants in foodstuffs |
| DE19922161A1 (en) | 1998-05-18 | 1999-12-09 | Fraunhofer Ges Forschung | Anti-adhesion coating for e.g. soldering/welding tools and electric contacts |
| US6104028A (en) | 1998-05-29 | 2000-08-15 | Genetrace Systems Inc. | Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry |
| DE19824280B4 (en) | 1998-05-29 | 2004-08-19 | Bruker Daltonik Gmbh | Mutation analysis using mass spectrometry |
| US6104027A (en) * | 1998-06-05 | 2000-08-15 | Hewlett-Packard Company | Deconvolution of multiply charged ions |
| US6107649A (en) | 1998-06-10 | 2000-08-22 | Rutgers, The State University | Field-controlled high-power semiconductor devices |
| GB2339905A (en) | 1998-06-24 | 2000-02-09 | Bruker Daltonik Gmbh | Use of mass-specrometry for detection of mutations |
| CA2333253C (en) | 1998-07-02 | 2010-09-07 | Gen-Probe Incorporated | Molecular torches |
| US6074831A (en) | 1998-07-09 | 2000-06-13 | Agilent Technologies, Inc. | Partitioning of polymorphic DNAs |
| US6218118B1 (en) | 1998-07-09 | 2001-04-17 | Agilent Technologies, Inc. | Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry |
| US6432651B1 (en) | 1998-07-10 | 2002-08-13 | Cetek Corporation | Method to detect and analyze tight-binding ligands in complex biological samples using capillary electrophoresis and mass spectrometry |
| US6605433B1 (en) | 1998-08-20 | 2003-08-12 | The Johns Hopkins University | Mitochondrial dosimeter |
| US6146144A (en) | 1998-09-29 | 2000-11-14 | Fowler; Ernest R. | Rug hooking kit and method for handicapped |
| US6610492B1 (en) | 1998-10-01 | 2003-08-26 | Variagenics, Inc. | Base-modified nucleotides and cleavage of polynucleotides incorporating them |
| AU6412799A (en) | 1998-10-05 | 2000-04-26 | Mosaic Technologies | Reverse displacement assay for detection of nucleic acid sequences |
| US6221602B1 (en) * | 1998-11-10 | 2001-04-24 | Bio-Pixels Ltd. | Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination |
| DE19852167C2 (en) | 1998-11-12 | 2000-12-14 | Bruker Saxonia Analytik Gmbh | Simple SNP analysis using mass spectrometry |
| CA2351671A1 (en) | 1998-11-24 | 2000-06-08 | Regents Of The University Of Minnesota | Transgenic circulating endothelial cells |
| US6994962B1 (en) | 1998-12-09 | 2006-02-07 | Massachusetts Institute Of Technology | Methods of identifying point mutations in a genome |
| DE19859723A1 (en) | 1998-12-23 | 2000-06-29 | Henkel Kgaa | Preparations for coloring keratinous fibers |
| US6503718B2 (en) | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
| US6638714B1 (en) | 1999-02-03 | 2003-10-28 | Ortho-Clinical Diagnostics, Inc. | Oligonucleotide primers for efficient detection of hepatitis C virus (HCV) and methods of use thereof |
| US6153389A (en) | 1999-02-22 | 2000-11-28 | Haarer; Brian K. | DNA additives as a mechanism for unambiguously marking biological samples |
| EP1035219A1 (en) | 1999-02-25 | 2000-09-13 | Universiteit Gent | Gastric helicobacter 16 S rDNA sequences from cattle and pigs and their use for detection and typing of Helicobacter strains |
| US6436640B1 (en) | 1999-03-18 | 2002-08-20 | Exiqon A/S | Use of LNA in mass spectrometry |
| US6613509B1 (en) | 1999-03-22 | 2003-09-02 | Regents Of The University Of California | Determination of base (nucleotide) composition in DNA oligomers by mass spectrometry |
| US20020009394A1 (en) * | 1999-04-02 | 2002-01-24 | Hubert Koster | Automated process line |
| WO2000063362A1 (en) | 1999-04-21 | 2000-10-26 | Annovis, Inc. | Magnetic dna extraction kit for plants |
| US6649351B2 (en) | 1999-04-30 | 2003-11-18 | Aclara Biosciences, Inc. | Methods for detecting a plurality of analytes by mass spectrometry |
| US6140067A (en) | 1999-04-30 | 2000-10-31 | Mitokor | Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus |
| EP1177318B1 (en) | 1999-05-03 | 2008-02-13 | Gen-Probe Incorporated | Polynucleotide matrix-based method of identifying microorganisms |
| US20030083483A1 (en) * | 1999-05-12 | 2003-05-01 | Ecker David J. | Molecular interaction sites of vimentin RNA and methods of modulating the same |
| US6969763B1 (en) * | 1999-05-12 | 2005-11-29 | Isis Pharmaceuticals, Inc. | Molecular interaction sites of interleukin-2 RNA and methods of modulating the same |
| US20020086289A1 (en) | 1999-06-15 | 2002-07-04 | Don Straus | Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms |
| NZ516381A (en) | 1999-06-30 | 2004-03-26 | Corixa Corp | Lung tumor proteins in the therapy and diagnosis of lung cancer |
| EP1198597A1 (en) | 1999-07-22 | 2002-04-24 | Artus Gesellschaft Für Molekularbiologische Diagnostik und Entwicklung MbH. | Method for the species-specific detection of organisms |
| US6723505B1 (en) | 1999-08-13 | 2004-04-20 | Nye Colifast As | Method for identification of the indicators of contamination in liquid samples |
| US6266144B1 (en) | 1999-08-26 | 2001-07-24 | Taiwan Semiconductor Manufacturing Company | Stepper and scanner new exposure sequence with intra-field correction |
| DE19943374A1 (en) | 1999-09-10 | 2001-03-29 | Max Planck Gesellschaft | Method for binding nucleic acids to a solid phase |
| US7005274B1 (en) | 1999-09-15 | 2006-02-28 | Migenix Corp. | Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass |
| WO2001023608A2 (en) | 1999-09-27 | 2001-04-05 | Merck Sharp & Dohme De Espana, S.A.E. | Hybridization probes which specifically detect strains of the genera microbispora, microtetraspora, nonomuria and planobispora |
| EP1246935B1 (en) | 1999-09-28 | 2013-08-14 | Geneohm Sciences Canada Inc. | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
| US6296188B1 (en) | 1999-10-01 | 2001-10-02 | Perfect Plastic Printing Corporation | Transparent/translucent financial transaction card including an infrared light filter |
| US6787302B2 (en) | 1999-10-25 | 2004-09-07 | Genprime, Inc. | Method and apparatus for prokaryotic and eukaryotic cell quantitation |
| CA2388528A1 (en) | 1999-11-04 | 2001-05-10 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
| US6856914B1 (en) | 1999-11-19 | 2005-02-15 | The University Of British Columbia | Method, apparatus, media and signals for identifying associated cell signaling proteins |
| WO2001040497A2 (en) | 1999-11-29 | 2001-06-07 | Aventis Pharma S.A. | Method for obtaining nucleic acids from an environment sample |
| AU2430601A (en) * | 1999-12-13 | 2001-06-18 | Semequip, Inc. | Ion implantation ion source, system and method |
| US6608190B1 (en) | 1999-12-16 | 2003-08-19 | E. I. Du Pont De Nemours And Company | Nucleic acid fragments for the identification of bacteria in industrial wastewater bioreactors |
| US6936414B2 (en) | 1999-12-22 | 2005-08-30 | Abbott Laboratories | Nucleic acid isolation method and kit |
| ATE317024T1 (en) | 1999-12-29 | 2006-02-15 | Keygene Nv | METHOD FOR GENERATING OLIGONUCLEOTIDES, IN PARTICULAR FOR DETECTING AMPLIFIED RESTRICTION FRAGMENTS OBTAINED BY AFLP |
| SE0000061D0 (en) | 2000-01-10 | 2000-01-10 | Bjoern Herrmann | A method for detection of pathogenic organisms |
| AU2001232485A1 (en) | 2000-01-13 | 2001-07-24 | Amsterdam Support Diagnostics B.V. | A universal nucleic acid amplification system for nucleic acids in a sample |
| CA2298181C (en) | 2000-02-02 | 2006-09-19 | Dayan Burke Goodnough | Non-targeted complex sample analysis |
| US20020009727A1 (en) | 2000-02-02 | 2002-01-24 | Schultz Gary A. | Detection of single nucleotide polymorphisms |
| US6453244B1 (en) | 2000-02-10 | 2002-09-17 | Stanford University | Detection of polymorphisms by denaturing high-performance liquid chromatography |
| EP1266338A2 (en) | 2000-02-14 | 2002-12-18 | First Opinion Corporation | Automated diagnostic system and method |
| US6393367B1 (en) | 2000-02-19 | 2002-05-21 | Proteometrics, Llc | Method for evaluating the quality of comparisons between experimental and theoretical mass data |
| DE10015797B4 (en) | 2000-03-26 | 2006-02-02 | Bruker Daltonik Gmbh | Multiplex analysis of DNA mixtures using photolytically readable DNA chips |
| DE10015262A1 (en) | 2000-03-28 | 2001-10-04 | Basf Ag | Paper coating composition useful for off set printing, contains a binding agent prepared by radical polymerization of ethylenically unsaturated compounds |
| NZ521626A (en) | 2000-03-29 | 2005-09-30 | Cambia | Methods for genotyping by hybridization analysis |
| DK2278030T3 (en) | 2000-04-10 | 2017-07-24 | Taxon Biosciences Inc | METHODS OF RESEARCH AND GENETIC ANALYSIS OF POPULATIONS |
| FR2807767B1 (en) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | MONOCLONAL ANTIBODIES ANTI-D |
| US6475736B1 (en) | 2000-05-23 | 2002-11-05 | Variagenics, Inc. | Methods for genetic analysis of DNA using biased amplification of polymorphic sites |
| US6716634B1 (en) | 2000-05-31 | 2004-04-06 | Agilent Technologies, Inc. | Increasing ionization efficiency in mass spectrometry |
| US6507837B1 (en) | 2000-06-08 | 2003-01-14 | Hyperphrase Technologies, Llc | Tiered and content based database searching |
| US20020177552A1 (en) | 2000-06-09 | 2002-11-28 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of colon cancer |
| ATE423221T1 (en) | 2000-06-13 | 2009-03-15 | Univ Boston | USE OF MASS-MATCHED NUCLEOTIDES IN THE ANALYSIS OF OLIGONUCLEOTIDE MIXTURES AND IN HIGH-MULTIPLEX NUCLEIC ACID SEQUENCING |
| EP1170379A1 (en) | 2000-06-30 | 2002-01-09 | Centre National de Genotypage | Sample generation for genotyping by mass spectrometry |
| FR2811321A1 (en) | 2000-07-04 | 2002-01-11 | Bio Merieux | New oligonucleotide primers, useful for identifying bacteria, particularly in cases of septicemia, provide amplification of bacterial 16S ribosomal nucleic acid |
| US6504021B2 (en) | 2000-07-05 | 2003-01-07 | Edge Biosystems, Inc. | Ion exchange method for DNA purification |
| AU2001272629A1 (en) | 2000-07-06 | 2002-01-14 | Bio Merieux | Method for controlling the microbiological quality of an aqueous medium and kit therefor |
| US6783939B2 (en) | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
| US6811977B2 (en) | 2000-07-27 | 2004-11-02 | California Institute Of Technology | Rapid, quantitative method for the mass spectrometric analysis of nucleic acids for gene expression and genotyping |
| AUPQ909000A0 (en) | 2000-07-28 | 2000-08-24 | University Of Sydney, The | A method of detecting microorganisms |
| GB0021286D0 (en) | 2000-08-30 | 2000-10-18 | Gemini Genomics Ab | Identification of drug metabolic capacity |
| US20030190635A1 (en) | 2002-02-20 | 2003-10-09 | Mcswiggen James A. | RNA interference mediated treatment of Alzheimer's disease using short interfering RNA |
| US20040005555A1 (en) | 2000-08-31 | 2004-01-08 | Rothman Richard E. | Molecular diagnosis of bactermia |
| US6813615B1 (en) | 2000-09-06 | 2004-11-02 | Cellomics, Inc. | Method and system for interpreting and validating experimental data with automated reasoning |
| US7349808B1 (en) | 2000-09-06 | 2008-03-25 | Egenomics, Inc. | System and method for tracking and controlling infections |
| US20020120408A1 (en) | 2000-09-06 | 2002-08-29 | Kreiswirth Barry N. | System and method for tracking and controlling infections |
| WO2002021108A2 (en) | 2000-09-08 | 2002-03-14 | Large Scale Proteomics Corporation | Method for detecting molecules or chemical reactions by determining variation of conductance |
| SE0003286D0 (en) | 2000-09-15 | 2000-09-15 | Ulf Gyllensten | Method and kit for human identification |
| EP1358319B1 (en) | 2000-09-25 | 2009-06-17 | Polymun Scientific Immunbiologische Forschung GmbH | Live influenza vaccine and method of manufacture |
| WO2002028901A2 (en) | 2000-10-05 | 2002-04-11 | Millennium Pharmaceuticals, Inc. | Seven-transmembrane (7tm) receptors and uses thereof |
| US6996472B2 (en) | 2000-10-10 | 2006-02-07 | The United States Of America As Represented By The Department Of Health And Human Services | Drift compensation method for fingerprint spectra |
| WO2002031747A1 (en) | 2000-10-13 | 2002-04-18 | Irm Llc | High throughput processing system and method of using |
| US6858412B2 (en) | 2000-10-24 | 2005-02-22 | The Board Of Trustees Of The Leland Stanford Junior University | Direct multiplex characterization of genomic DNA |
| US6906316B2 (en) | 2000-10-27 | 2005-06-14 | Fuji Electric Co., Ltd. | Semiconductor device module |
| US6682889B1 (en) | 2000-11-08 | 2004-01-27 | Becton, Dickinson And Company | Amplification and detection of organisms of the Chlamydiaceae family |
| AU2002222614A1 (en) | 2000-12-12 | 2002-07-01 | Chugai Seiyaku Kabushiki Kaisha | Method of detecting polymorphism in dna by using mass spectroscopy |
| US6800289B2 (en) | 2000-12-21 | 2004-10-05 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence | Strain of the western equine encephalitis virus |
| US6586584B2 (en) | 2001-01-29 | 2003-07-01 | Becton, Dickinson And Company | Sequences and methods for detection of Hepatitis C virus |
| US6707038B2 (en) * | 2001-02-14 | 2004-03-16 | Picoliter Inc. | Method and system using acoustic ejection for selective fluid deposition on a nonuniform sample surface |
| DE10108453B4 (en) | 2001-02-22 | 2005-10-20 | Bruker Daltonik Gmbh | Mass spectrometric mutation analysis with photolytically cleavable primers |
| KR20040055733A (en) | 2001-02-28 | 2004-06-26 | 콘드로진 인코포레이티드 | Compositions and methods relating to osteoarthritis |
| WO2002070728A2 (en) | 2001-03-01 | 2002-09-12 | The Johns Hopkins University | Quantitative assay for the simultaneous detection and speciation of bacterial infections |
| JP2002260577A (en) * | 2001-03-01 | 2002-09-13 | Jeol Ltd | Method and device for collecting data for time-of-flight mass spectroscope |
| US7666588B2 (en) | 2001-03-02 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy |
| US20040121310A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in forensic studies |
| WO2004060278A2 (en) | 2002-12-06 | 2004-07-22 | Isis Pharmaceuticals, Inc. | Methods for rapid identification of pathogens in humans and animals |
| US20040121314A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in containers |
| US7226739B2 (en) | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
| US20040121313A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in organs for transplantation |
| US20030027135A1 (en) | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
| US7718354B2 (en) | 2001-03-02 | 2010-05-18 | Ibis Biosciences, Inc. | Methods for rapid identification of pathogens in humans and animals |
| US20040038206A1 (en) | 2001-03-14 | 2004-02-26 | Jia Zhang | Method for high throughput assay of genetic analysis |
| US20030104410A1 (en) | 2001-03-16 | 2003-06-05 | Affymetrix, Inc. | Human microarray |
| EP2332896A3 (en) | 2001-03-19 | 2012-09-26 | President and Fellows of Harvard College | Evolving new molecular function |
| AU2001258719B2 (en) | 2001-03-28 | 2007-09-06 | Council Of Scientific And Industrial Research | Universal primers for wildlife identification |
| US7630836B2 (en) | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| CA2348042A1 (en) | 2001-06-04 | 2002-12-04 | Ann Huletsky | Sequences for detection and identification of methicillin-resistant staphylococcus aureus |
| US20020187477A1 (en) | 2001-06-06 | 2002-12-12 | Hong Xue | Method for detecting single nucleotide polymorphisms (SNPs) and point mutations |
| CN1630718A (en) | 2001-06-06 | 2005-06-22 | Dsmip资产公司 | Improved isoprenoid production |
| GB0113907D0 (en) | 2001-06-07 | 2001-08-01 | Univ London | Virus detection using degenerate PCR primers |
| GB0113908D0 (en) | 2001-06-07 | 2001-08-01 | Univ London | Designing degenerate PCR primers |
| US20020187490A1 (en) | 2001-06-07 | 2002-12-12 | Michigan State University | Microbial identification chip based on DNA-DNA hybridization |
| US7217510B2 (en) | 2001-06-26 | 2007-05-15 | Isis Pharmaceuticals, Inc. | Methods for providing bacterial bioagent characterizing information |
| US8073627B2 (en) | 2001-06-26 | 2011-12-06 | Ibis Biosciences, Inc. | System for indentification of pathogens |
| DE10132147B4 (en) | 2001-07-03 | 2004-04-15 | Universität Leipzig | Method for the rapid quantitative determination of Eu bacteria |
| GB0117054D0 (en) | 2001-07-12 | 2001-09-05 | Plant Bioscience Ltd | Methods and means for modification of plant characteristics |
| US7494771B2 (en) | 2001-07-19 | 2009-02-24 | Geneohm Sciences Canada, Inc. | Universal method and composition for the rapid lysis of cells for the release of nucleic acids and their detection |
| US20040191769A1 (en) | 2001-07-24 | 2004-09-30 | Transgenomic, Inc. | Methods, compositions, and kits for mutation detection in mitochondrial DNA |
| AU2002325197A1 (en) | 2001-07-30 | 2003-02-17 | Den Kgl. Veterinaer- Og Landbohojskole | Bacterial strains belonging to lactobacillus species and their use in food and feed industry |
| US7115385B2 (en) | 2001-08-02 | 2006-10-03 | North Carolina State University | Media and methods for cultivation of microorganisms |
| AT411174B (en) | 2001-08-09 | 2003-10-27 | Lambda Labor Fuer Molekularbio | METHOD AND CHIP FOR ANALYZING NUCLEIC ACIDS |
| US20030039976A1 (en) | 2001-08-14 | 2003-02-27 | Haff Lawrence A. | Methods for base counting |
| WO2003016546A1 (en) | 2001-08-21 | 2003-02-27 | Flinders Technologies Pty Ltd. | Method and device for simultaneously molecularly cloning and polylocus profiling of genomes or genome mixtures |
| US7105296B2 (en) | 2001-08-29 | 2006-09-12 | E. I. Du Pont De Nemours And Company | Genes encoding Baeyer-Villiger monooxygenases |
| US7049286B2 (en) | 2001-08-30 | 2006-05-23 | Diatos, S.A. | Insulin conjugates and methods of use thereof |
| WO2003020739A2 (en) | 2001-09-04 | 2003-03-13 | Exiqon A/S | Novel lna compositions and uses thereof |
| JP3830366B2 (en) * | 2001-09-12 | 2006-10-04 | 日本電子株式会社 | Data collection method and apparatus for time-of-flight mass spectrometer |
| US20040101809A1 (en) | 2001-09-21 | 2004-05-27 | Weiss Ervin I | Device, method and materials for mobilizing substances into dentinal tubules in root canal treatment |
| DE10150121B4 (en) | 2001-10-11 | 2005-12-01 | Bernhard-Nocht-Institut für Tropenmedizin | Real-time detection of DNA amplification products |
| US6977148B2 (en) | 2001-10-15 | 2005-12-20 | Qiagen Gmbh | Multiple displacement amplification |
| US7297485B2 (en) | 2001-10-15 | 2007-11-20 | Qiagen Gmbh | Method for nucleic acid amplification that results in low amplification bias |
| US6835927B2 (en) * | 2001-10-15 | 2004-12-28 | Surromed, Inc. | Mass spectrometric quantification of chemical mixture components |
| DE10152821B4 (en) * | 2001-10-25 | 2006-11-16 | Bruker Daltonik Gmbh | Mass spectra without electronic noise |
| US20040029129A1 (en) | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| EP1308506A1 (en) | 2001-11-06 | 2003-05-07 | Eidgenössische Technische Hochschule Zürich | Mixtures of Propionibacterium jensenii and Lactobacillus sp. with antimicrobial activities for use as a natural preservation system |
| WO2003041116A1 (en) * | 2001-11-07 | 2003-05-15 | Hitachi High-Technologies Corporation | Mass spectrometry and ion trap mass spectrometer |
| CA3066428C (en) | 2001-11-13 | 2022-05-24 | The Trustees Of The University Of Pennsylvania | A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby |
| CA2477433C (en) | 2001-11-15 | 2010-07-06 | Whatman, Inc. | Methods and materials for detecting genetic material |
| US20040023209A1 (en) | 2001-11-28 | 2004-02-05 | Jon Jonasson | Method for identifying microorganisms based on sequencing gene fragments |
| JP3692067B2 (en) | 2001-11-30 | 2005-09-07 | 株式会社東芝 | Polishing slurry for copper CMP and method of manufacturing semiconductor device using the same |
| US20030148284A1 (en) | 2001-12-17 | 2003-08-07 | Vision Todd J. | Solid phase detection of nucleic acid molecules |
| TW509116U (en) | 2001-12-18 | 2002-11-01 | Ind Tech Res Inst | Device for clipping and tightening spindle of honing and milling machine |
| US20030175709A1 (en) | 2001-12-20 | 2003-09-18 | Murphy George L. | Method and system for depleting rRNA populations |
| US7468185B2 (en) | 2001-12-21 | 2008-12-23 | Pfizer Inc. | Vaccine for periodontal disease |
| AU2002358353A1 (en) | 2001-12-28 | 2003-07-30 | Keygene N.V. | Discrimination and detection of target nucleotide sequences using mass spectrometry |
| EP1333101B1 (en) | 2002-02-01 | 2007-03-28 | Bruker Daltonik GmbH | Mutation analysis by PCR and Mass spectrometry |
| JP3840417B2 (en) * | 2002-02-20 | 2006-11-01 | 株式会社日立ハイテクノロジーズ | Mass spectrometer |
| CN1202204C (en) | 2002-02-27 | 2005-05-18 | 财团法人工业技术研究院 | Organic electroluminescent light-emitting compound and module and device with it |
| KR100600988B1 (en) | 2002-03-13 | 2006-07-13 | 주식회사 엘지생명과학 | Method for enhancing immune responses by codelivering influenza NP DNA in DNA immunization |
| US7024370B2 (en) | 2002-03-26 | 2006-04-04 | P) Cis, Inc. | Methods and apparatus for early detection of health-related events in a population |
| US6897027B2 (en) | 2002-03-27 | 2005-05-24 | Decode Genetics Ehf. | Method for desalting nucleic acids |
| AU2003269809A1 (en) | 2002-04-01 | 2003-12-12 | Isis Pharmaceuticals, Inc. | Method for rapid detection and identification of viral bioagents |
| WO2003087993A2 (en) | 2002-04-09 | 2003-10-23 | Beattie Kenneth L | Oligonucleotide probes for genosensor chips |
| JP2004000200A (en) | 2002-04-19 | 2004-01-08 | Menicon Co Ltd | Method for detecting microorganism |
| FR2838740A1 (en) | 2002-04-22 | 2003-10-24 | Centre Nat Rech Scient | Detecting primate T cell lymphoma/leukemia viruses, useful e.g. for diagnosis and drug screening, using degenerate oligonucleotides based on conserved regions of envelope protein |
| GB0209812D0 (en) | 2002-04-30 | 2002-06-05 | Renovo Ltd | Genetic testing |
| US6906319B2 (en) * | 2002-05-17 | 2005-06-14 | Micromass Uk Limited | Mass spectrometer |
| DE10222632B4 (en) | 2002-05-17 | 2006-03-09 | Con Cipio Gmbh | Microsatellite markers for genetic analysis and for the differentiation of roses |
| EP1365031A1 (en) | 2002-05-21 | 2003-11-26 | MTM Laboratories AG | Method for detection of somatic mutations using mass spectometry |
| US20030220844A1 (en) | 2002-05-24 | 2003-11-27 | Marnellos Georgios E. | Method and system for purchasing genetic data |
| US20040014957A1 (en) | 2002-05-24 | 2004-01-22 | Anne Eldrup | Oligonucleotides having modified nucleoside units |
| EP1511847A1 (en) | 2002-05-29 | 2005-03-09 | Aresa Biodetection Aps | Reporter system for plants |
| GB0212666D0 (en) | 2002-05-31 | 2002-07-10 | Secr Defence | Immunogenic sequences |
| WO2003104410A2 (en) | 2002-06-07 | 2003-12-18 | Incyte Corporation | Enzymes |
| AU2003276494A1 (en) | 2002-06-13 | 2004-01-23 | Regulome Corporation | Functional sites |
| WO2004003511A2 (en) | 2002-07-01 | 2004-01-08 | Wayne State University | Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance |
| WO2004009849A1 (en) | 2002-07-19 | 2004-01-29 | Isis Pharmaceuticals, Inc. | Methods for mass spectrometry analysis utilizing an integrated microfluidics sample platform |
| US6916483B2 (en) | 2002-07-22 | 2005-07-12 | Biodynamics, Llc | Bioabsorbable plugs containing drugs |
| GB0217434D0 (en) | 2002-07-27 | 2002-09-04 | Royal Vetinary College | Biological material |
| US20040022764A1 (en) | 2002-07-31 | 2004-02-05 | Hanan Polansky | Inhibition of microcompetition with a foreign polynucleotide as treatment of chronic disease |
| US7172868B2 (en) | 2002-08-01 | 2007-02-06 | The Regents Of The University Of California | Nucleotide sequences specific to Francisella tularensis and methods for the detection of Francisella tularensis |
| JP4114717B2 (en) * | 2002-08-09 | 2008-07-09 | 浜松ホトニクス株式会社 | CT equipment |
| US6939387B2 (en) | 2002-08-19 | 2005-09-06 | Calcuim Silicate Corporation, Inc. | Soil enhancers |
| US20040038385A1 (en) | 2002-08-26 | 2004-02-26 | Langlois Richard G. | System for autonomous monitoring of bioagents |
| JP4683922B2 (en) * | 2002-09-06 | 2011-05-18 | トラスティーズ オブ ボストン ユニバーシティ | Gene expression quantification method |
| US6838665B2 (en) * | 2002-09-26 | 2005-01-04 | Hitachi High-Technologies Corporation | Ion trap type mass spectrometer |
| CA2410795A1 (en) | 2002-11-01 | 2004-05-01 | University Of Ottawa | A method for the amplification of multiple genetic targets |
| US20060257871A1 (en) | 2002-11-12 | 2006-11-16 | Franck Chaubron | One step real-time rt pcr kits for the universal detection of organisms in industrial products |
| US7250496B2 (en) | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| ATE459727T1 (en) | 2002-11-15 | 2010-03-15 | Gen Probe Inc | TEST AND COMPOSITIONS FOR DETECTING BACILLUS ANTHRACIS NUCLEIC ACID |
| US6680476B1 (en) * | 2002-11-22 | 2004-01-20 | Agilent Technologies, Inc. | Summed time-of-flight mass spectrometry utilizing thresholding to reduce noise |
| JP2004201679A (en) | 2002-12-10 | 2004-07-22 | Kao Corp | Primer for detecting fusobacterium nucleatum by pcr process and method for detecting the same |
| US20040117354A1 (en) | 2002-12-16 | 2004-06-17 | Azzaro Steven Hector | Process for tagging and measuring quality |
| US20040122598A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in food products and cosmetics thereby |
| US20040121329A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in blood, bodily fluids, and bodily tissues thereby |
| US20040121340A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent associated with host versus graft and graft versus host rejections thereby |
| US20040121312A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of the absence of bioagents |
| US20040121315A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in containers thereby |
| US20040122857A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in forensic studies thereby |
| US9487823B2 (en) | 2002-12-20 | 2016-11-08 | Qiagen Gmbh | Nucleic acid amplification |
| JP2004201641A (en) | 2002-12-26 | 2004-07-22 | Mitsubishi Kagaku Bio-Clinical Laboratories Inc | Detection of eumycetes |
| US20040170981A1 (en) | 2003-02-10 | 2004-09-02 | Mckenney Keith | Real-time polymerase chain reaction using large target amplicons |
| US20040170954A1 (en) | 2003-02-10 | 2004-09-02 | Mckenney Keith | Pathogen inactivation assay |
| US20040185438A1 (en) | 2003-03-10 | 2004-09-23 | Ecker David J. | Methods of detection and notification of bioagent contamination |
| US20050065813A1 (en) | 2003-03-11 | 2005-03-24 | Mishelevich David J. | Online medical evaluation system |
| US6977370B1 (en) * | 2003-04-07 | 2005-12-20 | Ciphergen Biosystems, Inc. | Off-resonance mid-IR laser desorption ionization |
| US8046171B2 (en) | 2003-04-18 | 2011-10-25 | Ibis Biosciences, Inc. | Methods and apparatus for genetic evaluation |
| EP1618216A2 (en) * | 2003-04-25 | 2006-01-25 | Sequenom, Inc. | Fragmentation-based methods and systems for de novo sequencing |
| US8057993B2 (en) | 2003-04-26 | 2011-11-15 | Ibis Biosciences, Inc. | Methods for identification of coronaviruses |
| WO2005009202A2 (en) | 2003-05-12 | 2005-02-03 | Isis Pharmaceuticals, Inc. | Automatic identification of bioagents |
| US7964343B2 (en) | 2003-05-13 | 2011-06-21 | Ibis Biosciences, Inc. | Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| US8158354B2 (en) | 2003-05-13 | 2012-04-17 | Ibis Biosciences, Inc. | Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| US6939367B2 (en) | 2003-06-24 | 2005-09-06 | Fred Harrison | Apparatus for self-applied hot stone therapy |
| ATE373729T1 (en) | 2003-07-03 | 2007-10-15 | Danmarks Og Groenlands Geol Un | METHOD FOR SELECTIVE DETECTION OF A TARGET NUCLEIC ACID |
| AU2003257013A1 (en) | 2003-07-29 | 2005-03-07 | Sigma Aldrich Co. | Methods and compositions for amplification of dna |
| JP4304292B2 (en) | 2003-07-30 | 2009-07-29 | 日本電気株式会社 | Mobile communication system, mobile communication terminal, power control method used therefor, and program thereof |
| KR100632429B1 (en) | 2003-08-01 | 2006-10-09 | 프로테온 주식회사 | Screening system of reassortant influenza viruses using primer dependent multiplex RT-PCR |
| US20060240412A1 (en) | 2003-09-11 | 2006-10-26 | Hall Thomas A | Compositions for use in identification of adenoviruses |
| US20050142584A1 (en) | 2003-10-01 | 2005-06-30 | Willson Richard C. | Microbial identification based on the overall composition of characteristic oligonucleotides |
| WO2005036369A2 (en) | 2003-10-09 | 2005-04-21 | Isis Pharmaceuticals, Inc. | Database for microbial investigations |
| FR2861743B1 (en) | 2003-11-04 | 2007-10-19 | Univ Aix Marseille Ii | MOLECULAR IDENTIFICATION OF BACTERIA OF THE GENUS CORYNEBACTERIUM |
| US8163895B2 (en) | 2003-12-05 | 2012-04-24 | Ibis Biosciences, Inc. | Compositions for use in identification of orthopoxviruses |
| WO2005062770A2 (en) | 2003-12-19 | 2005-07-14 | Novakoff James L | Method for conducting pharmacogenomics-based studies |
| EP2251441B1 (en) | 2004-02-10 | 2013-05-08 | F. Hoffmann-La Roche AG | Detection of parvovirus B19 |
| US7666592B2 (en) | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
| WO2006071241A2 (en) | 2004-02-18 | 2006-07-06 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of bacteria |
| US8119336B2 (en) | 2004-03-03 | 2012-02-21 | Ibis Biosciences, Inc. | Compositions for use in identification of alphaviruses |
| US7312036B2 (en) | 2004-03-22 | 2007-12-25 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of viral hemorrhagic fever viruses |
| EP2458619B1 (en) * | 2004-05-24 | 2017-08-02 | Ibis Biosciences, Inc. | Mass spectrometry with selective ion filtration by digital thresholding |
| US20050266411A1 (en) | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
| US7627437B2 (en) | 2005-01-14 | 2009-12-01 | Idaho Research Foundation | Categorization of microbial communities |
| DE102005008583B4 (en) | 2005-02-24 | 2007-10-25 | Johannes-Gutenberg-Universität Mainz | A method of typing an individual by short tandem repeat (STR) loci of the genomic DNA |
| CA2600184A1 (en) | 2005-03-03 | 2006-09-08 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of adventitious viruses |
| EP1891244B1 (en) | 2005-04-13 | 2010-10-06 | Ibis Biosciences, Inc. | Compositions for use in identification of adenoviruses |
| CA2607468A1 (en) | 2005-04-21 | 2006-11-02 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of bacteria |
| US7230235B2 (en) * | 2005-05-05 | 2007-06-12 | Palo Alto Research Center Incorporated | Automatic detection of quality spectra |
| US8026084B2 (en) | 2005-07-21 | 2011-09-27 | Ibis Biosciences, Inc. | Methods for rapid identification and quantitation of nucleic acid variants |
| US20070026435A1 (en) | 2005-07-28 | 2007-02-01 | Polysciences, Inc. | Hydroxysilane functionalized magnetic particles and nucleic acid separation method |
| WO2008104002A2 (en) | 2007-02-23 | 2008-08-28 | Ibis Biosciences, Inc. | Methods for rapid forensic dna analysis |
| US20100204266A1 (en) | 2007-03-23 | 2010-08-12 | Ibis Biosciences, INC | Compositions for use in identification of mixed populations of bioagents |
| JP5276999B2 (en) | 2009-01-19 | 2013-08-28 | 矢崎総業株式会社 | Case fixing structure |
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- 2005-05-24 US US11/136,134 patent/US7714275B2/en not_active Expired - Fee Related
- 2005-05-24 EP EP05753037A patent/EP1766659A4/en not_active Withdrawn
- 2005-05-24 JP JP2007515292A patent/JP4810533B2/en not_active Expired - Fee Related
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| JP2008500539A (en) | 2008-01-10 |
| WO2005117270A3 (en) | 2007-02-15 |
| WO2005117270A2 (en) | 2005-12-08 |
| US20160071710A1 (en) | 2016-03-10 |
| US7714275B2 (en) | 2010-05-11 |
| EP2458619A1 (en) | 2012-05-30 |
| EP1766659A4 (en) | 2009-09-30 |
| ES2641832T3 (en) | 2017-11-14 |
| JP4810533B2 (en) | 2011-11-09 |
| US20130092830A1 (en) | 2013-04-18 |
| US20100127165A1 (en) | 2010-05-27 |
| CA2567839C (en) | 2011-06-28 |
| EP1766659A2 (en) | 2007-03-28 |
| US8173957B2 (en) | 2012-05-08 |
| US9449802B2 (en) | 2016-09-20 |
| US20050270191A1 (en) | 2005-12-08 |
| EP2458619B1 (en) | 2017-08-02 |
| US8987660B2 (en) | 2015-03-24 |
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