CA2593122A1 - Anti a beta antibody formulation - Google Patents

Anti a beta antibody formulation Download PDF

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Publication number
CA2593122A1
CA2593122A1 CA002593122A CA2593122A CA2593122A1 CA 2593122 A1 CA2593122 A1 CA 2593122A1 CA 002593122 A CA002593122 A CA 002593122A CA 2593122 A CA2593122 A CA 2593122A CA 2593122 A1 CA2593122 A1 CA 2593122A1
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Canada
Prior art keywords
antibody
formulation
beta
humanized
mannitol
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CA002593122A
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French (fr)
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CA2593122C (en
Inventor
Donna Luisi
Nicholas W. Warne
Angela Kantor
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Janssen Sciences Ireland UC
Wyeth LLC
Original Assignee
Neuralab Limited
Wyeth
Donna Luisi
Nicholas W. Warne
Angela Kantor
Elan Pharma International Limited
Crimagua Limited
Janssen Alzheimer Immunotherapy
Wyeth Llc
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Application filed by Neuralab Limited, Wyeth, Donna Luisi, Nicholas W. Warne, Angela Kantor, Elan Pharma International Limited, Crimagua Limited, Janssen Alzheimer Immunotherapy, Wyeth Llc filed Critical Neuralab Limited
Publication of CA2593122A1 publication Critical patent/CA2593122A1/en
Application granted granted Critical
Publication of CA2593122C publication Critical patent/CA2593122C/en
Expired - Fee Related legal-status Critical Current
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4172Imidazole-alkanecarboxylic acids, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Abstract

The present invention provides formulations for maintaining the stability of A.beta. binding polypeptides, for example, A.beta. antibodies. Exemplary formulations include a tonicity agent such as mannitol and a buffering agent or amino acid such as histidine. Other exemplary formulations include an antioxidant in a sufficient amount as to inhibit by-product formation, for example, the formation of high molecular weight polypeptide aggregates, low molecular weight polypeptide degradation fragments, and mixtures thereof. The formulations of the invention optionally comprise a tonicity agent, such as mannitol, and a buffering agent or amino acid such as histidine. The formulations are suitable for several different routes of administration.

Claims (86)

1. A stabilized formulation comprising at least one A.beta. binding polypeptide, at least one tonicity agent, wherein the tonicity agent is present in an amount sufficient to render the formulation suitable for administration, and at least one buffering agent in an amount sufficient to maintain a physiologically suitable pH.
2. The formulation of claim 1, further comprising at least one antioxidant.
3. The formulation of claim 2, wherein at least one antioxidant is methionine.
4. The formulation of claim 1, wherein at least one tonicity agent is mannitol.
5. The formulation of claim 4, wherein at least one tonicity agent is NaCl.
6. The formulation of claim 1, wherein at least one buffering agent is histidine.
7. The formulation of claim 1, wherein at least one buffering agent is succinate.
8. The formulation of claim 1, wherein at least one buffering agent is sodium phosphate.
9. The formulation of claim 1, further coinprising at least one stabilizer.
10. The formulation of claim 9, wherein at least one stabilizer is polysorbate 80.
11. The formulation of claim 1, wherein at least one A.beta. binding polypeptide is selected from the group consisting of an anti A.beta. antibody, an anti A.beta. antibody Fv fragment, an anti A.beta. antibody Fab fragment, an anti A.beta. antibody Fab'(2) fragment, an anti A.beta. antibody Fd fragment, a single-chain anti A.beta.
antibody (scFv), a single domain anti A.beta. antibody fragment (Dab), a beta-pleated sheet polypeptide comprising at least one antibody complementarity determining region (CDR) from an anti A.beta. antibody, and a non-globular polypeptide comprising at least one antibody CDR from an anti A.beta. antibody.
12. The formulation of claim 11, wherein at least one A.beta. binding polypeptide is an anti A.beta. antibody.
13. The formulation of claim 12, wherein the anti A.beta. antibody specifically binds to an epitope within residues selected from the group consisting of 1-7, 1-5, 3-7, 3-6, 13-28, 15-24, 16-24, 16-21, 19-22, 33-40, and 33-42 of A.beta..
14. The formulation of claim 13, wherein the anti A.beta. antibody specifically binds to an epitope within residues 1-7.
15. The formulation of claim 13, wherein the anti A.beta. antibody specifically binds to an epitope within residues 1-5.
16. The formulation of claim 13, wherein the anti A.beta. antibody specifically binds to an epitope within residues 3-6.
17. The formulation of claim 13, wherein the anti A.beta. antibody specifically binds to an epitope within residues 3-7.
18. The formulation of claim 13, wherein the anti A.beta. antibody specifically binds to an epitope within residues 13-28.
19. The formulation of claim 13, wherein the anti A.beta. antibody specifically binds to an epitope within residues 16-24.
20. The formulation of claim 13, wherein the anti A.beta. antibody specifically binds to an epitope within residues 16-21.
21. The formulation of claim 13, wherein the anti A.beta. antibody specifically binds to an epitope within residues 19-22.
22. The formulation of claim 12, wherein the anti A.beta. antibody is selected from the group consisting of a humanized 3D6 antibody, a humanized 10D5 antibody, a humanized 12B4 antibody, a humanized 266 antibody, a humanized 12A11 antibody, and a humanized 15C11 antibody.
23. The formulation of claim 22, further comprising a stabilizer and an antioxidant.
24. The formulation of claim 23, wherein the stabilizer is polysorbate 80, the antioxidant is methionine, the tonicity agent is mannitol, sorbitol or NaC1, and the buffering agent is histidine.
25. The formulation of claim 22, wherein the formulation is a lyophilized formulation.
26. The formulation of claim 22, wherein the formulation is a liquid formulation.
27. The formulation of claim 22, wherein the antibody is of isotype human IgG1.
28. The formulation of claim 22, wherein the antibody is of isotype human IgG4.
29. The formulation of claim 12, wherein the anti A.beta. antibody is present at a concentration of about 0.1 mg/ml to about 60 mg/ml.
30. The formulation of claim 12, wherein the anti A.beta. antibody is present at a concentration of about 20 mg/ml.
31. The formulation of claim 12, wherein the anti A.beta. antibody is present at a concentration of about 10 mg/ml.
32. The formulation of claim 23, wherein at least one tonicity agent is D-mannitol at a concentration of about 1% w/v to about 10% w/v.
33. The formulation of claim 32, wherein the concentration of D-mannitol is about 2% w/v to about 6% w/v.
34. The formulation of claim 23, wherein at least one buffering agent is histidine at a concentration of about 0.1 mM to about 25 mM.
35. The formulation of claim 23, wherein the formulation has a pH of about 5.5 to about 6.5.
36. The formulation of claim 22, wherein the anti A.beta. antibody is a humanized 3D6 antibody.
37. The formulation of claim 22, wherein the anti A.beta. antibody is a humanized 12A11 antibody.
38. The formulation of claim 22, wherein the anti A.beta. antibody is a humanized 266 antibody.
39. The formulation of claim 22, wherein the anti A.beta. antibody is a humanized 15C11 antibody.
40. A formulation stable for at least about 12 months at a temperature of above freezing to about 10°C and having a pH of about 5.5 to about 6.5, comprising:

i. at least one A.beta. antibody at a concentration of about 1 mg/ml to about 30 mg/ml;

ii. mannitol at a concentration of about 4% w/v or NaCl at a concentration of about 150 mM;

iii. about 5 mM to about 10 mM histidine or succinate; and iv. 10 mM methionine.
41. The formulation of claim 40, wherein the formulation is stable for at least about 24 months at a temperature of about 2°C to 8°C, and comprises polysorbate 80 at a concentration of about 0.001 % w/v to about 0.01 % w/v.
42. The formulation of claim 40, wherein the formulation has a pH of about 6.0 to about 6.5 and comprises about 10 mg/ml A.beta. antibody, about 10 mM histidine and about 4% w/v mannitol and about .005% w/v polysorbate 80.
43. The formulation of claim 40, wherein the formulation has a pH of about 6.0 to about 6.2 and comprises about 20 mg/ml A.beta. antibody, about 10 mM
histidine, about 4% w/v mannitol and about .005% w/v polysorbate 80.
44. The formulation of claim 40, wherein the formulation has a pH of about 6.0 to about 6.2 and comprises about 30 mg/ml A.beta. antibody, about 10 mM
histidine, about 4% w/v mannitol and about .005% w/v polysorbate 80.
45. The formulation of claim 40, wherein the A.beta. antibody is selected from the group consisting of a humanized 3D6 antibody, a humanized 10D5 antibody, a humanized 12B4 antibody, a humanized 266 antibody, a humanized 12A11 antibody, and a humanized 15C11 antibody.
46. The formulation of claim 40, wherein the formulation has a pH of about 6.0 to 6.5 and comprises about 10 mM histidine, about 4% w/v mannitol and about 2 mg/ml to about 20 mg/ml of an A.beta. antibody selected from the group consisting of a humanized 3D6 antibody, a humanized 10D5 antibody, a humanized 12B4 antibody, and a humanized 12A11 antibody.
47. The formulation of claim 40, wherein the formulation has a pH of about 6.0 to 6.5 and comprises about 10 mM histidine, about 150 mM NaCl and about 2 mg/ml to about 20 mg/ml of an A.beta. antibody selected from the group consisting of a humanized 12B4 antibody, and a humanized 12A11 antibody.
48. The formulation of claim 40, wherein the formulation has a pH of about 6.0 to 6.5 and comprises about 10 mM histidine, about 4% w/v mannitol and about 2 mg/ml to about 20 mg/ml of an A.beta. antibody selected from the group consisting of a humanized 266 antibody and a humanized 15C11 antibody.
49. A formulation stable for at least about 24 months at a temperature of about 2°C
to about 8°C and having a pH of about 5.5 to about 6.5, comprising about 2 mg/ml to about 23 mg/ml of a humanized 3D6 antibody, about 10 mM histidine and about 10 mM methionine.
50. The formulation of claim 49, further comprising about 4% w/v mannitol.
51. The formulation of claim 49, further comprising polysorbate 80 at a concentration of about 0.001% w/v to about 0.01 % w/v.
52. The formulation of claim 51, comprising about 0.005% w/v polysorbate 80.
53. The formulation of claim 49, wherein the humanized 3D6 antibody is present at a concentration of about 17 mg/ml to about 23 mg/ml.
54. A formulation stable for at least about 24 months at a temperature of about 2°C to about 8°C and having a pH of about 5.5 to about 6.5, comprising about 2 mg/ml to about 23 mg/ml of a humanized 3D6 antibody, about 10 mM succinate, about 10 mM methionine, about 4% w/v mannitol and about 0.005% w/v polysorbate 80.
55. A formulation stable for at least about 24 months at a temperature of about 2°C to about 8°C and having a pH of about 6.0 to about 6.5, comprising about 2 mg/ml to about 30 mg/ml of a humanized 266 antibody, about 10 mM histidine and about 10 mM methionine.
56. The formulation of claim 55, further comprising about 4% w/v mannitol.
57. The formulation of claim 55, further comprising polysorbate 80 at a concentration of about 0.001% w/v to about 0.01% w/v.
58. A formulation stable for at least about 24 months at a temperature of about 2°C to about 8°C and having a pH of about 6.0 to about 6.5, comprising about 2 mg/ml to about 30 mg/ml of a humanized 12A11 antibody, about 10 mM histidine and about mM methionine.
59. The formulation of claim 58, further comprising about 150 mM NaCl.
60. The formulation of claim 58, further comprising polysorbate 80 at a concentration of about 0.001% w/v to about 0.01% w/v.
61. A formulation stable for at least about 24 months at a temperature of about 2°C to about 8°C and having a pH of about 6.0 to about 6.5, comprising about 2 mg/ml to about 20 mg/ml of a humanized 12A11 antibody, about 5 mM histidine, about 10 mM methionine, about 4% w/v mannitol and about 0.005% w/v polysorbate 80.
62. A formulation stable when thawed from about -50°c to about -80°c, comprising about 40 to about 60 mg/ml of an anti A.beta. antibody, about 1.0 mg/ml to about 2.0 mg/ml histidine, about 1.0mg/ml to 2.0 mg/ml methionine and about 0.05 mg/ml polysorbate 80, wherein the formulation has a pH of about 6Ø
63. The formulation of claim 62, wherein mannitol is excluded.
64. The formulation of claim 63, wherein the A.beta. antibody is a humanized antibody.
65. The formulation of claim 63, wherein the A.beta. antibody is a humanized antibody.
66. A formulation comprising about 20 mg/mL anti A.beta. antibody, about 10 mM
L-histidine, about 10 mM methionine, about 4% mannitol and having a pH of about 6.
67. A formulation comprising about 30 mg/mL anti A.beta. antibody, about 10 mM

succinate, about 10 mM methionine, about 6% mannitol and having a pH of about 6.2.
68. A formulation comprising about 20 mg/mL anti A.beta. antibody, about 10 mM
L-histidine, about 10 mM methionine, about 4% mannitol, about 0.005% polysorbate 80, and having a pH of about 6.
69. A formulation comprising about 10 mg/mL anti A.beta. antibody, about 10 mM

succinate, about 10 mM methionine, about 10% mannitol, about 0.005%
polysorbate 80, and having a pH of about 6.5.
70. A formulation comprising about 5 mg/mL to about 20 mg/mL anti A.beta.
antibody, about 5 mM to about 10 mM L-histidine, about 10 mM methionine, about 4%
mannitol, about 0.005% polysorbate 80, and having a pH of about 6.0 to about 6.5.
71. A formulation comprising about 5 mg/mL to about 20 mg/mL anti A.beta.
antibody, about 5 mM to about 10 mM L-histidine, about 10 mM methionine, about 150 mM
NaCl, about 0.005% polysorbate 80, and having a pH of about 6.0 to about 6.5.
72. A pharmaceutical unit dosage form, comprising a formulation comprising:

a. about 10 mg to about 250 mg of an anti A.beta. antibody;
b. about 4% mannitol or about 150 mM NaCl;

c. about 5 mM to about 10 mM histidine or succinate; and d. about 10 mM methionine.
73. The pharmaceutical unit dosage form of claim 72, comprising about 0.001%
to about 0.1% polysorbate 80.
74. The pharmaceutical unit dosage form of claim 73, comprising about 40 mg to about 60 mg of the anti A.beta. antibody.
75. The pharmaceutical unit dosage form of claim 73, comprising about 60 mg to about 80 mg of the anti A.beta. antibody.
76. The pharmaceutical unit dosage form of claim 73, comprising about 80 mg to about 120 mg of the anti A.beta. antibody.
77. The pharmaceutical unit dosage form of claim 73, comprising about 120 mg to about 160 mg of the anti A.beta. antibody.
78. The pharmaceutical unit dosage form of claim 73, comprising about 160 mg to about 240 mg of the anti A.beta. antibody.
79. A therapeutic product, comprising:

a. a glass vial, comprising a formulation comprising:

i. about 10 mg to about 250 mg of a humanized anti A.beta.
antibody, ii. about 4% mannitol or about 150 mM NaCl, iii. about 5 mM to about 10 mM histidine, and iv. about 10 mM methionine; and b. labeling for use comprising instructions to use the appropriate volume necessary to achieve a dose of about 0.15 mg/kg to about mg/kg.
80. The therapeutic product of claim 79, wherein the dose is about .5 mg/kg to about 3 mg/kg.
81. The therapeutic product of claim 79, wherein the dose is about 1 mg/kg to about 2 mg/kg.
82. The therapeutic product of claim 79, wherein the anti A.beta. antibody concentration is about 10 mg/ml to about 60 mg/ml.
83. The therapeutic product of claim 79, wherein the anti A.beta. antibody concentration is about 20 mg/ml.
84. The therapeutic product of claim 79, further comprising about 0.005%
polysorbate 80.
85. The therapeutic product of claim 79, wherein the use is a subcutaneous administration.
86. The therapeutic product of claim 79, wherein the use is an intravenous administration.
CA2593122A 2005-01-28 2006-01-27 Anti a beta antibody formulation Expired - Fee Related CA2593122C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64863105P 2005-01-28 2005-01-28
US60/648,631 2005-01-28
PCT/US2006/002837 WO2006083689A2 (en) 2005-01-28 2006-01-27 Anti a beta antibody formulation

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CA2593122A1 true CA2593122A1 (en) 2006-08-10
CA2593122C CA2593122C (en) 2012-03-06

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JP (1) JP4977625B2 (en)
KR (1) KR101188060B1 (en)
CN (2) CN103768009B (en)
AR (1) AR052198A1 (en)
AU (1) AU2006211184B8 (en)
BR (1) BRPI0607039A2 (en)
CA (1) CA2593122C (en)
DK (1) DK1853310T3 (en)
DO (1) DOP2006000021A (en)
EA (2) EA015147B1 (en)
ES (1) ES2391407T3 (en)
GT (1) GT200600031A (en)
HK (3) HK1108132A1 (en)
IL (1) IL184599A (en)
JO (1) JO2740B1 (en)
MX (1) MX2007009050A (en)
MY (1) MY177052A (en)
NO (1) NO20073305L (en)
NZ (1) NZ556393A (en)
PE (1) PE20060879A1 (en)
PL (1) PL1853310T3 (en)
PT (1) PT1853310E (en)
SI (1) SI1853310T1 (en)
TW (1) TWI398263B (en)
UA (1) UA87549C2 (en)
UY (1) UY29351A1 (en)
WO (1) WO2006083689A2 (en)
ZA (1) ZA200705710B (en)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI239847B (en) * 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7964192B1 (en) * 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
CA2414772C (en) * 2000-07-07 2011-06-28 Jan Naslund Prevention and treatment of alzheimer's disease
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
US20160279239A1 (en) 2011-05-02 2016-09-29 Immunomedics, Inc. Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
DE10303974A1 (en) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid β (1-42) oligomers, process for their preparation and their use
CA2513722A1 (en) * 2003-02-01 2004-08-19 Neuralab Limited Active immunization to generate antibodies to soluble a-beta
TWI374893B (en) 2003-05-30 2012-10-21 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
SE0401601D0 (en) 2004-06-21 2004-06-21 Bioarctic Neuroscience Ab Protofibril specific antibodies and uses thereof
US7807804B2 (en) * 2004-10-05 2010-10-05 Wyeth Llc Methods and compositions for improving recombinant protein production
AR052051A1 (en) 2004-12-15 2007-02-28 Neuralab Ltd AB HUMANIZED ANTIBODIES USED TO IMPROVE COGNITION
GT200600031A (en) 2005-01-28 2006-08-29 ANTI-BETA ANTIBODY FORMULATION
US20160355591A1 (en) 2011-05-02 2016-12-08 Immunomedics, Inc. Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
UY29504A1 (en) 2005-04-29 2006-10-31 Rinat Neuroscience Corp DIRECTED ANTIBODIES AGAINST BETA AMYLOID PEPTIDE AND METHODS USING THE SAME.
CA2611815A1 (en) * 2005-06-17 2006-12-28 Elan Pharma International Limited Methods of purifying anti a beta antibodies
PL1954718T3 (en) 2005-11-30 2015-04-30 Abbvie Inc Anti-a globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
WO2007064972A2 (en) 2005-11-30 2007-06-07 Abbott Laboratories Monoclonal antibodies against amyloid beta protein and uses thereof
RU2015111675A (en) 2005-12-12 2015-08-10 Ац Иммуне Са SPECIFIC IN RESPECT TO AMYLOID BETA (A BETA) 1-42 MONOCLONAL ANTIBODIES WITH THERAPEUTIC PROPERTIES
CA2635692C (en) * 2005-12-29 2013-06-18 Centocor, Inc. Human anti-il-23 antibodies, compositions, methods and uses
KR101413615B1 (en) * 2006-03-23 2014-07-18 바이오악틱 뉴로사이언스 에이비 Improved antibody selective for human protofibrils and the use thereof
WO2010044803A1 (en) * 2008-10-17 2010-04-22 Elan Pharma International Limited Treatment of amyloidogenic diseases
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
SG173385A1 (en) 2006-07-14 2011-08-29 Ac Immune S A Ch Humanized antibody against amyloid beta
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
CA2671968A1 (en) * 2006-12-11 2008-06-19 F. Hoffmann-La Roche Ag Abeta antibody parenteral formulation
EP2124952A2 (en) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
WO2008131298A2 (en) * 2007-04-18 2008-10-30 Elan Pharma International Limited Prevention and treatment of cerebral amyloid angiopathy
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
AU2008269086B2 (en) * 2007-06-25 2014-06-12 Amgen Inc. Compositions of specific binding agents to hepatocyte growth factor
JP5889529B2 (en) * 2007-07-27 2016-03-22 ヤンセン・サイエンシズ・アイルランド・ユーシー Treatment of amyloidogenic diseases
WO2009037190A2 (en) * 2007-09-21 2009-03-26 F. Hoffmann-La Roche Ag Pharmaceutical formulation for il-ir antibody
CN101998863B (en) * 2007-10-05 2015-09-16 基因技术公司 The purposes of anti-amyloid beta antibody in oculopathy
ES2445590T3 (en) 2007-10-05 2014-03-04 Genentech, Inc. Use of anti-beta amyloid antibody in eye diseases
ES2612788T3 (en) * 2007-10-05 2017-05-18 Genentech, Inc. Methods and compositions for the diagnosis and treatment of amyloidosis
JO3076B1 (en) * 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap Immunotherapy regimes dependent on apoe status
AU2016208353B2 (en) * 2007-10-17 2017-07-20 Janssen Alzheimer Immunotherapy Immunotherapy regimes dependent on ApoE status
ES2499395T3 (en) 2008-05-23 2014-09-29 Siwa Corporation Procedures to facilitate regeneration
CN102123726A (en) * 2008-06-12 2011-07-13 阿费里斯股份公司 Compounds for treating symptoms associated with parkinson's disease
AU2009291865A1 (en) * 2008-09-10 2010-03-18 Genentech, Inc. Compositions and methods for the prevention of oxidative degradation of proteins
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
EP2196476A1 (en) * 2008-12-10 2010-06-16 Novartis Ag Antibody formulation
CA3101298A1 (en) 2010-03-01 2011-09-09 Bayer Healthcare Llc Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
WO2011107507A1 (en) 2010-03-03 2011-09-09 Boehringer Ingelheim International Gmbh Biparatopic abeta binding polypeptides
WO2011130377A2 (en) 2010-04-15 2011-10-20 Abbott Laboratories Amyloid-beta binding proteins
NZ606357A (en) 2010-07-30 2015-05-29 Genentech Inc Safe and functional humanized anti beta-amyloid antibody
JP6147665B2 (en) 2010-08-14 2017-06-14 アッヴィ・インコーポレイテッド Amyloid beta-binding protein
PT2616090T (en) * 2010-09-17 2023-10-16 Takeda Pharmaceuticals Co Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral ph
JO3400B1 (en) * 2010-09-30 2019-10-20 Ferring Bv Pharmaceutical composition of carbetocin
US8721571B2 (en) 2010-11-22 2014-05-13 Siwa Corporation Selective removal of cells having accumulated agents
EP2471554A1 (en) * 2010-12-28 2012-07-04 Hexal AG Pharmaceutical formulation comprising a biopharmaceutical drug
EP2697369B1 (en) 2011-03-25 2018-06-27 F.Hoffmann-La Roche Ag Novel protein purification methods
EP3311834A1 (en) * 2011-05-02 2018-04-25 Millennium Pharmaceuticals, Inc. Formulation for anti-alpha4beta7 antibody
CA2831572C (en) 2011-05-02 2019-11-26 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
UY34105A (en) 2011-06-03 2012-07-31 Lg Life Sciences Ltd STABLE LIQUID FORMULATION OF ETANERCEPT
US20140302021A1 (en) 2011-10-25 2014-10-09 Onclave Therapeutics Limited Antibody formulations and methods
US9592297B2 (en) * 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
WO2014068029A1 (en) 2012-10-31 2014-05-08 Takeda Gmbh Lyophilized formulation comprising gm-csf neutralizing compound
AR093297A1 (en) 2012-10-31 2015-05-27 Amgen Res (Munich) Gmbh LIQUID FORMULATION THAT INCLUDES A GM-CSF NEUTRALIZING COMPOUND
UA117466C2 (en) 2012-12-13 2018-08-10 Мерк Шарп Енд Доме Корп. SOLUTION FORMULATIONS OF ENGINEERED ANTI-IL-23p19 ANTIBODIES
US20140314741A1 (en) * 2013-04-18 2014-10-23 Developmen Center For Biotechnology Human Antibody against Interleukin-20 and Treatment for Inflammatory Diseases
US10745475B2 (en) 2013-08-30 2020-08-18 Takeda Gmbh Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics
TWI694836B (en) * 2014-05-16 2020-06-01 英商葛蘭素史克智慧財產管理有限公司 Antibody formulation
MA53887A (en) 2014-07-10 2021-10-27 Bioarctic Ab ENHANCED PROTOFIBRILL A-BETA BINDING ANTIBODY
CA3093383A1 (en) 2014-10-24 2016-04-28 Merck Sharp & Dohme Corp. Co-agonists of the glucagon and glp-1 receptors
US10358502B2 (en) 2014-12-18 2019-07-23 Siwa Corporation Product and method for treating sarcopenia
US9993535B2 (en) 2014-12-18 2018-06-12 Siwa Corporation Method and composition for treating sarcopenia
US11034760B2 (en) * 2015-05-07 2021-06-15 Swedish Orphen Biovitrum AG Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of CXCL9 and other biomarkers
US11091543B2 (en) 2015-05-07 2021-08-17 Swedish Orphan Biovitrum Ag Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications
AR104847A1 (en) 2015-06-17 2017-08-16 Lilly Co Eli FORMULATION OF ANTI-CGRP ANTIBODY
CR20170562A (en) 2015-06-24 2018-02-01 Hoffmann La Roche TRANSFERRINE ANTI-RECEIVER ANTIBODIES WITH DESIGNATED AFFINITY.
AR106189A1 (en) 2015-10-02 2017-12-20 Hoffmann La Roche BIESPECTIFIC ANTIBODIES AGAINST HUMAN A-b AND THE HUMAN TRANSFERRINE RECEIVER AND METHODS OF USE
CA2997801A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use
DK3337829T3 (en) 2016-02-19 2020-02-17 Siwa Corp METHOD AND COMPOSITION OF TREATMENT OF CANCER, KILLING OF METASTATIC CANCER CELLS AND PREVENTION OF CANCER METASTASE BY USING ANTIBODIES AGAINST ADVANCED GLYCING END PRODUCTS (AGE)
WO2018191718A1 (en) 2017-04-13 2018-10-18 Siwa Corporation Humanized monoclonal advanced glycation end-product antibody
GB201604124D0 (en) * 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
JP2019518763A (en) 2016-06-23 2019-07-04 シワ コーポレーション Vaccines for use in the treatment of various diseases and disorders
US10858449B1 (en) 2017-01-06 2020-12-08 Siwa Corporation Methods and compositions for treating osteoarthritis
US10995151B1 (en) 2017-01-06 2021-05-04 Siwa Corporation Methods and compositions for treating disease-related cachexia
US10925937B1 (en) 2017-01-06 2021-02-23 Siwa Corporation Vaccines for use in treating juvenile disorders associated with inflammation
US10961321B1 (en) 2017-01-06 2021-03-30 Siwa Corporation Methods and compositions for treating pain associated with inflammation
CN110352201A (en) 2017-04-03 2019-10-18 免疫医疗公司 The subcutaneous administration of antibody drug conjugate for cancer therapy
WO2018204374A1 (en) 2017-05-02 2018-11-08 Merck Sharp & Dohme Corp. Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies
JOP20190260A1 (en) 2017-05-02 2019-10-31 Merck Sharp & Dohme Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof
MX2020001851A (en) * 2017-08-22 2020-08-20 Biogen Ma Inc Pharmaceutical compositions and dosage regimens containing anti-alpha(v)beta(6) antibodies.
HUE061510T2 (en) 2017-08-22 2023-07-28 Biogen Ma Inc Pharmaceutical compositions containing anti-beta amyloid antibodies
US20190083618A1 (en) * 2017-09-19 2019-03-21 Regeneron Pharmaceuticals, Inc. Methods of reducing particle formation and compositions formed thereby
GB201721846D0 (en) * 2017-12-22 2018-02-07 Arecor Ltd Novel composition
US11518801B1 (en) 2017-12-22 2022-12-06 Siwa Corporation Methods and compositions for treating diabetes and diabetic complications
KR20210114989A (en) 2019-02-18 2021-09-24 일라이 릴리 앤드 캄파니 therapeutic antibody formulation
MX2023000949A (en) 2020-07-23 2023-02-22 Othair Prothena Ltd Anti-abeta antibodies.

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (en) 1984-08-15 1986-03-07 Res Dev Corp Of Japan Chimera monoclonal antibody and its preparation
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (en) 1984-12-04 1986-06-21 Teijin Ltd Expression of hybrid antibody gene
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
JP2727112B2 (en) * 1988-04-26 1998-03-11 コニカ株式会社 Stable peroxidase composition and stable antibody composition
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
ATE151110T1 (en) 1988-09-02 1997-04-15 Protein Eng Corp PRODUCTION AND SELECTION OF RECOMBINANT PROTEINS WITH DIFFERENT BINDING SITES
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
JPH06508511A (en) 1990-07-10 1994-09-29 ケンブリッジ アンティボディー テクノロジー リミティド Method for producing specific binding pair members
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ATE164395T1 (en) 1990-12-03 1998-04-15 Genentech Inc METHOD FOR ENRICHMENT OF PROTEIN VARIANTS WITH MODIFIED BINDING PROPERTIES
DE69233697T2 (en) 1991-03-01 2008-01-24 Dyax Corp., Cambridge Process for the development of binding microproteins
CA2108147C (en) 1991-04-10 2009-01-06 Angray Kang Heterodimeric receptor libraries using phagemids
DE4122599C2 (en) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid for screening antibodies
JP2966592B2 (en) * 1991-07-20 1999-10-25 萩原 義秀 Stabilized human monoclonal antibody preparation
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
US5358708A (en) 1993-01-29 1994-10-25 Schering Corporation Stabilization of protein formulations
US5385887A (en) 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6270757B1 (en) 1994-04-21 2001-08-07 Genetics Institute, Inc. Formulations for IL-11
US6372716B1 (en) 1994-04-26 2002-04-16 Genetics Institute, Inc. Formulations for factor IX
US5688651A (en) 1994-12-16 1997-11-18 Ramot University Authority For Applied Research And Development Ltd. Prevention of protein aggregation
AU695129B2 (en) 1995-02-06 1998-08-06 Genetics Institute, Llc Formulations for IL-12
US5786180A (en) 1995-02-14 1998-07-28 Bayer Corporation Monoclonal antibody 369.2B specific for β A4 peptide
US6685940B2 (en) * 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US5770700A (en) 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
JP2002514919A (en) 1997-04-04 2002-05-21 バイオサイト ダイアグノスティックス,インコーポレイテッド Multivalent and polyclonal libraries
WO1998056418A1 (en) 1997-06-13 1998-12-17 Genentech, Inc. Stabilized antibody formulation
US5994511A (en) 1997-07-02 1999-11-30 Genentech, Inc. Anti-IgE antibodies and methods of improving polypeptides
US6787523B1 (en) 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US6710226B1 (en) 1997-12-02 2004-03-23 Neuralab Limited Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6750324B1 (en) * 1997-12-02 2004-06-15 Neuralab Limited Humanized and chimeric N-terminal amyloid beta-antibodies
US6761888B1 (en) 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
US7588766B1 (en) 2000-05-26 2009-09-15 Elan Pharma International Limited Treatment of amyloidogenic disease
US7179892B2 (en) 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
US6905686B1 (en) 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
US6913745B1 (en) 1997-12-02 2005-07-05 Neuralab Limited Passive immunization of Alzheimer's disease
JP2002511385A (en) 1997-12-03 2002-04-16 ニューララブ リミテッド Method for suppressing β-amyloid-related changes in Alzheimer's disease
US20050059802A1 (en) 1998-04-07 2005-03-17 Neuralab Ltd Prevention and treatment of amyloidogenic disease
US20050059591A1 (en) 1998-04-07 2005-03-17 Neuralab Limited Prevention and treatment of amyloidogenic disease
US7282570B2 (en) * 1999-04-20 2007-10-16 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US6787637B1 (en) 1999-05-28 2004-09-07 Neuralab Limited N-Terminal amyloid-β antibodies
UA81216C2 (en) 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
PT1409654E (en) 1999-06-16 2008-11-25 Boston Biomedical Res Inst Immunological control of beta-amyloid levels in vivo
IL147599A0 (en) 1999-07-15 2002-08-14 Genetics Inst Formulations for il-11
IL151378A0 (en) 2000-02-24 2003-04-10 Univ Washington Humanized antibodies that sequester amyloid beta peptide
JP2003516929A (en) * 2000-06-01 2003-05-20 ニユーララブ・リミテツド Prevention and treatment of amyloidogenic diseases
PE20020574A1 (en) 2000-12-06 2002-07-02 Wyeth Corp HUMANIZED ANTIBODIES THAT RECOGNIZE THE AMYLOID PEPTIDE BETA
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
US6916745B2 (en) * 2003-05-20 2005-07-12 Fairchild Semiconductor Corporation Structure and method for forming a trench MOSFET having self-aligned features
ES2312569T3 (en) 2001-04-30 2009-03-01 Eli Lilly And Company HUMANIZED ANTIBODIES.
EP2165714B1 (en) 2001-04-30 2013-10-23 Eli Lilly And Company Humanized antibodies recognizing the beta-amyloid peptide
GB0113179D0 (en) * 2001-05-31 2001-07-25 Novartis Ag Organic compounds
JP4317010B2 (en) * 2001-07-25 2009-08-19 ピーディーエル バイオファーマ,インコーポレイティド Stable lyophilized pharmaceutical formulation of IgG antibody
WO2003016466A2 (en) * 2001-08-17 2003-02-27 Eli Lilly And Company ANTI-Aβ ANTIBODIES
EP1519740A4 (en) 2001-08-17 2005-11-09 Lilly Co Eli Rapid improvement of cognition in conditions related to a-beta
CA2466034C (en) * 2001-11-08 2012-12-18 Protein Design Labs, Inc. Stable aqueous pharmaceutical formulations of daclizumab antibodies
US20030171556A1 (en) 2001-12-13 2003-09-11 Chi-Bom Chae Beta-amyloid binding factors and inhibitors thereof
AR038568A1 (en) 2002-02-20 2005-01-19 Hoffmann La Roche ANTI-A BETA ANTIBODIES AND ITS USE
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
US7132100B2 (en) * 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
AU2003293543A1 (en) * 2002-12-13 2004-07-09 Abgenix, Inc. System and method for stabilizing antibodies with histidine
CA2513722A1 (en) 2003-02-01 2004-08-19 Neuralab Limited Active immunization to generate antibodies to soluble a-beta
ZA200507757B (en) 2003-04-04 2007-01-31 Genentech Inc High concentration antibody and protein formulations
TWI374893B (en) 2003-05-30 2012-10-21 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
HUE026000T2 (en) 2003-12-17 2016-04-28 Wyeth Llc Immunogenic peptide carrier conjugates and methods of producing same
EP2336147B1 (en) 2003-12-17 2014-04-30 Janssen Alzheimer Immunotherapy A beta immunogenic peptide carrier conjugates and methods of producing same
EP1563794B1 (en) * 2004-02-17 2007-04-25 Tyco Healthcare Group Lp Surgical stapling apparatus with locking mechanism
US7807804B2 (en) 2004-10-05 2010-10-05 Wyeth Llc Methods and compositions for improving recombinant protein production
WO2006047670A2 (en) 2004-10-26 2006-05-04 Wyeth Methods for assessing antibodies to neurodegenerative disease-associated antigens
US20060153772A1 (en) 2004-12-15 2006-07-13 Wyeth Contextual fear conditioning for predicting immunotherapeutic efficacy
EP1838854B1 (en) 2004-12-15 2012-10-31 Janssen Alzheimer Immunotherapy Antibodies that recognize Beta Amyloid Peptide
AR051800A1 (en) 2004-12-15 2007-02-07 Wyeth Corp BETA ANTIBODIES USED TO IMPROVE COGNITION
AR052051A1 (en) 2004-12-15 2007-02-28 Neuralab Ltd AB HUMANIZED ANTIBODIES USED TO IMPROVE COGNITION
US20060240486A1 (en) 2004-12-15 2006-10-26 Johnson-Wood Kelly L Immunoprecipitation-based assay for predicting in vivo efficacy of beta-amyloid antibodies
DOP2006000022A (en) 2005-01-28 2006-08-15 Wyeth Corp STABILIZED LIQUID FORMULATIONS OF POLYPTIDES
GT200600031A (en) 2005-01-28 2006-08-29 ANTI-BETA ANTIBODY FORMULATION
CA2611815A1 (en) 2005-06-17 2006-12-28 Elan Pharma International Limited Methods of purifying anti a beta antibodies
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
WO2008131298A2 (en) 2007-04-18 2008-10-30 Elan Pharma International Limited Prevention and treatment of cerebral amyloid angiopathy
JP5889529B2 (en) * 2007-07-27 2016-03-22 ヤンセン・サイエンシズ・アイルランド・ユーシー Treatment of amyloidogenic diseases
JO3076B1 (en) * 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap Immunotherapy regimes dependent on apoe status
IT1395574B1 (en) 2009-09-14 2012-10-16 Guala Dispensing Spa DISTRIBUTION DEVICE

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