CA2666694A1 - Electrically actuated annelid - Google Patents
Electrically actuated annelid Download PDFInfo
- Publication number
- CA2666694A1 CA2666694A1 CA002666694A CA2666694A CA2666694A1 CA 2666694 A1 CA2666694 A1 CA 2666694A1 CA 002666694 A CA002666694 A CA 002666694A CA 2666694 A CA2666694 A CA 2666694A CA 2666694 A1 CA2666694 A1 CA 2666694A1
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- Prior art keywords
- segment
- electro
- active polymer
- segments
- extensor
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0116—Steering means as part of the catheter or advancing means; Markers for positioning self-propelled, e.g. autonomous robots
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0058—Catheters; Hollow probes characterised by structural features having an electroactive polymer material, e.g. for steering purposes, for control of flexibility, for locking, for opening or closing
Abstract
An apparatus for delivery (100) through a vessel (116) including an extensor segment (104) and first (102) and second (106) anchor segments positioned on either side of the extensor segment, wherein each segment has associated with it an individually-addressable electro-active polymer.
Description
ELECTRICALLY ACTUATED ANNELID
FIELD OF DISCLOSURE
This application relates:to electro-active polymers:for medical applications.
BACKGROUND
Catheter systems have.been used for internal delivery of treatment devices and drugs. Such systems have been uscd.with miriimally invasive surgical procedures, such as key-hole surgery.
Current catheter systeins often use guide-wires to.position the treatment devices and drugs within-the body. Effective use of current systems requires sorile skill to maneuver the guide wire with accuracy and precision.
Electro-active polymers can be used in devices that can exert forees or execute movements upon external stimulation, e.g., electrical current. Electrical current causes relative volume change o.fthe electro-active polymer resulting in movements such as bending, expanding or contracting. Some are made of a bi-layer of a conducting polymer and a carrier substrate, e.g., a:metal or:a polymer. These devices:can have lateral dimensions ranging from micrometers to centimeters and layer thickness in the range: of nanometers to millimeters: Additional information concerning electro-active polymers and their application are described in International Publication Nos. WO
96/28841, filed August 3, 1996;. WO 00/78222, filed June 18,2000; WO 03/39859, filed June 11, 2002;
and WO 04/92050, filed April 8, 2004, and U.S. Patent Nos. 6;103,399, filed December 30, 1997 and issued August 25, 2000; and 6,933;659, filed.May 5,.2004 and issued August 23, 2005, all of'which are incorporated herein by reference.
SUMMARY
In one aspect, an apparatus for delivery through a vessel includes an extensor segment, and first and second anchor segments positioned on either side of the extensor segment, wherein each segment has associated.with it an individually-addressable electro-active polymer.
Tmplementations can include one or more of the following. At least one:of the segments is configured to carry an agent. The apparatus includes a power source coupled l to provide.electrical current to actuate the electro-active polymer of each segment. The apparatus includes a controller configured to direct a control signal to cause actuation of the clectro-active polymer associated with a.segment. The electro-active polymer includes a polypyrrole polymer. The electro.-active polymer associated with a segment includes an individually-addressable bulk-actuating electro-active polymer.
The electro-active polymer associated with a segment.includes an individually-addressable.
length-actuating elcctro-active polymer. A segment includes a pair of electro-active polymer fingers conf gured to form a fork in.response to actuation. A. segment includea a series of sub-segments, wherein each sub-segment has associated with it an individually-addressable electro-active polymer. The extensor segment includes plural ligaments, wherein each ligament has associated with it an individually=addressable electro-active polymer. A segment includes a pair of.individually-addressable electro-activesides configured to change the orientation of the segment in response to actuation.
The extensor segment includes plural individually addressable ligaments wound in a helix. At least.one segment includes a separately actuable agent-holding electro-active polymer 'configured to secure the agent in response to actuation. At least one of the segments includes a radio=opaque material. The apparatus includes an;external power source electrically coupled to the segments. The electrical coupling can be an inductive coupling. T'he apparatus includes a battery electrically coupled to the segments.
In another aspect,_a method of propelling an apparatus through a vessel includes securing a first anchor segment within the vessel, elongating an extensor segment, securing a second anchor. segment within the.vessel, releasing the first anchor sewent from the vessel, and contracting the extensor segment.
Implementations can include one or more of the following. The method includes steering the apparatus within the vessel. The method includes extending a first side of an anchor segrnent while contracting a second side of the anchor'sewent. The method includes controlling the,speed of propulsion. The method includes controlling the direction of propulsion. 'I'he method includes affixing an agent to a segnent of the delivery apparatus.
In yet another aspect a synthetic annelid: includes a plurality of connected segments, eachsegment being actuable independently of the other segments.
FIELD OF DISCLOSURE
This application relates:to electro-active polymers:for medical applications.
BACKGROUND
Catheter systems have.been used for internal delivery of treatment devices and drugs. Such systems have been uscd.with miriimally invasive surgical procedures, such as key-hole surgery.
Current catheter systeins often use guide-wires to.position the treatment devices and drugs within-the body. Effective use of current systems requires sorile skill to maneuver the guide wire with accuracy and precision.
Electro-active polymers can be used in devices that can exert forees or execute movements upon external stimulation, e.g., electrical current. Electrical current causes relative volume change o.fthe electro-active polymer resulting in movements such as bending, expanding or contracting. Some are made of a bi-layer of a conducting polymer and a carrier substrate, e.g., a:metal or:a polymer. These devices:can have lateral dimensions ranging from micrometers to centimeters and layer thickness in the range: of nanometers to millimeters: Additional information concerning electro-active polymers and their application are described in International Publication Nos. WO
96/28841, filed August 3, 1996;. WO 00/78222, filed June 18,2000; WO 03/39859, filed June 11, 2002;
and WO 04/92050, filed April 8, 2004, and U.S. Patent Nos. 6;103,399, filed December 30, 1997 and issued August 25, 2000; and 6,933;659, filed.May 5,.2004 and issued August 23, 2005, all of'which are incorporated herein by reference.
SUMMARY
In one aspect, an apparatus for delivery through a vessel includes an extensor segment, and first and second anchor segments positioned on either side of the extensor segment, wherein each segment has associated.with it an individually-addressable electro-active polymer.
Tmplementations can include one or more of the following. At least one:of the segments is configured to carry an agent. The apparatus includes a power source coupled l to provide.electrical current to actuate the electro-active polymer of each segment. The apparatus includes a controller configured to direct a control signal to cause actuation of the clectro-active polymer associated with a.segment. The electro-active polymer includes a polypyrrole polymer. The electro.-active polymer associated with a segment includes an individually-addressable bulk-actuating electro-active polymer.
The electro-active polymer associated with a segment.includes an individually-addressable.
length-actuating elcctro-active polymer. A segment includes a pair of electro-active polymer fingers conf gured to form a fork in.response to actuation. A. segment includea a series of sub-segments, wherein each sub-segment has associated with it an individually-addressable electro-active polymer. The extensor segment includes plural ligaments, wherein each ligament has associated with it an individually=addressable electro-active polymer. A segment includes a pair of.individually-addressable electro-activesides configured to change the orientation of the segment in response to actuation.
The extensor segment includes plural individually addressable ligaments wound in a helix. At least.one segment includes a separately actuable agent-holding electro-active polymer 'configured to secure the agent in response to actuation. At least one of the segments includes a radio=opaque material. The apparatus includes an;external power source electrically coupled to the segments. The electrical coupling can be an inductive coupling. T'he apparatus includes a battery electrically coupled to the segments.
In another aspect,_a method of propelling an apparatus through a vessel includes securing a first anchor segment within the vessel, elongating an extensor segment, securing a second anchor. segment within the.vessel, releasing the first anchor sewent from the vessel, and contracting the extensor segment.
Implementations can include one or more of the following. The method includes steering the apparatus within the vessel. The method includes extending a first side of an anchor segrnent while contracting a second side of the anchor'sewent. The method includes controlling the,speed of propulsion. The method includes controlling the direction of propulsion. 'I'he method includes affixing an agent to a segnent of the delivery apparatus.
In yet another aspect a synthetic annelid: includes a plurality of connected segments, eachsegment being actuable independently of the other segments.
Implementations can include a segment having associated.with it an electro-active polymer.
DESCRIPTION OF DRAWINGS
FIG. 1 shows a synthetic annelid and control, system.
FIGS. 2-6 show a movement of the annelid.
FIGS. 7-8;show anchoring mechanisms for the annelid.
FIG. 9 shows cross-sectional views of constructions of an anchor segment of the annelid.
FIGS. 10-11 show constructions of an extensor segment.ofthe annelid.
FIGS. 12-14 show an agent affixed.to the.annelid.
DETAIL,ED DESCRIPTION
l.n. the example of FIG. 1,. a synthetic aiuielid 100 has first and second anchor segnents 102, 1:06 on either side of a center extensor segnent 104: Together, the anchor segments. 102, 106 and the extensor segment 104: cooperate to allow the annelid 100 to crawl through a network of vessels. In.some implementations, the annelid 100 delivers agents into a.body to a position that might otherwise be unreachable, In other implementations, the device contairis radio-opaque niaterials to allow the user to visualize the annelid as it traverses:the network.
As used in this description,, vessels include arteries or veins, as; well as:pipes and tubes generally. Agents refer to drugs or medical devices such as stents, balloons, gafts, or filters, as well as non-medical tools gencrally: Bodies;include the human body or animal bodies, as well as physical.objects generally.
Incorporated into the anchor segment"s 102, 106 and the extensor segment 104 is an electro-active polymer (EAP), for example; ;a polypyrrole polymer.
The user applies an electrical current to the EA.i's to activate or "actuate".the.
segments 102,.104, 106 to manipulate the mass, size, shape or orientation of the segments from a preset condition, thereby causing the annelid 1.00 to crawl through a vessel, as discussed in more detail in connection with FIGS. 2-6. The user selectively actuates the .EAPs with an external joystick 108 to electronically:.ebntrol both the:direction and speed of the annelid 100 as it crawls:through the vessel. The joystick 108 interacts with a controller 109 that selectively directs electrical current to the segnnents 102, 104, 106, thereby actuating the segments to cause movement. For example, the user taps the joystick 108 in the proximal or distal direction to cause.the annelid ,100 to slowly crawl proximally or distally, respectively. The user pushes.the joystick 108 in:the proximal or distal direction to cause the annelid. 100 to crawl more quickly proximally or distally, respectively.. The controller' 1.09 can be disposed 'either external to thi;.annelid or integrated in the annelid.
In some implementations, the. controller 109 directs the electrical current to the segments 102, 104, 106 via electrical wires 110 that extend through a micro-catheter 114 between the segments 102, 104, 106 and a power source 112. In other implementations, tlie power source is an external power source 112. The externai power source:112 can be.
integrated with the joystick 108 so that currentis transmitted to the annelid 100 on a wire.
Alternatively, the external power source can be an induction power source that induces current in the annelid 100. This induces 'a current in the annelid.100 that either actuates the. segments, or charges a batterythat provides power.for actuating the segnents. The annelid 100 can'therefore be powered without electrical wires 110.
In yet other implementations, the power source is a battery. The. use of a battery 113 as a power source also eliminates the need for having, a length of electrical wire 110 extending all the way from the annelid 100 through the micro-catheter 114.
Some implementations feature both a battery powered system and an extenrnal power supply to serve as a backup power system.
The user selectively actuates the segments 102, 104, 106 to cause the aimelid to crawl through the network of vessels. In the example of FIGS. 1-6, after having positioned the annelid 100 within the vessel 118 (FIC'~ 1), the user actuates the frst.
anchor selynent 102 (FIG.:2). The first anchor segment 102, when actuated, enlarges its diameter. This places the adjacent'area of the vessel under tensile or 'compressive load and secures the annelid 100. The user then. actuates the extensor segment 104, as shown in FIG. 3. The extensor segnent 104, when actuated, elongates the annelid 100.
The user then actuates the second anchor segment 106, as shown in F.ICI 4. Like.the first anchor seginent.102, the second anchor segment 106, when actuated, enlarges its diameter, 4' therc;by placing the adjacent area of the vessel under atensile or compressiveload and securing the annelid 100. The user then dcactuates the first anchor segment*
102 (FIG. 5) to deanchor it, and deactuates the extensor segment 104, as shown in FIG. 5.
As a result, as shown in FIC~ 6, the, device is displaced by a distance that depends on the extent to which the extensor segment 104. was elongated. By dcactuating the. second anchor segment 106. and then repeating the actu.ating sequence shown inFIGS. 2-6, the user causes the annelid 100 to crawl proximally. By reversing, the steps of FIGS. 2-6, the user can also cause the annelid 100 to crawl distally. This manner of causing the annelid to traverse the network of vessels may eliminate the need.for guide wires or guide catheters in applications where they are traditionally used.
In some implementations, the. segcnents 102, 104, 106. each have a series of individually addressable.actuating sub-segments to allow the:annelid 100 to crawl through the vessel on a finely controlled basi"s. These implemeiitations permit the user to cause.minute movements.of one sub-segment.of the annelid 100 without affecting other sub-segments of the annelid:
In an embodiment shown in FIG. 7, the user actuates opposed first and. second sides 120, 122 of the anchor segment 106 to contract the first side 120 and elongate the second side 122 of the anchor segment 106. As a result, the user changes the.
orientation of the anchor segment, thereby essentially steering the annelid 100. In addition, in this implementation, by changing the orientation of the anchor segments 102, 106, the user can direct'the annelid 100 throul;h a particular branch of a fork (i.e. an intersection of paths) in the vessel.
In another embodiment shown in FIG. 8, the anchor segments .102, 106 feature individually actuable fingers 124, 126. Wlien actuated, the fingers 124; 126 change orientation (as. described above) to swing out and form a fork-like structure that -secures the annelid 100 to the vessel wall.
The anchor segments 102;.106 can, but need not have identical structural cross-sections. While the anehor segments.102, 106 can be of any cross-section, FIG.
9 shows possible cross-sections, including circular cross-sections 128 and triangular cross-sections 130. In either case, as~shown in FIG. 9, the cross-sections can. be solid 132, or with one hole 134 or with many holes 136. In some implementations, to facilitate blood flow through the vessel, the cross-section has one or more holes.
In the implementations. described thus far, the extensor segment 104 is a-single straight tube connecting theanchor segments 102, 106. In other implementations, as shown in FIG 10, the extensor segment 104 includes.multiple ligaments 138, 140, 142, each of which is an independently actuable extensor. The multiple ligament implernentation of FIG. 10 enables the annelid 100 to conform closely to the vessel anatomy. For example, if one were to elongate some, but not all, of:the ligaments, the annelid 100 would curve. This is useful for crawling through. a..curved vessel. In some implementatioris, the individual ligaments 138, 140, 142 each have a series of individually actuable extensor sub-segments to allow the user to better control movement of the annelid 100 within the vessel. In FIG I 1; the extensor segment 104 features one or more ligaments wound in a helix 144. The resulting helix 144 also allows the user to better control movement of the annelid 100 within the vessel. The helix 144 causes the an.nelid 100 to twist as it moves within the vessel:
In the example of FIGS. 1,2-13, an.agent 146 is affixed to the annelid 100 for delivery to a particular location. The. agent is affixed either along the:
extensor segment 104, or to one or both anchor segnents 102, 106: One way to engage the.agent 146 is to insert the agent into a.hole 148 in the.anchor segrnent 102, 106. The hole 148 includes a separately actuable agent-holding EAR When actuated, as shown in FIG. 14, the anchor segment clainps down (150) on the agent 146. The agent 146 can then be delivered through the vessel.to the desired location within the body. When the annelid 100 delivers the agent 146 to the desired location, the anchor segment 102,106 is deactuated, thereby relaxing its grip on the agent 146 and causing the agent's release into the vessel.
In some implementations, the annelid 100 can be used.in conjunction with other annelids 100. For example, two or more annelids can be arranged in sequence.
Other embodiments are within the-scope:of the following claims.
What is claimed is:
DESCRIPTION OF DRAWINGS
FIG. 1 shows a synthetic annelid and control, system.
FIGS. 2-6 show a movement of the annelid.
FIGS. 7-8;show anchoring mechanisms for the annelid.
FIG. 9 shows cross-sectional views of constructions of an anchor segment of the annelid.
FIGS. 10-11 show constructions of an extensor segment.ofthe annelid.
FIGS. 12-14 show an agent affixed.to the.annelid.
DETAIL,ED DESCRIPTION
l.n. the example of FIG. 1,. a synthetic aiuielid 100 has first and second anchor segnents 102, 1:06 on either side of a center extensor segnent 104: Together, the anchor segments. 102, 106 and the extensor segment 104: cooperate to allow the annelid 100 to crawl through a network of vessels. In.some implementations, the annelid 100 delivers agents into a.body to a position that might otherwise be unreachable, In other implementations, the device contairis radio-opaque niaterials to allow the user to visualize the annelid as it traverses:the network.
As used in this description,, vessels include arteries or veins, as; well as:pipes and tubes generally. Agents refer to drugs or medical devices such as stents, balloons, gafts, or filters, as well as non-medical tools gencrally: Bodies;include the human body or animal bodies, as well as physical.objects generally.
Incorporated into the anchor segment"s 102, 106 and the extensor segment 104 is an electro-active polymer (EAP), for example; ;a polypyrrole polymer.
The user applies an electrical current to the EA.i's to activate or "actuate".the.
segments 102,.104, 106 to manipulate the mass, size, shape or orientation of the segments from a preset condition, thereby causing the annelid 1.00 to crawl through a vessel, as discussed in more detail in connection with FIGS. 2-6. The user selectively actuates the .EAPs with an external joystick 108 to electronically:.ebntrol both the:direction and speed of the annelid 100 as it crawls:through the vessel. The joystick 108 interacts with a controller 109 that selectively directs electrical current to the segnnents 102, 104, 106, thereby actuating the segments to cause movement. For example, the user taps the joystick 108 in the proximal or distal direction to cause.the annelid ,100 to slowly crawl proximally or distally, respectively. The user pushes.the joystick 108 in:the proximal or distal direction to cause the annelid. 100 to crawl more quickly proximally or distally, respectively.. The controller' 1.09 can be disposed 'either external to thi;.annelid or integrated in the annelid.
In some implementations, the. controller 109 directs the electrical current to the segments 102, 104, 106 via electrical wires 110 that extend through a micro-catheter 114 between the segments 102, 104, 106 and a power source 112. In other implementations, tlie power source is an external power source 112. The externai power source:112 can be.
integrated with the joystick 108 so that currentis transmitted to the annelid 100 on a wire.
Alternatively, the external power source can be an induction power source that induces current in the annelid 100. This induces 'a current in the annelid.100 that either actuates the. segments, or charges a batterythat provides power.for actuating the segnents. The annelid 100 can'therefore be powered without electrical wires 110.
In yet other implementations, the power source is a battery. The. use of a battery 113 as a power source also eliminates the need for having, a length of electrical wire 110 extending all the way from the annelid 100 through the micro-catheter 114.
Some implementations feature both a battery powered system and an extenrnal power supply to serve as a backup power system.
The user selectively actuates the segments 102, 104, 106 to cause the aimelid to crawl through the network of vessels. In the example of FIGS. 1-6, after having positioned the annelid 100 within the vessel 118 (FIC'~ 1), the user actuates the frst.
anchor selynent 102 (FIG.:2). The first anchor segment 102, when actuated, enlarges its diameter. This places the adjacent'area of the vessel under tensile or 'compressive load and secures the annelid 100. The user then. actuates the extensor segment 104, as shown in FIG. 3. The extensor segnent 104, when actuated, elongates the annelid 100.
The user then actuates the second anchor segment 106, as shown in F.ICI 4. Like.the first anchor seginent.102, the second anchor segment 106, when actuated, enlarges its diameter, 4' therc;by placing the adjacent area of the vessel under atensile or compressiveload and securing the annelid 100. The user then dcactuates the first anchor segment*
102 (FIG. 5) to deanchor it, and deactuates the extensor segment 104, as shown in FIG. 5.
As a result, as shown in FIC~ 6, the, device is displaced by a distance that depends on the extent to which the extensor segment 104. was elongated. By dcactuating the. second anchor segment 106. and then repeating the actu.ating sequence shown inFIGS. 2-6, the user causes the annelid 100 to crawl proximally. By reversing, the steps of FIGS. 2-6, the user can also cause the annelid 100 to crawl distally. This manner of causing the annelid to traverse the network of vessels may eliminate the need.for guide wires or guide catheters in applications where they are traditionally used.
In some implementations, the. segcnents 102, 104, 106. each have a series of individually addressable.actuating sub-segments to allow the:annelid 100 to crawl through the vessel on a finely controlled basi"s. These implemeiitations permit the user to cause.minute movements.of one sub-segment.of the annelid 100 without affecting other sub-segments of the annelid:
In an embodiment shown in FIG. 7, the user actuates opposed first and. second sides 120, 122 of the anchor segment 106 to contract the first side 120 and elongate the second side 122 of the anchor segment 106. As a result, the user changes the.
orientation of the anchor segment, thereby essentially steering the annelid 100. In addition, in this implementation, by changing the orientation of the anchor segments 102, 106, the user can direct'the annelid 100 throul;h a particular branch of a fork (i.e. an intersection of paths) in the vessel.
In another embodiment shown in FIG. 8, the anchor segments .102, 106 feature individually actuable fingers 124, 126. Wlien actuated, the fingers 124; 126 change orientation (as. described above) to swing out and form a fork-like structure that -secures the annelid 100 to the vessel wall.
The anchor segments 102;.106 can, but need not have identical structural cross-sections. While the anehor segments.102, 106 can be of any cross-section, FIG.
9 shows possible cross-sections, including circular cross-sections 128 and triangular cross-sections 130. In either case, as~shown in FIG. 9, the cross-sections can. be solid 132, or with one hole 134 or with many holes 136. In some implementations, to facilitate blood flow through the vessel, the cross-section has one or more holes.
In the implementations. described thus far, the extensor segment 104 is a-single straight tube connecting theanchor segments 102, 106. In other implementations, as shown in FIG 10, the extensor segment 104 includes.multiple ligaments 138, 140, 142, each of which is an independently actuable extensor. The multiple ligament implernentation of FIG. 10 enables the annelid 100 to conform closely to the vessel anatomy. For example, if one were to elongate some, but not all, of:the ligaments, the annelid 100 would curve. This is useful for crawling through. a..curved vessel. In some implementatioris, the individual ligaments 138, 140, 142 each have a series of individually actuable extensor sub-segments to allow the user to better control movement of the annelid 100 within the vessel. In FIG I 1; the extensor segment 104 features one or more ligaments wound in a helix 144. The resulting helix 144 also allows the user to better control movement of the annelid 100 within the vessel. The helix 144 causes the an.nelid 100 to twist as it moves within the vessel:
In the example of FIGS. 1,2-13, an.agent 146 is affixed to the annelid 100 for delivery to a particular location. The. agent is affixed either along the:
extensor segment 104, or to one or both anchor segnents 102, 106: One way to engage the.agent 146 is to insert the agent into a.hole 148 in the.anchor segrnent 102, 106. The hole 148 includes a separately actuable agent-holding EAR When actuated, as shown in FIG. 14, the anchor segment clainps down (150) on the agent 146. The agent 146 can then be delivered through the vessel.to the desired location within the body. When the annelid 100 delivers the agent 146 to the desired location, the anchor segment 102,106 is deactuated, thereby relaxing its grip on the agent 146 and causing the agent's release into the vessel.
In some implementations, the annelid 100 can be used.in conjunction with other annelids 100. For example, two or more annelids can be arranged in sequence.
Other embodiments are within the-scope:of the following claims.
What is claimed is:
Claims (25)
1. An apparatus for delivery through a vessel, the apparatus comprising:
an extensor segment; and first and second anchor segments positioned on either side of the extensor segment;
wherein each segment has associated with it an individually-addressable electro-active polymer.
an extensor segment; and first and second anchor segments positioned on either side of the extensor segment;
wherein each segment has associated with it an individually-addressable electro-active polymer.
2. The apparatus of claim 1, wherein at least one of the segments is configured to carry an agent.
3. The apparatus of claim 1, further comprising:
a power source coupled to provide electrical current to actuate the electro-active polymer of each segment.
a power source coupled to provide electrical current to actuate the electro-active polymer of each segment.
4. The apparatus of claim 1, further comprising:
a controller configured to direct a control signal to cause actuation of the electro-active polymer associated with a segment.
a controller configured to direct a control signal to cause actuation of the electro-active polymer associated with a segment.
5. The apparatus of claim 1, wherein the electro-active polymer comprises a polypyrrole polymer.
6. The apparatus of claim 1, wherein the electro-active polymer associated with a segment comprises an individually-addressable bulk-actuating electro-active polymer.
7. The apparatus of claim 1, wherein the electro-active polymer associated with a segment comprises an individually-addressable length-actuating electro-active polymer.
8. The apparatus of claim 1, wherein a segment comprises a pair of electro-active polymer fingers configured to form a fork in response to actuation.
9. The apparatus of claim 1, wherein a segment comprises a series of sub-segments, wherein each sub-segment has associated with it an individually-addressable electro-active polymer.
10. The apparatus of claim 1, wherein the extensor segment comprises plural ligaments, wherein each ligament has associated with it an individually-addressable electro-active polymer.
11. The apparatus of claim 1, wherein a segment comprises a pair of individually-addressable electro-active sides configured to change the orientation of the segment in response to actuation.
12. The apparatus of claim 1, wherein the extensor segment comprises plural individually addressable ligaments wound in a helix.
13. The apparatus of claim 1, wherein the at least one segment comprises a separately actuable agent-holding electro-active polymer configured to secure the agent in response to actuation.
14. The apparatus of claim 1, wherein at least one of the segments includes a radio-opaque material.
15. The apparatus of claim 1, further comprising:
an external power source electrically coupled to the segments.
an external power source electrically coupled to the segments.
16. The apparatus of claim 15, wherein the electric coupling comprises an inductive coupling.
17. The apparatus of claim 1, further comprising:
a battery electrically coupled to the segments.
a battery electrically coupled to the segments.
18. A method of propelling an apparatus through a vessel, the method comprising:
securing a first anchor segment within the vessel;
elongating an extensor segment;
securing a second anchor segment within the vessel;
releasing the first anchor segment from the vessel; and contracting the extensor segment.
securing a first anchor segment within the vessel;
elongating an extensor segment;
securing a second anchor segment within the vessel;
releasing the first anchor segment from the vessel; and contracting the extensor segment.
19. The method of claim 18, further comprising:
steering the apparatus within the vessel.
steering the apparatus within the vessel.
20. The method of claim 18, further comprising:
extending a first side of an anchor segment while contracting a second side of the anchor segment.
extending a first side of an anchor segment while contracting a second side of the anchor segment.
21. The method of claim 18, further comprising:
controlling the speed of propulsion.
controlling the speed of propulsion.
22. The method of claim 18, further comprising:
controlling the direction of propulsion.
controlling the direction of propulsion.
23. The method of claim 18, further comprising:
affixing an agent to a segment of the delivery apparatus.
affixing an agent to a segment of the delivery apparatus.
24. A synthetic annelid comprising:
a plurality of connected segments, each segment being actuable independently of the other segments.
a plurality of connected segments, each segment being actuable independently of the other segments.
25. The synthetic annelid of claim 24, wherein a segment has associated with it an electro-active polymer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/506,491 | 2006-08-18 | ||
US11/506,491 US9242073B2 (en) | 2006-08-18 | 2006-08-18 | Electrically actuated annelid |
PCT/US2007/075955 WO2008022168A1 (en) | 2006-08-18 | 2007-08-15 | Electrically actuated annelid |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2666694A1 true CA2666694A1 (en) | 2008-02-21 |
Family
ID=38666856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002666694A Abandoned CA2666694A1 (en) | 2006-08-18 | 2007-08-15 | Electrically actuated annelid |
Country Status (5)
Country | Link |
---|---|
US (1) | US9242073B2 (en) |
EP (1) | EP2063949A1 (en) |
JP (1) | JP2010501209A (en) |
CA (1) | CA2666694A1 (en) |
WO (1) | WO2008022168A1 (en) |
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Also Published As
Publication number | Publication date |
---|---|
US20080125706A1 (en) | 2008-05-29 |
WO2008022168A1 (en) | 2008-02-21 |
JP2010501209A (en) | 2010-01-21 |
US9242073B2 (en) | 2016-01-26 |
EP2063949A1 (en) | 2009-06-03 |
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FZDE | Discontinued |