CA2649867A1 - Method for compensating for pressure differences across valves in cassette type iv pump - Google Patents

Method for compensating for pressure differences across valves in cassette type iv pump Download PDF

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Publication number
CA2649867A1
CA2649867A1 CA002649867A CA2649867A CA2649867A1 CA 2649867 A1 CA2649867 A1 CA 2649867A1 CA 002649867 A CA002649867 A CA 002649867A CA 2649867 A CA2649867 A CA 2649867A CA 2649867 A1 CA2649867 A1 CA 2649867A1
Authority
CA
Canada
Prior art keywords
fluid
pump
outlet
correction factor
inlet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002649867A
Other languages
French (fr)
Other versions
CA2649867C (en
Inventor
Peter A. Holst
David A. Krajewski
Rudolph J. Maske
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hospira Inc
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CA2649867A1 publication Critical patent/CA2649867A1/en
Application granted granted Critical
Publication of CA2649867C publication Critical patent/CA2649867C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14224—Diaphragm type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16809—Flow controllers by repeated filling and emptying of an intermediate volume
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D16/00—Control of fluid pressure
    • G05D16/20—Control of fluid pressure characterised by the use of electric means
    • G05D16/2006—Control of fluid pressure characterised by the use of electric means with direct action of electric energy on controlling means
    • G05D16/2013—Control of fluid pressure characterised by the use of electric means with direct action of electric energy on controlling means using throttling means as controlling means
    • G05D16/2026—Control of fluid pressure characterised by the use of electric means with direct action of electric energy on controlling means using throttling means as controlling means with a plurality of throttling means
    • G05D16/2046—Control of fluid pressure characterised by the use of electric means with direct action of electric energy on controlling means using throttling means as controlling means with a plurality of throttling means the plurality of throttling means being arranged for the control of a single pressure from a plurality of converging pressures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3355—Controlling downstream pump pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16827—Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
    • A61M5/365—Air detectors

Abstract

A pump used to infuse a fluid into a patient is controlled in accordance with an algorithm that enables a microprocessor (17) to monitor and adjust each pump cycle to compensate for a differential pressure between the pump's inlet and outlet.
The algorithm defines a fluid delivery protocol that is applied in controlling the operation of the pump to achieve a desired rate, volume, and timing of the fluid infusion. Fluid is delivered by the pump when a plunger (42) compresses an elastomeric membrane (29) overlying a fluid chamber (30). Due to the small volume of the chamber, an incremental change in the plunger position before the delivery stroke produces a significant change in the delivery pressure. At the beginning of a pump cycle, the microprocessor determines the differential pressure between the inlet and outlet of the pump, and adjusts the plunger position before the delivery stroke to compensate for the differential pressure. A
retraction of the plunger from the home position decreases the delivery pressure of the fluid, and an advancement of the plunger increases it. After the position of the plunger is adjusted to compensate for the differential pressure, the pump cycle proceeds.
Following the plunger stroke, the outlet pressure is used to determine the actual volume of fluid delivered. The duration of the plunger stroke in the next pump cycle is adjusted to compensate for any volume delivery error produced by the differential pressure compensation.

Claims (8)

1. A system for maintaining a desired delivery rate of a fluid flow through an intravenous line, comprising:
(a) a pump chassis;
(b) a pump in fluid communication with the intravenous line and mountable within the pump chassis to receive a driving force from a driven member, said pump including an inlet port, an outlet port, an elastomeric membrane overlying a chamber comprising a portion of a fluid path extending between the inlet port and outlet port, said driven member exerting a force on the elastomeric membrane that displaces the fluid from the chamber and into the intravenous line;
(c) an inlet pressure sensor that produces an inlet pressure signal indicative of an inlet pressure upstream of the chamber;
(d) an outlet pressure sensor that produces an outlet pressure signal indicative of an outlet pressure downstream of the chamber, and (e) a controller that is electrically coupled to the inlet pressure sensor and the outlet pressure sensor to receive the inlet and the outlet pressure signals, said controller employing the inlet pressure signal and the outlet pressure signal to determine a first correction factor to be applied to an initial position of the driven member, said first correction factor being expressed as a change in a position of the driven member relative to the chamber.
2. The system of Claim 1, wherein when the first correction factor requires the driven member to be advanced toward the chamber, a pressure at which the fluid is released from the outlet port is increased; and wherein when the first correction factor requires the driven member to be retracted away from the chamber, the pressure at which the fluid is released from the outlet port is decreased.
3. The system of Claim 1, wherein the first correction factor is applied to change the position the driven member relative to the chamber at the beginning of each pump cycle.
4. The system of any one of Claims 1 to 3, wherein the controller monitors the outlet pressure signal to determine a pressure spike associated with the release of fluid from the outlet port and determines a second correction factor to be applied to the inlet pressure signal to correct for any calibration difference between the inlet port and the outlet port pressure sensors.
5. The system of any one of Claims 1 to 3, wherein the controller uses the inlet pressure signal and the outlet pressure signal to determine an actual volume of fluid delivered during each pump cycle, and determines a third correction factor to be applied to a duration of a delivery stroke in the next pump cycle, to compensate for a difference between the actual volume of the fluid delivered and a target volume.
6. The system of any one of Claims 1 to 3, wherein the controller further comprises a processor and a memory, and the memory stores a plurality machine instructions that cause the processor to perform a plurality of logical steps when the machine instructions are executed by the processor, said logical steps including:
(a) sampling the inlet pressure signal produced by the inlet pressure sensor, and the outlet pressure signal produced by the outlet pressure sensor during each pump cycle to determine said first correction factor, and applying the first correction factor during the current pump cycle;
(b) sampling the inlet pressure signal produced by the inlet pressure sensor and the outlet pressure signal produced by the outlet pressure sensor as the fluid is released from the outlet port, to determine a second correction factor, said second correction factor correcting for a calibration difference between said inlet and outlet pressure sensors, and applying the second correction factor to the inlet pressure signal during the next pump cycle, and (c) sampling the inlet pressure signal produced by the inlet pressure sensor and the outlet pressure signal produced by the outlet pressure sensor after the fluid is released from the outlet port to determine a third correction factor, said third correction factor adjusting a duration of a pump delivery stroke, and applying the third correction factor during the next pump cycle.
7. The system of any one of Claims 1 to 6, wherein a plurality of samples are averaged to minimize an effect of variations in pressure, individual samples being taken during one of a predefined interval of time and a duration of a step of a prime mover that is providing the driving force.
8. A system for maintaining a desired delivery rate of a fluid flow through an intravenous line, comprising:

(a) a pump chassis;
(b) a pump in fluid communication with the intravenous line and mountable within the pump chassis to receive a driving force from a driven member, said pump including an inlet port, an outlet port, an elastomeric membrane overlying a chamber comprising a portion of a fluid path extending between the inlet port and outlet port, said driven member exerting a force on the elastomeric membrane that displaces the fluid from the chamber and into the intravenous line;
(c) at least one pressure sensor that produces a pressure signal indicative of a pressure in the chamber;
(d) a controller that is electrically coupled to the at least one pressure sensor to receive pressure signals at various parts of a pump cycle, said controller employing the pressure signals to determine a first correction factor to be applied to an initial position of the driven member, said first correction factor being expressed as a change in a position of the driven member relative to the chamber.
CA2649867A 1999-12-17 2000-12-15 Method for compensating for pressure differences across valves in cassette type iv pump Expired - Lifetime CA2649867C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/464,812 US6497680B1 (en) 1999-12-17 1999-12-17 Method for compensating for pressure differences across valves in cassette type IV pump
US09/464,812 1999-12-17
CA002393337A CA2393337C (en) 1999-12-17 2000-12-15 Method for compensating for pressure differences across valves in cassette type iv pump

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002393337A Division CA2393337C (en) 1999-12-17 2000-12-15 Method for compensating for pressure differences across valves in cassette type iv pump

Publications (2)

Publication Number Publication Date
CA2649867A1 true CA2649867A1 (en) 2001-06-21
CA2649867C CA2649867C (en) 2010-06-01

Family

ID=23845331

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2649867A Expired - Lifetime CA2649867C (en) 1999-12-17 2000-12-15 Method for compensating for pressure differences across valves in cassette type iv pump
CA002393337A Expired - Fee Related CA2393337C (en) 1999-12-17 2000-12-15 Method for compensating for pressure differences across valves in cassette type iv pump

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002393337A Expired - Fee Related CA2393337C (en) 1999-12-17 2000-12-15 Method for compensating for pressure differences across valves in cassette type iv pump

Country Status (9)

Country Link
US (4) US6497680B1 (en)
EP (2) EP1611909B1 (en)
JP (1) JP4673535B2 (en)
AT (2) ATE309013T1 (en)
AU (1) AU778557B2 (en)
CA (2) CA2649867C (en)
DE (2) DE60042530D1 (en)
ES (2) ES2327750T3 (en)
WO (1) WO2001043798A1 (en)

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US9915274B2 (en) 2013-03-15 2018-03-13 Novartis Ag Acoustic pumps and systems
US9962288B2 (en) 2013-03-07 2018-05-08 Novartis Ag Active acoustic streaming in hand piece for occlusion surge mitigation
US10182940B2 (en) 2012-12-11 2019-01-22 Novartis Ag Phacoemulsification hand piece with integrated aspiration and irrigation pump

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