CA2689890A1 - Method of manufacturing an intracutaneous microneedle array - Google Patents

Method of manufacturing an intracutaneous microneedle array Download PDF

Info

Publication number
CA2689890A1
CA2689890A1 CA2689890A CA2689890A CA2689890A1 CA 2689890 A1 CA2689890 A1 CA 2689890A1 CA 2689890 A CA2689890 A CA 2689890A CA 2689890 A CA2689890 A CA 2689890A CA 2689890 A1 CA2689890 A1 CA 2689890A1
Authority
CA
Canada
Prior art keywords
microneedle array
photoresist material
plastic material
mold
mask layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2689890A
Other languages
French (fr)
Other versions
CA2689890C (en
Inventor
Faiz F. Sherman
Vadim Vladimirovich Yuzhakov
Vladimir Gartstein
Grover David Owens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corium Inc
Original Assignee
Corium International, Inc.
Faiz F. Sherman
Vadim Vladimirovich Yuzhakov
Vladimir Gartstein
Grover David Owens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corium International, Inc., Faiz F. Sherman, Vadim Vladimirovich Yuzhakov, Vladimir Gartstein, Grover David Owens filed Critical Corium International, Inc.
Priority claimed from CA002591168A external-priority patent/CA2591168C/en
Publication of CA2689890A1 publication Critical patent/CA2689890A1/en
Application granted granted Critical
Publication of CA2689890C publication Critical patent/CA2689890C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C51/00—Shaping by thermoforming, i.e. shaping sheets or sheet like preforms after heating, e.g. shaping sheets in matched moulds or by deep-drawing; Apparatus therefor
    • B29C51/08—Deep drawing or matched-mould forming, i.e. using mechanical means only
    • B29C51/082—Deep drawing or matched-mould forming, i.e. using mechanical means only by shaping between complementary mould parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
    • B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
    • B26F1/24—Perforating by needles or pins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/0033—Moulds or cores; Details thereof or accessories therefor constructed for making articles provided with holes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/42—Moulds or cores; Details thereof or accessories therefor characterised by the shape of the moulding surface, e.g. ribs or grooves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C37/00—Component parts, details, accessories or auxiliary operations, not covered by group B29C33/00 or B29C35/00
    • B29C37/0053—Moulding articles characterised by the shape of the surface, e.g. ribs, high polish
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/2628—Moulds with mould parts forming holes in or through the moulded article, e.g. for bearing cages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C51/00—Shaping by thermoforming, i.e. shaping sheets or sheet like preforms after heating, e.g. shaping sheets in matched moulds or by deep-drawing; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00111—Tips, pillars, i.e. raised structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
    • B29C59/022—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing characterised by the disposition or the configuration, e.g. dimensions, of the embossments or the shaping tools therefor
    • B29C2059/023—Microembossing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/03—Processes for manufacturing substrate-free structures
    • B81C2201/036—Hot embossing

Abstract

A microneedle array is manufactured using a mold preparation procedure that begins try placing an optical mask over a layer of PMMA material, exposing the PMMA
material to x-rays, then developing using a photoresist process. The remaining PMMA material is then electroplated with metal. Once the metal has reached an appropriate thickness, it is detached to become a metal mold that is used in a microembossing procedure, in which the metal mold is pressed against a heated layer of plastic material. Once the mold is pressed down to its proper distance, the plastic material is cooled until solidified, and the mold is then detached, thereby leaving behind an array of microneedles. If the microneedles are hollow, then an additional procedure is used to create through-holes all the way through the underlying substrate material using laser optical means.

Claims (5)

1. A method for preparing a mold for manufacturing a microneedle array, characterized by the steps of: providing a photoresist material, in contact with a temporary substrate; placing a mask layer upon said photoresist material, said mask layer having a predetermined pattern, at least a portion of said mask layer comprising a material that prevents high energy radiation from passing therethrough;
exposing said combination photoresist material/mask layer to high energy radiation;
removing said mask layer, and chemically developing exposed portions of said photo-resist material, thereby removing portions of the photoresist material and leaving behind a pattern of said photoresist material that represents a three-dimensional structure emulating a plurality of microneedles that are to be later formed;
electroplating said patterned photoresist material with a metallic substance; and detaching said metallic substance from said patterned photoresist material, said metallic substance thereby forming a microneedle array mold.
2. The method as recited in claim 1, wherein said photoresist material comprises polymethylmethacrylate (PMMA); or wherein said mask layer comprises gold; or wherein said electroplating metallic substrate comprises nickel.
3. The method as recited in claim 1, including the step of chemically coating said patterned photoresist material before the step of electroplating to aid in later detachment of the metallic substance from the patterned photoresist material.
4. The method as recited in claim 1, including the step of a microembossing procedure, comprising: placing a plastic material upon a temperature-controlled surface and, by use of said temperature-controlled surface, heating said plastic material to substantially its elastic working temperature, said plastic material having a first substantially planar surface touching said temperature-controlled surface and a second substantially planar surface on its opposite side;
pressing said microneedle array mold against the second substantially planar surface of said plastic material, thereby forming a three-dimensional pattern comprising a microneedle array in said plastic material; by use of said temperature-controlled surface, cooling said patterned plastic material below its deformable temperature; and de-molding, by removing said microneedle array mold from contact with said patterned plastic material, thereby leaving behind a plastic microneedle array; and preferably: wherein said plastic material comprises a biocompatible polymer.
5. The method as recited in claim 1, including the step of providing a vacuum during the molding process; or including the step of forming a fluid-holding chamber on the second substantially planar surface side of said patterned microneedle array.
CA2689890A 1999-06-09 2000-06-07 Method of manufacturing an intracutaneous microneedle array Expired - Fee Related CA2689890C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/328,946 1999-06-09
US09/328,946 US6312612B1 (en) 1999-06-09 1999-06-09 Apparatus and method for manufacturing an intracutaneous microneedle array
CA002591168A CA2591168C (en) 1999-06-09 2000-06-07 Method of manufacturing an intracutaneous microneedle array

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002591168A Division CA2591168C (en) 1999-06-09 2000-06-07 Method of manufacturing an intracutaneous microneedle array

Publications (2)

Publication Number Publication Date
CA2689890A1 true CA2689890A1 (en) 2000-12-14
CA2689890C CA2689890C (en) 2012-09-04

Family

ID=23283160

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002376283A Expired - Fee Related CA2376283C (en) 1999-06-09 2000-06-07 Method of manufacturing an intracutaneous microneedle array
CA2689890A Expired - Fee Related CA2689890C (en) 1999-06-09 2000-06-07 Method of manufacturing an intracutaneous microneedle array

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002376283A Expired - Fee Related CA2376283C (en) 1999-06-09 2000-06-07 Method of manufacturing an intracutaneous microneedle array

Country Status (7)

Country Link
US (3) US6312612B1 (en)
EP (1) EP1183064B1 (en)
JP (1) JP4436992B2 (en)
AU (1) AU5727900A (en)
CA (2) CA2376283C (en)
TW (1) TW512067B (en)
WO (1) WO2000074764A1 (en)

Families Citing this family (485)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US7344499B1 (en) * 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
WO2001036037A2 (en) * 1999-11-15 2001-05-25 Velcro Industries B.V. Skin attachment member
US6406638B1 (en) 2000-01-06 2002-06-18 The Regents Of The University Of California Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby
US6558361B1 (en) 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
JP3385364B2 (en) * 2000-05-17 2003-03-10 東京大学長 Method for manufacturing diamond cylinder array having concave portion
US6607673B2 (en) * 2000-05-17 2003-08-19 The University Of Tokyo Method for manufacturing a diamond cylinder array having dents therein
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US9717451B2 (en) * 2000-06-08 2017-08-01 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6607513B1 (en) * 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6540675B2 (en) * 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US6603987B2 (en) * 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
CA2424520C (en) * 2000-08-21 2007-01-02 The Cleveland Clinic Foundation Microneedle array module and method of fabricating the same
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7211209B2 (en) * 2000-11-08 2007-05-01 Surface Logix, Inc. Method of making device for arraying biomolecules and for monitoring cell motility in real-time
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6611308B2 (en) * 2000-11-30 2003-08-26 Hannstar Display Corp. Cone protrusion in multi-domain vertically aligned liquid crystal display
US7144495B2 (en) 2000-12-13 2006-12-05 Lifescan, Inc. Electrochemical test strip with an integrated micro-needle and associated methods
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US6620332B2 (en) * 2001-01-25 2003-09-16 Tecomet, Inc. Method for making a mesh-and-plate surgical implant
US7018418B2 (en) 2001-01-25 2006-03-28 Tecomet, Inc. Textured surface having undercut micro recesses in a surface
US6599322B1 (en) 2001-01-25 2003-07-29 Tecomet, Inc. Method for producing undercut micro recesses in a surface, a surgical implant made thereby, and method for fixing an implant to bone
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
AU2002252378B2 (en) 2001-03-19 2007-10-18 Intercell Usa, Inc. Transcutaneous immunostimulation
IL158480A0 (en) * 2001-04-20 2004-05-12 Alza Corp Microprojection array having a beneficial agent containing coating
US20020195417A1 (en) * 2001-04-20 2002-12-26 Steinberg Dan A. Wet and dry etching process on <110> silicon and resulting structures
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
EP1390085B1 (en) 2001-05-01 2009-08-05 A.V. Topchiev Institute of Petrochemical Synthesis Hydrogel compositions
EP1390084B1 (en) 2001-05-01 2011-03-23 A.V. Topchiev Institute of Petrochemical Synthesis Two-phase, water-absorbent bioadhesive composition
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US6855117B2 (en) 2001-08-01 2005-02-15 Johnson & Johnson Consumer Companies, Inc. Method of treating the skin of a subject
US6840910B2 (en) 2001-08-01 2005-01-11 Johnson & Johnson Consumer Companies, Inc. Method of distributing skin care products
US6790179B2 (en) 2001-08-01 2004-09-14 Johnson & Johnson Consumer Companies, Inc. Method of examining and diagnosing skin health
DE60213976T2 (en) * 2001-06-08 2007-04-26 Becton Dickinson And Co. DEVICE FOR MANIPULATING NEEDLES OR POLISHING ARRAY
US20020188310A1 (en) * 2001-06-08 2002-12-12 Seward Kirk Partick Microfabricated surgical device
US7127284B2 (en) * 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US7033371B2 (en) 2001-06-12 2006-04-25 Pelikan Technologies, Inc. Electric lancet actuator
AU2002312521A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
WO2002100254A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
WO2002100461A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP1404233B1 (en) 2001-06-12 2009-12-02 Pelikan Technologies Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US6767341B2 (en) * 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US7041257B2 (en) * 2001-09-25 2006-05-09 Cytonome, Inc. Microfabricated two-pin liquid sample dispensing system
US6686299B2 (en) * 2001-06-21 2004-02-03 Carlo D. Montemagno Nanosyringe array and method
US6749792B2 (en) * 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
US20030028087A1 (en) * 2001-08-01 2003-02-06 Yuzhakov Vadim Vladimirovich Devices for analyte concentration determination and methods of using the same
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US8201330B1 (en) * 2001-09-07 2012-06-19 Orbital Research Inc Physiological recording device or electrode
US7286864B1 (en) 2001-09-07 2007-10-23 Orbital Research, Inc. Dry physiological recording device
US6785569B2 (en) * 2001-09-07 2004-08-31 Orbital Research Dry physiological recording electrode
US6782283B2 (en) * 2001-09-07 2004-08-24 Robert N. Schmidt Dry penetrating recording device
DK1432466T3 (en) * 2001-09-12 2012-12-03 Becton Dickinson Co Micro needle-based pen dispenser for drug delivery and method of use thereof
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
WO2003024507A2 (en) * 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
AU2002330083A1 (en) * 2001-09-21 2003-04-01 Biovalve Technologies, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
CA2500452A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Switchable microneedle arrays and systems and methods relating to same
WO2003026733A2 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Microneedle with membrane
US20030093040A1 (en) * 2001-10-29 2003-05-15 Mikszta John A. Method and device for the delivery of a substance
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US7258839B2 (en) * 2001-12-21 2007-08-21 Cytonome, Inc. Temperature controlled microfabricated two-pin liquid sample dispensing system
US6908453B2 (en) 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US7051426B2 (en) * 2002-01-31 2006-05-30 Hewlett-Packard Development Company, L.P. Method making a cutting disk into of a substrate
US6911155B2 (en) * 2002-01-31 2005-06-28 Hewlett-Packard Development Company, L.P. Methods and systems for forming slots in a substrate
US20030140496A1 (en) * 2002-01-31 2003-07-31 Shen Buswell Methods and systems for forming slots in a semiconductor substrate
US20040060902A1 (en) * 2002-02-05 2004-04-01 Evans John D. Microprotrusion array and methods of making a microprotrusion
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US7387742B2 (en) * 2002-03-11 2008-06-17 Becton, Dickinson And Company Silicon blades for surgical and non-surgical use
BRPI0308319B1 (en) 2002-03-11 2015-06-09 Beaver Visitec Int Us Inc Method for making a crystalline material cutting device and method for making a surgical blade of crystalline material
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
US8116860B2 (en) * 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
WO2003077970A2 (en) * 2002-03-11 2003-09-25 Altea Therapeutics Corporation Transdermal integrated actuator device, methods of making and using same
US6716754B2 (en) * 2002-03-12 2004-04-06 Micron Technology, Inc. Methods of forming patterns and molds for semiconductor constructions
US20030186405A1 (en) * 2002-04-01 2003-10-02 The Ohio State University Research Foundation Micro/nano-embossing process and useful applications thereof
CN1547452A (en) * 2002-04-04 2004-11-17 ���µ�����ҵ��ʽ���� Lancet device
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US7060192B2 (en) 2002-05-09 2006-06-13 Lifescan, Inc. Methods of fabricating physiological sample collection devices
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
US6899838B2 (en) * 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
CN1691969A (en) * 2002-07-19 2005-11-02 3M创新有限公司 Microneedle devices and microneedle delivery apparatus
US7020508B2 (en) 2002-08-22 2006-03-28 Bodymedia, Inc. Apparatus for detecting human physiological and contextual information
AU2003268205B2 (en) * 2002-08-29 2010-02-18 Becton, Dickinson And Company Microabrader with controlled abrasion features
US6946362B2 (en) * 2002-09-06 2005-09-20 Hewlett-Packard Development Company, L.P. Method and apparatus for forming high surface area material films and membranes
US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
AU2003277306A1 (en) 2002-10-07 2004-05-04 Biovalve Technologies, Inc. Microneedle array patch
AU2003275491A1 (en) 2002-10-09 2004-05-04 Bodymedia, Inc. Method and apparatus for auto journaling of continuous or discrete body states utilizing physiological and/or contextual parameters
CA2444211C (en) * 2002-10-11 2013-11-19 Dermal Therapy (Barbados) Inc. Determination of biological conditions using impedance measurements
US6755984B2 (en) * 2002-10-24 2004-06-29 Hewlett-Packard Development Company, L.P. Micro-casted silicon carbide nano-imprinting stamp
US7045069B2 (en) 2002-11-14 2006-05-16 Gennady Ozeryansky Microfabrication method based on metal matrix composite technology
US6962772B2 (en) * 2002-12-27 2005-11-08 Industrial Technology Research Inst. Method for manufacturing 3-D high aspect-ratio microneedle array device
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
EP1615988A2 (en) * 2003-01-10 2006-01-18 Reveo, Inc. Highly controllable electroporation and applications thereof
KR100563330B1 (en) * 2003-01-16 2006-03-22 포스트마이크로 주식회사 Method for manufacturing of polymer micro needle array with liga process
US6821450B2 (en) * 2003-01-21 2004-11-23 Hewlett-Packard Development Company, L.P. Substrate and method of forming substrate for fluid ejection device
SE524340C2 (en) * 2003-01-22 2004-07-27 Tour & Andersson Ab Ways to make a membrane and membrane made according to the method
KR100562498B1 (en) * 2003-02-12 2006-03-21 삼성전자주식회사 Pad conditioner of cmp equipment
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
EP1602623B1 (en) * 2003-03-07 2011-08-17 Tosoh Corporation Method of moulding a microfluidic structure and mould
US20050155955A1 (en) * 2003-03-10 2005-07-21 Daskal Vadim M. Method for reducing glare and creating matte finish of controlled density on a silicon surface
US20090007436A1 (en) * 2003-03-10 2009-01-08 Daskal Vadim M Silicon blades for surgical and non-surgical use
CA2421832C (en) * 2003-03-13 2006-10-10 Bradley A. Saville Enhancement of enzyme activity by selective purification
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
US20040187661A1 (en) * 2003-03-25 2004-09-30 Obrachta Kevin L. Low penetration-force pinmat for perforating an uncured laminate sheet
US7347961B2 (en) 2003-04-01 2008-03-25 The Boeing Company Method and system having a flowable pressure pad for consolidating an uncured laminate sheet in a cure process
US20040195716A1 (en) * 2003-04-01 2004-10-07 Bergmann Blaise F. Method and system for utilizing low pressure for perforating and consolidating an uncured laminate sheet in one cycle of operation
US20060025717A1 (en) * 2003-04-18 2006-02-02 The Regents Of The University Of California Method for forming hollow out-of-plane microneedles and devices formed hereby
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
DE602004028463D1 (en) 2003-05-30 2010-09-16 Pelikan Technologies Inc METHOD AND DEVICE FOR INJECTING LIQUID
US7572405B2 (en) * 2003-06-02 2009-08-11 Corium International Inc. Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
JP2005021678A (en) * 2003-06-10 2005-01-27 Medorekkusu:Kk Pad base for percutaneous admistration and its manufacturing method
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
FR2857282B1 (en) * 2003-07-11 2006-08-18 Oreal DEVICE FOR APPLYING A PRODUCT AND ASSEMBLY FOR PACKAGING AND APPLYING A PRODUCT
US7708544B2 (en) * 2003-07-21 2010-05-04 10X Technology Llc Apparatus and method for manufacturing microneedles
US20050036004A1 (en) * 2003-08-13 2005-02-17 Barbara Horn Methods and systems for conditioning slotted substrates
EP1658035A4 (en) 2003-08-25 2007-08-22 3M Innovative Properties Co Delivery of immune response modifier compounds
EP1662970A2 (en) 2003-09-17 2006-06-07 Becton, Dickinson and Company System and method for creating linear and non-linear trenches in silicon and other crystalline materials with a router
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc Method and apparatus for a variable user interface
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
EP1740256A4 (en) * 2003-11-10 2011-06-29 Agency Science Tech & Res Microneedles and microneedle fabrication
US20080226699A1 (en) * 2003-11-28 2008-09-18 Acrux Dds Pty Ltd Method and System for Rapid Transdermal Administration
US8871224B2 (en) 2003-12-09 2014-10-28 Allergan, Inc. Botulinum toxin therapy for skin disorders
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
CN100355470C (en) * 2003-12-26 2007-12-19 中国科学院理化技术研究所 Minisize solid silicon needle array chip and its preparation method and use
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
US7241394B2 (en) * 2004-01-21 2007-07-10 Lumera Corporation Process of fabricating polymer sustained microelectrodes
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005074894A1 (en) 2004-01-30 2005-08-18 Corium International Rapidly dissolving film for delivery of an active agent
US8551391B2 (en) * 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
JP2007523771A (en) * 2004-02-23 2007-08-23 スリーエム イノベイティブ プロパティズ カンパニー Microneedle array molding method
EP1732640A4 (en) * 2004-03-12 2010-09-01 Agency Science Tech & Res Methods and moulds for use in fabricating side-ported microneedles
US20050203575A1 (en) * 2004-03-15 2005-09-15 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Skin microactivation system and method
US7611481B2 (en) 2004-03-24 2009-11-03 Corium International, Inc. Transdermal delivery device
ES2611284T3 (en) 2004-04-01 2017-05-08 The General Hospital Corporation Device for skin treatment and tissue remodeling
US20050220734A1 (en) * 2004-04-02 2005-10-06 Allergan, Inc. Therapy for melanin related afflictions
US8591436B2 (en) * 2004-04-30 2013-11-26 Roche Diagnostics Operations, Inc. Lancets for bodily fluid sampling supplied on a tape
US7909776B2 (en) * 2004-04-30 2011-03-22 Roche Diagnostics Operations, Inc. Lancets for bodily fluid sampling supplied on a tape
US7396484B2 (en) * 2004-04-30 2008-07-08 Becton, Dickinson And Company Methods of fabricating complex blade geometries from silicon wafers and strengthening blade geometries
US7591806B2 (en) * 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
EP1751546A2 (en) 2004-05-20 2007-02-14 Albatros Technologies GmbH &amp; Co. KG Printable hydrogel for biosensors
US7315758B2 (en) * 2004-06-03 2008-01-01 Lynntech, Inc. Transdermal delivery of therapeutic agent
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
EP1773444B1 (en) * 2004-06-10 2017-09-20 3M Innovative Properties Company Patch application device and kit
EP1616551A1 (en) 2004-07-13 2006-01-18 L'oreal Cosmetic treatment for preventing or delaying the signs of skin ageing
EP1778874B1 (en) 2004-07-30 2011-11-23 Adeza Biomedical Corporation Oncofetal fibronectin as a marker for cervical cancer
US7560036B2 (en) * 2004-08-05 2009-07-14 Apogee Technology, Inc. System and method for drug delivery and microfluidic applications using microneedles
MX2007001512A (en) 2004-08-05 2007-04-20 Corium Int Inc Adhesive composition.
ATE490037T1 (en) * 2004-08-16 2010-12-15 Functional Microstructures Ltd METHOD FOR PRODUCING A MICRONEEDLE OR A MICROIMPLANT
US20060058602A1 (en) * 2004-08-17 2006-03-16 Kwiatkowski Krzysztof C Interstitial fluid analyzer
US7316665B2 (en) * 2004-08-25 2008-01-08 Becton, Dickinson And Company Method and device for the delivery of a substance including a covering
SE0402100D0 (en) * 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
US7132054B1 (en) * 2004-09-08 2006-11-07 Sandia Corporation Method to fabricate hollow microneedle arrays
US20060073208A1 (en) 2004-10-01 2006-04-06 Allergan, Inc. Cosmetic neurotoxin compositions and methods
AU2005304912A1 (en) 2004-11-04 2006-05-18 Smith & Nephew, Inc. Cycle and load measurement device
EP1819379B1 (en) * 2004-11-18 2016-08-31 Nanopass Technologies Ltd. System for delivering fluid into flexible biological barrier
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
WO2006055795A1 (en) * 2004-11-18 2006-05-26 3M Innovative Properties Company Low-profile microneedle array applicator
CA2587387C (en) 2004-11-18 2013-06-25 3M Innovative Properties Company Method of contact coating a microneedle array
US7846488B2 (en) * 2004-11-18 2010-12-07 3M Innovative Properties Company Masking method for coating a microneedle array
JP5039559B2 (en) * 2004-11-26 2012-10-03 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ Fine structure manufacturing method and fine structure manufacturing apparatus
CN100528091C (en) * 2004-11-30 2009-08-19 苏州纳生微电子有限公司 Cosmetic skin needle, its manufacturing method and use
US20080009800A1 (en) * 2004-12-02 2008-01-10 Nickel Janice H Transdermal drug delivery device
ATE468961T1 (en) 2004-12-07 2010-06-15 3M Innovative Properties Co METHOD FOR SHAPING A MICRONEEDLE
FR2878745B1 (en) 2004-12-07 2007-03-09 Oreal TRANSUNGEAL DEVICE
US20060147423A1 (en) * 2004-12-07 2006-07-06 Jean-Yves Legendre Transungual device
BRPI0517501A (en) * 2004-12-10 2008-10-07 3M Innovative Properties Co medical device suitable for use in the administration of an active ingredient to or through the skin
CN100408126C (en) * 2004-12-13 2008-08-06 纳生微电子(苏州)有限公司 Preparing method for epidermis needle and its application
WO2006077742A1 (en) * 2004-12-28 2006-07-27 Nabtesco Corporation Skin needle producing device and skin needle producing method
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
JP4793806B2 (en) 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 Iontophoresis device
US20060216461A1 (en) * 2005-03-23 2006-09-28 Tachauer Ernesto S Molding touch fastener elements
CA2602259A1 (en) * 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
US7601284B2 (en) * 2005-04-06 2009-10-13 Velcro Industries B.V. Molding fastener elements on folded substrate
WO2006108185A1 (en) 2005-04-07 2006-10-12 3M Innovative Properties Company System and method for tool feedback sensing
WO2006124639A1 (en) * 2005-05-11 2006-11-23 Corium International, Inc. Permeabilization of biological membranes
JP5020080B2 (en) * 2005-05-13 2012-09-05 久光製薬株式会社 Manufacturing method of medical equipment
US7442029B2 (en) 2005-05-16 2008-10-28 Asml Netherlands B.V. Imprint lithography
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
SG128494A1 (en) * 2005-06-09 2007-01-30 Nanyang Polytechnic Polymeric microneedle array and apparatus and method for manufacturing of the same
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
JP4959151B2 (en) * 2005-06-14 2012-06-20 ナブテスコ株式会社 Method and apparatus for manufacturing skin needle
US20060283465A1 (en) * 2005-06-16 2006-12-21 Nickel Janice H Smart drug delivery system and a method of implementation thereof
WO2006138719A2 (en) 2005-06-17 2006-12-28 Georgia Tech Research Corporation Coated microstructures and method of manufacture thereof
EP1904158B1 (en) 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
DE602006016279D1 (en) 2005-06-27 2010-09-30 3M Innovative Properties Co MICRO NEEDLE CARTRIDGE ARRANGEMENT
AU2006261898B2 (en) * 2005-06-27 2011-11-03 3M Innovative Properties Company Microneedle array applicator device
JP2007014588A (en) * 2005-07-08 2007-01-25 Nano Device & System Research Inc Percutaneous administration apparatus, and mold for manufacturing percutaneous administration apparatus
JP2009502261A (en) * 2005-07-25 2009-01-29 ナノテクノロジー ビクトリア ピーティーワイ リミテッド Microarray device
JP5000866B2 (en) * 2005-08-01 2012-08-15 久光製薬株式会社 Non-toxic biopharmaceutical transport equipment
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
CA2620247C (en) 2005-08-23 2014-04-29 Smith & Nephew, Inc. Telemetric orthopaedic implant
JP4519037B2 (en) * 2005-08-31 2010-08-04 東京エレクトロン株式会社 Heating device and coating / developing device
CA2629393C (en) * 2005-09-06 2014-06-10 Theraject, Inc. Solid solution perforator containing drug particle and/or drug-adsorbed particles
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) * 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
JPWO2007032446A1 (en) 2005-09-15 2009-03-19 Ｔｔｉ・エルビュー株式会社 Rod iontophoresis device
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
WO2007038028A1 (en) * 2005-09-28 2007-04-05 Tti Ellebeau, Inc. Iontophoresis apparatus and method to deliver active agents to biological interfaces
CA2664589A1 (en) 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Iontophoretic device and method of delivery of active agents to biological interface
US20070093789A1 (en) * 2005-09-30 2007-04-26 Transcutaneous Technologies Inc. Iontophoresis apparatus and method for delivery of angiogenic factors to enhance healing of injured tissue
EP3461406A1 (en) 2005-09-30 2019-04-03 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
WO2007061964A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Methods for coating microneedles
US7842008B2 (en) 2005-11-21 2010-11-30 Becton, Dickinson And Company Intradermal delivery device
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US20070151920A1 (en) * 2005-12-06 2007-07-05 Kay Ronald J System and method of micromolded filtration microstructure and devices
US7651946B2 (en) * 2005-12-12 2010-01-26 University College Cork - National University Of Ireland, Cork Wet etch processing
US9636035B2 (en) * 2005-12-14 2017-05-02 Scibase Ab Medical apparatus for determination of biological conditions using impedance measurements
WO2007075614A1 (en) * 2005-12-21 2007-07-05 3M Innovative Properties Company Microneedle devices
EP1968777B1 (en) * 2005-12-23 2013-11-06 3M Innovative Properties Company Manufacturing microneedle arrays
WO2007079193A2 (en) 2005-12-30 2007-07-12 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
US7658728B2 (en) 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US20080306325A1 (en) 2006-10-02 2008-12-11 Emkinetics Method and apparatus for magnetic induction therapy
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
WO2011053607A1 (en) 2009-10-26 2011-05-05 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
EP1820441A1 (en) * 2006-02-16 2007-08-22 Roche Diagnostics GmbH Microneedle arrays with attenuated total reflection (ATR) sensor
US8858807B2 (en) * 2006-03-24 2014-10-14 3M Innovative Properties Company Process for making microneedles, microneedle arrays, masters, and replication tools
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US7491341B2 (en) * 2006-03-31 2009-02-17 Battelle Memorial Institute Method of making tapered capillary tips with constant inner diameters
WO2007124411A1 (en) 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
CN101074935B (en) * 2006-05-19 2011-03-23 清华大学 Detector array and its apparatus
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
US20070276330A1 (en) * 2006-05-28 2007-11-29 Beck Patricia A Microneedles and methods of fabricating thereof
US20070282246A1 (en) * 2006-06-05 2007-12-06 Mit, Llp Iontosonic-microneedle biosensor apparatus and methods
EP2047882B1 (en) 2006-07-27 2014-09-10 Toppan Printing Co., Ltd. Microneedle and method for producing microneedle
DE102006036331A1 (en) 2006-08-03 2008-02-14 Stephan Hammelbacher Device and method for marking objects
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
WO2008062832A1 (en) * 2006-11-22 2008-05-29 Toppan Printing Co., Ltd. Microneedle array and process for production thereof
US7785301B2 (en) * 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
TW200838576A (en) * 2006-12-01 2008-10-01 Transcu Ltd Systems, devices and methods for powering and/or controlling transdermal delivery devices
CN100460028C (en) * 2006-12-08 2009-02-11 中国科学院上海微系统与信息技术研究所 Miniature needle array for medicine transmission and its making process
FR2909552B1 (en) 2006-12-12 2009-11-20 Oreal COSMETIC USE OF ANISIC ACID TO PROMOTE DESQUACATION
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
WO2008091602A2 (en) 2007-01-22 2008-07-31 Corium International, Inc. Applicators for microneedle arrays
US9445720B2 (en) 2007-02-23 2016-09-20 Smith & Nephew, Inc. Processing sensed accelerometer data for determination of bone healing
US7713196B2 (en) * 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
US8560059B2 (en) * 2007-03-09 2013-10-15 Covidien Lp System and methods for optical sensing and drug delivery using microneedles
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
US20080251655A1 (en) * 2007-04-12 2008-10-16 Housley Todd B Bottle Holder
ES2817249T3 (en) 2007-04-16 2021-04-06 Corium Inc Microneedle matrices obtained by dissolution and casting containing an active principle
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
US7959969B2 (en) 2007-07-10 2011-06-14 California Institute Of Technology Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion
US20100121307A1 (en) * 2007-08-24 2010-05-13 Microfabrica Inc. Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications
JP4381438B2 (en) * 2007-09-05 2009-12-09 渡 渡邉 Drug sheet
ES2611597T3 (en) 2007-09-06 2017-05-09 Smith & Nephew, Inc. System and method to communicate with a telemetric implant
CN101808588B (en) * 2007-09-28 2012-12-19 贝尔法斯特女王大学 Delivery device and method
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
EP2247527A4 (en) 2008-02-07 2014-10-29 Univ Queensland Patch production
GB0802447D0 (en) * 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
US8425596B2 (en) * 2008-03-21 2013-04-23 Ut-Battelle, Llc Retinal instrument
US20090259118A1 (en) * 2008-03-31 2009-10-15 Abbott Diabetes Care Inc. Shallow Implantable Analyte Sensor with Rapid Physiological Response
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
US8452356B2 (en) * 2008-05-02 2013-05-28 Sri International Optical microneedle-based spectrometer
US9381680B2 (en) * 2008-05-21 2016-07-05 Theraject, Inc. Method of manufacturing solid solution perforator patches and uses thereof
CA2760680A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents
US9833183B2 (en) 2008-05-30 2017-12-05 Intuity Medical, Inc. Body fluid sampling device—sampling site interface
EP3984454A1 (en) 2008-06-06 2022-04-20 Intuity Medical, Inc. Medical diagnostic devices and methods
CA2726067C (en) 2008-06-06 2020-10-20 Intuity Medical, Inc. Detection meter and mode of operation
BRPI0920250A2 (en) 2008-10-15 2016-11-22 Smith & Nephew Inc composite internal fasteners
EP2358266A4 (en) 2008-11-20 2012-10-03 Bodymedia Inc Method and apparatus for determining critical care parameters
US20110293526A1 (en) * 2008-11-20 2011-12-01 University Of Southern California Compositions and methods to modulate hair growth
EP2375973A4 (en) 2008-12-16 2014-02-12 Bodymedia Inc Method and apparatus for determining heart rate variability using wavelet transformation
EP2387394B1 (en) 2009-01-14 2018-05-02 Corium International, Inc. Transdermal administration of tamsulosin
JP5620408B2 (en) 2009-01-27 2014-11-05 カリフォルニア インスティチュート オブテクノロジー Drug delivery and mass transfer facilitated by nano-reinforced devices with oriented carbon nanotubes protruding from the device surface
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
CN101856538B (en) * 2009-04-09 2012-06-20 香港理工大学 Microneedles array, die casting method for manufacturing microneedle array and die for manufacturing microneedle array
US9289925B2 (en) 2009-04-10 2016-03-22 3M Innovative Properties Company Methods of making hollow microneedle arrays and articles and uses therefrom
FI20095433A0 (en) * 2009-04-20 2009-04-20 Valtion Teknillinen micro-needle
BRPI1015460A2 (en) 2009-04-22 2020-08-18 Mercator Medsystems, Inc. guanetidine for use in the treatment of hypertension and hypertension treatment system
US20110006458A1 (en) * 2009-04-24 2011-01-13 Corium International, Inc. Methods for manufacturing microprojection arrays
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
EP2506768B1 (en) 2009-11-30 2016-07-06 Intuity Medical, Inc. Calibration material delivery devices and methods
GB2478363A (en) * 2010-03-05 2011-09-07 Ndm Technologies Ltd Microneedle patch and method of manufacture
US9115424B2 (en) 2010-04-07 2015-08-25 California Institute Of Technology Simple method for producing superhydrophobic carbon nanotube array
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
CA2797205C (en) 2010-04-28 2019-04-16 Kimberly-Clark Worldwide, Inc. Medical devices for delivery of sirna
CA2796965C (en) 2010-04-28 2019-04-16 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
RU2585159C2 (en) 2010-04-28 2016-05-27 Кимберли-Кларк Ворлдвайд, Инк. Device for delivering drug used in rheumatoid arthritis
WO2011135532A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. Composite microneedle array including nanostructures thereon
CA2798145C (en) 2010-05-04 2022-10-18 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
CN105662530B (en) 2010-05-04 2018-07-20 考里安国际公司 Micropin applicator
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
CN101905856B (en) * 2010-06-11 2012-10-10 北京大学 Method for preparing plane hollow microneedle for transdermal administration
CA2803797A1 (en) 2010-06-25 2011-12-29 Intuity Medical, Inc. Analyte monitoring methods and systems
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
JP5050130B2 (en) * 2010-10-25 2012-10-17 帝人化成株式会社 Micro needle
WO2012079066A2 (en) 2010-12-10 2012-06-14 California Institute Of Technology Method for producing graphene oxide with tunable gap
CN103619384A (en) * 2011-01-18 2014-03-05 麻省理工学院 Devices and uses thereof
US8976507B2 (en) 2011-03-29 2015-03-10 California Institute Of Technology Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles
GB201107642D0 (en) 2011-05-09 2011-06-22 Univ Cork Method
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
EP3750480B1 (en) 2011-08-03 2022-02-02 Intuity Medical, Inc. Body fluid sampling arrangement
EP2765927B1 (en) 2011-10-12 2021-02-24 Vaxxas Pty Limited Delivery device
CN103874518A (en) 2011-10-12 2014-06-18 3M创新有限公司 Integrated microneedle array delivery system
JP6069336B2 (en) 2011-10-19 2017-02-01 マーケイター メドシステムズ， インコーポレイテッド Local regulation of tissues and cells to enhance therapeutic effects including renal denervation
JP5879927B2 (en) * 2011-10-26 2016-03-08 凸版印刷株式会社 Microneedle device and manufacturing method thereof
AU2012328037B2 (en) 2011-10-27 2017-11-02 Sorrento Therapeutics, Inc. Transdermal delivery of high viscosity bioactive agents
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
JP2013111104A (en) * 2011-11-25 2013-06-10 Dainippon Printing Co Ltd Method for manufacturing microneedle device
WO2013090844A1 (en) 2011-12-14 2013-06-20 California Institute Of Technology Sharp tip carbon nanotube microneedle devices and their fabrication
WO2013090353A1 (en) 2011-12-16 2013-06-20 3M Innovative Properties Company Foldable adhesive composite dressing
EP2793869B1 (en) 2011-12-21 2015-09-23 3M Innovative Properties Company Transdermal adhesive patch assembly with removable microneedle array and method of using same
RU2627381C2 (en) 2012-01-16 2017-08-08 Конинклейке Филипс Н.В. Engineered surface for providing low friction and improved comfort on devices that contact the skin or other external tissue of the user
JP6106922B2 (en) * 2012-02-24 2017-04-05 凸版印刷株式会社 Manufacturing method of fine nozzle
CN103301092B (en) 2012-03-06 2014-12-03 中国科学院理化技术研究所 Polymer micro-needle array chip, and preparation method and application thereof
US9245671B2 (en) * 2012-03-14 2016-01-26 Ut-Battelle, Llc Electrically isolated, high melting point, metal wire arrays and method of making same
WO2013166162A1 (en) 2012-05-01 2013-11-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
WO2014004301A1 (en) * 2012-06-29 2014-01-03 Elc Management Llc Microneedles comprising one or more cosmetic ingredients
CN103568160B (en) * 2012-07-27 2015-11-04 中国科学院理化技术研究所 A kind of preparation method of polymer material micro-needle array patch
US9349543B2 (en) 2012-07-30 2016-05-24 California Institute Of Technology Nano tri-carbon composite systems and manufacture
US20200009364A1 (en) * 2012-09-13 2020-01-09 Avraham Amir Microneedles and compositions for skin augmentation
WO2014053081A1 (en) 2012-10-01 2014-04-10 The Hong Kong University Of Science And Technology Design and manufacture of nonelectronic, active-infusion patch and device for transdermal delivery across skin
EP2906285B1 (en) 2012-10-10 2019-06-12 3M Innovative Properties Company Applicator for applying a microneedle device to skin
EP2906284B8 (en) 2012-10-10 2021-01-20 Kindeva Drug Delivery L.P. Force-controlled applicator for applying a microneedle device to skin
EP2921203A4 (en) * 2012-11-13 2016-07-13 Fujifilm Corp Transdermal absorption sheet, and manufacturing method for same
EP2919849B1 (en) 2012-11-16 2021-01-06 Kindeva Drug Delivery L.P. Force-controlled applicator for applying a microneedle device to skin
WO2014076326A1 (en) * 2012-11-19 2014-05-22 Simplicity Works Europe, S.L. Tool for reproducing three-dimensional surfaces
WO2014100750A1 (en) 2012-12-21 2014-06-26 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
WO2014105458A1 (en) 2012-12-27 2014-07-03 3M Innovative Properties Company Article with hollow microneedles and method of making
CN104902943B (en) 2013-01-08 2017-10-31 3M创新有限公司 For the application device to dermal administration microneedle devices
US20150352777A1 (en) * 2013-01-18 2015-12-10 The University Of North Carolina At Chapel Hill High-throughput manufacturing of microneedles
EP2968887B1 (en) 2013-03-12 2022-05-04 Corium, Inc. Microprojection applicators
CN105228522B (en) 2013-03-14 2018-06-26 萨诺智能公司 For the microsensor on the human body of biological monitoring
US9192313B1 (en) 2013-03-14 2015-11-24 Orbital Research Inc. Dry physiological recording device and method of manufacturing
US10820860B2 (en) 2013-03-14 2020-11-03 One Drop Biosensor Technologies, Llc On-body microsensor for biomonitoring
AU2014237279B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
EP4194028A1 (en) 2013-03-15 2023-06-14 Corium Pharma Solutions, Inc. Multiple impact microprojection applicators
CN105188569B (en) 2013-03-15 2020-11-20 考里安公司 Microstructure array for delivery of active agents
WO2014151654A1 (en) 2013-03-15 2014-09-25 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
EP2968119B1 (en) 2013-03-15 2019-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP2016517707A (en) 2013-03-22 2016-06-20 スリーエム イノベイティブ プロパティズ カンパニー Microneedle applicator with counter assembly
DE102013005197A1 (en) 2013-03-25 2014-09-25 Michael Horstmann Swinging microneedle plaster
US10542922B2 (en) 2013-03-26 2020-01-28 The Trustees Of Columbia University In The City Of New York Fluid extraction and drug delivery system and methods using microneedles
ITTO20130284A1 (en) * 2013-04-09 2014-10-10 Fond Istituto Italiano Di Tecnologia PROCEDURE FOR THE PRODUCTION OF SHAPED POLYMERIC MICROPARTELS
JP6110562B2 (en) 2013-05-06 2017-04-05 ユービック インコーポレイテッド Method of manufacturing microstructure using centrifugal force and microstructure manufactured therefrom
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
KR102274902B1 (en) 2013-05-31 2021-07-07 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Microneedle injection and infusion apparatus and method of using same
WO2014193727A1 (en) 2013-05-31 2014-12-04 3M Innovative Properties Company Microneedle injection apparatus comprising a dual cover
KR101615592B1 (en) 2013-05-31 2016-04-26 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Microneedle injection apparatus comprising an inverted actuator
EP3007841A4 (en) * 2013-06-13 2017-02-22 Microdermics Inc. Metallic microneedles
CA2912283A1 (en) 2013-06-21 2014-12-21 Intuity Medical, Inc. Analyte monitoring system with audible feedback
WO2015009530A1 (en) 2013-07-16 2015-01-22 3M Innovative Properties Company Hollow microneedle array article
US10201691B2 (en) 2013-07-16 2019-02-12 3M Innovative Properties Article comprising a microneedle
EP3021930B1 (en) 2013-07-16 2020-10-07 3M Innovative Properties Company Hollow microneedle with beveled tip
US10384047B2 (en) 2013-07-16 2019-08-20 3M Innovative Properties Company Hollow microneedle with bevel opening
US20160193824A1 (en) * 2013-08-12 2016-07-07 Tufts University Micro forming devices and systems and uses thereof
WO2015038974A1 (en) 2013-09-13 2015-03-19 University Of Utah Research Foundation Micro-molded electrodes, arrays, and methods of making the same
US20180271800A1 (en) * 2017-03-24 2018-09-27 E Ink California, Llc Microcell systems for delivering active molecules
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US10321858B2 (en) 2014-08-18 2019-06-18 Proteadx, Inc. Apparatus and methods for transdermal sensing of analytes in interstitial fluid and associated data transmission systems
EP3193828B8 (en) 2014-08-29 2023-04-05 Corium Pharma Solutions, Inc. Microstructure array for delivery of active agents
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
JP6064012B1 (en) * 2014-10-17 2017-01-18 花王株式会社 Method for producing fine hollow projection
CN107073249B (en) * 2014-10-17 2021-01-01 花王株式会社 Method for producing fine hollow projections
WO2016065245A1 (en) 2014-10-24 2016-04-28 Incept, Llc Extra luminal scaffold
JP6906885B2 (en) 2014-11-14 2021-07-21 ロレアル Microneedle sheet to reduce wrinkles
WO2016118459A1 (en) 2015-01-21 2016-07-28 3M Innovative Properties Company Microneedle array and method of use
CN107206066A (en) 2015-01-27 2017-09-26 3M创新有限公司 Aluminated coating agent for micropin vaccine patch
CA3204959A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
WO2016132996A1 (en) * 2015-02-16 2016-08-25 凸版印刷株式会社 Microneedle
EP3265064A4 (en) * 2015-03-04 2018-11-07 Microvention, Inc. Drug delivery device
BR112017019272A2 (en) 2015-03-10 2018-05-02 Allergan Pharmaceuticals Holdings Ireland Unlimited Company multiple needle injector
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP6646985B2 (en) * 2015-09-08 2020-02-14 花王株式会社 Manufacturing method of fine projection tool
TWI647171B (en) * 2015-09-08 2019-01-11 國立臺灣科技大學 Method for fabricating a micro-needle array
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
JP2017131397A (en) * 2016-01-27 2017-08-03 花王株式会社 Method of producing fine, and hollow projection tool
US10939912B2 (en) 2016-03-01 2021-03-09 Kitotech Medical, Inc. Microstructure-based systems, apparatus, and methods for wound closure
JP6717638B2 (en) * 2016-03-31 2020-07-01 花王株式会社 Method for manufacturing fine hollow protrusion having opening
JP6693790B2 (en) * 2016-03-31 2020-05-13 花王株式会社 Method for manufacturing fine hollow protrusion having opening
CN105771082A (en) * 2016-04-07 2016-07-20 南通纺织丝绸产业技术研究院 Blank pipe fibroin microneedle drug administration system and preparation method thereof
RU2725968C2 (en) 2016-04-08 2020-07-07 Аллерган, Инк. Aspiration-injection device
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
KR102038751B1 (en) * 2016-11-18 2019-10-30 연세대학교 산학협력단 Microneddle array with complex formulation and method for manufacturing the same
US11235132B2 (en) * 2016-12-22 2022-02-01 Ohio State Innovation Foundation Interpenetrating microstructures for nanochannel-based cargo delivery
EP3372165A1 (en) * 2017-03-07 2018-09-12 Koninklijke Philips N.V. Enhanced sampling using applied energy
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
WO2018176102A1 (en) 2017-03-31 2018-10-04 Vaxxas Pty Limited Device and method for coating surfaces
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
TWI633901B (en) * 2017-05-16 2018-09-01 怡定興科技股份有限公司 Medical beauty microneedle patch manufacturing method
TWI629073B (en) * 2017-05-16 2018-07-11 怡定興科技股份有限公司 Microneedle patch manufacturing method
US11690990B2 (en) 2017-06-07 2023-07-04 Kao Corporation Method for manufacturing microprojection unit
CA3065371A1 (en) 2017-06-13 2018-12-20 Vaxxas Pty Limited Quality control of substrate coatings
EP4218893A1 (en) 2017-08-04 2023-08-02 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
JP6965068B2 (en) * 2017-09-13 2021-11-10 花王株式会社 Hollow protrusion manufacturing method, hollow protrusion manufacturing equipment, and hollow protrusion
WO2019058329A1 (en) 2017-09-22 2019-03-28 Sabic Global Technologies B.V. Methods and systems of producing microneedle arrays
WO2019058328A1 (en) 2017-09-22 2019-03-28 Sabic Global Technologies B.V. Microneedle arrays
WO2019077519A1 (en) 2017-10-17 2019-04-25 3M Innovative Properties Company Applicator for applying a microneedle array to skin
JP2021526431A (en) 2018-05-16 2021-10-07 キンデーバ ドラッグ デリバリー リミティド パートナーシップ Microneedle biosensor
USD875254S1 (en) 2018-06-08 2020-02-11 Biolinq, Inc. Intradermal biosensor
US20210276228A1 (en) 2018-06-25 2021-09-09 Corium, Inc. Hybrid method of forming microstructure array molds, methods of making microstructure arrays, and methods of use
CN109173039B (en) * 2018-08-17 2021-03-16 安徽中鼎玉铉新材料科技有限公司 Preparation method of inverted funnel-shaped silicon-based solid microneedle array
WO2020045933A1 (en) * 2018-08-28 2020-03-05 연세대학교 산학협력단 Perforated plate microstructure module
US10940554B2 (en) 2018-11-30 2021-03-09 International Business Machines Corporation Planar fabrication of micro-needles
CN111298279B (en) * 2018-12-11 2024-01-26 尹忠 Preparation device and preparation method of drug administration microneedle
US11478194B2 (en) 2020-07-29 2022-10-25 Biolinq Incorporated Continuous analyte monitoring system with microneedle array
CN112807561A (en) * 2021-01-26 2021-05-18 上海烨映微电子科技股份有限公司 Microneedle structure and method for producing same
USD988160S1 (en) 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
CN116113454A (en) 2021-05-08 2023-05-12 比奥林股份有限公司 Continuous analyte monitoring device fault detection based on microneedle arrays
WO2023283385A1 (en) 2021-07-07 2023-01-12 The Regents Of The University Of California Wearable, non-intrusive microneedle sensor
CN113977829A (en) * 2021-09-08 2022-01-28 北京宝理泰科技有限公司 Preparation method of hollow microneedle array biosensor
USD996999S1 (en) 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
USD1013544S1 (en) 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
US11957346B2 (en) 2022-02-18 2024-04-16 Kitotech Medical, Inc. Force modulating deep skin staples and instruments
CN114935595B (en) * 2022-04-15 2024-02-06 北京大学 Manufacturing method of microneedle biosensor
USD1012744S1 (en) 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display
CN115956929B (en) * 2023-01-09 2023-07-25 华中科技大学 Multi-brain-area electrode array combining recording and optical stimulation and preparation method thereof

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3704194A (en) * 1970-07-02 1972-11-28 Gen Electric Perforated reinforced plastic member and method for making
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4180232A (en) * 1977-01-13 1979-12-25 Hardigg James S Truss panel mold
JPS5428369A (en) * 1977-08-03 1979-03-02 Yamakawa Tsuneko Method of forming needleelike projection of thermoplastic resin on sheet
US4381963A (en) 1980-07-30 1983-05-03 The University Of Rochester Micro fabrication molding process
US4585991A (en) * 1982-06-03 1986-04-29 Texas Instruments Incorporated Solid state multiprobe testing apparatus
US5135477A (en) 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
US4784737A (en) 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US4837049A (en) 1986-06-17 1989-06-06 Alfred E. Mann Foundation For Scientific Research Method of making an electrode array
DE3880763T2 (en) * 1987-08-24 1993-12-02 Procter & Gamble Substantially liquid-impermeable polymeric web of material with microbubbles and method and device for their production.
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
SU1667864A1 (en) 1989-03-23 1991-08-07 Опытный завод энергетического машиностроения Electrostimulation device
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
TW279133B (en) 1990-12-13 1996-06-21 Elan Med Tech
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
US5252279A (en) * 1991-01-17 1993-10-12 Reinhold Industries Method for making perforated articles
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5256360A (en) 1992-03-25 1993-10-26 Panasonic Technologies, Inc. Method of manufacturing a precision micro-filter
IE930532A1 (en) 1993-07-19 1995-01-25 Elan Med Tech Liquid material dispenser and valve
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5383512A (en) 1993-01-27 1995-01-24 Midwest Research Institute Method for fabricating a substrate having spaced apart microcapillaries thereon
CA2132277C (en) 1993-10-22 2005-05-10 Giorgio Cirelli Injection device
US5457041A (en) * 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
CA2149943C (en) 1994-05-23 1999-07-13 Kwang Kyun Jang Skin perforating device for transdermal medication
KR0134151B1 (en) 1994-05-23 1998-04-14 이형도 Insulin patch
US5591139A (en) 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5771890A (en) 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US5498235A (en) 1994-09-30 1996-03-12 Becton Dickinson And Company Iontophoresis assembly including patch/controller attachment
US5551953A (en) 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (en) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneal drug delivery system
JP2713255B2 (en) 1995-08-11 1998-02-16 日本電気株式会社 Leachate suction device
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
US5735273A (en) 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
US5645977A (en) * 1995-09-22 1997-07-08 Industrial Technology Research Institute Method of making molds for manufacturing multiple-lead microstructures
US5658515A (en) 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
AU3399197A (en) 1996-06-18 1998-01-07 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US6183434B1 (en) 1996-07-03 2001-02-06 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
US5928207A (en) 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
AU739616B2 (en) 1997-12-11 2001-10-18 Alza Corporation Device for enhancing transdermal agent flux
CN1206004C (en) 1997-12-11 2005-06-15 阿尔扎有限公司 Device for enhancing transdermal agent flux
WO1999029365A1 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
JP2002517300A (en) 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション Microneedle devices and methods of manufacture and uses thereof
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array

Also Published As

Publication number Publication date
JP2003501161A (en) 2003-01-14
JP4436992B2 (en) 2010-03-24
CA2376283A1 (en) 2000-12-14
CA2689890C (en) 2012-09-04
TW512067B (en) 2002-12-01
EP1183064B1 (en) 2012-12-19
AU5727900A (en) 2000-12-28
US6471903B2 (en) 2002-10-29
US20020020688A1 (en) 2002-02-21
US6451240B1 (en) 2002-09-17
CA2376283C (en) 2007-08-28
US6312612B1 (en) 2001-11-06
EP1183064A1 (en) 2002-03-06
WO2000074764A1 (en) 2000-12-14

Similar Documents

Publication Publication Date Title
CA2689890A1 (en) Method of manufacturing an intracutaneous microneedle array
KR100682534B1 (en) Method for manufacturing microneedle array
TW408231B (en) Erecting life-size resin lens array and the manufacturing method thereof
JP2003094445A (en) Manufacturing method for fine structure, manufacturing method for device equipped with the fine structure, fine structure by the manufacturing method, device for manufacturing the fine structure, and device for manufacturing device equipped with the fine structure
JP2001201609A (en) Method for producing planer microlens and planar microlens produced by the method
CN100441388C (en) Microneedle preparation method based on multiplayer processing technology
JP2002086462A (en) Method and device for producing substrate
JP2002321227A (en) Method for manufacturing matrix for molding optical element, method for manufacturing optical element using matrix and optical element by the manufacturing method
KR100537722B1 (en) Method and device for ultraviolet continuous curing method for fabrication of micro patterns using drum-type stamper
US20060110845A1 (en) Method of manufacturing micro-structure element by utilizing molding glass
JP2009208171A (en) L-shaped microneedle device and its manufacturing method
CA2591168A1 (en) Method of manufacturing an intracutaneous microneedle array
JP2002321227A5 (en) Method of manufacturing optical element molding master, and method of manufacturing optical element using the mother die
KR100614039B1 (en) Embossing belt manufacturing method for self-reflective plastic sheet
JP2981256B2 (en) Manufacturing method of optical parts
JP2003080537A (en) Mold for molding plastics and molding method
CN101570045B (en) Manufacturing method for insert
JP2003011131A (en) Mold manufacturing method and method for manufacturing optical element
TWI420261B (en) Method for manufacturing mold core
JP2004025647A (en) Insert, mold, and manufacturing method for them
KR101408737B1 (en) Mold in which Micro pattern and Nano hologram pattern are molded and Method for Manufacturing same
JP2002210745A (en) Method for manufacturing mold and replica master as well as mold
CN113727530B (en) Preparation process of electronic device based on shape memory polymer
KR101682556B1 (en) Method for Manufacturing Micro-scale Surface Wrinkles On Metal Structures
JP2004017477A5 (en)

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20190607