CA2673991A1 - Methods for coating catheter balloons with a defined quantity of active agent - Google Patents

Methods for coating catheter balloons with a defined quantity of active agent Download PDF

Info

Publication number
CA2673991A1
CA2673991A1 CA002673991A CA2673991A CA2673991A1 CA 2673991 A1 CA2673991 A1 CA 2673991A1 CA 002673991 A CA002673991 A CA 002673991A CA 2673991 A CA2673991 A CA 2673991A CA 2673991 A1 CA2673991 A1 CA 2673991A1
Authority
CA
Canada
Prior art keywords
catheter balloon
coating
fold
coating solution
coated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002673991A
Other languages
French (fr)
Other versions
CA2673991C (en
Inventor
Erika Hoffmann
Roland Horres
Volker Faust
Helmut Schreiber
Armin Von Holst
Michael Hoffmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hemoteq AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39523684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2673991(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Priority to CA2743022A priority Critical patent/CA2743022C/en
Publication of CA2673991A1 publication Critical patent/CA2673991A1/en
Application granted granted Critical
Publication of CA2673991C publication Critical patent/CA2673991C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1027—Making of balloon catheters
    • A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1027—Making of balloon catheters
    • A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
    • A61M2025/1031—Surface processing of balloon members, e.g. coating or deposition; Mounting additional parts onto the balloon member's surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1088—Balloon catheters with special features or adapted for special applications having special surface characteristics depending on material properties or added substances, e.g. for reducing friction

Abstract

The invention relates to methods for coating catheter balloons with a def ined quantity of a pharmacological active ingredient, said coating method us ing a coating device, which is provided with a volumetric measuring unit for dispensing a measurable quantity of coating solution onto the surface of th e catheter balloon in a targeted manner by means of a dispensing device.</SD OAB>

Claims (42)

1 A method for coating a catheter balloon with a defined amount of a pharmacologically active agent, wherein the coating method uses a coating device with a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically to the surface of the catheter balloon.
2. The method according to claim 1, wherein the dispensing device is a nozzle, a plurality of nozzles, a thread, a mesh of threads, a piece of textile, a leather strip, a sponge, a ball, a syringe, a needle, a cannula or a capillary.
3. The method according to claim 1 or 2, wherein the coating method is a squirting method, a pipetting method, a capillary method, a fold spray method, a drag method, a thread drag method or roll method.
4. The method according to claim 1, 2 or 3, wherein the coating solution contains a pharmacologically active agent together with at least one transport mediator, citrate ester, contrast medium, polymer, polysaccharide, peptide, nucleotide, oil, fat, wax, fatty acid, fatty acid ester, hydrogel, salt, solvent, pharmacologically acceptable excipient or a mixture of the aforementioned substances.
5. The method according to one of the claims 1 - 4, comprising the following steps:
a) Providing a folded, packed catheter balloon, b) providing a coating device with an outlet capable for pointwise release of the coating solution, c) setting the aperture capable for pointwise release of the coating solution to the proximal or distal end of a fold of the catheter balloon, d) releasing a defined amount of the coating solution through the outlet at the proximal or distal end of a fold, and e) filling the fold with the coating solution because of capillary effects.
6. The method according to claim 5, wherein a fold is filled within 5 to 80 seconds.
7. The method according to claim 5 or 6, wherein the catheter balloon is inclined by 10° to 65° during the filling of the fold and the filling of the folds is effected from the superior end.
8. The method according to one of the claims 5 - 7, wherein the coating solution doesn't need to be pressed out of the coating device, but fills the fold because of capillary forces and, if the catheter balloon is inclined, because of gravitation.
9. The method according to one of the claims 5 - 8, wherein the catheter balloon is rotated and all folds are filled successively.
10. The method according to one of the claims 5 - 9, wherein the coating device has a plurality of outlets for concomitant coating of a plurality of folds of a catheter balloon.
11. The method according to one of the claims 5 - 10, further comprising method step f) f) drying the coating solution in the fold, wherein the catheter balloon is rotated during drying about its longitudinal axis in direction of the fold opening.
12. The method according to one of the claims 1- 4, comprising the following steps:
a) providing a folded packed catheter balloon, b) providing a coating device with at least one nozzle or at least a syringe-shaped outlet, c) setting the nozzle or the outlet at the proximal or distal end of a fold of the catheter balloon, d) moving the nozzle or the outlet along the fold relative to the fold, and e) releasing a flow of coating solution defined in time and covered distance.
13. The method according to claim 12, wherein the nozzle or outlet is located in the centre of the fold.
14. The method according to claim 12 or 13, wherein a fold is filled within 5 to 80 seconds.
15. The method according to one of the claims 12 - 14, wherein the coating device has a number of nozzles or outlets corresponding to the number of folds and all folds are filled concomitantly.
16. The method according to one of the claims 12 - 15, wherein the coating solution has a melting point or solidification point of less than 20°C
after removing the solvent.
17. The method according to one of the claims 12 - 16, wherein an oily or pasty coating solution is used which doesn't dry completely in the folds.
18. The method according to one of the claims 12 - 17, further comprising the drying step f) f) drying the coating solution in the fold or evenly distributing the coating in the fold, wherein the catheter balloon is rotated about its longitudinal axis in direction of the fold opening.
19. The method according to one of the claims 1- 4, comprising the following steps:
a) providing a folded packed catheter balloon, b) providing a coating device with a plurality of aligned releasing apertures, c) inserting the plurality of aligned releasing apertures under a fold of the catheter balloon, d) concomitant release of a defined amount of the coating solution from the releasing apertures into the fold; and e) drying of the coating solution in the folds.
20. The method according to claim 19, wherein the releasing apertures are located in the centre of the fold.
21. The method according to claim 19 or 20, wherein a fold is filled within 5 to 80 seconds.
22. The method according to one of the claims 19 - 21, wherein the coating device has a number of aligned releasing apertures corresponding to the number of folds and all folds are filled concomitantly.
23. The method according to one of the claims 19 - 22, wherein the coating solution has a melting point or solidification point of less than 20°C
after removing the solvent.
24. The method according to one of the claims 19 - 23, wherein an oily or pasty coating solution is used which doesn't dry completely in the folds.
25. The method according to one of the claims 19 - 24, further comprising the method step f) f) drying the coating solution in the fold or evenly distributing the coating in the fold, wherein the catheter balloon is rotated about its longitudinal axis in direction of the fold opening.
26. The method according to one of the claims 1- 4, comprising the following steps:
a) providing a catheter balloon in a folded, partially inflated or completely inflated state, b) providing a coating device with a dispensing device, c) forming of a drop of the coating solution at the dispensing device, d) dragging the drop over the surface of the catheter balloon to be coated without the dispensing device itself contacting the surface of the catheter balloon, and e) redosing of the coating solution so that the drop substantially maintains its size.
27. The method according to claim 26, wherein specifically only the folds of the catheter balloon are filled by dragging the drop over the opening of the fold.
28. The method according to claim 26 or 27, wherein the surface of the catheter balloon is bedewed before coating with a solvent.
29. The method according to claim 26, 27 or 28, wherein the dispensing device is a needle, syringe, cannula, pipette or nozzle.
30. The method according to one of the claims 1 - 4, comprising the following steps:
a) providing a catheter balloon in a folded, partially inflated or completely inflated state, b) providing a coating device with a dispensing device in form of a thread, sponge, leather strip or piece of textile, c) providing a coating solution, d) soaking the dispensing device with the coating solution, e) transferring the coating solution from the dispensing device onto the surface of the catheter balloon to be coated, and f) redosing of the coating solution so that a consistent dispense of the coating solution from the dispensing device onto the surface of the catheter balloon to be coated occurs.
31. The method according to claim 30, wherein the transfer of the coating solution from the dispensing device onto the surface of the catheter balloon to be coated is effected according to step e) by dragging the dispensing device over the surface of the catheter balloon to be coated.
32. The method according to claim 30 or 31, wherein specifically only the folds of the catheter balloon are filled by dragging the dispensing device over the opening of the fold or through the folds.
33. The method according to one of the claims 30 - 32, wherein the surface of the catheter balloon is bedewed before coating with a solvent.
34. The method according to one of the claims 30 - 33, wherein the dispensing device consists of a material that doesn't damage the catheter balloon.
35. The method according to one of the claims 30 - 34, wherein all folds of the catheter balloon are coated or filled concomitantly.
36. The method according to one of the claims 30 - 35, wherein the complete surface of the catheter balloon is coated concomitantly by a plurality of threads, leather strips, a piece of textile or a mesh of threads.
37. The method according to one of the claims 1 - 4, comprising the following steps:
a) providing a coating device with a ballpoint for transferring the coating solution onto the surface of the catheter balloon to be coated, b) providing a coating solution with access to the ballpoint, c) setting the ballpoint of the coating device onto the surface of the catheter balloon to be coated, d) exerting a pressure on the ballpoint of the coating device for enabling the outflow of the coating solution, and e) tracing the surface of the catheter balloon to be coated with the ballpoint thus transferring the coating solution onto the surface of the catheter balloon to be coated.
38. The method according to claim 37, wherein the complete surface of the catheter balloon to be coated is traced and coated by the ball in one pass.
39. The method according to claim 37 or 38, wherein the thickness of the layer is controlled through the pressure exerted on the ballpoint and the displacement velocity of the ballpoint over the surface of the catheter balloon to be coated.
40. A device for the coating of surfaces of catheter balloons comprising a coating device with a ballpoint having a feed line for the coating solution onto the ballpoint and a control for setting the ballpoint on the surface of the catheter balloon and for tracing the surface of the catheter balloon to be coated with the ballpoint.
41. The device according to claim 40, wherein the ballpoint consists of a rubber-like material and not of a metal.
42. A coated catheter balloon available from a method according to one of the claims 1 - 39.
CA2673991A 2007-01-21 2008-01-21 Methods for coating catheter balloons with a defined quantity of active agent Active CA2673991C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2743022A CA2743022C (en) 2007-01-21 2008-01-21 Methods for coating catheter balloons with a defined quantity of active agent

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE102007003914 2007-01-21
DE102007003914.1 2007-01-21
DE102007006557 2007-02-09
DE102007006557.6 2007-02-09
DE102007013586 2007-03-21
DE102007013586.8 2007-03-21
PCT/DE2008/000096 WO2008086794A2 (en) 2007-01-21 2008-01-21 Medical product for treating stenosis of body passages and for preventing threatening restenosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2743022A Division CA2743022C (en) 2007-01-21 2008-01-21 Methods for coating catheter balloons with a defined quantity of active agent

Publications (2)

Publication Number Publication Date
CA2673991A1 true CA2673991A1 (en) 2008-07-24
CA2673991C CA2673991C (en) 2012-02-07

Family

ID=39523684

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2743022A Active CA2743022C (en) 2007-01-21 2008-01-21 Methods for coating catheter balloons with a defined quantity of active agent
CA2673991A Active CA2673991C (en) 2007-01-21 2008-01-21 Methods for coating catheter balloons with a defined quantity of active agent

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2743022A Active CA2743022C (en) 2007-01-21 2008-01-21 Methods for coating catheter balloons with a defined quantity of active agent

Country Status (17)

Country Link
US (2) US8597720B2 (en)
EP (3) EP2269664B1 (en)
JP (2) JP4906926B2 (en)
KR (3) KR101198980B1 (en)
CN (2) CN101687066B (en)
AU (2) AU2008207191B2 (en)
BR (2) BRPI0823269B8 (en)
CA (2) CA2743022C (en)
DE (1) DE112008000881A5 (en)
ES (2) ES2409759T3 (en)
IL (2) IL199568A (en)
MX (2) MX336844B (en)
NZ (2) NZ578341A (en)
PL (2) PL2136853T3 (en)
RU (2) RU2447901C2 (en)
WO (1) WO2008086794A2 (en)
ZA (1) ZA201007601B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102573946A (en) * 2009-10-16 2012-07-11 汉莫堤克股份有限公司 Use of compositions to coat catheter balloons and coated catheter balloons
WO2019222843A1 (en) * 2018-05-22 2019-11-28 Interface Biologics, Inc. Compositions and methods for delivering drugs to a vessel wall

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8177743B2 (en) 1998-05-18 2012-05-15 Boston Scientific Scimed, Inc. Localized delivery of drug agents
US20090062909A1 (en) 2005-07-15 2009-03-05 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
FR2892939B1 (en) * 2005-11-10 2010-01-22 Groupement Coeur Artificiel Total Carpentier Matra Carmat COMPOSITE HEMOCOMPATIBLE MATERIAL AND METHOD FOR OBTAINING THE SAME
US8287940B2 (en) * 2006-02-09 2012-10-16 B. Braun Melsungen Ag Coating method for a folded balloon
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8430055B2 (en) 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US20080175887A1 (en) 2006-11-20 2008-07-24 Lixiao Wang Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
RU2447901C2 (en) 2007-01-21 2012-04-20 Хемотек Аг Medical device for treating lumen obturations and preventing threatening recurrent obturations
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
DE102007036685A1 (en) 2007-08-03 2009-02-05 Innora Gmbh Improved drug-coated medical devices their manufacture and use
US8162880B2 (en) * 2008-01-18 2012-04-24 Swaminathan Jayaraman Delivery of therapeutic and marking substance through intra lumen expansion of a delivery device
WO2009111716A1 (en) 2008-03-06 2009-09-11 Boston Scientific Scimed, Inc. Balloon catheter devices with sheath covering
JP5667559B2 (en) * 2008-03-28 2015-02-12 サーモディクス，インコーポレイティド Insertable medical device having an elastic matrix with microparticles disposed thereon, and drug delivery method
EP2271294B1 (en) 2008-04-17 2018-03-28 Micell Technologies, Inc. Stents having bioabsorbable layers
WO2009135125A2 (en) * 2008-05-01 2009-11-05 Bayer Schering Pharma Ag Catheter balloon drug adherence techniques and methods
DE102008002471A1 (en) 2008-06-17 2009-12-24 Biotronik Vi Patent Ag Stent with a coating or a base body containing a lithium salt, and use of lithium salts for restenosis prophylaxis
JP2011528275A (en) 2008-07-17 2011-11-17 ミセル テクノロジーズ，インク． Drug delivery medical device
DE102008034826A1 (en) * 2008-07-22 2010-01-28 Alexander Rübben A method of creating a bioactive surface on the balloon of a balloon catheter
IT1394522B1 (en) 2009-01-09 2012-07-05 Invatec Technology Ct Gmbh MEDICAL DEVICE WITH DRUG RELEASE
CN102481195B (en) 2009-04-01 2015-03-25 米歇尔技术公司 Drug delivery medical device
AU2010261804A1 (en) 2009-06-17 2012-01-12 Dot Gmbh Method and device for coating catheters or balloon catheters
EP3064230B1 (en) 2009-07-10 2019-04-10 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
EP2453834A4 (en) 2009-07-16 2014-04-16 Micell Technologies Inc Drug delivery medical device
EP2453938B1 (en) 2009-07-17 2015-08-19 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US11369498B2 (en) 2010-02-02 2022-06-28 MT Acquisition Holdings LLC Stent and stent delivery system with improved deliverability
WO2011133655A1 (en) 2010-04-22 2011-10-27 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
DE102010022588A1 (en) * 2010-05-27 2011-12-01 Hemoteq Ag Balloon catheter with a particle-free drug-releasing coating
CA2805631C (en) 2010-07-16 2018-07-31 Micell Technologies, Inc. Drug delivery medical device
EP2611476B1 (en) 2010-09-02 2016-08-10 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
WO2012039884A1 (en) 2010-09-23 2012-03-29 Boston Scientific Scimed, Inc. Drug coated balloon with transferable coating
DE102010055562B4 (en) * 2010-12-23 2015-07-09 Heraeus Medical Gmbh Coating device and coating method
US9272095B2 (en) * 2011-04-01 2016-03-01 Sio2 Medical Products, Inc. Vessels, contact surfaces, and coating and inspection apparatus and methods
WO2013007273A1 (en) * 2011-07-08 2013-01-17 Cardionovum Sp.Z.O.O. Balloon surface coating
CA2841360A1 (en) 2011-07-15 2013-01-24 Micell Technologies, Inc. Drug delivery medical device
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
JP6076351B2 (en) 2011-09-29 2017-02-08 カーディオノブーム エスぺー． ゼット． オー． オー． Balloon surface coating
WO2014063111A1 (en) * 2012-10-18 2014-04-24 Micell Technologyies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
DE102011117526B4 (en) * 2011-11-03 2015-07-30 Heraeus Medical Gmbh Coating method and coating device for medical implants
WO2013091722A1 (en) 2011-12-23 2013-06-27 Innora Gmbh Drug-coated medical devices
WO2013146376A1 (en) 2012-03-27 2013-10-03 テルモ株式会社 Coating composition and medical device
CN104203297B (en) * 2012-03-27 2016-04-06 泰尔茂株式会社 Coating composition and medical apparatus and instruments
JP6549482B2 (en) * 2012-06-01 2019-07-24 サーモディクス，インコーポレイテッド Device and method for coating a balloon catheter
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
WO2014029442A1 (en) 2012-08-23 2014-02-27 Cardionovum Gmbh Balloon surface coating for valvuloplasty
US11090468B2 (en) * 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
CA2889062C (en) * 2012-10-25 2022-06-21 Surmodics, Inc. Apparatus and methods for coating medical devices
US20140172118A1 (en) * 2012-12-19 2014-06-19 Cook Medical Technologies Llc Bioactive Compositions, Bioactive Eluting Devices and Methods of Use Thereof
KR20150143476A (en) 2013-03-12 2015-12-23 미셀 테크놀로지즈, 인코포레이티드 Bioabsorbable biomedical implants
JP2016512151A (en) * 2013-03-14 2016-04-25 テレフレックス メディカル インコーポレイテッドＴｅｌｅｆｌｅｘ Ｍｅｄｉｃａｌ Ｉｎｃｏｒｐｏｒａｔｅｄ Local drug delivery
US9872940B2 (en) 2013-04-01 2018-01-23 Terumo Kabushiki Kaisha Drug coating layer
EP2789354A1 (en) 2013-04-13 2014-10-15 IPPyramids GmbH Catheter balloon with micro boreholes and a metal mesh
KR102079613B1 (en) 2013-05-15 2020-02-20 미셀 테크놀로지즈, 인코포레이티드 Bioabsorbable biomedical implants
EP3862031B1 (en) * 2013-11-08 2023-08-09 Hollister Incorporated Oleophilic lubricated catheters
CN104174074B (en) * 2013-11-27 2016-05-18 浙江归创医疗器械有限公司 A kind of medication coat composition that is applicable to be coated in implantation or interventional medical device surface
EP3106197B1 (en) * 2014-04-01 2018-09-26 Terumo Kabushiki Kaisha Balloon coating method
WO2015151877A1 (en) * 2014-04-01 2015-10-08 テルモ株式会社 Balloon coating method, coat layer control method and balloon coating device
EP3106196B1 (en) 2014-04-01 2019-09-18 Terumo Kabushiki Kaisha Positioning method for balloon coating
EP3106198B1 (en) * 2014-04-01 2019-09-18 Terumo Kabushiki Kaisha Positioning method for balloon coating
US10143779B2 (en) 2014-05-16 2018-12-04 Terumo Kabushiki Kaisha Method of inhibiting thickening of vascular intima
US10149925B2 (en) 2014-05-16 2018-12-11 Terumo Kabushiki Kaisha Method of reducing the risk of embolization of peripheral blood vessels
US10188771B2 (en) 2014-05-16 2019-01-29 Terumo Kabushiki Kaisha Method of treating peripheral artery diseases in lower limbs
US11406742B2 (en) * 2014-07-18 2022-08-09 M.A. Med Alliance SA Coating for intraluminal expandable catheter providing contact transfer of drug micro-reservoirs
CN106178233A (en) * 2014-12-26 2016-12-07 先健科技(深圳)有限公司 The preparation method of medicine balloon dilating catheter and flap winding sacculus
US10022523B2 (en) 2015-04-23 2018-07-17 Terumo Kabushiki Kaisha Balloon coating method and balloon rotating method
EP3287166A4 (en) 2015-04-23 2018-12-19 Terumo Kabushiki Kaisha Balloon coating method, balloon rotation method, and balloon coating device
JP6778507B2 (en) 2015-04-23 2020-11-04 テルモ株式会社 Balloon coating method, balloon rotation method and balloon coating device
US9901719B2 (en) 2015-04-23 2018-02-27 Terumo Kabushiki Kaisha Balloon coating method, balloon rotating method and balloon coating apparatus
US10427184B2 (en) 2015-04-23 2019-10-01 Terumo Kabushiki Kaisha Balloon coating method, balloon rotating method and balloon coating apparatus
CN107530529A (en) 2015-04-23 2018-01-02 泰尔茂株式会社 Sacculus coating method, sacculus spinning solution and sacculus applying device
BR112018008738B1 (en) * 2015-10-30 2022-06-21 Acotec Scientific Co. Ltd Drug coated balloon catheter
CN108601608B (en) * 2015-12-02 2021-06-18 纽莱斯科公司 Device and method for emergency treatment of cardiac arrest
ES2951010T3 (en) * 2016-02-01 2023-10-17 Schierholz Joerg Michael Implantable health products, procedure for their preparation and use thereof
US10905457B2 (en) 2016-06-06 2021-02-02 Terumo Kabushiki Kaisha Device handle for a medical device
WO2017223182A1 (en) * 2016-06-22 2017-12-28 Medchem Partners, Llc. Nitric oxide donors
CN106621003A (en) * 2016-11-10 2017-05-10 乐普（北京）医疗器械股份有限公司 Drug balloon catheter and preparation method and application thereof
US10349528B2 (en) * 2017-02-21 2019-07-09 Palo Alto Research Center Incorporated Spring loaded rollerball pen for deposition of materials on raised surfaces
WO2018183389A1 (en) * 2017-03-28 2018-10-04 Allied Bioscience, Inc. Antimicrobial coatings for medical implements and medical devices
CN107458913A (en) * 2017-08-02 2017-12-12 安徽省无为天成纺织有限公司 A kind of textile yarn saving applicator
JP2018069080A (en) * 2017-11-15 2018-05-10 ルトニックス，インコーポレーテッド Drug-release coating for medical device
JP7198218B2 (en) * 2017-11-22 2022-12-28 テルモ株式会社 Drug application device and method for forming drug layer
CN108580197B (en) * 2018-04-23 2019-12-03 青岛西海岸市政工程有限公司 A kind of pipe material inner wall waterproof layer application device and smearing method
CN109550634B (en) * 2018-11-16 2020-11-27 福州兴创云达新材料科技有限公司 Automatic coating device and control method for high-performance soldering flux
US11628466B2 (en) 2018-11-29 2023-04-18 Surmodics, Inc. Apparatus and methods for coating medical devices
CN109696447B (en) * 2018-12-29 2020-10-16 苏州瑞派宁科技有限公司 Soft X-ray microscopic imaging device
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
DE102019116791B4 (en) * 2019-06-21 2023-10-26 InnoRa Gesellschaft mbH Stent with immediately removable coating
CN111122523B (en) * 2019-12-06 2021-09-28 山西大学 Quick recognition Ag+Cys-combined molecular logic gate with three-phase output function and construction method thereof
DE102020101197A1 (en) * 2020-01-20 2021-07-22 Charité - Universitätsmedizin Berlin Medical device for drug delivery with enhanced effect
EP4262905A1 (en) * 2020-12-18 2023-10-25 The Cleveland Clinic Foundation Dual agent nanoparticle composition for coating medical devices

Family Cites Families (557)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US304121A (en) 1884-08-26 Helm munch
US2098381A (en) 1935-08-14 1937-11-09 Kleinert I B Rubber Co Safety device
CS173836B1 (en) 1974-03-19 1977-03-31
FR2283089A1 (en) * 1974-08-02 1976-03-26 Ugine Kuhlmann BROMINE MANUFACTURING PROCESS
US4186745A (en) 1976-07-30 1980-02-05 Kauzlarich James J Porous catheters
US4481323A (en) 1980-05-07 1984-11-06 Medical Research Associates, Ltd. #2 Hydrocarbon block copolymer with dispersed polysiloxane
US4364392A (en) 1980-12-04 1982-12-21 Wisconsin Alumni Research Foundation Detachable balloon catheter
CA1191064A (en) 1981-12-31 1985-07-30 Bard (C. R.), Inc. Catheter with selectively rigidified portion
US4515593A (en) 1981-12-31 1985-05-07 C. R. Bard, Inc. Medical tubing having exterior hydrophilic coating for microbiocide absorption therein and method for using same
US4769013A (en) 1982-09-13 1988-09-06 Hydromer, Inc. Bio-effecting medical material and device
NZ205680A (en) 1982-10-01 1986-05-09 Ethicon Inc Glycolide/epsilon-caprolactone copolymers and sterile surgical articles made therefrom
US4603152A (en) 1982-11-05 1986-07-29 Baxter Travenol Laboratories, Inc. Antimicrobial compositions
US4644936A (en) 1982-11-19 1987-02-24 Iabp Percutaneous intra-aortic balloon and method for using same
US4693243A (en) 1983-01-14 1987-09-15 Buras Sharon Y Conduit system for directly administering topical anaesthesia to blocked laryngeal-tracheal areas
US4490421A (en) 1983-07-05 1984-12-25 E. I. Du Pont De Nemours And Company Balloon and manufacture thereof
US4589873A (en) 1984-05-29 1986-05-20 Becton, Dickinson And Company Method of applying a hydrophilic coating to a polymeric substrate and articles prepared thereby
US4931583A (en) 1984-06-11 1990-06-05 Morflex Chemical Compay, Inc. Citrate esters
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4784647A (en) 1986-07-30 1988-11-15 The Kendal Company Catheter meatal pad device
US5250069A (en) 1987-02-27 1993-10-05 Terumo Kabushiki Kaisha Catheter equipped with expansible member and production method thereof
US4800882A (en) * 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4796629A (en) * 1987-06-03 1989-01-10 Joseph Grayzel Stiffened dilation balloon catheter device
US4886062A (en) 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
US4950256A (en) 1988-04-07 1990-08-21 Luther Medical Products, Inc. Non-thrombogenic intravascular time release catheter
DE8904026U1 (en) * 1988-04-20 1989-05-24 Schneider (Europe) Ag, Zuerich, Ch
JP2683750B2 (en) 1988-06-06 1997-12-03 住友電気工業株式会社 Catheter balloon
DE3821544C2 (en) 1988-06-25 1994-04-28 H Prof Dr Med Just Dilatation catheter
US6730105B2 (en) 1988-07-29 2004-05-04 Samuel Shiber Clover leaf shaped tubular medical device
US4950239A (en) 1988-08-09 1990-08-21 Worldwide Medical Plastics Inc. Angioplasty balloons and balloon catheters
US5169933A (en) 1988-08-15 1992-12-08 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
US5328471A (en) 1990-02-26 1994-07-12 Endoluminal Therapeutics, Inc. Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
US5213580A (en) 1988-08-24 1993-05-25 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process
DE68922497T2 (en) 1988-08-24 1995-09-14 Marvin J Slepian ENDOLUMINAL SEAL WITH BISDEGRADABLE POLYMERS.
US4906244A (en) * 1988-10-04 1990-03-06 Cordis Corporation Balloons for medical devices and fabrication thereof
US5091205A (en) 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
FR2642474B1 (en) 1989-01-27 1992-05-15 Floquet Monopole HOLLOW SHAFT, ESPECIALLY FOR AN INTERNAL COMBUSTION ENGINE PISTON, AND ITS MANUFACTURING METHOD
DE69023362T2 (en) 1989-01-31 1996-04-04 Bard Inc C R Catheter and method for locally applied medication of the wall of a blood vessel or other body lumen.
US5087244A (en) 1989-01-31 1992-02-11 C. R. Bard, Inc. Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen
US6146358A (en) 1989-03-14 2000-11-14 Cordis Corporation Method and apparatus for delivery of therapeutic agent
US5041100A (en) 1989-04-28 1991-08-20 Cordis Corporation Catheter and hydrophilic, friction-reducing coating thereon
US4994033A (en) 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5049131A (en) 1989-05-31 1991-09-17 Ashridge Ag Balloon catheter
US5026607A (en) 1989-06-23 1991-06-25 C. R. Bard, Inc. Medical apparatus having protective, lubricious coating
DE69002295T2 (en) 1989-09-25 1993-11-04 Schneider Usa Inc MULTILAYER EXTRUSION AS A METHOD FOR PRODUCING BALLOONS FOR VESSEL PLASTICS.
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5135516A (en) 1989-12-15 1992-08-04 Boston Scientific Corporation Lubricious antithrombogenic catheters, guidewires and coatings
US5674192A (en) 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5843089A (en) 1990-12-28 1998-12-01 Boston Scientific Corporation Stent lining
US5439446A (en) 1994-06-30 1995-08-08 Boston Scientific Corporation Stent and therapeutic delivery system
DE69110787T2 (en) 1990-02-28 1996-04-04 Medtronic Inc INTRALUMINAL PROSTHESIS WITH ACTIVE ELEMENTATION.
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5092841A (en) * 1990-05-17 1992-03-03 Wayne State University Method for treating an arterial wall injured during angioplasty
AU7998091A (en) 1990-05-17 1991-12-10 Harbor Medical Devices, Inc. Medical device polymer
US5199951A (en) 1990-05-17 1993-04-06 Wayne State University Method of drug application in a transporting medium to an arterial wall injured during angioplasty
US5499971A (en) * 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
US5498238A (en) * 1990-06-15 1996-03-12 Cortrak Medical, Inc. Simultaneous angioplasty and phoretic drug delivery
EP0533816B1 (en) * 1990-06-15 1995-06-14 Cortrak Medical, Inc. Drug delivery apparatus
US5320634A (en) 1990-07-03 1994-06-14 Interventional Technologies, Inc. Balloon catheter with seated cutting edges
US5196024A (en) 1990-07-03 1993-03-23 Cedars-Sinai Medical Center Balloon catheter with cutting edge
US5180366A (en) * 1990-10-10 1993-01-19 Woods W T Apparatus and method for angioplasty and for preventing re-stenosis
US5342628A (en) 1990-10-11 1994-08-30 Applied Medical Research, Inc. Drug diffusion polymer system and method
WO1992008510A1 (en) * 1990-11-09 1992-05-29 Boston Scientific Corporation Guidewire for crossing occlusions in blood vessels
US6524274B1 (en) * 1990-12-28 2003-02-25 Scimed Life Systems, Inc. Triggered release hydrogel drug delivery system
US5102402A (en) 1991-01-04 1992-04-07 Medtronic, Inc. Releasable coatings on balloon catheters
US5893840A (en) 1991-01-04 1999-04-13 Medtronic, Inc. Releasable microcapsules on balloon catheters
US5324261A (en) 1991-01-04 1994-06-28 Medtronic, Inc. Drug delivery balloon catheter with line of weakness
DE4117782C2 (en) 1991-05-28 1997-07-17 Diagnostikforschung Inst Nanocrystalline magnetic iron oxide particles, processes for their production and diagnostic and / or therapeutic agents
US5213576A (en) 1991-06-11 1993-05-25 Cordis Corporation Therapeutic porous balloon catheter
US5318531A (en) 1991-06-11 1994-06-07 Cordis Corporation Infusion balloon catheter
US5264260A (en) 1991-06-20 1993-11-23 Saab Mark A Dilatation balloon fabricated from low molecular weight polymers
CA2074304C (en) 1991-08-02 1996-11-26 Cyril J. Schweich, Jr. Drug delivery catheter
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5500013A (en) 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
JP3053029B2 (en) 1991-10-08 2000-06-19 テルモ株式会社 Vascular dilatation catheter balloon
EP0572624A4 (en) 1991-12-18 1994-07-06 Scimed Life Systems Inc Lubricous polymer network
CA2086642C (en) 1992-01-09 2004-06-15 Randall E. Morris Method of treating hyperproliferative vascular disease
US5599352A (en) 1992-03-19 1997-02-04 Medtronic, Inc. Method of making a drug eluting stent
US5282823A (en) 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US5571166A (en) 1992-03-19 1996-11-05 Medtronic, Inc. Method of making an intraluminal stent
US5254089A (en) 1992-04-02 1993-10-19 Boston Scientific Corp. Medication dispensing balloon catheter
EP0569263B1 (en) 1992-04-06 1997-07-02 Terumo Kabushiki Kaisha Balloon catheter
AU670937B2 (en) 1992-04-28 1996-08-08 Wyeth Method of treating hyperproliferative vascular disease
US5368566A (en) 1992-04-29 1994-11-29 Cardiovascular Dynamics, Inc. Delivery and temporary stent catheter having a reinforced perfusion lumen
US5569184A (en) 1992-04-29 1996-10-29 Cardiovascular Dynamics, Inc. Delivery and balloon dilatation catheter and method of using
US5629008A (en) 1992-06-02 1997-05-13 C.R. Bard, Inc. Method and device for long-term delivery of drugs
US5383928A (en) * 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
GB9213077D0 (en) 1992-06-19 1992-08-05 Erba Carlo Spa Polymerbound taxol derivatives
US5500180A (en) * 1992-09-30 1996-03-19 C. R. Bard, Inc. Method of making a distensible dilatation balloon using a block copolymer
US5489525A (en) * 1992-10-08 1996-02-06 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibodies to prostate cells
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5634901A (en) * 1992-11-02 1997-06-03 Localmed, Inc. Method of using a catheter sleeve
US5449382A (en) 1992-11-04 1995-09-12 Dayton; Michael P. Minimally invasive bioactivated endoprosthesis for vessel repair
US5578075B1 (en) 1992-11-04 2000-02-08 Daynke Res Inc Minimally invasive bioactivated endoprosthesis for vessel repair
US5807306A (en) 1992-11-09 1998-09-15 Cortrak Medical, Inc. Polymer matrix drug delivery apparatus
US5688516A (en) * 1992-11-12 1997-11-18 Board Of Regents, The University Of Texas System Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices
US5419760A (en) 1993-01-08 1995-05-30 Pdt Systems, Inc. Medicament dispensing stent for prevention of restenosis of a blood vessel
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
WO1994021320A1 (en) * 1993-03-15 1994-09-29 Advanced Cardiovascular Systems, Inc. Fluid delivery catheter
WO1994021308A1 (en) 1993-03-18 1994-09-29 Cedars-Sinai Medical Center Drug incorporating and releasing polymeric coating for bioprosthesis
WO1994023787A1 (en) 1993-04-22 1994-10-27 Rammler David H Sampling balloon catheter
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5344402A (en) 1993-06-30 1994-09-06 Cardiovascular Dynamics, Inc. Low profile perfusion catheter
US5994341A (en) * 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
US5599307A (en) * 1993-07-26 1997-02-04 Loyola University Of Chicago Catheter and method for the prevention and/or treatment of stenotic processes of vessels and cavities
US5380299A (en) * 1993-08-30 1995-01-10 Med Institute, Inc. Thrombolytic treated intravascular medical device
WO1995009667A1 (en) 1993-10-01 1995-04-13 Boston Scientific Corporation Medical device balloons containing thermoplastic elastomers
US6146356A (en) 1994-03-02 2000-11-14 Scimed Life Systems, Inc. Block copolymer elastomer catheter balloons
ES2141928T5 (en) 1994-03-02 2009-04-16 Boston Scientific Limited BALLS OF ELASTOMERO COPOLIMERO IN BLOCKS FOR CATHETER.
US5470307A (en) 1994-03-16 1995-11-28 Lindall; Arnold W. Catheter system for controllably releasing a therapeutic agent at a remote tissue site
US5588962A (en) 1994-03-29 1996-12-31 Boston Scientific Corporation Drug treatment of diseased sites deep within the body
US5599306A (en) * 1994-04-01 1997-02-04 Localmed, Inc. Method and apparatus for providing external perfusion lumens on balloon catheters
WO1995029729A1 (en) 1994-04-29 1995-11-09 Boston Scientific Corporation Novel micro occlusion balloon catheter
US5857998A (en) * 1994-06-30 1999-01-12 Boston Scientific Corporation Stent and therapeutic delivery system
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
DE4428851C2 (en) 1994-08-04 2000-05-04 Diagnostikforschung Inst Nanoparticles containing iron, their production and application in diagnostics and therapy
US5891108A (en) 1994-09-12 1999-04-06 Cordis Corporation Drug delivery stent
US5707385A (en) * 1994-11-16 1998-01-13 Advanced Cardiovascular Systems, Inc. Drug loaded elastic membrane and method for delivery
CA2163837C (en) 1994-12-13 1999-07-20 Robert K. Perrone Crystalline paclitaxel hydrates
US5599576A (en) 1995-02-06 1997-02-04 Surface Solutions Laboratories, Inc. Medical apparatus with scratch-resistant coating and method of making same
US5869127A (en) * 1995-02-22 1999-02-09 Boston Scientific Corporation Method of providing a substrate with a bio-active/biocompatible coating
US5702754A (en) 1995-02-22 1997-12-30 Meadox Medicals, Inc. Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings
EP0810845A2 (en) 1995-02-22 1997-12-10 Menlo Care Inc. Covered expanding mesh stent
US5605696A (en) 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
DE19515820A1 (en) 1995-04-29 1996-10-31 Inst Neue Mat Gemein Gmbh Process for the production of weakly agglomerated nanoscale particles
US5833657A (en) 1995-05-30 1998-11-10 Ethicon, Inc. Single-walled balloon catheter with non-linear compliance characteristic
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5766201A (en) 1995-06-07 1998-06-16 Boston Scientific Corporation Expandable catheter
US7611533B2 (en) 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US5865801A (en) * 1995-07-18 1999-02-02 Houser; Russell A. Multiple compartmented balloon catheter with external pressure sensing
US6283951B1 (en) * 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
DE19539449A1 (en) 1995-10-24 1997-04-30 Biotronik Mess & Therapieg Process for the production of intraluminal stents from bioresorbable polymer material
US5728066A (en) * 1995-12-13 1998-03-17 Daneshvar; Yousef Injection systems and methods
US6234951B1 (en) 1996-02-29 2001-05-22 Scimed Life Systems, Inc. Intravascular radiation delivery system
US6099454A (en) 1996-02-29 2000-08-08 Scimed Life Systems, Inc. Perfusion balloon and radioactive wire delivery system
US5855546A (en) 1996-02-29 1999-01-05 Sci-Med Life Systems Perfusion balloon and radioactive wire delivery system
ATE314843T1 (en) 1996-03-12 2006-02-15 Pg Txl Co Lp WATER SOLUBLE PACLITAXEL PRODRUGS
DE19614136A1 (en) 1996-04-10 1997-10-16 Inst Neue Mat Gemein Gmbh Process for the production of agglomerate-free nanoscale iron oxide particles with a hydrolysis-resistant coating
US5833658A (en) 1996-04-29 1998-11-10 Levy; Robert J. Catheters for the delivery of solutions and suspensions
EP1616563A3 (en) 1996-05-24 2006-01-25 Angiotech Pharmaceuticals, Inc. Perivascular administration of anti-angiogenic factors for treating or preventing vascular diseases
US5928279A (en) 1996-07-03 1999-07-27 Baxter International Inc. Stented, radially expandable, tubular PTFE grafts
US20020042645A1 (en) 1996-07-03 2002-04-11 Shannon Donald T. Drug eluting radially expandable tubular stented grafts
US5830217A (en) 1996-08-09 1998-11-03 Thomas J. Fogarty Soluble fixation device and method for stent delivery catheters
EP0835673A3 (en) 1996-10-10 1998-09-23 Schneider (Usa) Inc. Catheter for tissue dilatation and drug delivery
US5704908A (en) * 1996-10-10 1998-01-06 Genetronics, Inc. Electroporation and iontophoresis catheter with porous balloon
US6197013B1 (en) 1996-11-06 2001-03-06 Setagon, Inc. Method and apparatus for drug and gene delivery
US7229413B2 (en) 1996-11-06 2007-06-12 Angiotech Biocoatings Corp. Echogenic coatings with overcoat
US5868719A (en) * 1997-01-15 1999-02-09 Boston Scientific Corporation Drug delivery balloon catheter device
US6511477B2 (en) * 1997-03-13 2003-01-28 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
PT981381E (en) 1997-05-12 2007-04-30 Metabolix Inc Polyhydroxyalkanoates for in vivo applications
DE19726282A1 (en) 1997-06-20 1998-12-24 Inst Neue Mat Gemein Gmbh Nanoscale particles with an iron oxide-containing core surrounded by at least two shells
US5902299A (en) 1997-07-29 1999-05-11 Jayaraman; Swaminathan Cryotherapy method for reducing tissue injury after balloon angioplasty or stent implantation
US6245103B1 (en) 1997-08-01 2001-06-12 Schneider (Usa) Inc Bioabsorbable self-expanding stent
US6306166B1 (en) * 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
US5854382A (en) 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
US6592548B2 (en) 1997-09-18 2003-07-15 Iowa-India Investments Company Limited Of Douglas Delivery mechanism for balloons, drugs, stents and other physical/mechanical agents and method of use
US20030233068A1 (en) 1997-09-18 2003-12-18 Swaminathan Jayaraman Delivery mechanism for balloons, drugs, stents and other physical/mechanical agents and method of use
US7445792B2 (en) 2003-03-10 2008-11-04 Abbott Laboratories Medical device having a hydration inhibitor
DE69828963T2 (en) 1997-10-01 2006-01-26 Medtronic AVE, Inc., Santa Rosa Drug delivery and gene therapy delivery system
WO1999024104A1 (en) 1997-11-07 1999-05-20 Ave Connaught Balloon catheter for repairing bifurcated vessels
US5971979A (en) * 1997-12-02 1999-10-26 Odyssey Technologies, Inc. Method for cryogenic inhibition of hyperplasia
US6099926A (en) 1997-12-12 2000-08-08 Intella Interventional Systems, Inc. Aliphatic polyketone compositions and medical devices
US6093463A (en) 1997-12-12 2000-07-25 Intella Interventional Systems, Inc. Medical devices made from improved polymer blends
IT1302061B1 (en) * 1998-02-24 2000-07-20 Sorin Biomedica Cardio Spa COATED VASCULAR PROSTHESIS AND PROCEDURE FOR ITS PRODUCTION.
AU3212199A (en) 1998-03-31 1999-10-18 Scimed Life Systems, Inc. Temperature controlled solute delivery system
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US6364856B1 (en) 1998-04-14 2002-04-02 Boston Scientific Corporation Medical device with sponge coating for controlled drug release
WO1999055396A1 (en) 1998-04-27 1999-11-04 Surmodics, Inc. Bioactive agent release coating
US6240407B1 (en) 1998-04-29 2001-05-29 International Business Machines Corp. Method and apparatus for creating an index in a database system
US6206283B1 (en) 1998-12-23 2001-03-27 At&T Corp. Method and apparatus for transferring money via a telephone call
US6280411B1 (en) 1998-05-18 2001-08-28 Scimed Life Systems, Inc. Localized delivery of drug agents
US8177743B2 (en) 1998-05-18 2012-05-15 Boston Scientific Scimed, Inc. Localized delivery of drug agents
DE19856983A1 (en) 1998-06-25 1999-12-30 Biotronik Mess & Therapieg Implantable, bioresorbable vascular wall support, in particular coronary stent
DE59913189D1 (en) 1998-06-25 2006-05-04 Biotronik Ag Implantable, bioabsorbable vessel wall support, in particular coronary stent
US6369039B1 (en) 1998-06-30 2002-04-09 Scimed Life Sytems, Inc. High efficiency local drug delivery
JP4898991B2 (en) 1998-08-20 2012-03-21 クック メディカル テクノロジーズ エルエルシー Sheathed medical device
US8257724B2 (en) 1998-09-24 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US20060240070A1 (en) 1998-09-24 2006-10-26 Cromack Keith R Delivery of highly lipophilic agents via medical devices
US6299980B1 (en) 1998-09-29 2001-10-09 Medtronic Ave, Inc. One step lubricious coating
US6296619B1 (en) 1998-12-30 2001-10-02 Pharmasonics, Inc. Therapeutic ultrasonic catheter for delivering a uniform energy dose
US6955661B1 (en) 1999-01-25 2005-10-18 Atrium Medical Corporation Expandable fluoropolymer device for delivery of therapeutic agents and method of making
US7572245B2 (en) 2003-09-15 2009-08-11 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using an expandable medical device
US6419692B1 (en) 1999-02-03 2002-07-16 Scimed Life Systems, Inc. Surface protection method for stents and balloon catheters for drug delivery
US6514245B1 (en) * 1999-03-15 2003-02-04 Cryovascular Systems, Inc. Safety cryotherapy catheter
US6432102B2 (en) 1999-03-15 2002-08-13 Cryovascular Systems, Inc. Cryosurgical fluid supply
US6648879B2 (en) 1999-02-24 2003-11-18 Cryovascular Systems, Inc. Safety cryotherapy catheter
US6428534B1 (en) 1999-02-24 2002-08-06 Cryovascular Systems, Inc. Cryogenic angioplasty catheter
US6468297B1 (en) 1999-02-24 2002-10-22 Cryovascular Systems, Inc. Cryogenically enhanced intravascular interventions
DE19908318A1 (en) 1999-02-26 2000-08-31 Michael Hoffmann Hemocompatible surfaces and methods of making them
DE19912798C1 (en) 1999-03-10 2000-02-17 Andreas Jordan Culturing human cancer cells for molecular biology research comprises culturing fragments of tissue slices
US6200257B1 (en) 1999-03-24 2001-03-13 Proxima Therapeutics, Inc. Catheter with permeable hydrogel membrane
EP2305324B1 (en) 1999-03-25 2014-09-17 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US6186745B1 (en) * 1999-04-28 2001-02-13 Chemand Corporation Gas pressurized liquid pump with intermediate chamber
US6368346B1 (en) 1999-06-03 2002-04-09 American Medical Systems, Inc. Bioresorbable stent
US7306625B1 (en) 1999-06-24 2007-12-11 Abbott Laboratories Balloon expandable stent
US6283947B1 (en) 1999-07-13 2001-09-04 Advanced Cardiovascular Systems, Inc. Local drug delivery injection catheter
US6494862B1 (en) * 1999-07-13 2002-12-17 Advanced Cardiovascular Systems, Inc. Substance delivery apparatus and a method of delivering a therapeutic substance to an anatomical passageway
US6203551B1 (en) * 1999-10-04 2001-03-20 Advanced Cardiovascular Systems, Inc. Chamber for applying therapeutic substances to an implant device
US6682545B1 (en) * 1999-10-06 2004-01-27 The Penn State Research Foundation System and device for preventing restenosis in body vessels
US6733513B2 (en) * 1999-11-04 2004-05-11 Advanced Bioprosthetic Surfaces, Ltd. Balloon catheter having metal balloon and method of making same
US6418448B1 (en) 1999-12-06 2002-07-09 Shyam Sundar Sarkar Method and apparatus for processing markup language specifications for data and metadata used inside multiple related internet documents to navigate, query and manipulate information from a plurality of object relational databases over the web
US6270522B1 (en) 1999-12-21 2001-08-07 Advanced Cardiovascular Systems, Inc. High pressure catheter balloon
US6527740B1 (en) 1999-12-22 2003-03-04 Advanced Cardiovascular Systems, Inc. Medical regrooming and drug delivery device
US7166098B1 (en) 1999-12-30 2007-01-23 Advanced Cardiovascular Systems, Inc. Medical assembly with transducer for local delivery of a therapeutic substance and method of using same
US6899731B2 (en) 1999-12-30 2005-05-31 Boston Scientific Scimed, Inc. Controlled delivery of therapeutic agents by insertable medical devices
US20020041898A1 (en) 2000-01-05 2002-04-11 Unger Evan C. Novel targeted delivery systems for bioactive agents
DE10031740A1 (en) 2000-06-29 2002-02-14 Sanguibio Tech Ag Artificial oxygen carriers from cross-linked modified human or pig hemoglobin with improved properties, processes for their technically simple production from purified material in high yields, and their use
DE10031742A1 (en) 2000-06-29 2002-01-17 Sanguibio Tech Ag Production of cross-linked hemoglobin useful as artificial oxygen carrier comprises cross-linkage of hemoglobin in presence of a chemically inert effector of the hemoglobin oxygen affinity
US6506408B1 (en) * 2000-07-13 2003-01-14 Scimed Life Systems, Inc. Implantable or insertable therapeutic agent delivery device
EP2292185B1 (en) * 2000-07-24 2013-12-04 Jeffrey Grayzel Stiffened balloon catheter for dilatation and stenting
US6451373B1 (en) 2000-08-04 2002-09-17 Advanced Cardiovascular Systems, Inc. Method of forming a therapeutic coating onto a surface of an implantable prosthesis
MXPA03001406A (en) 2000-08-15 2004-05-04 Surmodics Inc Medicament incorporation matrix.
US6602246B1 (en) 2000-08-18 2003-08-05 Cryovascular Systems, Inc. Cryotherapy method for detecting and treating vulnerable plaque
US6544221B1 (en) 2000-08-30 2003-04-08 Advanced Cardiovascular Systems, Inc. Balloon designs for drug delivery
US6585926B1 (en) 2000-08-31 2003-07-01 Advanced Cardiovascular Systems, Inc. Method of manufacturing a porous balloon
US6805898B1 (en) 2000-09-28 2004-10-19 Advanced Cardiovascular Systems, Inc. Surface features of an implantable medical device
US6863861B1 (en) 2000-09-28 2005-03-08 Boston Scientific Scimed, Inc. Process for forming a medical device balloon
US7803149B2 (en) 2002-07-12 2010-09-28 Cook Incorporated Coated medical device
JP4583756B2 (en) 2000-10-31 2010-11-17 クック インコーポレイテッド Medical instruments
US6638246B1 (en) 2000-11-28 2003-10-28 Scimed Life Systems, Inc. Medical device for delivery of a biologically active material to a lumen
DE10059151C2 (en) 2000-11-29 2003-10-16 Christoph Alexiou Magnetic particles for targeted regional therapy and use of the same
US6545097B2 (en) 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
US6623452B2 (en) 2000-12-19 2003-09-23 Scimed Life Systems, Inc. Drug delivery catheter having a highly compliant balloon with infusion holes
US6544223B1 (en) 2001-01-05 2003-04-08 Advanced Cardiovascular Systems, Inc. Balloon catheter for delivering therapeutic agents
US7179251B2 (en) * 2001-01-17 2007-02-20 Boston Scientific Scimed, Inc. Therapeutic delivery balloon
JP2002240847A (en) 2001-02-14 2002-08-28 Shiseido Co Ltd Roll-on vessel
DE10114247A1 (en) * 2001-03-22 2002-10-10 Heraeus Kulzer Gmbh & Co Kg Antibiotic / antibiotics-polymer combination
DE10115740A1 (en) 2001-03-26 2002-10-02 Ulrich Speck Preparation for restenosis prophylaxis
US6645135B1 (en) 2001-03-30 2003-11-11 Advanced Cardiovascular Systems, Inc. Intravascular catheter device and method for simultaneous local delivery of radiation and a therapeutic substance
EP1412013A2 (en) 2001-03-30 2004-04-28 Nanopass Ltd. Inflatable medical device with combination cutting elements and drug delivery conduits
US6796960B2 (en) 2001-05-04 2004-09-28 Wit Ip Corporation Low thermal resistance elastic sleeves for medical device balloons
US7018371B2 (en) 2001-05-07 2006-03-28 Xoft, Inc. Combination ionizing radiation and radiosensitizer delivery devices and methods for inhibiting hyperplasia
US7247338B2 (en) 2001-05-16 2007-07-24 Regents Of The University Of Minnesota Coating medical devices
US7862495B2 (en) 2001-05-31 2011-01-04 Advanced Cardiovascular Systems, Inc. Radiation or drug delivery source with activity gradient to minimize edge effects
US6706013B1 (en) 2001-06-29 2004-03-16 Advanced Cardiovascular Systems, Inc. Variable length drug delivery catheter
US6786900B2 (en) 2001-08-13 2004-09-07 Cryovascular Systems, Inc. Cryotherapy methods for treating vessel dissections and side branch occlusion
US20040137066A1 (en) 2001-11-26 2004-07-15 Swaminathan Jayaraman Rationally designed therapeutic intravascular implant coating
KR20030023369A (en) 2001-09-13 2003-03-19 한국과학기술연구원 Oily paclitaxel composition and formulation for chemoembolization and preparation method thereof
US7195640B2 (en) * 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US20030064965A1 (en) 2001-10-02 2003-04-03 Jacob Richter Method of delivering drugs to a tissue using drug-coated medical devices
IL161335A0 (en) 2001-10-15 2004-09-27 Hemoteq Gmbh Coating of stents for preventing restenosis
US20030077310A1 (en) 2001-10-22 2003-04-24 Chandrashekhar Pathak Stent coatings containing HMG-CoA reductase inhibitors
US7682387B2 (en) 2002-04-24 2010-03-23 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
ATE367172T1 (en) 2001-11-08 2007-08-15 Atrium Medical Corp INTRALUMINAL DEVICE HAVING A COATING CONTAINING A THERAPEUTIC AGENT
MXPA04005038A (en) 2001-11-30 2004-08-11 Bristol Myers Squibb Co Paclitaxel solvates.
US6663880B1 (en) 2001-11-30 2003-12-16 Advanced Cardiovascular Systems, Inc. Permeabilizing reagents to increase drug delivery and a method of local delivery
US6972024B1 (en) 2001-12-21 2005-12-06 Advanced Cardiovascular Systems, Inc. Method of treating vulnerable plaque
US7160317B2 (en) 2002-01-04 2007-01-09 Boston Scientific Scimed, Inc. Multiple-wing balloon catheter to reduce damage to coated expandable medical implants
US20030171734A1 (en) 2002-01-22 2003-09-11 Endobionics, Inc. Methods and kits for delivering pharmaceutical agents into the coronary vascular adventitia
US6790224B2 (en) 2002-02-04 2004-09-14 Scimed Life Systems, Inc. Medical devices
US7186237B2 (en) 2002-02-14 2007-03-06 Avantec Vascular Corporation Ballon catheter for creating a longitudinal channel in a lesion and method
US6780324B2 (en) 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
DE60327067D1 (en) 2002-04-25 2009-05-20 Univ R EXPANDABLE GUIDE SLEEVE
US7008979B2 (en) 2002-04-30 2006-03-07 Hydromer, Inc. Coating composition for multiple hydrophilic applications
US7709048B2 (en) 2002-05-02 2010-05-04 Labcoat, Ltd. Method and apparatus for coating a medical device
US7048962B2 (en) 2002-05-02 2006-05-23 Labcoat, Ltd. Stent coating device
US6645547B1 (en) 2002-05-02 2003-11-11 Labcoat Ltd. Stent coating device
CA2484374C (en) 2002-05-09 2011-05-17 Hemoteq Gmbh Medical products comprising a haemocompatible coating, production and use thereof
US6960346B2 (en) 2002-05-09 2005-11-01 University Of Tennessee Research Foundation Vehicles for delivery of biologically active substances
US7105175B2 (en) 2002-06-19 2006-09-12 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US20030236513A1 (en) 2002-06-19 2003-12-25 Scimed Life Systems, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US8211455B2 (en) 2002-06-19 2012-07-03 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US20060204537A1 (en) 2002-06-21 2006-09-14 Genzyme Corporation Silicone blends and composites for drug delivery
US7335184B2 (en) * 2002-07-02 2008-02-26 Sentient Engineering And Technology Balloon catheter and treatment apparatus
US20040034336A1 (en) * 2002-08-08 2004-02-19 Neal Scott Charged liposomes/micelles with encapsulted medical compounds
WO2004014449A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery system including a polyurethane, medical device, and method
US20040039437A1 (en) * 2002-08-13 2004-02-26 Medtronic, Inc. Medical device exhibiting improved adhesion between polymeric coating and substrate
EP1539265B1 (en) 2002-08-13 2007-09-26 Medtronic, Inc. Active agent delivery system including a hydrophobic cellulose derivate
US20040127978A1 (en) 2002-08-13 2004-07-01 Medtronic, Inc. Active agent delivery system including a hydrophilic polymer, medical device, and method
DE60331552D1 (en) 2002-08-13 2010-04-15 Medtronic Inc PHARMACEUTICALS COMPOSITIONS USING POLY (ETHYLENE-CO (METH) ACRYLATE, MEDICAL DEVICE AND METHOD
JP2006502135A (en) 2002-08-13 2006-01-19 メドトロニック・インコーポレーテッド Active drug delivery system, medical device and method
US6991617B2 (en) 2002-08-21 2006-01-31 Hektner Thomas R Vascular treatment method and device
US20040044404A1 (en) 2002-08-30 2004-03-04 Stucke Sean M. Retention coatings for delivery systems
WO2004022124A1 (en) 2002-09-06 2004-03-18 Abbott Laboratories Medical device having hydration inhibitor
JP2006501887A (en) 2002-09-13 2006-01-19 ザ ユニバーシティ オブ ブリティッシュ コロンビア Implantable medical device coated with calcium phosphate and method of manufacturing the same
DE10244847A1 (en) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medical device for drug delivery
US7060051B2 (en) 2002-09-24 2006-06-13 Scimed Life Systems, Inc. Multi-balloon catheter with hydrogel coating
US6971813B2 (en) 2002-09-27 2005-12-06 Labcoat, Ltd. Contact coating of prostheses
US7037319B2 (en) 2002-10-15 2006-05-02 Scimed Life Systems, Inc. Nanotube paper-based medical device
US7459169B2 (en) 2002-10-21 2008-12-02 Allvivo, Inc. Surface coating comprising bioactive compound
US7048714B2 (en) 2002-10-30 2006-05-23 Biorest Ltd. Drug eluting medical device with an expandable portion for drug release
US20060121080A1 (en) 2002-11-13 2006-06-08 Lye Whye K Medical devices having nanoporous layers and methods for making the same
DE10253634A1 (en) 2002-11-13 2004-05-27 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin endoprosthesis
US7491234B2 (en) 2002-12-03 2009-02-17 Boston Scientific Scimed, Inc. Medical devices for delivery of therapeutic agents
US20040111144A1 (en) 2002-12-06 2004-06-10 Lawin Laurie R. Barriers for polymeric coatings
US20040117222A1 (en) 2002-12-14 2004-06-17 International Business Machines Corporation System and method for evaluating information aggregates by generation of knowledge capital
US20060002968A1 (en) * 2004-06-30 2006-01-05 Gordon Stewart Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders
ATE457716T1 (en) 2002-12-30 2010-03-15 Angiotech Int Ag RELEASE OF ACTIVE INGREDIENTS FROM QUICK-GELLING POLYMER COMPOSITION
WO2004060405A2 (en) 2002-12-30 2004-07-22 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
AU2003300202A1 (en) 2003-01-02 2004-07-29 Novoste Corporation Drug delivery balloon catheter
US7494497B2 (en) * 2003-01-02 2009-02-24 Boston Scientific Scimed, Inc. Medical devices
US7686824B2 (en) 2003-01-21 2010-03-30 Angioscore, Inc. Apparatus and methods for treating hardened vascular lesions
EP1610752B1 (en) 2003-01-31 2013-01-02 Boston Scientific Limited Localized drug delivery using drug-loaded nanocapsules and implantable device coated with the same
US20040224003A1 (en) 2003-02-07 2004-11-11 Schultz Robert K. Drug formulations for coating medical devices
US8313759B2 (en) 2003-03-06 2012-11-20 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing miscible polymer blends for controlled delivery of a therapeutic agent
US8281737B2 (en) 2003-03-10 2012-10-09 Boston Scientific Scimed, Inc. Coated medical device and method for manufacturing the same
KR20050114262A (en) 2003-03-31 2005-12-05 테바 기오기스제르갸르 레스즈베니타르사사그 Crystallization and purification of macrolides
US7241455B2 (en) 2003-04-08 2007-07-10 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent
DE10318803B4 (en) 2003-04-17 2005-07-28 Translumina Gmbh Device for applying active substances to surfaces of medical implants, in particular stents
US20040230176A1 (en) 2003-04-23 2004-11-18 Medtronic Vascular, Inc. System for treating a vascular condition that inhibits restenosis at stent ends
US7279002B2 (en) 2003-04-25 2007-10-09 Boston Scientific Scimed, Inc. Cutting stent and balloon
US7288084B2 (en) 2003-04-28 2007-10-30 Boston Scientific Scimed, Inc. Drug-loaded medical device
US7473242B2 (en) * 2003-04-30 2009-01-06 Medtronic Vascular, Inc. Method and systems for treating vulnerable plaque
US6923996B2 (en) 2003-05-06 2005-08-02 Scimed Life Systems, Inc. Processes for producing polymer coatings for release of therapeutic agent
US7632288B2 (en) 2003-05-12 2009-12-15 Boston Scientific Scimed, Inc. Cutting balloon catheter with improved pushability
US7060062B2 (en) 2003-06-04 2006-06-13 Cryo Vascular Systems, Inc. Controllable pressure cryogenic balloon treatment system and method
JP2005022590A (en) * 2003-07-01 2005-01-27 Nissan Motor Co Ltd Display unit for vehicle
US8025637B2 (en) * 2003-07-18 2011-09-27 Boston Scientific Scimed, Inc. Medical balloons and processes for preparing same
US20050025848A1 (en) * 2003-07-30 2005-02-03 Ruey-Fa Huang Air filter shaping mold
US9114199B2 (en) * 2003-07-31 2015-08-25 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing acrylic copolymer for controlled delivery of therapeutic agent
US7357940B2 (en) * 2003-07-31 2008-04-15 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents
US8870814B2 (en) * 2003-07-31 2014-10-28 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing silicone copolymer for controlled delivery of therapeutic agent
US7914805B2 (en) * 2003-07-31 2011-03-29 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing radiation-treated polymer for improved delivery of therapeutic agent
WO2005011561A2 (en) 2003-08-04 2005-02-10 Labcoat, Ltd. Stent coating apparatus and method
US20050037048A1 (en) * 2003-08-11 2005-02-17 Young-Ho Song Medical devices containing antioxidant and therapeutic agent
US7364585B2 (en) * 2003-08-11 2008-04-29 Boston Scientific Scimed, Inc. Medical devices comprising drug-loaded capsules for localized drug delivery
JP2007502281A (en) 2003-08-13 2007-02-08 メドトロニック・インコーポレーテッド Active agent release system, medical device and method comprising a miscible polymer formulation
JP2008511339A (en) 2003-08-13 2008-04-17 メドトロニック・インコーポレーテッド Active drug delivery system, medical device and method comprising monolayers of compatible polymer blends
US8740844B2 (en) * 2003-08-20 2014-06-03 Boston Scientific Scimed, Inc. Medical device with drug delivery member
US20050048194A1 (en) 2003-09-02 2005-03-03 Labcoat Ltd. Prosthesis coating decision support system
US20050055077A1 (en) 2003-09-05 2005-03-10 Doron Marco Very low profile medical device system having an adjustable balloon
US20050113687A1 (en) 2003-09-15 2005-05-26 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using a porous medical device
US8021331B2 (en) 2003-09-15 2011-09-20 Atrium Medical Corporation Method of coating a folded medical device
DE102004020856A1 (en) 2003-09-29 2005-04-14 Hemoteq Gmbh Medical product coated with biostable layer of polysulfone, useful particularly as stent for preventing restenosis, controls kinetics of release of incorporated active agents, e.g. antiproliferative agents
BRPI0414849B1 (en) 2003-09-29 2017-05-16 Hemoteq Ag medicinal product and biocompatible coating method of medicinal products
ATE475448T1 (en) 2003-10-03 2010-08-15 Medtronic Inc EXPANDABLE GUIDE LOCK AND DEVICE
US20070207179A1 (en) 2003-10-14 2007-09-06 Erik Andersen Medical Device
US20050129731A1 (en) 2003-11-03 2005-06-16 Roland Horres Biocompatible, biostable coating of medical surfaces
EP1535952B1 (en) 2003-11-28 2013-01-16 Universite Louis Pasteur Method for preparing crosslinked polyelectrolyte multilayer films
US20060286141A1 (en) 2003-12-15 2006-12-21 Campbell Todd D Systems for gel-based medical implants
US7771447B2 (en) 2003-12-19 2010-08-10 Boston Scientific Scimed, Inc. Balloon refolding device
US7563324B1 (en) 2003-12-29 2009-07-21 Advanced Cardiovascular Systems Inc. System and method for coating an implantable medical device
US7407684B2 (en) 2004-01-28 2008-08-05 Boston Scientific Scimed, Inc. Multi-step method of manufacturing a medical device
US20050181015A1 (en) 2004-02-12 2005-08-18 Sheng-Ping (Samuel) Zhong Layered silicate nanoparticles for controlled delivery of therapeutic agents from medical articles
DE112005001005A5 (en) 2004-02-28 2007-05-24 Hemoteq Gmbh Biocompatible coating, process and use of medical surfaces
EP2279736A1 (en) 2004-03-12 2011-02-02 Life Science Investments Ltd. Microbicidal and antiparasitic compositions comprising quassinoids or quassionid-containing plant extracts
ATE534424T1 (en) 2004-03-19 2011-12-15 Abbott Lab MULTIPLE MEDICINAL DELIVERY FROM A BALLOON AND A PROSTHESIS
US20050209548A1 (en) 2004-03-19 2005-09-22 Dev Sukhendu B Electroporation-mediated intravascular delivery
US20070027523A1 (en) * 2004-03-19 2007-02-01 Toner John L Method of treating vascular disease at a bifurcated vessel using coated balloon
US7744644B2 (en) 2004-03-19 2010-06-29 Boston Scientific Scimed, Inc. Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release
US20100030183A1 (en) * 2004-03-19 2010-02-04 Toner John L Method of treating vascular disease at a bifurcated vessel using a coated balloon
US8431145B2 (en) * 2004-03-19 2013-04-30 Abbott Laboratories Multiple drug delivery from a balloon and a prosthesis
US9555223B2 (en) 2004-03-23 2017-01-31 Medtronic Cryocath Lp Method and apparatus for inflating and deflating balloon catheters
US8003122B2 (en) 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
US20050220853A1 (en) 2004-04-02 2005-10-06 Kinh-Luan Dao Controlled delivery of therapeutic agents from medical articles
CN1964748A (en) 2004-04-06 2007-05-16 苏莫迪克斯公司 Coating compositions for bioactive agents
US20050226991A1 (en) 2004-04-07 2005-10-13 Hossainy Syed F Methods for modifying balloon of a catheter assembly
US7371424B2 (en) 2004-04-14 2008-05-13 Boston Scientific Scimed, Inc. Method and apparatus for coating a medical device using a coating head
WO2005118020A1 (en) 2004-04-21 2005-12-15 Allvivo, Inc. Surface coating comprising bioactive compound
JP2007534389A (en) 2004-04-29 2007-11-29 キューブ・メディカル・アクティーゼルスカブ Balloon used for angiogenesis
US7070576B2 (en) 2004-04-30 2006-07-04 Boston Scientific Scimed, Inc. Directional cutting balloon
US20060240065A1 (en) * 2005-04-26 2006-10-26 Yung-Ming Chen Compositions for medical devices containing agent combinations in controlled volumes
US7753876B2 (en) 2004-05-10 2010-07-13 Medtronic Vascular, Inc. Expandable jaw drug delivery catheter
US7758892B1 (en) 2004-05-20 2010-07-20 Boston Scientific Scimed, Inc. Medical devices having multiple layers
US20050273075A1 (en) 2004-06-08 2005-12-08 Peter Krulevitch Method for delivering drugs to the adventitia using device having microprojections
US20050273049A1 (en) 2004-06-08 2005-12-08 Peter Krulevitch Drug delivery device using microprojections
US7976557B2 (en) 2004-06-23 2011-07-12 Boston Scientific Scimed, Inc. Cutting balloon and process
EP1773439A4 (en) 2004-07-14 2010-01-20 By Pass Inc Material delivery system
US20060013853A1 (en) * 2004-07-19 2006-01-19 Richard Robert E Medical devices having conductive substrate and covalently bonded coating layer
US7771740B2 (en) * 2004-07-19 2010-08-10 Boston Scientific Scimed, Inc. Medical devices containing copolymers with graft copolymer endblocks for drug delivery
US20060025848A1 (en) * 2004-07-29 2006-02-02 Jan Weber Medical device having a coating layer with structural elements therein and method of making the same
US7758541B2 (en) * 2004-08-17 2010-07-20 Boston Scientific Scimed, Inc. Targeted drug delivery device and method
US20070292478A1 (en) 2004-08-30 2007-12-20 Popowski Youri Medical Implant Provided with Inhibitors of Atp Synthesis
US20060051390A1 (en) 2004-09-03 2006-03-09 Schwarz Marlene C Medical devices having self-forming rate-controlling barrier for drug release
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US7470252B2 (en) 2004-09-16 2008-12-30 Boston Scientific Scimed, Inc. Expandable multi-port therapeutic delivery system
US8361490B2 (en) 2004-09-16 2013-01-29 Theracoat Ltd. Biocompatible drug delivery apparatus and methods
US8312836B2 (en) * 2004-09-28 2012-11-20 Atrium Medical Corporation Method and apparatus for application of a fresh coating on a medical device
WO2006036970A2 (en) 2004-09-28 2006-04-06 Atrium Medical Corporation Method of thickening a coating using a drug
WO2006036967A1 (en) 2004-09-28 2006-04-06 Atrium Medical Corporation Solubilizing a drug for use in a coating
US20060069385A1 (en) 2004-09-28 2006-03-30 Scimed Life Systems, Inc. Methods and apparatus for tissue cryotherapy
CN101076319A (en) 2004-09-29 2007-11-21 科迪斯公司 Pharmaceutical dosage forms of stable amorphous rapamycin like compounds
US7491188B2 (en) * 2004-10-12 2009-02-17 Boston Scientific Scimed, Inc. Reinforced and drug-eluting balloon catheters and methods for making same
US7402172B2 (en) 2004-10-13 2008-07-22 Boston Scientific Scimed, Inc. Intraluminal therapeutic patch
US20060085058A1 (en) 2004-10-20 2006-04-20 Rosenthal Arthur L System and method for delivering a biologically active material to a body lumen
US20060088566A1 (en) 2004-10-27 2006-04-27 Scimed Life Systems, Inc.,A Corporation Method of controlling drug release from a coated medical device through the use of nucleating agents
US7588642B1 (en) 2004-11-29 2009-09-15 Advanced Cardiovascular Systems, Inc. Abluminal stent coating apparatus and method using a brush assembly
CA2584360A1 (en) 2004-12-01 2006-06-08 Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag Processes for producing crystalline macrolides
US7658744B2 (en) 2004-12-03 2010-02-09 Boston Scientific Scimed, Inc. Multiple balloon catheter
US20060134168A1 (en) 2004-12-07 2006-06-22 Chappa Ralph A Coatings with crystallized active agent(s) and methods
US7604631B2 (en) 2004-12-15 2009-10-20 Boston Scientific Scimed, Inc. Efficient controlled cryogenic fluid delivery into a balloon catheter and other treatment devices
US7698270B2 (en) * 2004-12-29 2010-04-13 Baynote, Inc. Method and apparatus for identifying, extracting, capturing, and leveraging expertise and knowledge
US7303572B2 (en) 2004-12-30 2007-12-04 Cook Incorporated Catheter assembly with plaque cutting balloon
US20060147491A1 (en) 2005-01-05 2006-07-06 Dewitt David M Biodegradable coating compositions including multiple layers
US7988987B2 (en) 2005-01-25 2011-08-02 Boston Scientific Scimed, Inc. Medical devices containing crazed polymeric release regions for drug delivery
US8202245B2 (en) 2005-01-26 2012-06-19 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US7749553B2 (en) 2005-01-31 2010-07-06 Boston Scientific Scimed, Inc. Method and system for coating a medical device using optical drop volume verification
US8535702B2 (en) 2005-02-01 2013-09-17 Boston Scientific Scimed, Inc. Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
US8221824B2 (en) 2005-02-03 2012-07-17 Boston Scientific Scimed, Inc. Deforming surface of drug eluting coating to alter drug release profile of a medical device
US20060184191A1 (en) 2005-02-11 2006-08-17 Boston Scientific Scimed, Inc. Cutting balloon catheter having increased flexibility regions
US20100331947A1 (en) 2005-02-17 2010-12-30 Alon Shalev Inflatable Medical Device
US8048028B2 (en) 2005-02-17 2011-11-01 Boston Scientific Scimed, Inc. Reinforced medical balloon
US20060193891A1 (en) 2005-02-25 2006-08-31 Robert Richard Medical devices and therapeutic delivery devices composed of bioabsorbable polymers produced at room temperature, method of making the devices, and a system for making the devices
US20060200048A1 (en) 2005-03-03 2006-09-07 Icon Medical Corp. Removable sheath for device protection
US7527604B2 (en) 2005-03-09 2009-05-05 Boston Scientific Scimed, Inc. Rotatable multi-port therapeutic delivery device
US20060212106A1 (en) 2005-03-21 2006-09-21 Jan Weber Coatings for use on medical devices
EP2327429B1 (en) 2005-03-23 2014-09-17 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US7998195B2 (en) 2005-03-25 2011-08-16 Boston Scientific Scimed, Inc. Device with engineered surface architecture coating for controlled drug release
US20060224115A1 (en) 2005-03-30 2006-10-05 Boston Scientific Scimed, Inc. Balloon catheter with expandable wire lumen
WO2006108420A1 (en) 2005-04-12 2006-10-19 Millimed A/S Inflatable medical device comprising a permeable membrane
KR20080008364A (en) 2005-05-05 2008-01-23 헤모텍 아게 All-over coating of vessel stents
US8460357B2 (en) 2005-05-31 2013-06-11 J.W. Medical Systems Ltd. In situ stent formation
CN1317920C (en) * 2005-06-15 2007-05-23 华为技术有限公司 Service indication message transmitting method under sleeping mode
US20060286071A1 (en) 2005-06-21 2006-12-21 Epstein Samuel J Therapeutic pastes for medical device coating
CA2615452C (en) 2005-07-15 2015-03-31 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
US8722074B2 (en) * 2005-07-19 2014-05-13 Boston Scientific Scimed, Inc. Medical devices containing radiation resistant polymers
US20070078413A1 (en) 2005-08-25 2007-04-05 Stenzel Eric B Medical device having a lubricant
US7599727B2 (en) 2005-09-15 2009-10-06 Labcoat, Ltd. Lighting and imaging system including a flat light source with LED illumination
US20070067882A1 (en) 2005-09-21 2007-03-22 Liliana Atanasoska Internal medical devices having polyelectrolyte-containing extruded regions
US7342670B2 (en) 2005-10-19 2008-03-11 Labcoat, Ltd. In-flight drop location verification system
US9440003B2 (en) 2005-11-04 2016-09-13 Boston Scientific Scimed, Inc. Medical devices having particle-containing regions with diamond-like coatings
US8051797B1 (en) 2005-11-07 2011-11-08 Boston Scientific Scimed, Inc. Device to stabilize and align a pre-mounted stent
US8137735B2 (en) 2005-11-10 2012-03-20 Allegiance Corporation Elastomeric article with antimicrobial coating
JP5153340B2 (en) 2005-11-16 2013-02-27 学校法人東海大学 Drug release control composition and drug release medical device
US7795326B2 (en) 2005-12-07 2010-09-14 Rochal Industries, Llp Conformable bandage and coating material
US7580930B2 (en) 2005-12-27 2009-08-25 Baynote, Inc. Method and apparatus for predicting destinations in a navigation context based upon observed usage patterns
KR100673023B1 (en) 2005-12-28 2007-01-24 삼성전자주식회사 Semiconductor memory device using pipelined-buffer programming scheme
US7842312B2 (en) 2005-12-29 2010-11-30 Cordis Corporation Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same
US7919108B2 (en) 2006-03-10 2011-04-05 Cook Incorporated Taxane coatings for implantable medical devices
US20090276036A1 (en) 2006-01-23 2009-11-05 Terumo Kabushiki Kaisha Stent
US8431060B2 (en) 2006-01-31 2013-04-30 Abbott Cardiovascular Systems Inc. Method of fabricating an implantable medical device using gel extrusion and charge induced orientation
US8440214B2 (en) 2006-01-31 2013-05-14 Boston Scientific Scimed, Inc. Medical devices for therapeutic agent delivery with polymeric regions that contain copolymers having both soft segments and uniform length hard segments
JP5508720B2 (en) * 2006-02-07 2014-06-04 テファ， インコーポレイテッド Polymer degradable drug eluting stent and coating
US8287940B2 (en) 2006-02-09 2012-10-16 B. Braun Melsungen Ag Coating method for a folded balloon
CN101379578B (en) 2006-02-10 2012-07-18 马夸特有限责任公司 Electric switch comprising sealing connection
US7718213B1 (en) 2006-02-24 2010-05-18 Ingo Werner Scheer Holding device and method for coating a substrate
US20070244548A1 (en) 2006-02-27 2007-10-18 Cook Incorporated Sugar-and drug-coated medical device
EP1832289A3 (en) 2006-03-08 2007-12-12 Sahajanand Medical Technologies PVT. ltd Compositions and coatings for implantable medical devices
US7875284B2 (en) 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
KR20080100415A (en) 2006-03-17 2008-11-18 트라이엄프,오퍼레이팅애즈어조인트벤쳐바이더거버너스 오브더유니버시티오브알버타더유니버시티오브브리티시콜롬비아 칼레톤유니버시티시몬프레이저유니버시티더유니버시티 오브토론토앤드더유니버시티오브빅토리아 Self-supporting multilayer films having a diamond-like carbon layer
US20070224234A1 (en) 2006-03-22 2007-09-27 Mark Steckel Medical devices having biodegradable polymeric regions
US20070225800A1 (en) 2006-03-24 2007-09-27 Sahatjian Ronald A Methods and devices having electrically actuatable surfaces
US8518105B2 (en) * 2006-03-24 2013-08-27 Abbott Cardiovascular System Inc. Methods and apparatuses for coating a lesion
ATE519511T1 (en) 2006-06-30 2011-08-15 Cook Inc METHOD FOR PRODUCING AND MODIFYING TAXAN COATINGS FOR IMPLANTABLE MEDICAL DEVICES
KR20090045916A (en) 2006-07-03 2009-05-08 헤모텍 아게 Manufacture, method and use of drug-eluting medical devices for permanently keeping blood vessels open
US7820812B2 (en) 2006-07-25 2010-10-26 Abbott Laboratories Methods of manufacturing crystalline forms of rapamycin analogs
EP2407471A3 (en) 2006-07-25 2012-06-20 Abbott Laboratories Process for preparing a crystalline form of rapamycin analogs
US20080027421A1 (en) * 2006-07-27 2008-01-31 Vancelette David W CryoBalloon Treatment for Postpartum Hemorrhage
US20080057102A1 (en) 2006-08-21 2008-03-06 Wouter Roorda Methods of manufacturing medical devices for controlled drug release
US7897170B2 (en) * 2006-08-25 2011-03-01 Boston Scientific Scimed, Inc. Medical devices having improved mechanical performance
US20080050415A1 (en) * 2006-08-25 2008-02-28 Boston Scientic Scimed, Inc. Polymeric/ceramic composite materials for use in medical devices
US20100004593A1 (en) 2006-09-13 2010-01-07 Boston Scientific Scimed, Inc. Balloon catheter
WO2008036548A2 (en) 2006-09-18 2008-03-27 Boston Scientific Limited Endoprostheses
WO2008036554A2 (en) 2006-09-18 2008-03-27 Boston Scientific Limited Endoprostheses
US7666179B2 (en) 2006-10-10 2010-02-23 Boston Scientific Scimed, Inc. Medical devices having porous regions for controlled therapeutic agent exposure or delivery
US20080095847A1 (en) 2006-10-18 2008-04-24 Thierry Glauser Stimulus-release carrier, methods of manufacture and methods of treatment
JP4191219B2 (en) 2006-10-30 2008-12-03 エルピーダメモリ株式会社 Memory circuit, semiconductor device, and control method of memory circuit
US8153181B2 (en) 2006-11-14 2012-04-10 Boston Scientific Scimed, Inc. Medical devices and related methods
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8430055B2 (en) 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US20080175887A1 (en) 2006-11-20 2008-07-24 Lixiao Wang Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US20080140002A1 (en) 2006-12-06 2008-06-12 Kamal Ramzipoor System for delivery of biologically active substances with actuating three dimensional surface
US7641844B2 (en) 2006-12-11 2010-01-05 Cook Incorporated Method of making a fiber-reinforced medical balloon
EP2101779A1 (en) 2006-12-13 2009-09-23 Angiotech Pharmaceuticals, Inc. Medical implants with a combination of compounds
US20080171129A1 (en) 2007-01-16 2008-07-17 Cappella, Inc. Drug eluting medical device using polymeric therapeutics with patterned coating
RU2447901C2 (en) 2007-01-21 2012-04-20 Хемотек Аг Medical device for treating lumen obturations and preventing threatening recurrent obturations
DE102007003184A1 (en) 2007-01-22 2008-07-24 Orlowski, Michael, Dr. Method for loading structured surfaces
WO2008097511A2 (en) 2007-02-07 2008-08-14 Cook Incorporated Medical device coatings for releasing a therapeutic agent at multiple rates
DE102007008479A1 (en) 2007-02-21 2008-09-04 Orlowski, Michael, Dr. Coated Expandable System
US7887830B2 (en) 2007-02-27 2011-02-15 Boston Scientific Scimed, Inc. Medical devices having polymeric regions based on styrene-isobutylene copolymers
US7914807B2 (en) 2007-03-05 2011-03-29 Boston Scientific Scimed, Inc. Medical devices having improved performance
EP2114507A1 (en) 2007-03-06 2009-11-11 Cook Incorporated Therapeutic agent delivery system
US7896840B2 (en) 2007-04-05 2011-03-01 Boston Scientific Scimed, Inc. Catheter having internal mechanisms to encourage balloon re-folding
GR20070100224A (en) 2007-04-13 2008-11-14 Κωνστατινος Σπαργιας Anti-restenosis drug covered and eluting baloon for valvuloplasty of aortic valve stenosis for the prevention of restenosis.
US20080268018A1 (en) 2007-04-30 2008-10-30 Pacetti Stephen D Method for forming crystallized therapeutic agents on a medical device
US20080287984A1 (en) 2007-05-18 2008-11-20 Jan Weber Medical balloons and methods of making the same
JP2010530788A (en) 2007-06-22 2010-09-16 アイコン メディカル コーポレーション Heatable induction device
US9370642B2 (en) 2007-06-29 2016-06-21 J.W. Medical Systems Ltd. Adjustable-length drug delivery balloon
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US8617114B2 (en) 2007-07-13 2013-12-31 Abbott Cardiovascular Systems Inc. Drug coated balloon catheter
US8690823B2 (en) * 2007-07-13 2014-04-08 Abbott Cardiovascular Systems Inc. Drug coated balloon catheter
US8070798B2 (en) * 2007-07-20 2011-12-06 Josiah Wilcox Drug eluting medical device and method
US20090157172A1 (en) 2007-07-24 2009-06-18 Boston Scientific Scrimed, Inc. Stents with polymer-free coatings for delivering a therapeutic agent
DE102007036685A1 (en) 2007-08-03 2009-02-05 Innora Gmbh Improved drug-coated medical devices their manufacture and use
DE102007040868A1 (en) 2007-08-29 2009-04-16 Innora Gmbh Balloon catheter with protection against unfolding
US8221783B2 (en) 2007-09-10 2012-07-17 Boston Scientific Scimed, Inc. Medical devices with triggerable bioadhesive material
US8211055B2 (en) 2007-09-12 2012-07-03 Cook Medical Technologies Llc Drug eluting balloon
EP2195068B1 (en) 2007-09-12 2017-07-26 Cook Medical Technologies LLC Balloon catheter for delivering a therapeutic agent
US8100855B2 (en) 2007-09-17 2012-01-24 Abbott Cardiovascular Systems, Inc. Methods and devices for eluting agents to a vessel
US20090105687A1 (en) 2007-10-05 2009-04-23 Angioscore, Inc. Scoring catheter with drug delivery membrane
US7863387B2 (en) 2007-10-25 2011-01-04 Boston Scientific Scimed, Inc. Dehydrofluorination and surface modification of fluoropolymers for drug delivery applications
US20090112239A1 (en) 2007-10-31 2009-04-30 Specialized Vascular Technologies, Inc. Sticky dilatation balloon and methods of using
AU2007361589B9 (en) 2007-11-21 2014-05-08 Invatec S.P.A. Balloon for the treatment of stenosis and method for manufacturing the balloon
EP2249900A4 (en) 2008-02-08 2013-11-06 Terumo Corp Device for local intraluminal transport of a biologically and physiologically active agent
DE102008008925A1 (en) 2008-02-13 2009-08-20 Biotronik Vi Patent Ag Catheter, intraluminal endoprosthesis delivery system, and method of making the same
WO2009111608A1 (en) 2008-03-06 2009-09-11 Boston Scientific Scimed, Inc. Triggered drug release
WO2009111716A1 (en) 2008-03-06 2009-09-11 Boston Scientific Scimed, Inc. Balloon catheter devices with sheath covering
US9186439B2 (en) 2008-03-12 2015-11-17 Anges Mg, Inc. Drug-eluting catheter and method of manufacturing the same
JP5667559B2 (en) 2008-03-28 2015-02-12 サーモディクス，インコーポレイティド Insertable medical device having an elastic matrix with microparticles disposed thereon, and drug delivery method
US8420110B2 (en) 2008-03-31 2013-04-16 Cordis Corporation Drug coated expandable devices
US8409601B2 (en) 2008-03-31 2013-04-02 Cordis Corporation Rapamycin coated expandable devices
EP2106820A1 (en) 2008-03-31 2009-10-07 Torsten Heilmann Expansible biocompatible coats comprising a biologically active substance
US9114125B2 (en) 2008-04-11 2015-08-25 Celonova Biosciences, Inc. Drug eluting expandable devices
WO2009135125A2 (en) 2008-05-01 2009-11-05 Bayer Schering Pharma Ag Catheter balloon drug adherence techniques and methods
US8128617B2 (en) 2008-05-27 2012-03-06 Boston Scientific Scimed, Inc. Electrical mapping and cryo ablating with a balloon catheter
US8187261B2 (en) 2008-05-29 2012-05-29 Boston Scientific Scimed, Inc. Regulating internal pressure of a cryotherapy balloon catheter
EP3566680A3 (en) * 2008-06-04 2020-02-26 W.L. Gore & Associates, Inc. Controlled deployable medical device
EP2326305A1 (en) 2008-06-20 2011-06-01 Boston Scientific Scimed, Inc. Medical devices employing conductive polymers for delivery of therapeutic agents
US8187221B2 (en) * 2008-07-11 2012-05-29 Nexeon Medsystems, Inc. Nanotube-reinforced balloons for delivering therapeutic agents within or beyond the wall of blood vessels, and methods of making and using same
JP2011528275A (en) * 2008-07-17 2011-11-17 ミセル テクノロジーズ，インク． Drug delivery medical device
US7774125B2 (en) * 2008-08-06 2010-08-10 Fluid Control Products, Inc. Programmable fuel pump control
US8642063B2 (en) 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US8133199B2 (en) 2008-08-27 2012-03-13 Boston Scientific Scimed, Inc. Electroactive polymer activation system for a medical device
US20110160575A1 (en) 2008-09-02 2011-06-30 By-Pass, Inc. Microporous balloon catheter
WO2010030728A2 (en) 2008-09-12 2010-03-18 Boston Scientific Scimed, Inc. Devices and systems for delivery of therapeutic agents to body lumens
US8128951B2 (en) 2008-09-15 2012-03-06 Cv Ingenuity Corp. Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
EP2172242A1 (en) 2008-10-03 2010-04-07 National University of Ireland Galway Intravascular Treatment Device
US20100087783A1 (en) 2008-10-07 2010-04-08 Boston Scientific Scimed, Inc. Medical devices for delivery of therapeutic agents to body lumens
US20100131043A1 (en) 2008-11-26 2010-05-27 Casas Jesus W Endoluminal Implants For Bioactive Material Delivery
WO2010080575A2 (en) 2008-12-18 2010-07-15 Michal Konstantino Method and apparatus for transport of substances into body tissue
IT1394522B1 (en) 2009-01-09 2012-07-05 Invatec Technology Ct Gmbh MEDICAL DEVICE WITH DRUG RELEASE
WO2010086863A2 (en) 2009-02-02 2010-08-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Crystalline drug-containing coatings
US8734829B2 (en) 2009-02-13 2014-05-27 Boston Scientific Scimed, Inc. Medical devices having polymeric nanoporous coatings for controlled therapeutic agent delivery and a nonpolymeric macroporous protective layer
US20100228333A1 (en) 2009-03-04 2010-09-09 William Joseph Drasler Drug eluting surface covering
US20100233228A1 (en) 2009-03-12 2010-09-16 Invatec Technology Center Gmbh Drug-Eluting Medical Device
US20100239635A1 (en) 2009-03-23 2010-09-23 Micell Technologies, Inc. Drug delivery medical device
US20100249702A1 (en) 2009-03-24 2010-09-30 Abbott Cardiovascular Systems Inc. Porous catheter balloon and method of making same
CN102481195B (en) 2009-04-01 2015-03-25 米歇尔技术公司 Drug delivery medical device
US20100261662A1 (en) 2009-04-09 2010-10-14 Endologix, Inc. Utilization of mural thrombus for local drug delivery into vascular tissue
WO2010120620A1 (en) 2009-04-13 2010-10-21 Cook Incorporated Coated balloon catheter
WO2010121187A2 (en) 2009-04-17 2010-10-21 Micell Techologies, Inc. Stents having controlled elution
US20100268191A1 (en) 2009-04-21 2010-10-21 Medtronic Vascular, Inc. Drug Delivery Catheter using Frangible Microcapsules and Delivery Method
WO2010124098A2 (en) 2009-04-24 2010-10-28 Boston Scientific Scimed, Inc. Use of drug polymorphs to achieve controlled drug delivery from a coated medical device
US20100285085A1 (en) 2009-05-07 2010-11-11 Abbott Cardiovascular Systems Inc. Balloon coating with drug transfer control via coating thickness
US20100292641A1 (en) 2009-05-15 2010-11-18 Bandula Wijay Targeted drug delivery device and method
EP2432513A2 (en) 2009-05-21 2012-03-28 Boston Scientific Scimed, Inc. Implantable medical devices for therapeutic agent delivery
EP2258439B1 (en) 2009-06-04 2020-04-29 Biotronik Ag Structured drug-eluting balloon catheter
US8591494B2 (en) 2009-06-10 2013-11-26 Boston Scientific Scimed, Inc. Electrochemical therapeutic agent delivery device
US20100324645A1 (en) 2009-06-17 2010-12-23 John Stankus Drug coated balloon catheter and pharmacokinetic profile
AU2010261804A1 (en) * 2009-06-17 2012-01-12 Dot Gmbh Method and device for coating catheters or balloon catheters
EP3064230B1 (en) * 2009-07-10 2019-04-10 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
EP2453834A4 (en) 2009-07-16 2014-04-16 Micell Technologies Inc Drug delivery medical device
EP2453938B1 (en) * 2009-07-17 2015-08-19 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US20110117266A1 (en) 2009-07-20 2011-05-19 Boston Scientific Scimed, Inc. Medical Device Coating System
US8424498B2 (en) * 2009-07-23 2013-04-23 Briggs & Stratton Corporation Engine blower scroll
WO2011028419A1 (en) 2009-08-27 2011-03-10 Boston Scientific Scimed, Inc. Balloon catheter devices with drug-coated sheath
US8617136B2 (en) 2009-08-31 2013-12-31 Boston Scientific Scimed, Inc. Balloon catheter devices with drug delivery extensions
US20110087191A1 (en) 2009-10-14 2011-04-14 Boston Scientific Scimed, Inc. Balloon catheter with shape memory sheath for delivery of therapeutic agent
US8366661B2 (en) 2009-12-18 2013-02-05 Boston Scientific Scimed, Inc. Medical device with expandable body for drug delivery by capsules
EP2519269A1 (en) 2009-12-30 2012-11-07 Boston Scientific Scimed, Inc. Drug-delivery balloons
US20110160645A1 (en) 2009-12-31 2011-06-30 Boston Scientific Scimed, Inc. Cryo Activated Drug Delivery and Cutting Balloons
WO2011091100A1 (en) 2010-01-21 2011-07-28 Boston Scientific Scimed, Inc. Balloon catheters with therapeutic agent in balloon folds and methods of making the same
US11369498B2 (en) 2010-02-02 2022-06-28 MT Acquisition Holdings LLC Stent and stent delivery system with improved deliverability
US9227041B2 (en) 2010-04-09 2016-01-05 Boston Scientific Scimed, Inc. Balloon catheters with fibers for delivery of therapeutic agent and methods of making the same
EP2563459A1 (en) 2010-04-30 2013-03-06 Boston Scientific Scimed, Inc. Therapeutic agent delivery device for delivery of a neurotoxin
EP2566531A1 (en) 2010-05-07 2013-03-13 Boston Scientific Scimed, Inc. Medical devices employing electroactive polymers for delivery of particulate therapeutic agents
US20110301565A1 (en) 2010-06-07 2011-12-08 Boston Scientific Scimed, Inc. Medical balloons having a sheath designed to facilitate release of therapeutic agent
EP2611476B1 (en) 2010-09-02 2016-08-10 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
WO2012054129A1 (en) 2010-10-18 2012-04-26 Boston Scientific Scimed, Inc. Drug eluting medical device utilizing bioadhesives
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102573946A (en) * 2009-10-16 2012-07-11 汉莫堤克股份有限公司 Use of compositions to coat catheter balloons and coated catheter balloons
WO2019222843A1 (en) * 2018-05-22 2019-11-28 Interface Biologics, Inc. Compositions and methods for delivering drugs to a vessel wall
US11318232B2 (en) 2018-05-22 2022-05-03 Interface Biologics, Inc. Compositions and methods for delivering drugs to a vessel wall

Also Published As

Publication number Publication date
WO2008086794A2 (en) 2008-07-24
US8597720B2 (en) 2013-12-03
BRPI0823269B8 (en) 2021-06-22
KR20100126824A (en) 2010-12-02
CN101972492B (en) 2014-12-10
AU2008207191B2 (en) 2011-02-24
EP2491962A1 (en) 2012-08-29
KR20120106880A (en) 2012-09-26
ES2409759T3 (en) 2013-06-27
JP2011120930A (en) 2011-06-23
CA2673991C (en) 2012-02-07
ES2393639T3 (en) 2012-12-26
WO2008086794A3 (en) 2010-01-14
AU2008207191A1 (en) 2008-07-24
BRPI0806727B8 (en) 2021-06-22
US20100179475A1 (en) 2010-07-15
RU2009131598A (en) 2011-02-27
BRPI0806727B1 (en) 2018-07-17
AU2010235980B2 (en) 2011-10-27
IL199568A (en) 2012-08-30
KR20090114409A (en) 2009-11-03
EP2269664A3 (en) 2011-06-08
PL2136853T3 (en) 2013-08-30
BRPI0823269A2 (en) 2013-11-12
KR101198980B1 (en) 2012-11-07
RU2458710C2 (en) 2012-08-20
JP4908639B2 (en) 2012-04-04
IL208682A0 (en) 2010-12-30
BRPI0823269B1 (en) 2018-07-17
MX336844B (en) 2016-02-03
NZ578341A (en) 2011-06-30
CN101687066A (en) 2010-03-31
EP2136853A2 (en) 2009-12-30
CA2743022A1 (en) 2008-07-24
BRPI0806727A2 (en) 2011-09-13
EP2269664B1 (en) 2012-08-22
CN101687066B (en) 2013-09-11
EP2269664A2 (en) 2011-01-05
RU2447901C2 (en) 2012-04-20
IL208682A (en) 2015-07-30
MX2009007663A (en) 2009-10-13
ZA201007601B (en) 2011-10-26
RU2010141846A (en) 2012-04-20
PL2269664T3 (en) 2013-03-29
NZ588816A (en) 2011-11-25
KR101144984B1 (en) 2012-05-21
JP4906926B2 (en) 2012-03-28
US20110287169A1 (en) 2011-11-24
DE112008000881A5 (en) 2010-01-21
CN101972492A (en) 2011-02-16
AU2010235980A1 (en) 2010-11-11
JP2010516307A (en) 2010-05-20
CA2743022C (en) 2012-10-09
EP2136853B1 (en) 2013-04-10

Similar Documents

Publication Publication Date Title
CA2673991A1 (en) Methods for coating catheter balloons with a defined quantity of active agent
EP1277446B1 (en) Dental material container with porous flow through applicator
US8291570B2 (en) Methods for abluminally coating medical devices
US8359998B2 (en) Stent coating apparatus and method
CN103079969A (en) Knocking-type discharge container
US5389148A (en) Spray apparatus utilizing porous sheet
US20030099746A1 (en) Food decorating apparatus and method
JPH1085037A (en) Applicator unit for liquid or semi-liquid product
CN102813604A (en) Direct inkjet fabrication of drug delivery devices
US9968532B2 (en) Apparatus and methods for concealing vitiligo
CA2867154A1 (en) Precision liquid applicator
NO316931B1 (en) Method and apparatus for applying a fibrin sealant
JP2009022279A (en) Device and method for manufacturing sausage
US20120016320A1 (en) Method and Device for Liquid Delivery
JP4010577B2 (en) A printing press equipped with a material for pasting spacing material on the printed paper
CN103857309A (en) Application device
US9266139B2 (en) Paint/stain stick pad with roller/pad applicator
US9375399B2 (en) Method of coating microneedle devices
JP2020179602A5 (en)
JP2535318Y2 (en) Cosmetic core
DE102014211009B4 (en) Fluid delivery syringe, plunger for use with a delivery syringe and method for reducing plunger return
CN114618701A (en) Injection device
JP2000308843A (en) Needle used in dispenser
JPS6227903A (en) Cosmetics coater
WO2013038137A1 (en) Method of coating microneedle devices

Legal Events

Date Code Title Description
EEER Examination request