CA2569542A1 - A delivery system - Google Patents
A delivery system Download PDFInfo
- Publication number
- CA2569542A1 CA2569542A1 CA002569542A CA2569542A CA2569542A1 CA 2569542 A1 CA2569542 A1 CA 2569542A1 CA 002569542 A CA002569542 A CA 002569542A CA 2569542 A CA2569542 A CA 2569542A CA 2569542 A1 CA2569542 A1 CA 2569542A1
- Authority
- CA
- Canada
- Prior art keywords
- delivery system
- core
- membrane
- cyclodextrins
- regulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
The present invention relates to a delivery system comprising a core and a membrane encasing said core, wherein said core and membrane consist essentially of an elastomer composition and said core comprises at least one therapeutically active agent. The delivery system is characterized in that the membrane comprises at least one regulating agent. The invention also relates to a method for controlling the release of at least one therapeutically active agent from a delivery system.
Claims (9)
1. A delivery system comprising a core and a membrane encas-ing said core, wherein said core and membrane consist essentially of an elastomer composition and said core comprises at least one therapeutically active agent, characterized in that the membrane comprises at least one regulating agent.
2. The delivery system according to claim 1, characterized in that said regulating agent is selected from the group consisting of carbo-hydrates, cyclodextrins and modified cyclodextrins.
3. The delivery system according to claim 2, characterized in that said regulating agent is selected from the group consisting of alpha cyclodextrins, beta cyclodextrins, gamma cyclodextrins, hydroxypro-pyl cyclodextrins, maltosyl .beta.-cyclodextrin and .beta.-cyclodextrin sulfobu-tyl.
4. The delivery system according to any of the previous claims, characterized in that the membrane comprises one regulating agent.
5. The delivery system according to any of the claims 1-3, -characterized in that the membrane comprises two regulating agents.
6. The delivery system according to claim 5, characterized in that said regulating agents are present in separate parts of said mem-brane.
7. The delivery system according to claim 5 or 6, characterized in that said regulating agents are present in separate layers of said membrane.
8. The delivery system according to any of the previous claims, characterized in that said delivery system is selected from the group consisting of transdermal patches, implants for releasing a therapeutically active agent in the body tissues, intravaginal rings, intracervical and intrauterine devices.
9. A method for controlling the release of at least one therapeuti-cally active agent from a delivery system comprising a core and a membrane encasing said core, wherein said core and membrane consist essentially of an elastomer composition and said core com-prises said at least one therapeutically active agent, characterized in that said regulation is performed by at least one regulating agent comprised in the membrane of said delivery system.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04396049.1 | 2004-07-13 | ||
EP04396049A EP1629844B2 (en) | 2004-07-13 | 2004-07-13 | A longterm delivery system with controlled initial burst |
PCT/FI2005/000314 WO2006005794A1 (en) | 2004-07-13 | 2005-07-05 | A delivery system |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2569542A1 true CA2569542A1 (en) | 2006-01-19 |
CA2569542C CA2569542C (en) | 2012-10-09 |
Family
ID=34932022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2569542A Expired - Fee Related CA2569542C (en) | 2004-07-13 | 2005-07-05 | A delivery system |
Country Status (24)
Country | Link |
---|---|
US (1) | US7850986B2 (en) |
EP (1) | EP1629844B2 (en) |
JP (1) | JP4881861B2 (en) |
KR (1) | KR20070035032A (en) |
CN (1) | CN1984639A (en) |
AT (1) | ATE372772T1 (en) |
AU (1) | AU2005261682B2 (en) |
BR (1) | BRPI0513295A (en) |
CA (1) | CA2569542C (en) |
DE (1) | DE602004008912T3 (en) |
DK (1) | DK1629844T4 (en) |
ES (1) | ES2293193T5 (en) |
HK (1) | HK1086751A1 (en) |
IL (1) | IL179846A (en) |
MX (1) | MX2007000433A (en) |
NO (1) | NO334931B1 (en) |
NZ (1) | NZ551823A (en) |
PL (1) | PL1629844T5 (en) |
PT (1) | PT1629844E (en) |
RU (1) | RU2412693C2 (en) |
SI (1) | SI1629844T1 (en) |
UA (1) | UA91337C2 (en) |
WO (1) | WO2006005794A1 (en) |
ZA (1) | ZA200610473B (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1629844T4 (en) | 2004-07-13 | 2012-05-29 | Bayer Schering Pharma Oy | Retarded administration system with controlled initial onset |
WO2006078320A2 (en) * | 2004-08-04 | 2006-07-27 | Brookwood Pharmaceuticals, Inc. | Methods for manufacturing delivery devices and devices thereof |
US8124601B2 (en) * | 2007-11-21 | 2012-02-28 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
WO2009085952A1 (en) | 2007-12-20 | 2009-07-09 | Brookwood Pharmaceuticals, Inc. | Process for preparing microparticles having a low residual solvent volume |
US20100158980A1 (en) * | 2008-12-18 | 2010-06-24 | Casey Kopczynski | Drug delivery devices for delivery of therapeutic agents |
US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
WO2013013172A1 (en) * | 2011-07-20 | 2013-01-24 | The University Of Utah Research Foundation | Intravaginal devices for drug delivery |
MX351280B (en) | 2012-01-18 | 2017-10-06 | Worldwide Innovative Healthcare Inc | Modifiable occlusive skin dressing. |
AR089765A1 (en) | 2012-01-23 | 2014-09-17 | Bayer Oy | A SYSTEM FOR THE SUPPLY OF A PHARMACO |
US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
CN105310974B (en) * | 2014-08-01 | 2019-08-23 | 山东绿叶制药有限公司 | The implant of rotigotine and its derivative or its pharmaceutical salts |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
US3832252A (en) | 1970-09-29 | 1974-08-27 | T Higuchi | Method of making a drug-delivery device |
NZ217844A (en) | 1985-10-11 | 1989-10-27 | Sumitomo Pharma | A sustained release pharmaceutical composition containing silicone elastomer and an albumin |
DE3879031T2 (en) † | 1987-08-08 | 1993-06-24 | Akzo Nv | CONCEPTUAL IMPLANT. |
US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
RU2088166C1 (en) | 1993-08-10 | 1997-08-27 | Педдер Валерий Викторович | Method and device for carrying out contraception |
BR9507313B8 (en) | 1994-04-08 | 2016-06-07 | Atrix Lab Inc | liquid release composition suitable for the formation of a controlled release implant, polymeric system, biodegradable microporous film dressing, and precursor of a controlled release implant for implantation in an individual |
US5492947A (en) * | 1994-06-23 | 1996-02-20 | Aspen Research Corporation | Barrier material comprising a thermoplastic and a compatible cyclodextrin derivative |
GB2290964A (en) | 1994-07-08 | 1996-01-17 | Arto Olavi Urtti | Transdermal drug delivery system |
FI97947C (en) | 1994-09-27 | 1997-03-25 | Leiras Oy | Process for the preparation of a pharmaceutical composition |
GB9522403D0 (en) † | 1995-11-01 | 1996-01-03 | Hoechst Roussel Ltd | Intravaginal drug delivery device |
US6416778B1 (en) * | 1997-01-24 | 2002-07-09 | Femmepharma | Pharmaceutical preparations and methods for their regional administration |
US6039968A (en) * | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
NZ330596A (en) * | 1998-06-05 | 2001-02-23 | Dec Res | Intravaginal devices allowing for increased uptake of active ingredients |
WO1999061062A1 (en) † | 1998-05-29 | 1999-12-02 | Massachusetts Institute Of Technology | Cyclodextrin complexes |
CA2380111A1 (en) | 1999-08-03 | 2001-02-08 | Smith & Nephew, Inc. | Controlled release implantable devices |
ATE355824T1 (en) * | 2000-01-11 | 2007-03-15 | Roland Bodmeier | IMPLANTATION KIT CONTAINING A CARRIER PHASE AND A SOLVENT |
US6299894B1 (en) | 2000-05-10 | 2001-10-09 | Leiras Oy | Drug delivery device, especially for the delivery of gestodene |
AU2002210580A1 (en) | 2000-10-20 | 2002-04-29 | Leiras Oy | Drug delivery system |
WO2002076426A2 (en) | 2001-03-27 | 2002-10-03 | Galen (Chemicals) Limited | Intravaginal drug delivery devices for the administration of an antimicrobial agent |
CN1210079C (en) | 2001-04-25 | 2005-07-13 | 上海市计划生育科学研究所 | Medicine for vaginal ring and its application |
AU2002313517B2 (en) | 2001-08-31 | 2007-09-06 | Bayer Schering Pharma Oy | Drug delivery system |
US8404272B2 (en) * | 2003-06-26 | 2013-03-26 | Poly-Med, Inc. | Fiber-reinforced composite rings for intravaginal controlled drug delivery |
WO2005004837A1 (en) † | 2003-07-10 | 2005-01-20 | Galen (Chemicals) Limited | Intravaginal drug delivery devices |
MXPA06010905A (en) * | 2004-03-24 | 2007-03-08 | Organon Nv | Drug delivery system based on polyethylene vinylacetate copolymers. |
DK1629844T4 (en) | 2004-07-13 | 2012-05-29 | Bayer Schering Pharma Oy | Retarded administration system with controlled initial onset |
-
2004
- 2004-07-13 DK DK04396049.1T patent/DK1629844T4/en active
- 2004-07-13 PL PL04396049T patent/PL1629844T5/en unknown
- 2004-07-13 EP EP04396049A patent/EP1629844B2/en active Active
- 2004-07-13 PT PT04396049T patent/PT1629844E/en unknown
- 2004-07-13 ES ES04396049T patent/ES2293193T5/en active Active
- 2004-07-13 SI SI200430465T patent/SI1629844T1/en unknown
- 2004-07-13 DE DE602004008912T patent/DE602004008912T3/en active Active
- 2004-07-13 AT AT04396049T patent/ATE372772T1/en active
-
2005
- 2005-05-07 UA UAA200613637A patent/UA91337C2/en unknown
- 2005-07-05 BR BRPI0513295-9A patent/BRPI0513295A/en not_active IP Right Cessation
- 2005-07-05 CN CNA2005800232239A patent/CN1984639A/en active Pending
- 2005-07-05 MX MX2007000433A patent/MX2007000433A/en active IP Right Grant
- 2005-07-05 NZ NZ551823A patent/NZ551823A/en not_active IP Right Cessation
- 2005-07-05 CA CA2569542A patent/CA2569542C/en not_active Expired - Fee Related
- 2005-07-05 ZA ZA200610473A patent/ZA200610473B/en unknown
- 2005-07-05 KR KR1020077000571A patent/KR20070035032A/en not_active Application Discontinuation
- 2005-07-05 AU AU2005261682A patent/AU2005261682B2/en not_active Ceased
- 2005-07-05 US US11/631,873 patent/US7850986B2/en not_active Expired - Fee Related
- 2005-07-05 WO PCT/FI2005/000314 patent/WO2006005794A1/en active Application Filing
- 2005-07-05 JP JP2007520845A patent/JP4881861B2/en not_active Expired - Fee Related
- 2005-07-05 RU RU2006145900/15A patent/RU2412693C2/en not_active IP Right Cessation
-
2006
- 2006-06-16 HK HK06106904A patent/HK1086751A1/en not_active IP Right Cessation
- 2006-12-05 IL IL179846A patent/IL179846A/en not_active IP Right Cessation
-
2007
- 2007-02-12 NO NO20070805A patent/NO334931B1/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20220301 |
|
MKLA | Lapsed |
Effective date: 20200831 |