CA2680070C - Insertion system for corneal implants - Google Patents
Insertion system for corneal implants Download PDFInfo
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- CA2680070C CA2680070C CA2680070A CA2680070A CA2680070C CA 2680070 C CA2680070 C CA 2680070C CA 2680070 A CA2680070 A CA 2680070A CA 2680070 A CA2680070 A CA 2680070A CA 2680070 C CA2680070 C CA 2680070C
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- implant
- holding space
- inserter
- corneal
- insertion system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/148—Implantation instruments specially adapted therefor
Abstract
Provided therein are apparatuses, systems and methods for storing and retrieving a corneal implant and for delivering the corneal implant in or on the cornea. In an embodiment, a insertion system comprises an inserter for delivering a corneal implant to a desired location in or on the cornea. The inserter has a holding space at its distal end for holding a corneal implant therein. A solution may substantially fill the holding space with the corneal implant to keep the implant hydrated and to hold the implant in the holding space by the surface tension of the solution. The corneal implant may be preloaded in the holding space of the inserter and stored in a storage container filled with storage fluid, e.g., saline, until use. To deliver the corneal implant, the inserter is positioned at the desired location, and the corneal implant released from the holding space of the inserter.
Description
INSERTION SYSTEM FOR CORNEAL IMPLANTS
FIELD OF THE INVENTION
[0001] The field of the invention relates generally to corneal implants, and more particular, to insertion systems for corneal implants.
BACKGROUND INFORMATION
FIELD OF THE INVENTION
[0001] The field of the invention relates generally to corneal implants, and more particular, to insertion systems for corneal implants.
BACKGROUND INFORMATION
[0002] As is well known, abnormalities in the human eye can lead to vision impairment. Some typical abnormalities include variations in the shape of the eye, which can lead to myopia (near-sightedness), hyperopia (far-sightedness) and astigmatism as well as variations in the tissue present throughout the eye, such as a reduction in the elasticity of the lens, which can lead to presbyopia. A variety of technologies have been developed to try and address these abnormalities, including corneal implants.
[0003] Corneal implants can correct vision impairment by altering the shape of the cornea. Corneal implants can be classified as an onlay or an inlay. An onlay is an implant that is placed over the cornea such that the outer layer of the cornea, e.g., the epithelium, can grow over and encompass the implant. An inlay is an implant that is surgically implanted into the cornea beneath a portion of the corneal tissue by, for example, cutting a flap in the cornea and inserting the inlay beneath the flap. Both inlays and outlays can alter the refractive power of the cornea by changing the shape of the anterior cornea, by having a different index of refraction than the cornea, or both. Since the cornea is the strongest refracting optical element in the human ocular system, altering the cornea's anterior surface is a particularly useful method for correcting vision impairments caused by refractive errors.
[0004] There is a need for improved apparatuses, systems and methods for storing a corneal implant prior to use and for retrieving the corneal implant from storage during a surgical procedure. There is also a need for improved apparatuses, systems and methods for delivering a corneal implant to the cornea and for precisely depositing the corneal implant at a desired location in or on the cornea without damaging the corneal implant.
SUMMARY
SUMMARY
[0005] Provided herein are apparatuses, systems and methods for storing and retrieving a corneal implant and for delivering the corneal implant in or on the cornea.
[0006] In an embodiment, an insertion system comprises an inserter for delivering a corneal implant to a desired location in or on the cornea. The inserter comprises an elongated body having a distal end and a proximal end. The elongated body has a holding space at its distal end for holding the corneal implant to be delivered. The holding space is formed between a top distal portion and a bottom distal portion of the elongated body. In a preferred embodiment, a solution, e.g., saline, substantially fills the holding space with the corneal implant to keep the implant hydrated and to hold the implant in the holding space by the surface tension of the solution. The elongated body of the inserter may also have a curved portion that follows the curvature of the cornea and a clearance bend that provides clearance between the inserter and a facial feature, e.g., nose, of the patient.
[0007] In an embodiment, the corneal implant is preloaded in the holding space of the inserter and the preloaded inserter is stored in a storage container filled with storage fluid, e.g., saline, until use. In one embodiment, a cap is placed on the distal end of the inserter after the implant is preloaded. The cap encloses the holding space of the inserter to prevent the corneal implant from moving out of the holding space in the storage fluid during storage. By preloading the implant in the inserter, the surgeon does not have to separately retrieve the implant and place the implant in the inserter, which is difficult due to the small size and delicate nature of the implant.
[0008] A method of delivering a corneal implant according to an embodiment includes positioning an inserter with the corneal implant at a desired location in or on the cornea. At the desired location, the corneal implant is held down in the holding space of the inserter by a surgical tool, e.g., cannula. The surgical tool accesses the implant in the holding space through a slot in the inserter. While the corneal implant is held down by the surgical tool, the inserter is retracted to release the corneal implant from the inserter and deposit the corneal implant at the desired location. By holding down the implant at the desired location and retracting the inserter to release the implant, the surgeon is able to precisely deposit the implant at the desired location.
[0009] Other systems, methods, features and advantages of the invention will be or will become apparent to one with skill in the art upon examination of the following figures and detailed description. The scope of the claims should not be limited by particular embodiments set forth herein, but should be construed in a manner consistent with the specification as a whole.
BRIEF DESCRIPTION OF THE FIGURES
BRIEF DESCRIPTION OF THE FIGURES
[0010] FIG. 1 shows a perspective view of an insertion system comprising an inserter and a cap according to an embodiment of the present invention.
[0011] FIG. 2 shows a perspective view of the cap placed on the inserter according to an embodiment of the present invention.
[0012] FIG. 3 shows a side view of the distal end of the inserter according to an embodiment of the present invention.
[0013] FIG. 4 shows a close-up perspective view of the distal end of the inserter according to an embodiment of the present invention.
[0014] FIG. 5A shows the inserter depositing a corneal implant on the cornea according to an embodiment of the present invention.
[0015] FIG. 5B shows a close-up of the inserter depositing the corneal implant on the cornea.
[0016] FIG. 5C shows the inserter depositing a corneal implant on an interior surface of the cornea exposed by forming a flap in the cornea according to an embodiment of the invention.
[0017] FIG. 5D shows the inserter depositing a corneal implant within a pocket formed in the cornea according to an embodiment of the present invention.
[0018] FIG. 6 shows the inserter and cap stored in a container filled with storage fluid according to an embodiment of the present invention.
[0019] FIG. 7 shows a perspective view of the inserter with a luer lock attached to the proximal end of the inserter according to an embodiment of the present invention.
[0020] FIG. 8 shows a perspective view of the inserter with a syringe connected to the proximal end of the inserter according to an embodiment of the present invention.
[0021] FIG. 9 shows a perspective view of an inserter according to another embodiment of the present invention.
[0022] FIG. 10 shows a back view of the distal end of the inserter according to an embodiment of the present invention.
[0023] FIG. 11 shows the inserter depositing a corneal implant on the cornea according to an embodiment of the present invention.
DETAILED DESCRIPTION
DETAILED DESCRIPTION
[0024] Figures 1-5 show an insertion system according to an embodiment that is particular suited for delivering a corneal implant, e.g., inlay, in or on the cornea. The insertion system is also suited for storing the implant prior to its use. The insertion system includes an inserter 100 having an elongated body, which may be made of titanium, stainless steel, plastic, or other biocompatible material. The inserter 100 comprises a distal portion having generally flat top and bottom surfaces. The distal portion of the inserter 100 includes a clearance bend 104 where the inserter is bent to provide clearance between the inserter and a patient's facial features (e.g., nose, cheeks, etc.) as explained further below. The distal portion of the inserter 100 also includes a curved portion 103 that is contoured to follow the shape of a patient's cornea as explained further below. The curved portion 103 is concaved on the bottom surface of the inserter 100.
[0025] The inserter 100 further includes a holding space 101 for holding a corneal implant 200 to be delivered by the inserter. Preferably, saline, BSS or other solution (not shown) is placed in the holding space 101 to hold the implant 200 therein due to surface tension of the saline. The saline stays in the holding space 101 due to capillary forces, thereby keeping the implant hydrated. The inserter also includes top and bottom inserter slots 102 and 110 as shown in Figure 4. As explained below, the inserter slots 102 and 110 allow a surgeon to view the patient's cornea through the slots for precise placement of the implant 200. In addition, the top inserter slot 102 allows the surgeon to hold down the implant 200 in the holding space 101 at a desired position while the surgeon retracts the inserter 100 to release the implant 200. The surgeon may hold down the implant 200 with a surgical tool, such as a cannula, Sinskey hook or other tool that can fit through the top inserter slot 102. The top inserter slot 102 extends to the leading edge 111 of the inserter 100 so that the tool can hold down the implant 200 as the inserter 100 is retracted. The leading edge 111 of the inserter is preferably rounded to prevent damage to the cornea.
[0026] In the preferred embodiment, the width "w" of the holding space 101 is slightly larger than the diameter of the implant 200 to be delivered by the inserter 100 as shown in Figure 3. In an exemplary embodiment, the implant 200 has a diameter of about 1.5 mm and the width "w" of the holding space 101 is between 1.6 and 1.7 mm.
The rounded leading edge 111 of the inserter 100 follows the perimeter of the implant 200.
The center length "1" of the holding space 101 is slightly larger than the diameter of the implant 200. As shown in Figure 3, the center length "1" extends from the center of the leading edge 111 to the back wall 113 of the holding space 101. The geometry of the holding space 101 and the surface tension of the saline in the holding space 101 keep the implant 200 substantially centered in the inserter 100. The height of the holding space 101 may be several times larger than the center thickness of the implant 200 to ensure that enough saline is in the holding space 101 to keep the implant sufficiently hydrated.
The rounded leading edge 111 of the inserter 100 follows the perimeter of the implant 200.
The center length "1" of the holding space 101 is slightly larger than the diameter of the implant 200. As shown in Figure 3, the center length "1" extends from the center of the leading edge 111 to the back wall 113 of the holding space 101. The geometry of the holding space 101 and the surface tension of the saline in the holding space 101 keep the implant 200 substantially centered in the inserter 100. The height of the holding space 101 may be several times larger than the center thickness of the implant 200 to ensure that enough saline is in the holding space 101 to keep the implant sufficiently hydrated.
[0027] The inserter 100 may be manufactured from a rod that is cut and bent to form the inserter 100. In one embodiment, a cylindrical titanium rod is cut and bent to form the inserter 100. In this embodiment, the proximal portion of the inserter 100 is generally cylindrical with angled portions that taper down to the distal portion of the inserter 100.
[0028] The inserter system further includes an inserter cap 300, which may be made of Teflon (PTFE). In an embodiment, the inserter cap 300 is generally cylindrical and can be fitted snugly on the distal end of the inserter 100 by engaging the sides of the inserter 100 as shown in Figure 2.
[0029] In a preferred embodiment, the implant 200 is preloaded in the inserter 100 and packaged for later use by the surgeon during an implantation procedure. In this embodiment, the implant is 200 preloaded into the holding space 101 of the inserter 100 with the top surface of the implant 200 orientated to face the top surface of the inserter 100. The implant 200 may be preloaded by submerging both the implant 200 and the holding space 101 of the inserter 100 in a solution, e.g., saline, and inserting the implant 200 into the holding space 101 while they are both submerged. After the implant 200 is preloaded in the inserter 100, the inserter cap 300 is placed on the distal end of the inserter 100. The cap 300 may be placed on the inserter 100 while the holding space 101 is still submerged in the solution. The preloaded inserter 100 assembled with the inserter cap 300 is placed into a vial 400 or other storage container filled with saline 410 or other suitable solution as shown in Figure 6. The inserter cap 300 prevents the implant 200 from moving out of the inserter 100 when placed in the vial 400 filled with saline 410.
The vial 400 is capped and placed in an outer package 420, which is sterilized to store the insertion system until use.
The vial 400 is capped and placed in an outer package 420, which is sterilized to store the insertion system until use.
[0030] An implantation procedure using an insertion system according to an embodiment will now be given. In this embodiment, the preloaded inserter 100 is removed from the outer package 420 and the vial 400 filled with saline 410.
The saline within the space between the inserter cap 300 and the inserter 101 is then removed by placing a sterile surgical sponge (not shown) or other absorbent material on the open end on the inserter cap 300. The sponge draws out the saline from the interior of the cap 300 by capillary action through the opening between the cap 300 and the inserter 101. In the embodiment in which the cap 300 has a generally cylindrical shape, the opening is formed between the cylindrical cap 300 and the flat top and bottom surfaces of the inserter 100. The saline is removed from the spaced between the cap 300 and the inserter 100 while the cap 300 is still on the inserter 100. This is done to prevent the cap 300 from pulling the implant 200 out of the inserter 100 by capillary action when the cap 300 is removed from the inserter 100. After the saline is removed, the cap 300 is removed from the inserter 100. At this point, a small amount of saline or BSS may be applied to the holding space 101 of the inserter 100 to keep the implant 200 hydrated. The saline stays in the holding space 101 due to capillary forces, thereby keeping the implant 200 hydrated during the procedure. Further, the surface tension of the saline holds the implant 200 in the holding space 101 of the inserter 100 so that the implant 200 does not fall out of the inserter 100 during the procedure. This surface tension and the geometry of the holding space 101 keep the implant 200 centered in the inserter 100. To enable a surgeon to better hold the inserter 100, a handle 500 may be attached to the proximal end of the inserter 100 as shown in Figure 5A. The handle may be similar to handles that attach to disposable blades.
Further, the surgeon may determine the proper orientation of the implant based on features of the inserter 100. For example, when the top of the inserter 100, and hence the implant 200, are facing upward, the concaved bottom surface of the curved portion 103 of the inserter 100 is facing downward.
The surgeon may then implant the corneal implant 200 in the patient's cornea.
To access the interior of the cornea, a flap may be cut into the cornea and lifted to expose the cornea's interior, e.g., stroma bed of the cornea. An example of this is shown in Figure 5C, in which a flap 1120 is cut into the cornea 600 and pulled backed to expose the stroma bed 1100 of the cornea. The flap 1120 is attached to the cornea 600 by a flap hinge 1110.
The flap 1120 may be cut using a laser, e.g., femtosecond laser, a mechanical keratome or manually. Several methods for forming flaps in corneal tissue, and other related information, are described in further detail in co-pending U.S. Patent Application Serial No. 10/924,152, filed August 23, 2004, entitled "Method for Keratophakia Surgery". Once the interior is exposed, the surgeon positions the inserter 100 so that implant 200 is at the desired location on the cornea 600, e.g., the patient's pupil or visual axis as shown in Figure 5A. Prior to positioning the inserter 100, the surgeon may use a surgical sponge to remove excess fluid on the outer surface of the inserter 100 being careful not to remove the saline from the holding space 101. The clearance bend 104 allows the inserter to clear the patient's facial features (e.g., nose) as the surgeon manipulates the inserter 100. To precisely position the implant 200 the surgeon may view the cornea 600 through the inserter slots 102 and 110 and the implant 200, which is transparent. When the implant 200 is at the desired location, the surgeon holds down the implant 200 on the cornea 600 using a surgical carmula, Sinskey Hook or other tool 610 such that implant 200 gently touches the stroma bed of the cornea 600 through the bottom slot 110. This tool 610 holds down the implant 200 through the top inserter slot 102 as shown in Figure 5B. The surgeon then retracts the inserter 100 from the cornea 600 to release the implant 200 from the inserter 100 and deposit the implant 200 at the desired location. If the implant 200 is not precisely at the desired location, then the surgeon may gently move the implant 200 into position using a surgical sponge, rounded-tip tool, or other tool. In the example shown in Figure 5C, the implant 200 is centered on the patient's pupil 1130. After the implant 200 is correctly positioned, the surgeon places the flap 1120 over the implant 200.
[0032] The implant 200 may be implanted concurrent with a LASIK procedure or post-LASIK. Since a flap is cut into the cornea during a LASIK procedure, the same flap may be used to implant the implant 200. If the implant 200 is implanted post-LASIK, then the LASIK flap may be re-opened or the inserter 100 may be advanced between the flap and the underlying corneal tissue to the desired position. In this example, the LASIK procedure may be used to correct distance vision while the implant is used to provide near vision.
Additional details can be found, for example, in U.S. Patent Application Serial No. 11/554,544, entitled "Small Diameter Inlays, "filed on October 30, 2006.
[0033] The implant 200 may also be implanted through a closed flap instead of an open flap. In this embodiment, the distal portion of the inserter 100 may be inserted between the flap and the underlying corneal tissue and advanced between the flap and underlying corneal tissue to the desired position in the cornea. The distal portion of the inserter 100 preferably has a thin cross-section so that the inserter 100 does not induce corneal wound stretching. The curved portion 103 of the inserter 100 follows the curvature of the cornea allowing the inserter to more easily move between the flap and underlying corneal tissue while minimizing stress on the cornea. Further, the top surface of the inserter 100 preferably a downward slopping portion 115 that slopes downward to the leading edge 111 of the inserter 100 as shown in Figure 3. In this embodiment, a surgical cannula or other tool may also be inserted between the flap and the underlying corneal tissue to hold down the implant 200 at the desired location and release the implant 200 from the inserter 100.
100341 The implant 200 may also be implanted using different methods to access the interior of the cornea. For example, the interior of the cornea may be accessed through a lamellar pocket, channel, or pathway cut into the cornea. Additional details may be found, for example, in U.S. Patent Application Serial No. 11/421,597, entitled "Ocular Tissue Separation Areas With Barrier Regions For Inlays Or Other Refractive Procedures, " filed on June 1, 2006. Methods for creating pockets in the cornea are described in United States Patent Application Publication No.
2003/0014042, published January 16, 2003, entitled "Method of Creating Stromal Pockets for Corneal Implants". For example, the inserter may be inserted into a channel or pocket cut into the cornea and advanced through the channel to position the implant at the desired location in the cornea. A second channel may also be cut into the cornea to provide access for the surgical cannula or other tool used to hold down the implant at the desired location. A
pocket is a recess formed within the corneal tissue for receiving the corneal implant and may be accessed through a channel formed in the cornea. Figure 5D shows an example of the inserter 100 placing the implant 200 within a pocket 700 in formed in the cornea 600 through an opening 710.
100351 In another embodiment, the inserter 100 may include a channel running through the inserter 100 and extending from the proximal end of the inserter 100 to the holding space 101. The proximal end of the inserter 100 may be connected to a syringe filled with fluid, e.g., saline, for delivering fluid to the holding space 101 through the channel. In this embodiment, the channel may deliver fluid at the back of the holding space 101. This allows a surgeon to deliver a small amount of fluid into the holding space 101 to hydrate the implant 200 and/or gently push the implant 200 out of the holding space 101 for releasing the implant 200 from the inserter 100.
For example, when the implant 200 is at the desired location on the cornea, the surgeon may deliver fluid through the channel to help release the implant 200 from the inserter 101. This may be done instead of or in conjunction with the tool used to hold down the implant 200. Figure 7 shows an inserter 100 according one embodiment comprising a luer lock 810 at the proximal end of the inserter 100 that is configured to mate with a corresponding luer lock of a syringe or other fluid delivering device. Figure 8 shows an embodiment in which a syringe 820 is connected to the proximal end of the inserter 100 via the luer lock 810 for delivering fluid through the channel.
[0036] Figures 9 and 10 show a distal portion of an inserter 900 according to another embodiment. In this embodiment, the inserter 900 comprises a cannula 910 or tube configured to hold the implant 1000 therein for delivery to the cornea.
The cannula 910 preferably has a width slightly larger than the width of the implant 1000 to be delivered by the inserter 900. The cannula 910 also preferably has a height that is slightly larger than the thickness of the implant 1000. The distal end 920 of the cannula 910 is preferably shaped to hold the implant 1000 in an unstressed state. The cannula 910 may be slightly curved along its width and/or length to follow the curvature of the cornea.
Fluid, e.g., saline or BSS, may be delivered to the implant 1000 through a channel in the inserter 900 to ensure that the implant 1000 is hydrated prior to use and/or to release the implant 1000 from the inserter 900.
[0037] The inserter 900 also includes a top inserter slot 930 through which a surgical cannula, Sinskey Hook or other tool can be used to hold down the implant 1000 at the desired location in the cornea. The inserter 900 also includes a bottom opening 940 through which the implant 1000 can contact the cornea when the implant is held down as shown in Figure 10. Preferably, the edges and corners at the tip of the cannula 910 are smooth and rounded to prevent cutting by the cannula 910 and damage to the cornea or implant from the tip of the cannula. A handle may be attached to the proximal end of the inserter for easier handling by the surgeon. Further, a syringe or other fluid delivering device may be connected to the inserter 900 for delivering fluid to the implant through the channel in the inserter 900. Figure 11 shows the entire inerter 910, which includes a clearance bend 945 and an elongated portion 950 with an optional luer lock 960 at the proximal end of the inserter 910 for connecting, e.g., a fluid delivering device to the inserter 910.
[0038] The implant 1000 may be implanted in the cornea using procedures similar to the ones discussed above. For example, a flap may be cut into the cornea and lifted to expose a stroma bed of the cornea. The surgeon may then position the implant 1000 at the desired location using the inserter 900. When the implant 1000 is at the desired position, the surgeon may use a surgical cannula or other tool to hold the implant 1000 through the top inserter slot 930. The surgeon may hold down the implant 1000 such that the bottom surface of the implant 1000 contacts the cornea through the bottom opening 940 of the inserter 900. While the implant 1000 is held down at the desired location, the surgeon retracts the inserter 900 to deposit the implant 1000 on the cornea. The surgeon may also deliver fluid to the implant 1000 through the channel in the inserter to release the implant 1000 from the inserter 900. After the implant 1000 is correctly positioned, the surgeon places the flap over the implant 1000. Figure 11 shows an example of the inserter 900 positioned over the desired location of the cornea for depositing the implant 1000 at the desired location.
[0039] The implant 1000 may also be implanted using other procedures including implantation through a channel, pocket or pathway cut into the cornea for access to the desired position in the cornea. In these procedures, the inserter 900 may be moved to the desired position through the channel, pocket or pathway. The thin cross section of the inserter 900 minimizes stress on the cornea as the inserter 900 is advanced through the channel, pocket or pathway. A second channel may also be cut into the cornea to provide access for the surgical tool used to hold down the implant 1000 at the desired location.
[0040] The inserter systems described herein may to used to implant various types of corneal implant. For example, the inserter systems may be used to implant corneal implants deep within the cornea such as intraocular lenses or at lower depths such as inlays. The inserter systems may also be used to place an onlay on the surface of the cornea. Thus, the inserter systems may be used to implant corneal implants of various rigidity, sizes and properties at various depths in the cornea. The corneal implant may be an inlay, lens, or the like.
[0041] In the foregoing specification, the invention has been described with reference to specific embodiments thereof. It will, however, be evident that various modifications and changes may be made thereto. The scope of the claims should not be limited by particular embodiments set forth herein, but should be construed in a manner consistent with the specification as a whole. As another example, each feature of one embodiment can be mixed and matched with other features shown in other embodiments.
As yet another example, the order of steps of method embodiments may be changed.
Features and processes known to those of ordinary skill may similarly be incorporated as desired. Additionally and obviously, features may be added or subtracted as desired.
Accordingly, the invention is not to be restricted except in light of the attached claims construed in light of the specification as a whole.
The saline within the space between the inserter cap 300 and the inserter 101 is then removed by placing a sterile surgical sponge (not shown) or other absorbent material on the open end on the inserter cap 300. The sponge draws out the saline from the interior of the cap 300 by capillary action through the opening between the cap 300 and the inserter 101. In the embodiment in which the cap 300 has a generally cylindrical shape, the opening is formed between the cylindrical cap 300 and the flat top and bottom surfaces of the inserter 100. The saline is removed from the spaced between the cap 300 and the inserter 100 while the cap 300 is still on the inserter 100. This is done to prevent the cap 300 from pulling the implant 200 out of the inserter 100 by capillary action when the cap 300 is removed from the inserter 100. After the saline is removed, the cap 300 is removed from the inserter 100. At this point, a small amount of saline or BSS may be applied to the holding space 101 of the inserter 100 to keep the implant 200 hydrated. The saline stays in the holding space 101 due to capillary forces, thereby keeping the implant 200 hydrated during the procedure. Further, the surface tension of the saline holds the implant 200 in the holding space 101 of the inserter 100 so that the implant 200 does not fall out of the inserter 100 during the procedure. This surface tension and the geometry of the holding space 101 keep the implant 200 centered in the inserter 100. To enable a surgeon to better hold the inserter 100, a handle 500 may be attached to the proximal end of the inserter 100 as shown in Figure 5A. The handle may be similar to handles that attach to disposable blades.
Further, the surgeon may determine the proper orientation of the implant based on features of the inserter 100. For example, when the top of the inserter 100, and hence the implant 200, are facing upward, the concaved bottom surface of the curved portion 103 of the inserter 100 is facing downward.
The surgeon may then implant the corneal implant 200 in the patient's cornea.
To access the interior of the cornea, a flap may be cut into the cornea and lifted to expose the cornea's interior, e.g., stroma bed of the cornea. An example of this is shown in Figure 5C, in which a flap 1120 is cut into the cornea 600 and pulled backed to expose the stroma bed 1100 of the cornea. The flap 1120 is attached to the cornea 600 by a flap hinge 1110.
The flap 1120 may be cut using a laser, e.g., femtosecond laser, a mechanical keratome or manually. Several methods for forming flaps in corneal tissue, and other related information, are described in further detail in co-pending U.S. Patent Application Serial No. 10/924,152, filed August 23, 2004, entitled "Method for Keratophakia Surgery". Once the interior is exposed, the surgeon positions the inserter 100 so that implant 200 is at the desired location on the cornea 600, e.g., the patient's pupil or visual axis as shown in Figure 5A. Prior to positioning the inserter 100, the surgeon may use a surgical sponge to remove excess fluid on the outer surface of the inserter 100 being careful not to remove the saline from the holding space 101. The clearance bend 104 allows the inserter to clear the patient's facial features (e.g., nose) as the surgeon manipulates the inserter 100. To precisely position the implant 200 the surgeon may view the cornea 600 through the inserter slots 102 and 110 and the implant 200, which is transparent. When the implant 200 is at the desired location, the surgeon holds down the implant 200 on the cornea 600 using a surgical carmula, Sinskey Hook or other tool 610 such that implant 200 gently touches the stroma bed of the cornea 600 through the bottom slot 110. This tool 610 holds down the implant 200 through the top inserter slot 102 as shown in Figure 5B. The surgeon then retracts the inserter 100 from the cornea 600 to release the implant 200 from the inserter 100 and deposit the implant 200 at the desired location. If the implant 200 is not precisely at the desired location, then the surgeon may gently move the implant 200 into position using a surgical sponge, rounded-tip tool, or other tool. In the example shown in Figure 5C, the implant 200 is centered on the patient's pupil 1130. After the implant 200 is correctly positioned, the surgeon places the flap 1120 over the implant 200.
[0032] The implant 200 may be implanted concurrent with a LASIK procedure or post-LASIK. Since a flap is cut into the cornea during a LASIK procedure, the same flap may be used to implant the implant 200. If the implant 200 is implanted post-LASIK, then the LASIK flap may be re-opened or the inserter 100 may be advanced between the flap and the underlying corneal tissue to the desired position. In this example, the LASIK procedure may be used to correct distance vision while the implant is used to provide near vision.
Additional details can be found, for example, in U.S. Patent Application Serial No. 11/554,544, entitled "Small Diameter Inlays, "filed on October 30, 2006.
[0033] The implant 200 may also be implanted through a closed flap instead of an open flap. In this embodiment, the distal portion of the inserter 100 may be inserted between the flap and the underlying corneal tissue and advanced between the flap and underlying corneal tissue to the desired position in the cornea. The distal portion of the inserter 100 preferably has a thin cross-section so that the inserter 100 does not induce corneal wound stretching. The curved portion 103 of the inserter 100 follows the curvature of the cornea allowing the inserter to more easily move between the flap and underlying corneal tissue while minimizing stress on the cornea. Further, the top surface of the inserter 100 preferably a downward slopping portion 115 that slopes downward to the leading edge 111 of the inserter 100 as shown in Figure 3. In this embodiment, a surgical cannula or other tool may also be inserted between the flap and the underlying corneal tissue to hold down the implant 200 at the desired location and release the implant 200 from the inserter 100.
100341 The implant 200 may also be implanted using different methods to access the interior of the cornea. For example, the interior of the cornea may be accessed through a lamellar pocket, channel, or pathway cut into the cornea. Additional details may be found, for example, in U.S. Patent Application Serial No. 11/421,597, entitled "Ocular Tissue Separation Areas With Barrier Regions For Inlays Or Other Refractive Procedures, " filed on June 1, 2006. Methods for creating pockets in the cornea are described in United States Patent Application Publication No.
2003/0014042, published January 16, 2003, entitled "Method of Creating Stromal Pockets for Corneal Implants". For example, the inserter may be inserted into a channel or pocket cut into the cornea and advanced through the channel to position the implant at the desired location in the cornea. A second channel may also be cut into the cornea to provide access for the surgical cannula or other tool used to hold down the implant at the desired location. A
pocket is a recess formed within the corneal tissue for receiving the corneal implant and may be accessed through a channel formed in the cornea. Figure 5D shows an example of the inserter 100 placing the implant 200 within a pocket 700 in formed in the cornea 600 through an opening 710.
100351 In another embodiment, the inserter 100 may include a channel running through the inserter 100 and extending from the proximal end of the inserter 100 to the holding space 101. The proximal end of the inserter 100 may be connected to a syringe filled with fluid, e.g., saline, for delivering fluid to the holding space 101 through the channel. In this embodiment, the channel may deliver fluid at the back of the holding space 101. This allows a surgeon to deliver a small amount of fluid into the holding space 101 to hydrate the implant 200 and/or gently push the implant 200 out of the holding space 101 for releasing the implant 200 from the inserter 100.
For example, when the implant 200 is at the desired location on the cornea, the surgeon may deliver fluid through the channel to help release the implant 200 from the inserter 101. This may be done instead of or in conjunction with the tool used to hold down the implant 200. Figure 7 shows an inserter 100 according one embodiment comprising a luer lock 810 at the proximal end of the inserter 100 that is configured to mate with a corresponding luer lock of a syringe or other fluid delivering device. Figure 8 shows an embodiment in which a syringe 820 is connected to the proximal end of the inserter 100 via the luer lock 810 for delivering fluid through the channel.
[0036] Figures 9 and 10 show a distal portion of an inserter 900 according to another embodiment. In this embodiment, the inserter 900 comprises a cannula 910 or tube configured to hold the implant 1000 therein for delivery to the cornea.
The cannula 910 preferably has a width slightly larger than the width of the implant 1000 to be delivered by the inserter 900. The cannula 910 also preferably has a height that is slightly larger than the thickness of the implant 1000. The distal end 920 of the cannula 910 is preferably shaped to hold the implant 1000 in an unstressed state. The cannula 910 may be slightly curved along its width and/or length to follow the curvature of the cornea.
Fluid, e.g., saline or BSS, may be delivered to the implant 1000 through a channel in the inserter 900 to ensure that the implant 1000 is hydrated prior to use and/or to release the implant 1000 from the inserter 900.
[0037] The inserter 900 also includes a top inserter slot 930 through which a surgical cannula, Sinskey Hook or other tool can be used to hold down the implant 1000 at the desired location in the cornea. The inserter 900 also includes a bottom opening 940 through which the implant 1000 can contact the cornea when the implant is held down as shown in Figure 10. Preferably, the edges and corners at the tip of the cannula 910 are smooth and rounded to prevent cutting by the cannula 910 and damage to the cornea or implant from the tip of the cannula. A handle may be attached to the proximal end of the inserter for easier handling by the surgeon. Further, a syringe or other fluid delivering device may be connected to the inserter 900 for delivering fluid to the implant through the channel in the inserter 900. Figure 11 shows the entire inerter 910, which includes a clearance bend 945 and an elongated portion 950 with an optional luer lock 960 at the proximal end of the inserter 910 for connecting, e.g., a fluid delivering device to the inserter 910.
[0038] The implant 1000 may be implanted in the cornea using procedures similar to the ones discussed above. For example, a flap may be cut into the cornea and lifted to expose a stroma bed of the cornea. The surgeon may then position the implant 1000 at the desired location using the inserter 900. When the implant 1000 is at the desired position, the surgeon may use a surgical cannula or other tool to hold the implant 1000 through the top inserter slot 930. The surgeon may hold down the implant 1000 such that the bottom surface of the implant 1000 contacts the cornea through the bottom opening 940 of the inserter 900. While the implant 1000 is held down at the desired location, the surgeon retracts the inserter 900 to deposit the implant 1000 on the cornea. The surgeon may also deliver fluid to the implant 1000 through the channel in the inserter to release the implant 1000 from the inserter 900. After the implant 1000 is correctly positioned, the surgeon places the flap over the implant 1000. Figure 11 shows an example of the inserter 900 positioned over the desired location of the cornea for depositing the implant 1000 at the desired location.
[0039] The implant 1000 may also be implanted using other procedures including implantation through a channel, pocket or pathway cut into the cornea for access to the desired position in the cornea. In these procedures, the inserter 900 may be moved to the desired position through the channel, pocket or pathway. The thin cross section of the inserter 900 minimizes stress on the cornea as the inserter 900 is advanced through the channel, pocket or pathway. A second channel may also be cut into the cornea to provide access for the surgical tool used to hold down the implant 1000 at the desired location.
[0040] The inserter systems described herein may to used to implant various types of corneal implant. For example, the inserter systems may be used to implant corneal implants deep within the cornea such as intraocular lenses or at lower depths such as inlays. The inserter systems may also be used to place an onlay on the surface of the cornea. Thus, the inserter systems may be used to implant corneal implants of various rigidity, sizes and properties at various depths in the cornea. The corneal implant may be an inlay, lens, or the like.
[0041] In the foregoing specification, the invention has been described with reference to specific embodiments thereof. It will, however, be evident that various modifications and changes may be made thereto. The scope of the claims should not be limited by particular embodiments set forth herein, but should be construed in a manner consistent with the specification as a whole. As another example, each feature of one embodiment can be mixed and matched with other features shown in other embodiments.
As yet another example, the order of steps of method embodiments may be changed.
Features and processes known to those of ordinary skill may similarly be incorporated as desired. Additionally and obviously, features may be added or subtracted as desired.
Accordingly, the invention is not to be restricted except in light of the attached claims construed in light of the specification as a whole.
Claims (22)
1. A corneal implant insertion system comprising:
an elongated body having a distal end and a proximal end;
a holding space at the distal end of the elongated body, wherein the holding space is defined between a top distal portion having a width and a bottom distal portion having a width, wherein the top distal portion is generally flat across its width and the bottom distal portion is generally flat across its width;
a slot through the top distal portion of the elongated body, wherein the slot extends to a leading edge of the elongated body;
a corneal implant retained within the holding space; and a fluid disposed in the holding space such that the corneal implant is retained within the holding space in an unstressed configuration due to the surface tension of the fluid.
an elongated body having a distal end and a proximal end;
a holding space at the distal end of the elongated body, wherein the holding space is defined between a top distal portion having a width and a bottom distal portion having a width, wherein the top distal portion is generally flat across its width and the bottom distal portion is generally flat across its width;
a slot through the top distal portion of the elongated body, wherein the slot extends to a leading edge of the elongated body;
a corneal implant retained within the holding space; and a fluid disposed in the holding space such that the corneal implant is retained within the holding space in an unstressed configuration due to the surface tension of the fluid.
2. The insertion system of claim 1, wherein the holding space has a width that is between a diameter of the corneal implant and 20 percent larger than the diameter of the corneal implant.
3. The insertion system of claim 1 or 2, wherein a top surface of the top distal portion of the elongated body slopes downward relative to the bottom distal portion to the leading edge.
4. The insertion system of claim 1, 2, or 3, wherein the leading edge is semicircular.
5. The insertion system of any one of claims 1 to 4, further comprising a bottom slot through the bottom distal portion of the elongated body.
6. The insertion system of claim 5, wherein the bottom slot extends to the leading edge of the elongated body and is substantially aligned with the slot through the top distal portion.
7. The insertion system of any one of claims 1 to 6, wherein the elongated body is made from a single piece of material.
8. The insertion system of claim 7, wherein the material comprises titanium.
9. The insertion system of any one of claims 1 to 8, wherein the elongated body has a bend proximal the distal end.
10. The insertion system of claim 9, wherein the bend of the elongated body is contoured to follow the curvature of a patient's cornea.
11. The insertion system of claim 9, wherein the bend is a first bend, and the elongated body also has a second bent portion proximal to the first bend.
12. The insertion system of any one of claims 1 to 11, wherein the corneal implant has a diameter of between 1 mm and 7 mm.
13. The insertion system of claim 12, wherein the holding space has a width that is no more than 20 percent larger than a diameter of the corneal implant.
14. The insertion system of any one of claims 1 to 13, further comprising a cap placed on the distal end of the elongated body, wherein the cap substantially encloses the holding space of the elongated body.
15. The insertion system of claim 14, further comprising a storage container at least partially filled with the fluid, wherein the cap and the holding space of the elongated body are submerged in the fluid.
16. The insertion system of claim 15, wherein the fluid comprises saline.
17. The system of any one of claims 1 to 16, wherein the generally flat top distal portion and the generally flat bottom distal portion are substantially parallel.
18. The system of claim 17, wherein the corneal implant has an anterior surface and a posterior surface, and wherein the corneal implant is held in the holding space such that the anterior surface is adjacent the top distal portion and the posterior surface is adjacent the bottom distal portion.
19. The system of any one of claims 1 to 18, wherein the holding space is also defined by a first side wall and a second side wall, wherein the first and second side walls have slots therein.
20. The system of any one of claims 1 to 19, further comprising an implant removal tool adapted to fit through the slot and engage the corneal implant in order to remove the corneal implant from the holding space.
21. A corneal inlay insertion system, comprising an elongate body comprising a holding space configured to retain a corneal inlay in an unstressed configuration due to the geometry of the holding space and surface tension, a distal port out of which the corneal inlay passes when deployed from the holding space, the distal port having a width greater than a diameter of the corneal inlay, and a fluid channel extending from the holding space to a proximal end of the elongate body to provide fluid communication from the proximal end to the holding space; and the corneal inlay retained at the holding space in an unstressed configuration, and wherein the holding space includes a top portion disposed on top of the corneal inlay, the top portion having a width that is greater than a diameter of the corneal inlay, and a bottom portion disposed below the corneal inlay, the bottom portion having a width that is greater than a diameter of the corneal inlay.
22. The corneal inlay insertion system of claim 21 further wherein the proximal end is configured to be secured to a fluid delivery device adapted to deliver fluid from the fluid delivery device, through the channel, and to the holding space to release the corneal inlay from the holding space.
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US11/692,835 US8162953B2 (en) | 2007-03-28 | 2007-03-28 | Insertion system for corneal implants |
PCT/US2008/058260 WO2008121649A1 (en) | 2007-03-28 | 2008-03-26 | Insertion system for corneal implants |
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Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0366607A (en) * | 1989-08-03 | 1991-03-22 | Rooman Kogyo:Kk | Product for hygiene of oral cavity |
US8668735B2 (en) * | 2000-09-12 | 2014-03-11 | Revision Optics, Inc. | Corneal implant storage and delivery devices |
AU2001289038B2 (en) | 2000-09-12 | 2006-05-18 | Revision Optics, Inc. | System for packaging and handling an implant and method of use |
US10835371B2 (en) | 2004-04-30 | 2020-11-17 | Rvo 2.0, Inc. | Small diameter corneal inlay methods |
US10555805B2 (en) | 2006-02-24 | 2020-02-11 | Rvo 2.0, Inc. | Anterior corneal shapes and methods of providing the shapes |
US8382744B2 (en) * | 2006-08-23 | 2013-02-26 | Szymon Suckewer | Method and device for cornea reshaping by intrastromal tissue removal |
US9549848B2 (en) | 2007-03-28 | 2017-01-24 | Revision Optics, Inc. | Corneal implant inserters and methods of use |
US9271828B2 (en) | 2007-03-28 | 2016-03-01 | Revision Optics, Inc. | Corneal implant retaining devices and methods of use |
US8162953B2 (en) | 2007-03-28 | 2012-04-24 | Revision Optics, Inc. | Insertion system for corneal implants |
US9539143B2 (en) | 2008-04-04 | 2017-01-10 | Revision Optics, Inc. | Methods of correcting vision |
JP2011516180A (en) | 2008-04-04 | 2011-05-26 | レヴィジオン・オプティックス・インコーポレーテッド | Corneal inlay design and method for correcting vision |
US8343214B2 (en) * | 2008-10-20 | 2013-01-01 | Cateract Innovations LLC | Apparatus for the treatment of cataract |
EP2332494A1 (en) * | 2009-12-09 | 2011-06-15 | Neoptics AG | Applicator for inserting lenses |
US8454687B2 (en) * | 2010-02-11 | 2013-06-04 | Presbitech, Inc. | Lens inserter apparatus and method |
US9010817B2 (en) * | 2010-02-12 | 2015-04-21 | Presbibio, Llc | Lens holder apparatus and system and method |
GB201011313D0 (en) * | 2010-07-05 | 2010-08-18 | Ucl Business Plc | Implantation devices, methods and implants |
US8469948B2 (en) * | 2010-08-23 | 2013-06-25 | Revision Optics, Inc. | Methods and devices for forming corneal channels |
US9186245B2 (en) * | 2011-09-07 | 2015-11-17 | Vladimir Feingold | Lens injector apparatus and method |
KR101762932B1 (en) | 2011-10-21 | 2017-08-04 | 리비젼 옵틱스, 인크. | Corneal implant storage and delivery devices |
WO2013082545A1 (en) | 2011-12-02 | 2013-06-06 | Acufocus, Inc. | Ocular mask having selective spectral transmission |
ES2529321T3 (en) * | 2012-07-06 | 2015-02-19 | Neoptics Ag | System for the insertion of an intracorneal lens |
US9204962B2 (en) | 2013-03-13 | 2015-12-08 | Acufocus, Inc. | In situ adjustable optical mask |
US9427922B2 (en) | 2013-03-14 | 2016-08-30 | Acufocus, Inc. | Process for manufacturing an intraocular lens with an embedded mask |
US10092393B2 (en) | 2013-03-14 | 2018-10-09 | Allotex, Inc. | Corneal implant systems and methods |
EP3073963A4 (en) * | 2013-11-27 | 2017-12-06 | PresbiBio. LLC | Lens inserter assembly |
US20150297344A1 (en) * | 2014-04-21 | 2015-10-22 | Arvind Saini | Irrigating intraocular lens rotators and related methods |
WO2016095884A1 (en) * | 2014-12-15 | 2016-06-23 | Geuder Ag | Device for supporting and transporting a graft or implant |
WO2016144404A1 (en) | 2015-03-12 | 2016-09-15 | Revision Optics, Inc. | Methods of correcting vision |
US10449090B2 (en) | 2015-07-31 | 2019-10-22 | Allotex, Inc. | Corneal implant systems and methods |
US20180325655A1 (en) * | 2015-11-11 | 2018-11-15 | Revision Optics, Inc. | Corneal device inserters and methods of use |
KR101713055B1 (en) * | 2016-10-27 | 2017-03-07 | 이동호 | Iris enlargement implants, surgical method and instruments for cosmetic eyeball surgery |
CN109481083B (en) | 2017-09-11 | 2021-06-01 | 财团法人工业技术研究院 | Implanting instrument |
US11850188B2 (en) | 2019-04-01 | 2023-12-26 | Amo Development, Llc | Corneal lenticule extraction tool |
KR102188950B1 (en) * | 2019-04-09 | 2020-12-09 | 정영택 | Tool for ophthalmic surgery supplied with perfusion fluid |
CN112451207B (en) * | 2020-12-10 | 2022-06-14 | 微智医疗器械有限公司 | Surgical instrument assembly for implanting a retinal implant |
Family Cites Families (348)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2714721A (en) | 1953-01-23 | 1955-08-09 | Jr William Stone | Artificial corneal implants |
US3091328A (en) | 1961-03-02 | 1963-05-28 | Priscilla A Leonardos | Contact lens remover and carrier |
US3168100A (en) | 1962-12-07 | 1965-02-02 | Alvido R Rich | Contact lens dipper assembly |
US3482906A (en) | 1965-10-04 | 1969-12-09 | David Volk | Aspheric corneal contact lens series |
US3379200A (en) | 1965-10-24 | 1968-04-23 | Ruth M. Pennell | Lens containtr |
US3343657A (en) | 1966-09-02 | 1967-09-26 | Reuben F Speshyock | Contact lens conditioning facility |
US3950315A (en) | 1971-06-11 | 1976-04-13 | E. I. Du Pont De Nemours And Company | Contact lens having an optimum combination of properties |
US3743337A (en) | 1971-07-26 | 1973-07-03 | E Crary | Contact lens inserter |
US3770113A (en) | 1972-03-03 | 1973-11-06 | Mcd Corp | Contact lens holder |
US3879076A (en) | 1973-12-27 | 1975-04-22 | Robert O Barnett | Method and apparatus for applying and removing a soft contact lens |
US4065816A (en) * | 1975-05-22 | 1978-01-03 | Philip Nicholas Sawyer | Surgical method of using a sterile packaged prosthesis |
US3996627A (en) | 1975-09-22 | 1976-12-14 | American Optical Corporation | Artificial intraocular lens |
US4037604A (en) | 1976-01-05 | 1977-07-26 | Newkirk John B | Artifical biological drainage device |
US4030480A (en) | 1976-05-13 | 1977-06-21 | Ernst Jochen Meyer | Ocular decompression process |
US4039827A (en) | 1976-08-26 | 1977-08-02 | American Optical Corporation | Method for marking intraocular lenses |
US4071272A (en) | 1976-09-27 | 1978-01-31 | Drdlik Frank J | Contact lens applicator |
US4136406A (en) * | 1977-07-20 | 1979-01-30 | Norris John W | Intraocular lens with attached disposable instrument |
US4093291A (en) | 1977-08-17 | 1978-06-06 | Schurgin Herbert L | Contact lens application and removal instrument |
US4157718A (en) | 1977-08-31 | 1979-06-12 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Intra-ocular pressure normalization technique and equipment |
US4184491A (en) | 1977-08-31 | 1980-01-22 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Intra-ocular pressure normalization technique and equipment |
US4194814A (en) | 1977-11-10 | 1980-03-25 | Bausch & Lomb Incorporated | Transparent opthalmic lens having engraved surface indicia |
US4238524A (en) | 1978-03-06 | 1980-12-09 | American Optical Corporation | Process for identification marking clear plastic articles |
US4268133A (en) | 1978-07-14 | 1981-05-19 | Bausch & Lomb Incorporated | Preferential orientation of contact lenses |
US4392569A (en) | 1979-06-06 | 1983-07-12 | Shoup Leo E | Soft contact lens asepticizing case |
US4418991A (en) | 1979-09-24 | 1983-12-06 | Breger Joseph L | Presbyopic contact lens |
US4257521A (en) | 1979-11-16 | 1981-03-24 | Stanley Poler | Packaging means for an intraocular lens |
US4709697A (en) | 1980-12-09 | 1987-12-01 | Joseph J. Berke | Tissue pneumatic separator structure and method |
US4357940A (en) | 1979-12-13 | 1982-11-09 | Detroit Neurosurgical Foundation | Tissue pneumatic separator structure |
US5022414A (en) | 1979-12-13 | 1991-06-11 | Joseph J. Berke | Tissue separator method |
DE3169818D1 (en) | 1980-08-05 | 1985-05-15 | Choyce David P | Intraocular lens |
US4326306A (en) | 1980-12-16 | 1982-04-27 | Lynell Medical Technology, Inc. | Intraocular lens and manipulating tool therefor |
US4428746A (en) | 1981-07-29 | 1984-01-31 | Antonio Mendez | Glaucoma treatment device |
US5188125A (en) | 1982-01-04 | 1993-02-23 | Keravision, Inc. | Method for corneal curvature adjustment |
US4766895A (en) | 1982-01-04 | 1988-08-30 | Kera Corneal Devices, Inc. | Apparatus for corneal curvature adjustment |
US4671276A (en) | 1982-01-04 | 1987-06-09 | Kera Associates | Apparatus for corneal curvature adjustment |
US4452235A (en) | 1982-01-04 | 1984-06-05 | Reynolds Alvin E | Method for corneal curvature adjustment |
US4490860A (en) | 1982-01-18 | 1985-01-01 | Ioptex Inc. | Intraocular lens apparatus and method for implantation of same |
US4702244A (en) | 1982-02-05 | 1987-10-27 | Staar Surgical Company | Surgical device for implantation of a deformable intraocular lens |
US4423809A (en) | 1982-02-05 | 1984-01-03 | Staar Surgical Company, Inc. | Packaging system for intraocular lens structures |
DE3208729A1 (en) | 1982-03-11 | 1983-09-22 | Jörg Dr.med. 4630 Bochum Krumeich | Plastic lens |
US4545478A (en) | 1982-07-08 | 1985-10-08 | Fred Waldman | Hard contact lens suction cups and method for their production |
US4554918A (en) | 1982-07-28 | 1985-11-26 | White Thomas C | Ocular pressure relief device |
US4504982A (en) | 1982-08-05 | 1985-03-19 | Optical Radiation Corporation | Aspheric intraocular lens |
US4619256A (en) | 1982-09-08 | 1986-10-28 | Gerald Horn | Intraocular lens inserting assembly |
US4466705A (en) | 1982-09-30 | 1984-08-21 | Michelson Paul E | Fluid lens |
US4521210A (en) | 1982-12-27 | 1985-06-04 | Wong Vernon G | Eye implant for relieving glaucoma, and device and method for use therewith |
US4616910A (en) | 1983-03-01 | 1986-10-14 | Klein Robert E | Visual indicator on soft contact lenses |
US4580882A (en) | 1983-04-21 | 1986-04-08 | Benjamin Nuchman | Continuously variable contact lens |
US4525044A (en) | 1983-05-05 | 1985-06-25 | Bauman Robert C | Soft contact lens with surface identification and method of using same |
US4554115A (en) | 1983-08-30 | 1985-11-19 | Neefe Charles W | Method of controlling the convex curve of soft lenses |
US4618227A (en) | 1983-10-07 | 1986-10-21 | Vistakon, Inc. | Soft contact lens |
US4721124A (en) | 1983-12-01 | 1988-01-26 | Barry Tuerkheimer | Optometric soft and rigid contact lens cleaning and storage system |
US4565198A (en) | 1983-12-27 | 1986-01-21 | Barnes-Hind, Inc. | Method for altering the curvature of the cornea |
US4586929A (en) | 1984-04-06 | 1986-05-06 | Binder Perry S | Hydrogel keratoprosthesis |
US4640595A (en) | 1984-05-02 | 1987-02-03 | David Volk | Aspheric contact lens |
US4971732A (en) | 1984-06-28 | 1990-11-20 | Ceskoslovenska Academie Ved | Method of molding an intraocular lens |
DE3433581C2 (en) | 1984-09-13 | 1986-08-07 | Fa. Carl Zeiss, 7920 Heidenheim | Device for laminating, refractive corneal surgery |
US4624669A (en) | 1984-09-26 | 1986-11-25 | Surgidev Corporation | Corneal inlay with holes |
US4604087A (en) | 1985-02-26 | 1986-08-05 | Joseph Neil H | Aqueous humor drainage device |
US4646720A (en) | 1985-03-12 | 1987-03-03 | Peyman Gholam A | Optical assembly permanently attached to the cornea |
JPH0678460B2 (en) | 1985-05-01 | 1994-10-05 | 株式会社バイオマテリアル・ユニバース | Porous transparent polyvinyl alcohol gel |
US4624664A (en) | 1985-07-22 | 1986-11-25 | Travenol European Research And Development Centre (Teradec) | Antibacterial closure system |
US6264648B1 (en) | 1985-07-29 | 2001-07-24 | Bausch & Lomb Incorporated | Corneal curvature modification via internal ablation |
US4726367A (en) * | 1985-08-19 | 1988-02-23 | Shoemaker David W | Surgical instrument for implanting an intraocular lens |
GB2185124B (en) | 1986-01-03 | 1989-10-25 | Choyce David P | Intra-corneal implant |
NZ215409A (en) | 1986-03-07 | 1989-02-24 | Anthony Christopher Be Molteno | Implant for drainage of aqueous humour in glaucoma |
US5030230A (en) | 1986-05-16 | 1991-07-09 | Great Plains Eye Clinic, Ltd. | Corneal implant |
US5139518A (en) | 1986-05-16 | 1992-08-18 | White Thomas C | Methods employed in replacement of the corneal endothelium |
US4772283A (en) | 1986-05-16 | 1988-09-20 | White Thomas C | Corneal implant |
CS263203B1 (en) | 1986-07-22 | 1989-04-14 | Sulc Jiri | Soft intraocular lenses |
US5019084A (en) | 1986-08-06 | 1991-05-28 | Minnesota Mining And Manufacturing Company | Corneal holder |
US4697697A (en) | 1986-08-18 | 1987-10-06 | Coopervision, Inc. | Method and apparatus for packaging an intraocular lens |
US4676792A (en) | 1986-08-26 | 1987-06-30 | Donald Praeger | Method and artificial intraocular lens device for the phakic treatment of myopia |
US5114627A (en) | 1986-10-16 | 1992-05-19 | Cbs Lens | Method for producing a collagen hydrogel |
US5112350A (en) | 1986-10-16 | 1992-05-12 | Cbs Lens, A California General Partnership | Method for locating on a cornea an artificial lens fabricated from a collagen-hydrogel for promoting epithelial cell growth and regeneration of the stroma |
US4842599A (en) | 1986-10-28 | 1989-06-27 | Ann M. Bronstein | Prosthetic cornea and method of implantation therefor |
US4919130A (en) | 1986-11-07 | 1990-04-24 | Nestle S.A. | Tool for inserting compressible intraocular lenses into the eye and method |
US4897981A (en) | 1986-12-24 | 1990-02-06 | Alcon Laboratories, Inc. | Method of packaging intraocular lenses and contact lenses |
US4840175A (en) | 1986-12-24 | 1989-06-20 | Peyman Gholam A | Method for modifying corneal curvature |
US4762496A (en) | 1987-02-13 | 1988-08-09 | William F. Maloney | Ophthalmologic lens phantom system |
US4806382A (en) | 1987-04-10 | 1989-02-21 | University Of Florida | Ocular implants and methods for their manufacture |
US5244799A (en) | 1987-05-20 | 1993-09-14 | Anderson David M | Preparation of a polymeric hydrogel containing micropores and macropores for use as a cell culture substrate |
US5270744A (en) | 1987-06-01 | 1993-12-14 | Valdemar Portney | Multifocal ophthalmic lens |
US5225858A (en) | 1987-06-01 | 1993-07-06 | Valdemar Portney | Multifocal ophthalmic lens |
US4769033A (en) | 1987-07-02 | 1988-09-06 | Nordan Lee T | Intraocular multifocal lens |
US5282851A (en) | 1987-07-07 | 1994-02-01 | Jacob Labarre Jean | Intraocular prostheses |
US4886488A (en) | 1987-08-06 | 1989-12-12 | White Thomas C | Glaucoma drainage the lacrimal system and method |
US4798609A (en) | 1987-08-24 | 1989-01-17 | Grendahl Dennis T | Radially segmented zone of focus artificial lens |
US4778462A (en) | 1987-08-24 | 1988-10-18 | Grendahl Dennis T | Multiple element zone of focus artificial lens |
US4844242A (en) | 1987-09-02 | 1989-07-04 | The Johns Hopkins University | Cornea retainer |
EP0308077A3 (en) | 1987-09-14 | 1990-05-30 | Nestle S.A. | Synthetic intracorneal lens |
US4934363A (en) | 1987-12-15 | 1990-06-19 | Iolab Corporation | Lens insertion instrument |
US4851003A (en) | 1988-01-05 | 1989-07-25 | Lindstrom Richard L | Corneal implant lens with fixation holes |
US4888016A (en) | 1988-02-10 | 1989-12-19 | Langerman David W | "Spare parts" for use in ophthalmic surgical procedures |
US5108428A (en) | 1988-03-02 | 1992-04-28 | Minnesota Mining And Manufacturing Company | Corneal implants and manufacture and use thereof |
US4923467A (en) | 1988-03-02 | 1990-05-08 | Thompson Keith P | Apparatus and process for application and adjustable reprofiling of synthetic lenticules for vision correction |
US4836201A (en) | 1988-03-24 | 1989-06-06 | Patton Medical Technologies, Inc. | "Envelope" apparatus for inserting intra-ocular lens into the eye |
US4936825A (en) | 1988-04-11 | 1990-06-26 | Ungerleider Bruce A | Method for reducing intraocular pressure caused by glaucoma |
US4860885A (en) | 1988-04-29 | 1989-08-29 | Allergan, Inc. | Lens storage system |
US5273750A (en) | 1988-05-02 | 1993-12-28 | Institute National De La Sante Et De La Recherche Medicale- Inserm | Uncrosslinked hydrogel, process for its preparation and its uses as an article for medical and/or surgical purposes such as tubes, films, joints, implants and the like, particularly in ophthalmology |
US5211660A (en) | 1988-05-02 | 1993-05-18 | University Of South Florida | Method for performing epikeratophakia by electrofusion |
US5192317A (en) | 1988-07-26 | 1993-03-09 | Irvin Kalb | Multi focal intra-ocular lens |
US5785674A (en) | 1988-10-07 | 1998-07-28 | Mateen; Ahmed Abdul | Device and method for treating glaucoma |
US4976719A (en) | 1988-11-21 | 1990-12-11 | Siepser Steven B | Device used to change corneal curvature |
FR2647227B1 (en) | 1989-05-19 | 1991-08-23 | Essilor Int | OPTICAL COMPONENT, SUCH AS AN INTRAOCULAR IMPLANT OR CONTACT LENS, SUITABLE FOR CORRECTING THE VISION OF AN INDIVIDUAL |
US4911715A (en) | 1989-06-05 | 1990-03-27 | Kelman Charles D | Overlapping two piece intraocular lens |
SG49267A1 (en) * | 1989-08-14 | 1998-05-18 | Photogenesis Inc | Surgical instrument and cell isolation and transplantation |
EP0420549A3 (en) | 1989-09-25 | 1991-06-12 | Kingston Technologies, Inc. | Corneal lens implant |
US4946436A (en) | 1989-11-17 | 1990-08-07 | Smith Stewart G | Pressure-relieving device and process for implanting |
US5063942A (en) | 1989-12-14 | 1991-11-12 | Corneal Contouring, Inc. | Method for surgically re-profiling the cornea |
US5591185A (en) | 1989-12-14 | 1997-01-07 | Corneal Contouring Development L.L.C. | Method and apparatus for reprofiling or smoothing the anterior or stromal cornea by scraping |
US5318044A (en) | 1989-12-14 | 1994-06-07 | Corneal Contouring, Inc. | Method and apparatus for re-profiling the cornea to correct for hyperopia |
US4968296A (en) | 1989-12-20 | 1990-11-06 | Robert Ritch | Transscleral drainage implant device for the treatment of glaucoma |
US5092837A (en) | 1989-12-20 | 1992-03-03 | Robert Ritch | Method for the treatment of glaucoma |
US5073163A (en) | 1990-01-29 | 1991-12-17 | Lippman Myron E | Apparatus for treating glaucoma |
US5098444A (en) | 1990-03-16 | 1992-03-24 | Feaster Fred T | Epiphakic intraocular lens and process of implantation |
US5180362A (en) | 1990-04-03 | 1993-01-19 | Worst J G F | Gonio seton |
US5181053A (en) | 1990-05-10 | 1993-01-19 | Contact Lens Corporation Of America | Multi-focal contact lens |
US5041081A (en) | 1990-05-18 | 1991-08-20 | Odrich Ronald B | Ocular implant for controlling glaucoma |
US5397300A (en) | 1990-05-31 | 1995-03-14 | Iovision, Inc. | Glaucoma implant |
US5178604A (en) | 1990-05-31 | 1993-01-12 | Iovision, Inc. | Glaucoma implant |
US5476445A (en) | 1990-05-31 | 1995-12-19 | Iovision, Inc. | Glaucoma implant with a temporary flow restricting seal |
US5634943A (en) | 1990-07-12 | 1997-06-03 | University Of Miami | Injectable polyethylene oxide gel implant and method for production |
US5229797A (en) | 1990-08-08 | 1993-07-20 | Minnesota Mining And Manufacturing Company | Multifocal diffractive ophthalmic lenses |
US5173723A (en) | 1990-10-02 | 1992-12-22 | Volk Donald A | Aspheric ophthalmic accommodating lens design for intraocular lens and contact lens |
EP0507933B1 (en) | 1990-10-31 | 1996-05-22 | Baxter International Inc. | Close vascularization implant material |
US5071276A (en) | 1991-01-04 | 1991-12-10 | Abbott Laboratories | Contact lens cleaning system |
CA2103705C (en) | 1991-02-11 | 1996-01-30 | Ayub K. Ommaya | Spinal fluid driven artificial organ |
US5454796A (en) | 1991-04-09 | 1995-10-03 | Hood Laboratories | Device and method for controlling intraocular fluid pressure |
US5300020A (en) | 1991-05-31 | 1994-04-05 | Medflex Corporation | Surgically implantable device for glaucoma relief |
US5123905A (en) | 1991-06-07 | 1992-06-23 | Kelman Charles D | Intraocular lens injector |
US5512220A (en) | 1991-07-10 | 1996-04-30 | Johnson & Johnson Vision Products, Inc. | Method of making a clear axis, segmented multifocal ophthalmic lens |
US5312413A (en) * | 1991-07-17 | 1994-05-17 | Eaton Alexander M | Instrumentation for ophthalmic surgery and method of using the same |
US5171213A (en) | 1991-08-14 | 1992-12-15 | Price Jr Francis W | Technique for fistulization of the eye and an eye filtration prosthesis useful therefor |
US5428412B1 (en) | 1991-08-23 | 2000-08-08 | Contex Inc | Method for treating myopia with an aspheric corneal contact lens |
US5196026A (en) | 1991-09-16 | 1993-03-23 | Chiron Ophthalmics, Inc. | Method of implanting corneal inlay lenses smaller than the optic zone |
US6325792B1 (en) | 1991-11-06 | 2001-12-04 | Casimir A. Swinger | Ophthalmic surgical laser and method |
US5258042A (en) | 1991-12-16 | 1993-11-02 | Henry Ford Health System | Intravascular hydrogel implant |
EP0619724B1 (en) | 1992-01-02 | 2000-02-09 | BAUSCH & LOMB SURGICAL, INC. | Corneal ring inlay |
SG49160A1 (en) | 1992-01-14 | 1998-05-18 | Keravision Inc | Method for corneal curvature variation |
US5190552A (en) | 1992-02-04 | 1993-03-02 | Kelman Charles D | Slotted tube injector for an intraocular lens |
US5344448A (en) | 1992-02-11 | 1994-09-06 | Schneider Richard T | Multi-focal intra-ocular implant |
US5346464A (en) | 1992-03-10 | 1994-09-13 | Camras Carl B | Method and apparatus for reducing intraocular pressure |
AU650156B2 (en) | 1992-08-05 | 1994-06-09 | Lions Eye Institute Limited | Keratoprosthesis and method of producing the same |
DE69324811T2 (en) | 1992-08-07 | 1999-09-16 | Keravision Inc | INTRASTROMAL CORNAL RING |
US5944752A (en) | 1992-09-03 | 1999-08-31 | Kera Vision, Inc. | Astigmatic correcting intrastromal corneal insert |
US5405384A (en) | 1992-09-03 | 1995-04-11 | Keravision, Inc. | Astigmatic correcting intrastromal corneal ring |
US5318046A (en) | 1992-09-23 | 1994-06-07 | Rozakis George W | Method for corneal reprofiling |
US5755786A (en) | 1992-09-28 | 1998-05-26 | Iolab Corporation | Ophthalmic lens with reduced edge glare |
US5928245A (en) | 1992-09-30 | 1999-07-27 | Staar Surgical Company, Inc. | Deformable intraocular lens injecting apparatus with transverse hinged lens cartridge |
US6056757A (en) | 1992-09-30 | 2000-05-02 | Staar Surgical Company, Inc. | Implantation device with deformable nozzle tip for implanting a deformable intraocular lens |
US5616148A (en) | 1992-09-30 | 1997-04-01 | Staar Surgical Company, Inc. | Transverse hinged deformable intraocular lens injecting apparatus |
US5620450A (en) | 1992-09-30 | 1997-04-15 | Staar Surgical Company, Inc. | Transverse hinged deformable intraocular lens injecting apparatus |
US6712848B1 (en) | 1992-09-30 | 2004-03-30 | Staar Surgical Company, Inc. | Deformable intraocular lens injecting apparatus with transverse hinged lens cartridge |
US6022358A (en) | 1992-09-30 | 2000-02-08 | Staar Surgical Company, Inc. | Deformable intraocular lens injecting device |
US5860984A (en) | 1992-09-30 | 1999-01-19 | Staar Surgical Company, Inc. | Spring biased deformable intraocular injecting apparatus |
US5370607A (en) | 1992-10-28 | 1994-12-06 | Annuit Coeptis, Inc. | Glaucoma implant device and method for implanting same |
US5872613A (en) | 1992-11-23 | 1999-02-16 | Innotech, Inc. | Method of manufacturing contact lenses |
US5406341A (en) | 1992-11-23 | 1995-04-11 | Innotech, Inc. | Toric single vision, spherical or aspheric bifocal, multifocal or progressive contact lenses and method of manufacturing |
US5338291A (en) | 1993-02-03 | 1994-08-16 | Pudenz-Schulte Medical Research Corporation | Glaucoma shunt and method for draining aqueous humor |
FR2701770B1 (en) | 1993-02-18 | 1995-05-12 | Essilor Int | Simultaneous vision ophthalmic lens for the correction of presbyopia and set of two such ophthalmic lenses for the same wearer. |
US6090141A (en) | 1993-03-05 | 2000-07-18 | Lindstrom; Richard L. | Small intracorneal lens |
US5653715A (en) | 1993-03-09 | 1997-08-05 | Chiron Vision Corporation | Apparatus for preparing an intraocular lens for insertion |
US5493350A (en) | 1993-03-31 | 1996-02-20 | Seidner; Leonard | Multipocal contact lens and method for preparing |
US5467149A (en) | 1993-06-15 | 1995-11-14 | Bausch & Lomb Incorporated | Highly visible markings for contact lenses |
US5468246A (en) | 1993-07-02 | 1995-11-21 | Iovision, Inc. | Intraocular lens injector |
EP0712301A4 (en) | 1993-08-02 | 1996-12-11 | Keravision Inc | Segmented preformed intrastromal corneal insert |
US5489301A (en) | 1993-09-03 | 1996-02-06 | Barber; John C. | Corneal prosthesis |
US5502518A (en) | 1993-09-09 | 1996-03-26 | Scient Optics Inc | Asymmetric aspheric contact lens |
WO1995013766A1 (en) | 1993-11-18 | 1995-05-26 | Allergan, Inc. | Deformable lens insertion apparatus |
TW257671B (en) | 1993-11-19 | 1995-09-21 | Ciba Geigy | |
CA2142558C (en) | 1994-02-17 | 2001-10-16 | George J. Woffinden | Ophthalmic lens with reduced edge glare |
US6197019B1 (en) | 1994-04-25 | 2001-03-06 | Gholam A. Peyman | Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
US5630810A (en) | 1994-05-06 | 1997-05-20 | Machat; Jeffery J. | Method of ophthalmological surgery |
US6302877B1 (en) | 1994-06-29 | 2001-10-16 | Luis Antonio Ruiz | Apparatus and method for performing presbyopia corrective surgery |
US5533997A (en) | 1994-06-29 | 1996-07-09 | Ruiz; Luis A. | Apparatus and method for performing presbyopia corrective surgery |
US5629577A (en) | 1994-07-15 | 1997-05-13 | Micro Medical Devices | Miniature linear motion actuator |
US5520631A (en) | 1994-07-22 | 1996-05-28 | Wound Healing Of Oklahoma | Method and apparatus for lowering the intraocular pressure of an eye |
US5755785A (en) | 1994-08-12 | 1998-05-26 | The University Of South Florida | Sutureless corneal transplantation method |
AU3735195A (en) | 1994-10-06 | 1996-05-02 | Vladimir Feingold | Intraocular contact lens and method of implantation |
US5433701A (en) | 1994-12-21 | 1995-07-18 | Rubinstein; Mark H. | Apparatus for reducing ocular pressure |
IL117335A (en) | 1995-03-02 | 2001-08-08 | Keravision Inc | Corneal implant for changing refractive properties |
US6110166A (en) | 1995-03-20 | 2000-08-29 | Escalon Medical Corporation | Method for corneal laser surgery |
TW393498B (en) | 1995-04-04 | 2000-06-11 | Novartis Ag | The preparation and use of Polysiloxane-comprising perfluoroalkyl ethers |
US5980549A (en) | 1995-07-13 | 1999-11-09 | Origin Medsystems, Inc. | Tissue separation cannula with dissection probe and method |
US5715031A (en) | 1995-05-04 | 1998-02-03 | Johnson & Johnson Vision Products, Inc. | Concentric aspheric multifocal lens designs |
US5929969A (en) | 1995-05-04 | 1999-07-27 | Johnson & Johnson Vision Products, Inc. | Multifocal ophthalmic lens |
US5682223A (en) | 1995-05-04 | 1997-10-28 | Johnson & Johnson Vision Products, Inc. | Multifocal lens designs with intermediate optical powers |
IL118064A0 (en) | 1995-05-04 | 1996-08-04 | Johnson & Johnson Vision Prod | Concentric annular ring lens designs for astigmatic presbyopes |
US5684560A (en) | 1995-05-04 | 1997-11-04 | Johnson & Johnson Vision Products, Inc. | Concentric ring single vision lens designs |
IL117937A0 (en) | 1995-05-04 | 1996-08-04 | Johnson & Johnson Vision Prod | Combined multifocal toric lens designs |
US6175754B1 (en) | 1995-06-07 | 2001-01-16 | Keravision, Inc. | Method and apparatus for measuring corneal incisions |
US6125294A (en) | 1995-06-07 | 2000-09-26 | Kera Vision Inc. | Method and apparatus for measuring corneal incisions |
US20040073303A1 (en) | 1995-06-07 | 2004-04-15 | Harry J. Macey | Radial intrastromal corneal insert and a method of insertion |
US5968065A (en) | 1995-07-13 | 1999-10-19 | Origin Medsystems, Inc. | Tissue separation cannula |
US5779711A (en) | 1995-07-27 | 1998-07-14 | Michiel S. Kritzinger | Corneal flap/cap elevator |
US5643276A (en) | 1995-10-10 | 1997-07-01 | Allergan | Apparatus and method for providing desired rotational orientation to an intraocular lens |
US6280470B1 (en) | 1995-10-20 | 2001-08-28 | Gholam A. Peyman | Intrastromal corneal modification |
US6551307B2 (en) | 2001-03-23 | 2003-04-22 | Gholam A. Peyman | Vision correction using intrastromal pocket and flap |
US5964748A (en) | 1995-10-20 | 1999-10-12 | Peyman; Gholam A. | Intrastromal corneal modification |
US6221067B1 (en) | 1995-10-20 | 2001-04-24 | Gholam A. Peyman | Corneal modification via implantation |
US5722971A (en) | 1995-10-20 | 1998-03-03 | Peyman; Gholam A. | Intrastromal corneal modification |
US20010027314A1 (en) | 1995-10-20 | 2001-10-04 | Peyman Gholam A. | Intrastromal corneal modification via laser |
US6989008B2 (en) | 2001-03-23 | 2006-01-24 | Minu Llc | Adjustable ablatable inlay |
US20050143717A1 (en) | 2001-04-27 | 2005-06-30 | Peyman Gholam A. | Method of treatment of refractive errors using subepithelial or intrastromal corneal inlay with bonding coating |
US5919185A (en) | 1997-04-25 | 1999-07-06 | Peyman; Gholam A. | Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
US5929968A (en) | 1995-11-01 | 1999-07-27 | Cotie; Robert L. | Scleral-corneal contact lens |
US6203538B1 (en) | 1995-11-03 | 2001-03-20 | Gholam A. Peyman | Intrastromal corneal modification |
US5817115A (en) | 1995-12-04 | 1998-10-06 | Chiron Vision Corporation | Apparatus for resecting corneal tissue |
US5728155A (en) | 1996-01-22 | 1998-03-17 | Quantum Solutions, Inc. | Adjustable intraocular lens |
US5722948A (en) | 1996-02-14 | 1998-03-03 | Gross; Fredric J. | Covering for an ocular device |
US5695513A (en) * | 1996-03-01 | 1997-12-09 | Metagen, Llc | Flexible cutting tool and methods for its use |
US5628794A (en) | 1996-03-08 | 1997-05-13 | Lindstrom; Richard L. | Multifocal corneal implant lens having a hydrogelo coating |
FR2746000B1 (en) | 1996-03-14 | 1998-06-12 | FLEXIBLE INTRAOCULAR IMPLANT AND SET OF SUCH IMPLANTS | |
US5766181A (en) | 1996-08-02 | 1998-06-16 | Staar Surgical Company, Inc. | Spring biased deformable intraocular injecting apparatus |
AUPO185796A0 (en) | 1996-08-26 | 1996-09-19 | Lions Eye Institute | Ocular socket prosthesis |
US6881197B1 (en) | 1996-10-25 | 2005-04-19 | Anamed, Inc. | Sutureless implantable device and method for treatment of glaucoma |
US6007510A (en) | 1996-10-25 | 1999-12-28 | Anamed, Inc. | Implantable devices and methods for controlling the flow of fluids within the body |
US6142969A (en) | 1996-10-25 | 2000-11-07 | Anamed, Inc. | Sutureless implantable device and method for treatment of glaucoma |
US5855604A (en) | 1996-12-09 | 1999-01-05 | Microoptix, Llc | Method and apparatus for adjusting corneal curvature using a solid filled corneal ring |
US5876439A (en) | 1996-12-09 | 1999-03-02 | Micooptix, Llc | Method and appartus for adjusting corneal curvature using a fluid-filled corneal ring |
US5733334A (en) | 1996-12-09 | 1998-03-31 | Microoptix | Method and apparatus for adjusting corneal curvature |
US6228114B1 (en) | 1997-04-01 | 2001-05-08 | Joseph Y. Lee | Adjustable corneal ring |
US6159241A (en) | 1997-04-01 | 2000-12-12 | Joseph Y. Lee | Method and apparatus for adjusting corneal curvature using multiple removable corneal implants |
ID20540A (en) | 1997-04-07 | 1999-01-07 | Bausch & Lomb | METHOD FOR UNTUYK IDENTIFY THE CHARACTERISTICS OF THE CONTACT LENS |
US6055990A (en) | 1997-04-21 | 2000-05-02 | Thompson; Keith P. | Polymerizing gel intrakeratophakia-PGI |
US5752928A (en) | 1997-07-14 | 1998-05-19 | Rdo Medical, Inc. | Glaucoma pressure regulator |
US5873889A (en) | 1997-08-08 | 1999-02-23 | Origin Medsystems, Inc. | Tissue separation cannula with dissection probe and method |
US5964776A (en) | 1997-09-24 | 1999-10-12 | Peyman; Gholam A. | Internal keratome apparatus and method for using the same to form a pocket/flap between layers of a live cornea |
US5941583A (en) | 1997-10-07 | 1999-08-24 | Raimondi; Kent | Contact lens insertion and manipulation assembly and method |
US6007578A (en) | 1997-10-08 | 1999-12-28 | Ras Holding Corp | Scleral prosthesis for treatment of presbyopia and other eye disorders |
WO1999021513A1 (en) | 1997-10-24 | 1999-05-06 | Tekia, Inc. | Ophthalmologic insertor apparatus and methods of use |
US6605093B1 (en) | 1997-10-24 | 2003-08-12 | Tekia, Inc. | Device and method for use with an ophthalmologic insertor apparatus |
US6033395A (en) | 1997-11-03 | 2000-03-07 | Peyman; Gholam A. | System and method for modifying a live cornea via laser ablation and mechanical erosion |
US6050999A (en) | 1997-12-18 | 2000-04-18 | Keravision, Inc. | Corneal implant introducer and method of use |
US20020055753A1 (en) | 1997-12-18 | 2002-05-09 | Thomas A. Silvestrini | Corneal implant methods and pliable implant therefor |
US5936704A (en) | 1997-12-22 | 1999-08-10 | Gabrielian; Grant | Marked contact lens bearing optical marking element |
AU731944B2 (en) | 1997-12-29 | 2001-04-05 | Duckworth & Kent Limited | Injectors for intraocular lenses |
US6428572B2 (en) | 1998-01-12 | 2002-08-06 | Menicon Co., Ltd. | Intraocular ring |
US6206919B1 (en) | 1998-01-14 | 2001-03-27 | Joseph Y. Lee | Method and apparatus to correct refractive errors using adjustable corneal arcuate segments |
US5921989A (en) | 1998-02-12 | 1999-07-13 | Allergan | Lens protector for intraocular lens inserter |
CA2306864C (en) | 1998-03-04 | 2012-05-15 | Visx, Incorporated | Systems for laser treatment of presbyopia using offset imaging |
US6024448A (en) | 1998-03-31 | 2000-02-15 | Johnson & Johnson Vision Products, Inc. | Contact lenses bearing identifying marks |
FR2777093B1 (en) | 1998-04-07 | 2000-06-23 | Essilor Int | METHOD FOR PRODUCING ANGULAR TOLERANCE MARK FOR AN ASTIGMATIC CORRECTIVE LENS, AND ASSOCIATED LENS |
US6371960B2 (en) | 1998-05-19 | 2002-04-16 | Bausch & Lomb Surgical, Inc. | Device for inserting a flexible intraocular lens |
US6010510A (en) | 1998-06-02 | 2000-01-04 | Alcon Laboratories, Inc. | Plunger |
US5947976A (en) | 1998-06-02 | 1999-09-07 | Alcon Laboratories, Inc. | Asymmetric intraocular lens injection cartridge |
US6143001A (en) | 1998-06-02 | 2000-11-07 | Alcon Laboratories, Inc. | Asymmetric intraocular lens injection cartridge |
US6183513B1 (en) | 1998-06-05 | 2001-02-06 | Bausch & Lomb Surgical, Inc. | Intraocular lens packaging system, method of producing, and method of using |
US5976150A (en) | 1998-08-25 | 1999-11-02 | Alcon Laboratories, Inc. | Intraocular lens injection system |
US6171324B1 (en) | 1998-09-30 | 2001-01-09 | Becton, Dickinson And Company | Marker for corneal incision |
US6120148A (en) | 1998-10-05 | 2000-09-19 | Bifocon Optics Gmbh | Diffractive lens |
US6197057B1 (en) | 1998-10-27 | 2001-03-06 | Gholam A. Peyman | Lens conversion system for teledioptic or difractive configurations |
US20020010510A1 (en) | 1998-11-04 | 2002-01-24 | Thomas A. Silvestrini | Variable modulus corneal implant and fabrication methods |
US6447520B1 (en) | 2001-03-19 | 2002-09-10 | Advanced Medical Optics, Inc. | IOL insertion apparatus with IOL engagement structure and method for using same |
US6329485B1 (en) | 1998-12-11 | 2001-12-11 | Bausch & Lomb Incorporated | High refractive index hydrogel compositions for ophthalmic implants |
WO2000036457A1 (en) | 1998-12-16 | 2000-06-22 | Wesley Jessen Corporation | Multifocal contact lens with aspheric surface |
US6102946A (en) | 1998-12-23 | 2000-08-15 | Anamed, Inc. | Corneal implant and method of manufacture |
US6626941B2 (en) | 1998-12-23 | 2003-09-30 | Anamed, Inc. | Corneal implant and method of manufacture |
US6361560B1 (en) | 1998-12-23 | 2002-03-26 | Anamed, Inc. | Corneal implant and method of manufacture |
DE19904220C2 (en) | 1999-02-03 | 2001-08-30 | Helmut Binder | Injector for folding and inserting an intraocular lens, and containers for storing and transporting the injector |
US6210005B1 (en) | 1999-02-04 | 2001-04-03 | Valdemar Portney | Multifocal ophthalmic lens with reduced halo size |
WO2000049058A1 (en) | 1999-02-18 | 2000-08-24 | Novartis Ag | New biomaterials |
US6554424B1 (en) | 1999-03-01 | 2003-04-29 | Boston Innovative Optices, Inc. | System and method for increasing the depth of focus of the human eye |
US6139560A (en) | 1999-03-16 | 2000-10-31 | Kremer; Frederic B. | Cutting device and method for making controlled surgical incisions |
US6197058B1 (en) | 1999-03-22 | 2001-03-06 | Valdemar Portney | Corrective intraocular lens system and intraocular lenses and lens handling device therefor |
US6129733A (en) | 1999-04-15 | 2000-10-10 | Allergan Sales, Inc. | Apparatus for holding intraocular lenses and injectors, and methods for using same |
WO2000064389A1 (en) | 1999-04-26 | 2000-11-02 | Lynch Mary G | Trabeculotomy device and method for treating glaucoma |
US6461384B1 (en) | 1999-06-17 | 2002-10-08 | Bausch & Lomb Incorporated | Intraocular lenses |
US6511178B1 (en) | 1999-07-19 | 2003-01-28 | Johnson & Johnson Vision Care, Inc. | Multifocal ophthalmic lenses and processes for their production |
US6248111B1 (en) | 1999-08-06 | 2001-06-19 | Allergan Sales, Inc. | IOL insertion apparatus and methods for using same |
US6325509B1 (en) | 1999-08-20 | 2001-12-04 | Art Optical Contact Lens, Inc. | Low-mass ophthalmic lens |
US6271281B1 (en) | 1999-08-26 | 2001-08-07 | Medennium, Inc. | Homopolymers containing stable elasticity inducing crosslinkers and ocular implants made therefrom |
US6645246B1 (en) | 1999-09-17 | 2003-11-11 | Advanced Medical Optics, Inc. | Intraocular lens with surrounded lens zone |
US6251114B1 (en) | 1999-10-29 | 2001-06-26 | Allergan Sales, Inc. | Rotatable IOL insertion apparatus and method for using same |
US6596000B2 (en) * | 1999-11-05 | 2003-07-22 | Alcon Universal Ltd. | Instrument for positioning an intracorneal optical lens |
US6250757B1 (en) | 1999-12-15 | 2001-06-26 | Johnson & Johnson Vision Products, Inc. | Hybrid refractive birefringent multifocal ophthalmic lenses |
US6589203B1 (en) | 2000-01-26 | 2003-07-08 | Peter Mitrev | Glaucoma drainage device implant |
US6391230B1 (en) | 2000-02-18 | 2002-05-21 | Bausch & Lomb Incorporated | Intraocular lens manufacturing process |
US6364483B1 (en) | 2000-02-22 | 2002-04-02 | Holo Or Ltd. | Simultaneous multifocal contact lens and method of utilizing same for treating visual disorders |
US7048759B2 (en) | 2000-02-24 | 2006-05-23 | Advanced Medical Optics, Inc. | Intraocular lenses |
US6283595B1 (en) | 2000-02-24 | 2001-09-04 | Joseph L. Breger | Pinhole presbyopic contact lenses |
US6458141B1 (en) | 2000-03-10 | 2002-10-01 | Gholam A. Peyman | Method and apparatus for creating a flap in the cornea and incisions or shrinkage under the flap to correct vision disorders |
US6436092B1 (en) | 2000-03-21 | 2002-08-20 | Gholam A. Peyman | Adjustable universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
US6949093B1 (en) | 2000-03-21 | 2005-09-27 | Minu, L.L.C. | Adjustable universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
US20040039401A1 (en) * | 2000-03-31 | 2004-02-26 | Chow Alan Y. | Implant instrument |
US6648877B1 (en) | 2000-06-30 | 2003-11-18 | Intralase Corp. | Method for custom corneal corrections |
US6544286B1 (en) | 2000-07-18 | 2003-04-08 | Tissue Engineering Refraction, Inc. | Pre-fabricated corneal tissue lens method of corneal overlay to correct vision |
US6582076B1 (en) | 2000-08-30 | 2003-06-24 | Johnson & Johnson Vision Care, Inc. | Ophthalmic lenses useful in correcting astigmatism and presbyopia |
US6474814B1 (en) | 2000-09-08 | 2002-11-05 | Florida Optical Engineering, Inc | Multifocal ophthalmic lens with induced aperture |
US6543610B1 (en) | 2000-09-12 | 2003-04-08 | Alok Nigam | System for packaging and handling an implant and method of use |
AU2001289038B2 (en) | 2000-09-12 | 2006-05-18 | Revision Optics, Inc. | System for packaging and handling an implant and method of use |
US6554425B1 (en) | 2000-10-17 | 2003-04-29 | Johnson & Johnson Vision Care, Inc. | Ophthalmic lenses for high order aberration correction and processes for production of the lenses |
US6398789B1 (en) | 2000-10-19 | 2002-06-04 | Alcon Universal, Ltd. | Intraocular lens injector cartridge |
US6666887B1 (en) | 2000-10-20 | 2003-12-23 | Thinoptx, Inc. | Deformable intraocular multi-focus lens |
US6471708B2 (en) | 2000-12-21 | 2002-10-29 | Bausch & Lomb Incorporated | Intraocular lens and additive packaging system |
JP2002303831A (en) | 2001-01-30 | 2002-10-18 | Menicon Co Ltd | Contact lens |
US6398277B1 (en) | 2001-03-15 | 2002-06-04 | Mcdonald Marguerite B. | Contact lens insertion device |
US6589280B1 (en) | 2001-05-11 | 2003-07-08 | Jeffrey E. Koziol | Method for producing a multifocal corneal surface using intracorneal microscopic lenses |
EP1408881A1 (en) | 2001-06-13 | 2004-04-21 | The Lions Eye Institute of Western Australia Incorporated | Improved keratoprosthesis |
US20030014042A1 (en) | 2001-07-13 | 2003-01-16 | Tibor Juhasz | Method of creating stromal pockets for corneal implants |
US20030078487A1 (en) | 2001-08-09 | 2003-04-24 | Jeffries Robert E. | Ocular pressure measuring device |
US6537283B2 (en) | 2001-08-17 | 2003-03-25 | Alcon, Inc. | Intraocular lens shipping case and injection cartridge |
US6623522B2 (en) | 2001-11-07 | 2003-09-23 | Alok Nigam | Myopic corneal ring with central accommodating portion |
US7153316B1 (en) | 2001-11-09 | 2006-12-26 | Mcdonald Marguerite B | Surgical instruments and method for corneal reformation |
US6786926B2 (en) | 2001-11-09 | 2004-09-07 | Minu, L.L.C. | Method and apparatus for alignment of intracorneal inlay |
US6879402B2 (en) | 2001-11-16 | 2005-04-12 | Zygo Corporation | Scanning interferometer for aspheric surfaces and wavefronts |
MXPA04006954A (en) | 2002-01-17 | 2005-03-23 | Perez Edward | Methods for producing epithelial flaps on the cornea and for placement of ocular devices and lenses beneath an epithelial flap or membrane, epithelial delaminating devices, and structures of epithelium and ocular devices and lenses. |
US6723104B2 (en) | 2002-03-13 | 2004-04-20 | Advanced Medical Optics, Inc. | IOL insertion apparatus and method for using same |
US20030229303A1 (en) | 2002-03-22 | 2003-12-11 | Haffner David S. | Expandable glaucoma implant and methods of use |
US6733507B2 (en) | 2002-04-12 | 2004-05-11 | Advanced Medical Optics, Inc. | Intraocular lens insertion apparatus |
US6733526B2 (en) | 2002-04-25 | 2004-05-11 | Advanced Medical Optics, Inc. | Method of improving adherence and centering of intra-corneal implants on corneal bed |
CA2485508C (en) | 2002-06-03 | 2012-07-31 | Scientific Optics, Inc. | Method and system for improving vision |
US6855163B2 (en) | 2002-07-19 | 2005-02-15 | Minu, Llc | Gradual correction of corneal refractive error using multiple inlays |
US20040019379A1 (en) | 2002-07-25 | 2004-01-29 | Advanced Medical Optics, Inc. | Intracorneal lens with flow enhancement area for increased nutrient transport |
US20040034413A1 (en) | 2002-08-13 | 2004-02-19 | Christensen James M. | Hydrogel corneal inlay |
WO2004024035A1 (en) | 2002-09-13 | 2004-03-25 | Ocular Sciences, Inc. | Devices and methods for improving vision |
US7018409B2 (en) | 2002-09-13 | 2006-03-28 | Advanced Medical Optics, Inc. | Accommodating intraocular lens assembly with aspheric optic design |
US6709103B1 (en) | 2002-10-31 | 2004-03-23 | Johnson & Johnson Vision Care, Inc. | Methods for designing multifocal ophthalmic lenses |
US6955432B2 (en) | 2003-04-03 | 2005-10-18 | Neil John Graham | Contact lens placement instrument |
JP2007503225A (en) | 2003-08-21 | 2007-02-22 | レビジョン オプティクス, インコーポレイテッド | Method for keratofacia surgery |
AU2004279406B2 (en) | 2003-10-06 | 2010-12-02 | Crs & Associates | Method and apparatus for enhanced corneal accommodation |
BRPI0508699A (en) | 2004-03-15 | 2007-08-21 | Visx Inc | method for stabilizing an amount of laser energy delivered to a target by a laser generating device; and method and system for performing a laser eye surgery procedure. |
US20080262610A1 (en) | 2007-04-20 | 2008-10-23 | Alan Lang | Biomechanical design of intracorneal inlays |
US8057541B2 (en) | 2006-02-24 | 2011-11-15 | Revision Optics, Inc. | Method of using small diameter intracorneal inlays to treat visual impairment |
US7776086B2 (en) | 2004-04-30 | 2010-08-17 | Revision Optics, Inc. | Aspherical corneal implant |
US20050246016A1 (en) | 2004-04-30 | 2005-11-03 | Intralens Vision, Inc. | Implantable lenses with modified edge regions |
US20110218623A1 (en) | 2004-04-30 | 2011-09-08 | Jon Dishler | Small Diameter Inlays |
US20060004381A1 (en) * | 2004-07-01 | 2006-01-05 | Vladimir Feingold | Intracorneal lens insertion device |
US20060020267A1 (en) | 2004-07-15 | 2006-01-26 | Marmo J C | Intrastromal devices and methods for improving vision |
US20060064112A1 (en) * | 2004-09-08 | 2006-03-23 | Edward Perez | Ocular device applicator |
US20060052796A1 (en) * | 2004-09-08 | 2006-03-09 | Edward Perez | Combined epithelial delaminator and inserter |
US20060116762A1 (en) | 2004-11-30 | 2006-06-01 | Xin Hong | Aspheric lenticule for keratophakia |
JP4766442B2 (en) * | 2004-12-28 | 2011-09-07 | Hoya株式会社 | Intraocular lens insertion device |
US20060142780A1 (en) | 2004-12-29 | 2006-06-29 | Joel Pynson | Preloaded IOL injector and method |
US20060142781A1 (en) | 2004-12-29 | 2006-06-29 | Joel Pynson | Preloaded IOL injector and method |
US20060173539A1 (en) | 2005-01-31 | 2006-08-03 | Yichieh Shiuey | Corneal implants and methods and systems for placement |
US20060235430A1 (en) | 2005-04-15 | 2006-10-19 | Intralens Vision, Inc. | Corneal implant injector assembly and methods of use |
MX2007013423A (en) * | 2005-04-27 | 2008-01-18 | Tissue Engineering Refraction Inc | Epithelial delaminating device (v) and blades useful in that device. |
US8088161B2 (en) | 2005-07-28 | 2012-01-03 | Visioncare Ophthalmic Technologies Inc. | Compressed haptics |
US20070129797A1 (en) | 2005-12-01 | 2007-06-07 | Revision Optics, Inc. | Intracorneal inlays |
EP1981437B1 (en) * | 2006-01-26 | 2016-05-25 | Wake Forest University Health Sciences | Corneal donor disc medical tool |
US20070255401A1 (en) | 2006-05-01 | 2007-11-01 | Revision Optics, Inc. | Design of Inlays With Intrinsic Diopter Power |
ITPC20060025A1 (en) | 2006-05-15 | 2007-11-16 | Claudio Malacuso | SURGICAL INSTRUMENT TO MANIPULATE AND INSERT A CELL LAMINA IN THE EYE, IN PARTICULAR A THIN SUPPORT OF STROMA WITH ENDOTHELIAL CELLS, FOR CORNEAL TRANSPLANT |
US20070280994A1 (en) | 2006-06-01 | 2007-12-06 | Cunanan Crystal M | Ocular Tissue Separation Areas With Barrier Regions For Inlays Or Other Refractive Procedures |
US8162953B2 (en) | 2007-03-28 | 2012-04-24 | Revision Optics, Inc. | Insertion system for corneal implants |
JP2011516180A (en) | 2008-04-04 | 2011-05-26 | レヴィジオン・オプティックス・インコーポレーテッド | Corneal inlay design and method for correcting vision |
US8469948B2 (en) | 2010-08-23 | 2013-06-25 | Revision Optics, Inc. | Methods and devices for forming corneal channels |
-
2007
- 2007-03-28 US US11/692,835 patent/US8162953B2/en not_active Expired - Fee Related
-
2008
- 2008-03-26 EP EP08732852A patent/EP2136745A1/en not_active Withdrawn
- 2008-03-26 JP JP2010501188A patent/JP5324561B2/en not_active Expired - Fee Related
- 2008-03-26 WO PCT/US2008/058260 patent/WO2008121649A1/en active Application Filing
- 2008-03-26 AU AU2008232842A patent/AU2008232842B2/en not_active Ceased
- 2008-03-26 CA CA2680070A patent/CA2680070C/en not_active Expired - Fee Related
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2013
- 2013-07-18 JP JP2013149315A patent/JP5881649B2/en not_active Expired - Fee Related
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- 2016-01-22 JP JP2016010591A patent/JP2016120303A/en active Pending
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US20080243138A1 (en) | 2008-10-02 |
JP5324561B2 (en) | 2013-10-23 |
JP2013230391A (en) | 2013-11-14 |
CA2680070A1 (en) | 2008-10-09 |
US20120165823A1 (en) | 2012-06-28 |
WO2008121649A1 (en) | 2008-10-09 |
JP2016120303A (en) | 2016-07-07 |
AU2008232842B2 (en) | 2013-01-24 |
JP5881649B2 (en) | 2016-03-09 |
US8540727B2 (en) | 2013-09-24 |
EP2136745A1 (en) | 2009-12-30 |
AU2008232842A1 (en) | 2008-10-09 |
JP2010522622A (en) | 2010-07-08 |
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