CA2608471A1 - Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis - Google Patents

Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis Download PDF

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Publication number
CA2608471A1
CA2608471A1 CA002608471A CA2608471A CA2608471A1 CA 2608471 A1 CA2608471 A1 CA 2608471A1 CA 002608471 A CA002608471 A CA 002608471A CA 2608471 A CA2608471 A CA 2608471A CA 2608471 A1 CA2608471 A1 CA 2608471A1
Authority
CA
Canada
Prior art keywords
granisetron
dose
donor
reservoir
iontophoresis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002608471A
Other languages
French (fr)
Other versions
CA2608471C (en
Inventor
Carter R. Anderson
Walter L. Sembrowich
Russell L. Morris
Robert Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Travanti Pharma Inc
Original Assignee
Travanti Pharma Inc.
Carter R. Anderson
Walter L. Sembrowich
Russell L. Morris
Robert Cohen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Travanti Pharma Inc., Carter R. Anderson, Walter L. Sembrowich, Russell L. Morris, Robert Cohen filed Critical Travanti Pharma Inc.
Publication of CA2608471A1 publication Critical patent/CA2608471A1/en
Application granted granted Critical
Publication of CA2608471C publication Critical patent/CA2608471C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode

Abstract

A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.

Claims (42)

1. A disposable skin-worn device for the transdermal delivery of a plurality of doses of a charged therapeutic substance by iontophoresis comprising:

(a) a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, said donor reservoir further including a plurality of donor electrodes providing separate sources of selectively connectable reactive material for providing a plurality of successive doses of a therapeutic substance;
(b) a counter reservoir;
(c) a source of electric power connected in a circuit between said donor reservoir and said counter reservoir; and (d) a user-operable control system for controlling current flow in said circuit to enable the plurality of successive doses of said therapeutic substance to be administered from said donor reservoir.
2. A device as in claim 1 wherein said control system further comprises switch means for selectively connecting each of said plurality of donor electrodes into said circuit.
3. A device as in claim 1 wherein a circuit is completed and a first dose is provided automatically upon application of said device to a patient's skin.
4. A device as in claim 2 wherein a circuit is completed and a first dose is provided automatically upon application of said device to a patient's skin.
5. A device as in claim 1 designed to deliver two doses of said therapeutic substance.
6. A device as in claim 4 designed to deliver two doses of said therapeutic substance.
7. A device as in claim 1 wherein said control system further comprises a two-position switch and said donor reservoir contains two donor electrodes selectively connected in said circuit by said switch such that a first reactive donor electrode is connected in said circuit upon application of said skin-worn device to provide a first dose of said therapeutic substance and a second reactive donor electrode may selectively be connected by operation of said switch to provide a second dose of said therapeutic substance.
8. A device as in claim 1 wherein said therapeutic substance is granisetron.
9. A device as in claim 7 wherein said therapeutic substance is granisetron.
10. A device as in claim 8 wherein each said dose is between about 300 µg and 1000 µg.
11. A device as in claim 10 wherein each said dose is between about 300 µg and 1000 µg.
12. A device as in claim 10 wherein at least the first dose is delivered in about 1 hour.
13. A device as in claim 11 wherein at least the first dose is delivered in about 1 hour.
14. A device as in claim 8 wherein said granisetron is contained in a hydrogel formulation.
15. A device as in claim 9 wherein said granisetron is contained in a hydrogel formulation.
16. A device as in claim 10 wherein said granisetron is contained in a hydrogel formulation.
17. A device as in claim 11 wherein said granisetron is contained in a hydrogel formulation.
18. A disposable skin-worn device for the transdermal delivery of at least one dose of a charged therapeutic substance by iontophoresis, said device comprising:
(a) a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis;
(b) a counter reservoir;
(c) a source of electric power connected in a circuit between said donor reservoir and said counter reservoir; and (d) a control system for controlling current flow in said circuit to enable at least one dose of said therapeutic substance to be delivered transdermally by iontophoresis wherein said control system includes a control element comprising a sensor activated by an externally generated signal to initiate delivery of a dose of said therapeutic substance from a patch device previously applied to the body of a user.
19. A device as in claim 18 wherein said therapeutic substance is granisetron.
20. A device as in claim 19 wherein said granisetron is contained in a hydrogel formulation.
21. A device as in claim 19 wherein each said dose is between about 300 pg and 1000 pg per hour.
22. A disposable skin-worn patch device for the delivery of granisetron by iontophoresis, capable of providing a plurality of doses of granisetron to the body, comprising:
(a) a donor reservoir containing granisetron, said donor reservoir further including a source of reactive material for providing a plurality of successive doses of a granisetron;
(b) a counter reservoir;
(c) A source of electrical power; and (d) a control system for controlling administration usinga first completed circuit for supplying a primary dose of between about 300 µg and about 1000 µg of granisetron in a less than 2-hour time period upon application of the patch to the body surface, and user-operable device to allow user to self-administer sequentially an additional dose of between about 300 µg and about 1000 µg of granisetron.
23. A disposable skin-worn patch device for the delivery of granisetron by iontophoresis, which optionally provides a plurality of doses to the body, comprising:
(a) a donor reservoir containing granisetron, said donor reservoir further including a plurality of donor electrodes providing separate sources of reactive material for providing a plurality of successive doses of granisetron;
(b) a counter reservoir;
(c) A source of electrical power; and (d) a control circuit for controlling current, providing a first completed circuit including a first donor electrode for supplying a primary dose of between about 300 µg and about 1000 µg of granisetron in a less than 2-hour hour time period upon application of the patch to the body surface, and user-operable device to connect a second donor electrode in a completed circuit to administer an additional dose of between about 300 µg and about 1000 µg of granisetron.
24. A disposable skin-worn patch device for the delivery of granisetron by iontophoresis, comprising:
(a) a donor reservoir containing granisetron;
(b) a counter reservoir;
(c) a source of electrical power; and (d) a control circuit for controlling current in response to an externally generated alarm signal, providing an automated current dose supplying between about 300 µg and about 1000 µg of granisetron in a period of approximately one hour.
25. A device as in claim 22 wherein said granisetron is contained in a hydrogel formulation.
26. A device as in claim 23 wherein said granisetron is contained in a hydrogel formulation.
27. A device as in claim 24 wherein said granisetron is contained in a hydrogel formulation.
28. A device as in claim 22 wherein said granisetron is in a form that can only be delivered by iontophoresis.
29. A device as in claim 23 wherein said granisetron is in a form that can only be delivered by iontophoresis.
30. A device as in claim 24 wherein said granisetron is in a form that can only be delivered by iontophoresis.
31. A device as in claim 22 wherein said control system provides steady low level delivery of about 40 µg/hr of granisetron after said first primary dose.
32. A device as in claim 22 wherein said donor reservoir contains a single source of reactive material.
33. A device as in claim 32 wherein said control circuit electronically controls dosage administration.
34. A device as in claim 22 wherein the amount of granisetron supplied in the donor reservoir exceeds a desired total quantity to be delivered by the devices to a user.
35. A device as in claim 23 wherein the amount of granisetron supplied in the donor reservoir exceeds a desired total quantity to be delivered by the devices to a user.
36. A device as in claim 24 wherein the amount of granisetron supplied in the donor reservoir exceeds a desired total quantity to be delivered by the devices to a user.
37. A device as in claim 22 wherein the amount of granisetron supplied in the donor reservoir is at least twice a desired total quantity to be delivered by the devices to a user.
38. A device as in claim 23 wherein the amount of granisetron supplied in the donor reservoir is at least twice a desired total quantity to be delivered by the devices to a user.
39. A device as in claim 24 wherein the amount of granisetron supplied in the donor reservoir is at least twice a desired total quantity to be delivered by the devices to a user.
40. A device as in claim 18 including a user-activated switch element to enable said control system to activate said device.
41. A device as in claim 19 including a user-activated switch element to enable said control system to activate said device.
42. A device as in claim 24 wherein said control system provides steady low level delivery of about 40 µg/hr of granisetron after said first primary dose.
CA2608471A 2005-04-22 2006-03-24 Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis Expired - Fee Related CA2608471C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/112,196 US7856263B2 (en) 2005-04-22 2005-04-22 Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis
US11/112,196 2005-04-22
PCT/US2006/010781 WO2006115660A2 (en) 2005-04-22 2006-03-24 Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis

Publications (2)

Publication Number Publication Date
CA2608471A1 true CA2608471A1 (en) 2006-11-02
CA2608471C CA2608471C (en) 2010-06-08

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CA2608471A Expired - Fee Related CA2608471C (en) 2005-04-22 2006-03-24 Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis

Country Status (9)

Country Link
US (3) US7856263B2 (en)
EP (1) EP1877134B1 (en)
KR (1) KR100994631B1 (en)
CN (1) CN101203266B (en)
AU (1) AU2006240432B2 (en)
CA (1) CA2608471C (en)
ES (1) ES2529454T3 (en)
HK (1) HK1120451A1 (en)
WO (1) WO2006115660A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
US8722235B2 (en) 2004-04-21 2014-05-13 Blue Spark Technologies, Inc. Thin printable flexible electrochemical cell and method of making the same
US8029927B2 (en) 2005-03-22 2011-10-04 Blue Spark Technologies, Inc. Thin printable electrochemical cell utilizing a “picture frame” and methods of making the same
US8722233B2 (en) 2005-05-06 2014-05-13 Blue Spark Technologies, Inc. RFID antenna-battery assembly and the method to make the same
BRPI0709965C1 (en) * 2006-04-13 2011-12-20 Nupathe Inc pharmacokinetics of iontophoretic administration of sumatriptan
CN101802848A (en) 2007-07-18 2010-08-11 蓝色火花科技有限公司 Integrated electronic device and methods of making the same
US8399410B2 (en) 2007-08-06 2013-03-19 Allergan, Inc. Methods and devices for desmopressin drug delivery
CN101946347A (en) 2007-12-19 2011-01-12 蓝色火花科技有限公司 High current thin electrochemical cell and methods of making the same
ES2677548T3 (en) 2008-05-21 2018-08-03 Ferring B.V. Orodispersible desmopressin to increase the initial period of uninterrupted sleep due to nocturia
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US8155737B2 (en) * 2008-06-19 2012-04-10 Nupathe, Inc. Pharmacokinetics of iontophoretic sumatriptan administration
US8366600B2 (en) * 2008-06-19 2013-02-05 Nupathe Inc. Polyamine enhanced formulations for triptan compound iontophoresis
EA201270227A1 (en) * 2009-08-10 2012-10-30 Нюпэф Инк. METHODS OF IONOPHORETIC TREATMENT OF TIGHTNESS AND MIGRAINE
US20110087153A1 (en) * 2009-10-13 2011-04-14 Angelov Angel S Transdermal Methods And Systems For The Delivery Of Rizatriptan
US9027242B2 (en) 2011-09-22 2015-05-12 Blue Spark Technologies, Inc. Cell attachment method
US8765284B2 (en) 2012-05-21 2014-07-01 Blue Spark Technologies, Inc. Multi-cell battery
KR101759806B1 (en) 2012-11-01 2017-07-19 블루 스파크 테크놀러지스, 인크. Body temperature logging patch
US9444078B2 (en) 2012-11-27 2016-09-13 Blue Spark Technologies, Inc. Battery cell construction
WO2015053879A1 (en) * 2013-10-11 2015-04-16 Teikoku Pharma Usa, Inc. Sphingosine-1-phosphate receptor agonist iontophoretic devices and methods of using the same
US9693689B2 (en) 2014-12-31 2017-07-04 Blue Spark Technologies, Inc. Body temperature logging patch
US10849501B2 (en) 2017-08-09 2020-12-01 Blue Spark Technologies, Inc. Body temperature logging patch

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US536221A (en) * 1895-03-26 Electric switch
US4856188A (en) * 1984-10-12 1989-08-15 Drug Delivery Systems Inc. Method for making disposable and/or replenishable transdermal drug applicators
US4708716A (en) * 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
US5651768A (en) * 1983-08-18 1997-07-29 Drug Delivery Systems, Inc. Transdermal drug applicator and electrodes therefor
US5605536A (en) * 1983-08-18 1997-02-25 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
CA1262564A (en) * 1983-09-01 1989-10-31 Minoru Sasaki Iontophoresis device
US4927408A (en) * 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5496266A (en) * 1990-04-30 1996-03-05 Alza Corporation Device and method of iontophoretic drug delivery
US5088977A (en) * 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US6004309A (en) * 1990-03-30 1999-12-21 Alza Corporation Method and apparatus for controlled environment electrotransport
US5125894A (en) * 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US5084006A (en) * 1990-03-30 1992-01-28 Alza Corporation Iontopheretic delivery device
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5147297A (en) * 1990-05-07 1992-09-15 Alza Corporation Iontophoretic delivery device
DE4014913C2 (en) * 1990-05-10 1996-05-15 Lohmann Therapie Syst Lts Miniaturized transdermal therapeutic system for iontophoresis
US5158537A (en) * 1990-10-29 1992-10-27 Alza Corporation Iontophoretic delivery device and method of hydrating same
US6238381B1 (en) * 1990-11-01 2001-05-29 Robert Tapper Iontophoretic treatment system
US5224927A (en) * 1990-11-01 1993-07-06 Robert Tapper Iontophoretic treatment system
US5464387A (en) * 1991-07-24 1995-11-07 Alza Corporation Transdermal delivery device
US5310404A (en) * 1992-06-01 1994-05-10 Alza Corporation Iontophoretic delivery device and method of hydrating same
DK0643600T3 (en) * 1992-06-02 1998-06-02 Alza Corp Iontophoretic drug delivery apparatus
JP3488466B2 (en) * 1992-06-02 2004-01-19 アルザ・コーポレーション Electric drive drug delivery device
US5458569A (en) * 1993-06-08 1995-10-17 Becton Dickinson And Company Wearable iontophoresis system
US5533971A (en) * 1993-09-03 1996-07-09 Alza Corporation Reduction of skin irritation during electrotransport
US5540669A (en) * 1993-09-30 1996-07-30 Becton, Dickinson And Company Iontophoretic drug delivery system and method for using same
US6377847B1 (en) * 1993-09-30 2002-04-23 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
AU7923794A (en) * 1993-09-30 1995-04-18 Becton Dickinson & Company Iontophoretic drug delivery system and method
US5645526A (en) * 1994-09-30 1997-07-08 Becton Dickinson And Company Apparatus and method for ensuring compatibility of a reusable iontophoretic controller with an iontophoretic patch
US5697896A (en) * 1994-12-08 1997-12-16 Alza Corporation Electrotransport delivery device
US6425892B2 (en) * 1995-06-05 2002-07-30 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
JP2001516227A (en) * 1995-06-05 2001-09-25 アルザ・コーポレーション Fentanyl and sufentanil transdermal electrotransport administration devices
US6216033B1 (en) * 1996-05-22 2001-04-10 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
US7572252B1 (en) * 1995-06-07 2009-08-11 Alza Corporation Electrotransport agent delivery method and apparatus
US5954685A (en) * 1996-05-24 1999-09-21 Cygnus, Inc. Electrochemical sensor with dual purpose electrode
US6086572A (en) * 1996-05-31 2000-07-11 Alza Corporation Electrotransport device and method of setting output
US5738647A (en) * 1996-09-27 1998-04-14 Becton Dickinson And Company User activated iontophoretic device and method for activating same
US6047208A (en) * 1997-08-27 2000-04-04 Becton, Dickinson And Company Iontophoretic controller
US6059736A (en) * 1998-02-24 2000-05-09 Tapper; Robert Sensor controlled analysis and therapeutic delivery system
US6554798B1 (en) * 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US6949081B1 (en) * 1998-08-26 2005-09-27 Non-Invasive Technology, Inc. Sensing and interactive drug delivery
ATE343411T1 (en) 1998-08-31 2006-11-15 Travanti Pharma Inc CONTROLLED MEDICATION DOSING DEVICE
US6597946B2 (en) * 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
US6148232A (en) * 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6611706B2 (en) * 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6477410B1 (en) * 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US7127285B2 (en) * 1999-03-12 2006-10-24 Transport Pharmaceuticals Inc. Systems and methods for electrokinetic delivery of a substance
EP1171195B1 (en) * 1999-04-16 2005-03-16 Johnson & Johnson Consumer Companies, Inc. Electrotransport delivery system comprising internal sensors
US6421561B1 (en) 1999-12-30 2002-07-16 Birch Point Medical, Inc. Rate adjustable drug delivery system
JP2004504585A (en) * 2000-07-14 2004-02-12 トランスフォーム　ファーマシューティカルズ，インコーポレーティッド． Systems and methods for optimizing tissue barrier transport of compounds
US6653014B2 (en) * 2001-05-30 2003-11-25 Birch Point Medical, Inc. Power sources for iontophoretic drug delivery systems
US7047069B2 (en) * 2002-02-04 2006-05-16 Ceramatec, Inc. Iontophoretic fluid delivery device
EP3061492B1 (en) * 2002-03-11 2018-09-19 Nitto Denko Corporation Transdermal drug delivery patch system
US6801804B2 (en) * 2002-05-03 2004-10-05 Aciont, Inc. Device and method for monitoring and controlling electrical resistance at a tissue site undergoing iontophoresis
US7371229B2 (en) * 2003-01-28 2008-05-13 Felix Theeuwes Dual electrode advanced electrochemical delivery system
US6745071B1 (en) * 2003-02-21 2004-06-01 Birch Point Medical, Inc. Iontophoretic drug delivery system

Also Published As

Publication number Publication date
WO2006115660A3 (en) 2007-11-15
US8463373B2 (en) 2013-06-11
HK1120451A1 (en) 2009-04-03
AU2006240432B2 (en) 2010-08-19
KR100994631B1 (en) 2010-11-15
ES2529454T3 (en) 2015-02-20
US20130245537A1 (en) 2013-09-19
AU2006240432A1 (en) 2006-11-02
KR20080009723A (en) 2008-01-29
EP1877134A4 (en) 2012-12-12
US20110087154A1 (en) 2011-04-14
EP1877134B1 (en) 2014-12-03
US20060253061A1 (en) 2006-11-09
CN101203266A (en) 2008-06-18
CN101203266B (en) 2012-04-04
EP1877134A2 (en) 2008-01-16
CA2608471C (en) 2010-06-08
WO2006115660A2 (en) 2006-11-02
US9764130B2 (en) 2017-09-19
US7856263B2 (en) 2010-12-21

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