CA2623752C - Lens delivery system cartridge and method of manufacture - Google Patents

Lens delivery system cartridge and method of manufacture Download PDF

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Publication number
CA2623752C
CA2623752C CA2623752A CA2623752A CA2623752C CA 2623752 C CA2623752 C CA 2623752C CA 2623752 A CA2623752 A CA 2623752A CA 2623752 A CA2623752 A CA 2623752A CA 2623752 C CA2623752 C CA 2623752C
Authority
CA
Canada
Prior art keywords
cartridge
nozzle
delivery system
straight portion
lens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2623752A
Other languages
French (fr)
Other versions
CA2623752A1 (en
Inventor
David A. Downer
Kyle Brown
Sushant Muchhala
Tu Cam Tran
Dengzhu Yan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
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Application filed by Alcon Inc filed Critical Alcon Inc
Publication of CA2623752A1 publication Critical patent/CA2623752A1/en
Application granted granted Critical
Publication of CA2623752C publication Critical patent/CA2623752C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1662Instruments for inserting intraocular lenses into the eye
    • A61F2/1678Instruments for inserting intraocular lenses into the eye with a separate cartridge or other lens setting part for storage of a lens, e.g. preloadable for shipping
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/0025Preventing defects on the moulded article, e.g. weld lines, shrinkage marks
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/0046Details relating to the filling pattern or flow paths or flow characteristics of moulding material in the mould cavity
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29KINDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2023/00Use of polyalkenes or derivatives thereof as moulding material
    • B29K2023/10Polymers of propylene
    • B29K2023/12PP, i.e. polypropylene
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29KINDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2033/00Use of polymers of unsaturated acids or derivatives thereof as moulding material
    • B29K2033/04Polymers of esters
    • B29K2033/12Polymers of methacrylic acid esters, e.g. PMMA, i.e. polymethylmethacrylate
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29KINDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2101/00Use of unspecified macromolecular compounds as moulding material
    • B29K2101/12Thermoplastic materials
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2023/00Tubular articles
    • B29L2023/003Tubular articles having irregular or rough surfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2023/00Tubular articles
    • B29L2023/22Tubes or pipes, i.e. rigid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00Other particular articles
    • B29L2031/712Containers; Packaging elements or accessories, Packages

Abstract

A cartridge for an IOL delivery system that has a straight thinned walled distal nozzle. The transition region between the tapered folding portion of the cartridge and the nozzle contain reinforcing gussets to help prevent splitting of the cartridge. Flow leaders in the nozzle direct the flow of material during molding at the 12:00 o'clock position, positioning the weld line of the flow front at the 6:00 o'clock position.

Description

Re; 3161 US

LENS DELIVERY SYSTEM CARTRIDGE
AND METHOD OF MANUFACTURE

This invention relates to intraocular lenses (IOLs) and more particularly to cartridges for use with devices use to inject IOLs into an eye.

Background of the Invention The human eye in its simplest terms functions to provide vision by transmitting and refracting light through a clear outer portion called the cornea, and further focusing the image by way of the lens onto the retina at the back of the eye. The quality of the focused image depends on many factors including the size, shape and length of the eye, and the shape and transparency of the cornea and lens.
When trauma, age or disease cause the lens to become less transparent, vision deteriorates because of the diminished light which can be transmitted to the retina. This deficiency in the lens of the eye is medically known as a cataract. The treatment for this condition is surgical removal of the lens and implantation of an artificial lens or IOL.
While early IOLs were made from hard plastic, such as polymethylmethacrylate (PMMA), soft, foldable IOLs made from silicone, soft acrylics and hydrogels have become increasingly popular because of the ability to fold or roll these soft lenses and insert them through a smaller incision. Several methods of rolling or folding the lenses are used. One popular method is an injector cartridge that folds the lenses and provides a relatively small diameter lumen through which the lens may be pushed into the eye, usually by a soft tip plunger. The most commonly used injector cartridge design is illustrated in U.S. Patent No. 4,681,102 (Bartell), and includes a split, longitudinally hinged cartridge. Similar designs are illustrated in U.S. Patent Nos.
5,494,484 and 5,499,987 (Feingold) and 5,616,148 and 5,620,450 (Eagles, et al.). In an attempt to avoid the claims of U.S. Patent No. 4,681,102, several solid cartridges have been investigated, see for example U.S. Patent No. 5,275,604 (Rheinish, et al.) and 5,653,715 (Reich, et al.).
These prior art devices were intended to inject an IOL into the posterior chamber of an aphakic eye through a relatively large (approximately 3.0 mm or larger) incision.
Surgical techniques and IOLs have been developed that allow the entire surgical procedure to be performed through much smaller incisions, 2.4 mm and smaller.
Such small incisions require that the IOL be compressed very tightly, and that the nozzle used Re: 3161 US

on the injection cartridge have very thin walls. The combination of a tightly compressed lens traveling through a very thin walled nozzle often results in the nozzle splitting during use.
Accordingly, a need continues to exist for an intraocular lens injection cartridge s capable of injection an IOL through a relatively small incision.

Brief Summary of the Invention The present invention improves upon prior art by providing a cartridge for an IOL
delivery system that has a straight, thinned walled distal nozzle. The transition region between the tapered folding portion of the cartridge and the nozzle contains reinforcing gussets to help prevent splitting of the cartridge. Flow leaders in the nozzle direct the flow of material during molding at the 12:00 o'clock position, positioning the weld line of the flow front at the 6:00 o'clock position.
It is accordingly an objective of the present invention to provide a cartridge for a lens delivery system that has a straight, thinned walled distal nozzle.
It is a further objective of the present invention to provide a cartridge for a lens delivery system that contains reinforcing gussets to help prevent splitting of the cartridge.
Other objectives, features and advantages of the present invention will become apparent with reference to the drawings, and the following description of the drawings and claims.

Brief Description of the Drawings FIG. 1 is an enlarged top perspective view of the lens delivery system cartridge of the present invention.
FIG. 2 is an enlarged top perspective view of the distal nozzle of the lens delivery system cartridge of the present invention.
FIG. 3 is an enlarged side elevational view of the distal nozzle of the lens delivery system cartridge of the present invention.

~ ~.
Re: 3161 US

Detailed Description of the Preferred Embodiments As best seen in FIGS. 1-3, lens cartridge 10 of the present invention generally includes body 12 and nozzle 14. Cartridge 10 can be molded from any suitable thermoplastic, such as polypropylene, and the thermoplastic may contain a lubricity enhancing agent such as those disclosed in U.S. Pat. No. 5,716,364, the entire contents of which are incorporated herein by reference. Nozzle 14 may be integrally formed with body 12. Nozzle 14 has a tapered portion 16 and a straight portion 18.
Straight portion 18 has very thin walls, on the order and between 0.07 mm and 0.17 mm thick and preferably is tubular and of substantially constant round, oval or elliptical cross-section, with a cross-sectional area of between around 1.0 mm2 to around 2.6 mm2.
Straight portion 18 is preferably on the order of 3 mm to 5 mm long so as to allow cartridge 10 to deliver IOL 24 inside the capsular bag without tapered portion 16 entering the incision.
Such a construction does not enlarge the incision during IOL insertion.
Transition area between tapered portion 16 and straight portion 18 contain reinforcing gusset 22.
Reinforcing gusset 22 helps prevent splitting of nozzle 14 at transition area 20.
Located on the proximal side of transition area 20, at the distal end of tapered portion 16 are raised flow leaders 26. Flow leaders 26 help direct the flow of material 20 during injection molding of cartridge 10 to 12:00 o'clock position 28, then downwardly around straight portion 18, causing the weld line to form at 6:00 o'clock position 30. The inventors have surprisingly discovered that maximum stress in straight portion 18 occurs around 12:00 o'clock position 28, while minimum stress in straight portion 18 occurs around 6:00 o'clock position 30. Directing the weld line of the material flow to 6:00 o'clock position 30 places the weakest position of straight portion 18 at the location of minimal stress, thereby helping to reduce splitting of straight portion 18 during IOL
injection.
While certain embodiments of the present invention have been described above, these descriptions are given for purposes of illustration and explanation.
Variations, changes, modifications and departures from the systems and methods disclosed above may be adopted without departure from the scope or spirit of the present invention.

Claims (3)

We claim:
1. An intraocular lens delivery system cartridge, comprising:
a) a body, b) a tubular nozzle connected to the body and projecting distally from the body, the nozzle having a proximal tapered portion and a distal straight portion;
and c) a transition area between the tapered portion and the straight portion of the nozzle, the transition area having a gusset.
2. The cartridge of claim 1 wherein the tapered portion further comprises a plurality of flow leaders.
3. A method of manufacturing an intraocular lens delivery system cartridge, comprising the steps of:
a) forming a body; and b) forming a tubular nozzle having a proximal tapered portion and a distal straight portion, the nozzle being connected to the body and projecting distally from the body;
wherein the straight portion is formed so as to place the weakest portion of the straight portion at the location of minimal stress in the straight portion.
CA2623752A 2007-04-11 2008-02-29 Lens delivery system cartridge and method of manufacture Expired - Fee Related CA2623752C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/734,084 US20080255577A1 (en) 2007-04-11 2007-04-11 Lens Delivery System Cartridge and Method of Manufacture
US11/734,084 2007-04-11

Publications (2)

Publication Number Publication Date
CA2623752A1 CA2623752A1 (en) 2008-10-11
CA2623752C true CA2623752C (en) 2011-01-04

Family

ID=39358359

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2623752A Expired - Fee Related CA2623752C (en) 2007-04-11 2008-02-29 Lens delivery system cartridge and method of manufacture

Country Status (22)

Country Link
US (1) US20080255577A1 (en)
EP (1) EP1980219B1 (en)
JP (1) JP4546550B2 (en)
KR (1) KR100964765B1 (en)
CN (1) CN101283934B (en)
AR (1) AR067214A1 (en)
AT (1) ATE441382T1 (en)
AU (1) AU2008201269B2 (en)
BR (1) BRPI0800986B8 (en)
CA (1) CA2623752C (en)
CY (1) CY1109635T1 (en)
DE (1) DE602008000131D1 (en)
DK (1) DK1980219T3 (en)
ES (1) ES2332674T3 (en)
HR (1) HRP20090637T1 (en)
IL (1) IL189870A (en)
MX (1) MX2008004103A (en)
PL (1) PL1980219T3 (en)
PT (1) PT1980219E (en)
RU (1) RU2380071C2 (en)
SI (1) SI1980219T1 (en)
TW (1) TWI374732B (en)

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ES2332674T3 (en) 2010-02-10
RU2380071C2 (en) 2010-01-27
EP1980219B1 (en) 2009-09-02
TW200843711A (en) 2008-11-16
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US20080255577A1 (en) 2008-10-16
EP1980219A1 (en) 2008-10-15
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BRPI0800986A2 (en) 2008-11-25
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AU2008201269B2 (en) 2010-02-11
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CA2623752A1 (en) 2008-10-11
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IL189870A0 (en) 2008-12-29
CY1109635T1 (en) 2014-08-13

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