CA2675170A1 - Two piece cancellous construct for cartilage repair - Google Patents
Two piece cancellous construct for cartilage repair Download PDFInfo
- Publication number
- CA2675170A1 CA2675170A1 CA002675170A CA2675170A CA2675170A1 CA 2675170 A1 CA2675170 A1 CA 2675170A1 CA 002675170 A CA002675170 A CA 002675170A CA 2675170 A CA2675170 A CA 2675170A CA 2675170 A1 CA2675170 A1 CA 2675170A1
- Authority
- CA
- Canada
- Prior art keywords
- bore
- base member
- cartilage
- repair assembly
- cartilage repair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct (20) with a demineralized cancellous cap (30) and a mineralized cylindrical base member (22) defining a blind bore (23) wrth a through going transverse bore (28) intersecting the blind bore (23). The demineralized cancellous cap (30) has a cylindrical top portion (32) and a smaller diameter cylindrical stem (36) extending away from the top portion (32) which fits into the blind bore (23) of the mineralized base member (22). The cap stem (36) defines a transverse through going bore (37) which is aligned with the through going bore (28) of the base member (22) to receive a cylindrical cortical pin (40) holding the cap (30) within the base member (22). The shaped structure (20) is dimensioned to fit in a drilled bore in a cartilage delect area so that the assembly engages the side wall of the drilled bore in an interference fit.
Description
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Claims (24)
1. A cartilage repair assembly for repair of a defect in articular cartilage comprising an allograft bone base member and a cancellous allograft bone cap member mounted to said base member, said cap member possessing at least one substantially demineralized region.
2. A cartilage repair assembly for repair of a defect in articular cartilage comprising a sterile mineralized allograft bone base member defining an axial bore and a through going bore intersecting said axial bore, a demineralized cancellous allograft bone cap member mounted to said base member in said axial bore, said cap member being treated to be non-osteoinductive, said cap member defining a through going bore which is adapted to be aligned with said base member through going bore, said allograft bone base member being sized to have an interference fit in a cut away opening in a cartilage defect area and fastening means inserted through said base member and cap member hold the same in a fixed relationship.
3. A cartilage repair assembly as claimed in claim 2 wherein said mineralized allograft bone base member is cylindrically shaped.
4. A cartilage repair assembly as claimed in claim 2 wherein said allograft bone base member axial bore is a blind bore with at least one through going bore running from the base of said blind bore to the distal end of the base member.
5. A cartilage repair assembly as claimed in claim 2 wherein said allograft bone base member has a plurality of through going bores running the length of the base member.
6. A cartilage repair assembly as claimed in claim 2 wherein said cap member comprises a top disc shaped section and a stem extending from said top disc shaped section.
7. A cartilage repair assembly as claimed in claim 6 wherein said stem defines a through going bore running transverse the axis of the stem.
8. A cartilage repair assembly as claimed in claim 6 wherein said cap member top section is cylindrical and is about 3mm in thickness.
9. A cartilage repair assembly as claimed in claim 5 wherein said plurality of through going bores run parallel to the center axis of the base member.
10. A cartilage repair assembly as claimed in claim 2 wherein said cap member is demineralized to a calcium content of less than 0.2 percent and treated to remove osteoinductivity.
11. A cartilage repair assembly as claimed in claim 9 wherein said bores have a diameter ranging from about 0.5mm to about 2.0mm.
12. A cartilage repair assembly as claimed in claim 2 wherein said fastening means is a cylindrical pin member mounted in said base member bore and said cap member through going bore.
13. A cartilage repair assembly as claimed in claim 2 wherein said fastening means is constructed of allograft cortical bone.
14. A cartilage repair assembly as claimed in claim 6 wherein said cap member top section has a top surface is milled to a degree of curvature that matches the physiological curvature of the cartilage area being repaired.
15. A cartilage repair assembly as claimed in claim 2 wherein said cap member contains milled cartilage pieces and a carrier.
16. A cartilage repair assembly as claimed in claim 2 wherein said cap member contains one or more additives taken from a group consisting of growth factors(FGF-2, FGF-5, FGF-7, IGF-1, TGF-.beta., BMP-2, BMP-4, BMP-7, PDGF, VEGF), human allogenic or autologous chondrocytes, human allogenic or autologous bone marrow cells, stem cells, demineralized bone matrix, insulin, insulin-like growth factor-1, transforming growth factor-B, interleukin-1 receptor antagonist, hepatocyte growth factor, platelet-derived growth factor, Indian hedgehog and parathyroid hormone-related peptide or bioactive glue.
17. A cartilage repair assembly as claimed in claim 2 wherein on the top section of said cap member is demineralized to a residual calcium content less than 0.2%.
18. A cartilage repair assembly as claimed in claim 2 wherein said cap member is constructed with a disc shaped section having at least a top portion non-osteoinductive and a cylindrical shaped stem section extending from said disc shaped section.
19. A cartilage repair assembly for repair of a defect in articular cartilage comprising a cylindrical sterile mineralized allograft bone base member defining a blind bore and a through going bore communicating with said blind bore and positioned transverse to a central axis of said cylindrical base member, an allograft cancellous bone cap member demineralized to have a calcium content of less than 0.2 percent and treated to remove osteoinductivity mounted in said base member blind bore, said cap member including an extended stem which defines a through going bore which can be aligned with said base member through going bore, said allograft bone base member being sized to have an interference fit in a drilled bore in a cartilage defect area and cylindrical pin member mounted in said base member through going bore and said cap member stem through going bore.
20. A cartilage repair assembly for repair of a defect in articular cartilage comprising a sterile mineralized allograft bone base member defining a blind bore, a transverse through going bore intersecting said blind bore, a plurality of through going bores running through said base member parallel to a central axis of the base member and a demineralized cancellous allograft bone cap member mounted to said base member, said cap member being treated to remove osteoinductivity, said cap member defining a through going bore which can be aligned with said bore member bone cartilage cap, said allograft bone base member being sized to have an interference fit in a drilled bore in a cartilage defect area.
21. A cartilage repair assembly as claimed in claim 20 wherein said cap member is demineralized so that it has a calcium content less than 0.2 percent.
22. A cartilage repair assembly as claimed in claim 20 wherein said cartilage repair assembly is cylindrically shaped.
23. A cartilage repair assembly as claimed in claim 20 wherein said cap member contains one or more additives taken from a group consisting of growth factors(FGF-2, FGF-5, FGF-7, IGF-1, TGF-.beta., BMP-2, BMP-4, BMP-7, PDGF, VEGF), human allogenic or autologous chondrocytes, human allogenic or autologous bone marrow cells, stem cells, demineralized bone matrix, insulin, insulin-like growth factor-1, transforming growth factor-B, interleukin-1 receptor antagonist, hepatocyte growth factor, platelet-derived growth factor, Indian hedgehog and parathyroid hormone-related peptide or bioactive glue.
24. A cartilage repair assembly as claimed in claim 20 wherein said cap member has a top surface that is curved to match the physiological curvature of the cartilage area being replaced.
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PCT/US2008/051796 WO2008106254A2 (en) | 2007-01-24 | 2008-01-23 | Two piece cancellous construct for cartilage repair |
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Cited By (2)
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CN112704588A (en) * | 2020-12-21 | 2021-04-27 | 济宁医学院附属医院 | Personalized customized articular cartilage injury repair device based on 3D printing |
CN112704588B (en) * | 2020-12-21 | 2022-07-29 | 济宁医学院附属医院 | Individualized customization articular cartilage damage prosthetic devices based on 3D prints |
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WO2008106254A2 (en) | 2008-09-04 |
US7837740B2 (en) | 2010-11-23 |
WO2008106254A3 (en) | 2009-07-30 |
US20110224797A1 (en) | 2011-09-15 |
CA2675170C (en) | 2014-09-30 |
EP2162094A2 (en) | 2010-03-17 |
US20080255676A1 (en) | 2008-10-16 |
US8906110B2 (en) | 2014-12-09 |
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